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51. Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice.

Author

Fogelgren, Ben, Kuroyama, Mari C., McBratney-Owen, Brandeis, Spence, Allyson A., Malahn, Laura E., Anawati, Mireille K., Cabatbat, Chantelle, Alarcon, Vernadeth B., Marikawa, Yusuke, and Lozanoff, Scott

Abstract

A radiation-induced mouse mutant, Brachyrrhine ( Br), exhibits frontonasal dysplasia and renal hypoplasia, two malformations associated with deficiencies in mesenchymal condensation. The purpose of this study was to resolve the Br locus, evaluate possible candidate genes, and identify developmental defects in the mutant chondrocranium. Linkage analysis mapped the Br mutation to a critical region distal to D17Mit76, which contains only one gene, the transcription factor Six2. Sequence analysis of the Six2 gene, including 1.5 kb of the promoter, failed to reveal the Br mutation. However, homozygous Br/ Br embryos showed almost complete absence of Six2 mRNA and protein in craniofacial and renal tissues while heterozygous Br/+ embryos displayed intermediate Six2 levels. Mutant embryos displayed malformations of neural crest-derived structures of the anterior cranium where Six2 is normally expressed. These data suggest a mutation in a novel cis-acting regulatory region inhibits Six2 expression and is associated with frontonasal dysplasia and renal hypoplasia. Developmental Dynamics 237:1767-1779, 2008. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2008
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55. Correction for Spence et al., Revealing the specificity of regulatory T cells in murine autoimmune diabetes.

Author

Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, Tang, Qizhi, Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, and Tang, Qizhi

56. Navigating Familial Opioid Use Addictions and Socially Complex Situations in the Treatment of Acute and Chronic Inpatient Pain

Author

Jotwani, Rohan, Hankins, David, Prabhakar, Amit, Turpin, Michelle, Novitch, Matthew, Spence, Allyson, Juneau, Andrea, Okereke, Eva, Patil, Shilpa, Cornett, Elyse, Kaye, Alan, Avery, Jonathan, Mehta, Neel, Jotwani, Rohan, Hankins, David, Prabhakar, Amit, Turpin, Michelle, Novitch, Matthew, Spence, Allyson, Juneau, Andrea, Okereke, Eva, Patil, Shilpa, Cornett, Elyse, Kaye, Alan, Avery, Jonathan, and Mehta, Neel

57. Revealing the specificity of regulatory T cells in murine autoimmune diabetes

Author

Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, Tang, Qizhi, Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, and Tang, Qizhi

58. The role of regional anesthesia in the propagation of cancer: A comprehensive review.

Author

Sen, Sudipta, Koyyalamudi, Veerandra, Smith, Darwin, Weis, Ricardo, Molloy, Michael, Spence, Allyson, Kaye, Aaron, Labrie-Brown, Carmen, Hall, O., Cornett, Elyse, Kaye, Alan, Sen, Sudipta, Koyyalamudi, Veerandra, Smith, Darwin, Weis, Ricardo, Molloy, Michael, Spence, Allyson, Kaye, Aaron, Labrie-Brown, Carmen, Hall, O., Cornett, Elyse, and Kaye, Alan

59. Commonly Prescribed Medications that Affect Clotting: A Comprehensive Overview

Author

Shelvan, Anitha, Spence, Allyson, Parsiola, Anne, Anandi, Prathima, Siddaiah, Harish, Latimer, Dustin, Saus, J., Prabhakar, Amit, Core, Daniel, Cornett, Elyse, Kaye, Alan, Shelvan, Anitha, Spence, Allyson, Parsiola, Anne, Anandi, Prathima, Siddaiah, Harish, Latimer, Dustin, Saus, J., Prabhakar, Amit, Core, Daniel, Cornett, Elyse, and Kaye, Alan

64. Impact of COVID-19 infection on the cardiovascular system: An evidence-based analysis of risk factors and outcomes

Author

Kaye, Alan D., Spence, Allyson L., Mayerle, Mariah, Sardana, Nitish, Clay, Claire M., Eng, Matthew R., Luedi, Markus M., Carroll Turpin, Michelle A., Urman, Richard D., Cornett, Elyse M., Kaye, Alan D., Spence, Allyson L., Mayerle, Mariah, Sardana, Nitish, Clay, Claire M., Eng, Matthew R., Luedi, Markus M., Carroll Turpin, Michelle A., Urman, Richard D., and Cornett, Elyse M.

71. Commonly Prescribed Medications that Affect Clotting: A Comprehensive Overview

Author

Shelvan, Anitha, Spence, Allyson, Parsiola, Anne, Anandi, Prathima, Siddaiah, Harish, Latimer, Dustin, Saus, J., Prabhakar, Amit, Core, Daniel, Cornett, Elyse, Kaye, Alan, Shelvan, Anitha, Spence, Allyson, Parsiola, Anne, Anandi, Prathima, Siddaiah, Harish, Latimer, Dustin, Saus, J., Prabhakar, Amit, Core, Daniel, Cornett, Elyse, and Kaye, Alan

72. Correction for Spence et al., Revealing the specificity of regulatory T cells in murine autoimmune diabetes.

Author

Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, Tang, Qizhi, Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, and Tang, Qizhi

73. Navigating Familial Opioid Use Addictions and Socially Complex Situations in the Treatment of Acute and Chronic Inpatient Pain

Author

Jotwani, Rohan, Hankins, David, Prabhakar, Amit, Turpin, Michelle, Novitch, Matthew, Spence, Allyson, Juneau, Andrea, Okereke, Eva, Patil, Shilpa, Cornett, Elyse, Kaye, Alan, Avery, Jonathan, Mehta, Neel, Jotwani, Rohan, Hankins, David, Prabhakar, Amit, Turpin, Michelle, Novitch, Matthew, Spence, Allyson, Juneau, Andrea, Okereke, Eva, Patil, Shilpa, Cornett, Elyse, Kaye, Alan, Avery, Jonathan, and Mehta, Neel

75. Revealing the specificity of regulatory T cells in murine autoimmune diabetes

Author

Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, Tang, Qizhi, Spence, Allyson, Purtha, Whitney, Tam, Janice, Dong, Shen, Kim, Youmin, Ju, Chia-Hsin, Sterling, Teague, Nakayama, Maki, Robinson, William, Bluestone, Jeffrey, Anderson, Mark, and Tang, Qizhi

76. The role of regional anesthesia in the propagation of cancer: A comprehensive review.

Author

Sen, Sudipta, Koyyalamudi, Veerandra, Smith, Darwin, Weis, Ricardo, Molloy, Michael, Spence, Allyson, Kaye, Aaron, Labrie-Brown, Carmen, Hall, O., Cornett, Elyse, Kaye, Alan, Sen, Sudipta, Koyyalamudi, Veerandra, Smith, Darwin, Weis, Ricardo, Molloy, Michael, Spence, Allyson, Kaye, Aaron, Labrie-Brown, Carmen, Hall, O., Cornett, Elyse, and Kaye, Alan

82. Impact of COVID-19 infection on the cardiovascular system: An evidence-based analysis of risk factors and outcomes

Author

Kaye, Alan D., Spence, Allyson L., Mayerle, Mariah, Sardana, Nitish, Clay, Claire M., Eng, Matthew R., Luedi, Markus M., Carroll Turpin, Michelle A., Urman, Richard D., Cornett, Elyse M., Kaye, Alan D., Spence, Allyson L., Mayerle, Mariah, Sardana, Nitish, Clay, Claire M., Eng, Matthew R., Luedi, Markus M., Carroll Turpin, Michelle A., Urman, Richard D., and Cornett, Elyse M.

85. Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.

Author

Klementowicz, Joanna E., Mahne, Ashley E., Spence, Allyson, Nguyen, Vinh, Satpathy, Ansuman T., Murphy, Kenneth M., and Qizhi Tang

Subjects
*AUTOIMMUNE diseases, *IMMUNOLOGIC diseases, *CHEMOKINES, *CHEMOKINE genetics, *CHEMOTACTIC factors, *THERAPEUTICS
Abstract

In NOD mice, CD11c+ cells increase greatly with islet inflammation and contribute to autoimmune destruction of pancreatic β cells. In this study, we investigated their origin and mechanism of recruitment. CD11c+ cells in inflamed islets resembled classical dendritic cells based on their transcriptional profile. However, the majority of these cells were not from the Zbtb46-dependent dendritic-cell lineage. Instead, monocyte precursors could give rise to CD11c+ cells in inflamed islets. Chemokines Ccl5 and Ccl8 were persistently elevated in inflamed islets and the influx of CD11c+ cells was partially dependent on their receptor Ccr5. Treatment with islet Agspecific regulatory T cells led to a marked decrease of Ccl5 and Ccl8, and a reduction of monocyte recruitment. These results implicate a monocytic origin of CD11c+ cells in inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering the chemotactic milieu in the islets. [ABSTRACT FROM AUTHOR]

Published
2017
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