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706 results on '"Spampinato S."'

55. Immunomodulatory role of Nociceptin/Orphanin FQ-NOP receptor system in a rat model of experimental colitis

Author

Petrella, C., Giuli, C., Eutamène, Hélène, Cartier, Christel, Lévêque, Mathilde, Bedini, A., Spampinato, S., Bueno, Lionel, Theodorou, Vassilia, Broccardo, M., Agostini, Simona, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Neuro-Gastroentérologie & Nutrition (ToxAlim-NGN), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Endocrinologie & Toxicologie de la Barrière Intestinale (ToxAlim-ENTeRisk), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

88. Vas deferens response to selective opioid receptor agonists in adult mice is impaired following postnatal repeated mild stress

Author

Loizzo A., Capasso A., Galietta G., Severini C., Campana G., and Spampinato S.

Abstract

Mild stress repeatedly applied to neonatal rodents induces alterations of central nervous system functions, persisting up to the adult age. Most alterations may be mediated through hormones and neuromediators active on the autonomic nervous system, therefore we tested the efficacy of selective opioid receptor agonists on the vas deferens of adult mice that, as neonates, had undergone daily mild stress until weaning (brief isolation and solvent injection). We found in the adult mouse (90 days old) decreased sensitivity of vas deferens to selective mu-, delta- and kappa-opioid receptor agonist drugs. The neonatal administration of an antisense oligodeoxynucleotide adrenocorticotropin-synthesis-inhibitor partly prevented these effects.

Published
2003

94. Naloxone prevents cell-mediated immune alterations in adult mice following repeated mild stress in the neonatal period

Author

Loizzo, A., Loizzo, S., Lopez, L., D Amore, A., Renzi, P., Spampinato, S., Di Carlo, S., Bacosi, A., Zuccaro, P., and Pacifici, R.

Subjects
Leptin, Male, Pain Threshold, Naloxone, Narcotic Antagonists, Body Weight, Mice, Inbred Strains, Th1 Cells, Mice, Animals, Newborn, Stress, Physiological, Papers, Animals, Cytokines, Spleen
Abstract

1. Mild stress plus mild pain (solvent injection) applied daily to neonatal mice induces hormonal, behavioural and metabolic changes perduring in the adult life. 2. We investigated whether daily mild stress to neonatal mice induces also long-term defined changes of immune response, and whether immune changes are prevented through repeated administration of the opioid antagonist naloxone. 3. Mild stress plus solvent injection administered from birth to the 21st postnatal day causes not only behavioural and metabolic changes, but also long-term (up to 110 days of life) splenocytes modifications, consisting in: increased release of the Th-1 type cytokines interleukin-2 (IL-2) (from an average of 346 to 788 pg ml(-1)), interferon-gamma (from 1770 to 3942) and tumour necrosis factor-alpha (from 760 to 1241); decreased release of the Th-2 type cytokines IL-4 (from 49.1 to 28.4) and IL-10 (from 1508 to 877). Moreover, enhanced natural killer-cell activity; enhanced proliferative splenocytes properties in resting conditions and following phytohemoagglutinin and concanavalin-A stimulation are observed. Immunological, behavioural and metabolic changes are prevented by the opioid antagonist (-)naloxone (1 mg kg(-1) per day s.c., administered instead of solvent) but not by the biologically inactive enantiomorph (+)naloxone. 4. In conclusion, endogenous opioid systems sensitive to naloxone are involved in long-lasting enhancement of the Th-1 type cytokines and cell-mediated immunological response caused by repeated mild stress administered postnatally.

Published
2002

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