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53. Supplementary Figure Legends from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors

Author

Proia, David A., primary, Smith, Donald L., primary, Zhang, Junyi, primary, Jimenez, John-Paul, primary, Sang, Jim, primary, Ogawa, Luisa Shin, primary, Sequeira, Manuel, primary, Acquaviva, Jaime, primary, He, Suqin, primary, Zhang, Chaohua, primary, Khazak, Vladimir, primary, Astsaturov, Igor, primary, Inoue, Takayo, primary, Tatsuta, Noriaki, primary, Osman, Sami, primary, Bates, Richard C., primary, Chimmanamada, Dinesh, primary, and Ying, Weiwen, primary

Published
2023
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56. Supplementary Table 1 from FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism

Author

Acquaviva, Jaime, primary, He, Suqin, primary, Zhang, Chaohua, primary, Jimenez, John-Paul, primary, Nagai, Masazumi, primary, Sang, Jim, primary, Sequeira, Manuel, primary, Smith, Donald L., primary, Ogawa, Luisa Shin, primary, Inoue, Takayo, primary, Tatsuta, Noriaki, primary, Knowles, Margaret A., primary, Bates, Richard C., primary, and Proia, David A., primary

Published
2023
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57. Supplementary Figure 3 from Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer

Author

Sang, Jim, primary, Acquaviva, Jaime, primary, Friedland, Julie C., primary, Smith, Donald L., primary, Sequeira, Manuel, primary, Zhang, Chaohua, primary, Jiang, Qin, primary, Xue, Liquan, primary, Lovly, Christine M., primary, Jimenez, John-Paul, primary, Shaw, Alice T., primary, Doebele, Robert C., primary, He, Suqin, primary, Bates, Richard C., primary, Camidge, D. Ross, primary, Morris, Stephan W., primary, El-Hariry, Iman, primary, and Proia, David A., primary

Published
2023
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61. Supplementary Figure Legends from FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism

Author

Acquaviva, Jaime, primary, He, Suqin, primary, Zhang, Chaohua, primary, Jimenez, John-Paul, primary, Nagai, Masazumi, primary, Sang, Jim, primary, Sequeira, Manuel, primary, Smith, Donald L., primary, Ogawa, Luisa Shin, primary, Inoue, Takayo, primary, Tatsuta, Noriaki, primary, Knowles, Margaret A., primary, Bates, Richard C., primary, and Proia, David A., primary

Published
2023
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67. Supplementary Figure 1 from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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68. Supplementary Figure 4 from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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69. Supplementary Methods, Figure Legend from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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70. Supplementary Table 1 from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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71. Supplementary Figure 3 from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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72. Supplementary Figure 2 from Preclinical Activity Profile and Therapeutic Efficacy of the HSP90 Inhibitor Ganetespib in Triple-Negative Breast Cancer

Author

Proia, David A., primary, Zhang, Chaohua, primary, Sequeira, Manuel, primary, Jimenez, John-Paul, primary, He, Suqin, primary, Spector, Neil, primary, Shapiro, Geoffrey I., primary, Tolaney, Sara, primary, Nagai, Masazumi, primary, Acquaviva, Jaime, primary, Smith, Donald L., primary, Sang, Jim, primary, Bates, Richard C., primary, and El-Hariry, Iman, primary

Published
2023
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74. Templates of expected measurement uncertainties

Author

Neudecker, Denise, Lewis, Amanda M., Matthews, Eric F., Vanhoy, Jeffrey, Haight, Robert C., Smith, Donald L., Talou, Patrick, Croft, Stephen, Carlson, Allan D., Pierson, Bruce, Wallner, Anton, Al-Adili, Ali, Bernstein, Lee, Capote, Roberto, Devlin, Matthew, Drosg, Manfred, Duke, Dana L., Finch, Sean, Herman, Michal W., Kelly, Keegan J., Koning, Arjan, Lovell, Amy E., Marini, Paola, Montoya, Kristina, Nobre, Gustavo P. A., Paris, Mark, Pritychenko, Boris, Sjöstrand, Henrik, Snyder, Lucas, Sobes, Vladimir, Solders, Andreas, Taieb, Julien, Neudecker, Denise, Lewis, Amanda M., Matthews, Eric F., Vanhoy, Jeffrey, Haight, Robert C., Smith, Donald L., Talou, Patrick, Croft, Stephen, Carlson, Allan D., Pierson, Bruce, Wallner, Anton, Al-Adili, Ali, Bernstein, Lee, Capote, Roberto, Devlin, Matthew, Drosg, Manfred, Duke, Dana L., Finch, Sean, Herman, Michal W., Kelly, Keegan J., Koning, Arjan, Lovell, Amy E., Marini, Paola, Montoya, Kristina, Nobre, Gustavo P. A., Paris, Mark, Pritychenko, Boris, Sjöstrand, Henrik, Snyder, Lucas, Sobes, Vladimir, Solders, Andreas, and Taieb, Julien

Abstract

The covariance committee of CSEWG (Cross Section Evaluation Working Group) established templates of expected measurement uncertainties for neutron-induced total, (n,gamma), neutron-induced charged-particle, and (n,xn) reaction cross sections as well as prompt fission neutron spectra, average prompt and total fission neutron multiplicities, and fission yields. Templates provide a list of what uncertainty sources are expected for each measurement type and observable, and suggest typical ranges of these uncertainties and correlations based on a survey of experimental data, associated literature, and feedback from experimenters. Information needed to faithfully include the experimental data in the nuclear-data evaluation process is also provided. These templates could assist (a) experimenters and EXFOR compilers in delivering more complete uncertainties and measurement information relevant for evaluations of new experimental data, and (b) evaluators in achieving a more comprehensive uncertainty quantification for evaluation purposes. This effort might ultimately lead to more realistic evaluated covariances for nuclear-data applications. In this topical issue, we cover the templates coming out of this CSEWG effort-typically, one observable per paper. This paper here prefaces this topical issue by introducing the concept and mathematical framework of templates, discussing potential use cases, and giving an example of how they can be applied (estimating missing experimental uncertainties of 235U(n,f) average prompt fission neutron multiplicities), and their impact on nuclear-data evaluations.

Published
2023
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75. Templates of expected measurement uncertainties for total neutron cross-section observables

Author

Lewis, Amanda M., Carlson, Allan D., Smith, Donald L., Barry, Devin P., Block, Robert C., Croft, Stephen, Danon, Yaron, Drosg, Manfred, Herman, Michal W., Neudecker, Denise, Otuka, Naohiko, Sjöstrand, Henrik, Sobes, Vladimir, Lewis, Amanda M., Carlson, Allan D., Smith, Donald L., Barry, Devin P., Block, Robert C., Croft, Stephen, Danon, Yaron, Drosg, Manfred, Herman, Michal W., Neudecker, Denise, Otuka, Naohiko, Sjöstrand, Henrik, and Sobes, Vladimir

Abstract

This paper provides a template of expected uncertainties and correlations for measurements of total neutron cross-section observables by transmission. Measurements with time-of-flight and mono-energetic neutron sources are covered. The information required for evaluations in the resonance region and high energy region is detailed, along with the template of uncertainties and correlations that can be used in the absence of other information.

Published
2023
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78. Mitigation impact of SiO2nanoparticles and mycorrhiza on wheat growth and yield under late-season drought stress

Author

Direkvandy, Somayeh, Eisvand, Hamid Reza, Azizi, Khosro, Akbarpour, Omidali, and Smith, Donald L.

Abstract

Wheat grain yields are reduced due to late-season drought, posing a challenge for cultivated areas that experiencing water scarcity. This research explores the impact of Nano-SiO2and mycorrhiza on wheat, aiming to mitigate drought effects. A two-year experiment was carried out with three factors and three replications. The factors were the interruption of irrigation (control, stopping irrigation at the end of the booting stage and stopping irrigation at the end of the flowering stage), foliar application of Nano-SiO2(0, 40 and 80 mg L−1) and mycorrhiza application (0 and 200 kg ha−1). The results indicated that drought stress decreased leaf area index, variable fluorescence (Fv), Fv/maximum fluorescence (Fm), stomatal conductance, net photosynthesis, sub stomatal CO2concentration and grain yield. Drought stress increased the grain protein percentage, and stomatal density. Application of Nano-SiO2and mycorrhiza increased grain yield. Nano-SiO2balances stomatal conductance and makes plants more drought-resistant by increasing the amount of silicon in leaves, leading to improved yield. Conversely, mycorrhiza may have played an important role in absorbing phosphorus and other elements from the soil in addition to absorbing moisture, which ultimately resulted in a drought-resistant plant. The combined treatment of mychorriza + foliar application of Nano-SiO2(80 mg L−1) increased grain yield by 39.43% under severe drought conditions (stopping irrigation at the end of the booting stage). In summary, the soil application of mycorrhiza and foliar Nano-SiO2is recommended for wheat production in regions where water deficit is a common issue during late-season wheat growth stages. Exploring the utilization of Nano-SiO2over an extended period throughout the wheat growth, alongside mycorrhiza application, appears to offer promising prospects for future research. Such endeavors aim to mitigate the impacts of drought stress.

Published
2024
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79. Co-inoculation of Phosphate-Solubilizing Bacteria and Mycorrhizal Fungi: Effect on Seed Yield, Physiological Variables, and Fixed Oil and Essential Oil Productivity of Ajowan (Carum copticumL.) Under Water Deficit

Author

Rezaei-Chiyaneh, Esmaeil, Mahdavikia, Hassan, Subramanian, Sowmyalakshmi, Alipour, Hadi, Siddique, Kadambot H. M., and Smith, Donald L.

Abstract

Rhizosphere symbiotic microorganisms play a significant role in mitigating the effects of water deficit on plant production. This work explores the effects of co-inoculation of phosphate-solubilizing bacteria (PSB) and arbuscular mycorrhizal fungi (AMF) on seed yield, essential oils (EOs), and oil composition of Ajowan under water deficit conditions. We assessed the response of Ajowan plants to individual or combined inoculation with AMF (Rhizophagus intraradices) and PSB (Pseudomonas putida+ Pantoea agglomerans) under several irrigation regimes (irrigation at 100% FC, 75% FC, and 50% FC, corresponding to normal irrigation, moderate water stress, and severe water stress, respectively). Normal irrigation with AMF + PSB co-inoculation produced the highest seed yield (870 kg ha−1). Moderate water stress with AMF + PSB co-inoculation yielded the most essential oil yield (22.3 kg ha−1). For inoculated and uninoculated plants, severe water stress decreased chlorophyll a by 44.80% relative to normal irrigation. Proline, soluble sugars, and carotenoid contents, and peroxidase, superoxide dismutase, and catalase activities increased with increasing water deficit, more so with AMF + PSB co-inoculation than individual inoculations. Water deficit also increased the essential oil content in Ajowan seeds. Co-inoculation with AMF and PSB increased the percentage of major EO components—thymol (50.94%) and γ-terpinene (33.18%)—and the main fatty acids—petroselinic (64.28–70.11%), oleic (16.05–21.9%), and palmitic acids (6.50–9.10%)—under moderate water stress, relative to uninoculated plants. Co-inoculation with AMF and PSB significantly improved EO quantity and quality in Ajowan seeds under moderate water stress.

Published
2024
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90. Characterization of endophytic bacteriome diversity and associated beneficial bacteria inhabiting a macrophyte Eichhornia crassipes.

Author

Di Fan, Schwinghamer, Timothy, Shuaitong Liu, Ouyuan Xia, Chunmei Ge, Qun Chen, and Smith, Donald L.

Subjects
ENDOPHYTIC bacteria, COMMUNITIES, MACROPHYTES, WATER hyacinth, PLANT growth, BACTERIAL communities, BACTERIA
Abstract

Introduction: The endosphere of a plant is an interface containing a thriving community of endobacteria that can affect plant growth and potential for bioremediation. Eichhornia crassipes is an aquatic macrophyte, adapted to estuarine and freshwater ecosystems, which harbors a diverse bacterial community. Despite this, we currently lack a predictive understanding of how E. crassipes taxonomically structure the endobacterial community assemblies across distinct habitats (root, stem, and leaf). Methods: In the present study, we assessed the endophytic bacteriome from different compartments using 16S rRNA gene sequencing analysis and verified the in vitro plant beneficial potential of isolated bacterial endophytes of E. crassipes. Results and discussion: Plant compartments displayed a significant impact on the endobacterial community structures. Stem and leaf tissues were more selective, and the community exhibited a lower richness and diversity than root tissue. The taxonomic analysis of operational taxonomic units (OTUs) showed that the major phyla belonged to Proteobacteria and Actinobacteriota (> 80% in total). The most abundant genera in the sampled endosphere was Delftia in both stem and leaf samples. Members of the family Rhizobiaceae, such as in both stem and leaf samples. Members of the family Rhizobiaceae, such as Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium were mainly associated with leaf tissue, whereas the genera Nannocystis and Nitrospira from the families Nannocystaceae and Nitrospiraceae, respectively, were statistically significantly associated with root tissue. Piscinibacter and Steroidobacter were putative keystone taxa of stem tissue. Most of the endophytic bacteria isolated from E. crassipes showed in vitro plant beneficial effects known to stimulate plant growth and induce plant resistance to stresses. This study provides new insights into the distribution and interaction of endobacteria across different compartments of E. crassipes Future study of endobacterial communities, using both culture-dependent and -independent techniques, will explore the mechanisms underlying the wide-spread adaptability of E. crassipesto various ecosystems and contribute to the development of efficient bacterial consortia for bioremediation and plant growth promotion. [ABSTRACT FROM AUTHOR]

Published
2023
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