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The novel coronavirus (SARS-CoV-2) infection, more commonly referred to as COVID-19, has rapidly developed into a worldwide pandemic with a significant health burden. At the time of this research there are no approved pharmacological treatments or preventative therapeutic strategies in place to combat the infection. However, globally, hundreds of clinical studies that aim to discover effective COVID-19 treatments are ongoing. This article summarises the rationale behind several of these interventional trials, including evidence from in vitro studies, and early results to provide an insight into the global response. As patients are being enrolled in clinical trials across the UK, some of the safety and practical considerations for the investigational medicines that pharmacists are most likely to encounter in practice are discussed as part of this review. Keywords: coronavirus; SARS-CoV-2; COVID-19; 2019-nCoV; clinical trial; remdesivir; favipiravir; hydroxychloroquine; lopinavir; ritonavir; corticosteroids; interferons.

Millions of people in the world depend on traditional medicinal plants for treatment of many diseases.  They have curative properties due to presence of various complex chemical substances of different composition, which are found as secondary plant metabolites in one or more parts of these plants. These plant metabolites according to their composition are grouped as flavonoids, tannins, alkaloids, saponins etc. Guiera senegalensis(Gs), which grows in abundance in semi-desert area of Western Africa such as Nigeria, has been used for treating specific diseases and wounds. The study is carried out to investigate the phytochemical analysis, toxicity, and the antifungal activity of Gs leaves extract. Keywords: Guiera senegalensis, Antifungal activity, Brine shrimp, toxicity, phytochemical analysis