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51. Traitement antiagrégant plaquettaire après stenting carotidien en urgence lors des thrombectomies cérébrales pour occlusions en tandem–impact sur la perméabilité des stents au-delà des premières 24 heures

Author

Pop, Raoul, primary, Hasiu, Anca, additional, Mangin, Pierre, additional, Severac, Francois, additional, Mihoc, Dan, additional, Nistoran, Daiana, additional, Manisor, Monica, additional, Simu, Mihaela, additional, Chibbaro, Salvatore, additional, Gheoca, Roxana, additional, Quenardelle, Veronique, additional, Rouyer, Olivier, additional, Wolff, Valerie, additional, and Beaujeux, Remy, additional

Published
2021
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54. Levodopa-Carbidopa Intestinal Gel Infusion Therapy Discontinuation: A Ten-Year Retrospective Analysis of 204 Treated Patients

Author

Constantin,Viorelia Adelina, Szász,József Attila, Orbán-Kis,Károly, Rosca,Elena Cecilia, Popovici,Maria, Cornea,Amalia, Bancu,Ligia Ariana, Ciorba,Marius, Mihály,István, Nagy,Előd, Szatmári,Szabolcs, and Simu,Mihaela

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Viorelia Adelina Constantin, 1, 2, * József Attila Szász, 1, 3, * Károly Orbán-Kis, 1, 4 Elena Cecilia Rosca, 5, 6 Maria Popovici, 7 Amalia Cornea, 5, 6 Ligia Ariana Bancu, 8, 9 Marius Ciorba, 8, 10 István Mihály, 1, 4 Előd Nagy, 11, 12 Szabolcs Szatmári, 1, 3 Mihaela Simu 5, 6 1 2nd Clinic of Neurology, Târgu Mureș County Emergency Clinical Hospital, Târgu Mureș, Romania; 2Doctoral School, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 3Department of Neurology, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; 4Department of Physiology, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; 5Department of Neurology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 6Department of Neurology, “Pius Branzeu” Emergency Clinical County Hospital, Timisoara, Romania; 7Neurotim Med SRL, Timisoara, Romania; 8Department of Internal Medicine, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; 9 1st Clinic of Internal Medicine, Târgu Mureș County Emergency Clinical Hospital, Târgu Mureș, Romania; 10Department of Gastroenterology, Târgu Mureș County Emergency Clinical Hospital, Târgu Mureș, Romania; 11Department of Biochemistry and Environmental Chemistry, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureș, Romania; 12Laboratory of Medical Analysis, Clinical County Hospital Mureș, Târgu Mureș, Romania*These authors contributed equally to this workCorrespondence: Károly Orbán-KisDepartment of Physiology, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gh. Marinescu Street No. 38, Târgu Mureș 540142, RomaniaTel +40743754525Email karoly.orban-kis@umfst.roBackground: Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease. In the advanced stages, the continuous delivery of levodopa (LD) as levodopa-carbidopa intestinal gel (LCIG) has demonstrated significant improvement of motor and nonmotor complications and improvement of the patients’ quality of life (QoL). Despite the growing global experience with this treatment, anumber of unsolved practical issues remain, and currently, the data on the reasons that can lead to the discontinuation of LCIG are scarce.Objective: In the present study, we aimed to analyze the causes that led to the discontinuation of LCIG therapy.Methods: In this retrospective study, after 10 years of experience with LCIG as a therapeutic option in advanced PD, we analyzed the data of all dropout cases among the 204 patients that initiated LCIG therapy in two Romanian centers.Results: Of the 204 patients enrolled, 43 patients dropped out. Disease duration until LCIG infusion was significantly longer (11.67± 4.98 vs 9.44± 3.44) and the overall clinical picture more sever (both regarding motor symptoms and cognitive decline) in dropout patients (compared to patients who continued treatment). The dropout patients also presented significant differences regarding the incidence of polyneuropathy (32.5% vs 11.18%). The main cause of discontinuation was death.Conclusion: The causes of discontinuation from LCIG therapy in Romanian patients are similar to those from other centers; however, the rate of dropouts is somewhat lower. The clinician’s experience in selecting and treating the patients in advanced stages of PD can increase therapeutic adherence. Also, the presence of a well-trained caregiver along with the availability of a proper aftercare system is mandatory for maintaining the long-term benefits of the therapy and the overall best outcome possible. Targeted prospective studies are needed to confirm whether a more severe stage of the disease and cognitive impairment at the time of initiation, respectively, the association of polyneuropathy can be considered as predictive factors for dropout.Keywords: advanced Parkinson’s disease, levodopa-carbidopa intestinal gel, therapy discontinuation, polyneuropathy

Published
2020

56. Characterizing Advanced Parkinson’s Disease: Romanian Subanalysis from the OBSERVE-PD Study

Author

Szasz, Jozsef Attila, primary, Jianu, Dragos Catalin, additional, Simu, Mihaela Adriana, additional, Constantin, Viorelia Adelina, additional, Dulamea, Adriana Octaviana, additional, Onuk, Koray, additional, Popescu, Diana, additional, Vasile, Mihai-Titus, additional, Popescu, Bogdan Ovidiu, additional, Fasano, Alfonso, additional, and Bajenaru, Ovidiu Alexandru, additional

Published
2021
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57. Effectiveness of Psychostimulant and Non-Psychostimulant Drug Therapy in the Attention Deficit Hyperactivity Disorder

Author

Cojocaru, Adriana, primary, Hogea, Lavinia Maria, additional, Poroch, Vladimir, additional, Simu, Mihaela Adriana, additional, Enatescu, Virgil Radu, additional, Jeleriu, Roxana, additional, Andreescu, Nicoleta Ioana, additional, Puiu, Maria, additional, Hogea, Bogdan Gheorghe, additional, Grigoras, Mirela, additional, Folescu, Roxana, additional, Zamfir, Carmen Lăcrămioara, additional, Enatescu, Ileana, additional, and Nussbaum, Laura Alexandra, additional

Published
2021
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60. Application of the ‘5-2-1’ screening criteria in advanced Parkinson’s disease: interim analysis of DUOGLOBE

Author

Aldred, Jason, primary, Anca-Herschkovitsch, Marieta, additional, Antonini, Angelo, additional, Bajenaru, Ovidiu, additional, Bergmann, Lars, additional, Bourgeois, Paul, additional, Cubo, Esther, additional, Davis, Thomas L, additional, Iansek, Robert, additional, Kovács, Norbert, additional, Kukreja, Pavnit, additional, Onuk, Koray, additional, Pontieri, Francesco E, additional, Robieson, Weining, additional, Siddiqui, Mustafa S, additional, Simu, Mihaela, additional, Standaert, David G, additional, and Chaudhuri, K Ray, additional

Published
2020
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62. Study on the Role of Inflammatory Markers and Type D Personality on Symptom Profiles and Severity in Patients with Major Depressive Disorder

Author

Enatescu, Ileana, primary, Kalinovic, Raluka, additional, Giurgi-Oncu, Catalina, additional, Poroch, Vladimir, additional, Stratulat, Ioan Sorin, additional, Vlad, Gabriela, additional, Neda-Stepan, Oana, additional, Simu, Mihaela, additional, Papava, Ion, additional, Oancea, Roxana, additional, Patrascu, Raul, additional, and Enatescu, Virgil Radu, additional

Published
2020
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64. Local anesthesia versus general anesthesia during endovascular therapy for acute stroke: a propensity score analysis

Author

Pop, Raoul, primary, Severac, François, additional, Happi Ngankou, Emmanuel, additional, Harsan, Oana, additional, Martin, Ioan, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Simu, Mihaela, additional, Chibbaro, Salvatore, additional, Wolff, Valérie, additional, Gheoca, Roxana, additional, Meyer, Alain, additional, Pottecher, Julien, additional, Audibert, Gérard, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Bracard, Serge, additional, Anxionnat, René, additional, Richard, Sébastien, additional, Beaujeux, Rémy, additional, and Gory, Benjamin, additional

Published
2020
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65. Improvements in Dyskinesia with Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease Patients in a ‘Real-World’ Study: Interim Results of the Multinational DUOGLOBE Study With up to 24 Months Follow-Up (1824)

Author

Aldred, Jason, primary, Kovacs, Norbert, additional, Pontieri, Francesco, additional, Standaert, David, additional, Bourgeois, Paul, additional, Davis, Thomas, additional, Cubo, Esther, additional, Anca-Herschkovitsch, Marieta, additional, Iansek, Robert, additional, Siddiqui, Mustafa, additional, Simu, Mihaela, additional, Bergmann, Lars, additional, Kukreja, Pavnit, additional, Robieson, Weining, additional, and Chaudhuri, Ray, additional

Published
2020
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67. The role of personality dimensions and trait anxiety in increasing the likelihood of suicide ideation in women during the perinatal period

Author

Enătescu, Ileana, primary, Craina, Marius, additional, Gluhovschi, Adrian, additional, Giurgi-Oncu, Cătălina, additional, Hogea, Lavinia, additional, Nussbaum, Laura Alexandra, additional, Bernad, Elena, additional, Simu, Mihaela, additional, Cosman, Doina, additional, Iacob, Daniela, additional, Marinescu, Ileana, additional, and Enătescu, Virgil Radu, additional

Published
2020
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70. Extensive validation study of the Parkinson's Disease Composite Scale

Author

Martinez-Martin, P. Radicati, F. G. Rodriguez Blazquez, C. and Wetmore, J. Kovacs, N. Chaudhuri, K. Ray Stocchi, F. and Vuletic, Vladimira Falup-Pecurariu, Cristian Diaconu, Stefania and Johansson, Anders Sundgren, Mathias Simitsi, Athima and Stefanis, Leonidas Gurevich, Tanya Migirov-Sanderovich, Angel and Ezra, Adi Guekht, Alla Popov, Georgy Stamelou, Maria and Giagkou, Nikolaos Stefani, Alessandro Cerroni, Rocco Corbo, Massimo Grassi, Andrea Dellaporta, Dionysia Tsolaki, Magda and Ariadne, Vakirli Kefalopoulou, Zinovia Ellul, John Mir, Pablo Adarmes, Astrid D. Mendez-del-Barrio, Carlota and Skorvanek, Matej Necpal, Jan Bostantjopoulou, Sevasti Zoe, Katsarou Minar, Michal Simu, Mihaela Rosca, Cecilia and Popovici, Maria Kostic, Vladimir S. Marti, Maria J. and Planelles, Lluis Kovacs, Norbert Aschermann, Zsuzsanna and Juhasz, Annamaria Harmat, Mark PDCS European Study Grp

Subjects
hemic and immune systems
Abstract

Background and purpose A composite instrument able to rapidly and reliably assess the most relevant motor and non-motor afflictions suffered by Parkinson’s disease (PD) patients in a real world clinic setting is an unmet need. The recently validated PD Composite Scale (PDCS) was designed to fulfil this gap as a quick, comprehensive PD assessment. The objective of this study was extensive evaluation of the PDCS’s clinimetric properties using a large international sample. Methods This was a cross-sectional study in which the PDCS, the Movement Disorder Society Unified Parkinson’s Disease Rating Scale and the Clinical Impression of Severity Index for PD were applied. Basic clinimetric attributes of the PDCS were analysed. Results In total, 776 PD patients were included. The PDCS total score showed negligible floor and ceiling effects. Three factors (54.5% of the variance) were identified: factor 1 included motor impairment, fluctuations and disability; factor 2, non-motor symptoms; and factor 3, tremor and complications of therapy. Cronbach’s alpha was from 0.66 to 0.79. Inter-rater reliability showed weighted kappa values from 0.79 to 0.98 for items and intraclass correlation coefficient values from 0.95 (Disability) to 0.99 (Motor and total score). The Bland-Altmann method, however, showed irregular concordance. PDCS standard error of measurement and convergent validity with equivalent constructs of other measures were satisfactory (>= 0.70). PDCS scores significantly differed by Hoehn and Yahr stage. Conclusion Overall, in line with previous findings, the PDCS is a feasible, acceptable, valid, reliable and precise instrument for quickly and comprehensively assessing PD patients.

Published
2019

71. Affective theory of mind in Parkinson’s disease: the effect of cognitive performance

Author

Romosan,Ana-Maria, Dehelean,Liana, Romosan,Radu-Stefan, Andor,Minodora, Bredicean,Ana Cristina, Simu,Mihaela Adriana, Romosan,Ana-Maria, Dehelean,Liana, Romosan,Radu-Stefan, Andor,Minodora, Bredicean,Ana Cristina, and Simu,Mihaela Adriana

Abstract

Ana-Maria Romosan,1,* Liana Dehelean,1,* Radu-Stefan Romosan,1,* Minodora Andor,2 Ana Cristina Bredicean,1 Mihaela Adriana Simu31Department of Neurosciences, Discipline of Psychiatry, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 2Department of Internal Medicine, Discipline of Medical Semiology II, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania; 3Department of Neurosciences, Discipline of Neurology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaCorrespondence: Liana DeheleanDepartment of Neurosciences, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, Timisoara 300041, RomaniaTel +40 72 498 1888Fax +40 25 649 0626Email dehelean.liana@gmail.com*These authors contributed equally to this workPurpose: Among other non-motor symptoms, theory of mind (ToM), the ability to recognize, understand and infer others’ mental states, beliefs, intents and wishes, has been shown to deteriorate during the course of Parkinson’s disease (PD). It has been speculated that ToM impairments could be related to cognitive deficits in PD. However, the current state of literature suggests that there is heterogeneity regarding the involvement of cognitive functioning in the relationship of PD and ToM. The study aimed to measure affective ToM abilities and cognitive performance in a sample of PD patients, to explore the link between affective ToM abilities and cognitive status, and to examine the impact of PD on affective ToM through the mediator effect of cognitive performance.Patients and methods: Sixty-five patients diagnosed with idiopathic PD and 51 healthy controls matched for age, gender and educational level completed a visual affective ToM task (Reading the Mind in the Eyes – RMET), cognitive performance was evaluated with Montreal Cognitive Assessment, and psychiatric symptoms wer

Published
2019

73. The role of personality dimensions and trait anxiety in increasing the likelihood of suicide ideation in women during the perinatal period.

Author

Enătescu, Ileana, Craina, Marius, Gluhovschi, Adrian, Giurgi-Oncu, Cătălina, Hogea, Lavinia, Nussbaum, Laura Alexandra, Bernad, Elena, Simu, Mihaela, Cosman, Doina, Iacob, Daniela, Marinescu, Ileana, and Enătescu, Virgil Radu

Subjects
SUICIDAL ideation, PERINATAL period, PERSONALITY, ANXIETY, MENTAL depression, SUICIDE risk factors, PRENATAL depression, PREGNANT women, ANXIETY disorders, LONGITUDINAL method
Abstract

Introduction: Increasing amount of data reveal that suicide risk is a real phenomenon among perinatal women, determined by several other psychopathological conditions with depression being just one of them. This study aimed to investigate the role of personality dimensions on the occurrence of suicide ideation during the perinatal period.Methods: A longitudinal prospective study was performed in pregnant women who were monitored at university-based obstetrical care units in our county. Recruited women were reassessed between 6 and 8 weeks into their postnatal period. Trait and state anxiety, five-factor based dimensions of personality, and depressive symptoms were assessed using established psychometric measures. Appropriate statistical analyses were conducted, depending on the distribution of variables.Results: Significant levels of state anxiety (33.7% vs. 15.5%), depressive symptoms (19.8% vs. 8.5%), and suicide risk (13.9% vs. 6.3%) have halved in the postnatal period compared to the antenatal assessment. A lower level of education was associated with the presence of postnatal suicide ideation (p = .041), while an unemployed professional status was more frequent in pregnant women presenting antenatal suicide ideation (p = .021). Trait anxiety was predictive for the appearance of suicide ideation within the entire perinatal period assessed (p < .001 and p = .007, respectively). Agreeableness and conscientiousness predicted antenatal suicide ideation (p = .033 and p = .032, respectively).Discussions: Different dimensions of personality may play a contributing role in the development of suicide ideation in perinatal women. Consequently, personality dimensions and trait anxiety, not only depressive symptoms, should be investigated when attempting to identify perinatal women at risk of suicide. [ABSTRACT FROM AUTHOR]

Published
2021
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74. Embolization of very small (≤3 mm) unruptured intracranial aneurysms: A large single-center experience on treatment of unruptured versus ruptured cases

Author

Pop, Raoul, primary, Aloraini, Ziad, additional, Mihoc, Dan, additional, Burta, Horatiu, additional, Manisor, Monica, additional, Richter, Johann Sebastian, additional, Simu, Mihaela, additional, Chibbaro, Salvatore, additional, Proust, François, additional, Wolff, Valérie, additional, and Beaujeux, Rémy, additional

Published
2019
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76. Mathematical Model for Reducing the Concentration of a Chemical Substance Applicable in the Procedures of Plasmatic Treatment

Author

Gindac, Ciprian Mihai, primary, Bedreag, Ovidiu Horea, additional, Nussbaum, Laura Alexandra, additional, Micu Serbu, Iulia Bianca, additional, Folescu, Roxana, additional, Grigoras, Mirela, additional, Hogea, Lavinia Maria, additional, Simu, Mihaela Adriana, additional, Lupu, Viorel, additional, Boanca, Mihaela, additional, and Sandesc, Dorel, additional

Published
2019
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77. Levodopa-Carbidopa Intestinal Gel for the Treatment of Motor Fluctuations and Dyskinesia in Patients with Advanced Parkinson’s Disease in a ‘Real World’ Setting: Results of an Interim Analysis of the Multinational Observational Long-term Study DUOGLOBE (S4.004)

Author

Standaert, David G., primary, Aldred, Jason, additional, Anca-Herschkovitsch, Marieta, additional, Davis, Thomas L., additional, Iansek, Robert, additional, Kovács, Norbert, additional, Siddiqui, Mustafa S., additional, Pontieri, Francesco E., additional, Simu, Mihaela, additional, Bergmann, Lars, additional, Kukreja, Pavnit, additional, Li, Mei, additional, and Chaudhuri, K. Ray, additional

Published
2019
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78. Ursodeoxicholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy

Author

Timircan, Madalina Otilia, primary, Hogea, Lavinia Maria, additional, Cirlogea, Andreea, additional, Cojocaru, Ioana, additional, Zorzoana, Irina, additional, Nussbaum, Laura Alexandra, additional, Folescu, Roxana, additional, Hogea, Bogdan Gheorghe, additional, Simu, Mihaela, additional, Pascu, Alina Mihaela, additional, Boanca, Mihaela, additional, and Gomoi, Evelina, additional

Published
2019
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79. Montreal cognitive assessment for evaluating cognitive impairment in Huntington’s disease: a systematic review

Author

Rosca, Elena Cecilia and Simu, Mihaela

Abstract

AbstractObjectiveThis study aims to systematically review evidence of the accuracy of the Montreal Cognitive Assessment (MoCA) for evaluating the presence of cognitive impairment in patients with Huntington’s disease (HD) and to outline the quality and quantity of research evidence available about the use of the MoCA in this population.MethodsWe conducted a systematic literature review, searching four databases from inception until April 2020.ResultsWe identified 26 studies that met the inclusion criteria: two case–control studies comparing the MoCA to a battery of tests, three studies comparing MoCA to Mini-Mental State Examination, two studies estimating the prevalence of cognitive impairment in individuals with HD and 19 studies or clinical trials in which the MoCA was used as an instrument for the cognitive assessment of participants with HD. We found no cross-sectional studies in which participants received the index test (MoCA) and a reference standard diagnostic assessment composed of an extensive neuropsychological battery. The publication period ranged from 2010 to 2020.ConclusionsIn patients with HD, the MoCA provides information about disturbances in general cognitive function. Even if the MoCA demonstrated good sensitivity and specificity when used at the recommended threshold score of 26, further cross-sectional studies are required to examine the optimum cutoff score for detecting cognitive impairments in patients with HD. Moreover, more studies are necessary to determine whether the MoCA adequately assesses cognitive status in individuals with HD.

Published
2022
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80. Local anesthesia versus general anesthesia during endovascular therapy for acute stroke: a propensity score analysis.

Author

Pop, Raoul, Severac, François, Happi Ngankou, Emmanuel, Harsan, Oana, Martin, Ioan, Mihoc, Dan, Manisor, Monica, Simu, Mihaela, Chibbaro, Salvatore, Wolff, Valérie, Gheoca, Roxana, Meyer, Alain, Pottecher, Julien, Audibert, Gérard, Derelle, Anne-Laure, Tonnelet, Romain, Liang Liao, Zhu, François, Bracard, Serge, and Anxionnat, René

Subjects
ENDOVASCULAR surgery, CEREBRAL ischemia, CONFIDENCE intervals, LOCAL anesthesia, MEDICAL records, PROBABILITY theory, STROKE, SURGICAL complications, VEIN surgery, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, GENERAL anesthesia, ACQUISITION of data methodology, ODDS ratio, THROMBECTOMY, EVALUATION
Abstract

Background To date, the choice of optimal anesthetic management during endovascular therapy (EVT) of acute ischemic stroke patients remains subject to debate. We aimed to compare functional outcomes and complication rates of EVT according to the first-line anesthetic management in two comprehensive stroke centers: local anesthesia (LA) versus general anesthesia (GA). Methods Retrospective analysis of prospectively collected databases, identifying all consecutive EVT for strokes in the anterior circulation performed between January 1, 2018 and December 31, 2018 in two EVT-capable stroke centers. One center performed EVT under LA in the first intention, while the other center systematically used GA. Using propensity score analysis, the two groups underwent 1:1 matching, then procedural metrics, complications, and clinical outcomes were compared. Good outcome was defined as 90 days modified Rankin Scale (mRS) <2, and successful recanalization as modified Thrombolysis In Cerebral Ischemia (mTICI) 2b-3. Results During the study period, 219 patients were treated in the LA center and 142 in the GA center. Using the propensity score, 97 patients from each center were matched 1:1 according to the baseline characteristics. Local anesthesia was associated with a significantly lower proportion of good outcome (36.1% vs 52.0%, OR 0.53, 95% CI 0.33 to 0.87; p=0.039), lower rate of successful recanalization (70.1% vs 95.8%, OR 0.13, 95% CI 0.04 to 0.39; p<0.001), and more procedural complications (14.4% vs 3.0%, OR 3.44, 95% CI 1.09 to 14.28; p=0.018). There were no significant differences in 90-day mortality or symptomatic hemorrhagic transformation rates. Conclusions In this study, systematic use of GA for stroke EVT was associated with better clinical outcomes, higher recanalization rates, and fewer procedural complications compared with patients treated under LA as the primary anesthetic approach. [ABSTRACT FROM AUTHOR]

Published
2021
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81. THE EFFICACY OF CLONIDINE IN THE PHARMACOLOGICAL MANAGEMENT OF ALCOHOL WITHDRAWAL SYNDROME: PRELIMINARY RESULTS.

Author

ENĂTESCU, VIRGIL RADU, KALINOVIC, RALUKA, DEHELEAN, CRISTINA ADRIANA, GIURGI-ONCU, CĂTĂLINA, HOGEA, LAVINIA MARIA, IFTENI, PETRU, VLAD, GABRIELA, NEDA-STEPAN, OANA, SIMU, MIHAELA, BEDREAG, OVIDIU HOREA, MARINESCU, ILEANA, HUTANU, DELIA, ENĂTESCU, ILEANA, and NUSSBAUM, LAURA ALEXANDRA

Subjects
ALCOHOL withdrawal syndrome, CLONIDINE, ALCOHOLISM, BLOOD pressure, DRUG withdrawal symptoms
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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82. THE PRESENCE OF PERIPHERAL INFLAMMATORY MARKERS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER, THE ASSOCIATED SYMPTOMS PROFILES AND THE ANTIDEPRESSANT EFFICACY OF CELECOXIB.

Author

KALINOVIĆ, VIRGIL RADU ENĂTESCU RALUKA, VLAD, GABRIELA, NUSSBAUM, LAURA ALEXANDRA, HOGEA, LAVINIA, ENĂTESCU, ILEANA, MARINESCU, ILEANA, IFTENI, PETRU, SIMU, MIHAELA, MARIAN, CĂTĂLIN, GIURGI-ONCU, CĂTĂLINA, and PAPAVĂ, ION

Subjects
MENTAL depression, CELECOXIB, HAMILTON Depression Inventory, PATHOLOGY, ANTIDEPRESSANTS
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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83. STUDY ON TOLERABILITY AND EFFICACY OF PALIPERIDONE PALMITATE, OLANZAPINE PAMOATE AND RISPERIDONE LONG ACTING INJECTION IN A ROMANIAN SAMPLE OF PATIENTS WITH SCHIZOPHRENIA.

Author

ENĂTESCU, VIRGIL-RADU, DEHELEAN, CRISTINA ADRIANA, NUSSBAUM, LAURA ALEXANDRA, HOGEA, LAVINIA, HOMOROGAN, CLAUDIA, ENĂTESCU, ILEANA, PAPAVĂ, ION, MARINESCU, ILEANA, IFTENI, PETRU, SIMU, MIHAELA, CĂTĂLIN, MARIAN, GIURGI-ONCU, CĂTĂLINA, and SÎRBU, IOAN-OVIDIU

Subjects
RISPERIDONE, PEOPLE with schizophrenia, OLANZAPINE, PSYCHOSES, SOCIAL groups
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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84. EFFICACY, SAFETY AND PATIENT’S QUALITY OF LIFE OF LONG-TERM TREATMENT WITH LEVODOPA-CARBIDOPA INTESTINAL GEL IN ADVANCED PARKINSON’S DISEASE IN ROMANIA: RESULTS FROM GLORIA OBSERVATIONAL STUDY.

Author

Szasz, Jozsef, Simu, Mihaela, Perju-Dumbrava, Lacramioara, Antonini, Angelo, Bergmann, Lars, Popescu, Diana, and Bajenaru, Ovidiu Alexandru

Abstract

Objectives. The aim of the Global Long-Term Registry on Efficacy and Safety of DUODOPA in Patients with Advanced Parkinson’s Disease in Routine Care (GLORIA) was to document 24-month efficacy, safety and the effect on patient’s quality of life (QoL) of long-term treatment with levodopa-carbidopa intestinal gel (LCIG) in advanced Parkinson’s disease (PD) in routine clinical care. Here we present the results for the patients enrolled in Romania in the GLORIA registry. Material and methods. GLORIA registry is a multicenter, international, observational registry conducted between June 2010 and June 2015. In Romania, 39 patients with an indication for LCIG therapy were enrolled and followed for up to 24 months. Outcomes. During the study period LCIG led to significant improvements in “Off” time, “On” time with dyskinesia, activities of daily living (ADLs), motor examination, non-motor symptoms, and QoL which maintained up to the end of follow-up. At 24 months, “Off” time had a mean reduction of -5.2±3.1 hours/day vs. baseline (p < 0.0001) and “On” time with dyskinesia had a mean reduction of -3.5±3.3 hours/day vs. baseline (p < 0.0001). Both ADLs and motor examination “On” scores showed a maximum improvement at 6 months and 12 months (p < 0.0001) and remained significantly lower vs. baseline at 24 months (ADLs -6.6±8.7, p = 0.0023; motor examination -6.4±7.3, p = 0.0007). Non-motor symptoms scale (NMSS) total score had a mean reduction at 24 months of -18.29 as compared to baseline (p = 0.0011). QoL, as assessed by PDQ-8 significantly improved at 6 months as compared to baseline (p = 0.0141) and maintained its statistical significance until the 12 months evaluation (p = 0.0076). Adverse drug reactions possibly or probably related to the LCIG therapy were reported for 2.9% (1/35) of the patients during the temporary nasojejunal tube therapy and for 60.0% (21/35) of the patients during permanent tube phase. Conclusions. LCIG treatment showed significant and clinically relevant long-term improvements in motor symptoms and QoL in advanced PD patients. The safety/tolerability data confirmed the established safety profile. [ABSTRACT FROM AUTHOR]

Published
2020
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86. Comparative Study Using Progesterone and Gynipral - Hexoprenaline Sulphate, with Effects in Postpone Preterm Birth

Author

Hogea, Lavinia Maria, primary, Sas, Ioana Tuta, additional, Poroch, Vladimir, additional, Nussbaum, Laura Alexandra, additional, Sas, Ioan, additional, Serban, Denis, additional, Erdelean, Dragos, additional, Folescu, Roxana, additional, Zamfir, Carmen Lacramioara, additional, Bredicean, Ana Cristina, additional, and Simu, Mihaela Adriana, additional

Published
2018
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87. Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment

Author

Nussbaum, Laura Alexandra, primary, Hogea, Lavinia Maria, additional, Folescu, Roxana, additional, Grigoras, Mirela Loredana, additional, Zamfir, Carmen Lacramioara, additional, Boanca, Mihaela, additional, Erdelean, Dragos, additional, Rosca, Elena Cecilia Ildiko, additional, Nussbaum, Liliana, additional, Simu, Mihaela Adriana, additional, and Lupu, Viorel, additional

Published
2018
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88. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Author

Kappos, Ludwig, primary, Bar-Or, Amit, additional, Cree, Bruce A C, additional, Fox, Robert J, additional, Giovannoni, Gavin, additional, Gold, Ralf, additional, Vermersch, Patrick, additional, Arnold, Douglas L, additional, Arnould, Sophie, additional, Scherz, Tatiana, additional, Wolf, Christian, additional, Wallström, Erik, additional, Dahlke, Frank, additional, Achiron, Anat, additional, Achtnichts, Lutz, additional, Agan, Kadriye, additional, Akman-Demir, Gulsen, additional, Allen, Alison B, additional, Antel, Jack P, additional, Antiguedad, Alfredo Rodriguez, additional, Apperson, Michelle, additional, Applebee, Angela M, additional, Ayuso, Guillermo Izquierdo, additional, Baba, Masayuki, additional, Bajenaru, Ovidiu, additional, Balasa, Rodica, additional, Balci, Belgin Petek, additional, Barnett, Michael, additional, Bass, Ann, additional, Becker, Veit U, additional, Bejinariu, Mihaela, additional, Bergh, Florian Then, additional, Bergmann, Arnfin, additional, Bernitsas, Evanthia, additional, Berthele, Achim, additional, Bhan, Virender, additional, Bischof, Felix, additional, Bjork, Randall John, additional, Blevins, Gregg, additional, Boehringer, Matthias, additional, Boerner, Thomas, additional, Bonek, Robert, additional, Bowen, James D, additional, Bowling, Allen, additional, Boyko, Alexey N, additional, Boz, Cavit, additional, Bracknies, Vera, additional, Braune, Stefan, additional, Brescia Morra, Vincenzo, additional, Brochet, Bruno, additional, Brola, Waldemar, additional, Brownstone, Paul Kenneth, additional, Brozman, Miroslav, additional, Brunet, Donald, additional, Buraga, Ioan, additional, Burnett, Margaret, additional, Buttmann, Mathias, additional, Butzkueven, Helmut, additional, Cahill, Jonathan, additional, Calkwood, Jonathan C, additional, Camu, William, additional, Cascione, Mark, additional, Castelnovo, Giovani, additional, Centonze, Diego, additional, Cerqueira, Joao, additional, Chan, Andrew, additional, Cimprichova, Andrea, additional, Cohan, Stanley, additional, Comi, Giancarlo, additional, Conway, Jill, additional, Cooper, Joanna A, additional, Corboy, John, additional, Correale, Jorge, additional, Costell, Brian, additional, Cottrell, David A, additional, Coyle, Patricia K, additional, Craner, Matthew, additional, Cui, Liying, additional, Cunha, Luis, additional, Czlonkowska, Anna, additional, da Silva, Ana Martins, additional, de Sa, Joao, additional, de Seze, Jérôme, additional, Debouverie, Marc, additional, Debruyne, Jan, additional, Decoo, Danny, additional, Defer, Gilles, additional, Derfuss, Tobias, additional, Deri, Norma H, additional, Dihenia, Bhupesh, additional, Dioszeghy, Peter, additional, Donath, Vladimir, additional, Dubois, Benedicte, additional, Duddy, Martin, additional, Duquette, Pierre, additional, Edan, Gilles, additional, Efendi, Husnu, additional, Elias, Stanton, additional, Emrich, Peter J, additional, Estruch, Bonaventura Casanova, additional, Evdoshenko, Evgeniy P, additional, Faiss, Juergen, additional, Fedyanin, Alexander S, additional, Feneberg, Wolfgang, additional, Fermont, Jiske, additional, Fernandez, Oscar Fernandez, additional, Ferrer, Francisco Coret, additional, Fink, Katharina, additional, Ford, Helen, additional, Ford, Corey, additional, Francia, Ada, additional, Freedman, Mark, additional, Frishberg, Benjamin, additional, Galgani, Simonetta, additional, Garmany, George P, additional, Gehring, Klaus, additional, Gitt, Jeffrey, additional, Gobbi, Claudio, additional, Goldstick, Lawrence P, additional, Gonzalez, Rafael Arroyo, additional, Grandmaison, Francois, additional, Grigoriadis, Nikolaos, additional, Grigorova, Olga, additional, Grimaldi, Luigi Maria Edoardo, additional, Gross, Jeffrey, additional, Gross-Paju, Katrin, additional, Gudesblatt, Mark, additional, Guillaume, Daniel, additional, Haas, Judith, additional, Hancinova, Viera, additional, Hancu, Anca, additional, Hardiman, Orla, additional, Harmjanz, Arndt, additional, Heidenreich, Fedor R, additional, Hengstman, G J D, additional, Herbert, Joseph, additional, Herring, Mark, additional, Hodgkinson, Suzanne, additional, Hoffmann, Olaf M, additional, Hofmann, Werner E, additional, Honeycutt, William D, additional, Hua, Le Hanh, additional, Huang, Dehui, additional, Huang, Yining, additional, Huang, DeRen, additional, Hupperts, Raymond, additional, Imre, Piroska, additional, Jacobs, Alan Keith, additional, Jakab, Gabor, additional, Jasinska, Elzbieta, additional, Kaida, Kenichi, additional, Kalnina, Jolanta, additional, Kaprelyan, Ara, additional, Karelis, Guntis, additional, Karussis, Dimitrios, additional, Katz, Amos, additional, Khabirov, Farit A, additional, Khatri, Bhupendra, additional, Kimura, Takashi, additional, Kister, Ilya, additional, Kizlaitiene, Rasa, additional, Klimova, Eleonora, additional, Koehler, Juergen, additional, Komatineni, Aparna, additional, Kornhuber, Anselm, additional, Kovacs, Krisztina, additional, Koves, Agnes, additional, Kozubski, Wojciech, additional, Krastev, Georgi, additional, Krupp, Lauren B, additional, Kurca, Egon, additional, Lassek, Christoph, additional, Laureys, Guy, additional, Lee, Liesly, additional, Lensch, Eckart, additional, Leutmezer, Fritz, additional, Li, Hongzeng, additional, Linker, Ralf A, additional, Linnebank, Michael, additional, Liskova, Petra, additional, Llanera, Cristina, additional, Lu, Jiahong, additional, Lutterotti, Andreas, additional, Lycke, Jan, additional, Macdonell, Richard, additional, Maciejowski, Maciej, additional, Maeurer, Mathias, additional, Magzhanov, Rim V, additional, Maida, Eva-Maria, additional, Malciene, Lina, additional, Mao-Draayer, Yang, additional, Marfia, Girolama Alessandra, additional, Markowitz, Clyde, additional, Mastorodimos, Vasileios, additional, Matyas, Klotild, additional, Meca-Lallana, Jose, additional, Merino, Juan Antonio Garcia, additional, Mihetiu, Ioan Gheorghe, additional, Milanov, Ivan, additional, Miller, Aaron E, additional, Millers, Andrejs, additional, Mirabella, Massimiliano, additional, Mizuno, Masanori, additional, Montalban, Xavier, additional, Montoya, Lilina, additional, Mori, Masahiro, additional, Mueller, Stefanie, additional, Nakahara, Jin, additional, Nakatsuji, Yuji, additional, Newsome, Scott, additional, Nicholas, Richard, additional, Nielsen, A Scott, additional, Nikfekr, Esmaeil, additional, Nocentini, Ugo, additional, Nohara, Chiyoko, additional, Nomura, Kyoichi, additional, Odinak, Miroslav M, additional, Olsson, Tomas, additional, van Oosten, B W, additional, Oreja-Guevara, Celia, additional, Oschmann, Patrick, additional, Overell, James, additional, Pachner, Andrew, additional, Panczel, Gyula, additional, Pandolfo, Massimo, additional, Papeix, Caroline, additional, Patrucco, Liliana, additional, Pelletier, Jean, additional, Piedrabuena, Raul, additional, Pless, Misha, additional, Polzer, Udo, additional, Pozsegovits, Krisztian, additional, Rastenyte, Daiva, additional, Rauer, Sebastian, additional, Reifschneider, Gerd, additional, Rey, Roberto, additional, Rizvi, Syed A, additional, Robertson, Derrick, additional, Rodriguez, Jose Martinez, additional, Rog, David, additional, Roshanisefat, Homayoun, additional, Rowe, Vernon, additional, Rozsa, Csilla, additional, Rubin, Susan, additional, Rusek, Stanislaw, additional, Saccà, Francesco, additional, Saida, Takahiko, additional, Salgado, Antonio Vasco, additional, Sanchez, Victoria Eugenia Fernandez, additional, Sanders, Kalina, additional, Satori, Maria, additional, Sazonov, Denis V, additional, Scarpini, Elio Angelo, additional, Schlegel, Eugen, additional, Schluep, Myriam, additional, Schmidt, Stephan, additional, Scholz, Erich, additional, Schrijver, H M, additional, Schwab, Matthias, additional, Schwartz, Raymond, additional, Scott, James, additional, Selmaj, Krzysztof, additional, Shafer, Stuart, additional, Sharrack, Basil, additional, Shchukin, Ivan A, additional, Shimizu, Yuko, additional, Shotekov, Penko, additional, Siever, Arno, additional, Sigel, Karl-Otto, additional, Silliman, Scott, additional, Simo, Magdolna, additional, Simu, Mihaela, additional, Sinay, Vladimiro, additional, Siquier, Antonio Escartin, additional, Siva, Aksel, additional, Skoda, Ondrej, additional, Solomon, Andrew, additional, Stangel, Martin, additional, Stefoski, Dusan, additional, Steingo, Brian, additional, Stolyarov, Igor D, additional, Stourac, Pavel, additional, Strassburger-Krogias, Katrin, additional, Strauss, Erik, additional, Stuve, Olaf, additional, Tarnev, Ivaylo, additional, Tavernarakis, Antonios, additional, Tello, Cristina Ramo, additional, Terzi, Murat, additional, Ticha, Veronika, additional, Ticmeanu, Marina, additional, Tiel-Wilck, Klaus, additional, Toomsoo, Toomas, additional, Tubridy, Niall, additional, Tullman, Mark J, additional, Tumani, Hayrettin, additional, Turcani, Peter, additional, Turner, Ben, additional, Uccelli, Antonio, additional, Urtaza, Francisco Javier Olascoaga, additional, Vachova, Marta, additional, Valikovics, Attila, additional, Walter, Silke, additional, Van Wijmeersch, Bart, additional, Vanopdenbosch, Ludo, additional, Weber, Joerg R, additional, Weiss, Sara, additional, Weissert, Robert, additional, West, Timothy, additional, Wiendl, Heinz, additional, Wiertlewski, Sandrine, additional, Wildemann, Brigitte, additional, Willekens, Barbara, additional, Visser, L H, additional, Vorobeychik, Galina, additional, Xu, Xianhao, additional, Yamamura, Takashi, additional, Yang, Yi N, additional, Yelamos, Sergio Martinez, additional, Yeung, Michael, additional, Zacharias, Alan, additional, Zelkowitz, Marvin, additional, Zettl, Uwe, additional, Zhang, Meini, additional, Zhou, Hongyu, additional, Zieman, Ulf, additional, and Ziemssen, Tjalf, additional

Published
2018
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90. Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack

Author

Johnston, S Claiborne, Amarenco, Pierre, Albers, Gregory W, Denison, Hans, Easton, J Donald, Evans, Scott R, Held, Peter, Jonasson, Jenny, Minematsu, Kazuo, Molina, Carlos A, Wang, Yongjun, Wong, K S Lawrence, Ameriso, Sebastiá F, Donnan, Geoffrey, Lemmens, Robin, Massaro, Ayrton, Titianova, Ekaterina, Hill, Michael D, Lavados, Pablo, Skoloudik, David, Röther, Joachim, Norbert, Szegedi, Agnelli, Giancarlo, Bornstein, Natan, Tanahashi, Norio, Góngora, Angel Arauz, Pretell, Edwin, San Jose, Maria Cristina Z, Czlonkowska, Anna, Bajenaru, Ovidiu, Stakhovskaya, Ludmila, Brozman, Miroslav, Kim, Jong-Sung, Wahlgren, Nils, Michel, Patrik, Lee, Tsong Hai, Suwanwela, Nijasri Charnnarong, Kutluk, Kursad, Moskovko, Sergii, Kasner, Scott, Laskowitz, Daniel, Clark, Wayne, Nguyen, Huy Thang, Ameriso, Sebastián F, Ameriso, Sebastian, Lepera, Sandra, Romano, Marina, Paulon, David, Ioli, Pablo, Zurru, Cristina, Bruera, Guadalupe, Jure, Lorena, Klein, Francisco, Povedano, Guillermo, Levi, Christopher, Phan, Thanh, Markus, Romesh, Anderson, Craig, Sabet, Arman, Davis, Stephen, Lee, Andrew, Kleinig, Timothy, Wong, Andrew, Krause, Martin, Jannes, Jim, Wijeratne, Tissa, Hemelsoet, Dimitri, Peeters, André, Tack, Philippe, Vanacker, Peter, Laloux, Patrice, Van Landegem, William, Vanhooren, Geert, Desfontaines, Philippe, Van Orshoven, Marc, Oliveira, Fabio, Friedrich, Mauricio, Brondani, Rosane, Gagliardi, Rubens, Fabio, Soraia, Dracoulakis, Marianna, Bazan, Rodrigo, Marrone, Luiz, Pontes Neto, Octavio, Silva, Gisele, Kowacs, Pedro, Stamenova, Paraskeva, Daskalov, Marin, Staikov, Ivan, Baldaranov, Dimo, Maslarov, Dimitar, Lilovski, Hristo, Petkov, Plamen, Petrova, Neli, Mavrov, Radoslav, Markova, Veska, Petrova, Valeria, Beleva, Tanya, Kralev, Borislav, Sotirov, Nikolay, Lekova, Veska, Hristov, Dimcho, Ermenkova, Vera, Mateev, Lyudmil, Mitkova, Rumeliya, Haralanov, Liybomir, Ikonomov, Rosen, Mihailova, Margarita, Georgiev, Ivan, Shuaib, Ashfaq, Hachinski, Vladimir, Boulanger, Jean-Martin, Mann, Sharan, Hassan, Ayman, Mackey, Ariane, Menon, Bijoy, Minuk, Jeffrey, Siddiqui, Muzaffar, Eustace, Marsha, Vieira, Lucia, Selchen, Daniel, Beaudry, Michel, Stotts, Grant, Castro, Angel, Gasic, Kristo, Rivas, Rodrigo, Sanchez, Pablo, Roldan, Andres, Grossmann, Ingrid, Figueroa, Christian, Li, Jimei, Xu, Xiaolin, Chen, Huisheng, Li, Xiaohong, Yang, Yi, Zhang, Chunsheng, Wang, Baojun, Li, Guanglai, Wang, Dong, Lin, Hong, Tang, Yamei, Xu, Anding, Wang, Yanjiang, Hong, Wenke, Song, Zhi, Zhang, Xu, Jin, Xiaoping, Xu, Yun, Yan, Fuling, Zheng, Weihong, Wang, Xiaoping, Dong, Qiang, Zhao, Zhongxin, Zhang, Baorong, Zhong, Wangtao, Wen, Guoqiang, Xu, Jun, Li, Guozhong, Dong, Xueshuang, Tian, Xiangyang, Zhang, Zhaohui, Xu, En, Liu, Kaixiang, Chen, Jun, Skoda, Ondrej, Ehler, Edvard, Vaclavik, Daniel, Sanak, Daniel, Klimosova, Sylva, Vitkova, Eva, Fiksa, Jan, Mikulik, Robert, Neumann, Jiri, Plny, Richard, Leys, Didier, Sibon, Igor, Mas, Jean-Louis, Alamowitch, Sonia, Pico, Fernando, Hosseini, Hassan, Mahagne, Marie-Hélène, Touze, Emmanuel, Vadot, Wilfried, Vannier, Stéphane, Nighoghossian, Norbert, Samson, Yves, Garnier, Pierre, Ellie, Emmanuel, Guillon, Benoît, Timsit, Serge, Giroud, Maurice, Philippeau, Frédéric, Bagan-Triquenot, Aude, Wolff, Valérie, Raposo, Nicolas, Obadia, Michel, Debiais, Severine, Grimaud, Jérôme, Illouz, Stéphane, Smadja, Didier, Urbanczyk, Cédric, Berrouschot, Jörg, Weimar, Christian, Gahn, Georg, Soda, Hassan, Klimpe, Sven, Nabavi, Darius, Glahn, Jörg, Köhrmann, Martin, Krause, Lars, Terborg, Christoph, Urban, Peter, Steiner, Thorsten, Ferbert, Andreas, Dziewas, Rainer, Seidel, Günter, Thomalla, Götz, Wong, Ka Sing Lawrence, Li, Richard, Fong, Wing Chi, Cheung, Raymond, Szegedi, Norbert, Pozsegovits, Krisztián, Valikovics, Attila, Pánczél, Gyula, Rózsa, Csilla, Németh, László, Diószeghy, Péter, Óváry, Csaba, Csányi, Attila, Kerényi, Levente, Nagy, Valéria, Komoly, Sámuel, Bereczki, Dániel, Molnár, Sándor, Kondákor, István, Tanne, David, Raphaeli, Guy, Telman, Gregory, Leker, Ronen, Lampl, Yair, Corea, Francesco, Ricci, Stefano, Guidetti, Donata, Malferrari, Giovanni, Marcheselli, Simona, Micieli, Giuseppe, Zini, Andrea, Di Lazzaro, Vincenzo, Gandolfo, Carlo, Salmaggi, Andrea, Tassi, Rossana, Rasura, Maurizia, Orlandi, Giovanni, Comi, Giancarlo, Mancuso, Michelangelo, Delodovici, Marialuisa, Bovi, Paolo, Consoli, Domenico, Utsugisawa, Kimiaki, Fujita, Tsuneo, Kurihara, Hideyuki, Maruki, Chikashi, Hayashi, Takeshi, Ogiichi, Tsuneaki, Kumagai, Morio, Takenaka, Katsunobu, Toyoda, Kazunori, Takamatsu, Kazuhiro, Ogami, Ryo, Kin, Shigenari, Aoki, Takeshi, Takizawa, Katsumi, Omori, Shigehiro, Umezawa, Takehiko, Toba, Yasuyuki, Nonoyama, Yutaka, Nakagawa, Hidemitsu, Naka, Takashi, Morimoto, Masanori, Matsumoto, Shuichi, Hitotsumatsu, Tsutomu, Shingaki, Tatsuya, Okuda, Satoshi, Ota, Mamoru, Sakai, Nobuyuki, Yamada, Takeshi, Niwa, Jun, Fujita, Hitoshi, Moriki, Akihito, Yoshino, Kimihiro, Fukushima, Yoshihisa, Mori, Takahisa, Sato, Atsushi, Kusano, Yoshikazu, Kubo, Michiya, Yamazaki, Masashi, Ooasa, Takao, Nishizaki, Takafumi, Kitagawa, Naoki, Yasaka, Masahiro, Manabe, Yasuhiro, Yoshioka, Akira, Ishihara, Masayuki, Kagawa, Takato, Ichihashi, Toshikazu, Matsuoka, Hideki, Ito, Yasuhiro, Yamasaki, Masahiro, Takaba, Hitonori, Saito, Hisatoshi, Sato, Masahiro, Fukuda, Kazumasa, Endo, Sumio, Kidooka, Minoru, Umemura, Toshitaka, Kikkawa, Yuriko, Toru, Shuta, Yamada, Kentaro, Sakai, Hideki, Asari, Jun, Ezura, Masayuki, Nitta, Hisashi, Nagano, Keiko, Ochiai, Jun, Sakai, Keiichi, Kobayashi, Yasutaka, Yoshii, Yasuhiro, Miake, Hirotomo, Takita, Tomohiro, Taniguchi, Hidekazu, Kuroki, Kazuhiko, Mizota, Takamitsu, Yamamoto, Kenichi, Nakane, Hiroshi, Iwanaga, Takeshi, Chiba, Kei, Yoshimoto, Tetsuyuki, Torii, Tsuyoshi, Kitagawa, Takeo, Takashima, Hiroshi, Shirasaki, Naoki, Dehara, Makoto, Wada, Naomichi, Hamada, Kensuke, Kato, Noriyuki, Go, Yoshinori, Izumi, Ichiro, Ninomiya, Hirotomo, Kumai, Junichiro, Nakajima, Yoshikazu, Kaku, Yasuhiko, Isayama, Yukihiro, Kawanishi, Masahiro, Noda, Shinya, Yamamoto, Kazuhide, Hazama, Takanori, Takahashi, Hiroshi, Tanaka, Yohei, Hata, Takashi, Kazekawa, Kiyoshi, Furui, Eisuke, Hondo, Hideki, Sato, Nobuyuki, Kusunoki, Katsusuke, Nanri, Kazunori, Abe, Satoshi, Sasaoka, Noboru, Kuroyanagi, Takayuki, Suzuki, Hisahiko, Fukuyama, Kouzou, Nakahara, Kimihiro, Gongora, Fernando, Brito, Carlos Cantú, Careaga, Jorge Villarreal, Alfaro, Rosalia Vazquez, Leytte, Geronimo Aguayo, Berrospi, Percy, Chavez, Carlos, Rodriguez, Liliana, Custodio, Nilton, Castañeda, Cesar, Perez, Julio, Marquez, Sandra Vargas, San Jose, Maria Cristina, Baroque, Alejandro, Collantes, Ma Epifania, Aquino, Abdias, Díaz, Alejandro, Roxas, Artemio, Lokin, Johnny, Advincula, Joel, Calderon, Emerito, Navarro, Jose, Hiyadan, John, Surdilla, Arturo, Ryglewicz, Danuta, Krychowiak, Grzegorz, Fryze, Waldemar, Sobolewski, Piotr, Nowak, Ryszard, Fiszer, Urszula, Papierowska, Beata, Zieli?ska-Turek, Justyna, Lasek-Bal, Anetta, Ko?odziejska, Ewa, Kami?ska, Anna, Adamkiewicz, Bo?ena, Tutaj, Andrzej, Szkopek, Dorota, Musiatowicz, Krzysztof, B?k, Zbigniew, Brzozowski, S?awomir, Brola, Waldemar, Ferens, Antoni, Zalisz, Marek, Rejdak, Konrad, Rudzi?ska, Monika, Panea, Cristina, Simu, Mihaela, Balasa, Rodica, Cuciureanu, Iulian, Popescu, Bogdan, Sabau, Monica, Roman-Filip, Corina, Stakhovskaya, Liudmila, Pimenov, Leonid, Gekht, Alla, Milto, Anna, Shchukin, Ivan, Parfenov, Vladimir, Arkhipov, Mikhail, Vishneva, Elena, Sokolova, Nadezhda, Bogdanov, Enver, Esin, Radiy, Khasanova, Dina, Golikov, Konstantin, Melnikova, Elena, Zaslavskiy, Leonid, Voznyuk, Igor, Nazarov, Alexander, Akhmadeeva, Leila, Iakupova, Aida, Shamalov, Nikolay, Belskaya, Galina, Chuprina, Svetlana, Denisova, Olga, Drozdova, Ekaterina, Karakulova, Yuliya, Sholomov, Ilya, Spirin, Nikolay, Vostrikova, Elena, Mordvintseva, Elena, Grigoryeva, Vera, Zateyshchikov, Dmitry, Gorbachev, Vladimir, Chefranova, Zhanna, Dudarev, Mikhail, Nilk, Rostislav, Rozhdestvenskiy, Alexey, Gurcik, Ladislav, Dvorak, Miloslav, Krastev, Georgi, Kurca, Egon, Vyletelka, Juraj, Kim, Jong Sung, Bae, Hee-Joon, Kim, Yong-Won, Kim, Joon-Tae, Cha, Jae-Kwan, Nam, Hyo Suk, Chang, Dae-Il, Lee, Yong-Seok, Oh, Kyungmi, Yu, Sung-Wook, Sohn, Sung-Il, Lee, Jun, Cho, Han Jin, Kim, Eung-Gyu, Rha, Joung-Ho, Kim, Seo Hyun, Cateriano, Carlos Molina, Leal, Joaquín Serena, Mora, José Vivancos, Yañez, Manuel Rodríguez, González, Jaume Roquer, García, Francisco Purroy, Cortina, Meritxell Gomis, Vallejo, Jaime Masjuan, Lara, Juan Arenillas, Martín, Tomás Segura, Herrero, José Antonio Egido, Ferrairó, Jose Ignacio Tembl, Culleré, Jaime Gállego, Álvarez, Francisco Moniche, Steinberg, Anna, Callander, Margarita, Laska, Ann Charlotte, Bokemark, Lena, Mooe, Thomas, Käll, Tor-Björn, Welin, Lennart, Sjöblom, Lars, Hambraeus, Joakim, Teichert, Jörg, Wannberg, Hans, Sanner, Johan, Ramströmer, Bo, Ziedén, Bo, Hau, Stefan Olsson, Gustafsson, Claes, Kahles, Timo, Lyrer, Philippe, Arnold, Marcel, Liesch, Martin, Medlin, Friedrich, Cereda, Carlo, Kägi, Georg, Luft, Andreas, Carrera, Emmanuel, Lee, Tsong-Hai, Po, Helen L, Chern, Chang-Ming, Lien, Li-Ming, Chan, Lung, Liu, Chung-Hsiang, Wu, Shey-Lin, Lee, Jiann-Der, Chen, Chih-Hung, Lin, Huey-Juan, Lin, Ruey-Tay, Chen, Wei-Hsi, Sun, Yu, Tantirittisak, Tasanee, Muengtaweepongsa, Sombat, Nilanont, Yongchai, Tiamkao, Somsak, Udommongkol, Chesda, Watcharasaksilp, Kanokwan, Jantararotai, Witoon, Sirin, Hadiye, Ince, Birsen, Asil, Talip, Arsava, Murat, Incesu, Tulay Kurt, Tireli, Hulya, Kucukoglu, Hayriye, Ak, Fikri, Unal, Ali, Ozturk, Serefnur, Uzuner, Nevzat, Chmyr, Galyna, Lebedynets, Volodymyr, Nikonov, Vadym, Shulga, Lyudmyla, Smolanka, Volodymyr, Khavunka, Marta, Yavorska, Valentyna, Tomakh, Nataliya, Kozyolkin, Olexandr, Litovaltseva, Galyna, Lansberg, Maarten, Bernstein, Richard, Brown, David, Dissin, Jonathan, Graffagnino, Carmelo, Harris, Jonathan, Hicks, William, Katzan, Irene, Kramer, Jeffrey, Willey, Joshua, Silliman, Scott, Starkman, Sidney, Thaler, David, Tremwel, Margaret, Concha, Mauricio, Rajamani, Kumar, Dandapani, Bhuvaneswari, Silver, Brian, Deal, Nathan, Chang, Ira, Hassan, Ameer, Rudolph, Steven, Fischer, Kenneth, Kirshner, Howard, Logan, William, Mallenbaum, Sidney, Hefzy, Hebah, Latorre, Julius, Levine, Steven, Ciabarra, Anthony, Dafer, Rima, Anyanwu, Benjamin, Cherian, Laurel, Panezai, Spozhmy, Khanna, Anna, Dodds, Jodi, Torbey, Michel, Gebel, James, Woo, Henry, Chiu, David, Androulakis, Xiao, Burgin, William, Pineda, Maria, Yilmaz, Engin, Altafullah, Irfan, Boutwell, Christine, Cruz-Flores, Salvador, Sapkota, Biggya, Fayad, Pierre, Jacoby, Michael, Rafiq, Shahid, Salgado, Efrain, Lafranchise, Eugene, Felton, Warren, Madhavan, Ramesh, Zaidat, Osama, Pieper, Connie, Riviello, Ralph, Burnett, Aaron, Fischer, Michelle, Gentile, Nina, Calder, Christopher, Dietrich, Dennis, Cross, Jonathan, Blankenship, Larry, Montoya, Liliana, Grogan, Wendell, Young, Mark, Khan, Farrukh, Campbell, Duane, Daboul, Nizar, Espinoza, Andrey, Cullis, Paul, Concepcion, Gilberto, Wulff, John, Afzal, Haider, Jaffrani, Naseem, Reiter, William, Arshad, Tamjeed, Lukovits, Timothy, Welker, James, Chang, Fen Lei, Badruddin, Aamir, Babikian, Viken, Menon, Ravi, Sander, James, Springer, Mellanie, Nanda, Ashish, Mas, Luis, Rajan, Raj, Silverman, Bruce, Huang, David, Carpenter, David, Clark, Joni, Ching, Marilou, Santhakumar, Sunitha, Gould, Jeffrey, Bansal, Vibhav, Vidal, Gabriel, Mikesell, Timothy, Brick, John, French, William, Shah, Qaisar, Holmstedt, Christine, Ishag-Osman, Nadir, Kostis, John, Shehadeh, Abbas, Sethi, Pramodkumak, Imam, Asher, Mccomas, Carl, Tran, Duc, Gebreyohanns, Mehari, Wiseman, Brian, Malik, Maheen, Schwarcz, Aron, Altschul, Dorothea, Castaldo, John, Alshekhlee, Amer, Gancher, Stephen, Krish, Nagesh, Nguyen-Huynh, Mai, Tremwell, Margaret, Sharma, Jitendra, Lee, Lance, Neil, William, Siddiqui, Fazeel, Malek, Ali, Romero, Charles, Huy, Thang Nguyen, Hoang, Hoa, Nguyen, Thang, Nguyen, Anh, Nguyen, Hung, Dean's Office (DO - AUSTIN), University of Texas at Austin [Austin], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Bichat - Claude Bernard, Stanford Stroke Center, Stanford University Medical Center, AstraZeneca, Harvard T.H. Chan School of Public Health, National Cerebral and Cardiovascular Center (NCCC - OSAKA), Osaka University [Osaka], Stroke Unit (SU - BARCELONE), Vall d'Hebron University Hospital [Barcelona], Department of Neurology (Dep Neuro - BEIJING), Tiantan Hospital, Department of Medicine and Therapeutics [Hong Kong], The Chinese University of Hong Kong [Hong Kong], Murdoch University, Service de Neurologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, Ticagrelor, Adenosine, Medizin, Aged, Aspirin, Double-Blind Method, Female, Hemorrhage, Humans, Ischemic Attack, Transient, Kaplan-Meier Estimate, Middle Aged, Platelet Aggregation Inhibitors, Purinergic P2Y Receptor Antagonists, Stroke, Medicine (all), 030204 cardiovascular system & hematology, Stringa autori originale: Johnston SC, Easton JD, 0302 clinical medicine, Myocardial infarction, Ischemic Attack, Transient, General Medicine, Clopidogrel, Denison H, 3. Good health, Minematsu K, Wang Y, SOCRATES Steering Committee and Investigators. - Free full-text sul sito dell'editore, Anesthesia, Platelet aggregation inhibitor, Evans SR, medicine.drug, Stringa autori originale: Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS, Ischemia, Loading dose, Molina CA, 03 medical and health sciences, medicine, business.industry, Jonasson J, medicine.disease, Albers GW, Amarenco P, Held P, Wong KS, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia.; We conducted an international double-blind, controlled trial in 674 centers in 33 countries, in which 13,199 patients with a nonsevere ischemic stroke or high-risk transient ischemic attack who had not received intravenous or intraarterial thrombolysis and were not considered to have had a cardioembolic stroke were randomly assigned within 24 hours after symptom onset, in a 1:1 ratio, to receive either ticagrelor (180 mg loading dose on day 1 followed by 90 mg twice daily for days 2 through 90) or aspirin (300 mg on day 1 followed by 100 mg daily for days 2 through 90). The primary end point was the time to the occurrence of stroke, myocardial infarction, or death within 90 days.; During the 90 days of treatment, a primary end-point event occurred in 442 of the 6589 patients (6.7%) treated with ticagrelor, versus 497 of the 6610 patients (7.5%) treated with aspirin (hazard ratio, 0.89; 95% confidence interval [CI], 0.78 to 1.01; P=0.07). Ischemic stroke occurred in 385 patients (5.8%) treated with ticagrelor and in 441 patients (6.7%) treated with aspirin (hazard ratio, 0.87; 95% CI, 0.76 to 1.00). Major bleeding occurred in 0.5% of patients treated with ticagrelor and in 0.6% of patients treated with aspirin, intracranial hemorrhage in 0.2% and 0.3%, respectively, and fatal bleeding in 0.1% and 0.1%.; In our trial involving patients with acute ischemic stroke or transient ischemic attack, ticagrelor was not found to be superior to aspirin in reducing the rate of stroke, myocardial infarction, or death at 90 days. (Funded by AstraZeneca; ClinicalTrials.gov number, NCT01994720.).

Published
2016
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91. Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry

Author

Antonini, Angelo, primary, Poewe, Werner, additional, Chaudhuri, K. Ray, additional, Jech, Robert, additional, Pickut, Barbara, additional, Pirtošek, Zvezdan, additional, Szasz, Jozsef, additional, Valldeoriola, Francesc, additional, Winkler, Christian, additional, Bergmann, Lars, additional, Yegin, Ashley, additional, Onuk, Koray, additional, Barch, David, additional, Odin, Per, additional, Amalia, Ene, additional, Arnold, Guy, additional, Bajenaru, Ovidiu, additional, Bergmans, Bruno, additional, Bjornara, Kari Anne, additional, Blackie, Jeff, additional, Bode, Matthias, additional, Bourgeois, Paul, additional, Bohlhalter, Stephan, additional, Buraga, Ioan, additional, Burkhard, Pierre R., additional, Busson, Philippe, additional, Calopa, Matilde, additional, Clausen, Jesper, additional, Danielsen, Erik Hvid, additional, Defebvre, Luc, additional, Delvaux, Valerie, additional, Dethy, Sophie, additional, Dietrichs, Espen, additional, De Fabregues, Oriol, additional, Gerhard, Ransmayr, additional, Gusmaroli, Graziano, additional, Hahn, Kirsten, additional, Hauptmann, Björn, additional, Henriksen, Tove, additional, Hernandez-Vara, Jorge, additional, Jeanjean, A., additional, Kaiserova, Michaela, additional, Kassubek, Jan, additional, Kimber, Thomas, additional, Konitsiotis, Spyridon, additional, Krüger, Rejko, additional, Kulisevsky, Jaime, additional, Leenders, Jo, additional, Lundqvist, Christofer, additional, Ory Magne, F., additional, Marano, Pietro, additional, Milanov, Ivan, additional, Modugno, Nicola, additional, Misbahuddin, Anjum, additional, Nevrly, Martin, additional, Panayiotis, Zikos, additional, Pedersen, Kenn Freddy, additional, Pedersen, Stephen W., additional, Perju-Dumbrava, Lacramioara, additional, Ponsen, M.M., additional, Popescu, Bogdan O., additional, Rijntjes, Michel, additional, Puente, V., additional, Redecker, Christoph, additional, Schrader, Christoph, additional, Sensi, Mariachiara, additional, Simu, Mihaela, additional, Spanaki, Cleanthe, additional, Storch, Alexander, additional, Storstein, Anette, additional, Tomantschger, Volker, additional, van der Linden, Chris, additional, van Laar, T., additional, Viallet, F., additional, Witjas, Tatiana, additional, Wolz, Martin, additional, Zibetti, Maurizio, additional, and Van Zandijcke, Michel, additional

Published
2017
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92. The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis

Author

Gadalean, Florica, primary, Simu, Mihaela, additional, Parv, Florina, additional, Vorovenci, Ruxandra, additional, Tudor, Raluca, additional, Schiller, Adalbert, additional, Timar, Romulus, additional, Petrica, Ligia, additional, Velciov, Silvia, additional, Gluhovschi, Cristina, additional, Bob, Flaviu, additional, Mihaescu, Adelina, additional, Timar, Bogdan, additional, Spasovski, Goce, additional, and Ivan, Viviana, additional

Published
2017
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95. Age as an independent factor for the development of neuropathy in diabetic patients

Author

Popescu,Simona, Timar,Bogdan, Baderca,Flavia, Simu,Mihaela-Adriana, Diaconu,Laura, Velea,Iulian, Timar,Romulus, Popescu,Simona, Timar,Bogdan, Baderca,Flavia, Simu,Mihaela-Adriana, Diaconu,Laura, Velea,Iulian, and Timar,Romulus

Abstract

Simona Popescu,1,2 Bogdan Timar,2,3 Flavia Baderca,4,5 Mihaela Simu,6,7 Laura Diaconu,1,2 Iulian Velea,8,9 Romulus Timar1,2 12nd Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, 2Clinic of Diabetes, Nutrition and Metabolic Diseases, Emergency Clinical County Hospital, 3Department of Functional Sciences, 4Department of Microscopic Morphology, “Victor Babes” University of Medicine and Pharmacy, 5Service of Pathology, Emergency City Hospital, 6Department of Neurosciences, “Victor Babes” University of Medicine and Pharmacy, 7Clinic of Neurology, Emergency Clinical County Hospital, 8Department of Pediatrics, “Victor Babes” University of Medicine and Pharmacy, 9Clinic of Pediatrics, Emergency Clinical County Hospital, Timisoara, Romania Abstract: Population aging is unprecedented, without parallel in the history of humanity. As type 2 diabetes mellitus is predominantly more prevalent in aging populations, this creates a major public health burden. Older adults with diabetes have the highest rates of major lower-extremity amputation, myocardial infarction, visual impairment, and end-stage renal disease of any age group. The aims of our study were to assess whether age is an independent factor for the occurrence of diabetic neuropathy (DN), and to evaluate the relationship between the presence and the severity of DN and the diabetes duration and blood glucose level. In this study, we enrolled 198 patients, previously diagnosed with type 2 diabetes mellitus. For all patients, we measured hemoglobin A1c (HbA1c), lipid profile, and body mass index and we assessed the presence and severity of DN using the evaluation of clinical signs and symptoms. Patients had a median age of 62 years, with a median of diabetes duration of 7 years; 55.1% of the patients were men and the average HbA1c in the cohort was 8.2%. The prevalence of DN according to Michigan Neuropathy Scr

Published
2016

96. MP200THE IMPACT OF ACUTE KIDNEY INJURY ON IN-HOSPITAL MORTALITY IN ACUTE ISCHEMIC STROKE PATIENTS UNDERGOING INTRAVENOUS THROMBOLYSIS

Author

Gadalean, Florica, primary, Simu, Mihaela, additional, Joikits, Ruxandra, additional, Parv, Florina, additional, Marc, Luciana, additional, Petrica, Ligia, additional, Timar, Romulus, additional, Bob, Flaviu, additional, Mihaescu, Adelina, additional, Timar, Bogdan, additional, and Schiller, Adalbert, additional

Published
2016
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