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This paper aims at understanding and evaluating the environmental and economic impacts of a crowdshipping platform in urban areas. The investigation refers to the city of Rome and considers an environmental-friendly crowdshipping based on the use of the mass transit network of the city, where customers/crowdshippers pick-up/drop-off goods in automated parcel lockers located either inside the transit stations or in their surroundings. Crowdshippers are passengers that would use the transit network anyhow for other activities (e.g., home-to-work), thus avoiding additional trips. The study requires firstly, estimating the willingness to buy a crowdshipping service like the one proposed here, in order to quantify the potential demand. The estimation is realized adopting an extensive stated preference survey and discrete choice modeling. Then, several scenarios with different features of the service are proposed and evaluated up to 2025 in terms of both externalities (local and global pollutant emissions, noise emissions and accidents reductions) and revenues. The results are useful to understand and quantify the potential of this strategy for last mile B2C deliveries. Moreover, it provides local policy-makers and freight companies with a good knowledge base for the future development of a platform for public transport-based crowdshipping and for estimating the likely impact the system could have both from an economic and environmental point of view. Keywords: crowdshipping; on demand; e-commerce; urban freight; discrete choice model; transport externalities; COPERT 1. Introduction

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of ROS, intracellular Ca(2+) overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes. Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase-associated lipocalin (NGAL) could be used as markers of I-R injury severity stages. This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease.