Search

Your search keyword '"Shen, Jianfeng"' showing total 928 results
Start Over Author "Shen, Jianfeng"
928 results on '"Shen, Jianfeng"'

55. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Author

Shen, Jianfeng, Peng, Yang, Wei, Leizhen, Zhang, Wei, Yang, Lin, Lan, Li, Kapoor, Prabodh, Ju, Zhenlin, Mo, Qianxing, Shih, Ie-Ming, Uray, Ivan P, Wu, Xiangwei, Brown, Powel H, Shen, Xuetong, Mills, Gordon B, and Peng, Guang

Subjects
Rare Diseases, Cancer, Clinical Research, Human Genome, Genetics, 2.1 Biological and endogenous factors, Aetiology, Animals, Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, DNA-Binding Proteins, Female, HCT116 Cells, Humans, Lung Neoplasms, Male, Mice, Nuclear Proteins, Poly(ADP-ribose) Polymerase Inhibitors, Transcription Factors, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis
Abstract

UnlabelledARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of fundamental clinical importance to understand its molecular functions and determine whether ARID1A deficiency can be exploited therapeutically. In this article, we report a key function of ARID1A in regulating the DNA damage checkpoint. ARID1A is recruited to DNA double-strand breaks (DSB) via its interaction with the upstream DNA damage checkpoint kinase ATR. At the molecular level, ARID1A facilitates efficient processing of DSB to single-strand ends and sustains DNA damage signaling. Importantly, ARID1A deficiency sensitizes cancer cells to PARP inhibitors in vitro and in vivo, providing a potential therapeutic strategy for patients with ARID1A-mutant tumors.SignificanceARID1A has been identified as one of the most frequently mutated genes across human cancers. Our data suggest that clinical utility of PARP inhibitors might be extended beyond patients with BRCA mutations to a larger group of patients with ARID1A-mutant tumors, which may exhibit therapeutic vulnerability to PARP inhibitors.

Published
2015

62. Long-read sequencing reveals alternative splicing-driven, shared immunogenic neoepitopes regardless SF3B1 status in uveal melanoma

Author

Yao, Tengteng, primary, Zhang, Zhe, additional, Li, Qian, additional, Huang, Rui, additional, Hong, Yanhong, additional, Li, Chen, additional, Zhang, Feng, additional, Huang, Yingying, additional, Fang, Yan, additional, Cao, Qin, additional, Jin, Xiaoliang, additional, Li, Chunliang, additional, Wang, Zefeng, additional, Lin, Xinhua (James), additional, Li, Lingjie, additional, Wei, Wu, additional, Wang, Zhaoyang, additional, and Shen, Jianfeng, additional

Published
2023
Full Text
View/download PDF

85. Data from Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

Author

Liang, Jiyong, primary, Wang, Lulu, primary, Wang, Chao, primary, Shen, Jianfeng, primary, Su, Bojin, primary, Marisetty, Anantha L., primary, Fang, Dexing, primary, Kassab, Cynthia, primary, Jeong, Kang Jin, primary, Zhao, Wei, primary, Lu, Yiling, primary, Jain, Abhinav K., primary, Zhou, Zhicheng, primary, Liang, Han, primary, Sun, Shao-Cong, primary, Lu, Changming, primary, Xu, Zhi-Xiang, primary, Yu, Qinghua, primary, Shao, Shan, primary, Chen, XiaoHua, primary, Gao, Meng, primary, Claret, Francois X., primary, Ding, Zhiyong, primary, Chen, Jian, primary, Chen, Pingsheng, primary, Barton, Michelle C., primary, Peng, Guang, primary, Mills, Gordon B., primary, and Heimberger, Amy B., primary

Published
2023
Full Text
View/download PDF

86. Figure S4 from Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

Author

Liang, Jiyong, primary, Wang, Lulu, primary, Wang, Chao, primary, Shen, Jianfeng, primary, Su, Bojin, primary, Marisetty, Anantha L., primary, Fang, Dexing, primary, Kassab, Cynthia, primary, Jeong, Kang Jin, primary, Zhao, Wei, primary, Lu, Yiling, primary, Jain, Abhinav K., primary, Zhou, Zhicheng, primary, Liang, Han, primary, Sun, Shao-Cong, primary, Lu, Changming, primary, Xu, Zhi-Xiang, primary, Yu, Qinghua, primary, Shao, Shan, primary, Chen, XiaoHua, primary, Gao, Meng, primary, Claret, Francois X., primary, Ding, Zhiyong, primary, Chen, Jian, primary, Chen, Pingsheng, primary, Barton, Michelle C., primary, Peng, Guang, primary, Mills, Gordon B., primary, and Heimberger, Amy B., primary

Published
2023
Full Text
View/download PDF

87. Table S1 from Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

Author

Liang, Jiyong, primary, Wang, Lulu, primary, Wang, Chao, primary, Shen, Jianfeng, primary, Su, Bojin, primary, Marisetty, Anantha L., primary, Fang, Dexing, primary, Kassab, Cynthia, primary, Jeong, Kang Jin, primary, Zhao, Wei, primary, Lu, Yiling, primary, Jain, Abhinav K., primary, Zhou, Zhicheng, primary, Liang, Han, primary, Sun, Shao-Cong, primary, Lu, Changming, primary, Xu, Zhi-Xiang, primary, Yu, Qinghua, primary, Shao, Shan, primary, Chen, XiaoHua, primary, Gao, Meng, primary, Claret, Francois X., primary, Ding, Zhiyong, primary, Chen, Jian, primary, Chen, Pingsheng, primary, Barton, Michelle C., primary, Peng, Guang, primary, Mills, Gordon B., primary, and Heimberger, Amy B., primary

Published
2023
Full Text
View/download PDF

88. Data from ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Author

Shen, Jianfeng, primary, Peng, Yang, primary, Wei, Leizhen, primary, Zhang, Wei, primary, Yang, Lin, primary, Lan, Li, primary, Kapoor, Prabodh, primary, Ju, Zhenlin, primary, Mo, Qianxing, primary, Shih, Ie-Ming, primary, Uray, Ivan P., primary, Wu, Xiangwei, primary, Brown, Powel H., primary, Shen, Xuetong, primary, Mills, Gordon B., primary, and Peng, Guang, primary

Published
2023
Full Text
View/download PDF

89. Supplementary Figure Legends from ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Author

Shen, Jianfeng, primary, Peng, Yang, primary, Wei, Leizhen, primary, Zhang, Wei, primary, Yang, Lin, primary, Lan, Li, primary, Kapoor, Prabodh, primary, Ju, Zhenlin, primary, Mo, Qianxing, primary, Shih, Ie-Ming, primary, Uray, Ivan P., primary, Wu, Xiangwei, primary, Brown, Powel H., primary, Shen, Xuetong, primary, Mills, Gordon B., primary, and Peng, Guang, primary

Published
2023
Full Text
View/download PDF

90. Supplementary Methods from ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Author

Shen, Jianfeng, primary, Peng, Yang, primary, Wei, Leizhen, primary, Zhang, Wei, primary, Yang, Lin, primary, Lan, Li, primary, Kapoor, Prabodh, primary, Ju, Zhenlin, primary, Mo, Qianxing, primary, Shih, Ie-Ming, primary, Uray, Ivan P., primary, Wu, Xiangwei, primary, Brown, Powel H., primary, Shen, Xuetong, primary, Mills, Gordon B., primary, and Peng, Guang, primary

Published
2023
Full Text
View/download PDF

91. Supplementary Figures 1 - 16 from ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

Author

Shen, Jianfeng, primary, Peng, Yang, primary, Wei, Leizhen, primary, Zhang, Wei, primary, Yang, Lin, primary, Lan, Li, primary, Kapoor, Prabodh, primary, Ju, Zhenlin, primary, Mo, Qianxing, primary, Shih, Ie-Ming, primary, Uray, Ivan P., primary, Wu, Xiangwei, primary, Brown, Powel H., primary, Shen, Xuetong, primary, Mills, Gordon B., primary, and Peng, Guang, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results