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52. Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).

Author

Baker, Laura D., Snyder, Heather M., Espeland, Mark A., Whitmer, Rachel A., Kivipelto, Miia, Woolard, Nancy, Katula, Jeffrey, Papp, Kathryn V., Ventrelle, Jennifer, Graef, Sarah, Hill, Marcus A., Rushing, Scott, Spell, Julia, Lovato, Laura, Felton, Deborah, Williams, Benjamin J., Ghadimi Nouran, Mina, Raman, Rema, Ngandu, Tiia, and Solomon, Alina

Abstract

INTRODUCTION: The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans. METHODS: U.S. POINTER was planned as a 2‐year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well‐established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER. RESULTS: U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing. DISCUSSION: U.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies. [ABSTRACT FROM AUTHOR]

Published
2024
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53. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

de Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel, Antúnez, Carmen, Antonell, Anna, Tankard, Rick M., Bis, Joshua C., Sims, Rebecca, Bellenguez, Céline, Quintela, Inés, González-Perez, Antonio, Calero, Miguel, Macías, Juan, Blesa, Rafael, Cervera-Carles, Laura, Menéndez-González, Manuel, Royo, Jose Luís, Moreno, Fermin, Huerto Vilas, Raquel, Baquero, Miquel, Diez-Fairen, Mónica, Lage, Carmen, García-González, Pablo, Valero, Sergi, Ullgren, Abbe, Naj, Adam C., Lemstra, Afina W., Benussi, Alberto, Rábano, Alberto, Padovani, Alessandro, Squassina, Alessio, de Mendonça, Alexandre, Arias Pastor, Alfonso, Kok, Almar A. L., Meggy, Alun, Pastor, Ana Belén, Espinosa, Ana, Corma-Gómez, Anaïs, Sanabria, Ángela, DeStefano, Anita L., Schneider, Anja, Haapasalo, Annakaisa, Kinhult Ståhlbom, Anne, Tybjærg-Hansen, Anne, Hartmann, Annette M., Spottke, Annika, Corbatón-Anchuelo, Arturo, Rongve, Arvid, Borroni, Barbara, Arosio, Beatrice, Nacmias, Benedetta, Nordestgaard, Børge G., Kunkle, Brian W., Charbonnier, Camille, Masullo, Carlo, Martínez Rodríguez, Carmen, Muñoz-Fernandez, Carmen, Dufouil, Carole, Graff, Caroline, Ferreira, Catarina B., Chillotti, Caterina, Reynolds, Chandra A., Fenoglio, Chiara, Van Broeckhoven, Christine, Clark, Christopher, Pisanu, Claudia, Satizabal, Claudia L., Holmes, Clive, Buiza-Rueda, Dolores, Aarsland, Dag, Rujescu, Dan, Alcolea, Daniel, Galimberti, Daniela, Wallon, David, Seripa, Davide, Grünblatt, Edna, Dardiotis, Efthimios, Düzel, Emrah, Scarpini, Elio, Conti, Elisa, Rubino, Elisa, Gelpi, Ellen, Rodriguez-Rodriguez, Eloy, Duron, Emmanuelle, Boerwinkle, Eric, Ferri, Evelyn, Tagliavini, Fabrizio, Küçükali, Fahri, Pasquier, Florence, Sanchez-Garcia, Florentino, Mangialasche, Francesca, Jessen, Frank, Nicolas, Gaël, Selbæk, Geir, Ortega, Gemma, Chêne, Geneviève, Hadjigeorgiou, Georgios, Rossi, Giacomina, Spalletta, Gianfranco, Giaccone, Giorgio, Grande, Giulia, Binetti, Giuliano, Papenberg, Goran, Hampel, Harald, Bailly, Henri, Zetterberg, Henrik, Soininen, Hilkka, Karlsson, Ida K., Alvarez, Ignacio, Appollonio, Ildebrando, Giegling, Ina, Skoog, Ingmar, Saltvedt, Ingvild, Rainero, Innocenzo, Rosas Allende, Irene, Hort, Jakub, Diehl-Schmid, Janine, Van Dongen, Jasper, Vidal, Jean-Sebastien, Lehtisalo, Jenni, Wiltfang, Jens, Thomassen, Jesper Qvist, Kornhuber, Johannes, Haines, Jonathan L., Vogelgsang, Jonathan, Pineda, Juan A., Fortea, Juan, Popp, Julius, Deckert, Jürgen, Buerger, Katharina, Morgan, Kevin, Fließbach, Klaus, Sleegers, Kristel, Molina-Porcel, Laura, Kilander, Lena, Weinhold, Leonie, Farrer, Lindsay A., Wang, Li-San, Kleineidam, Luca, Farotti, Lucia, Parnetti, Lucilla, Tremolizzo, Lucio, Hausner, Lucrezia, Benussi, Luisa, Froelich, Lutz, Ikram, M. Arfan, Deniz-Naranjo, M. Candida, Tsolaki, Magda, Rosende-Roca, Maitée, Löwenmark, Malin, Hulsman, Marc, Spallazzi, Marco, Pericak-Vance, Margaret A., Esiri, Margaret, Bernal Sánchez-Arjona, María, Dalmasso, Maria Carolina, Martínez-Larrad, María Teresa, Arcaro, Marina, Nöthen, Markus M., Fernández-Fuertes, Marta, Dichgans, Martin, Ingelsson, Martin, Herrmann, Martin J., Scherer, Martin, Vyhnalek, Martin, Kosmidis, Mary H., Yannakoulia, Mary, Schmid, Matthias, Ewers, Michael, Heneka, Michael T., Wagner, Michael, Scamosci, Michela, Kivipelto, Miia, Hiltunen, Mikko, Zulaica, Miren, Alegret, Montserrat, Fornage, Myriam, Roberto, Natalia, van Schoor, Natasja M., Seidu, Nazib M., Banaj, Nerisa, Armstrong, Nicola J., Scarmeas, Nikolaos, Scherbaum, Norbert, Goldhardt, Oliver, Hanon, Oliver, Peters, Oliver, Skrobot, Olivia Anna, Quenez, Olivier, Lerch, Ondrej, Bossù, Paola, Caffarra, Paolo, Dionigi Rossi, Paolo, Sakka, Paraskevi, Mecocci, Patrizia, Hoffmann, Per, Holmans, Peter A., Fischer, Peter, Riederer, Peter, Yang, Qiong, Marshall, Rachel, Kalaria, Rajesh N., Mayeux, Richard, Vandenberghe, Rik, Cecchetti, Roberta, Ghidoni, Roberta, Frikke-Schmidt, Ruth, Sorbi, Sandro, Hägg, Sara, Engelborghs, Sebastiaan, Helisalmi, Seppo, Botne Sando, Sigrid, Kern, Silke, Archetti, Silvana, Boschi, Silvia, Fostinelli, Silvia, Gil, Silvia, Mendoza, Silvia, Mead, Simon, Ciccone, Simona, Djurovic, Srdjan, Heilmann-Heimbach, Stefanie, Riedel-Heller, Steffi, Kuulasmaa, Teemu, del Ser, Teodoro, Lebouvier, Thibaud, Polak, Thomas, Ngandu, Tiia, Grimmer, Timo, Bessi, Valentina, Escott-Price, Valentina, Giedraitis, Vilmantas, Deramecourt, Vincent, Maier, Wolfgang, Jian, Xueqiu, Pijnenburg, Yolande A. L., Smith, A. David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G., Janowitz, Daniel, Craig, David, Mann, David M., Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M., Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R. L. C., Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M., Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J., Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C., Salvadori, Nicola, Hooper, Nigel M., Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M., Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M.T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J.A., Preckler, S., Quintela, I., Real, L.M., Rosende-Roca, M., Ruiz, A., Sáez, M.E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A.D., Alarcón-Martín, E., Alonso, M.D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Bullido, M.J., Burguera, J.A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M.J., Clarimón, J., Cruz-Gamero, J.M., de Pancorbo, M.M., del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., Garcia Madrona, S., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M.A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J.L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J.L., Sanchez del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M.P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W., Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Kehoe, Patrick Gavin, Garcia-Ribas, Guillermo, Sánchez-Juan, Pascual, Pastor, Pau, Pérez-Tur, Jordi, Piñol-Ripoll, Gerard, Lopez de Munain, Adolfo, García-Alberca, Jose María, Bullido, María J., Álvarez, Victoria, Lleó, Alberto, Real, Luis M., Mir, Pablo, Medina, Miguel, Scheltens, Philip, Holstege, Henne, Marquié, Marta, Sáez, María Eugenia, Carracedo, Ángel, Amouyel, Philippe, Schellenberg, Gerard D., Williams, Julie, Seshadri, Sudha, van Duijn, Cornelia M., Mather, Karen A., Sánchez-Valle, Raquel, Serrano-Ríos, Manuel, Orellana, Adelina, Tárraga, Lluís, Blennow, Kaj, Huisman, Martijn, Andreassen, Ole A., Posthuma, Danielle, Clarimón, Jordi, Boada, Mercè, van der Flier, Wiesje M., Ramirez, Alfredo, Lambert, Jean-Charles, van der Lee, Sven J., Ruiz, Agustín, Smith, A David, Saenz, Aldo, Bizzarro, Alessandra, Lauria, Alessandra, Vacca, Alessandro, Solomon, Alina, Anastasiou, Anna, Richardson, Anna, Boland, Anne, Koivisto, Anne, Daniele, Antonio, Greco, Antonio, Marianthi, Arnaoutoglou, McGuinness, Bernadette, Fin, Bertrand, Ferrari, Camilla, Custodero, Carlo, Ferrarese, Carlo, Ingino, Carlos, Mangone, Carlos, Reyes Toso, Carlos, Martínez, Carmen, Cuesta, Carolina, Muchnik, Carolina, Joachim, Catharine, Ortiz, Cecilia, Besse, Céline, Johansson, Charlotte, Zoia, Chiara Paola, Laske, Christoph, Anastasiou, Costas, Palacio, Dana Lis, Politis, Daniel G, Janowitz, Daniel, Craig, David, Mann, David M, Neary, David, Jürgen, Deckert, Daian, Delphine, Belezhanska, Diyana, Kohler, Eduardo, Castaño, Eduardo M, Koutsouraki, Effrosyni, Chipi, Elena, De Roeck, Ellen, Costantini, Emanuele, Vardy, Emma R L C, Piras, Fabrizio, Roveta, Fausto, Piras, Federica, Prestia, Federico Ariel, Assogna, Francesca, Salani, Francesca, Sala, Gessica, Lacidogna, Giordano, Novack, Gisela, Wilcock, Gordon, Thonberg, Håkan, Kölsch, Heike, Weber, Heike, Boecker, Henning, Etchepareborda, Ignacio, Piaceri, Irene, Tuomilehto, Jaakko, Lindström, Jaana, Laczo, Jan, Johnston, Janet, Deleuze, Jean-François, Harris, Jenny, Schott, Jonathan M, Priller, Josef, Bacha, Juan Ignacio, Snowden, Julie, Lisso, Julieta, Mihova, Kalina Yonkova, Traykov, Latchezar, Morelli, Laura, Brusco, Luis Ignacio, Rainer, Malik, Takalo, Mari, Bjerke, Maria, Del Zompo, Maria, Serpente, Maria, Sanchez Abalos, Mariana, Rios, Mario, Peltonen, Markku, Herrman, Martin J, Kohler, Matias, Rojo, Matias, Jones, Matthew, Orsini, Michela, Medel, Nancy, Olivar, Natividad, Fox, Nick C, Salvadori, Nicola, Hooper, Nigel M, Galeano, Pablo, Solis, Patricia, Bastiani, Patrizia, Passmore, Peter, Heun, Reinhard, Antikainen, Riitta, Olaso, Robert, Perneczky, Robert, Germani, Sandra, López-García, Sara, Love, Seth, Mehrabian, Shima, Bagnoli, Silvia, Kochen, Silvia, Andreoni, Simona, Teipel, Stefan, Todd, Stephen, Pickering-Brown, Stuart, Natunen, Teemu, Tegos, Thomas, Laatikainen, Tiina, Strandberg, Timo, Polvikoski, Tuomo M, Matoska, Vaclav, Ciullo, Valentina, Cores, Valeria, Solfrizzi, Vincenzo, Lisetti, Viviana, Sevillano, Zulma, Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., Corbatón-Anchuelo, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García-González, P., Gil, S., Guitart, M., González-Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M. T., Marquié, M., Mauleón, A., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejá, E., Pérez-Cordon, A., Pineda, J. A., Preckler, S., Quintela, I., Real, L. M., Rosende-Roca, M., Ruiz, A., Sáez, M. E., Sanabria, A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A. D., Alarcón-Martín, E., Alonso, M. D., Álvarez, I., Álvarez, V., Amer-Ferrer, G., Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Buiza-Rueda, D., Bullido, M. J., Burguera, J. A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M. J., Clarimón, J., Cruz-Gamero, J. M., de Pancorbo, M. M., Del Ser, T., Diez-Fairen, M., Escuela, R., Garrote-Espina, L., Fortea, J., Franco-Macías, E., Frank-García, A., García-Alberca, J. M., Garcia Madrona, S., Garcia-Ribas, G., Gómez-Garre, P., Hevilla, S., Jesús, S., Labrador Espinosa, M. A., Lage, C., Legaz, A., Lleó, A., Lopez de Munain, A., López-García, S., Macias-García, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J. L., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Pineda-Sanchez, R., Piñol-Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J. L., Sanchez Del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M. P., Vigo-Ortega, R., Vivancos, L., Macleod, C., McCracken, C., Brayne, Carol, Bresner, Catherine, Grozeva, Detelina, Bellou, Eftychia, Sommerville, Ewen W, Matthews, F., Leonenko, Ganna, Menzies, Georgina, Windle, Gill, Harwood, Janet, Phillips, Judith, Bennett, K., Luckuck, Lauren, Clare, Linda, Woods, Robert, Saad, Salha, Burholt, Vanessa, Rongve, Arvid, Brussels Heritage Lab, Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
polygenic risk scores, Multidisciplinary, Common variants, Neuroscience(all), neurology, Medizin, General Physics and Astronomy, ddc:500, General Chemistry, Alzheimer's disease, General Biochemistry, Genetics and Molecular Biology, RISK STRATIFICATION
Abstract

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was updated to add “P.M” between “P.D.” and “R.C.”. Additionally, the original version of this Article contained the incorrect affiliation for author Patrick Gavin Kehoe, which incorrectly read “German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany”. The correct version replaces this affiliation with “Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK”. This has been corrected in both the PDF and HTML versions of the Article. CA extern

Published
2023

54. Response to “Comment on ‘Dementia prevention: The potential long‐term cost‐effectiveness of the FINGER prevention program’”

Author

Wimo, Anders, primary, Handels, Ron, additional, Antikainen, Riitta, additional, Eriksdotter, Maria, additional, Jönsson, Linus, additional, Knapp, Martin, additional, Kulmala, Jenni, additional, Laatikainen, Tiina, additional, Lehtisalo, Jenni, additional, Peltonen, Markku, additional, Sköldunger, Anders, additional, Soininen, Hilkka, additional, Solomon, Alina, additional, Strandberg T, Timo, additional, Tuomilehto, Jaakko, additional, Ngandu, Tiia, additional, and Kivipelto, Miia, additional

Published
2023
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55. The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Author

Rydström, Anders, primary, Stephen, Ruth, additional, Kåreholt, Ingemar, additional, Darin Mattsson, Alexander, additional, Ngandu, Tiia, additional, Lehtisalo, Jenni, additional, Bäckman, Lars, additional, Kemppainen, Nina, additional, Rinne, Juha, additional, Sindi, Shireen, additional, Soininen, Hilkka, additional, Vanninen, Ritva, additional, Solomon, Alina, additional, and Mangialasche, Francesca, additional

Published
2023
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56. Dementia prevention in memory clinics: recommendations from the European task force for brain health services

Author

Frisoni, Giovanni B., primary, Altomare, Daniele, additional, Ribaldi, Federica, additional, Villain, Nicolas, additional, Brayne, Carol, additional, Mukadam, Naaheed, additional, Abramowicz, Marc, additional, Barkhof, Frederik, additional, Berthier, Marcelo, additional, Bieler-Aeschlimann, Melanie, additional, Blennow, Kaj, additional, Brioschi Guevara, Andrea, additional, Carrera, Emmanuel, additional, Chételat, Gaël, additional, Csajka, Chantal, additional, Demonet, Jean-François, additional, Dodich, Alessandra, additional, Garibotto, Valentina, additional, Georges, Jean, additional, Hurst, Samia, additional, Jessen, Frank, additional, Kivipelto, Miia, additional, Llewellyn, David J., additional, McWhirter, Laura, additional, Milne, Richard, additional, Minguillón, Carolina, additional, Miniussi, Carlo, additional, Molinuevo, José Luis, additional, Nilsson, Peter M., additional, Noyce, Alastair, additional, Ranson, Janice M., additional, Grau-Rivera, Oriol, additional, Schott, Jonathan M., additional, Solomon, Alina, additional, Stephen, Ruth, additional, van der Flier, Wiesje, additional, van Duijn, Cornelia, additional, Vellas, Bruno, additional, Visser, Leonie N.C., additional, Cummings, Jeffrey L., additional, Scheltens, Philip, additional, Ritchie, Craig, additional, and Dubois, Bruno, additional

Published
2023
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57. The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia

Author

Rydström, Anders, Stephen, Ruth, Kåreholt, Ingemar, Mattsson, Alexander Darin, Ngandu, Tiia, Lehtisalo, Jenni, Bäckman, Lars, Kemppainen, Nina, Rinne, Juha, Sindi, Shireen, Soininen, Hilkka, Vanninen, Ritva, Solomon, Alina, Mangialasche, Francesca, Rydström, Anders, Stephen, Ruth, Kåreholt, Ingemar, Mattsson, Alexander Darin, Ngandu, Tiia, Lehtisalo, Jenni, Bäckman, Lars, Kemppainen, Nina, Rinne, Juha, Sindi, Shireen, Soininen, Hilkka, Vanninen, Ritva, Solomon, Alina, and Mangialasche, Francesca

Abstract

Introduction: Mechanisms underlying the positive association between occupational mental demands and late-life cognition are poorly understood. The objective of this study was to assess whether the association between occupational complexity and cognition is related to and moderated by brain integrity in individuals at-risk for dementia. Brain integrity was appraised throughout structural measures (Magnetic Resonance Imaging, MRI) and amyloid accumulation (Pittsburgh Compound B (PiB)-positron emission tomography, PiB-PET). Methods: Participants from the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) neuroimaging sample -MRI (N=126), PiB-PET (N=41)- were included in a post-hoc cross-sectional analysis. Neuroimaging parameters comprised the Alzheimer´s Disease signature cortical thickness (ADS, Freesurfer 5.3), medial temporal atrophy (MTA), and amyloid accumulation (PiB-PET). Cognition was assessed using the Neuropsychological Test Battery. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Linear regression models included cognition as dependent variable, occupational complexity, measures of brain integrity, and their interaction terms as predictors. Results: Occupational complexity with data and substantive complexity were associated with better cognition (overall cognition, executive function) when adjusting for ADS and MTA (independent association). Significant interaction effects between occupational complexity and brain integrity were also found, indicating that, for some indicators of brain integrity and cognition (e.g., overall cognition, processing speed), the positive association between occupational complexity and cognition occurred only among persons with higher brain integrity (moderated association). Conclusion: Among individuals at-risk for dementia, occupational complexity does not seem to contribute towards resilience agains

Published
2023
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58. Dementia prevention in memory clinics:recommendations from the European task force for brain health services

Author

Frisoni, Giovanni B., Altomare, Daniele, Ribaldi, Federica, Villain, Nicolas, Brayne, Carol, Mukadam, Naaheed, Abramowicz, Marc, Barkhof, Frederik, Berthier, Marcelo, Bieler-Aeschlimann, Melanie, Blennow, Kaj, Brioschi Guevara, Andrea, Carrera, Emmanuel, Chételat, Gaël, Csajka, Chantal, Demonet, Jean François, Dodich, Alessandra, Garibotto, Valentina, Georges, Jean, Hurst, Samia, Jessen, Frank, Kivipelto, Miia, Llewellyn, David J., McWhirter, Laura, Milne, Richard, Minguillón, Carolina, Miniussi, Carlo, Molinuevo, José Luis, Nilsson, Peter M., Noyce, Alastair, Ranson, Janice M., Grau-Rivera, Oriol, Schott, Jonathan M., Solomon, Alina, Stephen, Ruth, van der Flier, Wiesje, van Duijn, Cornelia, Vellas, Bruno, Visser, Leonie N.C., Cummings, Jeffrey L., Scheltens, Philip, Ritchie, Craig, Dubois, Bruno, Frisoni, Giovanni B., Altomare, Daniele, Ribaldi, Federica, Villain, Nicolas, Brayne, Carol, Mukadam, Naaheed, Abramowicz, Marc, Barkhof, Frederik, Berthier, Marcelo, Bieler-Aeschlimann, Melanie, Blennow, Kaj, Brioschi Guevara, Andrea, Carrera, Emmanuel, Chételat, Gaël, Csajka, Chantal, Demonet, Jean François, Dodich, Alessandra, Garibotto, Valentina, Georges, Jean, Hurst, Samia, Jessen, Frank, Kivipelto, Miia, Llewellyn, David J., McWhirter, Laura, Milne, Richard, Minguillón, Carolina, Miniussi, Carlo, Molinuevo, José Luis, Nilsson, Peter M., Noyce, Alastair, Ranson, Janice M., Grau-Rivera, Oriol, Schott, Jonathan M., Solomon, Alina, Stephen, Ruth, van der Flier, Wiesje, van Duijn, Cornelia, Vellas, Bruno, Visser, Leonie N.C., Cummings, Jeffrey L., Scheltens, Philip, Ritchie, Craig, and Dubois, Bruno

Abstract

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.

Published
2023

61. Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Author

Stephen, Ruth, Liu, Yawu, Ngandu, Tiia, Antikainen, Riitta, Hulkkonen, Juha, Koikkalainen, Juha, Kemppainen, Nina, Lötjönen, Jyrki, Levälahti, Esko, Parkkola, Riitta, Pippola, Pauliina, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Kivipelto, Miia, Soininen, Hilkka, Solomon, Alina, and for the FINGER study group

Published
2019
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62. 27‐hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia‐associated brain white matter changes

Author

Alanko, Vilma, primary, Gaminde‐Blasco, Adhara, additional, Quintela‐López, Tania, additional, Loera‐Valencia, Raúl, additional, Solomon, Alina, additional, Björkhem, Ingemar, additional, Cedazo‐Minguez, Angel, additional, Maioli, Silvia, additional, Tabacaru, Graziella, additional, Latorre‐Leal, María, additional, Matute, Carlos, additional, Kivipelto, Miia, additional, Alberdi, Elena, additional, and Sandebring‐Matton, Anna, additional

Published
2023
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65. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Author

Ngandu, Tiia, Lehtisalo, Jenni, Solomon, Alina, Levälahti, Esko, Ahtiluoto, Satu, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lindström, Jaana, Mangialasche, Francesca, Paajanen, Teemu, Pajala, Satu, Peltonen, Markku, Rauramaa, Rainer, Stigsdotter-Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, and Kivipelto, Miia

Published
2015
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68. Changes in modifiable risk factors for Alzheimer´s disease and dementia during the COVID‐19 pandemic in Swedish older adults: a population‐based digital survey

Author

Rocha, Ana Sabsil Lopez, primary, Mangialasche, Francesca, additional, Thunborg, Charlotta, additional, Levak, Nicholas, additional, Aspö, Malin, additional, Rydström, Anders, additional, Lehtisalo, Jenni, additional, de Jager, Celeste A, additional, Price, Geraint J, additional, Hall, Anette, additional, Solomon, Alina, additional, Ngandu, Tiia, additional, and Kivipelto, Miia, additional

Published
2022
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69. From FINGER to MET‐FINGER: metformin and lifestyle intervention for multimodal precision prevention of dementia

Author

Kivipelto, Miia, primary, Barbera, Mariagnese, additional, de Jager, Celeste A, additional, Lehtisalo, Jenni, additional, Levak, Nicholas, additional, Middleton, Lefkos T, additional, Price, Geraint J, additional, Rydström, Anders, additional, Thunborg, Charlotta, additional, Mangialasche, Francesca, additional, Ngandu, Tiia, additional, and Solomon, Alina, additional

Published
2022
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71. Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease

Author

Dehghan, Abbas, primary, Pinto, Rui Climaco, additional, Karaman, Ibrahim, additional, Huang, Jian, additional, Durainayagam, Brenan R., additional, Ghanbari, Mohsen, additional, Nazeer, Areesha, additional, Zhong, Qi, additional, Liggi, Sonia, additional, Whiley, Luke, additional, Mustafa, Rima, additional, Kivipelto, Miia, additional, Solomon, Alina, additional, Ngandu, Tiia, additional, Kanekiyo, Takahisa, additional, Aikawa, Tomonori, additional, Radulescu, Carola I., additional, Barnes, Samuel J., additional, Graça, Gonçalo, additional, Chekmeneva, Elena, additional, Camuzeaux, Stephane, additional, Lewis, Matthew R., additional, Kaluarachchi, Manuja R., additional, Ikram, M. Arfan, additional, Holmes, Elaine, additional, Tzoulaki, Ioanna, additional, Matthews, Paul M., additional, Griffin, Julian L., additional, and Elliott, Paul, additional

Published
2022
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72. β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population

Author

Rosenberg, Anna, primary, Öhlund-Wistbacka, Ulf, additional, Hall, Anette, additional, Bonnard, Alexandre, additional, Hagman, Göran, additional, Rydén, Marie, additional, Thunborg, Charlotta, additional, Wiggenraad, Fleur, additional, Sandebring-Matton, Anna, additional, Solomon, Alina, additional, and Kivipelto, Miia, additional

Published
2022
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77. Precision medicine in neurodegeneration: the IHI-PROMINENT project.

Author

Tate, Ashley, Suárez-Calvet, Marc, Ekelund, Mats, Eriksson, Sven, Eriksdotter, Maria, Van Der Flier, Wiesje M., Georges, Jean, Kivipelto, Miia, Kramberger, Milica G., Lindgren, Peter, Gispert López, Juan Domingo, Lötjönen, Jyrki, Persson, Sofie, Pla, Sandra, Solomon, Alina, Thurfjell, Lennart, Wimo, Anders, Winblad, Bengt, and Jönsson, Linus

Subjects
INDIVIDUALIZED medicine, ALZHEIMER'S disease, DIGITAL technology, CLINICAL decision support systems, NEURODEGENERATION
Abstract

Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Recent advances in diagnostics and approval for new pharmaceutical treatments for Alzheimer's disease (AD), the most common etiology of dementia, heralds the beginning of precision medicine in this field. However, their implementation will challenge an already over-burdened healthcare systems. There is a need for innovative digital solutions that can drive the related clinical pathways and optimize and personalize care delivery. Public-private partnerships are ideal vehicles to tackle these challenges. Here we describe the Innovative Health Initiative (IHI) public-private partnership project PROMINENT that has been initiated by connecting leading dementia researchers, medical professionals, dementia patients and their care partners with the latest innovative health technologies using a precision medicine based digital platform. The project builds upon the knowledge and already implemented digital tools from several collaborative initiatives that address new models for early detection, diagnosis, and monitoring of AD and other neurodegenerative disorders. The project aims to provide support to improvement efforts to each aspect of the care pathway including diagnosis, prognosis, treatment, and data collection for real world evidence and cost effectiveness studies. Ultimately the PROMINENT project is expected to lead to cost-effective care and improved health outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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79. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

Author

Soininen, Hilkka, Solomon, Alina, Visser, Pieter Jelle, Hendrix, Suzanne B., Blennow, Kaj, Kivipelto, Miia, Hartmann, Tobias, Hallikainen, Ilona, Hallikainen, Merja, Helisalmi, Seppo, Lappalainen, Tarja, Liu, Yawu, Paajanen, Teemu, Wahlund, Lars-Olof, Freund-Levi, Yvonne, Andreasen, Niels, Hagman, Göran, Lindblom, Stina, Fassbender, Klaus, Riemenschneider, Matthias, Grimm, Marcus O. W., Klees-Rollmann, Aline, Luley, Maxine, Lyros, Epameinondas, Schomburg, Robert, Kennel, Jennifer, Ramelli, Daniela, Frölich, Lutz, Hausner, Lucrezia, Laske, Christoph, Leyhe, Thomas, Mychajliw, Christian, Koehler, Niklas, Schiekofer, Stephan, Klünemann, Hans, Schröder, Johannes, Lütjohann, Dieter, Scheltens, Philip, Van Rossum, Ineke, Scheltens, Nienke, Bertens, Daniela, Ten Kate, Mara, Barkhof, Frederik, Henselmans, Johanna M. L., Roks, Gerwin, Van Hees, Anneke M. J., and Ellison, Noel

Published
2022
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80. Dementia prevention: The potential long‐term cost‐effectiveness of the FINGER prevention program

Author

Wimo, Anders, primary, Handels, Ron, additional, Antikainen, Riitta, additional, Eriksdotter, Maria, additional, Jönsson, Linus, additional, Knapp, Martin, additional, Kulmala, Jenni, additional, Laatikainen, Tiina, additional, Lehtisalo, Jenni, additional, Peltonen, Markku, additional, Sköldunger, Anders, additional, Soininen, Hilkka, additional, Solomon, Alina, additional, Strandberg, Timo, additional, Tuomilehto, Jaakko, additional, Ngandu, Tiia, additional, and Kivipelto, Miia, additional

Published
2022
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81. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress

Author

Kivipelto, Miia, Solomon, Alina, Ahtiluoto, Satu, Ngandu, Tiia, Lehtisalo, Jenni, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lindström, Jaana, Mangialasche, Francesca, Nissinen, Aulikki, Paajanen, Teemu, Pajala, Satu, Peltonen, Markku, Rauramaa, Rainer, Stigsdotter-Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, and Soininen, Hilkka

Published
2013
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83. Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer’s disease: a potential early sign of AD

Author

Fisiología, Fisiologia, Goikolea, Julen, Gereñu Lopetegi, Gorka, Daniilidou, Makrina, Mangialasche, Francesca, Mecocci, Patrizia, Ngandu, Tiia, Rinne, Juha, Solomon, Alina, Kivipelto, Miia, Cedazo Mínguez, Ángel, Sandebring-Matton, Anna, Maioli, Silvia, Fisiología, Fisiologia, Goikolea, Julen, Gereñu Lopetegi, Gorka, Daniilidou, Makrina, Mangialasche, Francesca, Mecocci, Patrizia, Ngandu, Tiia, Rinne, Juha, Solomon, Alina, Kivipelto, Miia, Cedazo Mínguez, Ángel, Sandebring-Matton, Anna, and Maioli, Silvia

Abstract

[EN] Background: Thioredoxin-80 (Trx80) is a cleavage product from the redox-active protein Thioredoxin-1 and has been previously described as a pro-inflammatory cytokine secreted by immune cells. Previous studies in our group reported that Trx80 levels are depleted in Alzheimer's disease (AD) brains. However, no studies so far have investigated peripheral Trx80 levels in the context of AD pathology and whether could be associated with the main known AD risk factors and biomarkers. Methods: Trx80 was measured in serum samples from participants from two different cohorts: the observational memory clinic biobank (GEDOC) (N = 99) with AD CSF biomarker data was available and the population-based lifestyle multidomain intervention trial Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (N = 47), with neuroimaging data and blood markers of inflammation available. The GEDOC cohort consists of participants diagnosed with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and AD, whereas the FINGER participants are older adults at-risk of dementia, but without substantial cognitive impairment. One-way ANOVA and multiple comparison tests were used to assess the levels of Trx80 between groups. Linear regression models were used to explore associations of Trx80 with cognition, AD CSF biomarkers (A beta 42, t-tau, p-tau and p-tau/t-tau ratio), inflammatory cytokines, and neuroimaging markers. Results: In the GEDOC cohort, Trx80 was associated to p-tau/t-tau ratio in the MCI group. In the FINGER cohort, serum Trx80 levels correlated with lower hippocampal volume and higher pro-inflammatory cytokine levels. In both GEDOC and FINGER cohorts, ApoE4 carriers had significantly higher serum Trx80 levels compared to non-ApoE4 carriers. However, Trx80 levels in the brain were further decreased in AD patients with ApoE4 genotype. Conclusion: We report that serum Trx80 levels are associated to AD disease stage as well as to se

Published
2022

84. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Author

Ngandu, Tiia, Lehtisalo, Jenni, Korkki, Saana, Solomon, Alina, Coley, Nicola, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Lindstrom, Jaana, Laatikainen, Tiina, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia, Ngandu, Tiia, Lehtisalo, Jenni, Korkki, Saana, Solomon, Alina, Coley, Nicola, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Lindstrom, Jaana, Laatikainen, Tiina, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, and Kivipelto, Miia

Abstract

Introduction Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses). Methods FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores. Results Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function. Discussion Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.

Published
2022
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85. Occupational complexity and cognition in the FINGER multidomain intervention trial

Author

Rydström, Anders, Darin-Mattsson, Alexander, Kåreholt, Ingemar, Ngandu, Tiia, Lehtisalo, Jenni, Solomon, Alina, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Laatikainen, Tiina, Levälahti, Esko, Lindström, Jaana, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Sindi, Shireen, Soininen, Hilkka, Neely, Anna Stigsdotter, Strandberg, Timo, Tuomilehto, Jaakko, Kivipelto, Miia, Mangialasche, Francesca, Rydström, Anders, Darin-Mattsson, Alexander, Kåreholt, Ingemar, Ngandu, Tiia, Lehtisalo, Jenni, Solomon, Alina, Antikainen, Riitta, Bäckman, Lars, Hänninen, Tuomo, Laatikainen, Tiina, Levälahti, Esko, Lindström, Jaana, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Sindi, Shireen, Soininen, Hilkka, Neely, Anna Stigsdotter, Strandberg, Timo, Tuomilehto, Jaakko, Kivipelto, Miia, and Mangialasche, Francesca

Abstract

Introduction: Lifetime exposure to occupational complexity is linked to late-life cognition, and may affect benefits of preventive interventions. Methods: In the 2-year multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), we investigated, through post hoc analyses (N = 1026), the association of occupational complexity with cognition. Occupational complexity with data, people, and substantive complexity were classified through the Dictionary of Occupational Titles. Results: Higher levels of occupational complexity were associated with better baseline cognition. Measures of occupational complexity had no association with intervention effects on cognition, except for occupational complexity with data, which was associated with the degree of intervention-related gains for executive function. Discussion: In older adults at increased risk for dementia, higher occupational complexity is associated with better cognition. The cognitive benefit of the FINGER intervention did not vary significantly among participants with different levels of occupational complexity. These exploratory findings require further testing in larger studies.

Published
2022
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86. Cortisol, cognition and Alzheimer's disease biomarkers among memory clinic patients

Author

Holleman, Jasper, Adagunodo, Sofia, Kåreholt, Ingemar, Hagman, Goran, Aspo, Malin, Udeh-Momoh, Chinedu T., Solomon, Alina, Kivipelto, Miia, Sindi, Shireen, Holleman, Jasper, Adagunodo, Sofia, Kåreholt, Ingemar, Hagman, Goran, Aspo, Malin, Udeh-Momoh, Chinedu T., Solomon, Alina, Kivipelto, Miia, and Sindi, Shireen

Abstract

Objective This study aims to investigate the relationship between diurnal cortisol patterns, cognition and Alzheimer's disease (AD) biomarkers in memory clinic patients. Method Memory clinic patients were recruited from Karolinska University Hospital in Sweden (n=155). Diurnal cortisol patterns were assessed using five measures: awakening levels, cortisol awakening response, bedtime levels, the ratio of awakening to bedtime levels (AM/PM ratio) and total daily output. Cognition was measured in five domains: memory, working memory, processing speed, perceptual reasoning and overall cognition. AD biomarkers A beta(42), total tau and phosphorylated tau were assessed from cerebrospinal fluid (CSF). Cognition was measured at follow-up (average 32 months) in a subsample of participants (n=57). Results In assessing the associations between cortisol and cognition, higher awakening cortisol levels were associated with greater processing speed at baseline. No relationship was found between diurnal cortisol patterns and change in cognition over time or CSF AD biomarkers in the total sample. After stratification by CSF A beta(42) levels, higher awakening cortisol levels were associated with worse memory performance in amyloid-positive participants. In amyloid-negative participants, higher bedtime cortisol levels and a lower AM/PM ratio were associated with lower overall cognition, greater awakening cortisol levels were associated with better processing speed, and a higher AM/PM ratio was associated with better perceptual reasoning. Additionally, higher awakening cortisol levels were associated with lower CSF A beta(42) levels in amyloid-positive participants, while higher bedtime cortisol levels and a lower AM/PM ratio were associated with higher CSF total tau in amyloid-negative participants. Conclusions Our findings suggest that diurnal cortisol patterns are associated with cognitive function and provide new insights into the association between diurnal cortisol patterns and

Published
2022
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87. Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease

Author

Dehghan, Abbas, Pinto, Rui Climaco, Karaman, Ibrahim, Huang, Jian, Durainayagam, Brenan R., Ghanbari, Mohsen, Nazeer, Areesha, Zhong, Qi, Liggi, Sonia, Whiley, Luke, Mustafa, Rima, Kivipelto, Miia, Solomon, Alina, Ngandu, Tiia, Kanekiyo, Takahisa, Aikawa, Tomonori, Radulescu, Carola I., Barnes, Samuel J., Graça, Gonçalo, Chekmeneva, Elena, Camuzeaux, Stephane, Lewis, Matthew R., Kaluarachchi, Manuja R., Ikram, M. Arfan, Holmes, Elaine, Tzoulaki, Ioanna, Matthews, Paul M., Griffin, Julian L., Elliott, Paul, Dehghan, Abbas, Pinto, Rui Climaco, Karaman, Ibrahim, Huang, Jian, Durainayagam, Brenan R., Ghanbari, Mohsen, Nazeer, Areesha, Zhong, Qi, Liggi, Sonia, Whiley, Luke, Mustafa, Rima, Kivipelto, Miia, Solomon, Alina, Ngandu, Tiia, Kanekiyo, Takahisa, Aikawa, Tomonori, Radulescu, Carola I., Barnes, Samuel J., Graça, Gonçalo, Chekmeneva, Elena, Camuzeaux, Stephane, Lewis, Matthew R., Kaluarachchi, Manuja R., Ikram, M. Arfan, Holmes, Elaine, Tzoulaki, Ioanna, Matthews, Paul M., Griffin, Julian L., and Elliott, Paul

Abstract

Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (MWAS) of AD-associated loci from GWASs using untargeted metabolic profiling (metabolomics) by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). We identified an association of lactosylceramides (LacCer) with AD-related single-nucleotide polymorphisms (SNPs) in ABCA7 (P = 5.0 × 10-5 to 1.3 × 10-44). We showed that plasma LacCer concentrations are associated with cognitive performance and genetically modified levels of LacCer are associated with AD risk. We then showed that concentrations of sphingomyelins, ceramides, and hexosylceramides were altered in brain tissue from Abca7 knockout mice, compared with wild type (WT) (P = 0.049-1.4 × 10-5), but not in a mouse model of amyloidosis. Furthermore, activation of microglia increases intracellular concentrations of hexosylceramides in part through induction in the expression of sphingosine kinase, an enzyme with a high control coefficient for sphingolipid and ceramide synthesis. Our work suggests that the risk for AD arising from functional variations in ABCA7 is mediated at least in part through ceramides. Modulation of their metabolism or downstream signaling may offer new therapeutic opportunities for AD.

Published
2022

89. Dementia prevention: The potential long‐term cost‐effectiveness of the FINGER prevention program.

Author

Wimo, Anders, Handels, Ron, Antikainen, Riitta, Eriksdotter, Maria, Jönsson, Linus, Knapp, Martin, Kulmala, Jenni, Laatikainen, Tiina, Lehtisalo, Jenni, Peltonen, Markku, Sköldunger, Anders, Soininen, Hilkka, Solomon, Alina, Strandberg, Timo, Tuomilehto, Jaakko, Ngandu, Tiia, and Kivipelto, Miia

Abstract

Introduction: The aim of this study was to estimate the potential cost‐effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program. Methods: A life‐time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program. Results: Costs were 1,653,275 and 1,635,346 SEK and quality‐adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person‐years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios. Discussion: The model provides support that programs like FINGER have the potential to be cost‐effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population. [ABSTRACT FROM AUTHOR]

Published
2023
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91. Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial

Author

Neuvonen, Elisa, primary, Lehtisalo, Jenni, additional, Ngandu, Tiia, additional, Levälahti, Esko, additional, Antikainen, Riitta, additional, Hänninen, Tuomo, additional, Laatikainen, Tiina, additional, Lindström, Jaana, additional, Paajanen, Teemu, additional, Soininen, Hilkka, additional, Strandberg, Timo, additional, Tuomilehto, Jaakko, additional, Kivipelto, Miia, additional, and Solomon, Alina, additional

Published
2022
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92. Additional file 1 of Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer���s disease: a potential early sign of AD

Author

Goikolea, Julen, Gerenu, Gorka, Daniilidou, Makrina, Mangialasche, Francesca, Mecocci, Patrizia, Ngandu, Tiia, Rinne, Juha, Solomon, Alina, Kivipelto, Miia, Cedazo-Minguez, Angel, Sandebring-Matton, Anna, and Maioli, Silvia

Abstract

Additional file 1: Supplementary Table 1. Demographic and clinical data from the human brain tissue samples.

Published
2022
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93. Multidomain interventions:state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6

Author

Solomon, Alina, Stephen, Ruth, Altomare, Daniele, Carrera, Emmanuel, Frisoni, Giovanni B., Kulmala, Jenni, Molinuevo, José Luis, Nilsson, Peter, Ngandu, Tiia, Ribaldi, Federica, Vellas, Bruno, Scheltens, Philip, Kivipelto, Miia, Abramowicz, Marc, Barkhof, Frederik, Berthier, Marcelo, Bieler, Melanie, Blennow, Kaj, Brayne, Carol, Brioschi, Andrea, Chételat, Gael, Csajka, Chantal, Demonet, Jean-François, Dodich, Alessandra, Dubois, Bruno, Garibotto, Valentina, Georges, Jean, Hurst, Samia, Jessen, Frank, Llewellyn, David, Mcwhirter, Laura, Milne, Richard, Minguillón, Carolina, Miniussi, Carlo, Nilsson, Peter M., Ranson, Janice, Ritchie, Craig, van Duijn, Cornelia, van der Flier, Wiesje, and Visser, Leonie

Subjects
Gerontology, Aging, Cognitive Neuroscience, MEDLINE, Psychological intervention, Brain Health Services, Neurosciences. Biological psychiatry. Neuropsychiatry, Review, Prevention of dementia, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Dementia risk, Dementia, Humans, Cognitive Dysfunction, 030212 general & internal medicine, Cognitive decline, RC346-429, business.industry, Prevention, Brain, Cognition, Alzheimer’s disease, Risk reduction, Health Services, Risk Reduction Behavior, medicine.disease, 3. Good health, Neurology, Neurology (clinical), Neurology. Diseases of the nervous system, business, 030217 neurology & neurosurgery, Geriatric psychiatry, RC321-571
Abstract

Although prevention of dementia and late-life cognitive decline is a major public health priority, there are currently no generally established prevention strategies or operational models for implementing such strategies into practice. This article is a narrative review of available evidence from multidomain dementia prevention trials targeting several risk factors and disease mechanisms simultaneously, in individuals without dementia at baseline. Based on the findings, we formulate recommendations for implementing precision risk reduction strategies into new services called Brain Health Services. A literature search was conducted using medical databases (MEDLINE via PubMed and SCOPUS) to select relevant studies: non-pharmacological multidomain interventions (i.e., combining two or more intervention domains), target population including individuals without dementia, and primary outcomes including cognitive/functional performance changes and/or incident cognitive impairment or dementia. Further literature searches covered the following topics: sub-group analyses assessing potential modifiers for the intervention effect on cognition in the multidomain prevention trials, dementia risk scores used as surrogate outcomes in multidomain prevention trials, dementia risk scores in relation to brain pathology markers, and cardiovascular risk scores in relation to dementia. Multidomain intervention studies conducted so far appear to have mixed results and substantial variability in target populations, format and intensity of interventions, choice of control conditions, and outcome measures. Most trials were conducted in high-income countries. The differences in design between the larger, longer-term trials that met vs. did not meet their primary outcomes suggest that multidomain intervention effectiveness may be dependent on a precision prevention approach, i.e., successfully identifying the at-risk groups who are most likely to benefit. One such successful trial has already developed an operational model for implementing the intervention into practice. Evidence on the efficacy of risk reduction interventions is promising, but not yet conclusive. More long-term multidomain randomized controlled trials are needed to fill the current evidence gaps, especially concerning low- and middle-income countries and integration of dementia prevention with existing cerebrovascular prevention programs. A precision risk reduction approach may be most effective for dementia prevention. Such an approach could be implemented in Brain Health Services.

Published
2021

94. Occupational complexity and cognition in the FINGER multidomain intervention trial

Author

Rydström, Anders, primary, Darin‐Mattsson, Alexander, additional, Kåreholt, Ingemar, additional, Ngandu, Tiia, additional, Lehtisalo, Jenni, additional, Solomon, Alina, additional, Antikainen, Riitta, additional, Bäckman, Lars, additional, Hänninen, Tuomo, additional, Laatikainen, Tiina, additional, Levälahti, Esko, additional, Lindström, Jaana, additional, Paajanen, Teemu, additional, Havulinna, Satu, additional, Peltonen, Markku, additional, Sindi, Shireen, additional, Soininen, Hilkka, additional, Neely, Anna Stigsdotter, additional, Strandberg, Timo, additional, Tuomilehto, Jaakko, additional, Kivipelto, Miia, additional, and Mangialasche, Francesca, additional

Published
2022
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100. Lifestyle and behavior changes during the COVID19 pandemic in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Author

Lehtisalo, Jenni, primary, Ngandu, Tiia, additional, Mangialasche, Francesca, additional, Hemiö, Katri, additional, Solomon, Alina, additional, Laatikainen, Tiina, additional, Strandberg, Timo, additional, Antikainen, Riitta L, additional, Tuomilehto, Jaakko, additional, Soininen, Hilkka, additional, and Kivipelto, Miia, additional

Published
2021
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