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644 results on '"Stowe, Zachary"'

52. Continuous Fetal Monitoring During Electroconvulsive Therapy: A Prospective Observation Study

Author

Rabie,Nader, Shah,Ronak, Ray-Griffith,Shona, Coker,Jessica L, Magann,Everett F, Stowe,Zachary N, Rabie,Nader, Shah,Ronak, Ray-Griffith,Shona, Coker,Jessica L, Magann,Everett F, and Stowe,Zachary N

Abstract

Nader Rabie,1 Ronak Shah,2 Shona Ray-Griffith,3 Jessica L Coker,3 Everett F Magann,4 Zachary N Stowe5 1Tripler Army Medical Center, Department of Obstetrics and Gynecology, Honolulu, HI, USA; 2Our Lady of Angels, Department of Obstetrics and Gynecology, Bogalusa, LA, USA; 3University of Arkansas for Medical Sciences, Department of Psychiatry, Little Rock, AR, USA; 4University of Arkansas for Medical Sciences, Department of Obstetrics and Gynecology, Little Rock, AR, USA; 5University of Wisconsin School of Medicine and Public Health, Psychiatric Institute and Clinic, Madison, WI, USACorrespondence: Everett F MagannUniversity of Arkansas for Medical Sciences, Department of Obstetrics and Gynecology, Little Rock, AR, USAEmail efmagann@uams.eduObjective: The use of electroconvulsive therapy in pregnancy has been limited by concerns about its effects on fetal well-being, despite limited evidence that suggests it is safe and effective. No studies have utilized continuous fetal heart rate monitoring during electroconvulsive therapy sessions. We aimed to describe the fetal heart rate patterns of patients undergoing electroconvulsive therapy.Design: This study is a prospective case series of pregnant patients undergoing electroconvulsive therapy with continuous fetal heart rate monitoring.Setting: University-based hospital.Population: Pregnant patients with a psychiatric indication for electroconvulsive therapy.Methods: Patients underwent fetal heart rate monitoring immediately prior, during and immediately after ECT therapy.Main Outcome Measures: Characterization of the fetal heart rate tracing.Results: Five subjects underwent 44 electroconvulsive therapy sessions. Continuous fetal monitoring was performed on 34 of the sessions. Transient fetal heart rate decelerations occurred in 4 sessions, all self-resolved and none required intervention.Conclusion: This case series is the first to report the results of continuous FHR monitoring during electroconvulsive therapy. The most

Published
2021

59. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene

Author

Bradley, Rebekah G., Binder, Elisabeth B., Epstein, Michael P., Tan, Yilang, Nair, Hemu P., Liu, Wei, Gillespie, Charles F., Berg, Tiina, Evces, Mark, Newport, D. Jeffrey, Stowe, Zachary N., Heim, Christine M., Schwartz, Ann, Cubells, Joseph F., and Ressler, Kerry J.

Subjects
Child abuse -- Influence, Depression, Mental -- Risk factors, Depression, Mental -- Genetic aspects, Life change events -- Influence, Corticotropin releasing hormone -- Genetic aspects, Corticotropin releasing hormone -- Research, Health, Psychology and mental health
Published
2008

60. Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities

Author

DeVane, C. Lindsay, Stowe, Zachary N., Donovan, Jennifer L., Newport, D. Jeffrey, Pennell, Page B., Ritchie, James C., Owens, Michael J., and Wang, Jun-Sheng

Subjects
Pregnancy -- Research -- Psychological aspects, Mental illness -- Research, Pharmaceuticals and cosmetics industries, Psychology and mental health, Psychological aspects, Research
Abstract

Abstract Various symptoms of mental illness occur commonly during pregnancy. It is estimated that serious mental disorders, including major depression, bipolar disorder, schizophrenia, panic and other anxiety disorders, occur with [...]

Published
2006

61. Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment

Author

Cohen, Lee S., Altshuler, Lori L., Stowe, Zachary N., Harlow, Bernard L., Nonacs, Ruta, Jeffrey Newport, D., Viguera, Adele C., Suri, Rita, Burt, Vivien K., Hendrick, Victoria, Reminick, Alison M., Loughead, Ada, and Vitonis, Allison F.

Subjects
Depression, Mental -- Risk factors, Depression, Mental -- Drug therapy, Pregnant women -- Psychological aspects, Antidepressants -- Usage
Abstract

The study is carried out to describe risk of relapse in pregnant women who discontinued antidepressant medication proximate to conception compared to those who maintained treatment with these medications. It is observed that women who discontinued medication relapsed significantly more frequently over the course of their pregnancy compared with women who maintained their medication.

Published
2006

95. Paroxetine in Breast Milk

Author

STOWE, ZACHARY N., COHEN, LEE S., RITCHIE, JAMES C., OWENS, MICHAEL J., and NEMEROFF, CHARLES B.

Published
2001

98. Consistency of EEG asymmetry patterns in infants of depressed mothers.

Author

Goodman, Sherryl H., Liu, Ran, Lusby, Cara M., Park, Ji Soo, Bell, Martha Ann, Newport, D. Jeffrey, and Stowe, Zachary N.

Abstract

We evaluated frontal electroencephalogram (EEG) asymmetry across multiple contexts as an index of a general affective response predisposition in 12‐month‐old infants whose mothers were at elevated risk for perinatal depression due to their mother's history of depression. We further examined mothers' prenatal, postnatal, and concurrent depressive symptom levels in relation to infants' frontal EEG asymmetry consistency. Mothers (n = 132) with a history of depression prior to pregnancy completed depressive symptom scales repeatedly during pregnancy and the first year postpartum. Their 12‐month‐old infants' frontal EEG asymmetry was recorded across five contexts (baseline/bubbles, peek‐a‐boo, play, feeding, and distract). Frontal EEG asymmetries showed small to moderate correlations across contexts. Mothers' prenatal depression symptom levels (not postnatal or concurrent) were associated with infants having consistent right, rather than left, frontal EEG asymmetry, even after controlling for infants' observed affect. These findings demonstrate the consistency of EEG asymmetry scores across contexts in 12‐month‐old infants at risk for the development of psychopathology, providing support for relative right frontal EEG asymmetry as a trait marker of vulnerability to depression. Findings also suggest the importance of mothers' prenatal, rather than postnatal or concurrent depression, in predicting infants' consistent patterns of relative right frontal EEG asymmetry across contexts. [ABSTRACT FROM AUTHOR]

Published
2021
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100. Fetal Assessment in Buprenorphine Maintained Women using Fetal Magnetoencephalography: A Pilot Study

Author

ESCALONA-VARGAS, Diana, COKER, Jessica L., RAY-GRIFFITH, Shona, SIEGEL, Eric R., LOWERY, Curtis L., STOWE, Zachary N., and ESWARAN, Hari

Subjects
Adult, Magnetocardiography, Brain, Magnetoencephalography, Pilot Projects, Heart Rate, Fetal, Opioid-Related Disorders, Article, Buprenorphine, Analgesics, Opioid, Pregnancy Complications, Young Adult, Fetus, Pregnancy, Case-Control Studies, Humans, Female, Fetal Monitoring, Fetal Movement
Abstract

BACKGROUND AND AIMS: In-utero exposure to opioids including buprenorphine (BUP) has been shown to affect fetal activity, specifically heart-rate variability (FHRV) and fetal movement (FM). Our objective was to extract simultaneous recordings of fetal cardiac, and brain-related activity in BUP-maintained and non-opioid exposed pregnant women using a novel non-invasive biomagnetic technique. DESIGN: A pilot study was conducted, recording and analyzing biomagnetic data from fetuses of BUP-maintained and non-opioid exposed pregnant women. Signals were acquired with non-invasive 151-channel SARA (SQUID-Array for Reproductive Assessment) system. Advanced signal-processing techniques were applied to extract fetal heart and brain activity. SETTING: University of Arkansas for Medical Sciences (UAMS, Little Rock, Arkansas, USA). PARTICIPANTS: Eight BUP-maintained pregnant women from UAMS Women’s Mental Health Program between gestational ages (GA) of 29 to 37 weeks who were treated with 8mg to 24mg of BUP daily. Sixteen pregnant women with no known opioid-exposure in the same GA range were also included. MEASUREMENTS: Outcome measures from the fetal heart and brain signals included: heart rate (FHR), FM, FHR accelerations, FHR-FM coupling, FHRV, fetal behavioral states (FBS) and power spectral density (PSD) of spontaneous brain activity. These measures were analyzed at three GA intervals. FINDINGS: Fetal heart and brain activity parameters were successfully extracted and quantified from 18 non-opioid and 16 BUP recordings. Overall analysis in both groups show that: FHR and FM ranged from 131-141 bpm and 5-11 counts, respectively. In the 35-37 week GA, the coupling duration (~9s) was the shortest, while three of the FHRV parameters were the highest. The PSD of brain activity revealed highest power in 0.5-4Hz bandwidth. Transitions in FBS from quiet to active sleep were >50% of sessions. CONCLUSIONS: This pilot study showed that a novel biomagnetic technique allows simultaneous quantification of cardiac and brain activities of a group of buprenorphine-exposed and non-exposed fetuses in the third trimester.

Published
2018

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