338 results on '"Sebti, Saïd M."'
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52. Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity
53. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
54. Inhibition of rho GTPases using protein geranylgeranyltransferase I inhibitors
55. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
56. Farnesyltransferase inhibitors
57. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
58. Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting
59. Peptidomimetic inhibitors of farnesyltransferase
60. Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase
61. Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture
62. Human pSTAT3-Inhibited Itregs Prevent Gvhd, Maintain Anti-Leukemia Immunity, and Increase Their Potency after Metabolic Reprogramming
63. GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
64. Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt
65. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction
66. Design and synthesis of AApeptides: A new class of peptide mimics
67. Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs
68. Protein Prenylation in Trypanosomatids: A New Piggy-Back Medicinal Chemistry Target for the Development of Agents Against Tropical Diseases
69. Peptidomimetic-Based Inhibitors of Farnesyltransferase
70. Farnesyltransferase and Geranylgeranyltransferase I Inhibitors as Novel Agents for Cancer and Cardiovascular Diseases
71. Prenyltransferase Inhibitors as Radiosensitizers
72. Abstract 1640: A novel small molecule inhibitor of lysophosphatidic acid acyltransferase-beta inhibits pancreatic cancer cell proliferation and mTOR signaling
73. Discovery of PI-1840, a Novel Noncovalent and Rapidly Reversible Proteasome Inhibitor with Anti-tumor Activity
74. Identification of a disruptor of the MDM2-p53 protein–protein interaction facilitated by high-throughput in silico docking
75. Lysophosphatidic Acid Acyltransferase Beta Regulates mTOR Signaling
76. Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors
77. A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
78. Development of new N-arylbenzamides as STAT3 dimerization inhibitors
79. RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
80. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
81. Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors
82. Abstract 3904: Pyridylthiazole-based ureas as inhibitors of Rho-associated protein kinases
83. Abstract 1854: Lysophosphatidic Acid Acyltransferase-Beta contributes to proliferation and anchorage-independent growth in pancreatic adenocarcinoma
84. Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors
85. Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb–Raf-1 Interaction as a Novel Target for Metastatic Disease
86. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)
87. Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors
88. Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice
89. Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors
90. The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner
91. Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
92. Abstract 732: Targeting the Bcl-2/BH3 protein-protein interaction: Identification, design, and synthesis of new selective inhibitors of the Mcl-1/BH3 interaction
93. Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27 Kip1 Phosphorylation on Thr187 and Accumulates p27 Kip1 in the Nucleus: Implications for Breast Cancer Therapy
94. Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I
95. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains
96. Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics
97. Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders
98. Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure−Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation
99. Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds
100. Module Assembly for Protein-Surface Recognition: Geranylgeranyltransferase I Bivalent Inhibitors for Simultaneous Targeting of Interior and Exterior Protein Surfaces
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