457 results on '"Scleredema Adultorum"'
Search Results
52. Idiopathic scleredema
- Author
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Elise Ng, Rachel Rosenstein, Vitaly Terushkin, Shane Meehan, and Miriam Keltz Pomeranz
- Subjects
Male ,Back ,Scleredema Adultorum ,Humans ,Dermatology ,General Medicine ,Middle Aged - Abstract
Scleredema, which also is known as scleredemaadultorum of Buschke, is an uncommonsclerodermiform condition that is characterizedby progressive thickening and hardening of theskin due to excessive dermal mucin and collagendeposition. The clinical course is variable, andprogression of disease may lead to functionalimpairment with limitations in mobility. The etiologyand pathogenesis are unknown although severalwell-known associations include streptococcalinfection; diabetes mellitus, particularly withmetabolic syndrome; and monoclonal gammopathy.We present a case of scleredema in a 52-year-oldman with no identifiable associated condition,who experienced improvemement with UVBphototherapy.
- Published
- 2016
53. Letter on ‘European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis’
- Author
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Ilona A. Dekkers, Patrick B. Mark, Peter J. Blankestijn, Giles Roditi, and Tim Leiner
- Subjects
Nephrogenic Fibrosing Dermopathy ,medicine.medical_specialty ,030232 urology & nephrology ,Dermatology ,Skin Diseases ,Scleroderma ,030218 nuclear medicine & medical imaging ,Scleroderma, Localized ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,Scleromyxedema ,medicine ,Humans ,Undifferentiated Connective Tissue Diseases ,Scleroderma, Systemic ,Scleredema Adultorum ,business.industry ,Undifferentiated connective tissue disease ,Guideline ,medicine.disease ,Infectious Diseases ,Nephrogenic systemic fibrosis ,Scleredema ,business ,RC - Abstract
We read with interest the guidelines recently published on sclerosing diseases of the skin (Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis)[1, 2]. However, we are concerned that the guideline recommendations proposed for prevention of nephrogenic systemic fibrosis (NSF) are potentially dangerous. Although we recognise the challenges in constructing comprehensive guidelines, we are concerned that this may be because the guidelines have not involved a multidisciplinary team.
- Published
- 2018
54. The differential diagnosis of systemic sclerosis
- Author
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Susanna Fistarol and Alan Tyndall
- Subjects
medicine.medical_specialty ,MEDLINE ,Scleroderma ,Nephrogenic Fibrosing Dermopathy ,Diagnosis, Differential ,Scleroderma, Localized ,Rheumatology ,Internal medicine ,Eosinophilia ,medicine ,Humans ,Connective Tissue Diseases ,skin and connective tissue diseases ,Scleroderma, Systemic ,Synovitis ,Scleredema Adultorum ,integumentary system ,business.industry ,medicine.disease ,Dermatology ,Treatment modality ,Scleromyxedema ,medicine.symptom ,Differential diagnosis ,business ,Rheumatism - Abstract
The new American College of Rheumatology/European League Against Rheumatism classification criteria will enable earlier diagnosis and, therefore, the use of newer treatment modalities for systemic sclerosis (SSc). It is therefore critical to exclude non-SSc causes for diffuse skin thickening as early as possible.The recently described gadolinium-induced nephrogenic systemic fibrosis may mimic SSc as may other conditions which require a different treatment strategy. Recently, treatment with immunoablation and autologous stem cell transplantation has been shown to significantly benefit some patients with conditions such as scleromyxoedema and SSc. The more accurate measurement of SSc-specific autoantibodies such as topoisomerase 1, centromere and RNA polymerase has recently allowed a more precise subclassification of SSc with implications for treatment and prognosis.Skin thickening is a nonspecific manifestation of many different processes including (rarely) early scleroderma, which is mostly symmetrical and associated with Raynaud's phenomenon, nailfold capillaroscopic changes and antinuclear antibodies. If the latter three factors are absent, then other conditions must be excluded, the commonest being eosinophilic fasciitis. Skin biopsy (looking for eosinophil infiltration, increased mucin or amyloid deposition), SSc-specific autoantibodies or paraproteins in blood and a careful medical history and system screening will exclude nonscleroderma conditions.
- Published
- 2013
55. Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin.
- Author
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Svoboda SA and Shields BE
- Subjects
- Humans, Diabetes Mellitus, Type 2 complications, Hyperglycemia complications, Hyperinsulinism etiology, Scleredema Adultorum, Skin Diseases etiology
- Abstract
Hyperglycemia is defined by excess blood glucose and, when persistent, may lead to prediabetic and diabetic states. Insulin is a hormone produced by the beta cells of the pancreas in response to elevated blood glucose. Dysregulated insulin secretion or clearance results in hyperinsulinemia, which also is closely associated with type 2 diabetes mellitus (T2DM) and metabolic disturbances. Hyperglycemia and hyperinsulinemia are endemic within the United States and impart considerable morbidity and mortality. Cutaneous manifestations of chronic hyperglycemia and hyperinsulinemia include acanthosis nigricans (AN), diabetic dermopathy (DD), scleredema diabeticorum (SD), ichthyosiform skin changes, acrochordons, and keratosis pilaris (KP). Necrobiosis lipoidica (NL), bullosis diabeticorum (BD), and generalized granuloma annulare (GA) are more rarely reported in association with hyperglycemia and hyperinsulinemia; however, the strength of these associations remains unclear. It is crucial for dermatologists to recognize these cutaneous manifestations, as they may be the first signs of metabolic syndrome and insulin resistance. Early identification and management of these conditions is key to improving patient health outcomes and reducing health care costs. Herein, we review the clinical presentations of these conditions and their underlying pathophysiologic mechanisms.
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- 2021
- Full Text
- View/download PDF
56. Localized Cutaneous Fibrosing Disorders
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David Fiorentino, Kerri E. Rieger, Aaliya Yaqub, and Lorinda Chung
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medicine.medical_specialty ,Pathology ,Graft vs Host Disease ,Disease ,Skin Diseases ,Scleroderma ,Nephrogenic Fibrosing Dermopathy ,Diagnosis, Differential ,Scleroderma, Localized ,Rheumatology ,Scleromyxedema ,Eosinophilia ,medicine ,Humans ,Fasciitis ,Localized Scleroderma ,Scleroderma, Systemic ,Scleredema Adultorum ,integumentary system ,business.industry ,medicine.disease ,Dermatology ,Eosinophilic fasciitis ,Nephrogenic systemic fibrosis ,Chronic Disease ,Scleredema ,Interdisciplinary Communication ,business ,Morphea - Abstract
This article acquaints the reader with disorders of the skin that might mimic systemic sclerosis but whose pathology is localized to the skin and/or has extracutaneous manifestations that are different than systemic sclerosis. These disorders include localized scleroderma (morphea), eosinophilic fasciitis, scleredema, scleromyxedema, nephrogenic systemic fibrosis, and chronic graft-versus-host disease. Particular emphasis is placed on clinical and histopathologic features that help the clinician differentiate between these disorders. Treatment options are briefly reviewed.
- Published
- 2013
57. Scleredema and nodal inflammatory pseudotumor: IgG4-related disease?
- Author
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Ródenas-Herranz T, Mercader-Garcia P, Navarro-Triviño FJ, and Ruiz-Villaverde R
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- Humans, Immunoglobulin G, Plasma Cells, Granuloma, Plasma Cell diagnosis, Immunoglobulin G4-Related Disease complications, Immunoglobulin G4-Related Disease diagnosis, Immunoglobulin G4-Related Disease drug therapy, Scleredema Adultorum
- Published
- 2020
- Full Text
- View/download PDF
58. Laboratory Testing in the Setting of Diabetic Scleredema--Reply
- Author
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Soumya Chatterjee
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Male ,medicine.medical_specialty ,Scleredema Adultorum ,business.industry ,010102 general mathematics ,General Medicine ,Diabetic scleredema ,01 natural sciences ,Laboratory testing ,03 medical and health sciences ,0302 clinical medicine ,Diabetes Mellitus, Type 2 ,Medicine ,Humans ,030212 general & internal medicine ,0101 mathematics ,business ,Intensive care medicine - Published
- 2016
59. Benign lesion on the posterior aspect of the neck
- Author
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Nikoleta, Brankov, Brian, Moore, Kate, Messana, and Melissa, Piliang
- Subjects
Diagnosis, Differential ,Male ,Scleredema Adultorum ,Head and Neck Neoplasms ,Humans ,Collagen ,Fibroma ,Lipoma ,Middle Aged ,Skin - Published
- 2016
60. Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus
- Author
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Lemes, Luciana Rodino, Vilela, Gabriele Medina, Durães, Sandra Maria Barbosa, and Vilar, Enoi Aparecida Guedes
- Subjects
dorsum ,diabetes mellitus ,dorso ,scleredema adultorum ,escleredema do adulto - Abstract
SUMMARY Scleredema of Buschke (SB) is a rare disorder of connective tissue characterized by diffuse non-pitting induration of the skin, mainly on the cervical, deltoid and dorsal regions. It is a cutaneous mucinosis of unknown etiology and is associated with bacterial or viral infections, hematological disorders and diabetes mellitus. Histopathological examination shows thickened dermis with wide collagen bundles separated by gaps that correspond to mucopolysaccharide deposits, visualized using special staining. Several treatments are reported in the literature without well-established results. We report a case of SB in a patient with type 2 diabetes mellitus. RESUMO Escleredema de Buschke (EB) é doença rara do tecido conjuntivo caracterizada por endurecimento difuso e não depressível da pele, principalmente nas regiões cervical, deltoideanas e dorso. Enquadrado no grupo das mucinoses cutâneas, tem etiologia desconhecida e associação com: infecções bacterianas ou virais, alterações hematológicas e diabetes mellitus. O exame histopatológico evidencia derme espessada com fibras colágenas calibrosas separadas por fendas que correspondem a depósito de mucopolissacárides, observados por colorações especiais. Diversos tratamentos são relatados na literatura sem resultados bem definidos. Descrevemos caso de EB em paciente com diabetes mellitus tipo 2.
- Published
- 2016
61. Scleredema of Buschke associated with difficult-to-control type 2 diabetes mellitus
- Author
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Lemes,Luciana Rodino, Vilela,Gabriele Medina, Durães,Sandra Maria Barbosa, and Vilar,Enoi Aparecida Guedes
- Subjects
dorsum ,diabetes mellitus ,scleredema adultorum - Abstract
SUMMARY Scleredema of Buschke (SB) is a rare disorder of connective tissue characterized by diffuse non-pitting induration of the skin, mainly on the cervical, deltoid and dorsal regions. It is a cutaneous mucinosis of unknown etiology and is associated with bacterial or viral infections, hematological disorders and diabetes mellitus. Histopathological examination shows thickened dermis with wide collagen bundles separated by gaps that correspond to mucopolysaccharide deposits, visualized using special staining. Several treatments are reported in the literature without well-established results. We report a case of SB in a patient with type 2 diabetes mellitus.
- Published
- 2016
62. Neck Pain, Stiffness, and Periorbital Edema in a Man With Diabetes
- Author
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Soumya Chatterjee
- Subjects
Male ,medicine.medical_specialty ,Levothyroxine ,Periorbital Edema ,030209 endocrinology & metabolism ,Type 2 diabetes ,Nephropathy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Edema ,Humans ,Neck pain ,Neck Pain ,Scleredema Adultorum ,business.industry ,Headache ,General Medicine ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Surgery ,Diabetes Mellitus, Type 2 ,Headaches ,medicine.symptom ,business ,Neck ,medicine.drug - Abstract
A 61-year-old man with history of hypertension, type 2 diabetes, and hypothyroidism presented for evaluation of neck pain, stiffness, and occipital headaches lasting 4 years. Acetaminophen and meloxicam provided only partial relief. He also noted progressive thickening of skin in the nape of his neck. He denied any prior history of Raynaud phenomenon; heart, kidney, or liver disease; diabetic retinopathy; nephropathy; or neuropathy. He had quit smoking 24 years ago and reported currently drinking 3 glasses of wine per week. His medications included rosiglitazone, glimepiride, and levothyroxine.
- Published
- 2016
63. [Monoclonal immunoglobulin (M-Ig) and skin diseases from the group of mucinoses--scleredema adultorum Buschke and scleromyxedema. Description of four cases and an overview of therapies]
- Author
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Zdeněk, Adam, Petr, Szturz, Marta, Krejčí, Vladimír, Vašků, Luděk, Pour, Eva, Michalková, Sabina, Ševčíková, Zdeňka, Čermáková, Karel, Veselý, Jíří, Vaníček, Eva, Pourová, Zdeněk, Král, and Jiří, Mayer
- Subjects
Male ,Scleredema Adultorum ,Immunoglobulin G ,Scleromyxedema ,Humans ,Immunoglobulins, Intravenous ,Immunologic Factors ,Female ,Middle Aged ,Aged - Abstract
The mucinoses of the type of scleredema and scleromyxedema are diseases marked by excessive production of mucin deposits in the skin and subcutaneous tissue, which causes skin hardening. The skin and subcutaneous deposits hamper the movement of limbs, the thorax as well as mouth. The same mechanism also damages other organs (the heart, lungs, oesophagus). It is probably caused by the stimulation of mucin production in fibroblasts by immunoglobulins, frequently monoclonal immunoglobulin. Therefore these diseases are typically associated with monoclonal gammopathy.We describe a cohort of 4 patients, skin manifestations were twice identified as scleredema and twice as scleromyxedema. All the four patients had type IgG monoclonal immunoglobulin and had clonal plasma cells in the bone marrow proven by histologic examination and flow cytometry. Therefore we commenced chemotherapy in all of them. In one case this chemotherapy was ended by a high-dose chemotherapy with transplanting of autologous red blood cells. This therapy attained the complete disappearance of monoclonal immunoglobulin as well as cutaneous and extracutaneous manifestations of scleredema (obstipation). In one case chemotherapy led to partial hematologic remission and partial improvement of skin manifestations. The other two patients did not respond to standard chemotherapy. The condition of one of them resulted in dermato-neuro syndrome (confusion, somnolence passing into coma and grand mal seizure) and improved following an intensive treatment including also intravenous application of immunoglobulins in a dose of 2 g/per 1 kg weight. This patient has now been under long-term treatment with these immunoglobulins, during which the skin symptoms have significantly diminished, but the concentration of monoclonal immunoglobulin has not changed. The fourth patient not responding to standard chemotherapy was treated with intravenous immunoglobulins also in a dose of 2 g/per 1 kg of weight 1× in a month. After 4 applications the thickening of skin and subcutaneous tissue moderately diminished, so the range of possible movement of the upper limbs and neck became larger and the itchy skin morphs which accompanied the disease disappeared completely.It is possible to use chemotherapy and high-dose chemotherapy in the treatment of mucinosis associated with monoclonal gammopathy, as in the treatment of multiple myeloma. If such treatment is not possible or it has not attained disappearance of monoclonal immunoglobulin, improvement can be achieved through repeated application of intravenous immunoglobulins. The treatment with intravenous immunoglobulins in an immunomodulation dose of 2 g/per 1 kg of weight effects the moderation of skin manifestations, but it does not lead to the decrease in monoclonal immunoglobulin.
- Published
- 2016
64. Juvenile Scleredema of Buschke
- Author
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Sheeba Gupta, Ajit V Koshy, Suneel G Patil, J Dhanuja Rani, S T Srinivas Murthy, and Deepak Nagpal
- Subjects
medicine.medical_specialty ,Facial Muscles ,Uncommon disorder ,Muscular Diseases ,Skin Physiological Phenomena ,Antibiotic therapy ,medicine ,Humans ,Clinical significance ,Child ,General Dentistry ,Scleredema Adultorum ,business.industry ,medicine.disease ,Dermatology ,Trunk ,Elasticity ,Anti-Bacterial Agents ,Surgery ,Facial muscles ,medicine.anatomical_structure ,Scleredema ,Female ,Good prognosis ,business ,Reticular Dermis ,Facial Dermatoses ,Follow-Up Studies - Abstract
Aim To recognize a line of treatment for scleredema of Buschke in an adolescent. Background Scleredema of Buschke is an uncommon disorder characterized by induration of the skin, which includes a non pitting hardening of the skin around the neck, shoulders, and trunk sometimes the face. Three variants are recognized. The histopathologic features of scleredema are characterized by thickened collagen bundles within the reticular dermis that are separated by mucin containing fenestrations. No consistent treatment modality is currently followed. Case report The present case report describes scleredema of Buschke in a 10-year-old female child reported with stiffness of facial skin and difficulty in opening the mouth. The patient was treated with antibiotics and vitamin supplements and there was drastic improvement with decrease in skin stiffness and increase in mouth opening. The stiffness of facial muscles decreased and mouth opening increased. Conclusion Multiple treatment modalities for scleredema have been used. In the present case, high-dose antibiotic therapy was used with good prognosis. Clinical significance High-dose antibiotic therapy can be used for treatment of dermatologic disorders with reasonably good prognosis. How to cite this article Rani JD, Patil SG, Murthy STS, Koshy AV, Nagpal D, Gupta S. Juvenile Scleredema of Buschke. J Contemp Dent Pract 2012;13(1):111-114.
- Published
- 2012
65. Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients
- Author
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Valentina Fausti, Eduardo Calonje, Catherine M. Stefanato, Franco Rongioletti, Bernard Cribier, Jean Kanitakis, Dieter Metze, Giulia Merlo, Elisa Cinotti, Eduardo Marinho, Emanuele Cozzani, Werner Kempf, Aurora Parodi, University of Zurich, Rongioletti, F, Kaiser, F, Cinotti, E, Metze, D, Battistella, M, Calzavara-Pinton, Pg, Damevska, K, Girolomoni, G, André, J, Perrot, Jl, Kempf, W, and Cavelier-Balloy, B
- Subjects
Male ,Survival rate ,Pediatrics ,PUVA therapy ,Paraproteinemias ,Disease ,Comorbidity ,Adrenal Cortex Hormones ,Scleredema adultorum ,Scleromyxedema ,Medicine ,Young adult ,Middle aged ,Prospective cohort study ,Scleredema Adultorum ,10177 Dermatology Clinic ,Middle Aged ,Survival Rate ,Infectious Diseases ,Infectious diseases ,Female ,Immunosuppressive agents ,Type 2 ,Immunosuppressive Agents ,Adult ,medicine.medical_specialty ,610 Medicine & health ,Dermatology ,2708 Dermatology ,Young Adult ,Diabetes Mellitus ,Humans ,Obesity ,Diabetes mellitus Type 2 ,PUVA Therapy ,Aged ,Dyslipidemias ,Retrospective Studies ,business.industry ,Adrenal cortex hormones ,Retrospective cohort study ,2725 Infectious Diseases ,medicine.disease ,Surgery ,Retrospective studies ,Diabetes Mellitus, Type 2 ,Scleredema ,business - Abstract
Background Scleromyxedema is associated with a monoclonal gammopathy and other comorbidities. Its prognostic and therapeutic features are poorly documented because most reports deal with single cases or small series. Objective We sought to describe the characteristics of patients with scleromyxedema regarding demographics, clinical characteristics, comorbidities, therapeutic interventions, and course. Methods We conducted a retrospective and prospective multicenter study. Results We identified 30 patients with scleromyxedema (17 men and 13 women). The mean age at diagnosis was 59 years. The mean delay between disease onset and diagnosis was 9 months. Monoclonal gammopathy was detected in 27 patients. Extracutaneous manifestations were present in 19 patients including neurologic (30%), rheumatologic (23.3%), and cardiac (20%) manifestations. Two patients developed hematologic malignancies. The most common therapies included oral steroids and intravenous immunoglobulins. Although corticosteroids were ineffective, intravenous immunoglobulins (alone or in combination with other drugs) induced complete remission in 4 and partial remission in 9 patients with a mean treatment duration of 2 years. In all, 21 patients were followed up for a mean period of 33.5 months, at which time 16 patients were alive, 12 with and 4 without skin disease. Five patients died: 2 with dermatoneuro syndrome and 1 each with myeloid leukemia, Hodgkin lymphoma, and myocardial insufficiency. Limitations This is mainly a retrospective study. Conclusions Our study confirms that scleromyxedema is a chronic and unpredictable disease with severe systemic manifestations leading to a guarded prognosis. There is no specific definitive treatment. Our data support the contention that intravenous immunoglobulin is a relatively effective and safe treatment. The response is not permanent and maintenance infusions are required.
- Published
- 2015
66. Scleroderma Mimics
- Author
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Virginia D. Steen and Jennifer Nashel
- Subjects
medicine.medical_specialty ,Scleredema Adultorum ,integumentary system ,business.industry ,medicine.disease ,Diabetic cheiroarthropathy ,Dermatology ,Scleroderma ,Eosinophilic fasciitis ,Nephrogenic Fibrosing Dermopathy ,Diagnosis, Differential ,Scleroderma, Localized ,Rheumatology ,Scleromyxedema ,Nephrogenic systemic fibrosis ,Eosinophilia ,Scleredema ,Humans ,Medicine ,Fasciitis ,skin and connective tissue diseases ,business ,Localized Scleroderma ,Morphea - Abstract
Scleroderma is a rare systemic autoimmune disease with multiple organ manifestations, including skin fibrosis. The groups of disorders classified as scleroderma mimics share the common thread of skin thickening but are otherwise quite incongruous in terms of underlying disease process and other organ involvement. This article reviews the clinical presentation, etiology, and treatment options available for scleroderma mimics, including morphea, scleredema, diabetic cheiroarthropathy, scleromyxedema, nephrogenic systemic fibrosis, and eosinophilic fasciitis. Through greater understanding of these diseases and the associated extradermal implications, we hope to facilitate recognition of scleroderma and its mimics.
- Published
- 2011
67. Buschke Scleredema, case report
- Author
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P. Gangemi, Rosario Foti, C. Leonetti, R. De Pasquale, R. Leonardi, M. Di Gangi, and G. Fichera
- Subjects
Male ,Connective Tissue Disorder ,medicine.medical_specialty ,Pathology ,lcsh:Internal medicine ,Biopsy ,Limbs movements ,lcsh:Medicine ,Dyscrasia ,Diagnosis, Differential ,Rheumatology ,Dermis ,Adrenal Cortex Hormones ,Humans ,Medicine ,lcsh:RC31-1245 ,Aged ,Skin ,Scleredema Adultorum ,business.industry ,lcsh:R ,medicine.disease ,Dermatology ,Tubulin Modulators ,Eosinophilic fasciitis ,Treatment Outcome ,medicine.anatomical_structure ,Scleredema ,Drug Therapy, Combination ,Skin Induration ,Differential diagnosis ,Colchicine ,business - Abstract
Buschke Scleredema is a rare connective tissue disorder of unknown aetiology, characterized by thickening of the dermis whose characteristics may mainly to mime systemic sclerosis, eosinophilic fasciitis and cutaneous amyloidosis. Scleredema may be associated with a history of an antecedent febrile illness, diabetes mellitus, or blood dyscrasia. Scleredema can be classified into three clinical groups; each has a different history, course, and prognosis. Each one of these share reduction in chest articular movements and limitation of limbs movements. The skin histology is characterised by thickened dermis and increased spaces between large collagen bundles due to increased deposition of mucopolysaccharide in the dermis. Differential diagnosis can be made considering the typical clinical features and the histologic peculiarity. No therapy has been found effective. The authors describe a case of Buschke Scleredema successfully treated by steroids and colchicine. Clinical evaluation of skin induration and thickness as well as ultrasonography were performed at baseline and after treatment.
- Published
- 2011
68. Scleroedema of Buschke in conjunction with ovarian carcinoma: rare association of a rare disease.
- Author
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Dev N, Kumar R, Sharma S, Mahto K, and Kumawat A
- Subjects
- Biopsy, Female, Humans, Middle Aged, Rare Diseases, Skin, Ovarian Neoplasms complications, Scleredema Adultorum
- Abstract
Scleroedema is a rare clinical condition characterised by diffuse woody induration of skin commonly associated with diabetes mellitus, infections and monoclonal gammopathy. Its association with ovarian malignancy has not been reported. We report a case of a 56-year-old female with rapidly progressing skin thickening of limbs, face and trunk for 1 year and abdominal distension for 3 months. Patient had thickened skin, mask-like facies and ascites on examination. Atypical cells were seen in ascitic fluid. Contrast-enhanced computerised axial tomography scan of abdomen was suggestive of ovarian malignancy. Markers for autoimmune disorders were negative. CA 125 was elevated. Other causes of sclerodermiform-like syndrome were ruled out. Histopathology of skin biopsy was definitive of scleroedema. Diagnosis of scleroedema associated with ovarian malignancy was made based on temporal association, exclusion of other causes and histopathological findings. To our knowledge this is the first reported case of scleroedema associated with ovarian tumour., Competing Interests: No conflict of interests declared
- Published
- 2020
- Full Text
- View/download PDF
69. European Guidelines on Cardiovascular Disease Prevention in Clinical Practice: CEIPC 2008 Spanish adaptation
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V. Lizarbe, M.A. Vargas, Emilio Luengo, Alfonso del Río, Luis A. Álvarez-Sala, Fernando Jesús Antoñanzas Villar, Mercedes Martínez, José M. Lobos, Ángel Lizcano, A. Maiques, D. Mauricio, Miguel Ángel Royo-Bordonada, Carlos Brotons, Pedro Conthe, Ana de Santiago, A. Gil-Núñez, Olga Cortés, Susana Sans, Fernando de Alvaro, and Pedro Armario
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Riesgo cardiovascular ,Waist ,MEDLINE ,Primary care ,Type 2 diabetes ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Prevención cardiovascular ,Pharmacology (medical) ,Exercise ,Aged ,Medicine(all) ,Scleredema Adultorum ,business.industry ,Smoking ,Public Health, Environmental and Occupational Health ,Age Factors ,General Medicine ,Middle Aged ,Cardiovascular risk ,medicine.disease ,Artículo especial ,Surgery ,Diet ,Europe ,Cardiovascular prevention ,Cholesterol ,Blood pressure ,Cardiovascular Diseases ,Spain ,Practice Guidelines as Topic ,Female ,Disease prevention ,Enfermedades cardiovasculares ,Metabolic syndrome ,Family Practice ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Kidney disease - Abstract
ResumenPresentamos la adaptación española realizada por el Comité Español Interdisciplinario para la Prevención Cardiovascular (CEIPC) de la Guía Europea de Prevención de las Enfermedades Cardiovasculares 2008. Esta guía recomienda el modelo SCORE de riesgo bajo para valorar el riesgo cardiovascular. El objetivo es prevenir la mortalidad y la morbilidad debidas a las enfermedades cardiovasculares (ECV) mediante el tratamiento de sus factores de riesgo en la práctica clínica. La guía hace énfasis en la prevención primaria y en el papel del médico y el personal de enfermería de atención primaria en la promoción de un estilo de vida cardiosaludable, basado en el incremento de los grados de actividad física, la adopción de una alimentación saludable y, en los fumadores, el abandono del tabaco. La meta terapéutica para la presión arterial es en general
- Published
- 2009
70. Scleredema Diabeticorum - A Case Report
- Author
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M N, Shazzad, A K, Azad, S J, Abdal, R, Afrose, M M, Rahman, and S A, Haq
- Subjects
Diagnosis, Differential ,Male ,Methotrexate ,Diabetes Mellitus, Type 2 ,Scleredema Adultorum ,Humans ,Dermatologic Agents ,Middle Aged ,Combined Modality Therapy ,PUVA Therapy - Abstract
Buschke Scleredema is a rare connective tissue disorder of unknown aetiology and characterized by thickening of the dermis. It resembles systemic sclerosis, eosinophilic fasciitis and cutaneous amyloidosis. Scleredema may be associated with a history of an antecedent febrile illness, diabetes mellitus, or blood dyscrasia. It may be classified into three clinical groups, each has a different history, course, and prognosis. Histology of skin is characterized by thickened dermis and increased spaces between large collagen bundles due to increased deposition of mucopolysaccharide in the dermis. Differential diagnosis can be made considering the typical clinical features and the histological peculiarity. No therapy is effective. In this communication we have presented a 54 year old man with scleredema successfully treated by PUVA and methotrexate. We reviewed associated diseases, clinical and histopathological characteristics, evolution and response to treatment.
- Published
- 2015
71. Scleredema associated with Sjögren’s syndrome
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Alves, João, Judas, Tiago, Ferreira, Tiago, Matos, Diogo, and Bártolo, Elvira
- Subjects
Mucinoses ,Autoimmune diseases ,Scleredema adultorum - Abstract
Scleredema adultorum of Buschke is a rare disorder characterized by diffuse swelling and non-pitting induration of the skin usually involving the face, neck, arms and upper trunk. It has been associated with previous infectious diseases, diabetes, paraproteinemia and, more rarely, malignant neoplasms or autoimmune disorders. We report the case of a 30-year-old man who presented with a 2-year history of scleredema. Further investigation led to the diagnosis of primary Sjögren’s syndrome. The association between scleredema and autoimmune disorders has been rarely seen. To our knowledge, there are no other reports describing the association between primary Sjögren’s syndrome and scleredema adultorum of Buschke.
- Published
- 2015
72. Scleredema Adultorum of Buschke
- Author
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Joana Castro, Carvalho, Thaís Neves, Costa, Heloisa Helena Gonçalves, De Moura, Leonardo Pereira, Quintella, Sueli, Carneiro, and Marcia, Ramos-e-Silva
- Subjects
Male ,Scleredema Adultorum ,Disease Progression ,Humans ,Middle Aged ,Skin - Published
- 2015
73. Scleredema adultorum of Buschke with prominent periorbital edema in a Tunisian patient with diabetes mellitus: a case report
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Jameleddine Zili, Adnène Moussa, Hichem Belhadjali, Mariem Mohamed, and Amel Belhaj Béchir
- Subjects
Adult ,Male ,medicine.medical_specialty ,Periorbital Edema ,02 engineering and technology ,Dermatology ,Diabetes Complications ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Edema ,Diabetes mellitus ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Diabetes Mellitus ,Eyelid Diseases ,Humans ,Scleredema Adultorum ,business.industry ,020208 electrical & electronic engineering ,medicine.disease ,Surgery ,Scleredema ,medicine.symptom ,business - Published
- 2015
74. Scleredema adultorum of Buschke: an under recognized skin complication of diabetes
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P Jacquet, C. Meguerditchian, René Valéro, Bernard Vialettes, Sophie Béliard, T Benderitter, and F Carsuzza
- Subjects
Adult ,Male ,Systemic disease ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Skin Diseases ,Diabetes Complications ,Endocrinology ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Respiratory function ,Scleredema Adultorum ,business.industry ,Microangiopathy ,General Medicine ,medicine.disease ,Connective tissue disease ,Dermatology ,Surgery ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Scleredema ,business ,Complication - Abstract
Summary Scleredema of Buschke or scleredema diabetorum is a skin complication of diabetes with deposits of collagen and aminoglycans in the dermis. This disease characterized by thickening and hardening of the skin, is usually localized in nape, back and shoulder areas. Consequences could be a decrease in motility of the shoulders and an impairment of respiratory function. Other possible complications are sleep apnoea syndrome and monoclonal gammapathy. Type 1 or type 2 diabetes may be associated with scleredema of Buschke in more than 50% of cases. Diabetes-related risk factors are long duration of the disease, presence of microangiopathy, overweight and need of insulin. Various specific treatments proposed in the literature are poorly validated. In most severe cases, radiation therapy may be useful.
- Published
- 2006
75. UVA1 phototherapy for cutaneous diseases: an experience of 92 cases in the United States
- Author
-
Henry W. Lim, Charles R. Taylor, Heidi Jacobe, Chanisada Tuchinda, Craig A. Elmets, Bettany M. Bergamo, Jennifer Rivard, and Holly Kerr
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Erythema ,Immunology ,Hand Dermatoses ,Dermatology ,Severity of Illness Index ,Skin Diseases ,Medical Records ,Dermatitis, Atopic ,Urticaria Pigmentosa ,Severity of illness ,Humans ,Immunology and Allergy ,Medicine ,Radiology, Nuclear Medicine and imaging ,Child ,Adverse effect ,Aged ,Retrospective Studies ,Foot Dermatoses ,Scleredema Adultorum ,business.industry ,Medical record ,General Medicine ,Atopic dermatitis ,Middle Aged ,medicine.disease ,United States ,Treatment Outcome ,Child, Preschool ,Scleredema ,Urticaria pigmentosa ,Female ,Ultraviolet Therapy ,medicine.symptom ,business ,Morphea - Abstract
Background: The efficacy and safety of UVA1 (340–400 nm) phototherapy were established by studies from European countries. Purpose: Evaluate experience with UVA1 phototherapy for patients with cutaneous diseases in the United States. Methods: A retrospective analysis of 92 cases of UVA1-treated cutaneous conditions from four medical centers in the United States was performed. Results: Two-third of the patients showed a fair to good response (26–100% improvement) and one-third of the patients showed a poor response (0–25% improvement). Diseases with a moderate to good response (51–100% improvement) included scleredema adultorum, hand or foot dermatitis, atopic dermatitis, morphea (medium or medium- to high-dose UVA1), systemic sclerosis, and urticaria pigmentosa. Besides tanning, other adverse effects were found in 15% of patients, which include pruritus, erythema, tenderness, and burning sensation. Patients with skin types I–III responded better that those with a darker skin type. Conclusion: UVA1 phototherapy is a useful and well-tolerated treatment option for a variety of skin conditions.
- Published
- 2006
76. Scleredema Adultorum of Buschke: A Case Report and Review of the Literature
- Author
-
William H. Beers, A Ince, and Terry L. Moore
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Biopsy ,English language ,Disease ,Rheumatology ,Hypergammaglobulinemia ,hemic and lymphatic diseases ,medicine ,Humans ,B-cell lymphoma ,Multiple myeloma ,Skin ,Skin Findings ,Scleredema Adultorum ,medicine.diagnostic_test ,business.industry ,Bone Marrow Examination ,Blood Protein Electrophoresis ,medicine.disease ,Dermatology ,Bone marrow examination ,Anesthesiology and Pain Medicine ,Scleredema ,business - Abstract
Objectives To present a case of scleredema adultorum of Buschke associated with hypergammaglobulinemia and review the literature pertaining to this disease. Methods Search of MEDLINE (PubMed) was performed using the words "Scleredema Adultorum." Only cases in the English language, with pertinent clinical information for analysis, were included. Results We present a case of scleredema associated with hypergammaglobulinemia. The skin findings had been progressive for 2 years before he was diagnosed with scleredema. Our patient was found to have a B-cell lymphoma before being diagnosed with scleredema. The progression of skin thickening halted with no apparent correlation to immunosuppressive therapies or chemotherapeutic agents. A total of 165 cases of scleredema adultorum are described in the literature. There are 3 types of scleredema adultorum. Type 1 is usually preceded by a febrile episode and resolves spontaneously. Type 2 is associated with developing paraproteinemias including multiple myeloma. Type 3 is associated with diabetes mellitus. Conclusions Scleredema adultorum of Buschke is a rare disorder which is sometimes associated with hypergammaglobulinemia; our patient had a B-cell lymphoma. Physicians should suspect scleredema in any patient with diffuse skin thickening where the hands and feet are spared, particularly if diabetes or a preceding febrile episode were present. Once the diagnosis of scleredema is made, evidence for the presence of hypergammaglobulinemia should be sought.
- Published
- 2006
77. From scleredema to AL amyloidosis: disease progression or coincidence? Review of the literature
- Author
-
Armando Gabrielli, Philip N. Hawkins, Christopher P. Denton, Geraldine Brough, Carol M. Black, Constantinos P. Anastassiades, Michael N. Potter, and Magdalena Dziadzio
- Subjects
Paraproteinemia ,Pathology ,medicine.medical_specialty ,Scleredema Adultorum ,business.industry ,Amyloidosis ,Paraproteinemias ,General Medicine ,Middle Aged ,medicine.disease ,Dyscrasia ,Scleroderma ,Rheumatology ,hemic and lymphatic diseases ,Disease Progression ,medicine ,AL amyloidosis ,Scleredema ,Humans ,Female ,Differential diagnosis ,Multiple Myeloma ,business ,Multiple myeloma - Abstract
Scleredema (also called scleredema of Buschke) is a fibromucinous connective tissue disorder of unknown cause that belongs to a group of scleroderma-like disorders. We report the case of a 64-year-old lady with long-standing scleredema, associated with a paraprotein, and progressing to multiple myeloma and AL amyloidosis. The relationship of scleredema with paraprotein and multiple myeloma is well established, but only two cases of scleredema associated with amyloidosis have been reported to date. We suggest that amyloidosis may be underdiagnosed in patients with scleredema and paraproteinaemia. Features attributed to extracutaneous manifestations of scleredema could represent systemic amyloidosis. We review published reports of scleredema associated with paraprotein and discuss the difficulties in the differential diagnosis of scleroderma-like disorders. We discuss the diagnosis of plasma cell dyscrasias and amyloidosis and their relevance in rheumatology practice.
- Published
- 2005
78. Scleredema adultorum of Buschke presenting as periorbital edema: A diagnostic challenge
- Author
-
John G Panayiotidis, Maria Stefanidou, Konstantin Krasagakis, Spyros Karampekios, Androniki D. Tosca, and Despina I. Ioannidou
- Subjects
Male ,Systemic disease ,Paraproteinemia ,Pathology ,medicine.medical_specialty ,Scleredema Adultorum ,business.industry ,Periorbital Edema ,Dermis ,Dermatology ,Middle Aged ,medicine.disease ,Connective tissue disease ,Asymptomatic ,Edema ,Eyelid Diseases ,Scleredema ,Humans ,Medicine ,Collagen ,medicine.symptom ,business ,Multiple myeloma - Abstract
Scleredema adultorum is a rare sclerotic disorder characterized by diffuse swelling and nonpitting induration of the skin. Its occurrence has been documented in association with infections, diabetes mellitus, paraproteinemia, multiple myeloma, and monoclonal gammopathy. We report an unusual case of a 48-year-old man with an asymptomatic bilateral eyelid edema of sudden onset. During a period of 6 months, the condition slowly progressed to extensive nonpitting edematous swelling restricted to the periorbital sites. The presumptive diagnosis of scleredema adultorum was confirmed by the presence of typical histologic findings. This case is unique in that the periorbital swelling remained as the sole clinical manifestation of scleredema during the 5-year follow-up and was complicated with partial vision blockage.
- Published
- 2005
79. Radiotherapy of Benign Diseases—Scleredema Adultorum Buschke
- Author
-
Oliver Micke, Stefan Könemann, Stephan Grabbe, Andreas Schuck, Stefan Hesselmann, Daniela De Simoni, Tobias Bölling, Normann Willich, and Christos Moustakis
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Disease ,Pathogenesis ,Upper trunk ,Diabetes mellitus ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Practice Patterns, Physicians' ,Scleredema Adultorum ,business.industry ,Middle Aged ,medicine.disease ,Dermatology ,Surgery ,Radiation therapy ,Treatment Outcome ,medicine.anatomical_structure ,Oncology ,Practice Guidelines as Topic ,Etiology ,Scleredema ,Radiotherapy, Conformal ,business ,Progressive disease - Abstract
Scleredema adultorum Buschke is a rare disorder characterized by thickening of the dermis of the neck, head and upper trunk. Its etiology is unknown, but there may be a preceding history of infection and there is a known association with diabetes mellitus. Women are more frequently affected. Usually, the disease is self-limiting but some patients show progressive disease. In these cases therapeutic options are poor, with only case reports and small series supporting their use.A 58-year-old patient with a scleredema of the neck and upper trunk is described, who was treated twice within 6 months by electron-beam radiation therapy. After the second course his symptoms improved significantly. A review of the literature of radiation treatment of this disease is given.. Regardless of the possible mechanisms in pathogenesis and treatment of scleredema adultorum Buschke, the application of ionizing radiation is an important, effective and well-tolerated therapy option in the treatment of severe cases and may candidate as the first-line treatment of this disease.
- Published
- 2004
80. Two Cases for Diagnosis: Asymmetric Childhood Scleredema or Stiff Skin Syndrome?
- Author
-
Nancy B. Esterly, Eric Challgren, Anita Nijhawan, Judyann C. Olson, Charles H. Spencer, Maria Medenica, Dean S. Morrell, and T. Anne Laumann
- Subjects
musculoskeletal diseases ,Systemic disease ,Pathology ,medicine.medical_specialty ,animal structures ,Diagnostico diferencial ,macromolecular substances ,Dermatology ,Diagnosis, Differential ,medicine ,Humans ,Child ,Scleroderma, Systemic ,Scleredema Adultorum ,integumentary system ,business.industry ,Syndrome ,equipment and supplies ,medicine.disease ,Key features ,Connective tissue disease ,Stiff skin syndrome ,Pediatrics, Perinatology and Child Health ,Scleredema ,Female ,business - Abstract
Two children with chronic and asymmetric skin indurations are presented. The clinical and pathologic features are suggestive of asymmetric childhood scleredema and stiff skin syndrome. The key features of scleredema and stiff skin syndrome are discussed.
- Published
- 2003
81. [Scleredema adultorum Buschke and exulcerated necrobiosis lipoidica in diabetes mellitus type 1]
- Author
-
A-K, Dumke, J, Tittelbach, and P, Elsner
- Subjects
Diagnosis, Differential ,Diabetes Mellitus, Type 1 ,Necrobiosis Lipoidica ,Scleredema Adultorum ,Biopsy ,Disease Progression ,Humans ,Female ,Leg Dermatoses ,Middle Aged ,Combined Modality Therapy ,Skin - Abstract
A 53-year-old woman suffering from brown plaques occasionally ulcerating at both lower legs and in the course of disease on the back of the foot presented at our department. Moreover she complained about an increasing sclerosis of her skin at the back over the last 15 years. She had suffered from diabetes mellitus type-1 for more than 40 years.Skin biopsies form the ulcerated plaques showed changes typical for necrobiosis lipoidica. Biopsies of the back were diagnosed as scleredema adultorum Buschke. Laboratory tests displayed a normal antinuclear antibody titer. The differential diagnosis of systemic sclerosis could be ruled out.We repeatedly performed debridement of ulcers, cream-PUVA therapy, applied a vacuum-sealing and topical corticosteroids at the lower legs. Meanwhile she received oral pentoxyfillin. The scleredema was treated with UVA-1 phototherapy but had to be stopped for high photosensitivity. Additionally physiotherapy was prescribed. Nonetheless the course of disease was chronic and therapy-resistant.Skin diseases are common in diabetes mellitus. Necrobiosis lipoidica and scleredema adultorum Buschke are rare complications but often refractory to treatment.
- Published
- 2014
82. Scleredema diabeticorum
- Author
-
Kathleen, Tran, Kevin P, Boyd, Maria R, Robinson, and Michael, Whitlow
- Subjects
Diabetes Complications ,Male ,Scleredema Adultorum ,Face ,Diabetes Mellitus ,Humans ,Middle Aged ,Skin - Abstract
We present a case of scleredema with a leonine facies in a 56-year-old man with a history of poorly controlled diabetes mellitus. The patient initially presented with erythematous, edematous papules and plaques on the face, neck, and upper back.
- Published
- 2013
83. Cutaneous indurated plaque on the abdomen associated with diabetes mellitus
- Author
-
Maria, Salazar-Nievas, Vicente, Crespo-Lora, Juan, Rubio-López, and Salvador, Arias-Santiago
- Subjects
Diabetes Complications ,Diagnosis, Differential ,Scleredema Adultorum ,Humans ,Female ,Aged - Abstract
A woman, 74 years of age, presented to the emergency department with a lesion on the lower abdominal wall that had started a month earlier and was not associated with any other symptoms. Her family physician had treated it with emollient creams. Relevant past medical history included congestive heart failure, hypertension, hypertensive heart disease, pulmonary hypertension, mitral regurgitation, chronic atrial fibrillation, rosacea and diabetes mellitus that was being treated with oral hypoglycaemics (metformin). Physical examination revealed an area of skin on the lower abdominal wall that was ill-defined and indurated, with whitish papules and a 'cobblestone' appearance (Figure 1).
- Published
- 2013
84. Scleroedema diabeticorum: Erfolgreiche Behandlung mit UV-A1-Phototherapie
- Author
-
Kochs, C., Bockmann, A., Hanneken, S., and Neumann, N.J.
- Published
- 2011
- Full Text
- View/download PDF
85. [Sclerosing skin diseases].
- Author
-
Sticherling M
- Subjects
- Humans, Sclerosis, Skin Diseases pathology, Eosinophilia pathology, Fasciitis pathology, Nephrogenic Fibrosing Dermopathy pathology, Scleredema Adultorum pathology, Scleroderma, Localized pathology, Scleroderma, Systemic pathology, Scleromyxedema pathology, Skin Diseases complications
- Abstract
Sclerosing skin manifestations are more a symptom than a diagnosis and must therefore be meticulously clarified. Systemic scleroderma as a multiorgan disease must be distinguished from localized scleroderma or morphea because in addition to a different clinical picture they have a different prognosis and necessitate other therapeutic procedures. Rare sclerosing skin diseases with implications for internal medicine are eosinophilic fasciitis, Buschke's scleredema adultorum, scleromyxedema and nephrogenic systemic fibrosis.
- Published
- 2019
- Full Text
- View/download PDF
86. [A case report of foot wounds repair in patient with systemic sclerosis].
- Author
-
Li JJ, Yang KY, Zhu B, Wang KJ, Zhang J, Huang J, Zhu F, and Wang X
- Subjects
- Humans, Skin, Foot Diseases etiology, Scleredema Adultorum, Scleroderma, Systemic complications
- Abstract
Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© 2019 by the China Journal of Orthopaedics and Traumatology Press.)
- Published
- 2019
- Full Text
- View/download PDF
87. In vivo study of skin mechanical properties in scleredema of Buschke
- Author
-
Hristo Dobrev
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Time Factors ,Dermatology ,Distension ,Reference Values ,In vivo ,Quantitative assessment ,medicine ,Humans ,Elasticity (economics) ,Skin ,Scleredema Adultorum ,integumentary system ,business.industry ,Healthy subjects ,Mean age ,General Medicine ,Middle Aged ,medicine.disease ,Elasticity ,Scleredema ,Female ,Skin Induration ,business - Abstract
A non-invasive, in vivo suction device was used to investigate the mechanical properties of the skin in a patient with scleredema of Buschke. Clinical scoring of skin induration and measurements of skin elasticity were performed over 9 anatomic regions on admission and after 3 (on discharge), 17 and 28 months. Immediate distension, final distension and immediate retraction were significantly decreased, while the viscoelastic to elastic ratio was significantly increased in the patient as compared to the healthy controls. Delayed distension and biological elasticity were preserved. Low values of skin distensibility correlated with a severe skin induration (p0.001). The changes were more expressive with the 8 mm-diameter measuring probe than the 2 mm-diameter probe. The method applied can be used for objective and quantitative assessment of skin involvement in scleredema of Buschke.
- Published
- 1998
88. Diabetic Scleredema: A Case Report and Biochemical Analysis for Glycosaminoglycans
- Author
-
Tomoo Watanabe, Takashi Kobayashi, and Yuichiro Yamasaki
- Subjects
medicine.medical_specialty ,Mucinoses ,Dermatan Sulfate ,Dermatology ,Diabetic scleredema ,Diabetes Complications ,Glycosaminoglycan ,chemistry.chemical_compound ,Dermis ,Fibrosis ,Hyaluronic acid ,medicine ,Humans ,Hyaluronic Acid ,Glycosaminoglycans ,Skin ,Scleredema Adultorum ,integumentary system ,business.industry ,Chondroitin Sulfates ,Mucin ,Mucins ,General Medicine ,Middle Aged ,medicine.disease ,Mucinosis ,medicine.anatomical_structure ,chemistry ,Female ,Thickening ,business - Abstract
We report a patient with the typical lesions of diabetic scleredema. Histological findings of the involved skin were thickening of the dermis, depositions of mucins, and fibrosis. Biochemical analysis revealed an increase in glycosaminoglycans in the involved skin as well as in the cutaneous lupus mucinosis. Mucinous materials were composed of hyaluronic acid.
- Published
- 1997
89. Acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: A case report
- Author
-
Anna Krishtul, Mei-Heng Tan, Mark Lebwohl, and Sumedha Lamba
- Subjects
Male ,Systemic disease ,medicine.medical_specialty ,Scleredema Adultorum ,business.industry ,Hyperkeratosis ,Dermatology ,medicine.disease ,Connective tissue disease ,Dyskeratosis ,Diabetes Mellitus, Type 1 ,Diabetes mellitus ,medicine ,Scleredema ,Humans ,Acanthosis Nigricans ,business ,Acanthosis nigricans ,Pigmentation disorder ,Aged - Abstract
Acanthosis nigricans (AN) and scleredema are two skin conditions that have been reported in association with diabetes mellitus. Few cases associating scleredema and AN have been reported. A literature search did not reveal any reports of diabetic patients developing AN on top of a scleredema plaque. Here we report a patient with diabetes mellitus who developed AN within the same indurated scleredema plaque.
- Published
- 2005
90. Reconstitution of skin fibrosis development using a tissue engineering approach
- Author
-
Véronique J, Moulin
- Subjects
Cryopreservation ,Keratinocytes ,Scleroderma, Systemic ,Cicatrix, Hypertrophic ,Scleredema Adultorum ,Tissue Engineering ,Cell Culture Techniques ,Cell Separation ,Fibroblasts ,Fibrosis ,Skin Diseases ,Scleroderma, Localized ,Humans ,Cells, Cultured ,Skin - Abstract
Skin fibrosis is involved in several pathologies as hypertrophic scar or scleroderma. The determination of the mechanisms at the origin of these problems is however difficult due to the low number of in vivo models. To bypass this absence of animal models, studies typically use human pathological cells cultured in a monolayer way on plastic. However, cell behavior is different according to the fact that cells are on plastic or embedded in matrix. Using a tissue engineering method, we have developed new in vitro models to study these pathologies of the skin. Human pathological cells are used to reconstitute a three dimensional fibrotic tissue comprising the dermal and the epidermal parts of the skin. This method is called the self-assembly approach and is based on the cell capacity to reconstitute in vitro their own environment as in vivo. In this chapter, protocols generating reconstructed pathological skin using this approach are detailed. The methods include extraction and culture of human skin keratinocytes and fibroblasts from very small cutaneous biopsies. In addition, a description of the protocols for the production of fibrotic dermal sheets can be found to obtain a model of fibrotic dermis that can be associated or not with a fully differentiated epidermis.
- Published
- 2013
91. SKIN AND DIABETES
- Author
-
Sandra J. Landolt, R. Gary Sibbald, and Darryl Toth
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Controlled studies ,Skin Diseases ,Necrobiosis lipoidica ,Diabetes Complications ,Granuloma Annulare ,Blister ,Endocrinology ,Insulin resistance ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,Humans ,Insulin ,Granuloma annulare ,Aged ,Skin ,Necrobiosis Lipoidica ,Scleredema Adultorum ,integumentary system ,business.industry ,Candidiasis ,Bacterial Infections ,Middle Aged ,Diabetic dermopathy ,medicine.disease ,Dermatology ,Surgery ,Sulfonylurea Compounds ,Female ,Insulin Resistance ,medicine.symptom ,business ,Complication - Abstract
Skin manifestations associated with diabetes mellitus are common and, with close scrutiny, can occur in most, if not all, patients. Little information is available on what common pathophysiologic thread is responsible for the skin manifestation and diabetes. Although controlled studies are lacking, a recognition of the skin manifestations, treatment, and prognosis will help patients and their caregivers to understand treatment alternatives more clearly.
- Published
- 1996
92. Scleredema adultorum due to streptococcal infection
- Author
-
Handan Alp, Akın Aktaş, and Zerrin Orbak
- Subjects
Male ,medicine.medical_specialty ,Scleredema Adultorum ,Streptococcus pyogenes ,business.industry ,medicine.disease ,Dermatology ,Streptococcal Infections ,Pediatrics, Perinatology and Child Health ,Immunology ,Scleredema ,medicine ,Humans ,Child ,business - Published
- 2003
93. Successful treatment of poststreptococcal scleredema adultorum Buschke with intravenous immunoglobulins
- Author
-
Nikolaus Schicher, Georg Stingl, Ahmad Jalili, Robert Loewe, Maximilian C. Aichelburg, Franz Karlhofer, and Paul-Gunther Sator
- Subjects
Adult ,medicine.medical_specialty ,Scleredema Adultorum ,business.industry ,Anti-Inflammatory Agents ,Immunoglobulins, Intravenous ,Dermatology ,General Medicine ,medicine.disease ,Methylprednisolone ,Anti-Bacterial Agents ,Intravenous Immunoglobulins ,Streptococcal Infections ,Scleredema ,Medicine ,Humans ,Immunologic Factors ,Penicillin V ,Female ,Ultraviolet Therapy ,business - Abstract
Maximilian C. Aichelburg, MD; Robert Loewe, MD; Nikolaus Schicher, MD; Paul-Gunther Sator, MD; Franz M. Karlhofer, MD; Georg Stingl, MD; Ahmad Jalili, MD, PhD; Divisions of Immunology, Allergy, and Infectious Diseases (Drs Aichelburg, Karlhofer, Stingl, and Jalili) and General Dermatology (Drs Loewe and Schicher), Department of Dermatology, Medical University of Vienna, and Department of Dermatology, Hietzing Municipal Hospital (Dr Sator), Vienna, Austria
- Published
- 2012
94. Scleredema Revisited
- Author
-
Susan M. Swetter and Randy Q. Cron
- Subjects
Male ,Systemic disease ,Pathology ,medicine.medical_specialty ,Scleroderma ,Autoimmune Diseases ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Streptococcal Infections ,030225 pediatrics ,medicine ,Humans ,Child ,Scleroderma, Systemic ,Scleredema Adultorum ,medicine.diagnostic_test ,business.industry ,Pharyngitis ,medicine.disease ,Connective tissue disease ,Pathophysiology ,Pediatrics, Perinatology and Child Health ,Skin biopsy ,Scleredema ,Differential diagnosis ,business ,Complication ,Follow-Up Studies - Abstract
Scleredema is a rare connective disease which must be differentiated from scleroderma in childhood. Scleredema is characterized by thickening of the dermis of the neck, head, and upper trunk. We report a case of scleredema in an 8-year-old boy with coincident streptococcal colonization. The patient report demonstrates many of the common features of scleredema, including an associated streptococcal infection, a relatively benign presentation of illness, and the characteristic mucopolysaccharide intradermal staining on skin biopsy. The literature on scleredema is reviewed, focusing on the disease course, differential diagnosis, and an overview of the proposed three subgroups of scleredema. The association of scleredema to a prior streptococcal infection is explored, and a proposed autoimmune pathophysiology of the disease, as it relates to streptococcal infection, is presented.
- Published
- 1994
95. Widespread scleredema associated with paraproteinemia and generalized osteoarthritis in an HLA-B39 positive patient
- Author
-
Svetlana Popadić, Dušan Škiljević, Darko Antić, Branislava Milenković, and Ljiljana Medenica
- Subjects
Male ,Methotrexate ,Scleredema Adultorum ,scleredema ,paraproteinemia ,HLA-B39 ,osteoarthritis ,Osteoarthritis ,Paraproteinemias ,Humans ,HLA-B39 Antigen ,Middle Aged - Abstract
Scleredema adultorum (SA) is a rare sclerotic disorder characterized by non-pitting induration of the neck with acral progression, sparing hands and feet. We report on a 57-year-old male with severe SA associated with paraproteinemia, treated with methotrexate. Such widespread skin thickening followed by severe movement restriction and inability to function on daily basis, as in our patient, has never been described. Severe osteoarthritis and finding of HLA-B39 allele in association with SA has not been previously described either. To the best of our knowledge, up to 40 patients with SA associated with paraproteinemia has been reported so far, and currently, there is no established effective treatment protocol. In our patient, low-dose methotrexate resulted in stiffness reduction, increased motility of the trunk and extremities, and ability to function on daily basis. We believe that any information about treatment outcome in SA patients should be disseminated in order to establish consensual treatment protocol for this rare disease.
- Published
- 2011
96. Case of diabetic scleredema: diagnostic value of magnetic resonance imaging
- Author
-
Yuichi, Kurihara, Hisashi, Kokuba, and Masutaka, Furue
- Subjects
Diabetes Complications ,Male ,Subcutaneous Tissue ,Diabetes Mellitus, Type 2 ,Scleredema Adultorum ,Humans ,Collagen ,Middle Aged ,Magnetic Resonance Imaging ,Glycosaminoglycans ,Skin - Abstract
We report the case of a patient with a 20-year history of diabetes mellitus type 2 who developed sclerotic skin lesions on his neck and upper back. Physical and histological findings were compatible with diabetic scleredema. T(2)-weighted magnetic resonance imaging (MRI) revealed diffuse thickening of the dermis and subcutaneous tissue, with hyperintense signals. The MRI findings in the dermis corresponded with the accumulation of collagen tissue with deposition of glycosaminoglycans.
- Published
- 2011
97. [Scleredema diabeticorum: successful treatment with UVA-1 phototherapy]
- Author
-
C, Kochs, A, Bockmann, S, Hanneken, and N J, Neumann
- Subjects
Male ,Photosensitizing Agents ,Treatment Outcome ,Scleredema Adultorum ,Humans ,Middle Aged ,PUVA Therapy - Abstract
Scleredema adultorum is characterized by induration of the skin on the neck, shoulders and upper back caused by increased accumulation of collagen and aminoglycans in the dermis. The induration may progress and lead to pronounced restriction of mobility. Scleredema diabeticorum is one type of scleredema adultorum associated with diabetes mellitus. Multiple therapies have been tried, but most of them have not proven to be consistently effective. We report two cases of scleredema diabeticorum treated successfully with UVA-1- as well as physiotherapy and topical corticosteroids; this approach led to improvement in skin changes and mobility.
- Published
- 2011
98. Scleredema of Buschke following Mycoplasma pneumoniae respiratory infection
- Author
-
Paulo, Morais, Marta, Almeida, Paulo, Santos, and Filomena, Azevedo
- Subjects
Adult ,Scleredema Adultorum ,Pneumonia, Mycoplasma ,Humans ,Female ,Mycoplasma pneumoniae ,Skin - Published
- 2011
99. Scleredema adultorum case report
- Author
-
Čabrijan, Leo, Lipozenčić, Jasna, Batinac, Tanja, and Matić Ivanović, Sendi
- Subjects
scleredema adultorum - Abstract
Scleredema adultorum case report
- Published
- 2011
100. Scleredema treated with broad-band ultraviolet A phototherapy plus colchicine
- Author
-
Jale, Yüksek, Engin, Sezer, Doğan, Köseoğlu, Fatma, Markoç, and Havva, Yıldız
- Subjects
Adult ,Young Adult ,Scleredema Adultorum ,Humans ,Female ,Ultraviolet Therapy ,Colchicine ,Combined Modality Therapy ,Tubulin Modulators - Abstract
Scleredema is an uncommon condition characterized by induration of skin. The pathogenesis is not known, although the increased expression of collagen-producing fibroblasts in the skin has been demonstrated. Scleredema has been difficult to treat with scattered reports of success with bath psoralen plus ultraviolet A (PUVA), cream PUVA, UVA1 and others. The use of low-dose broad-band UVA phototherapy was found to be effective in the treatment of morphea. Colchicine has been shown to interfere with collagen synthesis and is used successfully in scleroderma. We report the first case of scleredema that improved markedly with low-dose broad-band UVA plus colchicine treatment.
- Published
- 2010
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