Search

Your search keyword '"Sgura, A."' showing total 1,848 results
Start Over Author "Sgura, A."
1,848 results on '"Sgura, A."'

52. The Control Unit of the KM3NeT Data Acquisition System

Author

Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Bendahman, M., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Biagioni, A., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipovic, M. D., Franco, A., Fusco, L. A., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Manczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. O', Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Puhlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The KM3NeT Collaboration runs a multi-site neutrino observatory in the Mediterranean Sea. Water Cherenkov particle detectors, deep in the sea and far off the coasts of France and Italy, are already taking data while incremental construction progresses. Data Acquisition Control software is operating off-shore detectors as well as testing and qualification stations for their components. The software, named Control Unit, is highly modular. It can undergo upgrades and reconfiguration with the acquisition running. Interplay with the central database of the Collaboration is obtained in a way that allows for data taking even if Internet links fail. In order to simplify the management of computing resources in the long term, and to cope with possible hardware failures of one or more computers, the KM3NeT Control Unit software features a custom dynamic resource provisioning and failover technology, which is especially important for ensuring continuity in case of rare transient events in multi-messenger astronomy. The software architecture relies on ubiquitous tools and broadly adopted technologies and has been successfully tested on several operating systems.

Published
2019
Full Text
View/download PDF

53. KM3NeT front-end and readout electronics system: hardware, firmware and software

Author

The KM3NeT Collaboration, Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Belias, A., Berbee, E., Berg, A. M. van den, Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Bissinger, M., Bos, P., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Brânzaş, H., Briel, M., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eeden, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipović, M. D., Fusco, L. A., Gajanana, D., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Santiago, E. Huesca, Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., K., Meghna K., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Timmer, P., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The KM3NeT research infrastructure being built at the bottom of the Mediterranean Sea will host water-Cherenkov telescopes for the detection of cosmic neutrinos. The neutrino telescopes will consist of large volume three-dimensional grids of optical modules to detect the Cherenkov light from charged particles produced by neutrino-induced interactions. Each optical module houses 31 3-inch photomultiplier tubes, instrumentation for calibration of the photomultiplier signal and positioning of the optical module and all associated electronics boards. By design, the total electrical power consumption of an optical module has been capped at seven watts. This paper presents an overview of the front-end and readout electronics system inside the optical module, which has been designed for a 1~ns synchronization between the clocks of all optical modules in the grid during a life time of at least 20 years., Comment: Prepared submission to Journal of Astronomical Telescopes, Instruments, and Systems (JATIS)

Published
2019

54. Dependence of atmospheric muon flux on seawater depth measured with the first KM3NeT detection units

Author

KM3NeT Collaboration, Ageron, M., Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Pree, S. Basegmez du, Belias, A., Berbee, E., Berg, A. M. van den, Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Bissinger, M., de Boer, R., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Briel, M., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calì, C., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Colonges, S., Coniglione, R., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., Dallier, R., De Palma, M., De Sio, C., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., van Dooren, L., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eeden, T., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipović, M. D., Fusco, L. A., Gajanana, D., Gal, T., Soto, A. Garcia, Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Grimaldi, A., Grmek, A., Guderian, D., Guerzoni, M., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Henry, S., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Santiago, E. Huesca, Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Kayzel, F., Keller, P., Chowdhury, N. R. Khan, van der Knaap, F., Koffeman, E. N., Kooijman, P., Koopstra, J., Kouchner, A., Kreter, M., Kulikovskiy, V., K., Meghna K., Lahmann, R., Lamare, P., Larosa, G., Laurence, J., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Librizzi, F., Lincetto, M., Litrico, P., Alvarez, C. D. Llorens, Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Mongelli, M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Panagopoulos, V., Pancaldi, G., Papalashvili, G., Papaleo, R., Pastore, C., Păvălaş, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Rigalleau, L., Rizza, G., Rocco, R., Rovelli, A., Royon, J., Salemi, M., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schmelling, J., Sciacca, V., Sciliberto, D., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tayalati, Y., Tenllado, E., Tézier, D., Thakore, T., Theraube, S., Timmer, P., Tingay, S., Trovato, A., Tsagkli, S., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

KM3NeT is a research infrastructure located in the Mediterranean Sea, that will consist of two deep-sea Cherenkov neutrino detectors. With one detector (ARCA), the KM3NeT Collaboration aims at identifying and studying TeV-PeV astrophysical neutrino sources. With the other detector (ORCA), the neutrino mass ordering will be determined by studying GeV-scale atmospheric neutrino oscillations. The first KM3NeT detection units were deployed at the Italian and French sites between 2015 and 2017. In this paper, a description of the detector is presented, together with a summary of the procedures used to calibrate the detector in-situ. Finally, the measurement of the atmospheric muon flux between 2232-3386 m seawater depth is obtained., Comment: 15 pages, 9 figures

Published
2019
Full Text
View/download PDF

55. Matrix-oriented discretization methods for reaction-diffusion PDEs: comparisons and applications

Author

D'Autilia, Maria Chiara, Sgura, Ivonne, and Simoncini, Valeria

Subjects
Mathematics - Numerical Analysis
Abstract

Systems of reaction-diffusion partial differential equations (RD-PDEs) are widely applied for modelling life science and physico-chemical phenomena. In particular, the coupling between diffusion and nonlinear kinetics can lead to the so-called Turing instability, giving rise to a variety of spatial patterns (like labyrinths, spots, stripes, etc.) attained as steady state solutions for large time intervals. To capture the morphological peculiarities of the pattern itself, a very fine space discretization may be required, limiting the use of standard (vector-based) ODE solvers in time because of excessive computational costs. We show that the structure of the diffusion matrix can be exploited so as to use matrix-based versions of time integrators, such as Implicit-Explicit (IMEX) and exponential schemes. This implementation entails the solution of a sequence of discrete matrix problems of significantly smaller dimensions than in the vector case, thus allowing for a much finer problem discretization. We illustrate our findings by numerically solving the Schnackenberg model, prototype of RD-PDE systems with Turing pattern solutions, and the DIB-morphochemical model describing metal growth during battery charging processes., Comment: 26 pages, 9 figures, 2 tables

Published
2019

56. First observation of the cosmic ray shadow of the Moon and the Sun with KM3NeT/ORCA

Author

S. Aiello, A. Albert, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, M. Anghinolfi, M. Anguita, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, L. Bailly-Salins, B. Baret, S. Basegmez du Pree, Y. Becherini, M. Bendahman, F. Benfenati, E. Berbee, V. Bertin, S. Biagi, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, F. Carenini, V. Carretero, P. Castaldi, S. Celli, L. Cerisy, M. Chabab, N. Chau, A. Chen, R. Cherkaoui El Moursli, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, Y. Darras, A. De Benedittis, B. De Martino, R. Del Burgo, I. Di Palma, A. F. Dìaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, E. Drakopoulou, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, M. Eff, D. van Eijk, I. El Bojaddaini, S. El Hedri, A. Enzenhöfer, V. Espinosa, G. Ferrara, M. D. Filipović, F. Filippini, L. A. Fusco, J. Gabriel, T. Gal, J. García Méndez, A. Garcia Soto, F. Garufi, C. Gatius Oliver, N. Geißelbrecht, L. Gialanella, E. Giorgio, A. Girardi, I. Goos, S. R. Gozzini, R. Gracia, K. Graf, D. Guderian, C. Guidi, B. Guillon, M. Gutiérrez, L. Haegel, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. James, D. Janezashvili, M. de Jong, P. de Jong, B. J. Jung, P. Kalaczyński, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, M. Labalme, R. Lahmann, A. Lakhal, M. Lamoureux, G. Larosa, C. Lastoria, A. Lazo, R. Le Breton, S. Le Stum, G. Lehaut, E. Leonora, N. Lessing, G. Levi, S. Liang, M. Lindsey Clark, F. Longhitano, L. Maderer, J. Majumdar, J. Mańczak, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, M. Mastrodicasa, S. Mastroianni, K. W. Melis, S. Miccichè, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, C. M. Mollo, L. Morales-Gallegos, C. Morley-Wong, A. Moussa, R. Muller, M. R. Musone, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó. Fearraigh, A. Orlando, E. Oukacha, J. Palacios González, G. Papalashvili, R. Papaleo, E. J. Pastor Gomez, A. M. Păun, G. E. Păvălaş, C. Pellegrino, S. Peña Martínez, M. Perrin-Terrin, J. Perronnel, V. Pestel, P. Piattelli, O. Pisanti, C. Poirè, V. Popa, T. Pradier, S. Pulvirenti, G. Quéméner, U. Rahaman, N. Randazzo, S. Razzaque, I. C. Rea, D. Real, S. Reck, G. Riccobene, J. Robinson, A. Romanov, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, C. Santonastaso, D. Santonocito, P. Sapienza, A. Sathe, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Simonelli, A. Sinopoulou, M. V. Smirnov, B. Spisso, M. Spurio, D. Stavropoulos, S. M. Stellacci, M. Taiuti, K. Tavzarashvili, Y. Tayalati, H. Tedjditi, H. Thiersen, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, H. Warnhofer, J. Wilms, E. de Wolf, H. Yepes-Ramirez, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract This article reports the first observation of the Moon and the Sun shadows in the sky distribution of cosmic-ray induced muons measured by the KM3NeT/ORCA detector. The analysed data-taking period spans from February 2020 to November 2021, when the detector had 6 Detection Units deployed at the bottom of the Mediterranean Sea, each composed of 18 Digital Optical Modules. The shadows induced by the Moon and the Sun were detected at their nominal position with a statistical significance of 4.2 $$\sigma $$ σ and 6.2 $$\sigma $$ σ , and an angular resolution of $$\sigma _{res}=0.49^\circ $$ σ res = 0 . 49 ∘ and $$\sigma _{res}=0.66^\circ $$ σ res = 0 . 66 ∘ , respectively, consistent with the prediction of $$0.53^\circ $$ 0 . 53 ∘ from simulations. This early result confirms the effectiveness of the detector calibration, in time, position and orientation and the accuracy of the event direction reconstruction. This also demonstrates the performance and the competitiveness of the detector in terms of pointing accuracy and angular resolution.

Published
2023
Full Text
View/download PDF

58. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study

Author

Pompei, Graziella, Campo, Gianluca, Ruggiero, Rossella, Maffeo, Diego, Sgura, Fabio, Arrotti, Salvatore, Preti, Gerlando, Iannaccone, Mario, Erriquez, Andrea, Biscaglia, Simone, Sganzerla, Paolo, Capecchi, Alessandro, Pignatelli, Gianluca, Dall'Ara, Gianni, Saia, Francesco, Tomassini, Francesco, Rolfo, Cristina, Varbella, Ferdinando, and Cerrato, Enrico

Published
2023
Full Text
View/download PDF

61. Overview of DISCOVER22 experiment in the framework of INFN-LNGS Cosmic Silence activity: challenges and improvements in underground radiobiology

Author

Patrizia Morciano, Valentina Dini, Francesco Berardinelli, Giorgio Baiocco, Valeria Conte, Ion Udroiu, Federica Barbato, Jessica Marinaccio, Pasqualino Anello, Antonio Antoccia, Maria Antonella Tabocchini, Anna Selva, Stefania Canella, Anna Bianchi, Isabella Guardamagna, Leonardo Lonati, Emanuele Scifoni, Matthias Laubenstein, Marco Balata, Francesco Ferella, Daniela Grifoni, Angelo Galante, Mauro Maccarrone, Valentina Tirelli, Felicia Grasso, Massimo Sanchez, and Antonella Sgura

Subjects
underground radiobiology, deep underground laboratories, environmental radiation, immune response, low radiation, microdosimetry, Physics, QC1-999
Abstract

One of the most intriguing and still pending questions in radiobiology is to understand whether and how natural environmental background radiation has shaped Life over millions of years of evolution on Earth. Deep Underground Laboratories (DULs) represent the ideal below-background exposure facilities where to address such a question. Among the few worldwide DULs, INFN-Laboratorio Nazionale del Gran Sasso (LNGS) is one of the largest in terms of size and infrastructure. Designed and built to host neutrino and dark matter experiments, since the 1990 s the LNGS has been one of the first DULs to systematically host radiobiology experiments. Here we present the DISCOVER22 (DNA Damage and Immune System Cooperation in VEry low Radiation environment 2022) experiment recently started at LNGS. DISCOVER22 aims at investigating how the low radiation background modulates the Immune System (IS) response in in vitro and in vivo models. Underground radiobiology experiments are particularly complex and tricky to design and perform. In these studies, the accurate characterization of exposure scenarios is mandatory, but a challenging aspect is to understand how the very few ionizing tracks in the ultra-Low Radiation Environment (LRE) interact with the living matter in space and time in order to trigger different biological responses. In this Perspective, we describe these challenges and how we address them through a microdosimetric and a radiobiological approaches. We aim at linking physical microdosimetric measurements and the corresponding biological radiation responses by using radiation biophysical models that could shed light on many as yet unresolved questions.

Published
2023
Full Text
View/download PDF

63. Sensitivity of the KM3NeT/ARCA neutrino telescope to point-like neutrino sources

Author

The KM3NeT Collaboration, Aiello, S., Akrame, S. E., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Avgitas, T., Bagatelas, C., Barbarino, G., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Biagi, S., Biagioni, A., Biernoth, C., Boumaaza, J., Bourret, S., Bouta, M., Bouwhuis, M., Bozza, C., Brânzas, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., De Sio, C., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., van Eijk, D., Bojaddaini, I. El, Eljarrari, H., Elsaesser, D., Enzenhöfer, A., Fermani, P., Ferrara, G., Filipovic, M. D., Fusco, L. A., Gal, T., Garcia, A., Garufi, F., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grégoire, T., Grella, G., Hallmann, S., Hamdaoui, H., van Haren, H., Heid, T., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Illuminati, G., James, C. W., Jongen, M., de Jong, M., de Jong, P., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kiessling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Kunhikannan-Kannichankandy, M., Lahmann, R., Larosa, G., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Coto, D. Lopez, Lotze, M., Maderer, L., Maggi, G., Manczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Fearraigh, B. Ó, Organokov, M., Orlando, A., Ottonello, S., Panagopoulos, V., Papalashvili, G., Papaleo, R., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Saffer, M., Salvadori, I., Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schumann, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Thakore, T., Trovato, A., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., de Wolf, E., Zaborov, D., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

KM3NeT will be a network of deep-sea neutrino telescopes in the Mediterranean Sea. The KM3NeT/ARCA detector, to be installed at the Capo Passero site (Italy), is optimised for the detection of high-energy neutrinos of cosmic origin. Thanks to its geographical location on the Northern hemisphere, KM3NeT/ARCA can observe upgoing neutrinos from most of the Galactic Plane, including the Galactic Centre. Given its effective area and excellent pointing resolution, KM3NeT/ARCA will measure or significantly constrain the neutrino flux from potential astrophysical neutrino sources. At the same time, it will test flux predictions based on gamma-ray measurements and the assumption that the gamma-ray flux is of hadronic origin. Assuming this scenario, discovery potentials and sensitivities for a selected list of Galactic sources and to generic point sources with an $E^{-2}$ spectrum are presented. These spectra are assumed to be time independent. The results indicate that an observation with $3\sigma$ significance is possible in about six years of operation for the most intense sources, such as Supernovae Remnants RX\,J1713.7-3946 and Vela Jr. If no signal will be found during this time, the fraction of the gamma-ray flux coming from hadronic processes can be constrained to be below 50\% for these two objects., Comment: 32 pages, 9 figures, submitted to Astroparticle Physics

Published
2018
Full Text
View/download PDF

64. Quantitative flow ratio-based outcomes in patients undergoing transcatheter aortic valve implantation quaestio study

Author

Pierluigi Demola, Iginio Colaiori, Davide Bosi, Sergio Musto D’Amore, Marco Vitolo, Giorgio Benatti, Luigi Vignali, Iacopo Tadonio, Davide Gabbieri, Luciano Losi, Paolo Magnavacchi, Fabio Alfredo Sgura, Giuseppe Boriani, and Vincenzo Guiducci

Subjects
aortic stenosis, coronary artery disease, coronary physiology, fractional flow reserve, quantitative flow ratio (QFR), Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundCoronary artery disease (CAD) is common in patients with aortic valve stenosis (AS) ranging from 60% to 80%. The clinical and prognostic role of coronary artery lesions in patients undergoing Transcatheter Aortic Valve Implantation (TAVI) remains unclear. The aim of the present observational study was to estimate long-term clinical outcomes by Quantitative Flow Ratio (QFR) characterization of CAD in a well-represented cohort of patients affected by severe AS treated by TAVI.MethodsA total of 439 invasive coronary angiographies of patients deemed eligible for TAVI by local Heart Teams with symptomatic severe AS were retrospectively screened for QFR analysis. The primary endpoint of the study was all-cause mortality. The secondary endpoint was a composite of cardiovascular mortality, stroke/transient ischemic attack (TIA), acute myocardial infarction (AMI), and any hospitalization after TAVI.ResultsAfter exclusion of patients with no follow-up data, coronary angiography not feasible for QFR analysis and previous surgical myocardial revascularization (CABG) 48/239 (20.1%) patients had a QFR value lower or equal to 0.80 (QFR + value), while the remaining 191/239 (79.9%) did not present any vessel with a QFR positive value. In the adjusted Cox regression analysis, patients with positive QFR were independently associated with an increased risk of all-casual mortality (Model 1, HR 3.47, 95% CI, 2.35−5.12; Model 2, HR 5.01, 95% CI, 3.17−7.90). In the adjusted covariate analysis, QFR+ involving LAD (37/48, 77,1%) was associated with the higher risk of the composite outcome compared to patients without any positive value of QFR or non-LAD QFR positive value (11/48, 22.9%).ConclusionsPre-TAVI QFR analysis can be used for a safe, simple, wireless functional assessment of CAD. QFR permits to identify patients at high risk of cardiovascular mortality or MACE, and it could be considered by local Heart Teams.

Published
2023
Full Text
View/download PDF

65. Probing invisible neutrino decay with KM3NeT/ORCA

Author

Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Bailly-Salins, L., Baret, B., Basegmez du Pree, S., Becherini, Y., Bendahman, M., Benfenati, F., Berbee, E., Bertin, V., Biagi, S., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carenini, F., Carretero, V., Castaldi, P., Celli, S., Cerisy, L., Chabab, M., Chau, N., Chen, A., Cherkaoui El Moursli, R., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., Darras, Y., De Benedittis, A., De Martino, B., Decoene, V., Del Burgo, R., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drakopoulou, E., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., Eff, M., van Eijk, D., El Bojaddaini, I., El Hedri, S., Enzenhöfer, A., Espinosa, V., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gabriel, J., Gal, T., García Méndez, J., Garcia Soto, A., Garufi, F., Gatius Oliver, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Girardi, A., Goos, I., Gozzini, S. R., Gracia, R., Graf, K., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haegel, L., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lakhal, A., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonora, E., Lessing, N., Levi, G., Liang, S., Lindsey Clark, M., Longhitano, F., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastrodicasa, M., Mastroianni, S., Melis, K. W., Miccichè, S., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Mollo, C. M., Morales-Gallegos, L., Morley-Wong, C., Moussa, A., Muller, R., Musone, M. R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, Orlando, A., Oukacha, E., Palacios González, J., Papalashvili, G., Papaleo, R., Pastor Gomez, E. J., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Peña Martínez, S., Perrin-Terrin, M., Perronnel, J., Pestel, V., Piattelli, P., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pulvirenti, S., Quéméner, G., Rahaman, U., Randazzo, N., Razzaque, S., Rea, I. C., Real, D., Reck, S., Riccobene, G., Robinson, J., Romanov, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonastaso, C., Santonocito, D., Sapienza, P., Sathe, A., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simonelli, A., Sinopoulou, A., Smirnov, M. V., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tavzarashvili, K., Tayalati, Y., Tedjditi, H., Thakore, T., Thiersen, H., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Van Elewyck, V., Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., Warnhofer, H., Wilms, J., de Wolf, E., Yepes-Ramirez, H., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Published
2023
Full Text
View/download PDF

67. Drosophila telomeric protein Verrocchio is an ortholog of STN1.

Author

Udroiu, Ion and Sgura, Antonella

Abstract

In most Eukaryota, telomeres are protected by the CST complex, composed of CTC1, STN1 and TEN1. In Drosophila, instead, another complex is present, composed of Modigliani, Tea and Verrocchio. We performed a search for STN1 orthologs in Arthropoda, in order to verify if Verrocchio can be considered as such. We found that STN1 in Arthropoda is shorter than in other Metazoa and shares the same architecture with Verrocchio. Despite high sequence divergence between human and Drosophila, we have discovered that Verrocchio is an ortholog of STN1. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

72. An integrated approach for chemical water quality assessment of an urban river stretch through Effect-Based Methods and emerging pollutants analysis with a focus on genotoxicity

Author

Carere, Mario, Antoccia, Antonio, Buschini, Annamaria, Frenzilli, Giada, Marcon, Francesca, Andreoli, Cristina, Gorbi, Gessica, Suppa, Antonio, Montalbano, Serena, Prota, Valentina, De Battistis, Francesca, Guidi, Patrizia, Bernardeschi, Margherita, Palumbo, Mara, Scarcelli, Vittoria, Colasanti, Marco, D'Ezio, Veronica, Persichini, Tiziana, Scalici, Massimiliano, Sgura, Antonella, Spani, Federica, Udroiu, Ion, Valenzuela, Martina, Lacchetti, Ines, di Domenico, Kevin, Cristiano, Walter, Marra, Valentina, Ingelido, Anna Maria, Iacovella, Nicola, De Felip, Elena, Massei, Riccardo, and Mancini, Laura

Published
2021
Full Text
View/download PDF

74. Statin-Induced Necrotizing Autoimmune Myopathy: Case Report of a Patient under Chronic Treatment

Author

Ilaria Anna Bellofatto, Marta Sessarego, Amedeo Tirandi, Chiara Olivero, Cosimo Sgura, Elia Maioli, Aurora Gavoci, Elisa Schiavetta, Federica Frè, Benedetta Saccomanno, Federico Zaottini, Riccardo Picasso, Chiara Fiorillo, Luca Liberale, Luciano Carlo Ottonello, Nicholas Bardi, and Fabrizio Montecucco

Subjects
Medicine
Abstract

Introduction. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors are widely used worldwide to treat dyslipidaemia and prevent cardiovascular events. Statins can cause a wide variety of muscle injuries ranging from myalgia to severe rhabdomyolysis. In most cases, these symptoms are mild and self-limiting and do not require specific treatment besides drug withdrawal. Statin-induced autoimmune necrotizing myopathy (SINAM) is a rare but potentially fatal complication, characterized by the subacute onset of progressive proximal muscle weakness and considerably high creatine phosphokinase (CK) levels in patients exposed to statins. The diagnosis is supported by the presence of antibodies HMGCR, which allows the differentiation from other forms of necrotizing autoimmune myopathies. Symptoms usually progress even after statin discontinuation and can determine severe muscle damage. Summary. We describe the case of a 77-year-old man who developed SINAM after 5 years of statin use. He suffered from muscle functional impairment mainly involving proximal lower limb muscles which progressed to the point that he almost became bedridden. Initial treatment with prednisone alone was not effective, and he required a combination therapy with steroids, methotrexate, and intravenous immunoglobulins. After 5 months of therapy and rehabilitation, he showed complete laboratory response and muscle strength recovery. Conclusion. Recognizing SINAM is paramount in order to promptly start treatment and avoid permanent muscle damage. Using a combination therapy from the beginning could contribute to a better outcome. Prompt statin cessation, categorization of the muscle disease by autoantibody testing, imaging, and histology, exclusion of malignancy, and anti-inflammatory therapy with corticosteroids, antimetabolites, immunoglobulins, and in some cases rituximab are currently accepted approaches to this entity.

Published
2023
Full Text
View/download PDF

75. Virtual Element Method for the Laplace-Beltrami equation on surfaces

Author

Frittelli, Massimo and Sgura, Ivonne

Subjects
Mathematics - Numerical Analysis, 65N15, 65N30
Abstract

We present and analyze a Virtual Element Method (VEM) of arbitrary polynomial order $k\in\mathbb{N}$ for the Laplace-Beltrami equation on a surface in $\mathbb{R}^3$. The method combines the Surface Finite Element Method (SFEM) [Dziuk, Elliott, \emph{Finite element methods for surface PDEs}, 2013] and the recent VEM [Beirao da Veiga et al, \emph{Basic principles of Virtual Element Methods}, 2013] in order to handle arbitrary polygonal and/or nonconforming meshes. We account for the error arising from the geometry approximation and extend to surfaces the error estimates for the interpolation and projection in the virtual element function space. In the case $k=1$ of linear Virtual Elements, we prove an optimal $H^1$ error estimate for the numerical method. The presented method has the capability of handling the typically nonconforming meshes that arise when two ore more meshes are pasted along a straight line. Numerical experiments are provided to confirm the convergence result and to show an application of mesh pasting., Comment: 25 pages, 6 figures

Published
2016
Full Text
View/download PDF

76. Intrinsic limits on resolutions in muon- and electron-neutrino charged-current events in the KM3NeT/ORCA detector

Author

Adrián-Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Palma, I., Díaz, A. F., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., Bojaddaini, I. El, Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Leisos, A., Leone, F., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Presti, D. Lo, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Marinelli, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Pleinert, M. -O., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rauch, T., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., García, A. Sánchez, Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zornoza, J. D., and Zúñiga, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Studying atmospheric neutrino oscillations in the few-GeV range with a multimegaton detector promises to determine the neutrino mass hierarchy. This is the main science goal pursued by the future KM3NeT/ORCA water Cherenkov detector in the Mediterranean Sea. In this paper, the processes that limit the obtainable resolution in both energy and direction in charged-current neutrino events in the ORCA detector are investigated. These processes include the composition of the hadronic fragmentation products, the subsequent particle propagation and the photon-sampling fraction of the detector. GEANT simulations of neutrino interactions in seawater produced by GENIE are used to study the effects in the 1 - 20 GeV range. It is found that fluctuations in the hadronic cascade in conjunction with the variation of the inelasticity y are most detrimental to the resolutions. The effect of limited photon sampling in the detector is of significantly less importance. These results will therefore also be applicable to similar detectors/media, such as those in ice., Comment: 37 pages, 28 figures, JHEP published version

Published
2016
Full Text
View/download PDF

77. Lumped finite element method for reaction-diffusion systems on compact surfaces

Author

Frittelli, Massimo, Madzvamuse, Anotida, Sgura, Ivonne, and Venkataraman, Chandrasekhar

Subjects
Mathematics - Numerical Analysis, 65N15, 65N30
Abstract

We propose and analyse a novel surface finite element method that preserves the invariant regions of systems of semilinear parabolic equations on closed compact surfaces in $\mathbb{R}^3$ under discretisation. We also provide a fully-discrete scheme by applying the implicit-explicit (IMEX) Euler method in time. We prove the preservation of the invariant rectangles of the continuous problem under spatial and full discretizations. For scalar equations, these results reduce to the well-known discrete maximum principle. Furthermore, we prove optimal error bounds for the semi- and fully-discrete methods, that is the convergence rates are quadratic in the meshsize and linear in the timestep. Numerical experiments are provided to support the theoretical findings. In particular we provide examples in which, in the absence of lumping, the numerical solution violates the invariant region leading to blow-up due to the nature of the kinetics., Comment: 34 pages, 5 figures, 4 tables

Published
2016
Full Text
View/download PDF

78. Methodical Fitting for Mathematical Models of Rubber-like Materials

Author

Destrade, Michel, Saccomandi, Giuseppe, and Sgura, Ivonne

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

A great variety of models can describe the non-linear response of rubber to uni-axial tension. Yet an in-depth understanding of the successive stages of large extension is still lacking. We show that the response can be broken down in three steps, which we delineate by relying on a simple formatting of the data, the so-called Mooney transform. First, the small-to-moderate regime, where the polymeric chains unfold easily and the Mooney plot is almost linear. Second, the strain-hardening regime, where blobs of bundled chains unfold to stiffen the response in correspondence to the "upturn" of the Mooney plot. Third, the limiting-chain regime, with a sharp stiffening occurring as the chains extend towards their limit. We provide strain-energy functions with terms accounting for each stage, that (i) give an accurate local and then global fitting of the data; (ii) are consistent with weak non-linear elasticity theory; and (iii) can be interpreted in the framework of statistical mechanics. We apply our method to Treloar's classical experimental data and also to some more recent data. Our method not only provides models that describe the experimental data with a very low quantitative relative error, but also shows that the theory of non-linear elasticity is much more robust that seemed at first sight.

Published
2016
Full Text
View/download PDF

80. Impact of Wheat Non-Starch Polysaccharides on the Intestinal Wall and Microflora in Broilers

Author

Lavinia Ștef, Gabi Dumitrescu, Dan Drinceanu, Ducu Ștef, Călin Julean, Nicolae Corcionivoschi, Cosmin Pandur, and Ioana Sgura

Subjects
broilers intestinal microflora, intestinal wall, non starch polysaccharides, Agriculture, Technology, Science
Abstract

Some cereals like barley, oat, and wheat contain significant quantities of non-starch polysaccharides (NSP). The main problems generated by NSPs are related to their viscous nature, to the physiological and morphological effects on the digestive tract and to their interaction with the intestinal flora. The objective of this experiment was to assess the impact exerted by wheat non-starch polysaccharides (NSP) on the intestinal flora and wall in broilers. The experiment was carried out during 6 weeks. We created two experimental groups: the experimental group EG1 fed on forage without wheat in its structure, and the experimental group EG2 fed on combined forage including 40% wheat. At 6 weeks old, after broiler killing, we sampled the intestinal wall and determined lactic bacteria and coliforms. Wheat incorporation in a proportion of 40 % in the combined forage determines the increase of NSP content with 1.84 percentage points; the number of lactic bacteria decreases insignificantly in EG2, fed on forage including wheat. In the experimental variant EG2, the mean height of the jejunal mucosa vilosity was bigger (684.6μ) than in the variant EG1 (403.9 μ), and these were coated with a slightly-hypertrophic epithelium (32.4 μ); on some of the areas, the capillaries were ectasied and we could notice hemorrhagic regions.

Published
2023

81. Sensitivity to light sterile neutrino mixing parameters with KM3NeT/ORCA

Author

The KM3NeT collaboration, S. Aiello, A. Albert, M. Alshamsi, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulakis, M. Anghinolfi, M. Anguita, G. Anton, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A. M. van den Berg, V. Bertin, S. Biagi, M. Bissinger, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, F. Bretaudeau, R. Bruijn, J. Brunner, R. Bruno, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, S. Campion, A. Capone, V. Carretero, P. Castaldi, S. Celli, M. Chabab, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, R. Coniglione, P. Coyle, A. Creusot, A. Cruz, G. Cuttone, R. Dallier, B. De Martino, M. De Palma, I. Di Palma, A. F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, D. Elsaesser, A. Enzenhöfer, V. Espinosa, P. Fermani, G. Ferrara, M. D. Filipović, F. Filippini, L. A. Fusco, T. Gal, J. García Méndez, A. Garcia Soto, F. Garufi, Y. Gatelet, N. Geißelbrecht, L. Gialanella, E. Giorgio, S. R. Gozzini, R. Gracia, K. Graf, G. Grella, D. Guderian, C. Guidi, M. Gutiérrez, J. Haefner, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, J. Hofestädt, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. James, M. de Jong, P. de Jong, B. J. Jung, M. Kadler, P. Kalaczyński, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, V. Kulikovskiy, R. Lahmann, M. Lamoureux, G. Lara, G. Larosa, C. Lastoria, R. Le Breton, S. Le Stum, O. Leonardi, F. Leone, E. Leonora, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, F. Longhitano, D. Lopez-Coto, A. Lygda, L. Maderer, J. Mańczak, K. Mannheim, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, K. W. Melis, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Moser, A. Moussa, R. Muller, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Nkosi, B. Ó Fearraigh, M. O’Sullivan, M. Organokov, A. Orlando, J. Palacios González, G. Papalashvili, R. Papaleo, C. Pastore, A. M. Păun, G. E. Păvălaş, C. Pellegrino, S. Peña Martínez, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, O. Pisanti, C. Poirè, V. Pontoriere, V. Popa, T. Pradier, I. Probst, G. Pühlhofer, S. Pulvirenti, N. Randazzo, S. Razzaque, D. Real, S. Reck, G. Riccobene, A. Romanov, A. Rovelli, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, A. Santangelo, D. Santonocito, P. Sapienza, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, S. M. Stellacci, M. Taiuti, F. Tatone, Y. Tayalati, T. Thakore, H. Thiersen, S. Tingay, S. Tsagkli, V. Tsourapis, E. Tzamariudaki, D. Tzanetatos, V. Van Elewyck, G. Vasileiadis, F. Versari, D. Vivolo, G. de Wasseige, J. Wilms, R. Wojaczyński, E. de Wolf, T. Yousfi, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka

Subjects
Neutrino Detectors and Telescopes (experiments), Oscillation, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract KM3NeT/ORCA is a next-generation neutrino telescope optimised for atmospheric neutrino oscillations studies. In this paper, the sensitivity of ORCA to the presence of a light sterile neutrino in a 3+1 model is presented. After three years of data taking, ORCA will be able to probe the active-sterile mixing angles θ 14, θ 24, θ 34 and the effective angle θ μe , over a broad range of mass squared difference ∆ m 41 2 $$ \Delta {m}_{41}^2 $$ ∼ [10 −5 , 10] eV2, allowing to test the eV-mass sterile neutrino hypothesis as the origin of short baseline anomalies, as well as probing the hypothesis of a very light sterile neutrino, not yet constrained by cosmology. ORCA will be able to explore a relevant fraction of the parameter space not yet reached by present measurements.

Published
2021
Full Text
View/download PDF

82. Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study

Author

Ponticelli, Francesco, Khokhar, Arif A., Leenders, Geert, Konigstein, Maayan, Zivelonghi, Carlo, Agostoni, Pierfrancesco, van Kuijk, Jan-Peter, Ajmi, Issameddine, Lindsay, Steven, Bunc, Matjaž, Tebaldi, Matteo, Cafaro, Alessandro, Cheng, Kevin, Ielasi, Alfonso, Patterson, Tiffany, Wolter, Jan Sebastian, Sgura, Fabio, De Marco, Federico, Ioanes, Dan, D'Amico, Gianpiero, Ciardetti, Marco, Berti, Sergio, Guarracini, Stefano, Di Mauro, Michele, Gallone, Guglielmo, Dekker, Mirthe, Silvis, Max J.M., Tarantini, Giuseppe, Redwood, Simon, Colombo, Antonio, Liebetrau, Christoph, de Silva, Ranil, Rapezzi, Claudio, Ferrari, Roberto, Campo, Gianluca, Schnupp, Steffen, Timmers, Leo, Verheye, Stefan, Stella, Pieter, Banai, Shmuel, and Giannini, Francesco

Published
2021
Full Text
View/download PDF

86. Letter of Intent for KM3NeT 2.0

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belhorma, B., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bond, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Moursli, R. Cherkaoui El, Cherubini, S., Chiarusi, T., Circella, M., Classen, L., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amico, A., De Bonis, G., De Rosa, G., De Sio, C., Di Capua, F., Di Palma, I., García, A. F. Díaz, Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., Bojaddaini, I. El, Khayati, N. El, Elsaesser, D., Enzenhöfer, A., Fassi, F., Favali, P., Fermani, P., Ferrara, G., Frascadore, G., Filippidis, C., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Presti, D. Lo, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Margiotta, A., Marinelli, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., García, A. Sánchez, Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Tézier, D., Theraube, S., Thompson, L., Timmer, P., Tönnis, C., Trasatti, L., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Voulgaris, G., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The main objectives of the KM3NeT Collaboration are i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: 1) The high-energy astrophysical neutrino signal reported by IceCube and 2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergetic opportunities for the earth and sea sciences community. Three suitable deep-sea sites are identified, namely off-shore Toulon (France), Capo Passero (Italy) and Pylos (Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a 3-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be configured to fully explore the IceCube signal with different methodology, improved resolution and complementary field of view, including the Galactic plane. One building block will be configured to precisely measure atmospheric neutrino oscillations., Comment: 119 pages, published version, revised Eq. 6, 7

Published
2016
Full Text
View/download PDF

87. The prototype detection unit of the KM3NeT detector

Author

KM3NeT Collaboration, Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Androulakis, G. C., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouché, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Château, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhöfer, A., Fermani, P., Fusco, L. A., Gajanana, D., Gal, T., Galatà, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., GraciaRuiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestädt, J., Hogenbirk, J., Hugon, C., Hößl, J., Imbesi, M., James, C. W., Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leismüller, K. P., Leisos, A., Lenis, D., Leonora, E., LindseyClark, M., Alvarez, C. D. Llorens, Löhner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Masullo, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Pühlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldaña, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tézier, D., Théraube, S., Thompson, L. F., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the 40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 hours of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3{\deg}., Comment: Accepted for publication by EPJ C

Published
2015
Full Text
View/download PDF

88. Long term monitoring of the optical background in the Capo Passero deep-sea site with the NEMO tower prototype

Author

Adrián-Martínez, S., Aiello, S., Ameli, F., Anghinolfi, M., Ardid, M., Barbarino, G., Barbarito, E., Barbato, F. C. T., Beverini, N., Biagi, S., Biagioni, A., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Calí, C., Calvo, D., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Luca, V., Deniskina, N., De Rosa, G., di Capua, F., Distefano, C., Enzenhöfer, A., Fermani, P., Ferrara, G., Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovskiy, V., Lahmann, R., Larosa, G., Lattuada, D., Leismüller, K. P., Leonora, E., Litrico, P., Alvarez, C. D. Llorens, Lonardo, A., Longhitano, F., Presti, D. Lo, Maccioni, E., Margiotta, A., Marinelli, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Orzelli, A., Papaleo, R., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Randazzo, N., Real, D., Riccobene, G., Rovelli, A., Saldaña, M., Sanguineti, M., Sapienza, P., Sciacca, V., Sgura, I., Simeone, F., Sipala, V., Speziale, F., Spitaleri, A., Spurio, M., Stellacci, S. M., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., and Vivolo, D.

Subjects
Physics - Instrumentation and Detectors
Abstract

The NEMO Phase-2 tower is the first detector which was operated underwater for more than one year at the "record" depth of 3500 m. It was designed and built within the framework of the NEMO (NEutrino Mediterranean Observatory) project. The 380 m high tower was successfully installed in March 2013 80 km offshore Capo Passero (Italy). This is the first prototype operated on the site where the italian node of the KM3NeT neutrino telescope will be built. The installation and operation of the NEMO Phase-2 tower has proven the functionality of the infrastructure and the operability at 3500 m depth. A more than one year long monitoring of the deep water characteristics of the site has been also provided. In this paper the infrastructure and the tower structure and instrumentation are described. The results of long term optical background measurements are presented. The rates show stable and low baseline values, compatible with the contribution of 40K light emission, with a small percentage of light bursts due to bioluminescence. All these features confirm the stability and good optical properties of the site., Comment: 12 pages, 17 figures

Published
2015
Full Text
View/download PDF

89. Usefulness of Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina Pectoris

Author

D'Amico, Gianpiero, Giannini, Francesco, Massussi, Mauro, Tebaldi, Matteo, Cafaro, Alessandro, Ielasi, Alfonso, Sgura, Fabio, De Marco, Federico, Stefanini, Giulio G, Ciardetti, Marco, Versaci, Francesco, Latini, Roberto A, Saccà, Salvatore, Ghiringhelli, Sergio, Picchi, Andrea, Cerrito, Marco, Gaspardone, Achille, and Tarantini, Giuseppe

Published
2021
Full Text
View/download PDF

94. The Power Board of the KM3NeT Digital Optical Module: Design, Upgrade, and Production

Author

Aiello, Sebastiano, primary, Albert, Arnauld, additional, Garre, Sergio, additional, Aly, Zineb, additional, Ambrosone, Antonio, additional, Ameli, Fabrizio, additional, Andre, Michel, additional, Androutsou, Eleni, additional, Anguita, Mancia, additional, Aphecetche, Laurent, additional, Ardid, Miguel, additional, Ardid, Salva, additional, Atmani, Hicham, additional, Aublin, Julien, additional, Badaracco, Francesca, additional, Bailly-Salins, Louis, additional, Bardacova, Zuzana, additional, Baret, Bruny, additional, Bariego, Adriana, additional, Du Pree, Suzan, additional, Becherini, Yvonne, additional, Bendahman, Meriem, additional, Benfenati, Francesco, additional, Benhassi, Marouane, additional, Benoit, David, additional, Berbee, Edward, additional, Bertin, Vincent, additional, Biagi, Simone, additional, Boettcher, Markus, additional, Bonanno, Danilo, additional, Boumaaza, Jihad, additional, Bouta, Mohammed, additional, Bouwhuis, Mieke, additional, Bozza, Cristiano, additional, Bozza, Riccardo, additional, Branzas, Horea, additional, Bretaudeau, Felix, additional, Bruijn, Ronald, additional, Brunner, Jurgen, additional, Bruno, Riccardo, additional, Buis, Ernst, additional, Buompane, Raffaele, additional, Busto, Jose, additional, Caiffi, Barbara, additional, Calvo, David, additional, Campion, Stefano, additional, Capone, Antonio, additional, Carenini, Francesco, additional, Carretero, Víctor, additional, Cartraud, Théophile, additional, Castaldi, Paolo, additional, Cecchini, Vincent, additional, Celli, Silvia, additional, Cerisy, Luc, additional, Chabab, Mohamed, additional, Chadolias, Michael, additional, Champion, Cèdric, additional, Chen, Andrew, additional, Cherubini, Silvio, additional, Chiarusi, Tommaso, additional, Circella, Marco, additional, Cocimano, Rosanna, additional, Coelho, João, additional, Coleiro, Alexis, additional, Colonges, Stephane, additional, Coniglione, Rosa, additional, Coyle, Paschal, additional, Creusot, Alexandre, additional, Cuttone, Giacomo, additional, Dallier, Richard, additional, Darras, Yara, additional, De Benedittis, Antonio, additional, de Jong, Maarten, additional, de Jong, Paul, additional, De Martino, Bianca, additional, de Wolf, Els, additional, Decoene, Valentin, additional, Del Burgo, Riccardo, additional, Del Rosso, Ilaria, additional, Di Cerbo, Umberto, additional, Di Mauro, Letizia, additional, Di Palma, Irene, additional, Diaz, Antonio, additional, Martín, Cristian, additional, Diego-Tortosa, Dídac, additional, Distefano, Carla, additional, Domi, Alba, additional, Donzaud, Corinne, additional, Dornic, Damien, additional, Dörr, Manuel, additional, Drakopoulou, Evangelia, additional, Drouhin, Doriane, additional, Dvornický, Rastislav, additional, Eberl, Thomas, additional, Eckerova, Eliska, additional, Eddymaoui, Ahmed, additional, Eff, Maximilian, additional, El Bojaddaini, Imad, additional, El Hedri, Sonia, additional, Enzenhöfer, Alexander, additional, Ferrara, Giovanna, additional, Filipovic, Miroslav, additional, Filippini, Francesco, additional, Franciotti, Dino, additional, Antonio Fusco, Luigi, additional, Gabella, Omar, additional, Gabriel, Jean-Louis, additional, Gagliardini, Silvia, additional, Gal, Tamas, additional, García Méndez, Juan, additional, Garcia Soto, Alfonso, additional, Oliver, Clara, additional, Geißelbrecht, Nicole, additional, Ghaddari, Houria, additional, Gialanella, Lucio, additional, Gibson, Brad, additional, Giorgio, Emidio, additional, Goos, Isabel, additional, Goswami, Pranjupriya, additional, Goupilliere, Damien, additional, Gozzini, Sara, additional, Gracia, Rodrigo, additional, Graf, Kay, additional, Guidi, Carlo, additional, Guillon, Benoît, additional, Gutiérrez, Miguel, additional, Heijboer, Aart, additional, Hekalo, Amar, additional, Hennig, Lukas, additional, Hernandez-Rey, Juan-Jose, additional, Ibnsalih, Walid, additional, Illuminati, Giulia, additional, Jansweijer, Peter, additional, Jung, Bouke, additional, Kalaczyński, Piotr, additional, Kalekin, Oleg, additional, Katz, Uli, additional, Khatun, Amina, additional, Kistauri, Giorgi, additional, Kopper, Claudio, additional, Kouchner, Antoine, additional, Kueviakoe, Vincent, additional, Kulikovskiy, Vladimir, additional, Kvatadze, Ramaz, additional, Labalme, Marc, additional, Lahmann, Robert, additional, Larosa, Giuseppina, additional, Lastoria, Chiara, additional, Lazo, Alfonso, additional, Le Stum, Sebastien, additional, Lehaut, Grégory, additional, Leonora, Emanuele, additional, Lessing, Nadja, additional, Levi, Giuseppe, additional, Clark, Miles, additional, Litrico, Pietro, additional, Longhitano, Fabio, additional, Mańczak, Jerzy, additional, Majumdar, Jhilik, additional, Malerba, Leonardo, additional, Mamedov, Fadahat, additional, Manfreda, Alberto, additional, Marconi, Martina, additional, Margiotta, Annarita, additional, Marinelli, Antonio, additional, Markou, Christos, additional, Martin, Lilian, additional, Martínez-Mora, Juan, additional, Marzaioli, Fabio, additional, Mastrodicasa, Massimo, additional, Mastroianni, Stefano, additional, Miccichè, Sandra, additional, Miele, Gennaro, additional, Migliozzi, Pasquale, additional, Migneco, Emilio, additional, Minutoli, Saverio, additional, Mitsou, Maria, additional, Mollo, Carlos, additional, Gallegos, Lizeth, additional, Morga, Michele, additional, Moussa, Abdelilah, additional, Mateo, Ivan, additional, Muller, Rasa, additional, Musico, Paolo, additional, Musone, Maria, additional, Musumeci, Mario, additional, Navas, Sergio, additional, Nayerhoda, Amid, additional, Nicolau, Carlo, additional, Nkosi, Bhuti, additional, Fearraigh, Brían, additional, Oliviero, Veronica, additional, Orlando, Angelo, additional, Oukacha, Enzo, additional, Paesani, Daniele, additional, González, Juan, additional, Papalashvili, Gogita, additional, Parisi, Vittorio, additional, Pastor, Emilio, additional, Paun, Alice, additional, Pavalas, Gabriela, additional, Pellegrini, Giuliano, additional, Martinez, Santiago, additional, Perrin-Terrin, Mathieu, additional, Perronnel, Jerome, additional, Pestel, Valentin, additional, Pestes, Rebekah, additional, Piattelli, Paolo, additional, Poirè, Chiara, additional, Popa, Vlad, additional, Pradier, Thierry, additional, Prado, Jorge, additional, Pulvirenti, Sara, additional, Quemener, Gilles, additional, Quiroz, Carlos, additional, Rahaman, Ushak, additional, Randazzo, Nunzio, additional, Randriatoamanana, Richard, additional, Razzaque, Soebur, additional, Rea, Immacolata, additional, Real, Diego, additional, Riccobene, Giorgio, additional, Robinson, Joshua, additional, Romanov, Andrey, additional, Saina, Adrian, additional, Greus, Francisco, additional, Samtleben, Dorothea, additional, Losa, Agustín, additional, Sanfilippo, Simone, additional, Sanguineti, Matteo, additional, Santonastaso, Claudio, additional, Santonocito, Domenico, additional, Sapienza, Piera, additional, Schmelling, Jan-Willem, additional, Schnabel, Jutta, additional, Schumann, Johannes, additional, Schutte, Hester, additional, Seneca, Jordan, additional, Sennan, Nour-Eddine, additional, Setter, Bastian, additional, Sgura, Irene, additional, Shanidze, Rezo, additional, Sharma, Ankur, additional, Shitov, Yury, additional, Šimkovic, Fedor, additional, Simonelli, Andreino, additional, Sinopoulou, Anna, additional, Smirnov, Mikhail, additional, Spisso, Bernardino, additional, Spurio, Maurizio, additional, Stavropoulos, Dimitris, additional, Štekl, Ivan, additional, Taiuti, Mauro, additional, Tayalati, Yahya, additional, Thiersen, Hannes, additional, Melo, Iara, additional, Tragia, Efi, additional, Trocme, Benjamin, additional, Tsourapis, Vasileios, additional, Tzamariudaki, Ekaterini, additional, Vacheret, Antonin, additional, Melchor, Angel, additional, Valsecchi, Veronica, additional, van Beveren, Vincent, additional, van Eeden, Thijs, additional, van Eijk, Daan, additional, Van Elewyck, Véronique, additional, van Haren, Hans, additional, Vannoye, Godefroy, additional, Vasileiadis, George, additional, De Sola, Francisco, additional, Verilhac, Cedric, additional, Veutro, Alessandro, additional, Viola, Salvatore, additional, Vivolo, Daniele, additional, Wilms, Joern, additional, Ramirez, Harold, additional, Zarpapis, Giorgos, additional, Zavatarelli, Sandra, additional, Zegarelli, Angela, additional, Zito, Daniele, additional, de Dios Zornoza, Juan, additional, Zuñiga, Juan, additional, and Zywucka, Natalia, additional

Published
2024
Full Text
View/download PDF

98. Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower

Author

Aiello, S., Ameli, F., Anghinolfi, M., Barbarino, G., Barbarito, E., Barbato, F., Beverini, N., Biagi, S., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Calì, C., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Luca, V., Deniskina, N., De Rosa, G., Di Capua, F., Distefano, C., Fermani, P., Fusco, L. A., Garufi, F., Giordano, V., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovskiy, V., Larosa, G., Lattuada, D., Leismueller, K. P., Leonora, E., Litrico, P., Lonardo, A., Longhitano, F., Presti, D. Lo, Maccioni, E., Margiotta, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Papaleo, R., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Orselli, A., Raffaelli, F., Randazzo, N., Riccobene, G., Rovelli, A., Sanguineti, M., Sapienza, P., Sciacca, V., Sgura, I., Simeone, F., Sipala, V., Speziale, F., Spina, M., Spitaleri, A., Spurio, M., Stellacci, S. M., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., and Vivolo, D.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The results of the analysis of the data collected with the NEMO Phase-2 tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are presented. Cherenkov photons detected with the photomultipliers tubes were used to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution was measured and the results compared with Monte Carlo simulations. An evaluation of the systematic effects due to uncertainties on environmental and detector parameters is also included. The associated depth intensity relation was evaluated and compared with previous measurements and theoretical predictions. With the present analysis, the muon depth intensity relation has been measured up to 13 km of water equivalent., Comment: submitted to Astroparticle Physics

Published
2014
Full Text
View/download PDF

99. Deep sea tests of a prototype of the KM3NeT digital optical module

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou7, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galata, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Ruiz, R. Gracia, Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hosl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leisos, A., Lenis, D., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Lohner, H., Presti, D. Lo, Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

The first prototype of a photo-detection unit of the future KM3NeT neutrino telescope has been deployed in the deep waters of the Mediterranean Sea. This digital optical module has a novel design with a very large photocathode area segmented by the use of 31 three inch photomultiplier tubes. It has been integrated in the ANTARES detector for in-situ testing and validation. This paper reports on the first months of data taking and rate measurements. The analysis results highlight the capabilities of the new module design in terms of background suppression and signal recognition. The directionality of the optical module enables the recognition of multiple Cherenkov photons from the same $^{40}$K decay and the localization bioluminescent activity in the neighbourhood. The single unit can cleanly identify atmospheric muons and provide sensitivity to the muon arrival directions.

Published
2014
Full Text
View/download PDF

100. DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation

Author

Ion Udroiu, Antonella Sgura, Agnese Chendi, Lorenzo Lasagni, Marco Bertolini, Federica Fioroni, Vando Piccagli, Antonio Moramarco, Maria Grazia Romano, Luigi Fontana, Daniela D’Alessio, Vicente Bruzzaniti, Antonella Rosi, Sveva Grande, Alessandra Palma, Claudia Giliberti, Mauro Iori, Lorenzo Piergallini, Marco Sumini, Lorenzo Isolan, Giorgio Cucchi, Gaetano Compagnone, and Lidia Strigari

Subjects
Medicine, Science
Abstract

Abstract The current framework of radiological protection of occupational exposed medical workers reduced the eye-lens equivalent dose limit from 150 to 20 mSv per year requiring an accurate dosimetric evaluation and an increase understanding of radiation induced effects on Lens cells considering the typical scenario of occupational exposed medical operators. Indeed, it is widely accepted that genomic damage of Lens epithelial cells (LEC) is a key mechanism of cataractogenesis. However, the relationship between apoptosis and cataractogenesis is still controversial. In this study biological and physical data are combined to improve the understanding of radiation induced effects on LEC. To characterize the occupational exposure of medical workers during angiographic procedures an INNOVA 4100 (General Electric Healthcare) equipment was used (scenario A). Additional experiments were conducted using a research tube (scenario B). For both scenarios, the frequencies of binucleated cells, micronuclei, p21-positive cells were assessed with different doses and dose rates. A Monte-Carlo study was conducted using a model for the photon generation with the X-ray tubes and with the Petri dishes considering the two different scenarios (A and B) to reproduce the experimental conditions and validate the irradiation setups to the cells. The simulation results have been tallied using the Monte Carlo code MCNP6. The spectral characteristics of the different X-ray beams have been estimated. All irradiated samples showed frequencies of micronuclei and p21-positive cells higher than the unirradiated controls. Differences in frequencies increased with the delivered dose measured with Gafchromic films XR-RV3. The spectrum incident on eye lens and Petri, as estimated with MCNP6, was in good agreement in the scenario A (confirming the experimental setup), while the mean energy spectrum was higher in the scenario B. Nevertheless, the response of LEC seemed mainly related to the measured absorbed dose. No effects on viability were detected. Our results support the hypothesis that apoptosis is not responsible for cataract induced by low doses of X-ray (i.e. 25 mGy) while the induction of transient p21 may interfere with the disassembly of the nuclear envelop in differentiating LEC, leading to cataract formation. Further studies are needed to better clarify the relationship we suggested between DNA damage, transient p21 induction and the inability of LEC enucleation.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results