76 results on '"Sendag S"'
Search Results
52. Vulvahypoplasia in an alpaca cria – first case report in Germany
- Author
-
Schünemann, M., Böhm, J., Sendag, S., and Wehrend, A.
- Abstract
This is the first German case report of an alpaca cria suffering from a congenital vulvahypoplasia. Symptoms, diagnostics and therapy are described. The 24-hours-old cria was referred to the hospital due to reduced general condition and colic. The existent vulvahypoplasia led to impaired urination, causing further complications such as urovagina and urinary stasis up to the renal pelvis. Surgical construction of the rima vulvae cured the cria. As indicated by several cases published on the clinical picture of vulvahypoplasia during recent years, this congenital deformation could become an increasing problem in the alpaca population.
- Published
- 2012
53. Laboratory diagnostics in the urine of young and pregnant ewes
- Author
-
Sendag, S., Cetin, Y., Failing, K., and Wehrend, A.
- Published
- 2011
- Full Text
- View/download PDF
54. Sonographische Verlaufsuntersuchungen an trächtigen Hündinnen – ein Beitrag zur Bedeutung der Fruchtresorption beim Hund
- Author
-
Sendag, S., Dinc, D. A., Celik, H. A., Aydin, I., and Wehrend, A.
- Published
- 2010
- Full Text
- View/download PDF
55. Follow-up ultrasonographic examinations in pregnant bitches – evaluation of frequency and significance of embryo resorption
- Author
-
Sendag, S., Dinc, D. A., Celik, H. A., Aydin, I., and Wehrend, A.
- Abstract
Objective: Follow-up ultrasonographic examinations in pregnant bitches to evaluate frequency and significance of embryo resorption. Material and methods: In 39 Kangal bitches the number of gestational sacs was measured and vitality of embryos/fetuses was evaluated by real time ultrasonography daily from the 15th till the last day of gestation. Results: Five bitches (12.8%) showed embryonic resorption and one of these bitches exhibited a complete resorption. Fetal death could be observed in four females and was related to a total loss of the litter. After the first evidence of embryonic death gestational sacs remained detectable for 8.6±0.5days. The number of embryos of bitches with (10.8±1.8) or without embryo resorption (8.2±2.1) was statistically significantly different (p<0.05). On the other hand there was no statistically significant difference within the number of embryos of bitches suffering fetal death and bitches without embryo resorption (8.2±2.1) (p>0.05). A relationship between litter size and gestational length could not be verified (r=0.15; p>0.05). Conclusion and clinical relevance: Due to these results the hypothesis is postulated that embryonic resorption is a kind of protective mechanism of the maternal organism against too large litter sizes.
- Published
- 2010
56. Untersuchungen zur Bestimmung des Harn-pH-Werts bei Milchkühen
- Author
-
Sendag, S., Hollenhorst, M., and Wehrend, A.
- Published
- 2005
- Full Text
- View/download PDF
57. Long term suppression of oestrus and prevention of pregnancy by deslorelin implant in rats
- Author
-
Alkis, I., Yunus Cetin, Sendag, S., and Wehrend, A.
- Abstract
The experiments were designed to test the possibility to induce a down-regulation of pituitary GnRH-receptors and hence a suppression of oestrus by application of a long term deslorelin implant in female rats. Sixteen non pregnant female rats were randomly divided into two equal groups. The eight rats of the implant group (DESL) were subcutaneously implanted with long acting deslorelin implant, an analog of GnRH, at the dose of 4.7 mg, to inhibit oestrus. No treatment was applied to control group (CON). One adult male rat was added per cage of DESL and CON females after six weeks. Conceptions were diagnosed by inspection, palpation, and ultrasonography for one year. Conception rates were 0% and 100% in DESL group and CON group, respectively (P
58. Induction of oestrus with norgestomet in acyclic post-pubertal Holstein heifers
- Author
-
Yunus Cetin, Uslu, B. A., Gungor, O., and Sendag, S.
- Subjects
animal structures ,animal diseases - Abstract
The study was carried out during April and May 2006, on thirty-eight 15 - 23-month-old Holstein heifers with inactive ovaries, which were selected from a private dairy herd with 300 heifers. The heifers were randomly distributed into two groups: norgestomet group (n=29), and a control group (n=9). In the norgestomet group, silicone ear implants containing 6 mg of norgestomet were implanted, and a solution containing 3 mg of norgestomet and 5 mg of oestradiol valerate was injected intramuscularly. The silicone implants were removed 11 d later, and the heifers were continuously observed for signs of oestrus for three days. The heifers were inseminated 48 and 78 h after the removal of the implants, and after the first insemination they were treated with 50 tg of GnRH analogue. The rate of the induced oestrus was 86.2% (25/29) and 0% (0/9) in norgestomet and control groups, respectively. The pregnancy rate was 48.2% (14/29) and 0% (0/9) in norgestomet and control groups, respectively. Our results showed that fertile oestrus can be stimulated successfully in post-pubertal heifers with inactive ovaries by a norgestomet treatment, and successful pregnancy rate can be obtained by a fixed-time insemination during this oestrus.
59. Is there a relationship between serum minerals (Ca, Mg) and trace elements (Cu, Fe, Mn, Zn) at mating on pregnancy rates in fat-tailed Morkaraman sheep?
- Author
-
Bahat Comba, Sait Sendag, Barış Atalay Uslu, Ömer Uçar, Leyla Mis, Axel Wehrend, Volkan Koşal, Arzu Comba, İbrahim Taşal, Fetih Gülyüz, and Uslu, B.A., Division of Reproduction and Artificial Insemination, Faculty of Veterinary Sciences, University of Cumhuriyet, Sivas, Turkey, Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey -- Mis, L., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey -- Gulyuz, F., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Department of Animal Sciences, Faculty of Agriculture, University of Akdeniz, Antalya, Turkey -- Comba, B., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey -- Ucar, O., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Division of Reproduction and Artificial Insemination, Faculty of Veterinary Sciences, University of Atatürk, Erzurum, Turkey -- Tasal, I., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Division of Obstetrics and Gynaecology, Faculty of Veterinary Sciences, University of Mehmet Akif Ersoy, Burdur, Turkey -- Comba, A., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Research and Training Hospital, University of Yuzuncu Yil, Van, Turkey -- Kosal, V., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Division of Reproduction and Artificial Insemination, Faculty of Veterinary Sciences, University of Yuzuncu Yil, Van, Turkey -- Sendag, S., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Division of Obstetrics and Gynaecology, Faculty of Veterinary Sciences, University of Yuzuncu Yil, Van, Turkey -- Wehrend, A., Division of Physiology, Faculty of Veterinary Science, University of Yuzuncu Yil, Van, Turkey, Clinic for Obstetrics, Gynaecology and Andrology of Large and Small Animals with Veterinary Ambulance, Justus-Liebig-University, Giessen, D-35392, Germany
- Subjects
medicine.medical_specialty ,040301 veterinary sciences ,media_common.quotation_subject ,Biology ,Ewe ,0403 veterinary science ,Melatonin ,Animal science ,Pregnancy ,Synchronisation ,Internal medicine ,medicine ,Mating ,media_common ,Estrous cycle ,General Veterinary ,business.industry ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,medicine.disease ,Elements ,040201 dairy & animal science ,Anoestrus ,Endocrinology ,Serum minerals ,Reference values ,Animal Science and Zoology ,Reproduction ,Ultrasonography ,business ,Hormone ,medicine.drug - Abstract
The specific roles of nutrients in reproduction are not well defined in sheep. Hence, the relationships between certain mineral (Ca, Mg) and element (Cu, Fe, Mn, Zn) levels at mating and pregnancy rates was investigated in fat-tailed Morkaraman ewes synchronised with different hormones (melatonin, norgestomet implant and eCG) early in anoestrus season. For this purpose, 40 healthy ewes (aged 2-4 years) allocated in the synchronised (n=30) and no-treated group (n=10) were used during mid-May (suckling period). On the eCG injection day, fertile rams (n=8) were introduced into the groups and, then the oestrus signs were visually monitored twice daily for 7 days. The oestrous ewes were allowed to handmate using rotational (four rams daily) mating system. Additionally, jugular blood samples were collected on the days of onset of oestrus (before mating) for determination of serum Ca, Cu, Fe, Mg, Mn and Zn levels. Presence of pregnancies was diagnosed by real-time ultrasonography 35 days post-mating. Totally, 25 ewes became pregnant (21 ewes with stimulatedand 4 with spontaneous oestrus), while 9 ewes (all received stimulation) were not pregnant. In non-pregnant ewes, unlike other minerals and elements, the Cu and Zn values were significantly lower than their reference values (for Cu: 0.87±0.16 mg/dl vs. 9.20 mg/dl; for Zn: 2.06±0.30 ?g/dl vs. 3.8 ?g/dl, resp.; P0.05). Hence, the present findings indicate that the low Cu and Zn levels during the oestrus might adversely affect the subsequent pregnancy rate in suckling ewes. © 2017, Agricultural Research Communication Centre. All rights reserved.
- Published
- 2017
60. Oestrogen and progesterone concentrations in intrapartum cows with insufficient cervix dilation.
- Author
-
Sendag S, Koca D, Arslan T, Schuler G, and Wehrend A
- Subjects
- Animals, Female, Cattle, Pregnancy, Dystocia veterinary, Estradiol blood, Cattle Diseases blood, Progesterone blood, Cervix Uteri, Estrogens blood
- Abstract
The cervix is an important organ that has to dilate sufficiently at delivery to allow the foetus to transition to extrauterine life. Insufficient dilatation of the cervix (IDC) is a frequent cause of dystocia in cattle. The mechanisms underlying cervical opening and the pathogenesis of IDC are still widely unclear. Systematic studies on the relationship between IDC and steroid hormones have been limited and have yielded inconsistent findings. This study aimed to measure oestrogen and progesterone (P4) concentrations in intrapartum cows presented with dystocia due to IDC and in a comparison (C) group of cows with eutocic delivery. Before any obstetrical procedures, and right after the initial evaluation, blood samples were taken from IDC and C animals. Concentrations of P4, oestradiol-17β (E2), free total oestrogens (FTE) and conjugated total oestrogens (CTE) were measured by established radioimmunoassays. Concentrations of P4 (p = .538), FTE (p = .065) and CTE (p = .605) were not statistically different between C and IDC groups. However, E2 levels in group C were significantly lower when compared to those in the IDC group (p = .013), which is inconsistent with the function of oestrogens in cervical dilatation. The correlation analysis demonstrated significant positive correlations between the pairs P4 versus FTE, P4 versus E2 and FTE versus E2 in group C and between the pair FTE versus E2 in group IDC. In conclusion, the results suggest that local activities of steroids relevant to the aetiology of IDC are not reflected by concentrations in the systemic circulation or that other factors are clearly more important., (© 2024 The Author(s). Reproduction in Domestic Animals published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
61. Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios?
- Author
-
Bayram E, Kidi MM, Camadan YA, Biter S, Yaslikaya S, Toyran T, Mete B, Kara IO, and Sahin B
- Abstract
Background : The purposes of neoadjuvant chemotherapy are to tumor size to improve the tumor removal rate, extend survival, and prevent metastasis. In this study, the importance of CRP/albumin ratio and CEA/albumin ratio in the prediction of neoadjuvant treatment response in gastric cancer patients was evaluated. Methods : This study retrospectively included 135 gastric cancer patients who received neoadjuvant chemotherapy at Çukurova University Balcalı Hospital between January 2018 and December 2023. Preoperative CRP/albumin and CEA/albumin ratios were compared according to treatment response and multivariate logistic regression analysis was performed to determine the potential importance of these ratios in predicting pathological response. Results : The mean age of the 135 patients was 58.79 ± 10.83 (min = 26-max = 78). The CRP/albumin and CEA/albumin ratios were found to be significantly lower in patients who did not respond to neoadjuvant therapy. Each 1-unit increase in the CRP/albumin ratio was associated with a 1.16-fold decrease in the odds of pathological complete response to neoadjuvant therapy. Both CRP/albumin and CEA/albumin ratios were found to be significant in distinguishing neoadjuvant therapy response. The optimal cut-off value was 2.74 for the CRP/albumin ratio (sensitivity = 60%, specificity = 78.4%) and 1.40 for the CEA/albumin ratio (sensitivity = 74.2%, specificity = 67.6%). Values below these cut-off points favored neoadjuvant therapy response. Pathological complete response to neoadjuvant therapy was 4.75 times higher in patients with a CRP/albumin ratio below 2.74 and 5.14 times higher in patients with a CEA/albumin ratio below 1.40. Conclusions : Findings demonstrate that in patients with locally advanced gastric cancer receiving neoadjuvant treatment, CRP/Albumin and CEA/Albumin ratios are significant markers of pathological response.
- Published
- 2024
- Full Text
- View/download PDF
62. Efficacy of first-line CDK 4-6 inhibitors in premenopausal patients with metastatic breast cancer and the effect of dose reduction due to treatment-related neutropenia on efficacy: a Turkish Oncology Group (TOG) study.
- Author
-
Yildirim HC, Kapar C, Koksal B, Seyyar M, Sanci PC, Guliyev M, Perkin P, Buyukkor M, Yaslikaya S, Majidova N, Keskinkilic M, Ozaskin D, Avci T, Gunes TK, Arcagok M, Topal A, Keskin GSY, Kavgaci G, Yildirim N, Celayir OM, Avci N, Aslan F, Alkan A, Erciyestepe M, Cengiz M, Pehlivan M, Gulmez A, Beypinar I, Basoglu Tuylu T, Kayikcioglu E, Chalabiyev E, Turhal S, Guzel HG, Ayas E, Sahbazlar M, Dulgar O, Demir H, Yavuzsen T, Bayoglu V, Kivrak Salim D, Ozturk B, Ozdemir F, Kara O, Oksuzoglu B, Bal O, Demirci NS, Yilmaz M, Cabuk D, and Aksoy S
- Abstract
The only phase 3 study on the effectiveness of CDK 4-6 inhibitors in first-line treatment in premenopausal patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer is the MONALEESA-7 study, and data on the effectiveness of palbociclib is limited. Data are also limited regarding the effectiveness of CDK 4-6 inhibitors in patients whose dose was reduced due to neutropenia, the most common side effect of CDK 4-6 inhibitors. In our study, we aimed to evaluate the effectiveness of palbociclib and ribociclib in first-line treatment in patients with premenopausal metastatic breast cancer and the effect of dose reduction due to neutropenia on progression-free survival. Our study is a multicenter, retrospective study, and factors affecting progression-free survival (PFS) were examined in patients diagnosed with metastatic premenopausal breast cancer from 29 different centers and receiving combination therapy containing palbociclib or ribociclib in the metastatic stage. 319 patients were included in the study. The mPFS for patients treated with palbociclib was 26.83 months, and for those receiving ribociclib, the mPFS was 29.86 months ( p = 0.924). mPFS was 32.00 months in patients who received a reduced dose, and mPFS was 25.96 months in patients who could take the initial dose, and there was no statistical difference ( p = 0.238). Liver metastasis, using a fulvestrant together with a CDK 4-6 inhibitor, ECOG PS 1 was found to be a negative prognostic factor. No new adverse events were observed. In our study, we found PFS over 27 months in patients diagnosed with premenopausal breast cancer with CDK 4-6 inhibitors used in first-line treatment, similar to post-menopausal patients. We did not detect any difference between the effectiveness of the two CDK 4-6 inhibitors, and we showed that there was no decrease in the effectiveness of the CDK 4-6 inhibitor in patients whose dose was reduced due to neutropenia.
- Published
- 2024
- Full Text
- View/download PDF
63. Anti-Müllerian hormone: A novel biomarker for detecting bovine freemartinism.
- Author
-
Koca D, Nak Y, Sendag S, Nak D, Turgut AO, Avcılar T, Ekici ZM, Cetin N, Bagci K, Aktar A, Sagirkaya H, Alcay S, and Wehrend A
- Subjects
- Pregnancy, Cattle, Animals, Female, Freemartinism, Fetus, Mullerian Ducts, Biomarkers, Anti-Mullerian Hormone, Cattle Diseases
- Abstract
The anti-Müllerian hormone (AMH) indicates ovarian reserve in cattle, maintaining a consistent trajectory post-puberty. In heterosexual pregnancies, the development of the Müllerian duct in female foetuses is inhibited, resulting in an anticipated minimal or absent ovarian reserve capacity. This investigation aimed to compare AMH levels in healthy Holstein heifers that had reached puberty with those of freemartin animals of the same breed and age. The study incorporated Holstein heifers reaching puberty between 11 and 15 months of age in Group 1 (G1, n = 20) and freemartin animals in Group 2 (G2, n = 19, 16). AMH measurements (AMH-1/AMH-2) were recorded at 12-day intervals for the study participants. Notably, AMH levels in three freemartin animals could not be detected, prompting statistical analysis based on measurements from the remaining 16 freemartin animals in G2. A statistically significant correlation was observed between two separate measurements in G1 and G2 (p < .001). Furthermore, AMH-1 and AMH-2 levels were statistically higher in G1 than in G2 (p < .001). In G1, AMH-1 levels ranged from 227 to 677 pg/mL, with an average of 367.3 ± 25.5 pg/mL, and AMH-2 levels ranged from 234 to 645 pg/mL, with an average of 380.8 ± 24.4 pg/mL. Conversely, in G2, AMH-1 levels ranged from 10 to 72 pg/mL, with an average of 26.8 ± 4.44 pg/mL, and AMH-2 levels ranged from 12 to 68 pg/mL, with an average of 28.75 ± 4.18 pg/mL. The mean AMH levels in G1 were approximately 14 times higher than in G2 (p < .001). Consequently, ROC analysis utilizing AMH-1 and AMH-2 data established cut-off values of ≤72 and ≤ 68 pg/mL respectively for distinguishing freemartin animals. In conclusion, AMH could be used as a reliable biomarker for identifying Holstein freemartin animals., (© 2024 The Authors. Reproduction in Domestic Animals published by Wiley-VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
64. Evaluation of serum anti-Müllerian hormone concentrations following treatment with vitamin D in Holstein Friesian heifers.
- Author
-
Koca D, Nak Y, Sendag S, Nak D, Avcılar T, Sahin ME, Arslan T, Ozyigit MO, and Wehrend A
- Subjects
- Humans, Cattle, Female, Animals, Anti-Mullerian Hormone, Cholecalciferol, Ovarian Follicle, Vitamin D pharmacology, Peptide Hormones
- Abstract
Anti-Müllerian hormone (AMH) levels in the blood of dairy cattle are associated with the count of antral follicles (AFC), ovarian function. Numerous studies, particularly in human medicine, have shown that vitamin D3 (Vit D3) has a positive effect on AMH levels. To our knowledge, the effects of Vit D3 on serum AMH levels in heifers have not been investigated. The goal of the current study was to evaluate the concentrations of serum AMH in dairy heifers following Vit D3 treatment. The study included 20 healthy non-pregnant Holstein Friesian heifers. These animals came to estrus at least once. All heifers received a single intramuscular dosage of 5 million IU Vit D3 (Cholecalciferol). Blood samples were collected from the coccygeal veins of all animals before and after Vit D3 injection (days 7, 14, and 28) for the measurement of AMH and 25(OH)D concentrations. In our analysis, we observed that after exogenous Vit D3 administration, circular 25(OH)D increased constantly (up to day 28 after Vit D3 injection) in all animals. On day 28, AMH concentrations saw a 10% increase in comparison with those measured the day before the Vit D3 injection. However, a comparison of AMH concentrations measured across days did not reveal statistically significant differences between Day 0, 7, 14, and 28 levels (p = .10). Furthermore, no statistical correlation was observed between the pairs (age-AMH) and (weight-AMH). Considering all times, no correlation was found between 25(OH)D and blood AMH levels. These findings demonstrated that exogenous Vit D3 did not affect serum AMH in Holstein Friesian heifers., (© 2023 The Authors. Reproduction in Domestic Animals published by Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF
65. [Comparison of different resuscitation methods for newborn calves after dystocia].
- Author
-
Homberg J, Sendag S, Koca D, Cetin N, and Wehrend A
- Subjects
- Pregnancy, Female, Animals, Animals, Newborn, Dystocia therapy, Dystocia veterinary
- Abstract
Objective: This study aimed to compare the use of hand-powered vacuum pumps and the suspension by the hind legs within the scope of resuscitating newborn dystocial calves., Material and Methods: For this study, data were collected from 60 dystocial calves of different breeds. Various reanimation methods were employed to these calves immediately after birth. In group I (n=20), the hand-powered vacuum pump from HK-Rheintechnik (Neuwied, Deutschland) was used to remove mucus and amniotic fluid from the respiratory tract. In group II (n=20), the McCulloch Medical (Elmwood, England) hand-powered vacuum pump was used to remove mucus and amniotic fluid from the respiratory tract. In group III (n=20) 10 to 12 liters of cold water were poured over the neck of 20 calves immediately after birth. In addition, the calves were suspended by the hind legs via a gate or a pole, so that the head hung downwards vertically. The calves' Time to Sternal Recumbency (T-SR) of the calves was measured following the different resuscitation procedures in order to assess their vitality. In addition, the calves were examined segmentally at one-hour post natum. Furthermore, the calves were examined clinically on the seventh day of life. In addition, we investigated whether confounding variables such as calf sex, dam parity, obstetric intervention, and the season affected T-SR., Results: T-SR ranged from 1.5 to 10.5 minutes. There was no difference between the three initial treatment procedures (p=0.07). However, the T-SR of calves treated with a hand-powered vacuum pump tended to be shorter. No statistically significant difference between the pulse rates (p=0.73), respiratory rates (p=0.13), and rectal temperature (p=0.65) of the animals in the three groups on the first and seventh day of life was evident. There was no statistically significant difference in the incidence of the diseases up to the seventh day of life between the individual study groups., Conclusion and Clinical Relevance: The present study was able to show that the use of hand-powered vacuum pumps is at least equivalent to suspending calves. When using hand-powered vacuum pumps, the girth of the muzzle must be taken into account, as this can limit their utility., Competing Interests: Die Autoren bestätigen, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
66. Effect of uterine torsion intrapartum on concentrations of placental estrogens and progesterone in cattle.
- Author
-
Sendag S, Sickinger M, Arslan T, Schuler G, and Wehrend A
- Subjects
- Cattle, Pregnancy, Female, Animals, Placenta, Uterus, Steroids, Progesterone, Estrogens pharmacology
- Abstract
Objective: The current study investigates how uterine torsion influences placental oestrogens and progesterone blood concentrations in intrapartum cows. Our research tests the hypothesis that intrapartum uterine torsion impairs the ability of the placenta to synthesize steroids and may also suppress the release of synthesized steroids into the maternal circulation., Methods: The study included a total number of 37 intrapartum dairy cows of various breeds and ages. These animals were transported to our clinic by their owners. Furthermore, general and obstetrical examinations of all these animals were performed in our clinic. The uterine torsion (UT) group consisted of 20 animals. The presence of UT was verified during clinical general examinations by vaginal and transrectal examination. The comparison (C) group included 17 animals whose birth was undisturbed or could be terminated with moderate obstetrical assistance. The clinical examination of group C animals showed no problems with their general health and genital organs. Blood samples were collected immediately after the initial obstetrical examination from 37 cows for radioimmunological measurement of estradiol-17β (E2), free total estrogen (FTE), conjugated total estrogen (CTE), and progesterone (P4)., Results: In terms of P4, there was no statistical difference between the two groups. For all estrogen parameters, however, concentrations were significantly lower in the UT group than in the C group. In the correlation analysis, there was a significant correlation between the P4 and the FTE in the C group. Furthermore, the positive correlation between all estrogen parameters in the UT group was significant. In group C, significant positive correlations were found apart from the correlation between E2 and CTE., Conclusions: The results are consistent with the hypothesis and suggest that in UT animals processes dependent on estrogens or other placental hormones may be impaired during the peri- or postpartum period., (© 2023 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
67. Comparison of the Efficacy and Safety of 3 Months of CAPOX Followed by 3 Months of Capecitabine and 6 Months of CAPOX/FOLFOX in the Adjuvant Treatment of Low-Risk Stage III Colon Cancer Treated Surgically.
- Author
-
Bardakci M, Demirtas Esmer D, Hafizoglu E, Yaslikaya S, Genc TB, Ozcelik M, Erdat EC, Hendem E, Buyukbayram ME, Alaca Topcu Z, Kalkan Z, Yildirim N, Celebi A, Ergun Y, Paydas S, Tatli AM, Karakas H, Koseci T, and Sendur MAN
- Abstract
Introduction: In the adjuvant treatment of low-risk stage III colon cancer treated surgically, 3 months of CAPOX followed by 3 months of capecitabine is not a common clinical practice. Since there are no data on this practice in the literature, we have no idea how often it is used. However, it should be noted that this application is used in some centers due to the cumulative neurotoxicity of oxaliplatin but there are insufficient data in the literature on its efficacy., Methods: The data of patients with colon cancer treated surgically who were followed up in 12 different oncology centers in Turkey between November 2004 and June 2022 were analyzed retrospectively., Results: The study included 194 patients. The treatment arms were as follows: 3 months of CAPOX followed by 3 months of capecitabine = arm A and CAPOX/FOLFOX (6 months) = arm B. There were 78 patients (40.2%) in arm A and 116 patients (59.8%) in arm B. The median age and sex distribution were similar between the treatment arms. The median follow-up period of all patients was 34.4 months (95% confidence interval, 29.1-39.7). When arm A was compared with arm B, 3-year disease-free survival (DFS) was 75.3% versus 88.4% and 5-year DFS was 75.3% versus 82.8%, respectively. There were similar DFS outcomes between the treatment arms (p = 0.09). Rates of any grade of neuropathy were numerically lower in arm A, but the difference between the treatment arms was not statistically significant (51.3% vs. 56.9%; p = 0.44). The frequency of neutropenia was similar between the treatment arms., Conclusion: In this study, the efficacy and safety of the 3 months of CAPOX followed by 3 months of capecitabine chemotherapy regimen in the adjuvant treatment of low-risk stage III colon cancer treated surgically were proven. This result may also support the discontinuation of oxaliplatin at 3 months while continuing fluoropyrimidines, which is a common clinical practice but lacks sufficient data., (© 2023 S. Karger AG, Basel.)
- Published
- 2023
- Full Text
- View/download PDF
68. Effect of a single meloxicam administration on newborn Holstein-Friesian dystocia calves: Field results from the first 10 days of life.
- Author
-
Kunz F, Sendag S, Yildiz M, Failing K, and Wehrend A
- Abstract
Background and Aim: Calves have increased morbidity and mortality rates after dystocia. One cause is pain during birth, which reduces their colostrum intake. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may break this causality. This study aimed to determine the consequences of a single administration of the NSAID meloxicam to dystocia calves after birth., Materials and Methods: Fifty Holstein-Friesian calves born with dystocia from four dairy cattle farms were included in this study. The animals were randomized into two groups. The animals in Group I (n=25, treatment group) received subcutaneous 0.5 mg meloxicam/kg body weight 2-8 h after birth. The animals in Group II (n=25, control group) received a control substance (Amynin
® , bovine infusion solution, Merial) with the same volume. The newborn calves were clinically examined on the 1st and 10th days of life. The information regarding the days in between was gathered by questioning the farmer., Results: There was a significant difference (p=0.04) only in calves with thin, mushy fecal consistency on the 10th day in the treatment group compared with the control group. Moreover, meloxicam had no effect on dystocia calves., Conclusion: Since NSAID administration did not produce a significant clinical effect, its necessity is questionable. Further studies should examine how modifying its application time would have an effect. The primary indicators of well-being, such as pain indicators in the blood, were not measured; however, these should be considered in subsequent studies., Competing Interests: No person from Boehringer Ingelheim, Germany, was involved in the study at any stage and publication of the manuscript., (Copyright: © Kunz, et al.)- Published
- 2022
- Full Text
- View/download PDF
69. Predictors of e-democracy applicability in Turkish K-12 schools.
- Author
-
Sendag S, Toker S, Uredi L, and Islim OF
- Abstract
Today, the COVID-19 pandemic has paved the way for a more democratic climate in K-12 schools. Administrators and teachers have had to seek out new ways through which to interact. This raises two questions; "What about the quality of interaction and participation in decision-making?" and "Which factors affect the level of participation in decision-making?" The aim of the current research is to determine the factors that predict the applicability level of e-democracy (i.e., "reporting and declaring opinions" and "decision-making") in K-12 schools. An associational research design was used in order to attain the main goal of the study, with Discriminant Function Analysis (DFA) technique used to analyze the factors predicting the applicability level of e-democracy. Data were collected from a total of 765 inservice K-12 teachers through a questionnaire developed by the researchers. DFA results showed "motivation to participate," "the level of participatory democracy in the country," and higher levels of the "use of Twitter" as the significant determinants of different levels of e-democracy application. Moreover, the results also indicated that those participants with the belief of e-democracy's applicability at the decision-making level found the "motivation level of stakeholders" to be the most critical. Their level of Twitter use was higher. They also believed that the level of participatory democracy in the country was at a higher level. Another result of the DFA pointed to "security and ethical issues," and lower levels of the "use of Twitter" as factors differentiating the group believing that e-democracy can be applicable with reporting and the declaration of opinions to administrators from the other groups. The discussions highlighted the critical role of participation level in e-democracy within K-12 schools., (© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.)
- Published
- 2022
- Full Text
- View/download PDF
70. The effect of GnRH on the pregnancy ratio in low-yielding local race cows: comparison of different injection times.
- Author
-
Uslu BA, Kocyigit A, Sendag S, Gülyüz F, and Wehrend A
- Subjects
- Animals, Dinoprost pharmacology, Female, Ovulation drug effects, Pregnancy, Random Allocation, Time Factors, Cattle physiology, Gonadotropin-Releasing Hormone administration & dosage, Insemination, Artificial veterinary, Luteolysis, Pregnancy Rate
- Abstract
The objective of this article was to investigate the efficiency of GnRH administrations at different time points after induced luteolysis on pregnancy rates in low-yielding subfertile cows. One thousand six hundred and ten healthy and subfertile dairy cows of different ages and races were used in this study. Cows were randomly divided into 4 groups. Estrus cycles were synchronized by two, with 11-day intervals, injections of the prostaglandin F2α-analogue (PG). The artificial inseminations (AIs) of all animals were achieved at the 72nd and 96th hours following the last PG injection. The animals in groups I (n 257), II (n 337), and III (n 675) were used for the administration of a single dose of GnRH at different time points. Accordingly, GnRH was applied at 48th, 64th, and 72nd hours following the last PG injection in groups I, II, and III, respectively. Group IV was accepted as a control without GnRH injection (n 341). The pregnancy rates in groups I, II, III, and IV after transrectal pregnancy examinations were found to be 89.88%, 91.09%, 83.25%, and 77.12%, respectively. In our study, maximal pregnancy rates could be obtained with GnRH injections performed at 48th and 64th hours following luteolysis induction (P < 0.001). There was a 6-8% decrease in pregnancy rates due to the injection of GnRH in the 72nd hour (P < 0.001). These dramatic losses and gains in pregnancy rates in our study emphasized the necessity of taking the time of injection into account when using GnRH to stimulate ovulation. It can be said that the success of GnRH stimulation of ovulation is directly related to the follicle wave dynamics at the time of injection point and the character of a dominant follicle.
- Published
- 2020
- Full Text
- View/download PDF
71. [Administration of meloxicam to cows experiencing dystocia does not increase the incidence of retained placenta].
- Author
-
Kunz F, Koca D, Failing K, Wehrend A, and Sendag S
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Cattle, Dystocia drug therapy, Female, Incidence, Injections, Subcutaneous veterinary, Meloxicam adverse effects, Placenta, Retained chemically induced, Pregnancy, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Cattle Diseases chemically induced, Cattle Diseases drug therapy, Dystocia veterinary, Meloxicam administration & dosage, Placenta, Retained veterinary
- Abstract
Objective: The post partum use of analgesics in cows has increased in consequence to society's increased awareness of animal welfare. However, it is known that the post partum administration of a subset of nonsteroidal anti-inflammatory drugs to cows may lead to an increased rate of retained placenta. Therefore, the aim of this study was clarify, whether a single administration of meloxicam to cows that experienced dystocia results in an increased rate of this disease., Material and Methods: The study was conducted in 63 Holstein-Friesian cows in 4 farms with random allocation into 2 groups: In animals of the treatment group (n = 27) a single subcutaneous injection of meloxicam (0.5 mg/kg) was administered within 2-8 hours after calving. The animals of the control group (n = 36) received the same volume of a bovine infusion solution (Amynin
® , bovine infusion solution, Boehringer Ingelheim) subcutaneously. A clinical examination of the cows was performed on the day of parturition and on the 21st day post partum. Findings on the days in between were obtained by questioning of the farmers. The exact Fisher-test was calculated in order to test for statistical differences between the treatment and control groups., Results: In cows of the treatment group, retained placenta was not observed more frequently than in cows of the control group., Conclusion and Clinical Relevance: A single administration of meloxicam to cows that experienced dystocia does not increase the incidence of retained placenta., Competing Interests: Die Firma Boehringer Ingelheim hat die Studie finanziell und durch die Bereitstellung von Metacam® unterstützt. Die Autoren bestätigen, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)- Published
- 2019
- Full Text
- View/download PDF
72. Postpartum uterus involution observed by real-time ultrasound scanning and vaginal cytology in Van cats.
- Author
-
Sendag S, Alan M, Eski F, Uslu S, Uslu BA, and Wehrend A
- Subjects
- Animals, Female, Postpartum Period, Pregnancy, Ultrasonography, Doppler veterinary, Uterus pathology, Vagina pathology, Cats physiology, Pregnancy, Animal physiology, Uterus diagnostic imaging, Vagina diagnostic imaging
- Abstract
Objectives: The objective was to investigate postpartum uterus involution by real-time ultrasonography and vaginal cytology in Van cats., Methods: This study included 15 healthy Van cats belonging to the Van Cat Research Centre (Yuzuncu Yil University, Van, Turkey). Starting 24 h postpartum, ultrasonographic measurements were performed on the placental and interplacental uterine horn regions every day. Decreases in the diameters and uterine content were considered as criteria for uterine involution. Vaginal discharge samples were collected every day for 4 weeks postpartum. The smears were stained with Papanicolaou stain., Results: The average diameters of placental and interplacental regions (IPRs) in the uterine horns were 3.12 ± 0.29 cm and 2.36 ± 0.43 cm, respectively, at 24 h postpartum. Placental regions (PRs) shrank faster than IPRs. At 48 h postpartum, it became difficult to distinguish PRs from IPRs in the uterine horns. The uterine horns could be seen in the abdominal cavity up to 5.60 ± 0.99 days postpartum. The mean of the last assessable diameter of the uterine horns from days 4 to 7 in all cats was 0.49 ± 0.07 cm. The vaginal epithelial cells appeared to be under the effect of oestrogen for 4 weeks postpartum., Conclusions and Relevance: The morphological involution of the uterus completes, to a large extent, within the first 48 h postpartum in Van cats. A more detailed hormonal analysis would contribute greatly to the understanding of the physiological processes involved in this period. Although postpartum involution appeared complete by 5.60 ± 0.99 days after parturition in Van cats, histological verification of this finding is needed., (© The Author(s) 2015.)
- Published
- 2016
- Full Text
- View/download PDF
73. Effect of flunixin meglumine or prostaglandin E2 treatment 15 days after breeding on fertility in Saanen does.
- Author
-
Cetin Y, Kocamuftuoglu M, Ozyurtlu N, Kucukaslan I, Sendag S, and Wehrend A
- Subjects
- Animals, Clonixin pharmacology, Corpus Luteum drug effects, Female, Fertility, Luteal Phase, Pregnancy, Pregnancy Rate, Breeding methods, Clonixin analogs & derivatives, Dinoprostone pharmacology, Goats physiology, Prostaglandin Antagonists pharmacology
- Abstract
The objective of this study was to determine the effects of timely injections of flunixin meglumine (FM) or vaginal application of prostaglandin E2 (PgE2) on pregnancy, fertility, fecundity, and prolificacy rates in Saanen goats. One hundred and sixty-three nonlactating Saanen does were treated with a flugestone acetate (20 mg)-containing intravaginal sponge for 12 days. They also received eCG (400 IU) and a PGF2α analogue (50 μg) 10 days after progestagen priming. Does detected in estrus were mated and assigned randomly to one of three treatment groups. The PgE2 group (N = 40) received PgE2 (2.5 mg) intravaginally 15 days after mating. The FM group (N = 54) received flunixin meglumine (total dose, 100 mg) intramuscularly 15 days after mating. Flunixin meglumine was administered at 9:00 AM. Animals in the control group (N = 69) received no treatment. Pregnancy was diagnosed using transrectal ultrasonography (B-mode at 8 MHz) 30 days after mating. The pregnancy rate was significantly greater (P < 0.01) after 30 days in goats treated with PgE2 and also in the control group than in those treated with FM (67.5%, 59.4%, and 42.5%, respectively). The pregnancy rate did not differ between the PgE2 and the control group. The pregnancy and fertility rate were lowest in the FM group compared with the other groups. There was no significant difference in the prolificacy rate among experimental groups. In conclusion, our results showed that FM administration during a late luteal phase is detrimental to early pregnancy in goats., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
74. [Vulval hypoplasia in an alpaca cria - first case report in Germany].
- Author
-
Schünemann M, Böhm J, Sendag S, and Wehrend A
- Subjects
- Animals, Female, Germany, Urinary Catheterization veterinary, Urination Disorders etiology, Urination Disorders therapy, Urination Disorders veterinary, Vulva surgery, Animals, Newborn abnormalities, Camelids, New World abnormalities, Vulva abnormalities
- Abstract
This is the first German case report of an alpaca cria suffering from a congenital vulvahypoplasia. Symptoms, diagnostics and therapy are described. The 24-hours-old cria was referred to the hospital due to reduced general condition and colic. The existent vulvahypoplasia led to impaired urination, causing further complications such as urovagina and urinary stasis up to the renal pelvis. Surgical construction of the rima vulvae cured the cria. As indicated by several cases published on the clinical picture of vulvahypoplasia during recent years, this congenital deformation could become an increasing problem in the alpaca population.
- Published
- 2012
75. Effects of eCG and FSH on ovarian response, recovery rate and number and quality of oocytes obtained by ovum pick-up in Holstein cows.
- Author
-
Sendag S, Cetin Y, Alan M, Hadeler KG, and Niemann H
- Subjects
- Animals, Cattle, Cell Count, Cumulus Cells drug effects, Cumulus Cells physiology, Female, Ovary physiology, Ovulation Induction methods, Ovulation Induction veterinary, Ovum drug effects, Ovum physiology, Quality Control, Follicle Stimulating Hormone pharmacology, Gonadotropins, Equine pharmacology, Oocyte Retrieval methods, Oocyte Retrieval veterinary, Ovary drug effects, Ovum cytology
- Abstract
The goal of the present study was to compare the ovarian response, oocyte yields per animal, and the morphological quality of oocytes collected by ultrasound guided follicular aspiration from Holstein cows treated either with FSH or eCG. Twenty four normal cyclic, German Holstein cows were randomly divided into two groups. Fourteen cows received 3000 IU eCG on day-4 prior to ovum pick-up (OPU) (day 0), 2 days later (day-2), 625 microg cloprostenol was administered. On day-1 GnRH was administered i.m. and 24h later OPU (day 0) was performed. In ten cows a total dose of 500 IU follicle stimulating hormone (Pluset) was administered intramuscularly in a constant dosage for 4 days with intervals of 12h, starting on day-5. Luteolysis was induced by application of 625 microg cloprostenol on day-2. On day-1 (24h after the last FSH treatment) GnRH was administered i.m. and 24h later OPU (day 0) was performed. Ovarian follicles were visualized on the ultrasound monitor, counted and recorded. All visible antral follicles were punctured. Recovered oocytes were graded morphologically based on the cumulus investment. Average follicle number in ovaries was higher in FSH group than eCG group (p<0.05). Oocyte yields per animal did not differ between FSH and eCG groups. The proportion of grade A oocytes was higher in the FSH group in the than eCG group (p<0.05). Likewise, rate of grade C oocytes in FSH group were lower than eCG group (p<0.05). In conclusion, these results suggest that ovarian response, follicle number in ovaries and oocyte quality are affected by the type of gonadotropin and FSH is better alternative than eCG for OPU treatment.
- Published
- 2008
- Full Text
- View/download PDF
76. [Short communication: ultrasonographic examination of the abomasal position in dairy cows during the peripartal period].
- Author
-
Sendag S, Seeger T, and Wehrend A
- Subjects
- Animals, Cattle physiology, Female, Pregnancy, Ultrasonography methods, Ultrasonography veterinary, Abomasum diagnostic imaging, Cattle anatomy & histology, Postpartum Period, Pregnancy, Animal physiology
- Abstract
The objective of this study was to document the abomasal position during the peripartal period by ultrasonographic measurement to get more data about the topographic dynamic. In 12 dairy cows the abomasal position was measured daily from the 5th day before calving up to the 5th day after calving by a transabdominal ultrasonographic examination (5 MHz convex transducer). The abomasal position was described by means of 3 measured distances: (a) the distance between the cranial margin of the abomasum and the xiphoid cartilage, (b) the distance between the right margin of the abomasum and the median line and (c) the distance between the left margin of the abomasum and the median line. Prepartal the abomasal position was different from the position during the postpartal period. Its position was more cranially (p < 0.05) and more right laterally (p < 0.05). The left margin was not detectable at the left side of the mid-line ante partum. Directly after calving the left margin of the abomasum was found left of the linea alba (p < 0.05). These results show that there is a great influence of the gravid uterus on the abomasal position. The abomasum is positioned more cranially and more right lateral during the end of pregnancy. This position changes immediately after calving.
- Published
- 2005
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.