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Your search keyword '"Schulman, Ivonne H."' showing total 78 results
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78 results on '"Schulman, Ivonne H."'

52. Abstract 8: Effectiveness of Combination Allogeneic Stem Cells in a Novel Large Animal Model of Chronic Kidney Disease-induced Heart Failure With Preserved Ejection Fraction (HFpEF)

Author

Castellanos Rieger, Angela, primary, Tompkins, Bryon A, additional, Natsumeda, Makoto, additional, Florea, Victoria, additional, Collon, Kevin, additional, Rodriguez, Jose, additional, Rosado, Marcus, additional, Balkan, Wayne, additional, Hare, Joshua M, additional, and Schulman, Ivonne H, additional

Published
2017
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57. Rescue therapy for hypercapnia due to high PEEP mechanical ventilation in patients with ARDS and renal failure.

Author

Grant, April A., Hart, Valerie J., Lineen, Edward B., Forsberg, Brian C., Klima, Alan, Mirsaeidi, Mehdi, Schulman, Ivonne H., Badiye, Amit, Vianna, Rodrigo M., Patel, Amit, Loebe, Matthias, and Ghodsizad, Ali

Subjects
EXTRACORPOREAL membrane oxygenation, ADULT respiratory distress syndrome, ARTIFICIAL respiration, MEDICAL care, CARBON dioxide
Abstract

Extracorporeal removal of carbon dioxide in patients experiencing severe hypercapnia due to lung protective mechanical ventilation was first described over four decades ago. There have been many devices developed and described in the interim, many of which require additional training, resources, and staff. This manuscript describes a readily available and relatively simple adjunct that can provide partial lung support in patients with acute respiratory distress syndrome complicated by severe hypercapnia and acute kidney injury requiring dialysis. [ABSTRACT FROM AUTHOR]

Published
2019
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58. Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty

Author

Golpanian, Samuel, primary, DiFede, Darcy L., additional, Pujol, Marietsy V., additional, Lowery, Maureen H., additional, Levis-Dusseau, Silvina, additional, Goldstein, Bradley J., additional, Schulman, Ivonne H., additional, Longsomboon, Bangon, additional, Wolf, Ariel, additional, Khan, Aisha, additional, Heldman, Alan W., additional, Goldschmidt-Clermont, Pascal J., additional, and Hare, Joshua M., additional

Published
2016
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60. Detailed Analysis of Bone Marrow From Patients With Ischemic Heart Disease and Left Ventricular Dysfunction

Author

Cogle, Christopher R., primary, Wise, Elizabeth, additional, Meacham, Amy M., additional, Zierold, Claudia, additional, Traverse, Jay H., additional, Henry, Timothy D., additional, Perin, Emerson C., additional, Willerson, James T., additional, Ellis, Stephen G., additional, Carlson, Marjorie, additional, Zhao, David X.M., additional, Bolli, Roberto, additional, Cooke, John P., additional, Anwaruddin, Saif, additional, Bhatnagar, Aruni, additional, da Graca Cabreira-Hansen, Maria, additional, Grant, Maria B., additional, Lai, Dejian, additional, Moyé, Lem, additional, Ebert, Ray F., additional, Olson, Rachel E., additional, Sayre, Shelly L., additional, Schulman, Ivonne H., additional, Bosse, Raphael C., additional, Scott, Edward W., additional, Simari, Robert D., additional, Pepine, Carl J., additional, and Taylor, Doris A., additional

Published
2014
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62. Does Transendocardial Injection of Mesenchymal Stem Cells Improve Myocardial Function Locally or Globally?

Author

Suncion, Viky Y., primary, Ghersin, Eduard, additional, Fishman, Joel E., additional, Zambrano, Juan Pablo, additional, Karantalis, Vasileios, additional, Mandel, Nicole, additional, Nelson, Katarina H., additional, Gerstenblith, Gary, additional, DiFede Velazquez, Darcy L., additional, Breton, Elayne, additional, Sitammagari, Kranthi, additional, Schulman, Ivonne H., additional, Taldone, Sabrina N., additional, Williams, Adam R., additional, Sanina, Cristina, additional, Johnston, Peter V., additional, Brinker, Jeffrey, additional, Altman, Peter, additional, Mushtaq, Muzammil, additional, Trachtenberg, Barry, additional, Mendizabal, Adam M., additional, Tracy, Melissa, additional, Da Silva, Jose, additional, McNiece, Ian K., additional, Lardo, Alberto C., additional, George, Richard T., additional, Hare, Joshua M., additional, and Heldman, Alan W., additional

Published
2014
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64. DOES TRANSENDOCARDIAL INJECTION OF MESENCHYMAL STEM CELLS IMPROVE MYOCARDIAL FUNCTION LOCALLY, OR GLOBALLY: AN ANALYSIS FROM THE POSEIDON TRIAL

Author

Suncion, Viky Y., primary, Ghersin, Eduard, additional, Zambrano, Juan Pablo, additional, Karantalis, Vasileios, additional, Mandel, Nicole S., additional, Nelson, Katarina H., additional, Fishman, Joel E., additional, Gerstenblith, Gary, additional, Velazquez, Darcy L. DiFede, additional, Breton, Elayne, additional, Schulman, Ivonne H., additional, Sitammagari, Kranthi, additional, Johnston, Peter V., additional, Brinker, Jeffrey, additional, Altman, Peter, additional, Mushtaq, Muzammil, additional, Trachtenberg, Barry, additional, Silva, Jose Da, additional, McNiece, Ian K., additional, Lardo, Albert C., additional, George, Richard T., additional, Hare, Joshua M., additional, and Heldman, Alan W., additional

Published
2013
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73. Abstract 16034: Femalecompared to Male MSC-Derived Exosomes: Females?Are Superior for Promotingipsc Differentiation and Proliferation

Author

Wanschel, Amarylis B, Salerno, Alessandro, Hatzistergos, Konstantinos, Yu, Wendou, Schulman, Ivonne H, Balkan, Wayne, and Hare, Joshua M

Abstract

Introduction:Myocardial ischemia (MI) is a leading cause of morbidity and mortality worldwide. Mesenchymalstemcell(MSC) treatment of MI reduces scar size and improves perfusion and heart function. While few MSCs are retained, improvements followingMSC-based therapies have been attributed to paracrine effects, in whichexosomes(Exos) may play a major role.HYPOTHESIS:The effectiveness ofby MSC-derived exosomes (MSC-Exos) is sex-dependent.Methods:MSC-Exos were isolated from conditioned medium via ultracentrifu-gation. Flow cytometry analysis, transmission electron microscopy, and nanosight were used to identify and quantifyexosomes. Human inducedpluripotentstemcells (hiPSCs) and human-MSCs (hMSCs) were co-cultured under hypoxic (1% O2) conditions. We evaluated the effects of male and female MSC-Exos on differentiation and proliferation of hiPSCs by qPCR and MTT assays, respectively. Exosomal microRNAs (miRs) were subjected to microarray profiling analysis and WNT signaling was assessed by Western blot.Results:Most MSC-Exos were ~50-150 nm in diameter and expressed CD9, CD63, and CD81. Female MSC-Exos increased hiPSC expression of NKX2.5 and WNT signaling compared to treatment with male MSC-Exos. Similarly, hiPSCs proliferation was stimulated by both female and male MSC-Exos, with female MSC-Exos exerting a greater effect. Expression of miR302b and miR181b were significantly different in female compared to male MSC-Exos .Conclusions:We demonstrated that female MSC-Exos have a greater effect on hiPSC differentiation and proliferation than male MSC-Exos. We predict that miR302b promotes differentiation of hiPSCs into cardiac progenitor cells in a sex-specific manner and that miR181b enhances proliferation through activating the WNT signaling pathway of hiPSCs, potentially increasing cardiomyocyte proliferation.

Published
2019
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76. Abstract 1.

Author

Bellio, Michael, Rodrigues, Claudia O, Florea, Victoria, Balkan, Wayne, Hare, Joshua M, and Schulman, Ivonne H

Published
2014

77. Cell-based therapy for prevention and reversal of myocardial remodeling.

Author

Karantalis V, Balkan W, Schulman IH, Hatzistergos KE, and Hare JM

Subjects
Animals, Cardiomyopathies pathology, Cardiomyopathies physiopathology, Cell Differentiation, Cell Proliferation, Cell Survival, Humans, Myocardial Ischemia pathology, Myocardial Ischemia physiopathology, Recovery of Function, Regeneration, Treatment Outcome, Cardiomyopathies surgery, Myocardial Ischemia surgery, Myocardium pathology, Stem Cell Transplantation, Ventricular Remodeling
Abstract

Although pharmacological and interventional advances have reduced the morbidity and mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies that prevent or reverse progressive ventricular remodeling following myocardial infarction, the process that forms the substrate for ventricular failure. The development of cell-based therapy as a strategy to repair or regenerate injured tissue offers extraordinary promise for a powerful anti-remodeling therapy. In this regard, the field of cell therapy has made major advancements in the past decade. Accumulating data from preclinical studies have provided novel insights into stem cell engraftment, differentiation, and interactions with host cellular elements, as well as the effectiveness of various methods of cell delivery and accuracy of diverse imaging modalities to assess therapeutic efficacy. These findings have in turn guided rationally designed translational clinical investigations. Collectively, there is a growing understanding of the parameters that underlie successful cell-based approaches for improving heart structure and function in ischemic and other cardiomyopathies.

Published
2012
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78. Concise review: the role of clinical trials in deciphering mechanisms of action of cardiac cell-based therapy.

Author

Suncion VY, Schulman IH, and Hare JM

Subjects
Animals, Disease Models, Animal, Endpoint Determination, Evidence-Based Medicine, Heart Diseases pathology, Heart Diseases physiopathology, Humans, Phenotype, Recovery of Function, Regeneration, Treatment Outcome, Ventricular Function, Ventricular Remodeling, Clinical Trials as Topic, Heart Diseases surgery, Myocardium pathology, Stem Cell Transplantation
Abstract

Although the initial promise of cardiac cell-based therapy was based on the concept that stem cells engraft into diseased tissue and differentiate into beating cardiomyocytes, it is now clear that successful cell-based tissue repair involves a more complex orchestration of cellular and molecular events. Many lessons about successful tissue repair can be gleaned from the results of early-stage clinical trials. This body of work shows that cell-based therapy (with various cell sources and delivery methods) effectively prevents and reverses the remodeling process, the sine qua non of the myocardial injury reaction and anatomic substrate for subsequent clinical events. The potentially favorable remodeling responses to cell therapy have prompted a search for mechanisms of action beyond cell repopulation and guided future clinical trial design by providing more clear focus on pathophysiological endpoints signifying favorable responses to cell-based therapy. Perhaps the most important mechanistic insight is that endogenous stem/precursor cells have the potential to participate in tissue healing. With regard to the phenotype of cellular response, it is clear that parameters of remodeling, such as infarct size and ventricular dimensions, should be directly measured, thereby necessitating the use of sophisticated imaging modalities, such as cardiac magnetic resonance imaging or multidetector computed tomography. These new insights offer an optimistic outlook on the state of cell-based therapeutics for cardiac disease and suggest that pivotal clinical trials are warranted. Here, we review lessons learned from clinical trials and evaluate the choice and assessment of endpoints to best predict efficacy of cell therapy.

Published
2012
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