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51. Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy

Author

Schaub, Friederike, primary, Schiller, Petra, additional, Hoerster, Robert, additional, Kraus, Daria, additional, Holz, Frank G., additional, Guthoff, Rainer, additional, Agostini, Hansjürgen, additional, Spitzer, Martin S., additional, Wiedemann, Peter, additional, Lommatzsch, Albrecht, additional, Boden, Karl T., additional, Dimopoulos, Spyridon, additional, Bemme, Sebastian, additional, Tamm, Svenja, additional, Maier, Mathias, additional, Roider, Johann, additional, Enders, Philip, additional, Altay, Lebriz, additional, Fauser, Sascha, additional, Kirchhof, Bernd, additional, Pfeiffer, Andrea, additional, Willms, Sandra, additional, Binder, Susanne, additional, Le Mer, Yannik, additional, Stützer, Hartmut, additional, Lemmen, Klaus-Dieter, additional, Heimke-Brinck, Ralph, additional, Borst, Tobias, additional, Bartz-Schmidt, Karl Ulrich, additional, Callizo, Josep, additional, Dahlke, Claudia, additional, Eberwein, Philipp, additional, Ehlken, Christoph, additional, Feltgen, Nicolas, additional, Gamulescu, Andreea, additional, Gelisken, Faik, additional, Gutfleisch, Matthias, additional, Haus, Arno, additional, Helbig, Horst, additional, Hermann, Manuel, additional, Januschowski, Kai, additional, Jochmann, Claudia, additional, Krohne, Tim, additional, Lagrèze, Wolf, additional, Lange, Clemens, additional, Lohmann, Chris, additional, Macek, Marc Andrej, additional, Märker, David, additional, Mayer, Christian, additional, Meier, Petra, additional, Müther, Philipp, additional, Prahs, Philipp, additional, Purtskhvanidze, Konstantine, additional, Rehak, Matus, additional, Schaub, Friederike, additional, Schick, Tina, additional, Schmitz-Valckenberg, Steffen, additional, Schultheiß, Maximilian, additional, Skevas, Christos, additional, Stahl, Andreas, additional, Szurman, Peter, additional, Unterlauft, Jan Darius, additional, Hellmich, Martin, additional, and Kuhr, Katrin, additional

Published
2022
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52. Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

Author

Feltgen, Nicolas, primary, Ach, Thomas, additional, Ziemssen, Focke, additional, Quante, Carolin Sophie, additional, Gross, Oliver, additional, Abdin, Alaa Din, additional, Aisenbrey, Sabine, additional, Bartram, Martin C., additional, Blum, Marcus, additional, Brockmann, Claudia, additional, Dithmar, Stefan, additional, Friedrichs, Wilko, additional, Guthoff, Rainer, additional, Hattenbach, Lars-Olof, additional, Herrlinger, Klaus R., additional, Kaskel-Paul, Susanne, additional, Khoramnia, Ramin, additional, Klaas, Julian E., additional, Krohne, Tim U., additional, Lommatzsch, Albrecht, additional, Lueken, Sabine, additional, Maier, Mathias, additional, Nassri, Lina, additional, Nguyen-Dang, Thien A., additional, Radeck, Viola, additional, Rau, Saskia, additional, Roider, Johann, additional, Sandner, Dirk, additional, Schmalenberger, Laura, additional, Schmidtmann, Irene, additional, Schubert, Florian, additional, Siegel, Helena, additional, Spitzer, Martin S., additional, Stahl, Andreas, additional, Stingl, Julia V., additional, Treumer, Felix, additional, Viestenz, Arne, additional, Wachtlin, Joachim, additional, Wolf, Armin, additional, Zimmermann, Julian, additional, Schargus, Marc, additional, and Schuster, Alexander K., additional

Published
2022
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58. Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy Results from a Randomized Clinical Trial

Author

Schaub, Friederike, Schiller, Petra, Hoerster, Robert, Kraus, Daria, Holz, Frank G., Guthoff, Rainer, Agostini, Hansjurgen, Spitzer, Martin S., Wiedemann, Peter, Lommatzsch, Albrecht, Boden, Karl T., Dimopoulos, Spyridon, Bemme, Sebastian, Tamm, Svenja, Maier, Mathias, Roider, Johann, Enders, Philip, Altay, Lebriz, Fauser, Sascha, Kirchhof, Bernd, Schaub, Friederike, Schiller, Petra, Hoerster, Robert, Kraus, Daria, Holz, Frank G., Guthoff, Rainer, Agostini, Hansjurgen, Spitzer, Martin S., Wiedemann, Peter, Lommatzsch, Albrecht, Boden, Karl T., Dimopoulos, Spyridon, Bemme, Sebastian, Tamm, Svenja, Maier, Mathias, Roider, Johann, Enders, Philip, Altay, Lebriz, Fauser, Sascha, and Kirchhof, Bernd

Abstract

Purpose: Proliferative vitreoretinopathy (PVR) is the major cause for surgical failure after primary rhegmatogenous retinal detachment (RRD). So far, no therapy has been proven to prevent PVR. Promising results for 5-fluorouracil (5-FU) and low-molecular weight heparin (LMWH) in high-risk eyes have been reported previously. The objective of this trial was to examine the effect of adjuvant intravitreal therapy with 5-FU and LMWH compared with placebo on incidence of PVR in high-risk patients with primary RRD. Design: Randomized, double-blind, controlled, multicenter, interventional trial with 1 interim analysis. Participants: Patients with RRD who were considered to be at high risk for PVR were included. Risk of PVR was assessed by noninvasive aqueous flare measurement using laser flare photometry. Methods: Patients were randomized 1:1 to verum (200 mg/ml 5-FU and 5 IU/ml dalteparin) and placebo (balanced salt solution) intravitreally applied during routine pars plana vitrectomy. Main Outcome Measures: Primary end point was the development of PVR grade CP (full-thickness retinal folds or subretinal strands in clock hours located posterior to equator) 1 or higher within 12 weeks after surgery. For grading, an end point committee assessed fundus photographs. Secondary end points included bestcorrected visual acuity and redetachment rate. A group sequential design with 1 interim analysis was applied using the O'Brien and Fleming boundaries. Proliferative vitreoretinopathy grade CP incidence was compared using a Mantel-Haenszel test stratified by surgeon. Results: A total of 325 patients in 13 German trial sites had been randomized (verum, n = 163; placebo, n = 162). In study eyes, mean laser flare was 31 +/- 26 pc/ms. No significant difference was found in PVR rate. Primary analysis in the modified intention-to-treat population results were: verum 28% vs. placebo 23% (including not assessable cases as failures); odds ratio [OR], 1.25; 95% confidence interval [CI], 0.76

Published
2022

65. The molecular hallmarks of primary and secondary vitreoretinal lymphoma

Author

Bonzheim, Irina, primary, Sander, Philip, additional, Salmeron-Villalobos, Julia, additional, Süsskind, Daniela, additional, Szurman, Peter, additional, Gekeler, Florian, additional, Spitzer, Martin S, additional, Steinhilber, Julia, additional, Kohler, Esther, additional, Büssgen, Melanie, additional, Schittenhelm, Jens, additional, Salaverria, Itziar, additional, Campo, Elias, additional, Coupland, Sarah E, additional, Quintanilla-Martinez, Leticia, additional, and Fend, Falko, additional

Published
2021
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76. sj-pdf-1-ejo-10.1177_11206721211014728 – Supplemental material for The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema

Author

Augustin, Albert J, Bopp, Silvia, Fechner, Martin, Holz, Frank G, Sandner, Dirk, Andrea-M Winkgen, Khoramnia, Ramin, Neuhann, Thomas, Warscher, Markus, Spitzer, Martin S, Sekundo, Walter, Seitz, Berthold, Duncker, Tobias, Ksinsik, Christian, and Höh, Helmut

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-1-ejo-10.1177_11206721211014728 for The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema by Albert J Augustin, Silvia Bopp, Martin Fechner, Frank G Holz, Dirk Sandner, Andrea-M Winkgen, Ramin Khoramnia, Thomas Neuhann, Markus Warscher, Martin S Spitzer, Walter Sekundo, Berthold Seitz, Tobias Duncker, Christian Ksinsik and Helmut Höh in European Journal of Ophthalmology

Published
2021
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77. sj-pdf-2-ejo-10.1177_11206721211014728 – Supplemental material for The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema

Author

Augustin, Albert J, Bopp, Silvia, Fechner, Martin, Holz, Frank G, Sandner, Dirk, Andrea-M Winkgen, Khoramnia, Ramin, Neuhann, Thomas, Warscher, Markus, Spitzer, Martin S, Sekundo, Walter, Seitz, Berthold, Duncker, Tobias, Ksinsik, Christian, and Höh, Helmut

Subjects
Medicine
Abstract

Supplemental material, sj-pdf-2-ejo-10.1177_11206721211014728 for The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema by Albert J Augustin, Silvia Bopp, Martin Fechner, Frank G Holz, Dirk Sandner, Andrea-M Winkgen, Ramin Khoramnia, Thomas Neuhann, Markus Warscher, Martin S Spitzer, Walter Sekundo, Berthold Seitz, Tobias Duncker, Christian Ksinsik and Helmut Höh in European Journal of Ophthalmology

Published
2021
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79. The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema

Author

Augustin, Albert J, primary, Bopp, Silvia, additional, Fechner, Martin, additional, Holz, Frank G, additional, Sandner, Dirk, additional, Winkgen, Andrea-M, additional, Khoramnia, Ramin, additional, Neuhann, Thomas, additional, Warscher, Markus, additional, Spitzer, Martin S, additional, Sekundo, Walter, additional, Seitz, Berthold, additional, Duncker, Tobias, additional, Ksinsik, Christian, additional, and Höh, Helmut, additional

Published
2021
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82. Rationale and Design of the Hamburg City Health Study

Author

Jagodzinski, Annika, Johansen, Christoffer, Koch‑Gromus, Uwe, Aarabi, Ghazal, Adam, Gerhard, Anders, Sven, Augustin, Matthias, der Kellen, Ramona B., Beikler, Thomas, Behrendt, Christian-Alexander, Betz, Christian S., Bokemeyer, Carsten, Borof, Katrin, Briken, Peer, Busch, Chia-Jung, Büchel, Christian, Brassen, Stefanie, Debus, Eike S., Eggers, Larissa, Fiehler, Jens, Gallinat, Jürgen, Gellißen, Simone, Gerloff, Christian, Girdauskas, Evaldas, Gosau, Martin, Graefen, Markus, Härter, Martin, Harth, Volker, Heidemann, Christoph, Heydecke, Guido, Huber, Tobias B., Hussein, Yassin, Kampf, Marvin O., von dem Knesebeck, Olaf, Konnopka, Alexander, König, Hans-Helmut, Kromer, Robert, Kubisch, Christian, Kühn, Simone, Loges, Sonja, Löwe, Bernd, Lund, Gunnar, Meyer, Christian, Nagel, Lina, Nienhaus, Albert, Pantel, Klaus, Petersen, Elina, Püschel, Klaus, Reichenspurner, Hermann, Sauter, Guido, Scherer, Martin, Scherschel, Katharina, Schiffner, Ulrich, Schnabel, Renate B., Schulz, Holger, Smeets, Ralf, Sokalskis, Vladislavs, Spitzer, Martin S., Terschüren, Claudia, Thederan, Imke, Thoma, Tom, Thomalla, Götz, Waschki, Benjamin, Wegscheider, Karl, Wenzel, Jan-Per, Wiese, Susanne, Zyriax, Birgit-Christiane, Zeller, Tanja, Blankenberg, Stefan, Jagodzinski, Annika, Johansen, Christoffer, Koch‑Gromus, Uwe, Aarabi, Ghazal, Adam, Gerhard, Anders, Sven, Augustin, Matthias, der Kellen, Ramona B., Beikler, Thomas, Behrendt, Christian-Alexander, Betz, Christian S., Bokemeyer, Carsten, Borof, Katrin, Briken, Peer, Busch, Chia-Jung, Büchel, Christian, Brassen, Stefanie, Debus, Eike S., Eggers, Larissa, Fiehler, Jens, Gallinat, Jürgen, Gellißen, Simone, Gerloff, Christian, Girdauskas, Evaldas, Gosau, Martin, Graefen, Markus, Härter, Martin, Harth, Volker, Heidemann, Christoph, Heydecke, Guido, Huber, Tobias B., Hussein, Yassin, Kampf, Marvin O., von dem Knesebeck, Olaf, Konnopka, Alexander, König, Hans-Helmut, Kromer, Robert, Kubisch, Christian, Kühn, Simone, Loges, Sonja, Löwe, Bernd, Lund, Gunnar, Meyer, Christian, Nagel, Lina, Nienhaus, Albert, Pantel, Klaus, Petersen, Elina, Püschel, Klaus, Reichenspurner, Hermann, Sauter, Guido, Scherer, Martin, Scherschel, Katharina, Schiffner, Ulrich, Schnabel, Renate B., Schulz, Holger, Smeets, Ralf, Sokalskis, Vladislavs, Spitzer, Martin S., Terschüren, Claudia, Thederan, Imke, Thoma, Tom, Thomalla, Götz, Waschki, Benjamin, Wegscheider, Karl, Wenzel, Jan-Per, Wiese, Susanne, Zyriax, Birgit-Christiane, Zeller, Tanja, and Blankenberg, Stefan

Abstract

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long

Published
2021

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