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51. Evidence for bradykinin as a stimulator of thirst

Author

Cadnapaphornchai, Melissa A., Rogachev, Boris, Summer, Sandra N., Chen, Yung-Chang, Gera, Lajos, Stewart, John M., and Schrier, Robert W.

Subjects
Bradykinin -- Research, Biological sciences
Abstract

Angiotensin-converting enzyme inhibition (ACEI) with captopril has been shown to increase water intake and urine output in rats, but the mechanism is unknown. ACEI impairs the conversion of ANG I to ANG 11, a dipsogenic hormone, and impairs the degradation of bradykinin. The goal of this study was to examine the role of bradykinin in the polydipsia and polyuria associated with ACEI. Male Sprague-Dawley rats received captopril (CPT; 20 mg x [kg.sup.-1] x [day.sup.-1]) in ground chow for 48 h. Water intake, food intake, and urine output were monitored and compared with control rats (CTL), rats receiving captopril treatment with limited water intake (CPT-LIM), and rats receiving captopril treatment with ad libitum water intake plus 24-h treatment with the bradykinin antagonist B-9430 (CPT-BK1). CPT rats consumed significantly more water and produced more urine vs. CTL. Urine osmolality was significantly decreased in CPT rats vs. CTL. Inner medullary aquaporin-2 (AQP2) protein abundance was also markedly decreased in CPT rats vs. CTL. These findings were reversed in CPT-LIM rats, suggesting captopril-induced primary polydipsia. CPT-BKI rats demonstrated parameters no different from CTL despite ad libitum water intake. Mean arterial pressure and 24-h creatinine clearance did not differ among groups. We conclude that ACEI with captopril induces primary polydipsia despite impaired production of the dipsogen ANG II and that this primary increase in water intake is likely the cause of the decreased protein abundance of inner medullary AQP2. Furthermore, this dipsogenic effect was reversed by antagonism of bradykinin, thus implicating this hormone in thirst regulation in the rat. angiotensin-converting enzyme inhibition; aquaporin

Published
2004

58. Contributors

Author

Abraham, Edward, primary, Abrams, Peter, additional, Abu-Elmagd, Kareem, additional, Abu-Omar, Yasir, additional, Agustí, Carlos, additional, Aird, William C., additional, Alapat, Philip, additional, Al-Khafaji, Ali H., additional, Angaramo, Gustavo G., additional, Angus, Derek C., additional, Antoniadou, Anastasia, additional, Anupam, Anupam, additional, Argent, Andrew C., additional, Arnold, John H., additional, Arroyo, Anna, additional, Ashwal, Stephen, additional, Astiz, Mark E., additional, Azoulay, Elie, additional, Bajwa, Omer A., additional, Baldea, Anthony, additional, Baldisseri, Marie R., additional, Balogh, Zsolt J., additional, Balogun, Rasheed Abiodun, additional, Banerjee, Arna, additional, Barie, Philip S., additional, Barrett, Brendan, additional, Bartlett, Robert, additional, Bartlett,, John G., additional, Bassi, Gianluigi Li, additional, Bassin,, Sarice L., additional, Bastarache, Julie A., additional, Bauer, Colin, additional, Bausch, Daniel G., additional, Bayýr, Hülya, additional, Bearden, David T., additional, Beilman, Gregory J., additional, Bellomo, Rinaldo, additional, Bennett, E. David, additional, Bernard, Gordon R., additional, Bhama, Jay K., additional, Bierens, Joost J.L.M., additional, Biffl, Walter L., additional, Bleck, Thomas P., additional, Bledsoe, Thomas A., additional, Bloch, Karen C., additional, Bloos, Frank, additional, Bohn, Desmond, additional, Bouchard, Nicole C., additional, Boujoukos, Arthur J., additional, Brady, William J., additional, Brimioulle, Serge, additional, Brooks, Daniel E., additional, Brundage, Richard C., additional, Burns, Jeffrey P., additional, Cabello, Belén, additional, Calhoun, Karen H., additional, Callaway, Clifton W., additional, Calverley, Peter M.A., additional, Camm, John, additional, Cappelletty, Diane M., additional, Carcillo, Joseph A., additional, Carlese, Anthony J., additional, Carlos-Puyana, Juan, additional, Carnevale, Franco A., additional, Chan, Edward D., additional, Chawla, Sanjay, additional, Chelluri, Lakshmipathi, additional, Chen, David C., additional, Chevrier, Annie S., additional, Cho, Su Min, additional, Clark, Robert S.B., additional, Coady, Michael A., additional, Cohn, Stephen M., additional, Cook, Alan D., additional, Cook, Deborah J., additional, Cooney, Robert N., additional, Corbridge, Susan J., additional, Corbridge, Thomas C., additional, Corwin, Howard L., additional, Crowther,, Mark A., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, Curtis, J. Randall, additional, D’Intini, Vincenzo, additional, Daeihagh, Pirouz, additional, Darby, Joseph M., additional, Dargin, James M., additional, Darmon, Michaël, additional, Dasta, Joseph F., additional, Davies, John D., additional, Derlet, Robert W., additional, Dershwitz, Mark, additional, de Smet, Anne Marie G.A., additional, Dhand,, Monica, additional, Dhillon, Anahat, additional, Dhupar,, Rajeev, additional, Diringer, Michael N., additional, Doelken, Peter, additional, Donahoe, Michael, additional, Donahue, Timothy R., additional, Dries, David J., additional, DuBose, Thomas D., additional, Duthie, Susan, additional, Edwards, Randy, additional, Eggimann, Philippe, additional, Elhassan, Waleed A., additional, Ely, E. Wesley, additional, Emeriaud, Guillaume, additional, Eschenauer, Gregory A., additional, Ettinger, Joel H., additional, Ettinger, Joshua H., additional, Evans, David Clay, additional, Everson, Gregory T., additional, Exner, Derek V., additional, Falk, Ronald J., additional, Farrar,, Jeremy, additional, Farwell, Alan P., additional, Felmet, Kathryn, additional, Ferguson, Niall D., additional, Ferrer, Miguel, additional, Fink, Mitchell P., additional, Fink, Ericka L., additional, Fish, Douglas N., additional, Florescu, Diana F., additional, Fortune, Brett E., additional, Freeman, Bradley D., additional, Froberg, Blake, additional, Fung, John J., additional, Furbee, Brent, additional, Gamelli, Richard L., additional, Gazmuri, Raúl J., additional, Geelkerken, Robert H., additional, Gehr, Todd W.B., additional, Gentile, Michael A., additional, George, M. Patricia, additional, Gerlach, Herwig, additional, Ghobrial,, R. Mark, additional, Giamarellou, Helen, additional, Ginsberg, Fredric, additional, Gleason, Thomas G., additional, Goldstein,, Jacques P., additional, Gomez, Hernando, additional, Burroughs, Sherilyn Gordon, additional, Gradon, Jeremy David, additional, Graves, Cornelia R., additional, Gregoretti, Cesare, additional, Groeger, Jeffrey S., additional, Grounds, R. Michael, additional, Gubbins, Paul O., additional, Gunnerson, Kyle J., additional, Habib, Fahim A., additional, Halperin, Mitchell L., additional, Hartman, Mary E., additional, Harvey, Maurene A., additional, Hassan, Moustafa A., additional, Hayashi, Yoshiro, additional, Hazelzet, Jan A., additional, Heard, Stephen O., additional, Hébert, Paul C., additional, Hermsen, Elizabeth D., additional, Heyland, Daren K., additional, Hiatt, Jonathan R., additional, Hickey,, Robert W., additional, Hien, Tran Tinh, additional, Higgins, Thomas L., additional, Hill, Nicholas S., additional, Hojman, Horacio, additional, Hollenberg, Steven M., additional, Huggins, J. Terrill, additional, Huang, David T., additional, Hughes, Christopher G., additional, Hull, Russell D., additional, Isaac, Margaret, additional, Isbister, James P., additional, Jastremski, Connie, additional, Jenkins, Larry, additional, Jodka, Paul, additional, Johnson, Robert G., additional, Jorens, Philippe G., additional, Juel, Vern C., additional, Jung, Rose, additional, Kahl, Christina R., additional, Kalil, Andre C., additional, Kaluski, Edo, additional, Kamel, Kamel S., additional, Kane-Gill, Sandra, additional, Kanne, Jeffrey P., additional, Karlin,, Lionel, additional, Kartalija, Marinka, additional, Kasiewicz,, James, additional, Katz, Kenneth D., additional, Kaufman, David, additional, Kellum, John A., additional, Kingston, Rick, additional, Kirton, Orlando C., additional, Kleinschmidt, Kurt, additional, Knight, Jason, additional, Kochanek, Patrick M., additional, Kofke, W. Andrew, additional, Kolkman, Jeroen J., additional, Kormos, Robert L., additional, Kozar, Rosemary A., additional, Kramer, David J., additional, Kreit, John W., additional, Kruse, James A., additional, Kumar, Anand, additional, Kvetan, Vladimir, additional, Lacroix, Jacques, additional, Lebuffe,, Gilles, additional, Lemiale, Virginie, additional, Leung, Angela M., additional, Leung, Sharon, additional, Levi, Allan D., additional, Levin, Phillip D., additional, Levy, Mitchell M., additional, Liang, Mah Chou, additional, Liebman, Scott, additional, Linas, Stuart L., additional, Lip, Gregory Y.H., additional, Lipsett, Pamela A., additional, Lisbon, Alan, additional, Lucena, Carmen, additional, Maas, Andrew I.R., additional, MacIntyre, Neil R., additional, Macrae, Duncan, additional, Maisch, Bernhard, additional, Malik, Amer M., additional, Mancebo, Jordi, additional, Mann, Henry J., additional, Manocha, Sanjay, additional, Manzo-Silberman, Stéphane, additional, Marik, Paul E., additional, Marini, John J., additional, Marion, Donald W., additional, Martin, Steven J., additional, Martinez-Camacho, Alvaro, additional, Mattingly, Anne Marie, additional, Matzke, Gary R., additional, Max,, Adeline, additional, Mazariegos, George V., additional, Mazzarelli, Joanne, additional, McClave, Stephen A., additional, McEnaney,, Ryan M., additional, McIllwaine,, John K., additional, McNutt, Michelle K., additional, Mehta, Sangeeta, additional, Mesotten, Dieter, additional, Meyer,, Kimberly S., additional, Michelson, David J., additional, Minha, Saar, additional, Mirski, Marek A., additional, Mohammad, Rima A., additional, Monnet, Xavier, additional, Moore, Frederick A., additional, Moore, Laura J., additional, Moreau, Anne-Sophie, additional, Moreau,, Delphine, additional, Morris, Alison, additional, Morris, Amy E., additional, Mourvillier, Bruno, additional, Munger, Mark A., additional, Murugan, Raghavan, additional, Muth, Claus-Martin, additional, Naber, Kurt G., additional, Napolitano, Lena M., additional, Nasraway, Stanley A., additional, Navarro,, Jovany Cruz, additional, Nelson, Lewis S., additional, Niederman, Michael S., additional, Njoku, Jessica C., additional, Norwood, Scott, additional, Ochoa, Juan B., additional, Okusa, Mark D., additional, Olsen, Keith M., additional, Opal, Steven M., additional, Orlowski, James P., additional, Otto, Catherine M., additional, Oudemans-van Straaten, Heleen M., additional, Pandharipande, Pratik P., additional, Parrillo, Joseph E., additional, Paterson, David L., additional, Paulin, Frédéric L., additional, Peitzman, Andrew B., additional, Penoyer, Daleen Aragon, additional, Peterson, Bradley, additional, Pineo, Graham F., additional, Pinsky, Michael R., additional, Piper, Greta, additional, Pittet, Didier, additional, Plum, Fred, additional, Pollack, Murray M., additional, Ponce, Lucido L., additional, Pousman, Robert, additional, Pronovost, Peter J., additional, Radwański, Przemyslaw B., additional, Rainey, Thomas G., additional, Rajan, Thomas, additional, Ranieri, Vito Marco, additional, Reinhart, Konrad, additional, Reyes, Jorge, additional, Rhodes, Andrew, additional, Ricci, Zaccaria, additional, Richard, Christian, additional, Richards, John R., additional, Riordan, John, additional, Ristic, Arsen D., additional, Rizoli, Sandro, additional, Robertson, Claudia S., additional, Robin, Emmanuel, additional, Roche-Campo, Ferran, additional, Rogers, Paul, additional, Ronco, Claudio, additional, Rotschafer, John C., additional, Rubenfeld, Gordon D., additional, Ruppel, Randall A., additional, Russo, Laura T., additional, Rusyniak, Daniel E., additional, Sahn, Steven A., additional, Salgado, Juan C., additional, Santonocito, Cristina, additional, Sappington, Penny Lynn, additional, Sarko, John, additional, Savel, Richard H., additional, Savelieva,, Irina, additional, Schlemmer,, Benoit, additional, Schofield, Minka, additional, Schonder, Kristine S., additional, Schoolwerth,, Anton C., additional, Schrier, Robert W., additional, Schulman, Carl, additional, Schwarz, Evan, additional, Scifres, Aaron M., additional, Seger, Donna L., additional, Seguin, Amelie, additional, Sellke, Frank W., additional, Shahul, Sajid, additional, Shamseddin, M. Khaled, additional, Shank, Erik S., additional, Shantsila, Eduard, additional, Sharma, Kapil, additional, Sheridan, Robert L., additional, Shiloh, Ariel L., additional, Skaar, Debra J., additional, Slonim, Anthony D., additional, Smith Jacobs,, Teresa L., additional, Solís-Muñoz, Pablo, additional, Sosin, Michael D., additional, Sprung, Charles L., additional, Squadrone,, Vincenzo, additional, Starzl,, Thomas E., additional, Steinberg, Steven M., additional, Steinhorn, David M., additional, Stern, Eric J., additional, Stewart, Thomas E., additional, Stocchetti, Nino, additional, Stübgen, Joerg-Patrick, additional, Subramanian, Sanjay, additional, Szawlewicz, Justin, additional, Szpilman, David, additional, Taggart, David P., additional, Talmor,, Daniel, additional, Teboul, Jean-Louis, additional, Teitelbaum, Isaac, additional, Thom, Stephen R., additional, Thwaites, C. Louise, additional, Timsit, Jean-François, additional, Tinmouth, Alan, additional, Tisherman, Samuel A., additional, Todd, S. Rob, additional, Torres, Antoni, additional, Truog, Robert D., additional, Turner, Krista, additional, Tzeng, Edith, additional, Uriel, Nir, additional, Vallet, Benoit, additional, Van den Berghe, Greet, additional, van Heerden, P. Vernon, additional, Van Tassell, Benjamin W., additional, Eynden, Frédéric Vanden, additional, Varenne, Olivier, additional, Venkataraman, Ramesh, additional, Ventre, Kathleen M., additional, Vered, Zvi, additional, Vincent, Jean-Louis, additional, Vitarbo,, Elizabeth A., additional, Voigt, Louis, additional, Wagenlehner, Florian M.E., additional, Wai, Christina J., additional, Walley, Keith R., additional, Ward, Nicholas S., additional, Ware, Lorraine B., additional, Weber, Robert J., additional, Wechsler, Lawrence R., additional, Weill, David, additional, Weinert, Craig R., additional, Wendon, Julia, additional, Wolff, Michel, additional, Wrigley, Benjamin, additional, Wunderink, Richard G., additional, Yen, Lam M., additional, Zanotti-Cavazzoni, Sergio L., additional, Zazulia, Allyson R., additional, Zimmerman, Janice, additional, and Zingg, Walter, additional

Published
2011
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60. Effect of primary polydipsia on aquaporin and sodium transporter abundance

Author

Cadnapaphornchai, Melissa A., Summer, Sandra N., Falk, Sandor, Thurman, Joshua M., Knepper, Mark A., and Schrier, Robert W.

Subjects
Urinary organs -- Research, Biological sciences
Abstract

Cadnapaphornchai, Melissa A., Sandra N. Summer, Sandor Falk, Joshua M. Thurman, Mark A. Knepper, and Robert W. Schrier. Effect of primary polydipsia on aquaporin and sodium transporter abundance. Am J Physiol Renal Physiol 285: F965-F971, 2003. First published July 22, 2003; 10.1152/ajprenal.00085.2003.--Chronic primary polydipsia (POLY) in humans is associated with impaired urinary concentrating ability. However, the molecular mechanisms responsible for this finding have not been elucidated. The purpose of this study was to examine the effect of chronic primary POLY on water metabolism and renal aquaporin (AQP) water channels and sodium and urea transporter abundance in rats. Primary POLY was induced in male Sprague-Dawley rats by daily administration of 15 g powdered rat chow mixed in 100 ml water for 10 days. Control rats (CTL) received 15 g powdered rat chow per day and ad libitum drinking water. Rats were studied following this period before further intervention and with a 36-h period of water deprivation to examine maximal urinary concentrating ability. At baseline, POLY rats demonstrated significantly greater water intake (100[+ or -]1 vs. 22[+ or -]2 ml/day, P < 0.0001) and urinary output (80[+ or -]1 vs. 11[+ or -]1 ml/day, P < 0.0001) and decreased urinary osmolality (159[+ or -]13 vs. 1,365[+ or -]188 mosmol/kg[H.sub.2]O, P < 0.001) compared with CTL rats. These findings were accompanied by decreased inner medulla AQP-2 protein abundance in POLY rats compared with CTL rats before water deprivation (76[+ or -]2 vs. 100[+ or -]7% CTL mean, P < 0.007). With water deprivation, maximal urinary osmolality was impaired in POLY vs. CTL rats (2,404[+ or -]148 vs. 3,286[+ or -]175 mosmol/kg[H.sub.2]O, P < 0.0005). This defect occurred despite higher plasma vasopressin concentrations and similar medullary osmolalities in POLY rats. In response to 36-h water deprivation, inner medulla AQP-2 protein abundance was decreased in POLY rats compared with CTL rats (65[+ or -]5 vs. 100[+ or -]5% CTL mean, P < 0.0006). No significant differences were noted in renal protein abundance of either AQP-3 or AQP-4 or sodium and urea transporters. We conclude that the impaired urinary concentrating ability associated with primary POLY in rats is due to impaired osmotic equilibration in the collecting duct that is mediated primarily by decreased AQP-2 protein abundance. urinary concentrating ability

Published
2003

62. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure

Author

Wang Wei, Jittikanont, Suparoek, Falk, Sandor A., Li, Ping, Feng, Lili, Gengaro, Patricia E., Poole, Brian D., Bowler, Russell P., Day, Brian J., Crapo, James D., and Schrier, Robert W.

Subjects
Physiology -- Research, Nitric oxide -- Physiological aspects, Biological sciences
Abstract

Acute renal failure (ARF) during sepsis is associated with increased nitric oxide (NO) and oxygen radicals, including superoxide ([O.sup.-.sub.2]). Because [O.sup.-.sub.2] reacts with NO in a rapid manner, it plays an important role in modulating NO levels. Therefore, scavenging of [O.sup.-.sub.2] by superoxide dismutase (SOD) may be critical for preserving NO bioavailability. In mice, substantial renal extracellular SOD (ECSOD) expression implies its important role in scavenging [O.sup.-.sub.2] in the kidney. We hypothesized that during endotoxemic ARF, EC-SOD is decreased in the kidney, resulting in increased [O.sup.-.sub.2] and thus decreased vascular NO bioavailability with resultant renal vasoconstriction and ARF. In the present study, normotensive endotoxemic ARF was induced in mice using lipopolysaccharide (LPS; 5 mg/kg ip). Sixteen hours after LPS, glomerular filtration rate (GFR; 50 [+ or -] 16 vs. 229 [+ or -] 21 [micro]l/min, n = 8, P < 0.01) and renal blood flow (RBF; 0.61 [+ or -] 0.10 vs. 0.86 [+ or -] 0.05 ml/min, n = 8, P < 0.05) were subsequently decreased. EC-SOD mRNA and protein expression in endotoxemic kidneys were decreased at 16 h compared with controls. A catalytic antioxidant, metalloporphyrin, reversed the deleterious effects of endotoxemia on renal function as GFR (182 [+ or -] 40 vs. 50 [+ or -] 16 [micro]l/min, n = 6, P < 0.01) and RBF (1.08 [+ or -] 0.10 vs. 0.61 [+ or -] 0.10 ml/min, n = 6, P < 0.05) were preserved. Similar results were obtained with tempol, a chemically dissimilar antioxidant. Specific inhibition of inducible nitric oxide synthase (iNOS), L-[N.sup.6]-(1-iminoethyl)-lysine, reversed the renal protective effect on GFR and RBF observed with antioxidant treatment during endotoxemia. In summary, renal EC-SOD expression is decreased during endotoxemia. Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia. sepsis; extracellular superoxide dismutase; lipopolysaccharide; kidney

Published
2003

65. Contributors

Author

Adler, Sharon, primary, Adrogué, Horacio J., additional, Aiyagari, Venkatesh, additional, Alpern, Robert J., additional, Alpers, Charles E., additional, Appel, Gerald B., additional, Arogundade, Fatiu A., additional, Ash, Stephen R., additional, Asif, Arif, additional, Aucouturier, Pierre, additional, August, Phyllis, additional, Bakris, George L., additional, Barlow, Adam D., additional, Barsoum, Rashad S., additional, Baylis, Chris, additional, Bello, Aminu, additional, Berl, Tomas, additional, Bhat, Suresh, additional, Bircher, Gemma, additional, Bonventre, Joseph V., additional, Bouchard, Josée, additional, Brook, Nicholas R., additional, Brown, Christopher, additional, Brown, Mark A., additional, Burdmann, Emmanuel A., additional, Bushinsky, David A., additional, Cattran, Daniel C., additional, Cervelli, Matthew J., additional, Chadban, Steven J., additional, Charlton, Karen E., additional, Chen, Yipu, additional, Cheng, Ignatius K.P., additional, Connolly, John O., additional, Couser, William G., additional, Cravedi, Paolo, additional, D’Agati, Vivette D., additional, Danovitch, Gabriel M., additional, Davies, Simon J., additional, Davison, John M., additional, Derman, Wayne, additional, DiBona, Gerald F., additional, Drüeke, Tilman B., additional, Dwyer, Jamie P., additional, Eckardt, Kai-Uwe, additional, Eckel, Jason, additional, Eitner, Frank, additional, Kossi, Mohsen El, additional, Elger, Marlies, additional, Elhassan, Elwaleed A., additional, Evenepoel, Pieter, additional, Fabian, June, additional, Falk, Ronald J., additional, Feehally, John, additional, Fischer, Evelyne A., additional, Fisher, Jonathan S., additional, Floege, Jürgen, additional, Fogazzi, Giovanni B., additional, Foreman, John W., additional, Fujita, Toshiro, additional, Gennari, F. John, additional, Gkougkousis, Evangelos G., additional, Glassock, Richard J., additional, Gorelick, Philip B., additional, Greco, Barbara A., additional, Gross, Peter, additional, Guay-Woodford, Lisa M., additional, Haddad, Nabil, additional, Harris, Kevin P.G., additional, Harris, Peter C., additional, Hebert, Lee A., additional, Heduschka, Peter, additional, Herzog, Charles A., additional, Hooton, Thomas, additional, Hörl, Walter H., additional, Hoyer, Peter F., additional, Hughes, Jeremy, additional, Hugo, Christian, additional, Imai, Enyu, additional, Irish, Ashley B., additional, Jaber, Bertrand L., additional, Jain, Sunjay, additional, Jayne, David, additional, Jefferson, J. Ashley, additional, Jennette, J. Charles, additional, Jha, Vivekanand, additional, Johnson, Richard J., additional, Kanagasundaram, Nigel S., additional, Kanellis, John, additional, Karumanchi, S. Ananth, additional, Kashtan, Clifford E., additional, Kauffman, Carol A., additional, Kawar, Bisher, additional, Kestenbaum, Bryan, additional, Ketteler, Markus, additional, Kopp, Jeffrey, additional, Kotanko, Peter, additional, Kriz, Wilhelm, additional, Kuhlmann, Martin K., additional, Kuypers, Dirk R., additional, Lakey, Jonathan R.T., additional, Lambert, Estelle V., additional, Lawton, William, additional, Levey, Andrew S., additional, Levin, Nathan W., additional, Levy, Jeremy, additional, Lewington, Andrew, additional, Lewis, Julia B., additional, Li, Felix F.K., additional, Linas, Stuart L., additional, Luft, Friedrich C., additional, Maaten, Jan C. ter, additional, Macdougall, Iain C., additional, Macedo, Etienne, additional, Madias, Nicolaos E., additional, Magee, Colm C., additional, Marsh, Christopher L., additional, Marshall, Mark R., additional, Martin, Kevin J., additional, Mason, Philip D., additional, Mathews, Ranjiv, additional, Mattoo, Tej K., additional, Mehta, Ravindra L., additional, Meier-Kriesche, Herwig-Ulf, additional, Mellon, J. Kilian, additional, Mirbolooki, M. Reza, additional, Monk, Rebeca D., additional, Moulin, Bruno, additional, Mulley, William R., additional, Nahas, Meguid El, additional, Naicker, Saraladevi, additional, Nangaku, Masaomi, additional, Neild, Guy H., additional, Nicholls, M. Gary, additional, Nicholson, Michael L., additional, O’Connell, Philip J., additional, O’Neill, W. Charles, additional, Palmer, Biff F., additional, Parikh, Chirag, additional, Pham, Phuong-Chi T., additional, Pham, Phuong-Thu T., additional, Pham, Son V., additional, Phelps, Richard G., additional, Pichler, Raimund, additional, Podymow, Tiina, additional, Pommer, Wolfgang, additional, Pusey, Charles D., additional, Rabb, Hamid, additional, Rayner, Brian, additional, Rayner, Hugh C., additional, Remuzzi, Giuseppe, additional, Richards, A. Mark, additional, Rippe, Bengt, additional, Ritz, Eberhard, additional, Robertson, R. Paul, additional, Rodriguez-Iturbe, Bernardo, additional, Ronco, Claudio, additional, Ronco, Pierre M., additional, Ross, Edward A., additional, Rossert, Jerome A., additional, Ruggenenti, Piero, additional, Ruland, Sean, additional, Russ, Graeme R., additional, Samuels, Martin A., additional, Sarafidis, Pantelis A., additional, Schena, F. Paolo, additional, Schold, Jesse D., additional, Schrier, Robert W., additional, Seabra, Victor F., additional, Segal, Mark S., additional, Seifter, Julian Lawrence, additional, Shastri, Shani, additional, Shirley, David G., additional, Sitprija, Visith, additional, Srinivas, Titte R., additional, Stenvinkel, Peter, additional, Stevens, Lesley A., additional, Textor, Stephen C., additional, Thurman, Joshua M., additional, Tong, Li-Li, additional, Topham, Peter S., additional, Tordoir, Jan H.M., additional, Torres, Vicente E., additional, Trence, Dace, additional, Turner, A. Neil, additional, Unwin, Robert J., additional, Vacher-Coponat, Henri, additional, Visweswaran, R. Kasi, additional, Wasse, Haimanot, additional, Wavamunno, Moses D., additional, Weiner, I. David, additional, Wheeler, David C., additional, Williams, Bryan, additional, Williams, John D., additional, Wingo, Charles S., additional, Winn, Michelle, additional, Wiseman, Alexander C., additional, Wolf, Gunter, additional, Womer, Karl, additional, Woodrow, Graham, additional, Wymer, David C., additional, Yang, Li, additional, and Yu, Xueqing, additional

Published
2010
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69. Protective effect of renal denervation on normotensive endotoxemia-induced acute renal failure in mice

Author

Wang Wei, Falk, Sandor A., Jittikanont, Suparoek, Gengaro, Patricia E., Edelstein, Charles L., and Schrier, Robert W.

Subjects
Cytochemistry -- Research, Molecular biology -- Research, Kidneys -- Physiological aspects, Mice -- Physiological aspects, Acute renal failure -- Physiological aspects, Denervation -- Physiological aspects, Endotoxins -- Physiological aspects, Glomerular filtration rate -- Physiological aspects, Epinephrine -- Physiological aspects, Noradrenaline -- Physiological aspects, Bacterial infections -- Physiological aspects, Biological sciences
Abstract

Acute renal failure (ARF) contributes substantially to the high morbidity and mortality observed during endotoxemia. We hypothesized that selective blockade of the renal nerves would be protective against ARF during the early (16 h) stage of endotoxemia [5 mg lipopolysaccharide (LPS)/kg ip in mice]. At 16 h after LPS, there was no change in mean arterial pressure, but plasma epinephrine (4,604 [+ or -] 719 vs. 490 [+ or -] 152 pg/ml, P < 0.001), norepinephrine (2,176 [+ or -] 306 vs. 1,224 [+ or -] 218 pg/ml, P < 0.05), and plasma renin activity (40 [+ or -] 5 vs. 27 [+ or -] 2 ng*[ml-.sup.-1]*[h.sup.-1], P < 0.05) were higher in the LPS-treated vs. control mice. The high plasma renin activity level decreased to the control level with renal denervation in endotoxemic mice. After intravenous injection of phentolamine (200 [micro]g/kg), the decrement in mean arterial pressure was significantly greater in LPS-treated vs. control mice (19.4 [+ or -] 3.5 vs. 8.1 [+ or -] 1.5 mmHg, P < 0.01). Sixteen hours after LPS administration, there were significant decreases in glomerular filtration rate (52 [+ or -] 18 vs. 212 [+ or -] 23 [micro]l/min, P < 0.01) and renal blood flow (0.58 [+ or -] 0.08 vs. 0.85 [+ or -] 0.06 ml/min, P < 0.01) in sham-operated mice. The decrement in glomerular filtration rate during endotoxemia was significantly attenuated in mice with denervated kidneys (32 vs. 79%). Moreover, there was no change in renal blood flow during endotoxemia in mice with renal denervation. The present results therefore demonstrate a protective role of renal denervation during normotensive endotoxemia-related ARF in mice, an effect that may be, at least in part, due to a diminished activation of the renin-angiotensin system. glomerular filtration rate; renal blood flow; epinephrine; norepinephrine; sepsis

Published
2002

71. List of Contributors

Author

Adler, Gail K., primary, Ayus, Juan Carlos, additional, Bakris, George, additional, Berl, Tomas, additional, Bollag, Wendy B., additional, Brown, Alex J., additional, Burnett, John C., additional, Cai, Zheqing, additional, Carey, Robert M., additional, Catanzaro, Daniel F., additional, Coghlan, John, additional, Dusso, Adriana S., additional, Ecelbarger, Carolyn A., additional, Ferrario, Carlos M., additional, Friedman, Peter A., additional, Galigniana, Mario, additional, Garg, Rajesh, additional, Gomez-Sanchez, Celso E., additional, Gomez-Sanchez, Elise P., additional, Isales, Carlos M., additional, Jüppner, Harald, additional, Ananth Karumanchi, S., additional, Keithi-Reddy, Sairam, additional, Ko, Benjamin, additional, Kraut, Jeffrey A., additional, Lam, Chun, additional, Lee, Candace Y.W., additional, Lim, Victoria S., additional, Lin, Herbert Y., additional, Macdougall, Iain C., additional, Mahan, John D., additional, Menard, Joel, additional, Mole, David R., additional, Moritz, Michael L., additional, Nagami, Glenn T., additional, Padia, Shetal H., additional, Palmer, Biff F., additional, Patel, Tejas, additional, Pendse, Shona, additional, Portale, Anthony A., additional, Rainey, William E., additional, Ratcliffe, Peter J., additional, Reudelhuber, Timothy L., additional, Sands, Jeff M., additional, Schlanger, Lynn E., additional, Schrier, Robert W., additional, Semenza, Gregg L., additional, Singh, Ajay K., additional, Sica, Domenic A., additional, Simonson, Donald C., additional, Suneja, Manish, additional, Tait, James F., additional, Tiwari, Swasti, additional, and Trask, Aaron J., additional

Published
2009
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77. Contributors

Author

ABBATE, MAURO, primary, ABRAHAMSON, DALE R., additional, ADAMCZAK, MARCIN, additional, ADROGUÉ, HORACIO J., additional, ALPER, SETH L., additional, ALPERN, ROBERT J., additional, ANDREOLI, THOMAS E., additional, APERIA, ANITA C., additional, BAILEY, MATTHEW A., additional, BATLLE, DANIEL, additional, BAUM, MICHEL, additional, BERNDT, THERESA J., additional, BEVENSEE, MARK O., additional, BIBER, JÜRG, additional, BICHET, DANIEL G., additional, BINDELS, RENÉ J.M., additional, BLANTZ, ROLAND C., additional, BORON, WALTER F., additional, BRATER, D. CRAIG, additional, BRIGGS, JOSEPHINE P., additional, BROWN, ALEX, additional, BRUNSKILL, NIGEL J., additional, BURCKHARDT, GERHARD, additional, BURNSTOCK, GEOFFREY, additional, CANTLEY, LLOYD, additional, CAO, CHUNHUA, additional, CAPASSO, GIOVAMBATTISTA, additional, CAPLAN, MICHAEL J., additional, CARROLL, HUGH J., additional, CHAN, LAURENCE, additional, CHUNG-PARK, MOONJA, additional, COE, FREDRIC L., additional, COFFMAN, THOMAS M., additional, COMPER, WAYNE D., additional, CONRAD, KIRK P., additional, CROWLEY, STEVEN D., additional, CURTHOYS, NORMAN P., additional, CUTILLAS, PEDRO R., additional, DANOFF, THEODORE M., additional, DEBNAM, EDWARD S., additional, DIMKE, HENRIK, additional, DOUCET, ALAIN, additional, DUBEY, RAGHVENDRA K., additional, DUSSO, ADRIANA, additional, ECKARDT, KAI-UWE, additional, ELLISON, DAVID H., additional, ENDOU, HITOSHI, additional, ENDRE, ZOLTÁN HUBA, additional, EPSTEIN, FRANKLIN H., additional, EVAN, ANDREW, additional, FALK, RONALD J., additional, FARBAKHSH, KAMBIZ, additional, FERRERI, NICHOLAS R., additional, FONG, PEYING, additional, FONTELES, MANASSES CLAUDINO, additional, FORSTER, IAN, additional, FORTE, LEONARD RALPH, additional, FRANCH, HAROLD A., additional, FRASSETTO, LYNDA A., additional, FRIEDMAN, PETER A., additional, FRØKLÆR, JØRGEN, additional, GEIBEL, JOHN P., additional, GEKLE, MICHAEL, additional, GIEBISCH, GERHARD, additional, GINÈS, PERE, additional, GOLDSTEIN, STEVE A.N., additional, GORAL, SIMIN, additional, GRIFFIN, SIAN V., additional, GUGGINO, WILLIAM B., additional, GUISE, THERESA A., additional, GURLEY, SUSAN B., additional, HALL, STEPHEN D., additional, HALPERIN, MITCHELL L., additional, HAMM, L. LEE, additional, HEBERT, STEVEN C., additional, HEDIGER, MATTHIAS A., additional, HELDERMAN, J. HAROLD, additional, HENRICH, WILLIAM L., additional, HERAS-HERZIG, AILLEEN, additional, HERNANDO, NATI, additional, HOENDEROP, JOOST G.J., additional, HOLTBÄCK, ULLA, additional, HORISBERGER, JEAN-DANIEL, additional, HUMMLER, EDITH, additional, HUNLEY, TRACY E., additional, JACKSON, EDWIN K., additional, JENNETTE, J. CHARLES, additional, JOHNS, EDWARD J., additional, JOHNSON, JOHN P., additional, KAISSLING, BRIGITTE, additional, KAMEL, KAMEL S., additional, KARUMANCHI, S. ANANTH, additional, KASHTAN, CLIFFORD E., additional, KASISKE, BERTRAM L., additional, KATZ, ADRIAN I., additional, KING, BRIAN F., additional, KLAHR, SAULO, additional, KLEYMAN, THOMAS R., additional, KOEPSELL, HERMANN, additional, KON, VALENTINA, additional, KONRAD, MARTIN, additional, KOPP, ULLA C., additional, KRAPF, RETO, additional, KRIZ, WILHELM, additional, KUMAR, RAJIV, additional, KURSCHAT, CHRISTINE E., additional, KURTZ, ARMIN, additional, KWON, TAE-HWAN, additional, LANDOWSKI, CHRISTOPHER P., additional, LANGONE, ANTHONY J., additional, LANG, FLORIAN, additional, LAYTON, HAROLD E., additional, LE, THU H., additional, LEVY, DANIEL I., additional, LIN, SHIH-HUA, additional, LINDHEIMER, MARSHALL D., additional, LU, CHRISTOPHER Y., additional, MADAIO, MICHAEL P., additional, MADIAS, NICOLAOS E., additional, MALNIC, GERHARD, additional, MATLIN, KARL S., additional, McCLELLAN, WILLIAM C., additional, MCGIFF, JOHN C., additional, MICHEL, C. CHARLES, additional, MINER, JEFFREY H., additional, MITCH, WILLIAM E., additional, MIYAZAKI, HIROKI, additional, MOE, ORSON W., additional, MOLITORIS, BRUCE A., additional, MORRIS, R. CURTIS, additional, MUJAIS, SALIM K., additional, MURER, HEINI, additional, MUTO, SHIGEAKI, additional, NATTIE, EUGENE, additional, NEILSON, ERIC G., additional, NIELSEN, SØREN, additional, NIGAM, SANJAY K., additional, NOGUEIRA, JOSEPH M., additional, OH, MAN S., additional, OKUSA, MARK D., additional, OSICKA, TANYA M., additional, PALLONE, THOMAS L., additional, PALMER, BIFF F., additional, PALMER, LAWRENCE G., additional, PARKER, MARK D., additional, PARKS, JOAN H., additional, PREISIG, PATRICIA A., additional, QUAMME, GARY A., additional, QUARLES, L. DARRYL, additional, QUIGLEY, RAYMOND, additional, REEVES, W. BRIAN, additional, REMUZZI, GIUSEPPE, additional, REUSS, LUIS, additional, RICCARDI, DANIELA, additional, RINGHOFER, BRIAN, additional, RITZ, EBERHARD, additional, RIVARD, CHRISTOPHER J., additional, ROBERTSON, GARY L., additional, ROSA, ROBERT M., additional, ROSSIER, BERNARD C., additional, RUSSO, LEILEATA M., additional, SACKIN, HENRY, additional, SAKURAI, HIROYUKI, additional, SANDS, JEFF M., additional, SATLIN, LISA M., additional, SCHAEFER, HEIDI, additional, SCHELLING, JEFFREY R., additional, SCHILD, LAURENT, additional, SCHLINGMANN, KARL P., additional, SCHNERMANN, JÜRGEN B., additional, SCHRIER, ROBERT W., additional, SEBASTIAN, ANTHONY, additional, SEDOR, JOHN R., additional, SEGAL, YOAV, additional, SEKINE, TAKASHI, additional, SELDIN, DONALD W., additional, SENITKO, MARTIN, additional, SHAH, MALATHI, additional, SHAH, SUDHIR V., additional, SHANKLAND, STUART J., additional, SHARFUDDIN, ASIF A., additional, SHARMA, KUMAR, additional, SHENG, SHAOHU, additional, SHIRLEY, DAVID G., additional, SILBERNAGL, STEFAN, additional, SILVER, STEPHEN M., additional, SILVERMAN, MEL, additional, SLATOPOLSKY, EDUARDO, additional, SOMLO, STEFAN, additional, STERNS, RICHARD H., additional, STEWART, ANDREW K., additional, SUZUKI, YOSHIRO, additional, TEBBEN, PETER J., additional, THOMSON, SCOTT C., additional, TORRES, VICENTE E., additional, UNWIN, ROBERT J., additional, VERREY, FRANÇOIS, additional, VESELY, DAVID L., additional, WAGNER, CARSTEN A., additional, WALDMAN, MERYL, additional, WALKER, ROBERT JAMES, additional, WANG, WEI, additional, WANG, WEN-HUI, additional, WANG, YINGHONG, additional, WEINSTEIN, ALAN M., additional, WELLING, PAUL A., additional, WOLF, GUNTER, additional, WORCESTER, ELAINE, additional, ZIYADEH, FUAD N., additional, and ZOJA, CARLA, additional

Published
2008
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78. Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial

Author

Blair, John E.A., Pang, Peter S., Schrier, Robert W., Metra, Marco, Traver, Brian, Cook, Thomas, Campia, Umberto, Ambrosy, Andrew, Burnett, John C., Jr, Grinfeld, Liliana, Maggioni, Aldo P., Swedberg, Karl, Udelson, James E., Zannad, Faiez, Konstam, Marvin A., and Gheorghiade, Mihai

Published
2011
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98. Hormones and hemodynamics in heart failure

Author

Schrier, Robert W. and Abraham, William T.

Subjects
Heart failure -- Physiological aspects
Abstract

Research has shed much light on the cause of heart failure. As the heart begins to fail, it cannot pump as much blood as before. There are cells inside arteries that can detect low blood flow through the artery. These cells trigger several mechanisms to maintain adequate blood flow to other organs. However, these mechanisms may have a negative side, causing fluid to accumulate in various tissues, as well as other effects. For this reason, doctors often use ACE inhibitors and beta blockers in addition to diuretics to treat heart failure.

Published
1999

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