51. Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3
- Author
-
Daniel L. Cheney, Diane Hollenbaugh, Robert M. Townsend, Scott H. Watterson, Shelley K. Ballentine, Joel C. Barrish, Katherine A. Rouleau, Edwin J. Iwanowicz, Zhongqi Shen, Catherine A. Fleener, and T. G. Murali Dhar more...
- Subjects
Indoles ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Quinolones ,Biochemistry ,Aldehyde ,Chemical synthesis ,Structure-Activity Relationship ,Glucuronides ,IMP Dehydrogenase ,IMP dehydrogenase ,Drug Discovery ,Humans ,Enzyme Inhibitors ,Molecular Biology ,chemistry.chemical_classification ,Indole test ,biology ,Bicyclic molecule ,Hydrogen bond ,Organic Chemistry ,Hydrogen Bonding ,Stereoisomerism ,Isoenzymes ,Enzyme ,chemistry ,Enzyme inhibitor ,Immune System ,biology.protein ,Molecular Medicine ,Mitogens ,Cell Division - Abstract
The development of a series of novel indole-based inhibitors of 5'-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined. more...
- Published
- 2003