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55. Early life involvement in C9orf72 repeat expansion carriers

Author

Genetica Klinische Genetica, Gossink, Flora, Dols, Annemiek, Stek, Max L, Scheltens, Philip, Nijmeijer, Bas, Cohn Hokke, Petra, Dijkstra, Anke, Van Ruisssen, Fred, Aalfs, Cora, Pijnenburg, Yolande A L, Genetica Klinische Genetica, Gossink, Flora, Dols, Annemiek, Stek, Max L, Scheltens, Philip, Nijmeijer, Bas, Cohn Hokke, Petra, Dijkstra, Anke, Van Ruisssen, Fred, Aalfs, Cora, and Pijnenburg, Yolande A L

Published
2022

73. The Association Between Loneliness and Psychiatric Symptomatology in Older Psychiatric Outpatients.

Author

Schutter, Natasja, Holwerda, Tjalling J, Kuipers, Hanna, Van, Rien H. L., Stek, Max L., Comijs, Hannie C., Peen, Jaap, and Dekker, Jack J M.

Subjects
LONELINESS, PEOPLE with mental illness, SOCIAL isolation, SOCIAL interaction, OLDER patients, SOCIAL networks
Abstract

purpose: Loneliness in adults increases with age. Although loneliness has been found to be associated with psychiatric disorders and dementia, no information is available on prevalence of loneliness in older psychiatric patients. The aims of this study were to examine prevalence of loneliness in older psychiatric outpatients, including gender differences and associations with psychiatric disorders and social isolation. Methods: Cross-sectional study in an outpatient clinic for geriatric psychiatry between September 2013 and February 2018. Interviews were done in 181 patients. Results: 80% of participants were lonely. Loneliness was associated with having contacts in less social network domains, in women but not in men. There were no associations with DSM-IV-TR-classifications. However, loneliness was associated with higher scores on questionnaires for depression and cognitive function. Intensity of treatment did not differ significantly between lonely and non-lonely participants. Conclusion: Loneliness is highly prevalent in older psychiatric outpatients, with men and women equally affected. Loneliness should be assessed in all older psychiatric patients, especially when they show high scores on symptom checklists or have a restricted social network. [ABSTRACT FROM AUTHOR]

Published
2022
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75. Inflammation and Cognitive Functioning in Depressed Older Adults Treated With Electroconvulsive Therapy

Author

Carlier, Angela, primary, Rhebergen, Didi, additional, Veerhuis, Robert, additional, Schouws, Sigfried, additional, Oudega, Mardien L., additional, Eikelenboom, Piet, additional, Bouckaert, Filip, additional, Sienaert, Pascal, additional, Obbels, Jasmien, additional, Stek, Max L., additional, Exel, Eric van, additional, and Dols, Annemiek, additional

Published
2021
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77. A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Author

Onderzoek, Brain, Hersenen-Medisch 1, Onderzoeksgroep 11, Lange, Sjors M M, Schirmbeck, Frederike, Stek, Max L, Murk Jansen, Yentl R, van Rooijen, Geeske, de Haan, Lieuwe, Penninx, Brenda W J H, Rhebergen, Didi, GROUP Investigators, Onderzoek, Brain, Hersenen-Medisch 1, Onderzoeksgroep 11, Lange, Sjors M M, Schirmbeck, Frederike, Stek, Max L, Murk Jansen, Yentl R, van Rooijen, Geeske, de Haan, Lieuwe, Penninx, Brenda W J H, Rhebergen, Didi, and GROUP Investigators

Published
2021

80. Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease

Author

van Exel, Eric, Eikelenboom, Piet, Comijs, Hannie, Frolich, Marijke, Smit, Johannes H., Stek, Max L., Scheltens, Philip, Eefsting, Jan E., and Westendorp, Rudi G.J.

Subjects
Alzheimer's disease -- Development and progression, Alzheimer's disease -- Research, Amyloid beta-protein -- Physiological aspects, Amyloid beta-protein -- Research, Health, Psychology and mental health
Published
2009

82. Early life involvement in C9orf72 repeat expansion carriers

Author

Gossink, Flora, primary, Dols, Annemiek, additional, Stek, Max L, additional, Scheltens, Philip, additional, Nijmeijer, Bas, additional, Cohn Hokke, Petra, additional, Dijkstra, Anke, additional, Van Ruissen, Fred, additional, Aalfs, Cora, additional, and Pijnenburg, Yolande A L, additional

Published
2021
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83. A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder

Author

Lange, Sjors M.M., primary, Schirmbeck, Frederike, additional, Stek, Max L., additional, Murk Jansen, Yentl R., additional, van Rooijen, Geeske, additional, de Haan, Lieuwe, additional, Penninx, Brenda W.J.H., additional, Rhebergen, Didi, additional, Amelsvoort, Therese van, additional, Bartels-Velthuis, Agna A., additional, Bruggeman, Richard, additional, Cahn, Wiepke, additional, Kahn, Rene S., additional, Simons, Claudia J.P., additional, and van Os, Jim, additional

Published
2021
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84. FindMyApps: Protocol for a randomized controlled trial with community-dwelling people with dementia, evaluating the effectiveness and cost-effectiveness of an intervention to improve self-management and social participation

Author

Neal, David P., Kerkhof, Yvonne J. F., Ettema, Teake P., Muller, Majon, Bosmans, Judith, Finnema, Evelyn, Graff, Maud, Tanja-Dijkstra, Karin, Stek, Max L., Droes, Rose-Marie, Neurology, Psychiatry, APH - Mental Health, Internal medicine, ACS - Atherosclerosis & ischemic syndromes, APH - Aging & Later Life, and APH - Methodology

Published
2020

85. Supplemental Material, Sociodemographic_apathy_scores_sites_2sep2019 - Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Author

Mardien Leoniek Oudega, Amna Siddiqui, Wattjes, Mike P., Barkhof, Frederik, Kate, Mara Ten, Majon Muller, Bouckaert, Filip, Vandenbulcke, Mathieu, François-Laurent De Winter, Sienaert, Pascal, Stek, Max L., Comijs, Hannie C., Korten, Nicole C. M., Emsell, Louise, Eikelenboom, Piet, Rhebergen, Didi, Exel, Eric Van, and Dols, Annemieke

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy), 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental Material, Sociodemographic_apathy_scores_sites_2sep2019 for Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression? by Mardien Leoniek Oudega, Amna Siddiqui, Mike P. Wattjes, Frederik Barkhof, Mara ten Kate, Majon Muller, Filip Bouckaert, Mathieu Vandenbulcke, François-Laurent De Winter, Pascal Sienaert, Max L. Stek, Hannie C. Comijs, Nicole C. M. Korten, Louise Emsell, Piet Eikelenboom, Didi Rhebergen, Eric van Exel and Annemieke Dols in Journal of Geriatric Psychiatry and Neurology

Published
2020
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86. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

Author

Ousdal, Olga Therese, Argyelan, Miklos, Narr, Katherine L., Abbott, Christopher, Wade, Benjamin, Vandenbulcke, Mathieu, Urretavizcaya, Mikel, Tendolkar, Indira, Takamiya, Akihiro, Stek, Max L., Soriano-Mas, Carles, Redlich, Ronny, Paulson, Olaf B., Oudega, Mardien L., Opel, Nils, Nordanskog, Pia, Kishimoto, Taishiro, Kampe, Robin, Jørgensen, Anders, Hanson, Lars G., Hamilton, J. Paul, Espinoza, Randall, Emsell, Louise, van Eijndhoven, Philip, Dols, Annemieke, Dannlowski, Udo, Cardoner, Narcis, Bouckaert, Filip, Anand, Amit, Bartsch, Hauke, Kessler, Ute, Oedegaard, Ketil J., Dale, Anders M., Oltedal, Leif, Erchinger, Vera Jane, Haavik, Jan, Evjenth Sørhaug, Ole Johan, Jørgensen, Martin B., Bolwig, Tom G., Magnusson, Peter, Cano, Marta, Pujol, Jesús, Menchón, José M., Petrides, Georgios, Sienaert, Pascal, Ousdal, Olga Therese, Argyelan, Miklos, Narr, Katherine L., Abbott, Christopher, Wade, Benjamin, Vandenbulcke, Mathieu, Urretavizcaya, Mikel, Tendolkar, Indira, Takamiya, Akihiro, Stek, Max L., Soriano-Mas, Carles, Redlich, Ronny, Paulson, Olaf B., Oudega, Mardien L., Opel, Nils, Nordanskog, Pia, Kishimoto, Taishiro, Kampe, Robin, Jørgensen, Anders, Hanson, Lars G., Hamilton, J. Paul, Espinoza, Randall, Emsell, Louise, van Eijndhoven, Philip, Dols, Annemieke, Dannlowski, Udo, Cardoner, Narcis, Bouckaert, Filip, Anand, Amit, Bartsch, Hauke, Kessler, Ute, Oedegaard, Ketil J., Dale, Anders M., Oltedal, Leif, Erchinger, Vera Jane, Haavik, Jan, Evjenth Sørhaug, Ole Johan, Jørgensen, Martin B., Bolwig, Tom G., Magnusson, Peter, Cano, Marta, Pujol, Jesús, Menchón, José M., Petrides, Georgios, and Sienaert, Pascal

Abstract

Background: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. Methods: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. Results: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation ρ = −.44, p < .001), while total white matter volume remained unchanged (d = −0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. Conclusions: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.

Published
2020

88. A randomized controlled trial to evaluate the effectiveness and cost‐effectiveness of the FindMyApps intervention for improving self‐management and social participation of community‐dwelling people with dementia, compared to normal tablet use

Author

Neal, David Peter, primary, Kerkhof, Yvonne JF, additional, Ettema, Teake P, additional, Muller, Majon, additional, Bosmans, Judith, additional, Finnema, Evelyn, additional, Graff, Maud, additional, Tanja‐Dijkstra, Karin, additional, Stek, Max L, additional, and Droes, Rose‐Marie, additional

Published
2020
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91. 426 - FindMyApps: Protocol for a randomized controlled trial with community-dwelling people with dementia, evaluating the effectiveness and cost-effectiveness of an intervention to improve self-management and social participation

Author

Neal, David P., primary, Kerkhof, Yvonne J. F., additional, Ettema, Teake P., additional, Muller, Majon, additional, Bosmans, Judith, additional, Finnema, Evelyn, additional, Graff, Maud, additional, Tanja-Dijkstra, Karin, additional, Stek, Max L., additional, and Dröes, Rose-Marie, additional

Published
2020
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93. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

Author

Ousdal, Olga Therese, primary, Argyelan, Miklos, additional, Narr, Katherine L., additional, Abbott, Christopher, additional, Wade, Benjamin, additional, Vandenbulcke, Mathieu, additional, Urretavizcaya, Mikel, additional, Tendolkar, Indira, additional, Takamiya, Akihiro, additional, Stek, Max L., additional, Soriano-Mas, Carles, additional, Redlich, Ronny, additional, Paulson, Olaf B., additional, Oudega, Mardien L., additional, Opel, Nils, additional, Nordanskog, Pia, additional, Kishimoto, Taishiro, additional, Kampe, Robin, additional, Jorgensen, Anders, additional, Hanson, Lars G., additional, Hamilton, J. Paul, additional, Espinoza, Randall, additional, Emsell, Louise, additional, van Eijndhoven, Philip, additional, Dols, Annemieke, additional, Dannlowski, Udo, additional, Cardoner, Narcis, additional, Bouckaert, Filip, additional, Anand, Amit, additional, Bartsch, Hauke, additional, Kessler, Ute, additional, Oedegaard, Ketil J., additional, Dale, Anders M., additional, Oltedal, Leif, additional, Erchinger, Vera Jane, additional, Haavik, Jan, additional, Evjenth Sørhaug, Ole Johan, additional, Jørgensen, Martin B., additional, Bolwig, Tom G., additional, Magnusson, Peter, additional, Cano, Marta, additional, Pujol, Jesús, additional, Menchón, José M., additional, Petrides, Georgios, additional, and Sienaert, Pascal, additional

Published
2020
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94. Are Apathy and Depressive Symptoms Related to Vascular White Matter Hyperintensities in Severe Late Life Depression?

Author

Oudega, Mardien Leoniek, primary, Siddiqui, Amna, additional, Wattjes, Mike P., additional, Barkhof, Frederik, additional, Kate, Mara ten, additional, Muller, Majon, additional, Bouckaert, Filip, additional, Vandenbulcke, Mathieu, additional, De Winter, François-Laurent, additional, Sienaert, Pascal, additional, Stek, Max L., additional, Comijs, Hannie C., additional, Korten, Nicole C. M., additional, Emsell, Louise, additional, Eikelenboom, Piet, additional, Rhebergen, Didi, additional, van Exel, Eric, additional, and Dols, Annemieke, additional

Published
2020
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95. Early life involvement in C9orf72 repeat expansion carriers.

Author

Gossink, Flora, Dols, Annemiek, Stek, Max L., Scheltens, Philip, Nijmeijer, Bas, Hokke, Petra Cohn, Dijkstra, Anke, Van Ruissen, Fred, Aalfs, Cora, Pijnenburg, Yolande A. L., and Cohn Hokke, Petra

Abstract

Objectives: The chromosome 9 open reading frame 72 gene (C9orf72) hexanucleotide repeat expansion (C9orf72RE) is the most common genetic cause of behavioural variant frontotemporal dementia (bvFTD). Since the onset of the C9orf72RE-associated disease is sometimes hard to define, we hypothesise that C9orf72RE may cause a lifelong neuropsychiatric vulnerability. The first aim of our study was to explore lifelong behavioural and personality characteristics in C9orf72RE. Second, we aimed to describe distinctive characteristics of C9orf72RE during disease course.Methods: Out of 183 patients from the Amsterdam Dementia Cohort that underwent genetic testing between 2011 and 2018, 20 C9orf72RE bvFTD patients and 23 C9orf72RE negative bvFTD patients were included. Patients and their relatives were interviewed extensively to chart their biography. Data analysis was performed through a mixed-methods approach including qualitative and quantitative analyses.Results: Education, type of professional career and number of intimate partners were not different between carriers and non-carriers. Carriers were more often described by their relatives as having 'fixed behavioural patterns in daily life' and with limited empathy already years before onset of bvFTD symptoms. In carriers, disease course was more often characterised by excessive buying and obsessive physical exercise than in non-carriers.Conclusion: This is the first study thoroughly exploring biographies of bvFTD patients with C9orf72RE, revealing that subtle personality traits may be present early in life. Our study suggests that C9orf72RE exerts a lifelong neuropsychiatric vulnerability. This may strengthen hypotheses of links between neurodevelopmental and neurodegenerative diseases. Moreover, the presence of a distinct C9orf72RE -associated syndrome within the FTD spectrum opens doors for investigation of vulnerable neuronal networks. [ABSTRACT FROM AUTHOR]

Published
2022
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96. Loneliness, social network size, and mortality in older adults and the role of cortisol.

Author

Schutter, Natasja, Holwerda, Tjalling J., Comijs, Hannie C., Naarding, Paul, Van, Rien H.L., Dekker, Jack J.M., Stek, Max L., and Rhebergen, Didi

Subjects
LONELINESS in old age, SURVIVAL, SOCIAL networks, MORTALITY, CROSS-sectional method, MENTAL depression, DESCRIPTIVE statistics, HYDROCORTISONE
Abstract

Loneliness and social isolation have both been found to be associated with increased mortality in previous studies. One potential underlying mechanism is via the hypothalamic-pituitary-adrenal axis. This study aimed to examine the association between social network size and cortisol, to analyze the associations between both loneliness and social network size and mortality, and to examine to what extent the association between network size and/or loneliness and mortality is mediated by cortisol. The study group consisted of 443 depressed and non-depressed participants of the Netherlands Study of Depression in the Elderly (NESDO). Cross-sectional analysis of the association between social network size and cortisol measures was followed by a survival analysis of the associations between both social network size and loneliness and mortality. There were no significant associations between social network size and cortisol measures. Loneliness and small social network size were not associated with mortality. Age and partner status were more important predictors of mortality. As people grow older the variety of factors that influence mortality risk increases, diminishing the effect of a single factor. Prevention of early morbidity and mortality in older adults should be tailored to specific needs and risks, instead of aiming at one specific factor. [ABSTRACT FROM AUTHOR]

Published
2021
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