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96 results on '"Slight, T."'

51. Synchronisation and chaos in a laser diode driven by a resonant tunnelling diode

Author

Romeira, B., Figueiredo, J., Slight, T., Wang, L., Wasige, E., Ironside, Charlie, Quintana, J., Avedillo, M., Romeira, B., Figueiredo, J., Slight, T., Wang, L., Wasige, E., Ironside, Charlie, Quintana, J., and Avedillo, M.

Abstract

The authors report on a hybrid integration of a resonant tunnelling diode laser diode driver configuration that can operate as a self-oscillating circuit, and when externally perturbed shows regions of frequency division and frequency multiplication, quasi-periodic and chaotic oscillations, both in the optical and electrical outputs. The authors also demonstrate that this optoelectronic circuit is well described as a Liénard's oscillator. The synchronisation capabilities of the circuit have potentially novel functions for optical communications systems including clock recovery, clock division and data encryption. © 2008 The Institution of Engineering and Technology.

Published
2008

53. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria

Author

van Vugt, M, Brockman, A, Gemperli, B, Luxemburger, C, Gathmann, I, Royce, C, Slight, T, Looareesuwan, S, White, N, Nosten, F, and Other departments

Subjects
parasitic diseases
Abstract

An open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both treatments rapidly and reliably cleared fever and parasitemia, and there was no significant difference in the initial therapeutic response parameters. Parasite genotyping was used to distinguish recrudescences from new infections. The 63-day cure rate for artesunate-mefloquine (94%) was significantly higher than the cure rate for artemether-benflumetol (81%) (P < 0.001). Both regimens were well tolerated. Nausea, vomiting, dizziness, sleep disorders, and other neurological side effects were between two and four times more common in the artesunate-mefloquine group than in the artemether-benflumetol group (P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than that used in the present study may improve efficacy.

Published
1998

59. Recent progress in short wavelength quantum cascade lasers

Author

Revin, D. G., primary, Commin, J. P., additional, Cockburn, J. W., additional, Zhang, S. Y., additional, Kennedy, K., additional, Krysa, A. B., additional, Hopkinson, M., additional, Slight, T., additional, McKee, A., additional, Meredith, W, additional, and Ironside, C., additional

Published
2011
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67. Short Wavelength Distributed Feedback Quantum Cascade Laser

Author

Slight, T. J., primary, Tandoi, G., additional, Ironside, C. N., additional, McKee, A., additional, Langton, C., additional, Eddie, I., additional, Revin, D. G., additional, Steer, M. J., additional, Zhang, S. Y., additional, Cockburn, J. W., additional, Passaro, V. M. N., additional, and De Leonardis, F., additional

Published
2009
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72. A Randomized, Controlled Study of a Simple, Once-Daily Regimen of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated, Multidrug-Resistant Falciparum Malaria

Author

Ashley, E. A., primary, McGready, R., additional, Hutagalung, R., additional, Phaiphun, L., additional, Slight, T., additional, Proux, S., additional, Thwai, K. L., additional, Barends, M., additional, Looareesuwan, S., additional, White, N. J., additional, and Nosten, F., additional

Published
2005
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94. Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.

Author

van Vugt M, Leonardi E, Phaipun L, Slight T, Thway KL, McGready R, Brockman A, Villegas L, Looareesuwan S, White NJ, and Nosten F

Subjects
Adolescent, Adult, Aged, Animals, Antimalarials adverse effects, Artemisinins adverse effects, Artemisinins therapeutic use, Artesunate, Atovaquone, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Naphthoquinones adverse effects, Naphthoquinones therapeutic use, Plasmodium falciparum drug effects, Proguanil adverse effects, Proguanil therapeutic use, Sesquiterpenes adverse effects, Sesquiterpenes therapeutic use, Treatment Failure, Antimalarials therapeutic use, Drug Resistance, Multiple physiology, Malaria, Falciparum drug therapy
Abstract

In an open-label trial carried out on the northwest border of Thailand, 1596 patients with uncomplicated multidrug-resistant falciparum malaria were randomly assigned to receive atovaquone-proguanil, atovaquone-proguanil-artesunate, or artesunate-mefloquine and were followed up for 42 days. All 3 regimens were highly effective and well tolerated. Fever duration and parasite clearance times were significantly shorter among patients who received artesunate (P<.001). Polymerase chain reaction genotyping confirmed that recrudescence occurred in 13 patients who received artesunate-mefloquine (2.4%), 5 who received atovaquone-proguanil-artesunate (0.9%), and 15 who received atovaquone-proguanil (2.8%). Adding artesunate to atovaquone-proguanil reduced the risk of failure 3-fold (95% confidence interval [CI], 1.1-8.2) and subsequent gametocyte carriage 21-fold (95% CI, 14-30). Gastrointestinal complaints in the first 48 h after initiation of treatment were more common among artesunate recipients, but after day 2, dizziness, sleep disturbance, nausea, vomiting, and anorexia were more common among mefloquine recipients (P< or =.014). Artesunate-atovaquone-proguanil is a highly effective and well-tolerated treatment for multidrug-resistant falciparum malaria.

Published
2002
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95. Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria.

Author

Newton PN, van Vugt M, Teja-Isavadharm P, Siriyanonda D, Rasameesoroj M, Teerapong P, Ruangveerayuth R, Slight T, Nosten F, Suputtamongkol Y, Looareesuwan S, and White NJ

Subjects
Acute Disease, Adolescent, Adult, Aged, Antimalarials blood, Area Under Curve, Artesunate, Biological Availability, Chromatography, High Pressure Liquid, Cross-Over Studies, Double-Blind Method, Female, Half-Life, Humans, Malaria, Falciparum blood, Male, Middle Aged, Sesquiterpenes blood, Spectrophotometry, Ultraviolet, Vietnam, Antimalarials pharmacokinetics, Artemisinins, Malaria, Falciparum metabolism, Sesquiterpenes pharmacokinetics
Abstract

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

Published
2002
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96. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria.

Author

van Vugt M, Brockman A, Gemperli B, Luxemburger C, Gathmann I, Royce C, Slight T, Looareesuwan S, White NJ, and Nosten F

Subjects
Adolescent, Adult, Aged, Antimalarials adverse effects, Artemether, Artesunate, Child, Double-Blind Method, Drug Resistance, Multiple, Ethanolamines adverse effects, Ethanolamines therapeutic use, Female, Fluorenes adverse effects, Fluorenes therapeutic use, Humans, Lumefantrine, Male, Mefloquine adverse effects, Mefloquine therapeutic use, Middle Aged, Prospective Studies, Sesquiterpenes adverse effects, Sesquiterpenes therapeutic use, Treatment Outcome, Antimalarials therapeutic use, Artemisinins, Malaria, Falciparum drug therapy
Abstract

An open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both treatments rapidly and reliably cleared fever and parasitemia, and there was no significant difference in the initial therapeutic response parameters. Parasite genotyping was used to distinguish recrudescences from new infections. The 63-day cure rate for artesunate-mefloquine (94%) was significantly higher than the cure rate for artemether-benflumetol (81%) (P < 0.001). Both regimens were well tolerated. Nausea, vomiting, dizziness, sleep disorders, and other neurological side effects were between two and four times more common in the artesunate-mefloquine group than in the artemether-benflumetol group (P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than that used in the present study may improve efficacy.

Published
1998
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