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51. Ischemic Ventricular Tachycardia

Author

Lugo, Ricardo M., Kanagasundram, Arvindh, Stevenson, William G., Natale, Andrea, editor, Wang, Paul J., editor, Al-Ahmad, Amin, editor, and Estes, N. A. Mark, editor

Published
2020
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52. MOOCs and Joseph Lancaster: Lessons from a Two-Hundred Year Precedent in Mass Learning on a Global Scale

Author

Stevenson, William R., III

Abstract

Over the past three years, Massive Open Online Courses, or MOOCs, have spanned the globe, educating millions with the potential to reach millions more. Taught by leading academics from top institutions, the courses are as complete as those offered in traditional settings; yet, in being web-based and tuition free, they disregard long-standing geographic and economic barriers. These qualities have led many to see MOOCs as a significant step towards universal education and the fulfillment of the United Nation's goal of education as a human right. MOOCs, however, are not without precedent. As others have noted, the twentieth century witnessed several--generally unsuccessful--attempts at using film, radio, and television for large-scale learning. What has been mostly forgotten is that combining technology and methodology to increase efficiency and reach a "massive" number of students predates all of these examples. This study argues that the attempt to use technology for the purpose of mass education dates at least to the early nineteenth century with the educational system of Joseph Lancaster (1778-1838). Furthermore, the Lancasterian system was far more successful than most pre-MOOC applications of educational technology, having a profound and global impact. As such, the Lancasterian system deserves to be reevaluated in the context of recent developments and, as a predecessor to MOOCs, its successes and failures should serve as distant guideposts to further MOOC development.

Published
2015

54. The precordial R′ wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia

Author

Hoogendoorn, Jarieke C., Venlet, Jeroen, Out, Yannick N.J., Man, Sumche, Kumar, Saurabh, Sramko, Marek, Dechering, Dirk G., Nakajima, Ikutaro, Siontis, Konstantinos C., Watanabe, Masaya, Nakamura, Yoshinori, Tedrow, Usha B., Bogun, Frank, Eckardt, Lars, Peichl, Petr, Stevenson, William G., and Zeppenfeld, Katja

Published
2021
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55. The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect

Author

Woodford, Mark R., Baker-Williams, Alexander J., Sager, Rebecca A., Backe, Sarah J., Blanden, Adam R., Hashmi, Fiza, Kancherla, Priyanka, Gori, Alessandro, Loiselle, David R., Castelli, Matteo, Serapian, Stefano A., Colombo, Giorgio, Haystead, Timothy A., Jensen, Sandra M., Stetler-Stevenson, William G., Loh, Stewart N., Schmidt, Laura S., Linehan, W. Marston, Bah, Alaji, Bourboulia, Dimitra, Bratslavsky, Gennady, and Mollapour, Mehdi

Published
2021
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61. Prognostic Impact of the Timing of Recurrence of Infarct-Related Ventricular Tachycardia After Catheter Ablation

Author

Siontis, Konstantinos C, Kim, Hyungjin Myra, Stevenson, William G, Fujii, Akira, Bella, Paolo Della, Vergara, Pasquale, Shivkumar, Kalyanam, Tung, Roderick, Do, Duc H, Daoud, Emile G, Okabe, Toshimasa, Zeppenfeld, Katja, Riva Silva, Marta de, Hindricks, Gerhard, Arya, Arash, Weber, Alexander, Kuck, Karl-Heinz, Metzner, Andreas, Mathew, Shibu, Riedl, Johannes, Yokokawa, Miki, Jongnarangsin, Krit, Latchamsetty, Rakesh, Morady, Fred, and Bogun, Frank M

Subjects
Heart Disease, Cardiovascular, Aged, Catheter Ablation, Female, Heart Transplantation, Humans, Male, Myocardial Infarction, Prognosis, Recurrence, Tachycardia, Ventricular, Time Factors, Treatment Outcome, catheter ablation, myocardial infarction, prognosis, recurrence, ventricular tachycardia, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Medical Physiology, Cardiovascular System & Hematology
Abstract

Recurrence of ventricular tachycardia (VT) after ablation in patients with previous myocardial infarction is associated with adverse prognosis. However, the impact of the timing of VT recurrence on outcomes is unclear. We analyzed data from a multicenter collaborative database of patients who underwent catheter ablation for infarct-related VT. Multivariable Cox regression analyses investigated the effect of the timing of VT recurrence on the composite outcome of death or heart transplantation using VT recurrence as a time-varying covariate. A total of 1412 patients were included (92% men; age: 66.7±10.7 years), and 605 patients (42.8%) had a recurrence after median 116 days (188 [31.1%] within 1 month, 239 [39.5%] between 1 and 12 months, and 178 [29.4%] after 12 months). At median follow-up of 670 days, 375 patients (26.6%) experienced death or heart transplantation. The median time from recurrence to death or heart transplantation was 65 and 198.5 days in patients with recurrence ≤30 days and >30 days post ablation, respectively. The adjusted hazard ratio (95% confidence interval) for the effect of VT recurrence occurring immediately post ablation on death or heart transplantation was 3.45 (2.33-5.11) in reference to no recurrence. However, the magnitude of this effect decreased statistically significantly (P

Published
2016

62. Sarcoid Ventricular Tachycardia

Author

Lugo, Ricardo M., Kanagasundram, Arvindh, Stevenson, William G., Natale, Andrea, editor, Wang, Paul J., editor, Al-Ahmad, Amin, editor, and Estes, N. A. Mark, editor

Published
2020
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63. Unrelated Donor Transplant Recipients Given Thymoglobuline Have Superior GRFS When Compared to Matched Related Donor Recipients Undergoing Transplantation without ATG

Author

Othman, Jad, Greenwood, Matthew, Moore, John, Larsen, Stephen, Watson, Anne-Marie, Arthur, Chris, Bhattacharyya, Abir, Bilmon, Ian, Blyth, Emily, Bryant, Adam, Bryant, Christian, Dunlop, Lindsay, Fay, Keith, Gibson, John, Hamad, Nada, Kerridge, Ian, Kwan, John, Ma, David, Micklethwaite, Kenneth, Milliken, Samuel, Panicker, Shyam, Stevenson, William, Withers, Barbara, Wilcox, Leonie, Tran, Steven, and Gottlieb, David J.

Published
2020
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65. Can Intracardiac Echocardiography Reduce Steam Pops During Half-Normal Saline Irrigated Radiofrequency Ablation?

Author

Kanae Hasegawa, Yoneda, Zachary T., Martines-Parachini, Jose R., Powers, Edward M., Davogustto, Giovanni E., Hu, Tiffany Y., Kenichi Tokutake, Kurata, Masaaki, Richardson, Travis D., Montgomery, Jay A., Shen, Sharon, Estrada, Juan C., Saavedra, Pablo J., Emerson, Amy, Walker, Marilyn L., Tandri, Harikrishna, Michaud, Gregory F., Kanagasundram, Arvindh N., and Stevenson, William G.

Abstract

BACKGROUND: Irrigated radiofrequency ablation with half-normal saline can potentially increase lesion size but may increase the risk of steam pops with the risk of emboli or perforation. We hypothesized that pops would be preceded by intracardiac echocardiography (ICE) findings as well as a large impedance fall. METHODS: In 100 consecutive patients undergoing endocardial ventricular arrhythmia radiofrequency ablation with half-normal saline, we attempted to observe the ablation site with ICE. Radiofrequency ablation power was titrated to a 15 to 20 Ohm impedance fall and could be adjusted for tissue whitening and increasing bubble formation on ICE. Steam pops were defined as audible or a sudden explosion of microbubbles on ICE. RESULTS: Of 2190 ablation applications in 100 patients (82% cardiomyopathy, 50% sustained ventricular tachycardia), pops occurred during 43 (2.0%) applications. Sites with pops had greater impedance decreases of 18 [14, 21]% versus 13 [10, 17]% (P<0.001). ICE visualized 1308 (59.7%) radiofrequency sites, and fewer pops occurred when ICE visualized the radiofrequency ablation site (1.4%) compared with without ICE visualization (2.8%; P=0.016). Of the 18 ICE-visible pops, 7 (39%) were silent but recognized as an explosion of bubbles on ICE. With ICE, 89% of pops were preceded by either tissue whitening or a sudden increase in bubbles. In a multivariable model, tissue whitening and a sudden increase in bubbles were associated with steam pops (odds ratio, 7.186; P=0.004, and odds ratio, 29.93; P<0.001, respectively), independent of impedance fall and power. There were no pericardial effusions or embolic events with steam pops. CONCLUSIONS: Steam pops occurred in 2% of half-normal saline radiofrequency applications titrated to an impedance fall and are likely under-recognized without ICE. On ICE, steam pops are usually preceded by tissue whitening or a sudden increase in bubble formation, which can potentially be used to adjust radiofrequency application to help reduce pops. [ABSTRACT FROM AUTHOR]

Published
2024
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66. Christian Universities in Japan

Author

Stevenson, William R., III, Maclean, Rupert, Series Editor, Symaco, Lorraine Pe, Series Editor, Adamson, Bob, Editorial Board Member, Baker, Robyn, Editorial Board Member, Crossley, Michael, Editorial Board Member, Jagannathan, Shanti, Editorial Board Member, Kitamura, Yuto, Editorial Board Member, Power, Colin, Editorial Board Member, Thaman, Konai Helu, Editorial Board Member, Bray, Mark, Advisory Editor, Cheng, Yin Cheong, Advisory Editor, Fien, John, Advisory Editor, Huong, Pham Lan, Advisory Editor, Lee, Chong-Jae, Advisory Editor, Mar, Naing Yee, Advisory Editor, Masters, Geoff, Advisory Editor, Pavlova, Margarita, Advisory Editor, Walsh, Max, Advisory Editor, de Zoysa, Uchita, Advisory Editor, Jun, Alexander, editor, and Collins, Christopher S., editor

Published
2019
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73. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias

Author

Cronin, Edmond M., Bogun, Frank M., Maury, Philippe, Peichl, Petr, Chen, Minglong, Namboodiri, Narayanan, Aguinaga, Luis, Leite, Luiz Roberto, Al-Khatib, Sana M., Anter, Elad, Berruezo, Antonio, Callans, David J., Chung, Mina K., Cuculich, Phillip, d’Avila, Andre, Deal, Barbara J., Della Bella, Paolo, Deneke, Thomas, Dickfeld, Timm-Michael, Hadid, Claudio, Haqqani, Haris M., Kay, G. Neal, Latchamsetty, Rakesh, Marchlinski, Francis, Miller, John M., Nogami, Akihiko, Patel, Akash R., Pathak, Rajeev Kumar, Saenz Morales, Luis C., Santangeli, Pasquale, Sapp, John L., Jr., Sarkozy, Andrea, Soejima, Kyoko, Stevenson, William G., Tedrow, Usha B., Tzou, Wendy S., Varma, Niraj, and Zeppenfeld, Katja

Published
2020
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76. Catheter ablation of ventricular tachycardia: Lessons learned from past clinical trials and implications for future clinical trials

Author

Pokorney, Sean D, Friedman, Daniel J, Calkins, Hugh, Callans, David J, Daoud, Emile G, Della-Bella, Paolo, Jackson, Kevin P, Shivkumar, Kalyanam, Saba, Samir, Sapp, John, Stevenson, William G, and Al-Khatib, Sana M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Trials and Supportive Activities, Patient Safety, Heart Disease, Cardiovascular, Rare Diseases, Clinical Research, Good Health and Well Being, Catheter Ablation, Clinical Trials as Topic, Humans, Recurrence, Tachycardia, Ventricular, Ventricular tachycardia, Catheter ablation, Implantable cardioverter-defibrillator, Clinical trials, Appropriate shock, Antitachycardia pacing, Mortality, Biomedical Engineering, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Catheter ablation of ventricular tachycardia (VT) has evolved in recent years, especially in patients with ischemic heart disease. Data from prospective studies show that VT catheter ablation reduces the risk of recurrent VT; however, there is a paucity of data on the effect of VT catheter ablation on mortality and patient-centered outcomes such as quality of life. Performing randomized clinical trials of VT catheter ablation can be fraught with challenges, and, as a result, several prior trials of VT catheter ablation had to be stopped prematurely. The main challenges are inability to blind the patient to therapy to obtain a traditional control group, high crossover rates between the 2 arms of the study, patient refusal to participate in trials in which they have an equal chance of receiving a "pill" vs an invasive procedure, heterogeneity of mapping and ablation techniques as well as catheters and equipment, rapid evolution of technology that may make findings of any long trial less relevant to clinical practice, lack of consensus on what constitutes acute procedural and long-term success, and presentation of patients to electrophysiologists late in the course of their disease. In this article, a panel of experts on VT catheter ablation and/or clinical trials of VT catheter ablation review challenges faced in conducting prior trials of VT catheter ablation and offer potential solutions for those challenges. It is hoped that the proposed solutions will enhance the feasibility of randomized clinical trials of VT catheter ablation.

Published
2016

78. 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary

Author

Cronin, Edmond M., Bogun, Frank M., Maury, Philippe, Peichl, Petr, Chen, Minglong, Namboodiri, Narayanan, Aguinaga, Luis, Leite, Luiz Roberto, Al-Khatib, Sana M., Anter, Elad, Berruezo, Antonio, Callans, David J., Chung, Mina K., Cuculich, Phillip, d’Avila, Andre, Deal, Barbara J., Della Bella, Paolo, Deneke, Thomas, Dickfeld, Timm-Michael, Hadid, Claudio, Haqqani, Haris M., Kay, G. Neal, Latchamsetty, Rakesh, Marchlinski, Francis, Miller, John M., Nogami, Akihiko, Patel, Akash R., Pathak, Rajeev Kumar, Saenz Morales, Luis C., Santangeli, Pasquale, Sapp, Jr, John L., Sarkozy, Andrea, Soejima, Kyoko, Stevenson, William G., Tedrow, Usha B., Tzou, Wendy S., Varma, Niraj, and Zeppenfeld, Katja

Published
2020
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82. Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study

Author

Tung, Roderick, Vaseghi, Marmar, Frankel, David S, Vergara, Pasquale, Di Biase, Luigi, Nagashima, Koichi, Yu, Ricky, Vangala, Sitaram, Tseng, Chi-Hong, Choi, Eue-Keun, Khurshid, Shaan, Patel, Mehul, Mathuria, Nilesh, Nakahara, Shiro, Tzou, Wendy S, Sauer, William H, Vakil, Kairav, Tedrow, Usha, Burkhardt, J David, Tholakanahalli, Venkatakrishna N, Saliaris, Anastasios, Dickfeld, Timm, Weiss, J Peter, Bunch, T Jared, Reddy, Madhu, Kanmanthareddy, Arun, Callans, David J, Lakkireddy, Dhanunjaya, Natale, Andrea, Marchlinski, Francis, Stevenson, William G, Della Bella, Paolo, and Shivkumar, Kalyanam

Subjects
Cardiovascular, Transplantation, Heart Disease, Good Health and Well Being, Aged, Body Surface Potential Mapping, Cardiomyopathies, Catheter Ablation, Defibrillators, Implantable, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Recurrence, Retrospective Studies, Survival Rate, Tachycardia, Ventricular, United States, Ablation, Ventricular tachycardia, Biomedical Engineering, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

BackgroundThe impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown.ObjectiveThe purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT.MethodsAnalysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality.ResultsOne-year freedom from VT recurrence was 70% (72% in ischemic and 68% in nonischemic cardiomyopathy). Fifty-seven patients (3%) underwent cardiac transplantation, and 216 (10%) died during follow-up. At 1 year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and nonischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence than in those with recurrence (90% vs 71%, P

Published
2015

84. 3178 – LONGITUDINAL DRUG INCORPORATION, CLONAL COMPOSITION, AND DNA METHYLATION DYNAMICS IN MDS/CMML PATIENTS TREATED WITH AZA

Author

Thoms, Julie, Hampton, Henry, Yan, Feng, Davidson, Sarah, Joshi, Swapna, Sarowar, Chowdhury, Lim, Xin Ying, Nunez, Andrea, Kakadia, Purvi, Saw, Jesslyn, Bhuyan, Golam Sarower, Zou, Xiaoheng, Ghodousi, Elaheh, Jolly, Christopher, Koch, Forrest, Vafaee, Fatemeh, Pickford, Russell, Raftery, Mark, Hough, Sally, Buckland, Griselda, Bailey, Michelle, Ghodke, Yuvaraj, Absar, Noorul, Vaughan, Lachlin, Pasalic, Leonardo, Fong, Chun, Kenealy, Melita, Hiwase, Devendra, Stoddart, Rohanna, Mohammed, Soma, Lee, Linda, Passam, Freda, Spring, Kevin, Skarratt, Kristen, Rebeiro, Patricia, Larsen, Stephen, Presgrave, Peter, Stevenson, William, Ling, Silvia, Tiley, Campbell, Fuller, Stephen, Roncolato, Fernando, Enjeti, Anoop, Hoenemann, Dirk, Lemech, Charlotte, Curtis, David, Bohlander, Stefan, Olivier, Jake, Hertzberg, Mark, Unnikrishnan, Ashwin, Polizotto, Mark, and Pimanda, John

Published
2024
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88. Ablation compared with drug therapy for recurrent ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy: Results from a multicenter study

Author

Mahida, Saagar, Venlet, Jeroen, Saguner, Ardan Muammer, Kumar, Saurabh, Baldinger, Samuel H., AbdelWahab, Amir, Tedrow, Usha B., Castelletti, Silvia, Pantazis, Antonis, John, Roy M., McKenna, William J., Lambiase, Pier D., Duru, Firat, Sapp, John L., Zeppenfeld, Katja, and Stevenson, William G.

Published
2019
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90. Endpoints for Successful Slow Pathway Catheter Ablation in Typical and Atypical Atrioventricular Nodal Re-Entrant Tachycardia: A Contemporary, Multicenter Study

Author

Katritsis, Demosthenes G., Zografos, Theodoros, Siontis, Konstantinos C., Giannopoulos, George, Muthalaly, Rahul G., Liu, Qiang, Latchamsetty, Rakesh, Varga, Zoltán, Deftereos, Spyridon, Swerdlow, Charles, Callans, David J., Miller, John M., Morady, Fred, John, Roy M., and Stevenson, William G.

Published
2019
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94. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Author

Al-Khatib, Sana M., Stevenson, William G., Ackerman, Michael J., Bryant, William J., Callans, David J., Curtis, Anne B., Deal, Barbara J., Dickfeld, Timm, Field, Michael E., Fonarow, Gregg C., Gillis, Anne M., Granger, Christopher B., Hammill, Stephen C., Hlatky, Mark A., Joglar, José A., Kay, G. Neal, Matlock, Daniel D., Myerburg, Robert J., and Page, Richard L.

Published
2018
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95. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Author

Al-Khatib, Sana M., Stevenson, William G., Ackerman, Michael J., Bryant, William J., Callans, David J., Curtis, Anne B., Deal, Barbara J., Dickfeld, Timm, Field, Michael E., Fonarow, Gregg C., Gillis, Anne M., Granger, Christopher B., Hammill, Stephen C., Hlatky, Mark A., Joglar, José A., Kay, G. Neal, Matlock, Daniel D., Myerburg, Robert J., and Page, Richard L.

Published
2018
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96. The TIMP protein family: diverse roles in pathophysiology.

Author

Coates-Park, Sasha, Rich, Joshua A., Stetler-Stevenson, William G., and Peeney, David

Subjects
TISSUE inhibitors of metalloproteinases, PATHOLOGICAL physiology, PROTEINS, METALLOPROTEINASES
Abstract

The tissue inhibitors of matrix metalloproteinases (TIMPs) are a family of four matrisome proteins classically defined by their roles as the primary endogenous inhibitors of metalloproteinases (MPs). Their functions however are not limited to MP inhibition, with each family member harboring numerous MP-independent biological functions that play key roles in processes such as inflammation and apoptosis. Because of these multifaceted functions, TIMPs have been cited in diverse pathophysiological contexts. Herein, we provide a comprehensive overview of the MP-dependent and -independent roles of TIMPs across a range of pathological conditions. The potential therapeutic and biomarker applications of TIMPs in these disease contexts are also considered, highlighting the biomedical promise of this complex and often misunderstood protein family. [ABSTRACT FROM AUTHOR]

Published
2024
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100. Presumed Ocular Histoplasmosis Syndrome

Author

Stevenson, William, primary, Alvarez, Erica, additional, Mallick, Adnan, additional, Yanoga, Fatoumata, additional, Davidorf, Frederick, additional, and Cebulla, Colleen M., additional

Published
2020
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