Search

Copyright of Lung is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Plasma clearance of [sup 51]Cr-EDTA is widely used to assess the glomerular filtration rate (GFR) in diabetic nephropathy. Originally, the ratio between the intravenously injected amount of tracer and the total area under the plasma concentration curve was used for the calculation of total [sup 51]Cr-EDTA plasma clearance (C[sub T]). Simplified methods, using the final mono-exponential part of the plasma curve, have been suggested, e.g. four samples, taken 180 to 240 min after injection (C[sub IV]), or using one sample taken at 240 min (C[sub I]). Our aim was to evaluate the agreement between measurements of GFR and rate of in GFR based upon these three methods. Bland & Altman plots were used to illustrate the range of agreement. We investigated 76 insulin-dependent diabetic (IDDM) patients with microalbuminuria or diabetic nephropathy. GFR was measured after a single intravenous injection of 3.7 MBq [sup 51]Cr-EDTA by determining the radioactivity in venous blood samples taken 5, 7, 10, 15, 30, 45, 60, 90, 120, 150, 180, 200, 220,and 240 min after the injection. Rate of decline in GFR was assessed using 12 (6–17) determinations of GFR over a period of time of 8 (4–10) years. Mean (SD) GFR[sub T] was 123 (21) ml·min[sup -1] compared to GFR[sub IV] 123 (21) ml·min[sup -1] (NS) and GFR[sub I] 115 (17) ml·min[sup -1] (p<0.00001). The mean difference (95% limits of agreement) between GFR[sub T] and GFR[sub IV] was + 0.6 (–16.6 to + 17.7) ml·min[sup -1], and between GFR[sub T] and GFR[sub I] + 8.0 (–6.0 to + 22.2) ml·min[sup -1]. The difference between GFR[sub T] and GFR[sub I] was significantly correlated with their mean value (r=0.56, p<0.00001), indicating increasing underestimation by GFR[sub I] with increasing GFR levels. The mean (SD) rate of decline in GFR[sub T] was 2.3 (3.9) ml·min[sup -1]·year[sup -1], compared to a mean rate of decline in GFR[sub IV] of 2.4 (3.6) ml·min[sup -1]·year[sup -1] (NS), and a mean rate of decline in GFR[sub I] of 2.2 (3.5) ml·min[sup -1]·year[sup -1] (NS). The mean difference (95% limits of agreement) between rate of decline in GFR[sub T] and rate of decline in GFR[sub IV] was + 0.16 (–1.59 to + 1.91) ml·min[sup -1]·year[sup -1], and between rate of decline in GFR[sub T] and rate of decline in GFR[sub I] –0.01 (–1.64 to + 1.61) ml·min[sup -1]·year[sup -1], respectively. In conclusion, our cross-sectional study revealed a close agreement between GFR[sub T] and GFR[sub IV] with acceptable limits of agreement (precision), while GFR[sub I] lacked accuracy. However, a close agreement between rate of decline in GFR[sub T] and rate of decline in GFR[sub IV], and between rate of decline in GFR[sub T] and rate of decline in GFR[sub I], with acceptable limits of agreement (precision), suggests that both simplified methods are applicable for long-term follow-up. [ABSTRACT FROM AUTHOR]

The closing volume maneuvre allows the instillation of a gas bolus into the upper parts of the lung. During expiration heart synchronous partial pressure oscillations are likely to occur in phases II, III, and IV. The very distanct and constant oscillations observed during the CV maneuvre are appropriate for a detailed form analysis. In addition, this single-breath method allows an estimation of the influence of ventilatory distribution on the amplitude of the oscillations. For the formation of heart synchronous oscillations in the alveolar plateau of inert gases, two conditions have to be assumed: an inhomogeneous distribution of inspired gases during mixing from different lung compartments and a pulsatile change of gas flow. From this investigation it is evident that flow changes are directly caused by the pulsation of the large vessels in the thorax. Immersion has proved to be useful in demonstrating a close correlation between the oscillation and the radialis pulse. [ABSTRACT FROM AUTHOR]

Copyright of Internationales Archiv für Arbeitsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Internationales Archiv für Arbeitsmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pflügers Archiv: European Journal of Physiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pneumonologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)