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53. Molecular basis of triclosan activity

Author

Levy, Colin W., Roujeinikova, Anna, Sedelnikova, Svetlana, Baker, Patrick J., Stuitje, Antoine R., Slabas, Antoni R., Rice, David W., and Rafferty, John B.

Published
1999

89. Extracellular ATP

Author

Chivasa, Stephen, primary, Tomé, Daniel F. A., additional, Murphy, Alex M., additional, Hamilton, John M., additional, Lindsey, Keith, additional, Carr, John P., additional, and Slabas, Antoni R., additional

Published
2009
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97. Fatty Acid Biosynthesis in Plants – Metabolic Pathways, Structure and Organization.

Author

Brown, Adrian P., Slabas, Antoni R., and Rafferty, John B.

Abstract

Progress in the elucidation of metabolic pathways for fatty acid and triacylglycerol biosynthesis in plants is reviewed, together with evidence for gene function. Research in this area is being driven by the importance of storage lipids as potential new raw materials to replace petrochemicals. Significant advances have been made in the structural analysis of a number of the soluble enzymes in these pathways but progress still has to be made on membrane-bound enzymes. Many of the enzymes of triacylglycerol biosynthesis have been identified but the relative importance of the acyl-CoA dependent and independent pathways remains to be determined. The role of particular isoenzymes in specific triacylglycerol assembly remains a major challenge together with determining higher orders of enzyme interaction and metabolic channeling. [ABSTRACT FROM AUTHOR]

Published
2010
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100. Discovery via Proteomics of a Novel Cell Signalling Pathway in Plants Involving Extracellular ATP.

Author

Šamaj, Jozef, Thelen, Jay J., Chivasa, Stephen, Simon, William J., Hamilton, John M., Lindsey, Keith, and Slabas, Antoni R.

Abstract

Proteomic techniques were used to identify plant extracellular matrix (ECM) proteins. Among the many classical cell wall proteins with known biochemical activity that were identified, new proteins predicted from their open reading frame in the database were localised to the ECM. Putative protein kinases and ATP-binding proteins were also identified in these cell wallenriched protein fractions. Bio-informatic analysis of the primary sequences of the putative kinases and ATP-binding proteins confirmed their ECM localisation, prompting a search for extracellular phosphoproteins. After identification of phosphorylated proteins in the plant ECM, subsequent experiments confirmed the existence of extracellular ATP and led to the discovery that extracellular ATP is a repressor of cell death in plants. Furthermore, external ATP has emerged as a control point of pathogen elicitor-induced programmed cell death. The studies described here constitute an example of how proteomics can be a powerful tool to drive discovery of novel signalling and/or metabolic pathways through integration of systematic protein identification, bio- informatics, and downstream hypothesis testing. [ABSTRACT FROM AUTHOR]

Published
2007
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