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Coccidioidomycotic osteomyelitis developed at the angle of the right side of the mandible in a 5-month-old Papago infant. The disease was successfully treated with a combination of amphotericin B, surgery, and transfer factor with complete immunological, microbiological, and radiological cure. At 4 years of age, the only residual effect is prominence of the right hemimandible with asymmetry of the jaw.

Various genetic models were examined with regard to the control of the antibody response in rats. Distributions of the response to poly(Glu52Lys33Tyr15) were determined in the inbred ACI (high responder) and F344 (low responder) strains and in the F1, F2 and backcross generations. Falconer's test for the effective number of genes showed that there was a larger number of genes involved if the maternal parent were the high responder strain. Studies in mating combinations involving high and moderate responders showed that the effective number of genes influencing the antibody response was much lower than in the mating between the high and low responders. Theoretical distributions of antibody response levels were generated using Monte Carlo techniques. The Kolmogorov-Smirnov goodness-of-fit test indicated that a three-gene model best fitted the matings involving the ACI female and that a two-gene model best fitted the matings involving the F344 female. These calculations indicate that the antibody response is a complex, multifactorial trait whose expression is significantly affected by the responder status of the maternal strain.

It is generally believed that bacteremia rarely occurs with enteric Shigella infections. During a five-year period, 110 children were admitted to the University Hospital of the Arizona Health Sciences Center, Tucson, with Shigella enteritis. Eight (7%) had Shigella bacteremia/septicemia, and four of the eight died. An analysis of these patients and their course disclosed clinical characteristics that were of potential prognostic importance. Some of these indicators are identifiable early and hence could be useful in management. The patients at greatest risk were afebrile; 10% or more dehydrated; malnourished, with a low serum albumin level; infected with ampicillin-resistant strains; had leukopenia during the course of the illness; and had persistent watery hemoglobin-positive stools.

As a result of national surveys of occupational health and safety conditions in the American workplace, the National Institute for Occupational Safety and Health (NIOSH) has collected data on the provision of health care to workers as a consequence of their employment. Two of these surveys, initiated in 1972 and 1981, permit a preliminary examination of the trends in worker access to such care. This paper presents data on the provision of some aspects of medical care to workers in manufacturing and nonmanufacturing facilities as a result of employment. Among the principal findings are increases in general health care provided to workers, increased use of off-site physicians, and increased use of screening examinations or tests. Other analyses indicate a decreased use of on-site physicians and pre-employment examinations and decreased industrial retention of health information on new employees.