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52. Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach

Author

Petrosyan, Varduhi, Dobrolecki, Lacey E., Thistlethwaite, Lillian, Lewis, Alaina N., Sallas, Christina, Srinivasan, Ramakrishnan R., Lei, Jonathan T., Kovacevic, Vladimir, Obradovic, Predrag, Ellis, Matthew J., Osborne, C. Kent, Rimawi, Mothaffar F., Pavlick, Anne, Shafaee, Maryam Nemati, Dowst, Heidi, Jain, Antrix, Saltzman, Alexander B., Malovannaya, Anna, Marangoni, Elisabetta, Welm, Alana L., Welm, Bryan E., Li, Shunqiang, Wulf, Gerburg M., Sonzogni, Olmo, Huang, Chen, Vasaikar, Suhas, Hilsenbeck, Susan G., Zhang, Bing, Milosavljevic, Aleksandar, and Lewis, Michael T.

Published
2023
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56. Characterization and performance of the DTAS detector

Author

Guadilla, V., Tain, J. L., Algora, A., Agramunt, J., Äystö, J., Briz, J. A., Cucoanes, A., Eronen, T., Estienne, M., Fallot, M., Fraile, L. M., Ganioğlu, E., Gelletly, W., Gorelov, D., Hakala, J., Jokinen, A., Jordan, D., Kankainen, A., Kolhinen, V., Koponen, J., Lebois, M., Meur, L. Le, Martinez, T., Monserrate, M., Montaner-Pizá, A., Moore, I., Nácher, E., Orrigo, S. E. A., Penttilä, H., Pohjalainen, I., Porta, A., Reinikainen, J., Reponen, M., Rice, S., Rinta-Antila, S., Rubio, B., Rytkönen, K., Shiba, T., Sonnenschein, V., Sonzogni, A. A., Valencia, E., Vedia, V., Voss, A., Wilson, J. N., and Zakari-Issoufou, A. -A.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

DTAS is a segmented total absorption {\gamma}-ray spectrometer developed for the DESPEC experiment at FAIR. It is composed of up to eighteen NaI(Tl) crystals. In this work we study the performance of this detector with laboratory sources and also under real experimental conditions. We present a procedure to reconstruct offline the sum of the energy deposited in all the crystals of the spectrometer, which is complicated by the effect of NaI(Tl) light-yield non-proportionality. The use of a system to correct for time variations of the gain in individual detector modules, based on a light pulse generator, is demonstrated. We describe also an event-based method to evaluate the summing-pileup electronic distortion in segmented spectrometers. All of this allows a careful characterization of the detector with Monte Carlo simulations that is needed to calculate the response function for the analysis of total absorption {\gamma}-ray spectroscopy data. Special attention was paid to the interaction of neutrons with the spectrometer, since they are a source of contamination in studies of \b{eta}-delayed neutron emitting nuclei.

Published
2018
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57. Neonates undergoing pyloric stenosis repair are at increased risk of difficult airway management: secondary analysis of the NEonate and Children audiT of Anaesthesia pRactice IN Europe

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Catherine, Amory, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau Cécile Magne, Caroline, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, Brière, François de la, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Izzo, Francesca, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Federico, Bilotta, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Bystrica, Banská, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela Pirtovšek, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, Serrano, Cristina González, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, García, Ernesto Martínez, Tormo de las Heras, Carolina, Montero, Pablo Troncoso, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Comas, Montserrat Suarez, Escribá, Francisco, Auli, Cristina, Pardo, Osvaldo Pérez, Biddle, Natalia Sierra, Castaño, Ceferina Suárez, Villalobos Rico, María Isabel, Muñoz, Susana Manrique, Martínez, Irene García, Estruch, Nuria Montferrer, Ortíz, Elena Vilardell, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet Wolfe, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano Scalia, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Engelhardt, Thomas, Hansen, Tom G., de Graaff, Jurgen C., and Virag, Katalin

Published
2022
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61. Influence of cellular models and individual factor in the biological response to head CT scan exams

Author

Clément Devic, Larry Bodgi, Laurène Sonzogni, Frank Pilleul, Hervé Ribot, Charlotte De Charry, François Le Moigne, Didier Paul, Fanny Carbillet, Mélodie Munier, and Nicolas Foray

Subjects
DNA breaks (double-stranded), Li-Fraumeni syndrome, Neurofibromatosis 1, Radiobiology, Tomography (x-ray computed), Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background While computed tomography (CT) exams are the major cause of medical exposure to ionising radiation, the radiation-induced risks must be documented. We investigated the impact of the cellular models and individual factor on the deoxyribonucleic acid double-strand breaks (DSB) recognition and repair in human skin fibroblasts and brain astrocytes exposed to current head CT scan conditions. Method Nine human primary fibroblasts and four human astrocyte cell lines with different levels of radiosensitivity/susceptibility were exposed to a standard head CT scan exam using adapted phantoms. Cells were exposed to a single-helical (37.4 mGy) and double-helical (37.4 mGy + 5 min + 37.4 mGy) examination. DSB signalling and repair was assessed through anti-γH2AX and anti-pATM immunofluorescence. Results Head CT scan induced a significant number of γH2AX and pATM foci. The kinetics of both biomarkers were found strongly dependent on the individual factor. Particularly, in cells from radiosensitive/susceptible patients, DSB may be significantly less recognised and/or repaired, whatever the CT scan exposure conditions. Similar conclusions were reached with astrocytes. Conclusions Our results highlight the importance of both individual and tissue factors in the recognition and repair of DSB after current head CT scan exams. Further investigations are needed to better define the radiosensitivity/susceptibility of individual humans.

Published
2022
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62. Influence of cellular models and individual factor in the biological response to chest CT scan exams

Author

Clément Devic, Larry Bodgi, Laurène Sonzogni, Frank Pilleul, Hervé Ribot, Charlotte De Charry, François Le Moigne, Didier Paul, Fanny Carbillet, Mélodie Munier, and Nicolas Foray

Subjects
DNA breaks (double-stranded), Genes (BRCA1/2), Li-Fraumeni syndrome, Neurofibromatosis 1, Radiobiology, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background While computed tomography (CT) exams are the major cause of medical exposure to ionising radiation, there is increasing evidence that the potential radiation-induced risks must be documented. We investigated the impact of cellular models and individual factor on the deoxyribonucleic acid double-strand breaks (DSB) recognition and repair in human fibroblasts and mammary epithelial cells exposed to current chest CT scan conditions. Method Twelve human primary fibroblasts and four primary human mammary epithelial cell lines with different levels of radiosensitivity/susceptibility were exposed to a standard chest CT scan exam using adapted phantoms. Cells were exposed to a single helical irradiation (14.4 mGy) or to a topogram followed, after 1 min, by one single helical examination (1.1 mGy + 14.4 mGy). DSB signalling and repair was assessed through anti-γH2AX and anti-pATM immunofluorescence. Results Chest CT scan induced a significant number of γH2AX and pATM foci. The kinetics of both biomarkers were found strongly dependent on the individual factor. The topogram may also influence the biological response of radiosensitive/susceptible fibroblasts to irradiation. Altogether, our findings show that a chest CT scan exam may result in 2 to 3 times more unrepaired DSB in cells from radiosensitive/susceptible patients. Conclusions Both individual and tissue factors in the recognition and repair of DSB after current CT scan exams are important. Further investigations are needed to better define the radiosensitivity/susceptibility of individual humans.

Published
2022
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64. Revealing Fine Structure in the Antineutrino Spectra From a Nuclear Reactor

Author

Sonzogni, A. A., Nino, M., and McCutchan, E. A.

Subjects
Nuclear Theory, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

We calculate the Inverse Beta Decay (IBD) antineutrino spectrum generated by nuclear reactors using the summation method to understand deviations from the smooth Huber-Mueller model due to the decay of individual fission products, showing that plotting the ratio of two adjacent spectra points can effectively reveal these deviations. We obtained that for binning energies of 0.1 MeV or lower, abrupt changes in the spectra due to the jagged nature of the individual antineutrino spectra could be observed for highly precise experiments. Surprisingly, our calculations also reveal a peak-like feature in the adjacent points ratio plot at 4.5 MeV even with a 0.25 MeV binning interval, which we find is present in the IBD Daya Bay spectrum published in 2016. We show that this 4.5 MeV feature is caused by the contributions of just four fission products, 95Y, 98,101N and 102Tc. This would be the first evidence of the decay of a few fission products in the IBD antineutrino spectrum from a nuclear reactor., Comment: 5 pages, 6 figures

Published
2017
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65. Analysis of the Daya Bay Reactor Antineutrino Flux Changes with Fuel Burnup

Author

Hayes, Anna, Jungman, Gerard, McCutchan, Libby, Sonzogni, Alejandro, Garvey, Gerry, and Wang, Xiaobao

Subjects
Nuclear Theory, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

We investigate the recent Daya Bay results on the changes in the antineutrino flux and spectrum with the burnup of the reactor fuel. We find that the discrepancy between current model predictions and the Daya Bay results can be traced to the original measured $^{235}$U/$^{239}$Pu ratio of the fission beta spectra that were used as a base for the expected antineutrino fluxes. An analysis of the antineutrino spectra that is based on a summation over all fission fragment beta-decays, using nuclear database input, explains all of the features seen in the Daya Bay evolution data. However, this summation method still predicts an anomaly. Thus, we conclude that there is currently not enough information to use the antineutrino flux changes to rule out the possible existence of sterile neutrinos.

Published
2017
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66. White Paper on Nuclear Data Needs and Capabilities for Basic Science

Author

Kondev, F. G., Thoennessen, M., Batchelder, J., Kawano, T., Kelley, J., McCutchan, E., Smith, M., Sonzogni, A., and Thompson, I.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The Workshop on Nuclear Data Needs and Capabilities for Basic Science was held at the University of Notre Dame on 10-11 August 2016. The purpose of this targeted workshop was to assemble and prioritize the needs of the nuclear physics research community for data sets, services and capabilities in areas including nuclear structure, nuclear reactions, nuclear astrophysics, fundamental interactions, neutrino physics and nuclear theory. An overview of nuclear data needs and capabilities identified at this meeting are summarized in the present document., Comment: This white paper and copies of the presentations can be found on the meeting website at http://meetings.nscl.msu.edu/2016ND_workshop/html/home.html

Published
2017

67. Total Absorption Spectroscopy Study of the Beta Decay of $^{86}$Br and $^{91}$Rb

Author

Rice, S., Algora, A., Tain, J. L., Valencia, E., Agramunt, J., Rubio, B., Gelletly, W., Regan, P. H., Zakari-Issoufou, A. -A., Fallot, M., Porta, A., Rissanen, J., Eronen, T., Äystö, J., Batist, L., Bowry, M., Bui, V. M., Caballero-Folch, R., Cano-Ott, D., Elomaa, V. -V., Estevez, E., Farrelly, G. F., Garcia, A. R., Gomez-Hornillos, B., Gorlychev, V., Hakala, J., Jordan, M. D., Jokinen, A., Kondev, F. G., Martínez, T., Mason, P., Mendoza, E., Moore, I., Penttilä, H., Podolyák, Zs., Reponen, M., Sonnenschein, V., Sonzogni, A. A., and Sarriguren, P.

Subjects
Nuclear Experiment
Abstract

The beta decays of $^{86}$Br and $^{91}$Rb have been studied using the total absorption spectroscopy technique. The radioactive nuclei were produced at the IGISOL facility in Jyv\"askyl\"a and further purified using the JYFLTRAP. $^{86}$Br and $^{91}$Rb are considered to be major contributors to the decay heat in reactors. In addition $^{91}$Rb was used as a normalization point in direct measurements of mean gamma energies released in the beta decay of fission products by Rudstam {\it et al.} assuming that this decay was well known from high-resolution measurements. Our results show that both decays were suffering from the {\it Pandemonium} effect and that the results of Rudstam {\it et al.} should be renormalized. The relative impact of the studied decays in the prediction of the decay heat and antineutrino spectrum from reactors has been evaluated., Comment: 11 pages, 13 figures

Published
2017
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68. Study of the $\beta$-decay of $^{100}$Tc with Total Absorption $\gamma$-Ray Spectroscopy

Author

Guadilla, V., Algora, A., Tain, J. L., Agramunt, J., Jordan, D., Montaner-Pizá, A., Orrigo, S. E. A., Rubio, B., Valencia, E., Suhonen, J., Civitarese, O., Äystö, J., Briz, J. A., Cucoanes, A., Eronen, T., Estienne, M., Fallot, M., Fraile, L. M., Ganioglu, E., Gelletly, W., Gorelov, D., Hakala, J., Jokinen, A., Kankainen, A., Kolhinen, V., Koponen, J., Lebois, M., Martinez, T., Monserrate, M., Moore, I., Nácher, E., Penttilä, H., Pohjalainen, I., Porta, A., Reinikainen, J., Reponen, M., Rinta-Antila, S., Rytkönen, K., Shiba, T., Sonnenschein, V., Sonzogni, A. A., Vedia, V., Voss, A., Wilson, J. N., and Zakari-Issoufou, A. -A.

Subjects
Nuclear Experiment
Abstract

The \b{eta}-decay of 100 Tc has been studied using the Total Absorption {\gamma}-Ray Spectroscopy technique at IGISOL. In this work the new DTAS spectrometer in coincidence with a cylindrical plastic \b{eta} detector has been employed. The \b{eta}-intensity to the ground state obtained from the analysis is in good agreement with previous high-resolution measurements. However, differences in the feeding to the first excited state as well as weak feeding to a new level at high excitation energy have been deduced from this experiment. Theoretical calculations performed in the quasiparticle random- phase approximation (QRPA) framework are also reported. Comparison of these calculations with our measurement serves as a benchmark for calculations of the double \b{eta}-decay of 100 Mo., Comment: submitted to Physical Review C

Published
2017
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69. Northwest Africa 5958: a weakly altered CM-related ungrouped chondrite, not a CI3

Author

Jacquet, Emmanuel, Barrat, Jean-Alix, Beck, Pierre, Caste, Florent, Gattacceca, Jérôme, Sonzogni, Corinne, and Gounelle, Matthieu

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Northwest Africa (NWA) 5958 is a carbonaceous chondrite found in Morocco in 2009. Preliminary chemical and isotopic data leading to its initial classification as C3.0 ungrouped have prompted us to conduct a multi-technique study of this meteorite and present a general description here. The petrography and chemistry of NWA 5958 is most similar to a CM chondrite, with a low degree of aqueous alteration, apparently under oxidizing conditions, and evidence of a second, limited alteration episode manifested by alteration fronts. The oxygen isotopic composition, with $\Delta^{17}$O = -4.3 $\permil$, is more 16O-rich than all CM chondrites, indicating, along with other compositional arguments, a separate parent body of origin. We suggest that NWA 5958 be reclassified as an ungrouped carbonaceous chondrite related to the CM group., Comment: 32 pages, 12 figures

Published
2017
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70. Maize Responses to High Night Temperature During Postflowering and Early Grain Filling: Effects on Yield Components, Kernel Growth and Dry Matter Allocation.

Author

Kettler, Belén Araceli, Carrera, Constanza Soledad, Nalli Sonzogni, Federico David, Andrade, Fernando Héctor, and Neiff, Nicolás

Subjects
GENITALIA, PLANT yields, GLOBAL warming, HIGH temperatures, HEAT treatment
Abstract

Warm night frequency has increased steadily in the last years across maize production regions, but high night temperature (HNT) effects on growth, grain yield and maize dry matter allocation (DMA) to different plant organs remain poorly understood. In this study, we aimed to (i) analyse the DMA among reproductive and vegetative organs, (ii) evaluate the individual kernel weight through its determinants, rate and duration of grain filling and (iii) quantify changes in grain yield per plant and its components due to HNT during the postflowering and early grain‐filling period. Field‐grown maize was subjected to HNT induced by shelters during a 15‐ or 30‐day period after silking, encompassing the postflowering period (HNT15) and extending the heating into early grain filling (HNT30), respectively. The HNT was applied from 1900 to 0700 h while control plots remained at ambient night temperature (ANT). Kernel number per plant was decreased under both temperature regimes (i.e., HNT15 and HNT30); however, significant reductions in grain yield were only observed under HNT30. The DMA during the heating period was differentially affected by the duration of heating. While DMA to the stem was likewise reduced by both heating treatments, the partition to the uppermost ear was only reduced under HNT30. Related to the lack of response to HNT treatments of the rate and duration of grain filling, the individual kernel weight was not reduced. The source‐sink ratio was not affected by HNT, meanwhile, the apparent reserve use was significantly reduced under HNT30. Our results demonstrate that the magnitude of HNT effects is subjected to the duration of the heating period, but also depends on the intensity of heating explored across seasons, especially for kernel number and grain yield. [ABSTRACT FROM AUTHOR]

Published
2024
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71. Prediction of Cancer Proneness under Influence of X-rays with Four DNA Mutability and/or Three Cellular Proliferation Assays.

Author

El Nachef, Laura, Bodgi, Larry, Estavoyer, Maxime, Buré, Simon, Jallas, Anne-Catherine, Granzotto, Adeline, Restier-Verlet, Juliette, Sonzogni, Laurène, Al-Choboq, Joëlle, Bourguignon, Michel, Pujo-Menjouet, Laurent, and Foray, Nicolas

Subjects
TUMOR risk factors, RISK assessment, PREDICTIVE tests, FLOW cytometry, RESEARCH funding, CELL proliferation, DNA, GENETIC risk score, FIBROBLASTS, X-rays, GENETIC mutation, BIOLOGICAL assay, GENETIC techniques
Abstract

Simple Summary: By hypothesizing that molecular hyper-recombination and cellular proliferation are among the major features of multi-factorial cancer proneness, by using skin fibroblasts derived from eight major cancer syndromes, a significant correlation was found between the hyper-recombination rate quantified by plasmid assay, proliferation capacity assessed by flow cytometry, and excess of relative cancer risk (ERR). The product of the hyper-recombination rate and capacity of proliferation described a linear function of ERR. Context: Although carcinogenesis is a multi-factorial process, the mutability and the capacity of cells to proliferate are among the major features of the cells that contribute together to the initiation and promotion steps of cancer formation. Particularly, mutability can be quantified by hyper-recombination rate assessed with specific plasmid assay, hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations frequency rate, or MRE11 nuclease activities. Cell proliferation can be assessed by flow cytometry by quantifying G2/M, G1 arrests, or global cellular evasion. Methods: All these assays were applied to skin untransformed fibroblasts derived from eight major cancer syndromes characterized by their excess of relative cancer risk (ERR). Results: Significant correlations with ERR were found between hyper-recombination assessed by the plasmid assay and G2/M arrest and described a third-degree polynomial ERR function and a sigmoidal ERR function, respectively. The product of the hyper-recombination rate and capacity of proliferation described a linear ERR function that permits one to better discriminate each cancer syndrome. Conclusions: Hyper-recombination and cell proliferation were found to obey differential equations that better highlight the intrinsic bases of cancer formation. Further investigations to verify their relevance for cancer proneness induced by exogenous agents are in progress. [ABSTRACT FROM AUTHOR]

Published
2024
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73. Changes in 'ordinary' life. Covid-19's effects on young students' mental and physical well-being

Author

Barbara Sonzogni, Gabriella D'Ambrosio, and Dario Germani

Subjects
behaviour, emergency, lifestyles, mental well-being, physical well-being, web-survey, Social sciences (General), H1-99
Abstract

The present paper builds on the topic of ‘disaster studies’, addressing the most crucial theoretical aspects of them: a) the purpose of studying «meaningful interactions» between the social system and the individuals and their actions; b) the conviction that, in cases of a pandemic or natural disasters, pain and tragedy can take on unequalled levels of emergency, generating powerful effects as relates to the rhythms of ‘ordinary’ life; c) the role of cognitive processes in conditioning daily life and determining individual predispositions towards the future. From this perspective, the research explores the results obtained from an online survey conducted in 2021 on all Sapienza’s students, who have spent an academic mobility period outside Italy or inside Rome. The analysis explores variations and influences of the cognitive-emotional dimension (beliefs, desires, opportunities) on the (intention-to-) action dimension (attitudes, actions), especially considering the physical and mental well-being aspects.

Published
2022
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74. ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Author

Brown, DA, Chadwick, MB, Capote, R, Kahler, AC, Trkov, A, Herman, MW, Sonzogni, AA, Danon, Y, Carlson, AD, Dunn, M, Smith, DL, Hale, GM, Arbanas, G, Arcilla, R, Bates, CR, Beck, B, Becker, B, Brown, F, Casperson, RJ, Conlin, J, Cullen, DE, Descalle, M-A, Firestone, R, Gaines, T, Guber, KH, Hawari, AI, Holmes, J, Johnson, TD, Kawano, T, Kiedrowski, BC, Koning, AJ, Kopecky, S, Leal, L, Lestone, JP, Lubitz, C, Damián, JI Márquez, Mattoon, CM, McCutchan, EA, Mughabghab, S, Navratil, P, Neudecker, D, Nobre, GPA, Noguere, G, Paris, M, Pigni, MT, Plompen, AJ, Pritychenko, B, Pronyaev, VG, Roubtsov, D, Rochman, D, Romano, P, Schillebeeckx, P, Simakov, S, Sin, M, Sirakov, I, Sleaford, B, Sobes, V, Soukhovitskii, ES, Stetcu, I, Talou, P, Thompson, I, van der Marck, S, Welser-Sherrill, L, Wiarda, D, White, M, Wormald, JL, Wright, RQ, Zerkle, M, Žerovnik, G, and Zhu, Y

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Rare Diseases, Affordable and Clean Energy, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

Published
2018

75. T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice

Author

Olmo Sonzogni, Daniel E. Zak, Maria Stella Sasso, Rochelle Lear, Alice Muntzer, Manuela Zonca, Katy West, Brian R. Champion, and James B. Rottman

Subjects
car t cells, t-sign oncolytic virus, solid tumor, xenograft, tumor microenvironment, re-program, metastases, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Although chimeric antigen receptor (CAR) T cells have emerged as highly effective treatments for patients with hematologic malignancies, similar efficacy has not been achieved in the context of solid tumors. There are several reasons for this disparity including a) fewer solid tumor target antigens, b) heterogenous target expression amongst tumor cells, c) poor trafficking of CAR T cells to the solid tumor and d) an immunosuppressive tumor microenvironment (TME). Oncolytic viruses have the potential to change this paradigm by a) directly lysing tumor cells and releasing tumor neoantigens, b) stimulating the local host innate immune response to release cytokines and recruit additional innate and adaptive immune cells, c) carrying virus-encoded transgenes to “re-program” the TME to a pro-inflammatory environment and d) promoting an adaptive immune response to the neoantigens in this newly permissive TME. Here we show that the Tumor-Specific Immuno-Gene (T-SIGn) virus NG-347 which encodes IFNα, MIP1α and CD80 synergizes with anti-EGFR CAR T cells as well as anti-HER-2 CAR T cells to clear A549 human tumor xenografts and their pulmonary metastases at doses which are subtherapeutic when each is used as a sole treatment. We show that NG-347 changes the TME to a pro-inflammatory environment resulting in the recruitment and activation of both CAR T cells and mouse innate immune cells. We also show that the transgenes encoded by the virus are critical as synergy is lost in their absence.

Published
2022
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76. A Rad-Hard Bandgap Voltage Reference for High Energy Physics Experiments

Author

Traversi, G., Gaioni, L., Manghisoni, M., Pezzoli, M., Ratti, L., Re, V., Riceputi, E., Sonzogni, M., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Saponara, Sergio, editor, and De Gloria, Alessandro, editor

Published
2020
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80. Total Absorption Gamma-Ray Spectroscopy of 87Br, 88Br and 94Rb Beta-Delayed Neutron Emitters

Author

Valencia, E., Tain, J. L., Algora, A., Agramunt, J., Rubio, B., Rice, S., Gelletly, W., Regan, P., Zakari-Issoufou, A. -A., Fallot, M., Porta, A., Rissanen, J., Eronen, T., Aysto, J., Batist, L., Bowry, M., Bui, V. M., Caballero-Folch, R., Cano-Ott, D., Elomaa, V. -V., Estevez, E., Farrelly, G. F., Garcia, A. R., Gomez-Hornillos, B., Gorlychev, V., Hakala, J., Jordan, M. D., Jokinen, A., Kolhinen, V. S., Kondev, F. G., Martinez, T., Mendoza, E., Moore, I., Penttila, H., Podolyak, Zs., Reponen, M., Sonnenschein, V., and Sonzogni, A. A.

Subjects
Nuclear Experiment
Abstract

We investigate the decay of 87Br, 88Br and 94Rb using total absorption gamma-ray spectroscopy. These important fission products are beta-delayed neutron emitters. Our data show considerable gamma-intensity, so far unobserved in high-resolution gamma-ray spectroscopy, from states at high excitation energy. We also find significant differences with the beta intensity that can be deduced from existing measurements of the beta spectrum. We evaluate the impact of the present data on reactor decay heat using summation calculations. Although the effect is relatively small it helps to reduce the discrepancy between calculations and integral measurements of the photon component for 235U fission at cooling times in the range 1 to 100 s. We also use summation calculations to evaluate the impact of present data on reactor antineutrino spectra. We find a significant effect at antineutrino energies in the range of 5 to 9 MeV. In addition, we observe an unexpected strong probability for gamma emission from neutron unbound states populated in the daughter nucleus. The gamma branching is compared to Hauser-Feshbach calculations which allow one to explain the large value for bromine isotopes as due to nuclear structure. However the branching for 94Rb, although much smaller, hints of the need to increase the radiative width by one order-of-magnitude. This leads to a similar increase in the calculated (n,gamma) cross section for this very neutron-rich nucleus with a potential impact on r-process abundance calculations.

Published
2016
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82. $\gamma$-soft $^{146}$Ba and the role of non-axial shapes at N ~ 90

Author

Mitchell, A. J., Lister, C. J., McCutchan, E. A., Albers, M., Ayangeakaa, A. D., Bertone, P. F., Carpenter, M. P., Chiara, C. J., Chowdhury, P., Clark, J. A., Copp, P., David, H. M., Deo, A. Y., DiGiovine, B., D'Olympia, N., Dungan, R., Harding, R. D., Harker, J., Hota, S. S., Janssens, R. V. F., Kondev, F. G., Liu, S. H., Ramayya, A. V., Rissanen, J., Savard, G., Seweryniak, D., Shearman, R., Sonzogni, A. A., Tabor, S. L., Walters, W. B., Wang, E., and Zhu, S.

Subjects
Nuclear Experiment
Abstract

Low-spin states in the neutron-rich, N = 90 nuclide $^{146}$Ba were populated following $\beta$-decay of $^{146}$Cs, with the goal of clarifying the development of deformation in Ba isotopes through delineation of their non-yrast structures. Fission fragments of $^{146}$Cs were extracted from a 1.7-Ci $^{252}$Cf source and mass-selected using the CARIBU facility. Low-energy ions were deposited at the center of a box of thin $\beta$ detectors, surrounded by a high-efficiency HPGe array. The new $^{146}$Ba decay scheme now contains 31 excited levels extending up to ~2.5 MeV excitation energy, double what was previously known. These data are compared to predictions from the Interacting Boson Approximation (IBA) model. It appears that the abrupt shape change found at N = 90 in Sm and Gd is much more gradual in Ba and Ce, due to an enhanced role of the $\gamma$ degree of freedom., Comment: 10 pages, 8 figures, accepted to Physical Review C

Published
2015
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84. Cosmic antihelium-3 nuclei sensitivity of the GAPS experiment

Author

Saffold, N., Aramaki, T., Bird, R., Boezio, M., Boggs, S.E., Bonvicini, V., Campana, D., Craig, W.W., von Doetinchem, P., Everson, E., Fabris, L., Fuke, H., Gahbauer, F., Garcia, I., Gerrity, C., Hailey, C.J., Hayashi, T., Kato, C., Kawachi, A., Kobayashi, S., Kozai, M., Lenni, A., Lowell, A., Manghisoni, M., Marcelli, N., Mognet, S.I., Munakata, K., Munini, R., Nakagami, Y., Olson, J., Ong, R.A., Osteria, G., Perez, K., Pope, I., Quinn, S., Re, V., Reed, M., Riceputi, E., Roach, B., Rogers, F., Ryan, J.L., Scotti, V., Shimizu, Y., Sonzogni, M., Sparvoli, R., Stoessl, A., Tiberio, A., Vannuccini, E., Wada, T., Xiao, M., Yamatani, M., Yoshida, A., Yoshida, T., Zampa, G., and Zweerink, J.

Published
2021
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85. Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Kerovec Sorić, Ivana, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, René, Cajková, Petra, Mixa, Vladimír, Sedláčková, Yvona, Knoppová, Lenka, Zlámalová (neé Květoňová), Alena, Vavřina, Martin, Žurek, Jiří, Hansen, Tom, Afshari, Arash, Bille, Anders Bastholm, Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Väli, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vähätalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Hervé, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Nouette Gaulain, Karine, Hamonic, Yann, Semjen, François, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cécile, Petry, Léa, Ros, Lilica, Zang, Aurélien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurélien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Brière, François, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Löffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schäfer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Schöler, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yücetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Söhle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Székely, Edgar, Kosik, Nandor, Maráczi, Veronika, Schnur, Janos, Csillag, Judit, Gál, János, Göbl, Gergely, Hauser, Balázs, Petróczy, András, Tövisházi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria Cristina, Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura Brigitta, Finamore, Simona Anna, Porro, Giuliana Anna, Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald Rogan, Favarato, Moreno, Locatelli, Bruno Guido, Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der Knijff-van Dortmont, Anouk, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella Mari, Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger Marie, Isern, Erik Ramon, Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Sílvia, Patuleia, Maria Domingas, Esteves, Catarina Cruz, Salgado, Helena, Santos, Maria João, Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyíri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Puric Racic, Selena, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanová, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Pirtovšek Štupnik, Špela, Méndez, Dolores, Pino, Gema, Rubio, Paloma, Izquierdo, Alberto, López, Silvia, González Serrano, Cristina, Cebrián, Jesús, Peleteiro, Ana, Del Rey de Diego, Pilar, Martínez García, Ernesto, Tormo de las Heras, Carolina, Troncoso Montero, Pablo, Arbona, Celia, Artés, David, Chamizo, Alicia, Serrano, Silvia, Suarez Comas, Montserrat, Escribá, Francisco, Auli, Cristina, Pérez Pardo, Osvaldo, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Villalobos Rico, María Isabel, Manrique Muñoz, Susana, García Martínez, Irene, Montferrer Estruch, Nuria, Vilardell Ortíz, Elena, Poves-Álvarez, Rodrigo, Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandström, Kerstin, Bengt, Sporre, Dörenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnström, Ann, Pontén, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bögli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Malär, Anna-Ursina, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse Çiğdem, Hatipoğlu, Zehra, Özcengiz, Dilek, Erdost, Hale Aksu, Öçmen, Elvan, Olguner, Çimen, Ayanoglu, Hilmi, Dincer, Pelin Corman, Umuroglu, Tumay, Azizoglu, Mustafa, Birbiçer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Wolfe Barry, Juliet, Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Scalia Catenacci, Stefano, Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Julia, Dowell, Prisca, Feijten, Pierre, Harlet, Sarah, Herbineaux, Brigitte, Leva, Benoît, Plichon, Katalin, Virág, Virag, Katalin, and Engelhardt, Thomas

Published
2021
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86. Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE)

Author

Breschan, Christian, Likar, Rudolf, Platzer, Manuela, Edelman, Isole, Eger, Johanes, Heschl, Stefan, Messerer, Brigitte, Vittinghof, Maria, Kroess, Ruth, Stichlberger, Martina, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Stevens, France, Berghmans, Johan, Bauters, Annemie, De Baerdemaeker, Luc, De Hert, Stefan, Lapage, Koen, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Wyffels, Piet, Lauweryns, Julie, Najafi, Nadia, Vundelinckx, Joris, Butković, Diana, Sorić, Ivana Kerovec, Kralik, Sandra, Markić, Ana, Azman, Josip, Markic, Josko, Pupacic, Daniela, Frelich, Michal, Reimer, Petr, Urbanec, Rene, Cajkova, Petra, Mixa, Vladimir, Sedlačkova, Yvona, Knoppova, Lenka, Zlamalova (nee Květoňova), Alena, Vavřina, Martin, Žurek, Jiři, Hansen, Tom, Afshari, Arash, Bille, Anders B., Ellekvist, Marguerite, Ilmoja, Mari-Liis, Moor, Reet, Kikas, Reet, Vali, Merle, Kallio, Kariantti, Reponen, Elisa, Suominen, Pertti, Suvanto, Sami, Vahatalo, Raisa, Kokki, Hannu, Kokki, Merja, Harju, Jarkko, Kokkonen, Miia, Vieri, Jenni, Manner, Tuula, Amory, Catherine, Ludot, Hugues, Bert, Dina, Godart, Juliette, Laffargue, Anne, Dupont, Herve, Urbina, Benjamin, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Bordes, Maryline, Gaulain, Karine Nouette, Hamonic, Yann, Semjen, Francois, Jacqmarcq, Olivier, Lejus-Bourdeau, Caroline, Magne, Cecile, Petry, Lea, Ros, Lilica, Zang, Aurelien, Bennis, Mehdi, Coustets, Bernard, Fesseau, Rose, Constant, Isabelle, Khalil, Eliane, Sabourdin, Nada, Audren, Noemie, Descarpentries, Thomas, Fabre, Fanny, Legrand, Aurelien, Druot, Emilie, Orliaguet, Gilles, Sabau, Lucie, Uhrig, Lynn, de la Briere, Francois, Jonckheer, Karin, Mission, Jean-Paul, Scordo, Lucia, Couchepin, Caroline, Dadure, Christophe, De la Arena, Pablo, Hertz, Laurent, Pirat, Philippe, Sola, Chrystelle, Bellon, Myriam, Dahmani, Souhayl, Julien-Marsollier, Florence, Michelet, Daphne, Depret-Donatien, Veronique, Lesage, Anne, Kaufmann, Jost, Laschat, Michael, Wappler, Frank, Becke, Karin, Brunner, Lena, Oppenrieder, Karin, Badelt, Gregor, Hochmuth, Karin, Koller, Bernhard, Reil, Anita, Richter, Sebastian, Fischer, Thomas, Diers, Anja, Schorer, Clemens, Weyland, Andreas, Cohausz, Ruth, Kretz, Franz-Josef, Loffler, Michaela, Wilbs, Markus, Hoehne, Claudia, Ulrici, Johanna, Goeters, Christiane, Flinspach, Armin, Klages, Matthias, Lindau, Simone, Messroghli, Leila, Zacharowski, Kai, Eisner, Christoph, Mueller, Thomas, Richter, Daniel, Schafer, Melanie, Weigand, Markus, Weiterer, Sebastian, Ochsenreiter, Miriam, Scholer, Michael, Terboven, Tom, Eggemann, Isabel, Haussmann, Sascha, Leister, Nicolas, Menzel, Christoph, Trieschmann, Uwe, Yucetepe, Sirin, Keilig, Susanna, Kranke, Peter, Jelting, Yvonne, Baehner, Torsten, Ellerkmann, Richard, Ghamari, Shahab, Neumann, Claudia, Sohle, Martin, Chloropoulou, Pelagia, Ntritsou, Vagia, Papagiannopoulou, Pinelopi, Garini, Eleana, Karafotia, Afroditi, Mammi, Panagoula, Bali, Evangelia, Iordanidou, Despoina, Malisiova, Anna, Polyzoi, Artemis, Tsiotou, Adelais, Sapi, Erzsebet, Szekely, Edgar, Kosik, Nandor, Maraczi, Veronika, Schnur, Janos, Csillag, Judit, Gal, Janos, Gobl, Gergely, Hauser, Balazs, Petroczy, Andras, Tovishazi, Gyula, Blain, Stuart, Gallagher, Sarah, Harte, Sinead, Jackson, Mandy, Meehan, Emma, Nawoor, Zeenat, O’Hare, Brendan, Ross, Mark, Lerro, Daniela, Astuto, Marinella, Grasso, Chiara, Scalisi, Rita, Frasacco, Giulia, Lenares, Elena, Leone, Roberto, Grazzini, Maurizia, Minardi, Carmelo, Zadra, Nicola, Cinnella, Gilda, Cotoia, Antonella, Galante, Dario, De Lorenzo, Brita, Kuppers, Beate, Bottazzi, Giulia, Caramelli, Fabio, Mondardini, Maria C., Rossetti, Emanuele, Picardo, Sergio, Vittori, Alessandro, Camporesi, Anna, Wolfler, Andrea, Calderini, Edoardo, Colantonio, Laura B., Finamore, Simona A., Porro, Giuliana A., Bonfiglio, Rachele, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Mattioli, Girolamo, Micalizzi, Camilla, Montaguti, Alessia, Pistorio, Angela, Zanaboni, Clelia, Guddo, Anna, Neba, Gerald R., Favarato, Moreno, Locatelli, Bruno G., Maffioletti, Micol, Sonzogni, Valter, Garra, Rossella, Sammartino, Maria, Sbaraglia, Fabio, Cortegiani, Andrea, Moscarelli, Alessandra, Attanasi, Elena, Tesoro, Simonetta, Agapiti, Cristina, Pinzoni, Francesca, Vezzoli, Cesare, Bilotta, Federico, Barzdina, Arta, Straume, Zane, Zundane, Anda, Lukosiene, Laura, Maraulaite, Irena, Razlevice, Ilona, Schmitz, Bernd, Mifsud, Stephanie, Aehling, Carolin, Allison, Celia, De Boer, Rients, Emal, Dina, Stevens, Markus, Buitenhuis, Marielle, de Graaff, Jurgen, De Liefde, Inge, Machotta, Andreas, Scoones, Gail, Staals, Lonneke, Tomas, Jeremy, Van der, Anouk, Dortmont, Knijff-van, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Schafrat, Eva, Schreiber, Jan, Vermeulen, Petronella M., Hendriks, Mark, Lako, Sandra, Voet-Lindner, Marieke, Pieters, Barbe, Scheffer, Gert-Jan, Tielens, Luc, Absalom, Anthony R., Bergsma, Margot, De Ruiter, Joke, Meier, Sascha, Volkers, Martin, Zweers, Tjerk, Beukers, Anne M., Boer, Christa, Dertinger, Jurgen, Numan, Sandra, Van Zaane, Bas, Boerke, Wenche B., Ekiz, Nil, Stensrud, Kristoffer, Drage, Inger M., Isern, Erik R., Bartkowska-Sniatkowska, Alicja, Grzeskowiak, Malgorzata, Juzwa-Sobieraj, Magdalena, Rosada-Kurasińska, Jowita, Baranowski, Artur, Jakubowska, Karina, Lewandowska, Dorota, Mierzewska-Schmidt, Magdalena, Sawicki, Piotr, Urban-Lechowicz, Magdalena, Przemyslaw, Pomianek, Zielinska, Marzena, Leal, Teresa, Soares, Maria, Pina, Pedro, Pinho, Silvia, Patuleia, Maria Domingas, Esteves, Catarina C., Salgado, Helena, Santos, Maria J., Badeti, Rodica, Cindea, Iulia, Oana, Loredana, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Tabacaru, Radu, Trante, Irina, Munteanu, Valentin, Morariu, Mihai, Nyiri, Emese, Budic, Ivana, Marjanovic, Vesna, Drašković, Biljana, Pandurov, Marina, Ilic, Jordanka, Mandras, Ana, Rados, Zdenka, Stankovic, Nikola, Suica, Maja, Vasiljevic, Sladjana, Knezevic, Mirjana, Milojevic, Irina, Petrov, Ivana, Racic, Selena Puric, Simic, Dusica, Simic, Irena, Stevic, Marija, Vulicevic, Irena, Cabanova, Barbora, Hanula, Miloslav, Berger, Jelena, Janjatovic, Darja, Štupnik, Špela P., Kohn, Ivan, Lindestam, Ulf, Reinhard, Jarl, Castellheim, Albert, Sandstrom, Kerstin, Bengt, Sporre, Dorenberg, Rainer, Frykholm, Peter, Garcia, Maria, Kvarnstrom, Ann, Ponten, Emma, Bruelisauer, Thomas, Erdoes, Gabor, Kaiser, Heiko, Marchon, Mathias, Riva, Thomas, Seiler, Stefan, Bogli, Yann, Dolci, Mirko, Marcucci, Carine, Habre, Walid, Pichon, Isabelle, Vutskits, Laszlo, Casutt, Mattias, Holzle, Martin, Hurni, Thomas, Johr, Martin, Anna-Ursina, Malar, Mauch, Jacqueline, Erb, Thomas, Oeinck, Karin, Akin, Mine, Keskin, Gulsen, Senayli, Yesim, Kaya, Guner, Kendigelen, Pinar, Tutuncu, Ayse C., Hatipoğlu, Zehra, Ozcengiz, Dilek, Erdost, Hale Aksu, Ocmen, Elvan, Olguner, Cimen, Ayanoglu, Hilmi, Dincer, Pelin C., Umuroglu, Tumay, Azizoglu, Mustafa, Birbicer, Handan, Doruk, Nurcan, Sagun, Aslı, Baris, Sibel, Dmytriiev, Dmytro, Kuchi, Sridevi, Masip, Nuria, Brooks, Peter, Hare, Alison, Ahmad, Nargis, Casey, Michelle, De Silva, Sam, Dobby, Nadine, Krishnan, Prakash, Sogbodjor, L. Amaki, Walker, Ellie, Walker, Suellen, King, Stephanie, Nicholson, Katy, Quinney, Michelle, Stevens, Paul, Blevin, Andrew, Giombini, Mariangela, Goonasekera, Chulananda, Adil, Sadia, Bew, Stephanie, Bodlani, Carol, Gilpin, Dan, Jinks, Stephanie, Malarkkan, Nalini, Miskovic, Alice, Pad, Rebecca, Barry, Juliet W., Abbott, Joy, Armstrong, James, Cooper, Natalie, Crate, Lindsay, Emery, John, James, Kathryn, King, Hannah, Martin, Paul, Catenacci, Stefano S., Bomont, Rob, Smith, Paul, Mele, Sara, Verzelloni, Alessandra, Dix, Philippa, Bell, Graham, Gordeva, Elena, McKee, Lesley, Ngan, Esther, Scheffczik, Jutta, Tan, Li-En, Worrall, Mark, Cassar, Carmel, Goddard, Kevin, Barlow, Victoria, Oshan, Vimmi, Shah, Khairi, Bell, Sarah, Daniels, Lisa, Gandhi, Monica, Pachter, David, Perry, Chris, Robertson, Andrew, Scott, Carmen, Waring, Lynne, Barnes, David, Childs, Sophie, Norman, Joanne, Sunderland, Robin, Virag, Katalin, Hansen, Tom G., Harlet, Pierre, Walker, Suellen M., de Graaff, Jurgen C., and Engelhardt, Thomas

Published
2021
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88. Stones

Author

Keller, Etienne Xavier, primary, De Coninck, Vincent, additional, Traxer, Olivier, additional, Shvero, Asaf, additional, Kleinmann, Nir, additional, Hubosky, Scott G., additional, Doizi, Steeve, additional, Hardacker, Thomas J., additional, Bagley, Demetrius H., additional, and Sonzogni-Cella, Maryann, additional

Published
2021
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91. The identification of airbursts in the past: insights from the BIT-58 layer

Author

van Ginneken, Matthias, Harvey, Ralph P., Goderis, Steven, Artemieva, Natalia, Boslough, Mark, Maeda, Ryoga, Gattacceca, Jérôme, Folco, Luigi, Yamaguchi, Akira, Sonzogni, Corinne, Wozniakiewicz, Penelope J., van Ginneken, Matthias, Harvey, Ralph P., Goderis, Steven, Artemieva, Natalia, Boslough, Mark, Maeda, Ryoga, Gattacceca, Jérôme, Folco, Luigi, Yamaguchi, Akira, Sonzogni, Corinne, and Wozniakiewicz, Penelope J.

Abstract

Airbursts are estimated to be the most frequent type of destructive impact events. Yet, confirmation of these events is elusive, resulting in a major gap in the impact record of Earth. The recent discovery of igneous chondritic spherules produced during a new type of touchdown airburst 430 thousand years (kyr) ago over Antarctica, in which a projectile vapor jet interacts with the Antarctic ice sheet, provided the first trace of such an impact in the geological record. In terms of petrology and geochemistry, particles constituting the BIT-58 dust horizon, which was found in surface ice at near Allan Hills in Antarctica, are almost identical to those produced 430 kyr ago. We demonstrate here that BIT-58 particles were indeed formed during a touchdown event between 2.3 and 2.7 million years (Myr) ago. This represents the oldest record of an airburst on Earth identified to date. Slight geochemical differences with 430 kyr old airburst spherules provide additional constraints on spherule condensation in large airburst plumes. Finding confirmation of airbursts in the paleorecord can provide insight into the frequency of the most hazardous impacts and, thus, has implications for planetary defence.

Published
2024

92. A global compilation of diatom silica oxygen isotope records from lake sediment – trends and implications for climate reconstruction

Author

Meister, Philip, Alexandre, Anne, Bailey, Hannah, Barker, Philip, Biskaborn, Boris K., Broadman, Ellie, Cartier, Rosine, Chapligin, Bernhard, Couapel, Martine, Dean, Jonathan R., Diekmann, Bernhard, Harding, Poppy, Henderson, Andrew C. G., Hernandez, Armand, Herzschuh, Ulrike, Kostrova, Svetlana S., Lacey, Jack, Leng, Melanie J., Lücke, Andreas, Mackay, Anson W., Magyari, Eniko Katalin, Narancic, Biljana, Porchier, Cécile, Rosqvist, Gunhild, Shemesh, Aldo, Sonzogni, Corinne, Swann, George E. A., Sylvestre, Florence, Meyer, Hanno, Meister, Philip, Alexandre, Anne, Bailey, Hannah, Barker, Philip, Biskaborn, Boris K., Broadman, Ellie, Cartier, Rosine, Chapligin, Bernhard, Couapel, Martine, Dean, Jonathan R., Diekmann, Bernhard, Harding, Poppy, Henderson, Andrew C. G., Hernandez, Armand, Herzschuh, Ulrike, Kostrova, Svetlana S., Lacey, Jack, Leng, Melanie J., Lücke, Andreas, Mackay, Anson W., Magyari, Eniko Katalin, Narancic, Biljana, Porchier, Cécile, Rosqvist, Gunhild, Shemesh, Aldo, Sonzogni, Corinne, Swann, George E. A., Sylvestre, Florence, and Meyer, Hanno

Published
2024
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93. Nuclear Data Needs and Capabilities for Applications

Author

Bernstein, Lee, Brown, David, Hurst, Aaron, Kelly, John, Kondev, Filip, McCutchan, Elizabeth, Nesaraja, Caroline, Slaybaugh, Rachel, and Sonzogni, Alejandro

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The Workshop on Nuclear Data Needs and Capabilities for Applications (NDNCA) was held at Lawrence Berkeley National Laboratory (LBNL) on 27-29 May 2015. The goals of NDNCA were compile nuclear data needs across a wide spectrum of applied nuclear science, and to provide a summary of associated capabilities (accelerators, reactors, spectrometers, etc.) available for required measurements. This document represents the results of the workshop and a compilation of other recent documents assessing nuclear data needs for the above-mentioned applications., Comment: A high resolution version of the report in both pdf and MSWord format, and the matrix of nuclear data needs in excel format, can be found online at http://bang.berkeley.edu/events/ndnca/whitepaper/

Published
2015

94. Enhanced Gamma-Ray Emission from Neutron Unbound States Populated in Beta Decay

Author

Tain, J. L., Valencia, E., Algora, A., Agramunt, J., Rubio, B., Rice, S., Gelletly, W., Regan, P., Zakari-Issoufou, A. -A., Fallot, M., Porta, A., Rissanen, J., Eronen, T., Aysto, J., Batist, L., Bowry, M., Bui, V. M., Caballero-Folch, R., Cano-Ott, D., Elomaa, V. -V., Estevez, E., Farrelly, G. F., Garcia, A. R., Gomez-Hornillos, B., Gorlychev, V., Hakala, J., Jordan, M. D., Jokinen, A., Kolhinen, V. S., Kondev, F. G., Martinez, T., Mendoza, E., Moore, I., Penttila, H., Podolyak, Zs., Reponen, M., Sonnenschein, V., and Sonzogni, A. A.

Subjects
Nuclear Experiment
Abstract

Total absorption spectroscopy was used to investigate the beta-decay intensity to states above the neutron separation energy followed by gamma-ray emission in 87,88Br and 94Rb. Accurate results were obtained thanks to a careful control of systematic errors. An unexpectedly large gamma intensity was observed in all three cases extending well beyond the excitation energy region where neutron penetration is hindered by low neutron energy. The gamma branching as a function of excitation energy was compared to Hauser-Feshbach model calculations. For 87Br and 88Br the gamma branching reaches 57% and 20% respectively, and could be explained as a nuclear structure effect. Some of the states populated in the daughter can only decay through the emission of a large orbital angular momentum neutron with a strongly reduced barrier penetrability. In the case of neutron-rich 94Rb the observed 4.5% branching is much larger than the calculations performed with standard nuclear statistical model parameters, even after proper correction for fluctuation effects on individual transition widths. The difference can be reconciled introducing an enhancement of one order-of-magnitude in the photon strength to neutron strength ratio. An increase in the photon strength function of such magnitude for very neutron-rich nuclei, if it proved to be correct, leads to a similar increase in the (n,gamma) cross section that would have an impact on r-process abundance calculations.

Published
2015
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95. The $^{136}$Xe + $^{208}$Pb reaction: A test of models of multi-nucleon transfer reactions

Author

Barrett, J. S., Yanez, R., Loveland, W., Zhu, S., Ayangeakaa, A. D., Carpenter, M. P., Greene, J. P., Janssens, R. V. F., Lauritsen, T., McCutchan, E. A., Sonzogni, A. A., Chiara, C. J., Harker, J. L., and Walters, W. B.

Subjects
Nuclear Experiment
Abstract

The yields of over 200 projectile-like fragments (PLFs) and target-like fragments (TLFs) from the interaction of (E$_{c.m.}$=450 MeV) $^{136}$Xe with a thick target of $^{208}$Pb were measured using Gammasphere and off-line $\gamma$-ray spectroscopy, giving a comprehensive picture of the production cross sections in this reaction.The measured yields were compared to predictions of the GRAZING model and the predictions of Zagrebaev and Greiner using a quantitative metric, the theory evaluation factor, {\bf tef}. The GRAZING model predictions are adequate for describing the yields of nuclei near the target or projectile but grossly underestimate the yields of all other products. The predictions of Zagrebaev and Greiner correctly describe the magnitude and maxima of the observed TLF transfer cross sections for a wide range of transfers ($\Delta$Z = -8 to $\Delta$Z = +2). However for $\Delta$Z =+4, the observed position of the maximum in the distribution is four neutrons richer than the predicted maximum. The predicted yields of the neutron-rich N=126 nuclei exceed the measured values by two orders of magnitude. Correlations between TLF and PLF yields are discussed.

Published
2015

96. Total Absorption Spectroscopy Study of $^{92}$Rb Decay: A Major Contributor to Reactor Antineutrino Spectrum Shape

Author

Zakari-Issoufou, A. -A., Fallot, M., Porta, A., Algora, A., Tain, J. L., Valencia, E., Rice, S., Bui, V. M, Cormon, S., Estienne, M., Agramunt, J., Äystö, J., Bowry, M., Briz, J. A., Caballero-Folch, R., Cano-Ott, D., Cucoanes, A., Elomaa, V. -V., Eronen, T., Estévez, E., Farrelly, G. F., Garcia, A. R., Gelletly, W., Gomez-Hornillos, M. B, Gorlychev, V., Hakala, J., Jokinen, A., Jordan, M. D., Kankainen, A., Karvonen, P., Kolhinen, V. S., Kondev, F. G, Martinez, T., Mendoza, E., Molina, F., Moore, I., Perez-Cerdán, A. B., Podolyák, Zs., Penttilä, H., Regan, P. H., Reponen, M., Rissanen, J., Rubio, B., Shiba, T., Sonzogni, A. A., Weber, C., and collaboration, IGISOL

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The antineutrino spectra measured in recent experiments at reactors are inconsistent with calculations based on the conversion of integral beta spectra recorded at the ILL reactor. $^{92}$Rb makes the dominant contribution to the reactor spectrum in the 5-8 MeV range but its decay properties are in question. We have studied $^{92}$Rb decay with total absorption spectroscopy. Previously unobserved beta feeding was seen in the 4.5-5.5 region and the GS to GS feeding was found to be 87.5(25)%. The impact on the reactor antineutrino spectra calculated with the summation method is shown and discussed., Comment: 6 pages, 3 figures

Published
2015
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97. The Intermediate Neutrino Program

Author

Adams, C., Alonso, J. R., Ankowski, A. M., Asaadi, J. A., Ashenfelter, J., Axani, S. N., Babu, K., Backhouse, C., Band, H. R., Barbeau, P. S., Barros, N., Bernstein, A., Betancourt, M., Bishai, M., Blucher, E., Bouffard, J., Bowden, N., Brice, S., Bryan, C., Camilleri, L., Cao, J., Carlson, J., Carr, R. E., Chatterjee, A., Chen, M., Chen, S., Chiu, M., Church, E. D., Collar, J. I., Collin, G., Conrad, J. M., Convery, M. R., Cooper, R. L., Cowen, D., Davoudiasl, H., De Gouvea, A., Dean, D. J., Deichert, G., Descamps, F., DeYoung, T., Diwan, M. V., Djurcic, Z., Dolinski, M. J., Dolph, J., Donnelly, B., Dwyer, D. A., Dytman, S., Efremenko, Y., Everett, L. L., Fava, A., Figueroa-Feliciano, E., Fleming, B., Friedland, A., Fujikawa, B. K., Gaisser, T. K., Galeazzi, M., Galehouse, D. C., Galindo-Uribarri, A., Garvey, G. T., Gautam, S., Gilje, K. E., Gonzalez-Garcia, M., Goodman, M. C., Gordon, H., Gramellini, E., Green, M. P., Guglielmi, A., Hackenburg, R. W., Hackenburg, A., Halzen, F., Han, K., Hans, S., Harris, D., Heeger, K. M., Herman, M., Hill, R., Holin, A., Huber, P., Jaffe, D. E., Johnson, R. A., Joshi, J., Karagiorgi, G., Kaufman, L. J., Kayser, B., Kettell, S. H., Kirby, B. J., Klein, J. R., Kolomensky, Yu. G., Kriske, R. M., Lane, C. E., Langford, T. J., Lankford, A., Lau, K., Learned, J. G., Ling, J., Link, J. M., Lissauer, D., Littenberg, L., Littlejohn, B. R., Lockwitz, S., Lokajicek, M., Louis, W. C., Luk, K., Lykken, J., Marciano, W. J., Maricic, J., Markoff, D. M., Caicedo, D. A. Martinez, Mauger, C., Mavrokoridis, K., McCluskey, E., McKeen, D., McKeown, R., Mills, G., Mocioiu, I., Monreal, B., Mooney, M. R., Morfin, J. G., Mumm, P., Napolitano, J., Neilson, R., Nelson, J. K., Nessi, M., Norcini, D., Nova, F., Nygren, D. R., Gann, G. D. Orebi, Palamara, O., Parsa, Z., Patterson, R., Paul, P., Pocar, A., Qian, X., Raaf, J. L., Rameika, R., Ranucci, G., Ray, H., Reyna, D., Rich, G. C., Rodrigues, P., Romero, E. Romero, Rosero, R., Rountree, S. D., Rybolt, B., Sanchez, M. C., Santucci, G., Schmitz, D., Scholberg, K., Seckel, D., Shaevitz, M., Shrock, R., Smy, M. B., Soderberg, M., Sonzogni, A., Sousa, A. B., Spitz, J., John, J. M. St., Stewart, J., Strait, J. B., Sullivan, G., Svoboda, R., Szelc, A. M., Tayloe, R., Thomson, M. A., Toups, M., Vacheret, A., Vagins, M., Van de Water, R. G., Vogelaar, R. B., Weber, M., Weng, W., Wetstein, M., White, C., White, B. R., Whitehead, L., Whittington, D. W., Wilking, M. J., Wilson, R. J., Wilson, P., Winklehner, D., Winn, D. R., Worcester, E., Yang, L., Yeh, M., Yokley, Z. W., Yoo, J., Yu, B., Yu, J., and Zhang, C.

Subjects
High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop., Comment: pdfLaTeX, 31 pages, 1 figure, minor modification to 0nuBB discussion

Published
2015

99. In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease.

Author

Sonzogni, Elisa, Martinelli, Giulia, Fumagalli, Marco, Maranta, Nicole, Pozzoli, Carola, Bani, Corinne, Marrari, Luigi Alberto, Di Lorenzo, Chiara, Sangiovanni, Enrico, Dell'Agli, Mario, and Piazza, Stefano

Abstract

Sulforaphane is considered the bioactive metabolite of glucoraphanin after dietary consumption of broccoli sprouts. Although both molecules pass through the gut lumen to the large intestine in stable form, their biological impact on the first intestinal tract is poorly described. In celiac patients, the function of the small intestine is affected by celiac disease (CD), whose severe outcomes are controlled by gluten-free dietary protocols. Nevertheless, pathological signs of inflammation and oxidative stress may persist. The aim of this study was to compare the biological activity of sulforaphane with its precursor glucoraphanin in a cellular model of gliadin-induced inflammation. Human intestinal epithelial cells (CaCo-2) were stimulated with a pro-inflammatory combination of cytokines (IFN-γ, IL-1β) and in-vitro-digested gliadin, while oxidative stress was induced by H2O2. LC-MS/MS analysis confirmed that sulforaphane from broccoli sprouts was stable after simulated gastrointestinal digestion. It inhibited the release of all chemokines selected as inflammatory read-outs, with a more potent effect against MCP-1 (IC50 = 7.81 µM). On the contrary, glucoraphanin (50 µM) was inactive. The molecules were unable to counteract the oxidative damage to DNA (γ-H2AX) and catalase levels; however, the activity of NF-κB and Nrf-2 was modulated by both molecules. The impact on epithelial permeability (TEER) was also evaluated in a Transwell® model. In the context of a pro-inflammatory combination including gliadin, TEER values were recovered by neither sulforaphane nor glucoraphanin. Conversely, in the context of co-culture with activated macrophages (THP-1), sulforaphane inhibited the release of MCP-1 (IC50 = 20.60 µM) and IL-1β (IC50 = 1.50 µM) only, but both molecules restored epithelial integrity at 50 µM. Our work suggests that glucoraphanin should not merely be considered as just an inert precursor at the small intestine level, thus suggesting a potential interest in the framework of CD. Its biological activity might imply, at least in part, molecular mechanisms different from sulforaphane. [ABSTRACT FROM AUTHOR]

Published
2024
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100. Mechanical power ratio threshold for ventilator-induced lung injury.

Author

D'Albo, Rosanna, Pozzi, Tommaso, Nicolardi, Rosmery V., Galizia, Mauro, Catozzi, Giulia, Ghidoni, Valentina, Donati, Beatrice, Romitti, Federica, Herrmann, Peter, Busana, Mattia, Gattarello, Simone, Collino, Francesca, Sonzogni, Aurelio, Camporota, Luigi, Marini, John J., Moerer, Onnen, Meissner, Konrad, and Gattinoni, Luciano

Subjects
CENTRAL venous pressure, RESPIRATORY organs, PULMONARY artery, WATER-electrolyte balance (Physiology), LUNG injuries
Abstract

Rationale: Mechanical power (MP) is a summary variable incorporating all causes of ventilator-induced-lung-injury (VILI). We expressed MP as the ratio between observed and normal expected values (MPratio). Objective: To define a threshold value of MPratio leading to the development of VILI. Methods: In a population of 82 healthy pigs, a threshold of MPratio for VILI, as assessed by histological variables and confirmed by using unsupervised cluster analysis was 4.5. The population was divided into two groups with MPratio above or below the threshold. Measurements and main results: We measured physiological variables every six hours. At the end of the experiment, we measured lung weight and wet-to-dry ratio to quantify edema. Histological samples were analyzed for alveolar ruptures, inflammation, alveolar edema, atelectasis. An MPratio threshold of 4.5 was associated with worse injury, lung weight, wet-to-dry ratio and fluid balance (all p < 0.001). After 48 h, in the two MPratio clusters (above or below 4.5), respiratory system elastance, mean pulmonary artery pressure and physiological dead space differed by 32%, 36% and 22%, respectively (all p < 0.001), being worse in the high MPratio group. Also, the changes in driving pressure, lung elastance, pulmonary artery occlusion pressure, central venous pressure differed by 17%, 64%, 8%, 25%, respectively (all p < 0.001). Limitations: The main limitation of this study is its retrospective design. In addition, the computation for the expected MP in pigs is based on arbitrary criteria. Different values of expected MP may change the absolute value of MP ratio but will not change the concept of the existence of an injury threshold. Conclusions: The concept of MPratio is a physiological and intuitive way to quantify the risk of ventilator-induced lung injury. Our results suggest that a mechanical power ratio > 4.5 MPratio in healthy lungs subjected to 48 h of mechanical ventilation appears to be a threshold for the development of ventilator-induced lung injury, as indicated by the convergence of histological, physiological, and anatomical alterations. In humans and in lungs that are already injured, this threshold is likely to be different. [ABSTRACT FROM AUTHOR]

Published
2024
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