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51. The clinical, histologic, and ultrastructural presentation of polyvinyl sponge (Ivalon) breast prostheses removed for massive fluid accumulation

Author

Garrison Jl, Dominic S. Raso, Greene Wb, and Smith Ar

Subjects
Breast prostheses, medicine.medical_specialty, Pathology, Breast Implants, Periprosthetic, Polyvinyl alcohol, chemistry.chemical_compound, Breast Diseases, Fibrosis, medicine, Humans, Fluid accumulation, Breast, Aged, business.industry, Foreign-Body Reaction, Capsule, Exudates and Transudates, medicine.disease, Surgery, chemistry, Ultrastructure, Female, Polyvinyls, business, Polyvinyl sponge
Abstract

The current study describes what we believe is the first report of bilateral massive seromas associated with open-cell Ivalon sponges. Additionally, the gross, histologic, and ultrastructural features consistent with previous reports of polyvinyl alcohol prostheses are presented. Despite the reported chemical inertness of polyvinyl alcohol, this material may incite a biologic response in some patients, leading to dense fibrosis and occasional foreign-body giant-cell reaction. It is postulated that the molecular breakdown products of the polyvinyl alcohol polymer may create an osmotic gradient across the periprosthetic capsule, which may lead to intracapsular fluid accumulation, as presented in this case.

Published
1999

52. Muon-induced backgrounds in the CUORICINO experiment

Author

Andreotti, E, Arnaboldi, C, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Bloxham, T, Brofferio, C, Bryant, A, Bucci, C, Canonica, L, Capelli, S, Carbone, L, Carrettoni, M, Clemenza, M, Cremonesi, O, Creswick, R, Di Domizio, S, Dolinski, M, Ejzak, L, Faccini, R, Farach, H, Ferri, E, Ferroni, F, Fiorini, E, Foggetta, L, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Kadel, K, Kazkaz, K, Kogler, L, Kolomensky, Y, Kraft, S, Maiano, C, Martinez, C, Martinez, M, Maruyama, R, Mizouni, L, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Orio, F, Pallavicini, M, Palmieri, E, Pattavina, L, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Rusconi, C, Salvioni, C, Sangiorgio, S, Schaeffer, D, Scielzo, N, Sisti, M, Smith, A, Tomei, C, Ventura, G, Vignati, M, Avignone III, FT, BROFFERIO, CHIARA, CAPELLI, SILVIA, CARRETTONI, MARCO ANDREA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Dolinski, MJ, Farach, HA, FERRI, ELENA, FIORINI, ETTORE, GIACHERO, ANDREA, GIRONI, LUCA, Gutierrez, TD, Haller, EE, MAIANO, CECILIA GIOVANNA, Morganti,S, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PATTAVINA, LUCA MARIA, PAVAN, MAURA, SISTI, MONICA, Smith, AR, Vignati, M., Andreotti, E, Arnaboldi, C, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Bloxham, T, Brofferio, C, Bryant, A, Bucci, C, Canonica, L, Capelli, S, Carbone, L, Carrettoni, M, Clemenza, M, Cremonesi, O, Creswick, R, Di Domizio, S, Dolinski, M, Ejzak, L, Faccini, R, Farach, H, Ferri, E, Ferroni, F, Fiorini, E, Foggetta, L, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Kadel, K, Kazkaz, K, Kogler, L, Kolomensky, Y, Kraft, S, Maiano, C, Martinez, C, Martinez, M, Maruyama, R, Mizouni, L, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Orio, F, Pallavicini, M, Palmieri, E, Pattavina, L, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Rusconi, C, Salvioni, C, Sangiorgio, S, Schaeffer, D, Scielzo, N, Sisti, M, Smith, A, Tomei, C, Ventura, G, Vignati, M, Avignone III, FT, BROFFERIO, CHIARA, CAPELLI, SILVIA, CARRETTONI, MARCO ANDREA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Dolinski, MJ, Farach, HA, FERRI, ELENA, FIORINI, ETTORE, GIACHERO, ANDREA, GIRONI, LUCA, Gutierrez, TD, Haller, EE, MAIANO, CECILIA GIOVANNA, Morganti,S, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PATTAVINA, LUCA MARIA, PAVAN, MAURA, SISTI, MONICA, Smith, AR, and Vignati, M.

Abstract

To better understand the contribution of cosmic ray muons to the CUORICINO background, 10 plastic scintillator detectors were installed at the CUORICINO site and operated during the final 3 months of the experiment. From these measurements, an upper limit of 0.0021 counts/(keV kg yr) (95% CL) was obtained on the cosmic ray-induced background in the neutrinoless double beta decay region of interest. The measurements were also compared to GEANT4 simulations.

Published
2010

53. Production of high purity TeO2 single crystals for the study of neutrinoless double beta decay

Author

Arnaboldi, C, Brofferio, C, Bryant, A, Bucci, C, Canonica, L, Capelli, S, Carrettoni, M, Clemenza, M, Dafinei, I, Di Domizio, S, Ferroni, F, Fiorini, E, Ge, Z, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Guardincerri, E, Kadel, K, Kazkaz, K, Kogler, L, Kolomensky, Y, Larsen, J, Laubenstein, M, Li, Y, Maiano, C, Martinez, M, Maruyama, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Orio, F, Pattavina, L, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Rusconi, C, Scielzo, N, Sisti, M, Smith, A, Tian, W, Vignati, M, Wang, H, Zhu, Y, BROFFERIO, CHIARA, CAPELLI, SILVIA, CARRETTONI, MARCO ANDREA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIACHERO, ANDREA, GIRONI, LUCA, MAIANO, CECILIA GIOVANNA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PATTAVINA, LUCA MARIA, PAVAN, MAURA, SISTI, MONICA, Smith, AR, Zhu, Y., Arnaboldi, C, Brofferio, C, Bryant, A, Bucci, C, Canonica, L, Capelli, S, Carrettoni, M, Clemenza, M, Dafinei, I, Di Domizio, S, Ferroni, F, Fiorini, E, Ge, Z, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Guardincerri, E, Kadel, K, Kazkaz, K, Kogler, L, Kolomensky, Y, Larsen, J, Laubenstein, M, Li, Y, Maiano, C, Martinez, M, Maruyama, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Orio, F, Pattavina, L, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Rusconi, C, Scielzo, N, Sisti, M, Smith, A, Tian, W, Vignati, M, Wang, H, Zhu, Y, BROFFERIO, CHIARA, CAPELLI, SILVIA, CARRETTONI, MARCO ANDREA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIACHERO, ANDREA, GIRONI, LUCA, MAIANO, CECILIA GIOVANNA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PATTAVINA, LUCA MARIA, PAVAN, MAURA, SISTI, MONICA, Smith, AR, and Zhu, Y.

Abstract

High purity TeO2 crystals are produced to be used for the search for the neutrinoless double beta decay of 130Te. Dedicated production lines for raw material synthesis, crystal growth, and surface processing were built compliant with radio-purity constraints specific to rare event physics experiments. High sensitivity measurements of radio-isotope concentrations in raw materials, reactants, consumables, ancillaries, and intermediary products used for TeO2 crystals production are reported. Indications are given on the crystals perfection and how it is achieved and maintained in a large scale production process. Production and certification protocols are presented and resulting ready-to-use TeO2 crystals are described. © 2010 Elsevier B.V. All rights reserved.

Published
2010

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Author

Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Clemenza, M, Cremonesi, O, Creswick, R, de Waard, A, Di Domizio, S, Dolinski, M, Farach, H, Fiorini, E, Frossati, G, Giachero, A, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Maruyama, R, Mcdonald, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Vignati, M, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, CREMONESI, OLIVIERO, FIORINI, ETTORE, GIACHERO, ANDREA, GIULIANI, ANDREA, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, PESSINA, GIANLUIGI EZIO, PREVITALI, EZIO, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Maruyama, RH, McDonald, RJ, Norman, EB, Smith, AR, Arnaboldi, C., Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Clemenza, M, Cremonesi, O, Creswick, R, de Waard, A, Di Domizio, S, Dolinski, M, Farach, H, Fiorini, E, Frossati, G, Giachero, A, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Maruyama, R, Mcdonald, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Vignati, M, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, CREMONESI, OLIVIERO, FIORINI, ETTORE, GIACHERO, ANDREA, GIULIANI, ANDREA, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, PESSINA, GIANLUIGI EZIO, PREVITALI, EZIO, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Maruyama, RH, McDonald, RJ, Norman, EB, Smith, AR, and Arnaboldi, C.

Published
2008

55. CUORICINO and CUORE, bolometric experiments for Double Beta Decay Research

Author

Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone FT, I, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Ardito R, Artusa DR, Avignone FT III, Balata M, Bandac I, Barucci M, Beeman, JW, Creswick, RJ, Farach, HA, Gutierrez, TD, Haller, EE, Irastorza, IG, Norman, EB, Smith, AR, Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone FT, I, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Ardito R, Artusa DR, Avignone FT III, Balata M, Bandac I, Barucci M, Beeman, JW, Creswick, RJ, Farach, HA, Gutierrez, TD, Haller, EE, Irastorza, IG, Norman, EB, and Smith, AR

Published
2007

56. CUORICINO and CUORE R&D

Author

Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinsky, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Marujama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quinter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, ZANOTTI, LUIGI ERNESTO, Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinsky, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Marujama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quinter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, and ZANOTTI, LUIGI ERNESTO

Published
2006

57. Cuoricino and CUORE detectors: developing big arrays of large mass bolometers for rare events physics

Author

Gorla, P, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, Dolinski, M, de Waard, A, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Giuliani, A, Guardincerri, E, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Mcdonald, R, Morganti, S, Morales, A, Nisi, S, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, Torres, L, Ventura, G, Xu, N, Artusa, DR, Avignone, FT, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, I. G, McDonald, RJ, Norman, E. B., Smith, AR, Xu, N., BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Gorla, P, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, Dolinski, M, de Waard, A, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Giuliani, A, Guardincerri, E, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Mcdonald, R, Morganti, S, Morales, A, Nisi, S, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, Torres, L, Ventura, G, Xu, N, Artusa, DR, Avignone, FT, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, I. G, McDonald, RJ, Norman, E. B., Smith, AR, Xu, N., BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, and SISTI, MONICA

Abstract

In the last 10 years bolometers have become extremely powerful detectors in the search for rare events, due to their very good resolution. Cuoricino, a 62 bolometer array, in the first months of activity reached a resolution (average in all detectors) in the energy region of interest (2528 keV) of 7 keV and a limit on the t1/2 of the process of 7.5·1023y. Cuoricino’s 62 detectors constitute the biggest number of macrobolometers (790 g each) ever cooled and demonstrate the feasibility of large arrays of bolometers. Following the indication of Cuoricino in CUORE R&D a new detector has been developed trying to improve the reproducibility of the detector’s performance, to increase the single detector mass (to reduce the number of channels) and to simplify the experiment assembly. The latest results are presented.

Published
2006

58. The CUORICINO and CUORE double beta decay experiments

Author

Ardito, R, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, de Waard, A, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Freedman, S, Frossati, G, Gargiulo, C, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Heeger, K, Irastorza, I, Longo, E, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Xu, N, Zanotti, L, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Morganti,S, Norman, EB, PAVAN, MAURA, Smith, AR, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Ardito, R, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, de Waard, A, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Freedman, S, Frossati, G, Gargiulo, C, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Heeger, K, Irastorza, I, Longo, E, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Xu, N, Zanotti, L, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Morganti,S, Norman, EB, PAVAN, MAURA, Smith, AR, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GORLA, PAOLO, NONES, CLAUDIA, NUCCIOTTI, ANGELO ENRICO LODOVICO, SISTI, MONICA, and ZANOTTI, LUIGI ERNESTO

Abstract

After an introduction on the various experimental techniques to be adopted in searches for double beta decay, the new approach based on the use of cryogenic low temperature detectors is described. The present results are reported on the limit for neutrinoless double beta decay of 130Te obtained with the large bolometric detector CUORICINO. This setup consists of 44 cubic crystals of natural TeO2 with 5 cm sides and 18 crystals of 3×3×6 cm3. Four of these latter crystals are made with isotopically enriched materials: two in 128Te and two others in 130Te. With a sensitive mass of 40.7 kg, this array is by far the most massive running cryogenic detector. The array is operated at a temperature of ∼10 mK in a dilution refrigerator under a heavy shield in the Gran Sasso Underground Laboratory at a depth of about 3500 m.w.e. The counting rate in the region of neutrinoless double beta decay is 0.18±0.02 counts keV -1 kg-1 y-1, among the lowest in this type of experiment. No evidence for neutrinoless double beta decay is found. The corresponding lower limit for the lifetime of this process is 2×1024 years at 90% C.L. The resultant upper limit on the effective neutrino mass ranges between 0.2 and 1.0 eV, depending on the theoretically calculated nuclear matrix elements. This constraint is the most restrictive one, except for those obtained with Ge diodes, and is comparable to them. The second part of this report is devoted to the present status of the construction of the larger experiment CUORE (Cryogenic Underground Observatory for Rare Events) formed from 988 bolometers with a cubic TeO2 absorber of size 5×5×5 cm3, with a total mass of ∼750 kg. We present technical details of the CUORE setup as well as of its location and our efforts to reduce radioactive backgrounds. © 2006.

Published
2006

59. New CUORICINO results on the way to CUORE

Author

Gorla, P, Alessandria, F, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, Domizio, S, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Freedman, S, Gargiulo, C, Giachero, A, Guardincerri, E, Giuliani, A, Gutierrez, T, Haller, E, Heeger, K, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Ottonello, P, Pallavicini, M, Palmieri, V, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Vignati, M, Xu, N, Zanotti, L, Artusa, DR, Avignone, FT, Beeman, JW, Creswick, RJ, Domizio, SD, Dolinski, MJ, Farach, HA, Freedman, SJ, Gutierrez, TD, Haller, EE, Irastorza, IG, Norman, EB, Smith, AR, BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIACHERO, ANDREA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Gorla, P, Alessandria, F, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, Domizio, S, Diemoz, M, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Freedman, S, Gargiulo, C, Giachero, A, Guardincerri, E, Giuliani, A, Gutierrez, T, Haller, E, Heeger, K, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Ottonello, P, Pallavicini, M, Palmieri, V, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Vignati, M, Xu, N, Zanotti, L, Artusa, DR, Avignone, FT, Beeman, JW, Creswick, RJ, Domizio, SD, Dolinski, MJ, Farach, HA, Freedman, SJ, Gutierrez, TD, Haller, EE, Irastorza, IG, Norman, EB, Smith, AR, BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, GIACHERO, ANDREA, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, and ZANOTTI, LUIGI ERNESTO

Abstract

CUORE is a 0.75 ton experiment to search for neutrinoless double beta decay of Te130 using 988 TeO2 bolometers. It aims at reaching a sensitivity on the effective neutrino mass of the order of few tens of meV. CUORICINO, a single CUORE tower running since 2003, plays an important role as a stand alone experiment and for developing the future CUORE setup. Present results already achieved and studies that are underway are here presented and discussed.

Published
2006

60. Further developments in the CUORICINO experiment

Author

Pirro, S, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cremonesi, O, Creswick, R, de Waard, A, Dolinski, M, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Maruyama, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, PIRRO, S, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Maruyama, RH, Norman, EB, Smith, AR, Ventura, G., BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Pirro, S, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cremonesi, O, Creswick, R, de Waard, A, Dolinski, M, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Maruyama, R, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, PIRRO, S, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, Maruyama, RH, Norman, EB, Smith, AR, Ventura, G., BROFFERIO, CHIARA, CAPELLI, SILVIA, CLEMENZA, MASSIMILIANO, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, and SISTI, MONICA

Abstract

We report the present results of the CUORICINO experiment, a cryogenic experiment on neutrinoless Double Beta Decay (DBD) of 130Te consisting of an array of 62 TeO2 crystals with a total active mass of 40:7 kg. The array is framed inside a dilution refrigerator, heavily shielded against environmental radioactivity and high-energy neutrons, and it is operated at a temperature of 8mK in the Gran Sasso Underground Laboratory. After several improvements the live time of the experiment is near 75%.

Published
2006

61. New Limit on the Neutrinoless BetaBeta Decay of 130Te

Author

Arnaboldi, C, Artura, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Carbone, L, Capelli, S, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Guardincerri, E, Haller, E, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Artura, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Ventura, G., BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Arnaboldi, C, Artura, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Carbone, L, Capelli, S, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Guardincerri, E, Haller, E, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivieri, E, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, Artura, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Ventura, G., BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, and SISTI, MONICA

Abstract

We report the present results of CUORICINO, a search for neutrinoless double-beta (0ÎÎÎ) decay of Te130. The detector is an array of 62 TeO2 bolometers with a total active mass of 40.7 kg. The array is cooled by a dilution refrigerator shielded from environmental radioactivity and energetic neutrons, operated at â8mK in the Gran Sasso Underground Laboratory. No evidence for (0ÎÎÎ) decay was found and a new lower limit, T1/20Î≥1.8Ã-1024yr (90% C.L.) is set, corresponding to âmÎâ©â‰0.2 to 1.1 eV, depending on the theoretical nuclear matrix elements used in the analysis. © 2005 The American Physical Society.

Published
2005

62. CUORICINO status and CUORE prospects

Author

Brofferio, C, Ardito, R, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cosmelli, C, Cremonesi, O, Creswick, R, de Waard, A, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Mcdonald, R, Morganti, S, Nisi, S, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, McDonald, RJ, Morganti,S, Norman, EB, Smith, AR, Xu, N., Brofferio, C, Ardito, R, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cosmelli, C, Cremonesi, O, Creswick, R, de Waard, A, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Giuliani, A, Gorla, P, Guardincerri, E, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Mcdonald, R, Morganti, S, Nisi, S, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Dolinski, MJ, Farach, HA, Gutierrez, TD, Haller, EE, McDonald, RJ, Morganti,S, Norman, EB, Smith, AR, and Xu, N.

Published
2005

63. CUORICINO last results and CUORE R&D

Author

Tran Thanh Van J, Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinsky, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Marujama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quinter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, ZANOTTI, LUIGI ERNESTO, Tran Thanh Van J, Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Bellini, F, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Clemenza, M, Cosmelli, C, Cremonesi, O, Creswick, R, Dafinei, I, De Waard, A, Diemoz, M, Dolinsky, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Marujama, R, Morganti, S, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quinter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, Zanotti, L, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CLEMENZA, MASSIMILIANO, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, and ZANOTTI, LUIGI ERNESTO

Abstract

CUORICINO is a bolometric experiment on Neutrinoless Double Beta Decay (DBDOv) of 130Te. It consists of an array of 62 Te02 crystals with a total mass of - 40.7 kg. While being a self consistent experiment CUORICINO is also a good test for the feasibility of the next generation experiment CUORE, -750 kg of Te02 bolometric mass. In this paper last results from CUORICINO and prospects for the future CUORE experiment will be reported.

Published
2005

65. CUORE: a cryogenic underground observatory for rare events

Author

Arnaboldi, C, Avignone, F, Beemanc, J, Barucci, M, Balata, M, Brofferio, C, Buccie, C, Cebrian, S, Creswick, R, Capelli, S, Carbone, L, Cremonesi, O, de Ward, A, Fiorini, E, Farach, H, Frossati, G, Giuliani, A, Giugni, D, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Norman, E, Negri, P, Nucciotti, A, Pedretti, M, Pobes, C, Palmieri, V, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Rosenfeld, C, Smith, A, Sisti, M, Ventura, G, Vanzini, M, Zanotti, L, For the CUORE, C, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Avignone, FT, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, IJ, McDonald, RJ, Norman, EB, Smith, AR, For the CUORE Collaboration, Arnaboldi, C, Avignone, F, Beemanc, J, Barucci, M, Balata, M, Brofferio, C, Buccie, C, Cebrian, S, Creswick, R, Capelli, S, Carbone, L, Cremonesi, O, de Ward, A, Fiorini, E, Farach, H, Frossati, G, Giuliani, A, Giugni, D, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Norman, E, Negri, P, Nucciotti, A, Pedretti, M, Pobes, C, Palmieri, V, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Rosenfeld, C, Smith, A, Sisti, M, Ventura, G, Vanzini, M, Zanotti, L, For the CUORE, C, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Avignone, FT, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, IJ, McDonald, RJ, Norman, EB, Smith, AR, and For the CUORE Collaboration

Abstract

CUORE is a proposed tightly packed array of 1000 TeO2 bolometers, each being a cube 5 cm on a side with a mass of 760 g. The array consists of 25 vertical towers, arranged in a square of 5 towers×5 towers, each containing 10 layers of four crystals. The design of the detector is optimized for ultralow-background searches: for neutrinoless double-beta decay of 130Te (33.8% abundance), cold dark matter, solar axions, and rare nuclear decays. A preliminary experiment involving 20 crystals 3×3×6 cm3 of 340 g has been completed, and a single CUORE tower is being constructed as a smaller-scale experiment called CUORICINO. The expected performance and sensitivity, based on Monte Carlo simulations and extrapolations of present results, are reported. © 2003 Elsevier B.V. All rights reserved.

Published
2004

66. Last results from CUORICINO and perspectives for CUORE

Author

Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, De Waard, A, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Mcdonald, R, Morales, A, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, McDonald, RJ, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, Xu, N., Capelli, S, Ardito, R, Arnaboldi, C, Artusa, D, Avignone, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, De Waard, A, Dolinski, M, Farach, H, Ferroni, F, Fiorini, E, Frossati, G, Gargiulo, C, Guardincerri, E, Giuliani, A, Gorla, P, Gutierrez, T, Haller, E, Irastorza, I, Longo, E, Maier, G, Maruyama, R, Morganti, S, Mcdonald, R, Morales, A, Nisi, S, Nones, C, Norman, E, Nucciotti, A, Olivieri, E, Ottonello, P, Pallavicini, M, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Quiter, B, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Toffanin, S, Torres, L, Ventura, G, Xu, N, CAPELLI, SILVIA, ARNABOLDI, CLAUDIO, Artusa, DR, Avignone, FT, Beeman, JW, BROFFERIO, CHIARA, CAPOZZI, FRANCESCA, Creswick, RJ, Farach, HA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, Gutierrez, TD, Haller, EE, Irastorza, IG, McDonald, RJ, NONES, CLAUDIA, Norman, EB, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Smith, AR, and Xu, N.

Published
2004

67. CUORICINO: A new large bolometer array for astroparticle physics

Author

Previtali, E, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivieri, E, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Pobes, C, Pyle, M, Risegari, L, Rosenfeld, C, Sisti, M, Smith, A, Torres, L, Ventura, G, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Ventura, G., ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, FIORINI, ETTORE, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Previtali, E, Arnaboldi, C, Artusa, D, Avignone III, F, Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivieri, E, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Pobes, C, Pyle, M, Risegari, L, Rosenfeld, C, Sisti, M, Smith, A, Torres, L, Ventura, G, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Ventura, G., ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, FIORINI, ETTORE, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, and SISTI, MONICA

Abstract

After 3 years of project study and development, a 40 kg, 62-crystal, thermal detector array CUORICINO started last February. It is supposed to test the two claimed, but still not confirmed, evidences in Dark Matter and in Double Beta Decay (DBD) reported in the last few years and it will have a first glance on Solar Axion. The technical goals that were forseen for this experiment would be the confirmation on the feasibility of the CUORE experiment, a 1 ton multipurpose experiment with bolometers, that could open a new era in DBD physics. © 2003 Elsevier B.V. All rights reserved.

Published
2004

68. First results on neutrinoless double beta decay of 130Te with the calorimetric CUORICINO experiment

Author

Arnaboldi, C, Artusa, D, Avignone III, F, M. Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fascilla, A, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Haller, E, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivie, E, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Pobes, C, Previtali, E, Pyle, M, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EF, McDonald, RJ, Norman, EB, Smith, AR, Ventura, G., Arnaboldi, C, Artusa, D, Avignone III, F, M. Balata, M, Bandac, I, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Capozzi, F, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, de Waard, A, Farach, H, Fascilla, A, Fiorini, E, Frossati, G, Giuliani, A, Gorla, P, Haller, E, Mcdonald, R, Morales, A, Norman, E, Nucciotti, A, Olivie, E, Palmieri, E, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Pobes, C, Previtali, E, Pyle, M, Risegari, L, Rosenfeld, C, Sangiorgio, S, Sisti, M, Smith, A, Torres, L, Ventura, G, ARNABOLDI, CLAUDIO, BROFFERIO, CHIARA, CAPELLI, SILVIA, CAPOZZI, FRANCESCA, FIORINI, ETTORE, GIULIANI, ANDREA, GORLA, PAOLO, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, Artusa, DR, Avignone III, FT, Beeman, JW, Creswick, RJ, Farach, HA, Haller, EF, McDonald, RJ, Norman, EB, Smith, AR, and Ventura, G.

Abstract

The first results are reported on the limit for neutrinoless double decay of 130Te obtained with the new bolometric experiment CUORICINO. The set-up consists of 44 cubic crystals of natural TeO2, 5 cm on the side and 18 crystals of 3×3×6 cm3. Four of these latter crystals are made with isotopically enriched materials: two in 128Te and two others in 130Te. With a sensitive mass of ∼ 40 kg, our array is by far the most massive running cryogenic detector to search for rare events. The array is operated at a temperature of ∼ 10 mK in a dilution refrigerator under a heavy shield in the Gran Sasso Underground Laboratory at a depth of about 3500 m.w.e. The counting rate in the region of neutrinoless double beta decay is ∼ 0.2 counts keV−1 kg−1 y−1, among the lowest in this type of experiment. No evidence for neutrinoless double beta decay is found with the present statistics obtained in about three months with a live time of 72%. The corresponding lower limit for the lifetime of this process is of 5.5×1023 years at 90% C.L. The corresponding limit for the effective neutrino mass ranges between 0.37 to 1.9 eV depending on the theoretically calculated nuclear matrix elements used. This constraint is the most restrictive one except those obtained with Ge diodes, and is comparable to them.

Published
2004

69. CUORE: low-temperature techniques for neutrino physics

Author

Giuliani, A, Arnaboldi, C, Avignone, F, Balata, M, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, Farach, H, Fiorini, E, Frossati, G, Giugni, D, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Negri, P, Norman, E, Nucciotti, A, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Sisti, M, Smith, A, Vanzini, M, Ventura, G, De Waard, A, Zanotti, L, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, IG, McDonald, RJ, Norman, EB, Smith, AR, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, ZANOTTI, LUIGI ERNESTO, Giuliani, A, Arnaboldi, C, Avignone, F, Balata, M, Barucci, M, Beeman, J, Brofferio, C, Bucci, C, Capelli, S, Carbone, L, Cebrian, S, Cremonesi, O, Creswick, R, Farach, H, Fiorini, E, Frossati, G, Giugni, D, Gorla, P, Haller, E, Irastorza, I, Mcdonald, R, Morales, A, Negri, P, Norman, E, Nucciotti, A, Palmieri, V, Pasca, E, Pavan, M, Pedretti, M, Pessina, G, Pirro, S, Previtali, E, Sisti, M, Smith, A, Vanzini, M, Ventura, G, De Waard, A, Zanotti, L, Creswick, RJ, Farach, HA, Haller, EE, Irastorza, IG, McDonald, RJ, Norman, EB, Smith, AR, BROFFERIO, CHIARA, CAPELLI, SILVIA, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, SISTI, MONICA, and ZANOTTI, LUIGI ERNESTO

Abstract

Neutrino physics represents today a hot topic in elementary particle physics, due to the observations of flavour oscillations both in the atmospheric and in the solar sector. This proves the existence of finite neutrino masses. In order to fix their absolute values, sensitive experiments on Neutrinoless Double Beta Decay (a rare nuclear process) must be carried on. The experiment here described, named Cryogenic's Underground Observatory for Rare Events (CUORE), can extend the neutrino mass sensitivity down to 30 meV. CUORE will consist of a large, closely packed, high-granularity array of 1000 tellurite (TeO2) IOW-temperature calorimeters, operated at 10 mK and with a total mass of 800 kg. The final structure of the detector and the preliminary tests are presented and discussed

Published
2003

70. CUORE: The Cryogenic Underground Observatory for Rare Events

Author

Beeman, J, Haller, E, Mcdonald, R, Norman, E, Smith, A, Giuliani, A, Pedretti, M, Ventura, G, Balata, M, Bucci, C, Pobes, C, Palmieri, V, Frossati, G, de Waard, A, Brofferio, C, Capelli, S, Carbone, L, Cremonesi, O, Fiorini, E, Giugni, D, Negri, P, Nucciotti, A, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Vanzini, M, Zanotti, L, Avignone III, F, Creswick, R, Farach, H, Rosenfeld, C, Cembrian, S, Irastorza, I, Morales, A, Beeman, JW, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Avignone III, FT, Creswick, RJ, Farach, HA, Irastorza, IG, Morales, A., BROFFERIO, CHIARA, CAPELLI, SILVIA, CREMONESI, OLIVIERO, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, PESSINA, GIANLUIGI EZIO, PREVITALI, EZIO, ZANOTTI, LUIGI ERNESTO, Beeman, J, Haller, E, Mcdonald, R, Norman, E, Smith, A, Giuliani, A, Pedretti, M, Ventura, G, Balata, M, Bucci, C, Pobes, C, Palmieri, V, Frossati, G, de Waard, A, Brofferio, C, Capelli, S, Carbone, L, Cremonesi, O, Fiorini, E, Giugni, D, Negri, P, Nucciotti, A, Pavan, M, Pessina, G, Pirro, S, Previtali, E, Vanzini, M, Zanotti, L, Avignone III, F, Creswick, R, Farach, H, Rosenfeld, C, Cembrian, S, Irastorza, I, Morales, A, Beeman, JW, Haller, EE, McDonald, RJ, Norman, EB, Smith, AR, Avignone III, FT, Creswick, RJ, Farach, HA, Irastorza, IG, Morales, A., BROFFERIO, CHIARA, CAPELLI, SILVIA, CREMONESI, OLIVIERO, FIORINI, ETTORE, NUCCIOTTI, ANGELO ENRICO LODOVICO, PAVAN, MAURA, PESSINA, GIANLUIGI EZIO, PREVITALI, EZIO, and ZANOTTI, LUIGI ERNESTO

Abstract

The Cryogenic Underground Observatory for Rare Events (CUORE) will be a large-scale, multi-purpose observatory that is planned for construction in the Gran Sasso underground laboratory in Italy. Its primary focus will be on a search for the neutrinoless double-beta decay of 130Te. The source/detector will be composed of one thousand 5-cm×5-cm×5-cm single crystals of TeO2 all housed in a common dilution refrigerator. Attached to each crystal will be one or more neutron-transmutation-doped (NTD) germanium thermistors that will measure the small temperature rise produced in a crystal when radiation is absorbed. The high natural isotopic abundance of 130Te (33.8%) makes the use of isotopically enriched material unnecessary. In addition, the high Q-value for the double-beta decay of 130Te means that the peak in the summed electron energy spectrum expected from the neutrinoless mode will occur in an energy region of very little natural background. Once constructed, CUORE can also be used in searches for dark matter, solar axions, and other rare decay processes in nuclear physics.

Published
2002

77. A randomized, controlled investigation of motor cortex transcranial magnetic stimulation (TMS) effects on quantitative sensory measures in healthy adults: evaluation of TMS device parameters.

Author

Borckardt JJ, Reeves ST, Beam W, Jensen MP, Gracely RH, Katz S, Smith AR, Madan A, Patterson D, George MS, Borckardt, Jeffrey J, Reeves, Scott T, Beam, Will, Jensen, Mark P, Gracely, Richard H, Katz, Sophie, Smith, Arthur R, Madan, Alok, Patterson, David, and George, Mark S

Published
2011
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81. Revisiting impulsivity in suicide: implications for civil liability of third parties.

Author

Smith AR, Witte TK, Teale NE, King SL, Bender TW, Joiner TE, Smith, April R, Witte, Tracy K, Teale, Nadia E, King, Sarah L, Bender, Ted W, and Joiner, Thomas E

Abstract

Previous research and popular conceptualizations of suicide have posited that many suicides are the result of impulsive, "on a whim" decisions. However, recent research demonstrates that most suicides are not attempted impulsively, and in fact involve a plan. Legally, suicide has historically been considered to be a superseding intervening cause of death that exonerates other parties from liability, but currently there are two general exceptions to this view. Specifically, another party may be found responsible for a suicide if that party either caused the suicide or failed in its duty to prevent the suicide from occurring. Both of these exceptions assume that the resulting suicide was foreseeable. Given that recent research has indicated that most suicides are planned, and thereby foreseeable to a certain extent under many circumstances, this article discusses issues of foreseeability as they pertain to litigation involving third party liability for the suicide of university students, prison inmates, and mental health patients. The authors contend that the surest way for universities, prison staff, and mental health practitioners to avoid being held liable for a suicide is to appropriately assess for suicidal intent. [ABSTRACT FROM AUTHOR]

Published
2008
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82. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects [corrected] [published errata appear in ALTERN MED REV 2007;12(4):343-351].

Author

Carlson DA, Smith AR, Fischer SJ, Young KL, and Packer L

Abstract

BACKGROUND: The racemic mixture, RS-(+/-)-alpha-lipoic acid (rac-LA) has been utilized clinically and in a variety of disease models. Rac-LA and the natural form, R-lipoic acid (RLA), are widely available as nutritional supplements, marketed as antioxidants. Rac-LA sodium salt (NaLA) or rac-LA potassium salt (KLA) has been used to improve the aqueous solubility of LA. STUDY RATIONALE: Several in vitro and animal models of aging and age-related diseases have demonstrated efficacy for the oral solutions of LA salts in normalizing age-related changes to those of young animals. Other models and studies have demonstrated the superiority of RLA, the naturally occurring isomer over rac-LA. Despite this, RLA pharmacokinetics (PK) is not fully characterized in humans, and it is unknown whether the concentrations utilized in animal models can be achieved in vivo. Due to its tendency to polymerize, RLA is relatively unstable and suffers poor aqueous solubility, leading to poor absorption and low bioavailability. A preliminary study demonstrated the stability and bioavailability were improved by converting RLA to its sodium salt (NaRLA) and pre-dissolving it in water. The current study extends earlier findings from this laboratory and presents PK data for the 600-mg oral dosing of 12 healthy adult subjects given NaRLA. In addition, the effect of three consecutive doses was tested on a single subject relative to a one-time dosing in the same subject to determine whether plasma maximum concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) values were comparable to those in animal studies and those achievable via intravenous infusions in humans. METHODS: Plasma RLA was separated from protein by a modification of a published method. Standard curves were generated from spiking known concentrations of RLA dissolved in ethanol and diluted in a phosphate-buffered saline (PBS) into each individual's baseline plasma to account for inter-individual differences in protein binding and to prevent denaturing of plasma proteins. Plasma RLA content was determined by the percent recovery using high-performance liquid chromatography (electrochemical/coulometric detection) (HPLC/ECD). RESULTS: As anticipated from the preliminary study, NaRLA is less prone to polymerization, completely soluble in water, and displays significantly higher Cmax and AUC values and decreased time to maximum concentration (Tmax) and T1/2 values than RLA or rac-LA. In order to significantly extend Cmax and AUC, it is possible to administer three 600-mg RLA doses (as NaRLA) at 15-minute intervals to achieve plasma concentrations similar to those from a slow (20-minute) infusion of LA. This is the first study to report negligible unbound RLA even at the highest achievable plasma concentrations. [ABSTRACT FROM AUTHOR]

Published
2007

83. Neural complications in the surgical treatment of adolescent idiopathic scoliosis.

Author

Diab M, Smith AR, Kuklo TR, and Spinal Deformity Study Group

Abstract

STUDY DESIGN: Multicenter, prospective, consecutive clinical series. OBJECTIVE: To report on neural complications in a prospective cohort study of 1301 children undergoing spinal fusion and instrumentation for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: The incidence of neural complications for spinal deformity surgery has been reported to be 0.26% to 17%. However, most studies have relied on retrospective voluntary reporting of nonconsecutive cases. METHODS: A review of 1301 consecutive surgical cases was conducted using the Prospective Pediatric Scoliosis Study database, which is maintained by the Spinal Deformity Study Group. RESULTS: There were 9 neural complications. There were 3 thecal penetrations, none of which required repair, and none of which demonstrated intraoperative neural monitoring changes or postoperative clinical sequelae. There were 2 nerve root injuries. In 1 nerve root injury, a positional compression femoral neurapraxia resolved over 6 months. The other was an L4 neurapraxia despite lowest instrumented vertebra L1, and resolved spontaneously by 3 months' follow-up. There were 4 spinal cord injuries. One required removal of implants and fusion in situ, 1 required relaxation of correction and in situ fusion with instrumentation, while the other 2 were observed after fusion and instrumentation with reduction. All resolved spontaneously within 3 months after operation. CONCLUSION: The neural complication rate was 0.69%. Two thecal penetrations were due to medial placement of pedicle screws, and 1 was due to dissection during spine exposure. If these are eliminated, as they imply intraspinal entry but not direct neural injury, together with 1 positional neurapraxia, which is remote from the surgical field, our complication rate is 0.38%. This is consistent with other studies in the North American Literature, including multiple reports from the Scoliosis Research Society. Common themes are significant curve correction producing neural stretch and the use of sublaminar wires. None of the neural injuries was permanent. These results reaffirm that surgical treatment of adolescent idiopathic scoliosis has a low but real neural complication rate. [ABSTRACT FROM AUTHOR]

Published
2007
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84. The 2007 ABJS Marshall Urist Award: The impact of direct-to-consumer advertising in orthopaedics.

Author

Bozic KJ, Smith AR, Hariri S, Adeoye S, Gourville J, Maloney WJ, Parsley B, Rubash HE, Bozic, Kevin J, Smith, Amanda R, Hariri, Sanaz, Adeoye, Sanjo, Gourville, John, Maloney, William J, Parsley, Brian, and Rubash, Harry E

Abstract

Direct-to-consumer advertising (DTCA) has become an influential factor in healthcare delivery in the United States. We evaluated the influence of DTCA on surgeon and patient opinions and behavior in orthopaedics by surveying orthopaedic surgeons who perform hip and knee arthroplasties and patients who were scheduled to have hip or knee arthro-plasty. Respondents were asked for their opinions of and experiences with DTCA, including the influence of DTCA on surgeon and patient decision making. Greater than 98% of surgeon respondents had experience with patients who were exposed to DTCA. The majority of surgeon respondents reported DTCA had an overall negative impact on their practice and their interaction with patients (74%), and their patients often were confused or misinformed about the appropriate treatment for their condition based on an advertisement (77%). Fifty-two percent of patient respondents recalled seeing or hearing advertisements related to hip or knee arthroplasty. These patients were more likely to request a specific type of surgery or brand of implant from their surgeon and to see more than one surgeon before deciding to have surgery. Direct-to-consumer advertising seems to play a substantial role in surgeon and patient decision making in orthopaedics. Future efforts should be aimed at improving the quality and accuracy of information contained in consumer-directed advertisements related to orthopaedic implants and procedures. [ABSTRACT FROM AUTHOR]

Published
2007

85. Transdisciplinary assignments in graduate health education as a model for future collaboration.

Author

Christie C, Smith AR Jr., and Bednarzyk M

Abstract

Transdisciplinary health care continues to be at the forefront of patient treatment in the medical arena, in part due to escalating health care costs, an increasing aging population, and the development of multiple chronic diseases. Gaining the knowledge, experience, and principles associated with transdisciplinary teamwork to successfully prepare for modern-day practice is therefore essential for individuals of various health care professions. This report describes an assignment developed and implemented to facilitate professional interaction between graduate physical therapy, nutrition, and nursing students. The objectives of this assignment were to determine through student evaluation the effects of a transdisciplinary experience on students' understanding of the role of another discipline and students' communication skills across disciplines. When evaluating the assignment, students most often remarked that they developed a greater understanding of the roles of the included disciplines and reported a significant increase in communication skills. However, some students did not concur that this assignment was effective due to the scheduling conflicts and lack of teamwork that can occur during a collaborative project. The students' reports of their experiences in completing the assignment provide valuable insights for implementing and/or updating a preparatory transdisciplinary education component in other settings. Additional research can focus on the challenges faced by the majority of the students venturing into actual health care or 'real-world' settings for comparative studies. [ABSTRACT FROM AUTHOR]

Published
2007

88. Citalopram in the treatment of fibromyalgia.

Author

Kee WG, Smith AR, and Folk JW

Abstract

22 subjects were screened for either mild or moderate depression on the Beck Depression Inventory II (BDI) and primary idiopathic fibromyalgia out of a pool of 136. Subjects had one week of washout from medications. Subjects then were treated for 6 weeks with citalopram 20-40 mg. Measures taken at baseline, end of washout week and end of study included: BDI, Visual Analog Scale for pain, McGill Pain Questionnaire (MPQ), Sleep Questionnaire, Fibromyalgia Impact Questionnaire (FIQ), Pressure Threshold Gauge for Tender Points and Activity Diary.No consistent differences on independent variables were seen between subjects who completed the study and those who dropped out or between depressed and non-depressed patients. Regression analyses did not indicate any consistent relationship between subject variables and measures used in the study. Subject change during the 6 week medication trial showed significant improvement on: VAS scores, MPQ, FIQ, sleep, 4 tender points, 2 control points and pooled tender point score. Depressed subjects showed greater improvement than non-depressed. A maximum of 41.9% of the change in pain was attributable to depression leaving over 50% attributable to other factors. The study indicates that citalopram is effective in making changes in the symptoms of fibromyalgia beyond changes seen in mood. [ABSTRACT FROM AUTHOR]

Published
2004
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91. Microcirculatory Support by Fluorocarbons

Author

N. S. Faithfull, A. Kok, W. A. van Alphen, Smith Ar, Wilhelm Erdmann, and M. Fennema

Subjects
business.industry, Medicine, business
Abstract

Fluorocarbons, or more strictly perfluorochemical (PFC) containing plasma substitutes have a high solubility for the respiratory gases, a desirable feature for a plasma substitute. This was dramatically demonstrated by their ability to sustain life for many hours in rats almost completely devoid of red cells. The ability of PFCs to carry oxygen exceeds that of other hemodilutents and they have been shown to produce better oxygenation under conditions of hemodilution than hydroxyethyl starch, dextran solutions or stroma-free hemoglobin solutions.

Published
1987
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92. Limb Preservation in Replantation Surgery

Author

Smith Ar, Fennema M, van Alphen B, and Faithfull Ns

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Fingers, Hydroxyethyl Starch Derivatives, Adenosine Triphosphate, Amputation, Traumatic, Blood Substitutes, medicine.artery, Finger Injuries, Humans, Medicine, Foot Injuries, Electron microscopic, Fluorocarbons, Foot, business.industry, Conclusive evidence, Oxygenation, Middle Aged, Surgery, Oxygen, Perfusion, Drug Combinations, Amputated extremity, Fluosol, Thumb, Replantation, business
Abstract

Five patients are presented in whom a traumatically amputated extremity or digit was perfused with oxygenated Fluosol DA-20%. Perfusion lasted between 16 and 46 hours. Microcirculatory oxygenation was monitored using pO2 measurements. Moreover, K¿lactate, glucose, and ATP levels were measured and electron microscopic sections of the vessels were investigated at the end of the experiment. All above-mentioned parameters suggest that the tissue was sufficiently provided with oxygen and viable after many hours of perfusion. Conclusive evidence of the viability of a perfused digit was given by its successful replantation after 17 hours of Fluosol perfusion (at approximately 15 degrees C).

Published
1985
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94. Scoliosis surgery and its effect on back shape

Author

Jefferson, RJ, Weisz, I, Turner-Smith, AR, Harris, JD, and Houghton, GR

Abstract

Thirty-four patients with adolescent idiopathic scoliosis were assessed by radiography and the integrated shape imaging system (ISIS) both before and after spinal surgery. Twenty-seven patients underwent Harrington instrumentation, after which lateral indices of curvature were significantly improved, but changes in the transverse plane were less pronounced. Sublaminar wiring was carried out in two patients whose thoracic lordosis was corrected by the surgery. Five patients whose severe deformity had persisted after previous spinal surgery underwent costoplasty, which resulted in a significant improvement in back shape measurements. We conclude that the cosmetic deformity of the back in scoliosis is only partially corrected by operations on the spine itself, whilst costoplasty addresses the problem directly, and improves the surface shape.

Published
1988
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95. The Ability of Perfluorochemicals to Provide Microcirculatory Oxygenation

Author

M. Fenema, N. S. Faithfull, A. Trouwborst, R. Lapin, C. E. Essed, Smith Ar, W. A. van Alphen, and Wilhelm Erdmann

Subjects
Volume (thermodynamics), Chemistry, Oxygenation, Plasma Substitutes, Microcirculation, Biomedical engineering
Abstract

Perfluorochemicals have recently become available in the form of oxygen-carrying plasma substitutes containing 20% or 35% (weight by volume) of perfluorocarbons respectively. These preparations are known as Fluosol-DA 20% and Fluosol-DA 35%. The composition of these products is shown in Table 1. They have a number of interesting properties in relation to their oxygen-carrying ability and their ability to penetrate the microcirculation. This paper will discuss some of these properties.

Published
1985
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96. AV anastomosis as a solution for absent venous drainage in replantation surgery

Author

Smith Ar, Sonneveld Gj, and van der Meulen Jc

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Finger injury, Veins, Fingers, Arteriovenous Shunt, Surgical, Amputation, Traumatic, Finger Injuries, Medicine, Humans, Vein, AV Anastomosis, business.industry, Home Accidents, Venous drainage, Arteries, Surgery, surgical procedures, operative, medicine.anatomical_structure, Debridement, Thumb, Accidents, Home, Replantation, cardiovascular system, Female, business, Venous graft, Artery
Abstract

Three cases of replantation in which no conventional venous outflow could be established are presented. A method for obtaining venous outflow is described by using the contralateral artery as a venous pole and anastomosing it to a vein in the proximal stump (with or without a venous graft).

Published
1983

97. Tissue Oxygenation by Fluorocarbons

Author

R. Lapin, C. E. Essed, Wilhelm Erdmann, M. Fennema, Smith Ar, W. A. van Alphen, N. S. Faithfull, and A. Trouwborst

Subjects
Hydroxyethyl Starch Derivatives, Chromatography, Tissue oxygenation, Chemistry, Tissue oxygen tension, hemic and lymphatic diseases, chemistry.chemical_element, Solubility, Perfusion, Oxygen, Blood substitute
Abstract

Fluorocarbons have a very high solubility for oxygen and this was very dramatically shown by Clark and Gollan (1966), when they were able to demonstrate survival of mice completely immersed in these liquids for extended periods of time. The animals were able to obtain sufficient oxygen by respiring the liquid and after removal showed no apparent ill effects from the experience.

Published
1984
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98. The pineal gland of the mole (Talpa europaea L.)

Author

Pevet P, Kappers Ja, Juillard Mt, and Smith Ar

Subjects
Male, Biogenic Amines, Histology, Nerve Tissue Proteins, Endoplasmic Reticulum, Pineal Gland, Pathology and Forensic Medicine, Pineal gland, Catecholamines, Ependyma, Formaldehyde, Mole, medicine, Animals, Catecholaminergic, biology, Chemistry, Eulipotyphla, Cell Biology, biology.organism_classification, Fluorescence, Molecular biology, Tryptamines, Moles, medicine.anatomical_structure, Microscopy, Fluorescence, Darkness, Talpa, Female, Seasons
Abstract

The pineal gland of the mole, a mammal which lives in permanent darkness, has been studied using fluorescence histochemistry. An extensive catecholaminergic innervation is demonstrated. A yellow formaldehyde-induced fluorescence, characteristic of indoleamines, was not observed. If formaldehyde vapour treatment was omitted in the procedure, numerous cells containing yellow-orange autofluorescent material could be shown. The nature and possible function of this material is discussed.

Published
1976
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100. The Mammalian Pineal Gland and its Control of Hypothalamic Activity

Author

Smith Ar, de Vries Ra, and Kappers Ja

Subjects
endocrine system, Endoplasmic reticulum, Connective tissue, Biology, Golgi apparatus, Pinealocyte, symbols.namesake, Pineal gland, medicine.anatomical_structure, nervous system, Parenchyma, symbols, medicine, Endocrine system, Neurosecretion, Neuroscience, hormones, hormone substitutes, and hormone antagonists
Abstract

Publisher Summary This chapter gives general introduction surveying the essentials of mammalian pineal structure, innervation, biochemistry, and function. On morphological grounds, the mammalian pineal can be considered an endocrine organ. From a functional standpoint, however, the chapter hesitates to consider the mammalian pineal to be an endocrine organ in the classical sense, because till now, there is not a single pineal compound fulfilling all of the criteria of a pineal hormone, for example, a pineal substance being produced in the gland and having a specific functional influence on a specific target organ. The mammalian pineal is composed of strings of cells, often showing a pseudofollicular arrangement between these strings, connective tissue strands are present containing arterioles and venules. The parenchymal cell cords consist of pineal-specific cell elements, the pinealocytes. Most of their perikarya show, for example, a nucleus which is often lobulated, many mitochondria, rough and smooth endoplasmic reticulum and a well-developed Golgi apparatus producing dense-core and lucent vesicles.

Published
1974
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