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51. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

Author

Sahm, Felix, Schrimpf, Daniel, Stichel, Damian, Jones, David T W, Hielscher, Thomas, Schefzyk, Sebastian, Okonechnikov, Konstantin, Koelsche, Christian, Reuss, David E, Capper, David, Sturm, Dominik, Wirsching, Hans-Georg, Berghoff, Anna Sophie, Baumgarten, Peter, Kratz, Annekathrin, Huang, Kristin, Wefers, Annika K, Hovestadt, Volker, Sill, Martin, Ellis, Hayley P, Kurian, Kathreena M, Okuducu, Ali Fuat, Jungk, Christine, Drueschler, Katharina, Schick, Matthias, Bewerunge-Hudler, Melanie, Mawrin, Christian, Seiz-Rosenhagen, Marcel, Ketter, Ralf, Simon, Matthias, Westphal, Manfred, Lamszus, Katrin, Becker, Albert, Koch, Arend, Schittenhelm, Jens, Rushing, Elisabeth J, Collins, V Peter, Brehmer, Stefanie, Chavez, Lukas, Platten, Michael, Hänggi, Daniel, Unterberg, Andreas, Paulus, Werner, Wick, Wolfgang, Pfister, Stefan M, Mittelbronn, Michel, Preusser, Matthias, Herold-Mende, Christel, Weller, Michael, and von Deimling, Andreas

Published
2017
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52. The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

Author

Ballhausen, Alexej, Przybilla, Moritz Jakob, Jendrusch, Michael, Haupt, Saskia, Pfaffendorf, Elisabeth, Seidler, Florian, Witt, Johannes, Hernandez Sanchez, Alejandro, Urban, Katharina, Draxlbauer, Markus, Krausert, Sonja, Ahadova, Aysel, Kalteis, Martin Simon, Pfuderer, Pauline L., Heid, Daniel, Stichel, Damian, Gebert, Johannes, Bonsack, Maria, Schott, Sarah, Bläker, Hendrik, Seppälä, Toni, Mecklin, Jukka-Pekka, Ten Broeke, Sanne, Nielsen, Maartje, Heuveline, Vincent, Krzykalla, Julia, Benner, Axel, Riemer, Angelika Beate, von Knebel Doeberitz, Magnus, and Kloor, Matthias

Published
2020
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54. Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Author

Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., and von Deimling, Andreas

Published
2018
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55. DNA methylation-based reclassification of olfactory neuroblastoma

Author

Capper, David, Engel, Nils W., Stichel, Damian, Lechner, Matt, Glöss, Stefanie, Schmid, Simone, Koelsche, Christian, Schrimpf, Daniel, Niesen, Judith, Wefers, Annika K., Jones, David T. W., Sill, Martin, Weigert, Oliver, Ligon, Keith L., Olar, Adriana, Koch, Arend, Forster, Martin, Moran, Sebastian, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, Esteller, Manel, Alonso, Javier, del Muro, Xavier Garcia, Paulus, Werner, Felsberg, Jörg, Reifenberger, Guido, Glatzel, Markus, Frank, Stephan, Monoranu, Camelia M., Lund, Valerie J., von Deimling, Andreas, Pfister, Stefan, Buslei, Rolf, Ribbat-Idel, Julika, Perner, Sven, Gudziol, Volker, Meinhardt, Matthias, and Schüller, Ulrich

Published
2018
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56. Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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57. Data from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Author

González-Vallinas, Margarita, primary, Rodríguez-Paredes, Manuel, primary, Albrecht, Marco, primary, Sticht, Carsten, primary, Stichel, Damian, primary, Gutekunst, Julian, primary, Pitea, Adriana, primary, Sass, Steffen, primary, Sánchez-Rivera, Francisco J., primary, Lorenzo-Bermejo, Justo, primary, Schmitt, Jennifer, primary, De La Torre, Carolina, primary, Warth, Arne, primary, Theis, Fabian J., primary, Müller, Nikola S., primary, Gretz, Norbert, primary, Muley, Thomas, primary, Meister, Michael, primary, Tschaharganeh, Darjus F., primary, Schirmacher, Peter, primary, Matthäus, Franziska, primary, and Breuhahn, Kai, primary

Published
2023
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58. Supplementary Table S4 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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59. Supplementary Figures S1-S8 from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Author

González-Vallinas, Margarita, primary, Rodríguez-Paredes, Manuel, primary, Albrecht, Marco, primary, Sticht, Carsten, primary, Stichel, Damian, primary, Gutekunst, Julian, primary, Pitea, Adriana, primary, Sass, Steffen, primary, Sánchez-Rivera, Francisco J., primary, Lorenzo-Bermejo, Justo, primary, Schmitt, Jennifer, primary, De La Torre, Carolina, primary, Warth, Arne, primary, Theis, Fabian J., primary, Müller, Nikola S., primary, Gretz, Norbert, primary, Muley, Thomas, primary, Meister, Michael, primary, Tschaharganeh, Darjus F., primary, Schirmacher, Peter, primary, Matthäus, Franziska, primary, and Breuhahn, Kai, primary

Published
2023
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60. Supplementary Data - Tables from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Author

González-Vallinas, Margarita, primary, Rodríguez-Paredes, Manuel, primary, Albrecht, Marco, primary, Sticht, Carsten, primary, Stichel, Damian, primary, Gutekunst, Julian, primary, Pitea, Adriana, primary, Sass, Steffen, primary, Sánchez-Rivera, Francisco J., primary, Lorenzo-Bermejo, Justo, primary, Schmitt, Jennifer, primary, De La Torre, Carolina, primary, Warth, Arne, primary, Theis, Fabian J., primary, Müller, Nikola S., primary, Gretz, Norbert, primary, Muley, Thomas, primary, Meister, Michael, primary, Tschaharganeh, Darjus F., primary, Schirmacher, Peter, primary, Matthäus, Franziska, primary, and Breuhahn, Kai, primary

Published
2023
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61. Suppl. Figure Legends from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Author

González-Vallinas, Margarita, primary, Rodríguez-Paredes, Manuel, primary, Albrecht, Marco, primary, Sticht, Carsten, primary, Stichel, Damian, primary, Gutekunst, Julian, primary, Pitea, Adriana, primary, Sass, Steffen, primary, Sánchez-Rivera, Francisco J., primary, Lorenzo-Bermejo, Justo, primary, Schmitt, Jennifer, primary, De La Torre, Carolina, primary, Warth, Arne, primary, Theis, Fabian J., primary, Müller, Nikola S., primary, Gretz, Norbert, primary, Muley, Thomas, primary, Meister, Michael, primary, Tschaharganeh, Darjus F., primary, Schirmacher, Peter, primary, Matthäus, Franziska, primary, and Breuhahn, Kai, primary

Published
2023
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62. Supplementary Data - Materials and Methods from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients

Author

González-Vallinas, Margarita, primary, Rodríguez-Paredes, Manuel, primary, Albrecht, Marco, primary, Sticht, Carsten, primary, Stichel, Damian, primary, Gutekunst, Julian, primary, Pitea, Adriana, primary, Sass, Steffen, primary, Sánchez-Rivera, Francisco J., primary, Lorenzo-Bermejo, Justo, primary, Schmitt, Jennifer, primary, De La Torre, Carolina, primary, Warth, Arne, primary, Theis, Fabian J., primary, Müller, Nikola S., primary, Gretz, Norbert, primary, Muley, Thomas, primary, Meister, Michael, primary, Tschaharganeh, Darjus F., primary, Schirmacher, Peter, primary, Matthäus, Franziska, primary, and Breuhahn, Kai, primary

Published
2023
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63. Supplementary Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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64. Table S6 from Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study

Author

Delaidelli, Alberto, primary, Dunham, Christopher, primary, Santi, Mariarita, primary, Negri, Gian Luca, primary, Triscott, Joanna, primary, Zheludkova, Olga, primary, Golanov, Andrey, primary, Ryzhova, Marina, primary, Okonechnikov, Konstantin, primary, Schrimpf, Daniel, primary, Stichel, Damian, primary, Ellison, David W., primary, von Deimling, Andreas, primary, Kool, Marcel, primary, Pfister, Stefan M., primary, Ramaswamy, Vijay, primary, Korshunov, Andrey, primary, Taylor, Michael D., primary, and Sorensen, Poul H., primary

Published
2023
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65. Figure S7 from Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study

Author

Delaidelli, Alberto, primary, Dunham, Christopher, primary, Santi, Mariarita, primary, Negri, Gian Luca, primary, Triscott, Joanna, primary, Zheludkova, Olga, primary, Golanov, Andrey, primary, Ryzhova, Marina, primary, Okonechnikov, Konstantin, primary, Schrimpf, Daniel, primary, Stichel, Damian, primary, Ellison, David W., primary, von Deimling, Andreas, primary, Kool, Marcel, primary, Pfister, Stefan M., primary, Ramaswamy, Vijay, primary, Korshunov, Andrey, primary, Taylor, Michael D., primary, and Sorensen, Poul H., primary

Published
2023
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66. Supplementary Legend from Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study

Author

Delaidelli, Alberto, primary, Dunham, Christopher, primary, Santi, Mariarita, primary, Negri, Gian Luca, primary, Triscott, Joanna, primary, Zheludkova, Olga, primary, Golanov, Andrey, primary, Ryzhova, Marina, primary, Okonechnikov, Konstantin, primary, Schrimpf, Daniel, primary, Stichel, Damian, primary, Ellison, David W., primary, von Deimling, Andreas, primary, Kool, Marcel, primary, Pfister, Stefan M., primary, Ramaswamy, Vijay, primary, Korshunov, Andrey, primary, Taylor, Michael D., primary, and Sorensen, Poul H., primary

Published
2023
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67. Clinical implementation of integrated molecular-morphologic risk prediction for meningioma

Author

Hielscher, Thomas, Sill, Martin, Sievers, Philipp, Stichel, Damian, Brandner, Sebastian, Jones, David T.W., von Deimling, Andreas, Sahm, Felix, Maas, Sybren L.N., Hielscher, Thomas, Sill, Martin, Sievers, Philipp, Stichel, Damian, Brandner, Sebastian, Jones, David T.W., von Deimling, Andreas, Sahm, Felix, and Maas, Sybren L.N.

Abstract

Risk prediction for meningioma tumors was until recently almost exclusively based on morphological features of the tumor. To improve risk prediction, multiple models have been established that incorporate morphological and molecular features for an integrated risk prediction score. One such model is the integrated molecular-morphologic meningioma integrated score (IntS), which allocates points to the histological grade, epigenetic methylation family and specific copy-number variations. After publication of the IntS, questions arose in the neuropathological community about the practical and clinical implementation of the IntS, specifically regarding the calling of CNVs, the applicability of the newly available version (v12.5) of the brain tumor classifier and the need for incorporation of TERT-promoter and CDKN2A/B status analysis in the IntS calculation. To investigate and validate these questions additional analyses of the discovery (n = 514), retrospective validation (n = 184) and prospective validation (n = 287) cohorts used for IntS discovery and validation were performed. Our findings suggest that any loss over 5% of the chromosomal arm suffices for the calling of a CNV, that input from the v12.5 classifier is as good or better than the dedicated meningioma classifier (v2.4) and that there is most likely no need for additional testing for TERT-promoter mutations and/or homozygous losses of CDKN2A/B when defining the IntS for an individual patient. The findings from this study help facilitate the clinical implementation of IntS-based risk prediction for meningioma patients.

Published
2023

68. Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification (Acta Neuropathologica, (2023), 145, 1, (49-69), 10.1007/s00401-022-02516-2)

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K, Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G, Hayden, James T, Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte E G, Tops, Bastiaan B J, Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M, Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J, Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M, Sahm, Felix, and Solomon, David A

Subjects
Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc
Abstract

In the original publication, incorrect version of Fig. 6 was published and the correct version (Fig. 6) is given below. The original article has been corrected.

Published
2023

69. Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Author

Reinhardt, Annekathrin, Stichel, Damian, Schrimpf, Daniel, Koelsche, Christian, Wefers, Annika K., Ebrahimi, Azadeh, Sievers, Philipp, Huang, Kristin, Casalini, M. Belén, Fernández-Klett, Francisco, Suwala, Abigail, Weller, Michael, Gramatzki, Dorothee, Felsberg, Joerg, Reifenberger, Guido, Becker, Albert, Hans, Volkmar H., Prinz, Marco, Staszewski, Ori, Acker, Till, Dohmen, Hildegard, Hartmann, Christian, Paulus, Werner, Heß, Katharina, Brokinkel, Benjamin, Schittenhelm, Jens, Buslei, Rolf, Deckert, Martina, Mawrin, Christian, Hewer, Ekkehard, Pohl, Ute, Jaunmuktane, Zane, Brandner, Sebastian, Unterberg, Andreas, Hänggi, Daniel, Platten, Michael, Pfister, Stefan M., Wick, Wolfgang, Herold-Mende, Christel, Korshunov, Andrey, Reuss, David E., Sahm, Felix, Jones, David T. W., Capper, David, and von Deimling, Andreas

Published
2019
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70. Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype

Author

Koelsche, Christian, Stichel, Damian, Griewank, Klaus G., Schrimpf, Daniel, Reuss, David E., Bewerunge-Hudler, Melanie, Vokuhl, Christian, Dinjens, Winand N. M., Petersen, Iver, Mittelbronn, Michel, Cuevas-Bourdier, Adrian, Buslei, Rolf, Pfister, Stefan M., Flucke, Uta, Mechtersheimer, Gunhild, Mentzel, Thomas, and von Deimling, Andreas

Published
2019
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71. Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, primary, Sill, Martin, additional, Wittmann, Andrea, additional, Joshi, Piyush, additional, Stichel, Damian, additional, Beck, Pengbo, additional, Okonechnikow, Konstantin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Roncaroli, Federico, additional, Avula, Shivaram, additional, McCabe, Martin G., additional, Hayden, James T., additional, Wesseling, Pieter, additional, Øra, Ingrid, additional, Nistér, Monica, additional, Kranendonk, Mariëtte E. G., additional, Tops, Bastiaan B. J., additional, Zapotocky, Michal, additional, Zamecnik, Josef, additional, Vasiljevic, Alexandre, additional, Fenouil, Tanguy, additional, Meyronet, David, additional, von Hoff, Katja, additional, Schüller, Ulrich, additional, Loiseau, Hugues, additional, Figarella-Branger, Dominique, additional, Kramm, Christof M., additional, Sturm, Dominik, additional, Scheie, David, additional, Rauramaa, Tuomas, additional, Pesola, Jouni, additional, Gojo, Johannes, additional, Haberler, Christine, additional, Brandner, Sebastian, additional, Jacques, Tom, additional, Sexton Oates, Alexandra, additional, Saffery, Richard, additional, Koscielniak, Ewa, additional, Baker, Suzanne J., additional, Yip, Stephen, additional, Snuderl, Matija, additional, Ud Din, Nasir, additional, Samuel, David, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Selt, Florian, additional, Ecker, Jonas, additional, Milde, Till, additional, von Deimling, Andreas, additional, Korshunov, Andrey, additional, Perry, Arie, additional, Pfister, Stefan M., additional, Sahm, Felix, additional, Solomon, David A., additional, and Jones, David T. W., additional

Published
2022
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73. PATH-46. COMPUTATIONAL HISTOPATHOLOGY INFORMED RAPID TARGETED NANOPORE SEQUENCING ENABLES AFFORDABLE NEXT DAY REPORTING OF COMPREHENSIVE MOLECULAR MARKERS FOR CNS TUMOUR DIAGNOSTICS

Author

Patel, Areeba, primary, Dogan, Helin, additional, Jung, Alexander, additional, Seferbekova, Zaira, additional, Payne, Alexander, additional, Ritter, Michael, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Hamelmann, Stefan, additional, Blume, Christina, additional, Euskirchen, Philipp, additional, Goidts, Violaine, additional, Sill, Martin, additional, Pfister, Stefan, additional, Loose, Matthew, additional, Wick, Wolfgang, additional, von Deimling, Andreas, additional, Jones, David T, additional, Schlesner, Matthias, additional, Gerstung, Moritz, additional, and Sahm, Felix, additional

Published
2022
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74. Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

Author

Sahm, Felix, Toprak, Umut H., Hübschmann, Daniel, Kleinheinz, Kortine, Buchhalter, Ivo, Sill, Martin, Stichel, Damian, Schick, Matthias, Bewerunge-Hudler, Melanie, Schrimpf, Daniel, Zadeh, Gelareh, Aldape, Ken, Herold-Mende, Christel, Beck, Katja, Staszewski, Ori, Prinz, Marco, Harosh, Carmit Ben, Eils, Roland, Sturm, Dominik, Jones, David T. W., Pfister, Stefan M., Paulus, Werner, Ram, Zvi, Schlesner, Matthias, Grossman, Rachel, and von Deimling, Andreas

Published
2017
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75. Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types

Author

Reinhardt, Annekathrin, primary, Pfister, Kristin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Sahm, Felix, additional, Reuss, David E., additional, Capper, David, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Sill, Martin, additional, Felsberg, Joerg, additional, Reifenberger, Guido, additional, Becker, Albert, additional, Prinz, Marco, additional, Staszewski, Ori, additional, Hartmann, Christian, additional, Schittenhelm, Jens, additional, Gramatzki, Dorothee, additional, Weller, Michael, additional, Olar, Adriana, additional, Rushing, Elisabeth Jane, additional, Bergmann, Markus, additional, Farrell, Michael A., additional, Blümcke, Ingmar, additional, Coras, Roland, additional, Beckervordersandforth, Jan, additional, Kim, Se Hoon, additional, Rogerio, Fabio, additional, Dimova, Petia S., additional, Niehusmann, Pitt, additional, Unterberg, Andreas, additional, Platten, Michael, additional, Pfister, Stefan M., additional, Wick, Wolfgang, additional, Herold‐Mende, Christel, additional, and von Deimling, Andreas, additional

Published
2022
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76. Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Author

Sahm, Felix, Korshunov, Andrey, Schrimpf, Daniel, Stichel, Damian, Jones, David T. W., Capper, David, Koelsche, Christian, Reuss, David, Kratz, Annekathrin, Huang, Kristin, Wefers, Annika K., Schick, Matthias, Bewerunge-Hudler, Melanie, Mittelbronn, Michel, Platten, Michael, Hänggi, Daniel, Jeibmann, Astrid, Unterberg, Andreas, Herold-Mende, Christel, Pfister, Stefan M., Brandner, Sebastian, Wick, Wolfgang, and von Deimling, Andreas

Published
2017
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77. Abstract 2491: Molecular and clinical characterization of the new WHO entity ‘Astroblastoma, MN1 altered’ and its molecular subgroups

Author

Schmitt-Hoffner, Felix, primary, Gojo, Johannes, additional, Mauermann, Monika, additional, von Hoff, Katja, additional, Sill, Martin, additional, Korshunov, Andrey, additional, Stichel, Damian, additional, Sahm, Felix, additional, Jäger, Natalie, additional, Pfister, Stefan, additional, and Kool, Marcel, additional

Published
2022
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78. RARE-15. Astroblastoma, MN1 altered comprises two molecularly and clinically distinct subgroups defined by the fusion partners BEND2 and CXXC5

Author

Schmitt-Hoffner, Felix, primary, Gojo, Johannes, additional, Mauermann, Monika, additional, von Hoff, Katja, additional, Sill, Martin, additional, Stichel, Damian, additional, Capper, David, additional, Tauziede-Espariat, Arnault, additional, Varlet, Pascale, additional, Aldape, Kenneth, additional, Abdullaev, Zied, additional, Donson, Andrew M, additional, Schüller, Ulrich, additional, Snuderl, Matija, additional, Brandner, Sebastian, additional, Łastowska, Maria, additional, Trubicka, Joanna, additional, Miele, Evelina, additional, van der Lugt, Jasper, additional, Bunt, Jens, additional, Kramm, Christof, additional, Zapotocky, Michal, additional, Sahm, Felix, additional, Korshunov, Andrey, additional, Jäger, Natalie, additional, Pfister, Stefan M, additional, and Kool, Marcel, additional

Published
2022
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79. PATH-03. Clinically Tractable Outcome Prediction of Group 3/4 Medulloblastoma Based on TPD52 Immunohistochemistry: a Multicohort Study

Author

Delaidelli, Alberto, primary, Dunham, Christopher, additional, Santi, Mariarita, additional, Negri, Gian Luca, additional, Triscott, Joanna, additional, Zheludkova, Olga, additional, Golanov, Andrey, additional, Ryzhova, Marina, additional, Okonechnikov, Konstantin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Ellison, David, additional, von Deimling, Andreas, additional, Kool, Marcel, additional, Pfister, Stefan, additional, Ramaswamy, Vijay, additional, Taylor, Michael, additional, Korshunov, Andrey, additional, and Sorensen, Poul, additional

Published
2022
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80. OTHR-41. Amplification of the PLAG family genes – PLAGL1 and PLAGL2 – is a key feature of a novel embryonal CNS tumor type

Author

Keck, Michaela-Kristina, primary, Sill, Martin, additional, Wittmann, Andrea, additional, Kumar, Piyush Joshi, additional, Stichel, Damian, additional, Sievers, Philipp, additional, Wefers, Annika K, additional, Roncaroli, Federico, additional, Hayden, James, additional, McCabe, Martin G, additional, Kranendonk, Mariëtte E G, additional, Zapotocky, Michal, additional, Vasiljevic, Alexandre, additional, Schüller, Ulrich, additional, Sturm, Dominik, additional, Blattner-Johnson, Mirjam, additional, von Deimling, Andreas, additional, Korshunov, Andrey, additional, Sahm, Felix, additional, Perry, Arie, additional, Solomon, David, additional, Pfister, Stefan, additional, and Jones, David T W, additional

Published
2022
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81. ETMR-06. Molecular and clinical characteristics of CNS tumors withBCOR(L1) fusion/internal tandem duplication

Author

Gojo, Johannes, primary, Schmitt-Hoffner, Felix, additional, Mauermann, Monika, additional, von Hoff, Katja, additional, Sill, Martin, additional, Korshunov, Andrey, additional, Stichel, Damian, additional, Capper, David, additional, Tauziede-Espariat, Arnault, additional, Varlet, Pascale, additional, Aldape, Kenneth, additional, Abdullaev, Zied, additional, Donson, Andrew, additional, Pahnke, Jens, additional, Schüller, Ulrich, additional, Tran, Ivy, additional, Galbraith, Kristyn, additional, Snuderl, Matija, additional, Alexandrescu, Sanda, additional, Brandner, Sebastian, additional, Łastowska, Maria, additional, Miele, Evelina, additional, Lugt, Jasper v, additional, Meijer, Lisethe, additional, Bunt, Jens, additional, Kramm, Christof, additional, Hansford, Jordan R, additional, Krskova, Lenka, additional, Zapotocky, Michal, additional, Nobusawa, Sumihito, additional, Solomon, David, additional, Haberler, Christine, additional, Jones, Barbara, additional, Sturm, Dominik, additional, Sahm, Felix, additional, Jäger, Natalie, additional, Pfister, Stefan M, additional, and Kool, Marcel, additional

Published
2022
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82. HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma

Author

Felix, Marius, primary, Friedel, Dennis, additional, Jayavelu, Ashok Kumar, additional, Filipski, Katharina, additional, Reinhardt, Annekathrin, additional, Warnken, Uwe, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Korshunov, Andrey, additional, Wang, Yueting, additional, Kessler, Tobias, additional, Etminan, Nima, additional, Unterberg, Andreas, additional, Herold-Mende, Christel, additional, Heikaus, Laura, additional, Sahm, Felix, additional, Wick, Wolfgang, additional, Harter, Patrick N, additional, von Deimling, Andreas, additional, and Reuss, David E, additional

Published
2022
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83. Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

Author

Afd Pharmaceutics, Pharmaceutics, Keller, Kaylee M., Krausert, Sonja, Gopisetty, Apurva, Luedtke, Dan, Koster, Jan, Schubert, Nil A., Rodríguez, Ana, van Hooff, Sander R., Stichel, Damian, Dolman, M. Emmy M., Vassal, Gilles, Pfister, Stefan M., Caron, Hubert N., Stancato, Louis F., Molenaar, Jan J., Jäger, Natalie, Kool, Marcel, Afd Pharmaceutics, Pharmaceutics, Keller, Kaylee M., Krausert, Sonja, Gopisetty, Apurva, Luedtke, Dan, Koster, Jan, Schubert, Nil A., Rodríguez, Ana, van Hooff, Sander R., Stichel, Damian, Dolman, M. Emmy M., Vassal, Gilles, Pfister, Stefan M., Caron, Hubert N., Stancato, Louis F., Molenaar, Jan J., Jäger, Natalie, and Kool, Marcel

Published
2022

84. Oligosarcomas, IDH‑mutant are distinct and aggressive

Author

Suwala, Abigail K., Felix, Marius, Friedel, Dennis, Stichel, Damian, Schrimpf, Daniel, Hinz, Felix, Hewer, Ekkehard, Schweizer, Leonille, Dohmen, Hildegard, Pohl, Ute, Staszewski, Ori, Korshunov, Andrey, Stein, Marco, Wongsurawat, Thidathip, Cheunsuacchon, Pornsuk, Sathornsumetee, Sith, Koelsche, Christian, Turner, Clinton, Rhun, Emilie Le, Mühlebner, Angelika, Schucht, Philippe, Özduman, Koray, Ono, Takahiro, Shimizu, Hiroaki, Prinz, Marco, Acker, Till, Herold‑Mende, Christel, Kessler, Tobias, Wick, Wolfgang, Capper, David, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, Reuss, David E., Suwala, Abigail K., Felix, Marius, Friedel, Dennis, Stichel, Damian, Schrimpf, Daniel, Hinz, Felix, Hewer, Ekkehard, Schweizer, Leonille, Dohmen, Hildegard, Pohl, Ute, Staszewski, Ori, Korshunov, Andrey, Stein, Marco, Wongsurawat, Thidathip, Cheunsuacchon, Pornsuk, Sathornsumetee, Sith, Koelsche, Christian, Turner, Clinton, Rhun, Emilie Le, Mühlebner, Angelika, Schucht, Philippe, Özduman, Koray, Ono, Takahiro, Shimizu, Hiroaki, Prinz, Marco, Acker, Till, Herold‑Mende, Christel, Kessler, Tobias, Wick, Wolfgang, Capper, David, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, and Reuss, David E.

Abstract

Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. In the past, case reports and small studies described gliomas with sarcomatous features arising from oligodendrogliomas, so called oligosarcomas. Here, we report a series of 24 IDH-mutant oligosarcomas from 23 patients forming a distinct methylation class. The tumors were recurrences from prior oligodendrogliomas or developed de novo. Precursor tumors of 12 oligosarcomas were histologically and molecularly indistinguishable from conventional oligodendrogliomas. Oligosarcoma tumor cells were embedded in a dense network of reticulin fibers, frequently showing p53 accumulation, positivity for SMA and CALD1, loss of OLIG2 and gain of H3K27 trimethylation (H3K27me3) as compared to primary lesions. In 5 oligosarcomas no 1p/19q codeletion was detectable, although it was present in the primary lesions. Copy number neutral LOH was determined as underlying mechanism. Oligosarcomas harbored an increased chromosomal copy number variation load with frequent CDKN2A/B deletions. Proteomic profiling demonstrated oligosarcomas to be highly distinct from conventional CNS WHO grade 3 oligodendrogliomas with consistent evidence for a smooth muscle differentiation. Expression of several tumor suppressors was reduced with NF1 being lost frequently. In contrast, oncogenic YAP1 was aberrantly overexpressed in oligosarcomas. Panel sequencing revealed mutations in NF1 and TP53 along with IDH1/2 and TERT promoter mutations. Survival of patients was significantly poorer for oligosarcomas as first recurrence than for grade 3 oligodendrogliomas as first recurrence. These results establish oligosarcomas as a distinct group of IDH-mutant gliomas differing from conventional oligodendrogliomas on the histologic, epigenetic, proteomic, molecular and clinical level. The diagnosis can be based on the combined presence of (a) sarcomatous histology, (b) IDH-mutation and

Published
2022

86. Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

Author

Keller, Kaylee M., primary, Krausert, Sonja, additional, Gopisetty, Apurva, additional, Luedtke, Dan, additional, Koster, Jan, additional, Schubert, Nil A., additional, Rodríguez, Ana, additional, van Hooff, Sander R., additional, Stichel, Damian, additional, Dolman, M. Emmy M., additional, Vassal, Gilles, additional, Pfister, Stefan M., additional, Caron, Hubert N., additional, Stancato, Louis F., additional, Molenaar, Jan J., additional, Jäger, Natalie, additional, and Kool, Marcel, additional

Published
2022
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87. Additional file 3 of Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

Author

Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N., Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Bel��n M., Suwala, Abigail, Wefers, Annika K., Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M., Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M., Sill, Martin, Jones, David T. W., Schrimpf, Daniel, Reuss, David E., Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, and Stichel, Damian

Abstract

Additional file 3. Composition of cohorts mcPXA and histPXA in numbers.

Published
2022
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88. Additional file 5 of Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

Author

Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N., Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Bel��n M., Suwala, Abigail, Wefers, Annika K., Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M., Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M., Sill, Martin, Jones, David T. W., Schrimpf, Daniel, Reuss, David E., Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, and Stichel, Damian

Abstract

Additional file 5. Histological features observed in pleomorphic xanthoastrocytomas, (a) classical giant pleomorphic cells with multiple nuclei and prominent nucleolus, (b) extensive perivascular inflammatory infiltrates, (c) endothelial proliferations, (d) extensive myxoid matrix, (e) pseudopalisading necrosis, (f) pseudopapillary growth pattern, (g) biphasic pattern with spindle cell component and giant pleomorphic cell component, (h) extensive calcification, (i) small round blue cell morphology, (j) a thrombosed vessel; all depicted tumors had a maximum calibrated score above 0.9 for mcPXA; Supplementary figure 2 Overall survival (Kaplan-Meier curve) of patients in cohort mcPXA stratified after initial histological diagnosis (a) and BRAF V600E status (b); Supplementary figure 3 Typical copy number profile of mcPXA (upper panel) compared to that of mcGBM (lower panel); Supplementary figure 4 Copy number summary of cohort mcPXA altogether and stratified after WHO grade; Supplementary figure 5: The composition of cohorts histPXA and mcPXA, (a) 220 mcPXA cases with their histological composition, (b) 144 histPXA cases with their methylation class assignments (v11b4).

Published
2022
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89. Additional file 6 of Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

Author

Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N., Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Bel��n M., Suwala, Abigail, Wefers, Annika K., Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M., Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M., Sill, Martin, Jones, David T. W., Schrimpf, Daniel, Reuss, David E., Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, and Stichel, Damian

Subjects
TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Data_FILES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional file 6. List of abbreviations.

Published
2022
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90. Additional file 4 of Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival

Author

Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N., Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Bel��n M., Suwala, Abigail, Wefers, Annika K., Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M., Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M., Sill, Martin, Jones, David T. W., Schrimpf, Daniel, Reuss, David E., Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, and Stichel, Damian

Abstract

Additional file 4. tSNE plot of histPXA cases with the set of reference samples underlying the classifier version v11b4; ���histPXA a��� represents cases with a calibrated score less than 0.9 in v11b4 classifier, ���histPXA b��� represents cases with a calibrated score of 0.9 or higher in v11b4 classifier.

Published
2022
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93. Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study

Author

Delaidelli, Alberto, primary, Dunham, Christopher, additional, Santi, Mariarita, additional, Negri, Gian Luca, additional, Triscott, Joanna, additional, Zheludkova, Olga, additional, Golanov, Andrey, additional, Ryzhova, Marina, additional, Okonechnikov, Konstantin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Ellison, David W., additional, von Deimling, Andreas, additional, Kool, Marcel, additional, Pfister, Stefan M., additional, Ramaswamy, Vijay, additional, Korshunov, Andrey, additional, Taylor, Michael D., additional, and Sorensen, Poul H., additional

Published
2022
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94. Oligosarcomas, IDH-mutant are distinct and aggressive

Author

Suwala, Abigail K., primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hinz, Felix, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Staszewski, Ori, additional, Korshunov, Andrey, additional, Stein, Marco, additional, Wongsurawat, Thidathip, additional, Cheunsuacchon, Pornsuk, additional, Sathornsumetee, Sith, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Le Rhun, Emilie, additional, Mühlebner, Angelika, additional, Schucht, Philippe, additional, Özduman, Koray, additional, Ono, Takahiro, additional, Shimizu, Hiroaki, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Kessler, Tobias, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David E., additional

Published
2021
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95. PATH-48. RAPID-CNS2: RAPID COMPREHENSIVE ADAPTIVE NANOPORE-SEQUENCING OF CNS TUMORS, A PROOF OF CONCEPT STUDY

Author

Patel, Areeba, primary, Dogan, Helin, additional, Payne, Alexander, additional, Sievers, Philipp, additional, Schoebe, Natalie, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Holmes, Nadine, additional, Euskirchen, Philipp, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Rosenstiel-Goidts, Violaine, additional, Dieterich, Christoph, additional, Herold-Mende, Christel, additional, Pfister, Stefan, additional, Wick, Wolfgang, additional, Schlesner, Matthias, additional, Loose, Matthew, additional, Jones, David, additional, von Deimling, Andreas, additional, Sill, Martin, additional, and Sahm, Felix, additional

Published
2021
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96. PATH-23. OLIGOSARCOMA, IDH-MUTANT IS A DISTINCT AGGRESSIVE TYPE

Author

Suwala, Abigail K, primary, Felix, Marius, additional, Friedel, Dennis, additional, Stichel, Damian, additional, Schrimpf, Daniel, additional, Hewer, Ekkehard, additional, Schweizer, Leonille, additional, Dohmen, Hildegard, additional, Pohl, Ute, additional, Erny, Daniel, additional, Koelsche, Christian, additional, Turner, Clinton, additional, Özduman, Koray, additional, Prinz, Marco, additional, Acker, Till, additional, Herold-Mende, Christel, additional, Wick, Wolfgang, additional, Capper, David, additional, Wesseling, Pieter, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Hartmann, Christian, additional, and Reuss, David, additional

Published
2021
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97. PATH-39. INTEGRATED MOLECULAR-MORPHOLOGICAL MENINGIOMA CLASSIFICATION: A MULTICENTER RETROSPECTIVE ANALYSIS, RETRO- AND PROSPECTIVELY VALIDATED

Author

Maas, Sybren, primary, Stichel, Damian, additional, Hielscher, Thomas, additional, Sievers, Philipp, additional, Berghoff, Anna, additional, Schrimpf, Daniel, additional, Sill, Martin, additional, Euskirchen, Philipp, additional, Reuss, David, additional, Dohmen, Hildegard, additional, Stein, Marco, additional, Baumgarten, Peter, additional, Ricklefs, Franz, additional, Rushing, Elizabeth, additional, Bewerunge-Hudler, Melanie, additional, Ketter, Ralf, additional, Schittenhelm, Jens, additional, Jaunmuktane, Zane, additional, Leu, Severina, additional, Grady, Conor, additional, Serrano, Jonathan, additional, Golfinos, John, additional, Sen, Chandra, additional, Mawrin, Christian, additional, Jungk, Christine, additional, Hänggi, Daniel, additional, Westphal, Manfred, additional, Lamszus, Katrin, additional, Etminan, Nima, additional, Unterberg, Andreas, additional, Harter, Patrick, additional, Wirsching, Hans-Georg, additional, Neidert, Marian Christoph, additional, Ratliff, Miriam, additional, Platten, Michael, additional, Snuderl, Matija, additional, Aldape, Kenneth, additional, Brandner, Sebastian, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Pfister, Stefan, additional, Jones, David, additional, Reifenberger, Guido, additional, Acker, Till, additional, Wick, Wolfgang, additional, Weller, Michael, additional, Preusser, Matthias, additional, von Deimling, Andreas, additional, and Sahm, Felix, additional

Published
2021
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98. Local ablative treatment with surgery and/or radiotherapy in single-site and oligometastatic carcinoma of unknown primary

Author

Pouyiourou, Maria, primary, Wohlfromm, Timothy, additional, Kraft, Bianca, additional, Hielscher, Thomas, additional, Stichel, Damian, additional, von Deimling, Andreas, additional, Delorme, Stefan, additional, Endris, Volker, additional, Neumann, Olaf, additional, Stenzinger, Albrecht, additional, Krämer, Alwin, additional, and Bochtler, Tilmann, additional

Published
2021
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99. Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

Author

Keller, Kaylee M., Krausert, Sonja, Gopisetty, Apurva, Luedtke, Dan, Koster, Jan, Schubert, Nil A., Rodríguez, Ana, van Hooff, Sander R., Stichel, Damian, Dolman, M. Emmy M., Vassal, Gilles, Pfister, Stefan M., Caron, Hubert N., Stancato, Louis F., Molenaar, Jan J., Jäger, Natalie, Kool, Marcel, Afd Pharmaceutics, Pharmaceutics, Afd Pharmaceutics, and Pharmaceutics

Subjects
Paediatric oncology, Cancer Research, DNA Repair, DNA repair, Replication stress, Bone Neoplasms, Cell Cycle Checkpoints, Oncology, Preclinical research, Cell cycle checkpoints, Systematic review, Humans, Targeted drugs, Cerebellar Neoplasms, Child, Medulloblastoma
Abstract

Background: Owing to the high numbers of paediatric cancer-related deaths, advances in therapeutic options for childhood cancer is a heavily studied field, especially over the past decade. Classical chemotherapy offers some therapeutic benefit but has proven long-term complications in survivors, and there is an urgent need to identify novel target-driven therapies. Replication stress is a major cause of genomic instability in cancer, triggering the stalling of the replication fork. Failure of molecular response by DNA damage checkpoints, DNA repair mechanisms and restarting the replication forks can exacerbate replication stress and initiate cell death pathways, thus presenting as a novel therapeutic target. To bridge the gap between preclinical evidence and clinical utility thereof, we apply the literature-driven systematic target actionability review methodology to published proof-of-concept (PoC) data related to the process of replication stress. Methods: A meticulous PubMed literature search was performed to gather replication stress-related articles (published between 2014 and 2021) across 16 different paediatric solid tumour types. Articles that fulfilled inclusion criteria were uploaded into the R2 informatics platform [r2.amc.nl] and assessed by critical appraisal. Key evidence based on nine pre-established PoC modules was summarised, and scores based on the quality and outcome of each study were assigned by two separate reviewers. Articles with discordant modules/scores were re-scored by a third independent reviewer, and a final consensus score was agreed upon by adjudication between all three reviewers. To visualise the final scores, an interactive heatmap summarising the evidence and scores associated with each PoC module across all, including paediatric tumour types, were generated. Results and conclusions:: 145 publications related to targeting replication stress in paediatric tumours were systematically reviewed with an emphasis on DNA repair pathways and cell cycle checkpoint control. Although various targets in these pathways have been studied in these diseases to different extents, the results of this extensive literature search show that ATR, CHK1, PARP or WEE1 are the most promising targets using either single agents or in combination with chemotherapy or radiotherapy in neuroblastoma, osteosarcoma, high-grade glioma or medulloblastoma. Targeting these pathways in other paediatric malignancies may work as well, but here, the evidence was more limited. The evidence for other targets (such as ATM and DNA-PK) was also limited but showed promising results in some malignancies and requires more studies in other tumour types. Overall, we have created an extensive overview of targeting replication stress across 16 paediatric tumour types, which can be explored using the interactive heatmap on the R2 target actionability review platform [https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=imi2_targetmap_v1].

Published
2021

100. Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, Ghasemi, David R, Okonechnikov, Konstantin, Korshunov, Andrey, Sill, Martin, Maass, Kendra K, da Silva, Patricia Benites Goncalves, Ryzhova, Marina, Gojo, Johannes, Stichel, Damian, Arabzade, Amir, Kupp, Robert, Benzel, Julia, Taya, Shinichiro, Adachi, Toma, Shiraishi, Ryo, Gerber, Nicolas U, Sturm, Dominik, Ecker, Jonas, Sievers, Philipp, Selt, Florian, Chapman, Rebecca, Haberler, Christine, Figarella-Branger, Dominique, Reifenberger, Guido, Fleischhack, Gudrun, Rutkowski, Stefan, Donson, Andrew M, Ramaswamy, Vijay, Capper, David, et al, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health, 2730 Oncology
Published
2021

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