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52. Age-related changes in trabecular bone microstructures: global and local morphometry

Author

Stauber, M., Müller, R., Stauber, M., and Müller, R.

Abstract

Introduction: A recently developed method allows investigating trabecular bone on an elemental (rod/plate) level. With this method, it is possible to measure local morphometric parameters such as thickness or orientation directly on the extracted rods and plates. Age-related changes of trabecular microarchitecture can thus be investigated on an elemental level, which may help to improve the understanding of age-related bone failure mechanism as well as the effect of pharmaceutical intervention in the prevention of such fractures. Methods: Autopsies from femoral heads (FH) and lumbar spine (LS) were analyzed by global morphometry. Additionally, the trabecular structures were decomposed into rods and plates for the analysis with local morphometry. These morphometric indices were related to age using an analysis of covariance to test for gender differences and linearity with age. Results: In this study, age-related changes showed no gender but site differences. In LS, rods were thinned in aging and finally vanish from the structure, causing a transformation of the trabecular bone structure to longer and, on average, thicker rods. In FH, changes were expressed by a simultaneous thinning and loss of interconnecting trabeculae and perforation of plates leading to new plates and rods. Results were mostly in agreement with earlier findings using descriptive analysis of the aging process. Conclusion: Here we present for the first time preliminary quantitative evidence of changes in the local microstructure, i.e., individual rods and plates. Nevertheless, the number of samples was too small to make for ready conclusions. We conclude that the combination of local and global morphometry is a useful method for a detailed and quantitative description of age-related changes in bone microstructure

Published
2018

53. Thermoluminescent dosimetry for LDEF experiment M0006

Author

Chang, J. Y, Giangano, D, Kantorcik, T, Stauber, M, and Snead, L

Subjects
Space Radiation
Abstract

Experiment M0006 on the Long Duration Exposure Facility had as its objective the investigation of space radiation effects on various electronic and optical components, as well as on seed germination. The Grumman Corporate Research Center provided the radiation dosimetric measurements for M0006, comprising the preparation of thermoluminescent dosimeters (TLD) and the subsequent measurement and analysis of flight exposed and control samples. In addition, various laboratory exposures of TLD's with gamma rays and protons were performed to obtain a better understanding of the flight exposures.

Published
1992

54. A new method for using Cf-252 in SEU testing

Author

Costantine, A, Howard, J. W, Becker, M, Block, R. C, Smith, L. S, Soli, G. A, and Stauber, M. C

Subjects
Nuclear And High-Energy Physics
Abstract

A system using Cf-252 and associated nuclear instrumentation has determined the single-event upset (SEU) cross section versus linear energy transfer (LET) curve for several 2K x 8 static random access memories (SRAMs). The Cf-252 fission fragments pass through a thin-film organic scintillator detector (TFD) on the way to the device under test (DUT). The TFD provides energy information for each transiting fragment. Data analysis provides the energy of the individual ion responsible for each SEU; thus, separate upset cross sections can be developed for different energy and mass regions of the californium spectrum. This californium-based device is quite small and fits onto a bench top. It provides a convenient and inexpensive supplement or alternative to accelerator and high-altitude/space SEU testing.

Published
1990
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55. Improved laparoscopic fertility testing

Author

Stauber, M., Maassen, V., Stadler, C., Spielmann, H., Schwerdt, M., Dincer, C., Krueger, C., Radke, E., Hartwig, R., Harrison, Robert F., editor, Bonnar, John, editor, and Thompson, William, editor

Published
1984
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65. Paneldiskussion

Author

Bräutigam, W., Becker, S., Feurle, G. E., Franke, G., Klapp, B., Meerwein, F., Stauber, M., Theml, H., Wolf, G., and Bräutigam, Walter, editor

Published
1988
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78. Bottom-up Gold Filling of Trenches in Curved Wafers

Author

Josell, D., Raciti, D., Gnaupel-Herold, T., Pereira, A., Tsai, V., Yu, Q., Chen, L., Stauber, M., Rawlik, M., Stampanoni, M., Moffat, T. P., and Romano, L.

Abstract

A Bi3+-stimulated Au electrodeposition process in slightly alkaline Na3AuSO32+Na2SO3electrolytes has been previously demonstrated for void-free extreme bottom-up filling of high aspect ratio trenches in gratings that are key to advanced X-ray imaging technologies. Effective use of the full area of the gratings with conventional X-ray sources requires they have a finite radius of curvature to align the high aspect ratio Au-filled trenches with divergent X-rays. With that in mind, this work demonstrates bottom-up Au filling in gratings that are attached to curved holders. Contactless mapping of the Au-filled gratings captures residual curvature that is retained after their release from the curved holders (i.e., intrinsic curvature). X-ray diffraction captures the elastic strains in the Si underlying the Au-filled trenches of the grating. Complementary measurements on the surfaces of unpatterned Si wafers mounted on curved holders capture the actual curvatures and strains imposed in the mounted gratings. The gratings, either intrinsically curved or re-bent, provide high visibility across the entire field of view of an X-ray phase contrast imaging system with elastic strains substantially below those in planar gratings bent to the same radius.

Published
2024
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80. Einführung

Author

Stauber, M., Teichmann, Alexander T., editor, Dmoch, Walter, editor, and Stauber, Manfred, editor

Published
1989
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82. Allgemeines

Author

Neubüser, D., Schuster, R., Ludwig, O., Schewe, G., Tammi, C., Peters, J., Roemer, V. M., Peters, F. D., Drähne, A., Doch, S., König, S., Zubke, W., Schiefenhövel, W., Bartholomeyczik, E., Jaensch, E., Trull, U., Trull, H., Soiva, K., Gummerus, M., Woraschk, H. -J., Röpke, F., Kirchner, H., Karkut, G., Enders, I., Zubke, W., Dieckmann, W., O'Beirne, I., Drähne, A., Walter, Jr., H., Kunzel, W., Peters, F. D., Roemer, V. M., Neu-Brändle, W., Schneider, H., Prill, H. J., Stauber, M., Goldstein, M., and Meyenburg, M.

Published
1979
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85. Verschiedenes

Author

Silló-Seidl, Georg, Winkhaus, I., Scholze, R., Steinbeck, H., Kaiser, R., Mickan, H., Rjosk, H. K., Eversmann, I., Zander, J., Broer, K. H., Winkhaus, I., Kaiser, R., Knabe, H., Schade, A., Hackelöer, B. -J., Nitschke, S., Daume, E., Sturm, G., Buchholz, R., Meyenburg, M., Krajnović, P., Smiljanić, N., Gašparac, B., Bernoth, E., Link, M., Weise, W., Donat, H., Kapitza, W., stauber, M., stadler, C., Hardt, W., Maaßen, W., Farkas, G., Silló-Seidl, G., Berendes, R., Winkhaus, I., Bolte, A., Propping, D., Tauber, P. F., Katzorke, Th., Lübke, F., Schmidt-Elmendorff, H., Steyer, M., Steuber, H. G., Broer, K. H., Kaiser, R., Krebs, D., Springer, N., Lehmann, F., Hackelöer, B. -J., Robinson, H. P., Baranyai, E., Váradi, I., Keller, E., Zubke, W., Göser, R., and Schindler, A. E.

Published
1979
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88. Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice

Author

Mirsaidi, A, Kleinhans, K N, Rimann, M, Tiaden, A N, Stauber, M, Rudolph, K L, Richards, P J, University of Zurich, and Richards, P J

Subjects
Biomaterials, 11077 Center for Applied Biotechnology and Molecular Medicine, 10076 Center for Integrative Human Physiology, 2502 Biomaterials, Biomedical Engineering, 570 Life sciences, biology, 2204 Biomedical Engineering, Medicine (miscellaneous), 610 Medicine & health, 2701 Medicine (miscellaneous), 10090 Equine Department
Published
2012
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89. Über inhumane Praktiken der Frauenheilkunde im Nationalsozialismus und ihre Opfer

Author

Kindermann G and Stauber M

Subjects
media_common.quotation_subject, Obstetrics and Gynecology, Shame, Regret, Nazism, Context (language use), language.human_language, German, Law, Political science, Maternity and Midwifery, language, Nazi Germany, Conscience, media_common, Criminal negligence
Abstract

In our opinion German gynaecology has failed to adequately face what came to pass during the Nazi period. This can be proved objectively, for there is no evidence that, after 1945, gynaecology had in any way cared to take notice--either thermatically or medically--of the thousands of victims of inhuman practices such as forced termination of pregnancy, compulsory sterilisation and the like. During the past 50 years recollections of enforced sterilisations, compulsory abortions, deliberate and hence criminal negligence and problematic approaches in research and teaching were almost completely banished from the area of conscious awareness and largely suppressed or silently ignored. Most of the medical directors of Departments of Gynaecology of German universities shared this view whenever they were questioned on the connections between gynaecology and Nazism. Now that two generations have passed it seems possible to examine and explore with less guilt feelings and shame the immensely fateful role of gynaecology in that context. Accent should be on the fate of the victims of that period. To bring back these events to memory, however, does not permit to conceal the part played by the physicians committing of these inhuman Nazi crimes. Data collected from a psychosomatically oriented examination of victims exemplify that to concretely recall gynaecology during Nazism a1-so offers a chance in several respects. One of the possibilities in this context is to signal "late apology" and regret to patients who had been victims, in one's own area of work, after one has psychically worked over their fate. Besides, a gynaecological-psychosomatic expertise will help e.g. that compulsorily sterilised women are granted financial aid that has at long last become a legal possibility and can be applied for since 1980. However, the relevant patient records do show very clearly that the inhuman practice of gynaecology during the so-called "Third Reich" was not only a collective problem but equally due to a failure of the individual conscience of numerous gynaecologists. Working over this complex may enhance our own sensitivity for psychosomatic and ethic problems and counteract any likelihood of a recurrence of an inhuman gynaecology.

Published
1994
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93. Effects of muCT radiation on tissue engineered bone-like constructs

Author

Kraehenbuehl, T P, Stauber, M, Ehrbar, M, Weber, Franz E, Hall, H, Müller, R, University of Zurich, and Müller, R

Subjects
10022 Division of Surgical Research, 2204 Biomedical Engineering, 610 Medicine & health, 10069 Clinic of Cranio-Maxillofacial Surgery, 10026 Clinic for Obstetrics
Published
2010

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