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2,652 results on '"Schreiber, Martin A."'

53. An Emulation Layer for Dynamic Resources with MPI Sessions

Author

Fecht, Jan, Schreiber, Martin, Schulz, Martin, Pritchard, Howard, Holmes, Daniel J., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Anzt, Hartwig, editor, Bienz, Amanda, editor, Luszczek, Piotr, editor, and Baboulin, Marc, editor

Published
2022
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56. A Parallel Time-Integrator for Solving the Linearized Shallow Water Equations on the Rotating Sphere

Author

Schreiber, Martin and Loft, Richard

Subjects
Physics - Computational Physics, Computer Science - Performance
Abstract

With the stagnation of processor core performance, further reductions in the time-to-solution for geophysical fluid problems are becoming increasingly difficult with standard time integrators. Parallel-in-time exposes and exploits additional parallelism in the time dimension which is inherently sequential in traditional methods. The rational approximation of exponential integrators (REXI) method allows taking arbitrarily long time steps based on a sum over a number of decoupled complex PDEs that can be solved independently massively parallel. Hence REXI is assumed to be well suited for modern massively parallel super computers which are currently trending. To date the study and development of the REXI approach has been limited to linearized problems on the periodic 2D plane. This work extends the REXI time stepping method to the linear shallow-water equations (SWE) on the rotating sphere, thus moving the method one step closer to solving fully nonlinear fluid problems of geophysical interest on the sphere. The rotating sphere poses particular challenges for finding an efficient solver due to the zonal dependence of the Coriolis term. Here we present an efficient REXI solver based on spherical harmonics, showing the results of: a geostrophic balance test, a comparison with alternative time stepping methods, an analysis of dispersion relations, indicating superior properties of REXI, and finally a performance comparison on Cheyenne supercomputer. Our results indicate that REXI is not only able to take larger time steps, but that REXI can also be used to gain higher accuracy and significantly reduced time-to-solution compared to currently existing time stepping methods.

Published
2018
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57. Multi-Level Spectral Deferred Corrections Scheme for the Shallow Water Equations on the Rotating Sphere

Author

Hamon, Francois, Schreiber, Martin, and Minion, Michael

Subjects
Mathematics - Numerical Analysis
Abstract

Efficient time integration schemes are necessary to capture the complex processes involved in atmospheric flows over long periods of time. In this work, we propose a high-order, implicit-explicit numerical scheme that combines Multi-Level Spectral Deferred Corrections (MLSDC) and the Spherical Harmonics (SH) transform to solve the wave-propagation problems arising from the shallow-water equations on the rotating sphere. The iterative temporal integration is based on a sequence of corrections distributed on coupled space-time levels to perform a significant portion of the calculations on a coarse representation of the problem and hence to reduce the time-to-solution while preserving accuracy. In our scheme, referred to as MLSDC-SH, the spatial discretization plays a key role in the efficiency of MLSDC, since the SH basis allows for consistent transfer functions between space-time levels that preserve important physical properties of the solution. We study the performance of the MLSDC-SH scheme with shallow-water test cases commonly used in numerical atmospheric modeling. We use this suite of test cases, which gradually adds more complexity to the nonlinear system of governing partial differential equations, to perform a detailed analysis of the convergence rate of MLSDC-SH upon refinement in time. We illustrate the good stability properties of MLSDC-SH and show that the proposed scheme achieves up to eighth-order accuracy in time. Finally, we study the conditions in which MLSDC-SH achieves its theoretical speedup, and we show that it can significantly reduce the computational cost compared to single-level Spectral Deferred Corrections (SDC).

Published
2018
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58. Exponential Integrators with Parallel-in-Time Rational Approximations for the Shallow-Water Equations on the Rotating Sphere

Author

Schreiber, Martin, Schaeffer, Nathanaël, and Loft, Richard

Subjects
Computer Science - Numerical Analysis, Computer Science - Computational Engineering, Finance, and Science
Abstract

High-performance computing trends towards many-core systems are expected to continue over the next decade. As a result, parallel-in-time methods, mathematical formulations which exploit additional degrees of parallelism in the time dimension, have gained increasing interest in recent years. In this work we study a massively parallel rational approximation of exponential integrators (REXI). This method replaces a time integration of stiff linear oscillatory and diffusive systems by the sum of the solutions of many decoupled systems, which can be solved in parallel. Previous numerical studies showed that this reformulation allows taking arbitrarily long time steps for the linear oscillatory parts. The present work studies the non-linear shallow-water equations on the rotating sphere, a simplified system of equations used to study properties of space and time discretization methods in the context of atmospheric simulations. After introducing time integrators, we first compare the time step sizes to the errors in the simulation, discussing pros and cons of different formulations of REXI. Here, REXI already shows superior properties compared to explicit and implicit time stepping methods. Additionally, we present wallclock-time-to-error results revealing the sweet spots of REXI obtaining either an over 6x higher accuracy within the same time frame or an about 3x reduced time-to-solution for a similar error threshold. Our results motivate further explorations of REXI for operational weather/climate systems.

Published
2018

59. Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production

Author

Trivedi, Alpa, Miyazawa, Byron, Gibb, Stuart, Valanoski, Kristen, Vivona, Lindsay, Lin, Maximillian, Potter, Daniel, Stone, Mars, Norris, Philip J, Murphy, James, Smith, Sawyer, Schreiber, Martin, and Pati, Shibani

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Regenerative Medicine, Hematology, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research - Nonembryonic - Human, Clinical Research, Transplantation, Stem Cell Research, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Animals, Biomarkers, Bone Marrow Cells, Cell Culture Techniques, Cell Differentiation, Cell Lineage, Cell Proliferation, Cell Shape, Culture Media, Conditioned, Donor Selection, Electric Impedance, Endothelial Cells, Female, Humans, Immunophenotyping, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Swine, Stem cell therapy, Bioprocessing, Viability, Differentiation, Donor variability, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundCell based therapies, such as bone marrow derived mesenchymal stem cells (BM-MSCs; also known as mesenchymal stromal cells), are currently under investigation for a number of disease applications. The current challenge facing the field is maintaining the consistency and quality of cells especially for cell dose production for pre-clinical testing and clinical trials. Here we determine how BM-donor variability and thus the derived MSCs factor into selection of the optimal primary cell lineage for cell production and testing in a pre-clinical swine model of trauma induced acute respiratory distress syndrome.MethodsWe harvested bone marrow and generated three different primary BM-MSCs from Yorkshire swine. Cells from these three donors were characterized based on (a) phenotype (morphology, differentiation capacity and flow cytometry), (b) in vitro growth kinetics and metabolic activity, and (c) functional analysis based on inhibition of lung endothelial cell permeability.ResultsCells from each swine donor exhibited varied morphology, growth rate, and doubling times. All expressed the same magnitude of standard MSC cell surface markers by flow cytometry and had similar differentiation potential. Metabolic activity and growth potential at each of the passages varied between the three primary cell cultures. More importantly, the functional potency of the MSCs on inhibition of endothelial permeability was also cell donor dependent.ConclusionThis study suggests that for production of MSCs for cell-based therapy, it is imperative to examine donor variability and characterize derived MSCs for marker expression, growth and differentiation characteristics and testing potency in application dependent assays prior to selection of the optimal cell lineage for large scale expansion and dose production.

Published
2019

60. Serum albumin and hospitalization among pediatric patients with end-stage renal disease who started dialysis therapy

Author

Okuda, Yusuke, Obi, Yoshitsugu, Streja, Elani, Laster, Marciana, Rhee, Connie, Langman, Craig B, Jernigan, Stephanie M, Salusky, Isidro B, Tentori, Francesca, Schreiber, Martin J, Brunelli, Steven M, and Kalantar-Zadeh, Kamyar

Subjects
Kidney Disease, Clinical Research, Renal and urogenital, Zero Hunger, Adolescent, Child, Child, Preschool, Energy Metabolism, Female, Hospitalization, Humans, Hypoalbuminemia, Infant, Kidney Failure, Chronic, Male, Renal Dialysis, Retrospective Studies, Serum Albumin, Hyperalbuminemia, Protein energy wasting, Incident dialysis patients, Paediatrics and Reproductive Medicine, Urology & Nephrology
Abstract

BackgroundHypoalbuminemia is a strong predictor of hospitalization and mortality among adult dialysis patients. However, data are scant on the association between serum albumin and hospitalization among children new to dialysis.MethodsIn a retrospective cohort study of children 1-17 years old with end-stage renal disease receiving dialysis therapy in a large US dialysis organization 2007-2011, we examined the association of serum albumin with hospitalization frequency and total hospitalization days using a negative binomial regression model.ResultsAmong 416 eligible patients, median (interquartile range) age was 14 (10-16) years and mean ± SD baseline serum albumin level was 3.7 ± 0.8 g/dL. Two hundred sixty-six patients (64%) were hospitalized during follow-up with an incidence rate of 2.2 (95%CI, 1.9-2.4) admissions per patient-year. There was a U-shaped association between serum albumin and hospitalization frequency; hospitalization rates (95%CI) were 2.7 (2.2-3.2), 1.9 (1.5-2.4), 1.6 (1.3-1.9), and 2.7 (1.7-3.6) per patient-year among patients with serum albumin levels

Published
2019

61. Regulation of Endothelial Cell Permeability by Platelet-Derived Extracellular Vesicles

Author

Miyazawa, Byron, Trivedi, Alpa, Togarrati, Padma Priya, Potter, Daniel, Baimukanova, Gyulnar, Vivona, Lindsay, Lin, Maximillian, Lopez, Ernesto, Callcut, Rachael, Srivastava, Amit K, Kornblith, Lucy Z, Fields, Alexander T, Schreiber, Martin A, Wade, Charles E, Holcomb, John B, and Pati, Shibani

Subjects
Hematology, Clinical Research, Cardiovascular, Analysis of Variance, Animals, Blood Platelets, Capillary Permeability, Extracellular Vesicles, Hemostasis, Humans, Mice, Vascular instability, trauma, barrier disruption, hemostasis, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Nursing, Emergency & Critical Care Medicine
Abstract

BACKGROUND:Platelet (Plt) derived-extracellular vesicles (Plt-EVs) have hemostatic properties similar to Plts. In addition to hemostasis, Plts also function to stabilize the vasculature and maintain endothelial cell (EC) barrier integrity. We hypothesized that Plt-EVs would inhibit vascular endothelial cell permeability, similar to fresh Plts. To investigate this hypothesis we utilized in vitro and in vivo models of vascular endothelial compromise and bleeding. METHODS:In vitro: Plt-EVs were isolated by ultracentrifugation and characterized for Plt markers and particle size distribution. Effects of Plts and Plt-EVs on endothelial barrier function was assessed by trans - endothelial electrical resistance (TEER) measurements and histological analysis of endothelial junction proteins. Hemostatic potential of Plt-EVs and Plts were assessed by multiple electrode Plt aggregometry. In vivo: The effects of Plts and Plt-EVs on vascular permeability and bleeding were assessed in NOD-SCID mice by an established Miles Assay of vascular permeability and a tail snip bleeding assay. RESULTS:In vitro: Plt-EVs displayed exosomal size distribution and expressed Plt specific surface markers. Plts and Plt-EVs decreased EC permeability and restored EC junctions after thrombin challenge. Multiplate aggregometry revealed that Plt-EVs enhanced Thrombin Receptor Activating Peptide (TRAP) mediated aggregation of whole blood, whereas Plts enhanced TRAP, Arachidonic Acid (ASPI), Collagen, and Adenosine Diphosphate (ADP) mediated aggregation. In vivo: Plt-EVs are equivalent to Plts in attenuating VEGF-A induced vascular permeability and uncontrolled blood loss in a tail snip hemorrhage model. CONCLUSION:Our study is the first to report that Plt-EVs might provide a feasible product for transfusion in trauma patients to attenuate bleeding, inhibit vascular permeability and mitigate the endotheliopathy of trauma (EOT). STUDY TYPE:Original Article LEVEL OF EVIDENCE: This is a pre-clinical study so it does not confirm to the level of evidence table for all clinical studies and case reports.

Published
2019

62. TEG Lysis Shutdown Represents Coagulopathy in Bleeding Trauma Patients

Author

Cardenas, Jessica C, Wade, Charles E, Cotton, Bryan A, George, Mitchell J, Holcomb, John B, Schreiber, Martin A, and White, Nathan J

Subjects
Clinical Research, Physical Injury - Accidents and Adverse Effects, Hematology, Adult, Female, Fibrinogen, Fibrinolysis, Hemorrhage, Humans, Male, Middle Aged, Plasminogen Activator Inhibitor 1, Retrospective Studies, Thrombelastography, Thrombophilia, alpha-2-Antiplasmin, Coagulopathy, fibrinolysis, shutdown, thrombelastography, trauma, PROPPR Study Group, Clinical Sciences, Emergency & Critical Care Medicine
Abstract

BACKGROUND:Thrombelastography (TEG) fibrinolysis shutdown after trauma is associated with increased mortality due to hypercoagulability-associated organ failure. However, a lack of mechanistic data has precluded the development of novel interventions to treat shutdown. OBJECTIVES:To define the pathophysiology of TEG shutdown in severely injured, bleeding patients through secondary analysis of the PROPPR trial. METHODS:Fibrinolysis was characterized in PROPPR subjects using admission TEG lysis at 30 min (LY30) or plasmin-antiplasmin (PAP) levels. LY30 categories were low (20,000 μg/L). Demographics, outcomes, admission TEG values, platelet count and function, standard coagulation tests, and coagulation proteins were compared. RESULTS:Five hundred forty-seven patients had TEG data and 549 patients had PAP data available. Low LY30 was associated with reduced platelet count and aggregation, poorer TEG clot formation, prolonged clotting times, and reduced fibrinogen and alpha2 antiplasmin. Compared to moderate PAP, low PAP subjects had similar platelet parameters, TEG values, fibrinogen, and alpha2 antiplasmin, but reduced tPA, and elevated PAI-1. D-Dimer values increased as PAP increased, however patients with low LY30 had elevated D-Dimer compared with moderate LY30 patients. Most low LY30 deaths were due to TBI (45%) and hemorrhage (42%) versus one of each cause (TBI, hemorrhage, MOF) in low PAP patients. CONCLUSIONS:Low TEG LY30 does not reflect shutdown of enzymatic fibrinolysis with hypercoagulability, but rather a coagulopathic state of moderate fibrinolysis with fibrinogen consumption and platelet dysfunction that is associated with poor outcomes.

Published
2019

63. Access to trauma center care: A statewide system-based approach

Author

Medrano, Nicolas W., Villarreal, Cynthia Lizette, Price, Michelle A., Bixby, Pamela J., Bulger, Eileen M., Eastridge, Brian J., Albrecht, Roxie M., Bailey, Jeffrey A., Benjamin, Elizabeth R., Bernard, Andrew C., Blackwell, Thomas H., Braithwaite, Sabina A., Brasel, Karen J., Brice, Jane H., Burlew, Clay C., Butler, Frank K., Callaway, David W., Cannon, Jeremy W., Champion, Howard R., Chang, Michael, Coimbra, Raul S., Davis, Gregory G., Demarest, Gerald B., Dorlac, Warren C., Drake, Stacy A., Eastman, Alex L., Elster, Eric A., Epley, Eric, Esposito, Thomas J., Ficke, James R., Fisher, Andrew D., Fowler, David R., Gaines, Barbara A., Gallagher, John M., Gary, Joshua L., Gestring, Mark L., Gill, James R., Goodloe, Jeffrey M., Gurney, Jennifer M., Harrell, Andrew J., Henry, Sharon M., Holcomb, John B., Jenkins, Donald H., Johannigman, Jay A., Kerby, Jeffrey D., Kharod, Chetan U., Kotwal, Russ S., Kozar, Rosemary A., Kuhls, Deborah A., Lathrop, Sarah L., Latimer, Andrew J., Levy, Michael, Mabry, Robert L., MacKenzie, Ellen J., Martin, Matthew J., Maxson, R. Todd, Mazuchowski, Edward L., Minei, Joseph P., Mitchell, Roger A., Jr, Moore, Ernest E., Moores, Leon E., Nashelsky, Marcus B., Nathens, Avery B., Nolte, Kurt B., OʼKeefe, Grant E., Phillips, Monica J., Robinson, James L., Sagraves, Scott G., Scalea, Thomas M., Schenarts, Paul J., Schreiber, Martin A., Shackelford, Stacy A., Sperry, Jason L., Stassen, Nicole A., Staudenmayer, Kristan L., Stewart, Ronald M., Stuke, Lance E., Valadka, Alex B., Winchell, Robert J., Zonies, David, and Yelon, Jay A.

Published
2023
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64. Committee on Surgical Combat Casualty Care position statement: Neurosurgical capability for the optimal management of traumatic brain injury during deployed operations

Author

Gurney, Jennifer M., Tadlock, Matthew D., Dengler, Bradley A., Gavitt, Brian J., Dirks, Michael S., Holcomb, John B., Kotwal, Russ S., Benavides, Linda C., Cannon, Jeremy W., Edson, Theodore, Graybill, John C., Sonka, Brian J., Marion, Donald W., Eckert, Matthew J., Schreiber, Martin A., Polk, Travis M., Jensen, Shane D., Martin, Matthew J., Joseph, Bellal A., Valadka, Alex, and Kerby, Jeffrey D.

Published
2023
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67. Outcomes Among Trauma Patients with Duodenal Leak Following Primary vs Complex Repair of Duodenal Injuries: An EAST Multicenter Trial

Author

Choron, Rachel L., Teichman, Amanda, Bargoud, Christopher, Sciarretta, Jason D., Smith, Randi, Hanos, Dustin, Afif, Iman N., Beard, Jessica H., Dhillon, Navpreet K., Zhang, Ashling, Ghneim, Mira, Devasahayam, Rebekah J., Gunter, Oliver L., Jr, Smith, Alison A., Sun, Brandi, Cao, Chloe S., Reynolds, Jessica K., Hilt, Lauren A, Holena, Daniel N., Chang, Grace, Jonikas, Meghan, Echeverria-Rosario, Karla, Fung, Nathaniel S., Anderson, Aaron, Dumas, Ryan P., Fitzgerald, Caitlin A., Levin, Jeremy H., Trankiem, Christine T., Yoon, JaeHee, Blank, Jacqueline, Hazelton, Joshua P., McLaughlin, Christopher J., Al-Aref, Rami, Kirsch, Jordan M., Howard, Daniel S., Scantling, Dane R., Dellonte, Kate, Vella, Michael, Hopkins, Brent, Shell, Chloe, Udekwu, Pascal O., Wong, Evan G, Joseph, Bellal, Lieberman, Howard, Ramsey, Walter A, Stewart, Collin H., Alvarez, Claudia, Berne, John D., Nahmias, Jeffry, Puente, Ivan, Patton, Joe H., Jr., Rakitin, Ilya, Perea, Lindsey, Pulido, Odessa, Ahmed, Hashim, Keating, Jane, Kodadek, Lisa M., Wade, Jason, Henry, Reynold, Schreiber, Martin A., Benjamin, Andrew J., Khan, Abid, Mann, Laura K., Mentzer, Caleb J., Mousafeiris, Vasileios, Mulita, Francesk, Reid-Gruner, Shari, Sais, Erica, Foote, Christopher, Palacio, Carlos H, Argandykov, Dias, Kaafarani, Haytham, Coyle, Susette, Macor, Marie, Bover Manderski, Michelle T., Narayan, Mayur, and Seamon, Mark J.

Published
2023
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68. Personalized approach for complex bilateral calcaneal osteomyelitis and defect reconstruction with bilateral abductor digiti minimi flaps

Author

Grigorescu Oana, Dragu Adrian, Bönke Florian, Schreiber Martin, and Rammelt Stefan

Subjects
abductor digiti minimi muscle flap, calcaneal osteomyelitis, personalized approach, Surgery, RD1-811
Abstract

The best treatment for displaced, intra-articular fractures of the calcaneus remains controversial and it is generally agreed, that there is no single method that is suitable for all patients.

Published
2022
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69. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Author

Whelton, Paul, Johnson, Karen C., Snyder, Joni, Bild, Diane, Bonds, Denise, Cook, Nakela, Cutler, Jeffrey, Fine, Lawrence, Kaufmann, Peter, Kimmel, Paul, Launer, Lenore, Moy, Claudia, Riley, William, Ryan, Laurie, Tolunay, Eser, Yang, Song, Reboussin, David, Williamson, Jeff, Ambrosius, Walter T., Applegate, William, Evans, Greg, Foy, Capri, Freedman, Barry I., Kitzman, Dalane, Lyles, Mary, Pajewski, Nick, Rapp, Steve, Rushing, Scott, Shah, Neel, Sink, Kaycee M., Vitolins, Mara, Wagenknecht, Lynne, Wilson, Valerie, Perdue, Letitia, Woolard, Nancy, Craven, Tim, Garcia, Katelyn, Gaussoin, Sarah, Lovato, Laura, Newman, Jill, Lovato, James, Lu, Lingyi, McLouth, Chris, Russell, Greg, Amoroso, Bobby, Davis, Patty, Griffin, Jason, Harris, Darrin, King, Mark, Lane, Kathy, Roberson, Wes, Steinberg, Debbie, Ashford, Donna, Babcock, Phyllis, Chamberlain, Dana, Christensen, Vickie, Cloud, Loretta, Collins, Christy, Cook, Delilah, Currie, Katherine, Felton, Debbie, Harpe, Stacy, Howard, Marjorie, Lewis, Michelle, Nance, Pamela, Puccinelli-Ortega, Nicole, Russell, Laurie, Walker, Jennifer, Craven, Brenda, Goode, Candace, Troxler, Margie, Davis, Janet, Hutchens, Sarah, Killeen, Anthony A., Lukkari, Anna M., Ringer, Robert, Dillard, Brandi, Archibeque, Norbert, Warren, Stuart, Sather, Mike, Pontzer, James, Taylor, Zach, Soliman, Elsayed Z., Zhang, Zhu-Ming, Li, Yabing, Campbell, Chuck, Hensley, Susan, Hu, Julie, Keasler, Lisa, Barr, Mary, Taylor, Tonya, Bryan, R. Nick, Davatzikos, Christos, Nasarallah, Ilya, Desiderio, Lisa, Elliott, Mark, Borthakur, Ari, Battapady, Harsha, Erus, Guray, Smith, Alex, Wang, Ze, Doshi, Jimit, Wright, Jackson T., Jr., Rahman, Mahboob, Lerner, Alan J., Still, Carolyn, Wiggers, Alan, Zamanian, Sara, Bee, Alberta, Dancie, Renee, Thomas, George, Schreiber, Martin, Jr., Navaneethan, Sankar Dass, Hickner, John, Lioudis, Michael, Lard, Michelle, Marczewski, Susan, Maraschky, Jennifer, Colman, Martha, Aaby, Andrea, Payne, Stacey, Ramos, Melanie, Horner, Carol, Drawz, Paul, Raghavendra, Pratibha P., Ober, Scott, Mourad, Ronda, Pallaki, Muralidhar, Russo, Peter, Raghavendra, Pratibha, Fantauzzo, Pual, Tucker, Lisa, Schwing, Bill, Sedor, John R., Horwitz, Edward J., Schellling, Jeffrey R., O’Toole, John F., Humbert, Lisa, Tutolo, Wendy, White, Suzanne, Gay, Alishea, Clark, Walter, Jr., Hughes, Robin, Dobre, Mirela, Still, Carolyn H., Williams, Monique, Bhatt, Udayan, Hebert, Lee, Agarwal, Anil, Murphy, Melissa Brown, Ford, Nicole, Stratton, Cynthia, Baxter, Jody, Lykins, Alicia A., McKinley Neal Leena Hirmath, Alison, Kwame, Osei, Soe, Kyaw, Miser, William F., Sagrilla, Colleen, Johnston, Jan, Anaya, Amber, Mintos, Ashley, Howell, Angel A., Rogers, Kelly, Taylor, Sara, Ebersbacher, Donald, Long, Lucy, Bednarchik, Beth, Schnall, Adrian, Smith, Jonathan, Peysha, Lori, Leach, Lisa, Tribout, Megan, Harwell, Carla, Ellington, Pinkie, Banerji, Mary Ann, Ghody, Pranav, Rambaud, Melissa Vahídeh, Townsend, Raymond, Cohen, Debbie, Huan, Yonghong, Duckworth, Mark, Ford, Virginia, Leshner, Juliet, Davison, Ann, Veen, Sarah Vander, Gadegbeku, Crystal A., Gillespie, Avi, Paranjape, Anuradha, Amoroso, Sandra, Pfeffer, Zoe, Quinn, Sally B., He, Jiang, Chen, Jing, Lustigova, Eva, Malone, Erin, Krousel-Wood, Marie, Deichmann, Richard, Ronney, Patricia, Muery, Susan, Trapani, Donnalee, Rocco, Michael, Goff, David, Rodriguez, Carlos, Coker, Laura, Hawfield, Amret, Yeboah, Joseph, Crago, Lenore, Summerson, John, Hege, Anita, Diamond, Matt, Mulloy, Laura, Hodges, Marcela, Collins, Michelle, Weathers, Charlene, Anderson, Heather, Stone, Emily, Walker, Walida, McWilliams, Andrew, Dulin, Michael, Kuhn, Lindsay, Standridge, Susan, Lowe, Lindsay, Everett, Kelly, Preston, Kelry, Norton, Susan, Gaines, Silena, Rizvi, Ali A., Sides, Andrew W., Herbert, Diamond, Hix, Matthew M., Whitmire, Melanie, Arnold, Brittany, Hutchinson, Philip, Espiritu, Joseph, Feinglos, Mark, Kovalik, Eugene, Gedon-Lipscomb, Georgianne, Evans, Kathryn, Thacker, Connie, Zimmer, Ronna, Furst, Mary, Mason, MaryAnn, Powell, James, Bolin, Paul, Zhang, Junhong, Pinion, Mary, Davis, Gail, Bryant, Winifred, Phelps, Presley, Garris-Sutton, Connie, Atkinson, Beatrice, Contreras, Gabriele, Suarez, Maritza, Schulman, Ivonne, Koggan, Don, Vassallo, Jackie, Peruyera, Gloria, Whittington, Sheri, Bethea, Cassandra, Gilliam, Laura, Pedley, Carolyn, Zurek, Geraldine, Baird, Miriam, Herring, Charles, Smoak, Mary Martha, Williams, Julie, Rogers, Samantha, Gordon, Lindsay, Kennedy, Erin, Belle, Beverly, McCorkle-Doomy, Jessica, Adams, Jonathan, Lopez, Ramon, Janavs, Juris, Rahbari-Oskoui, Frederic, Chapman, Arlene, Dollar, Allen, Williams, Olubunmi, Han, Yoosun, Haley, William, Fitzpatrick, Peter, Blackshear, Joseph, Shapiro, Brian, Harrell, Anna, Palaj, Arta, Henderson, Katelyn, Johnson, Ashley, Gonzalez, Heath, Robinson, Jermaine, Tamariz, Leonardo, Denizard, Jennifer, Barakat, Rody, Krishnamoorthy, Dhurga, Greenway, Frank, Monce, Ron, Church, Timothy, Hendrick, Chelsea, Yoches, Aimee, Sones, Leighanne, Baltazar, Markee, Pemu, Priscilla, Jones, Connie, Akpalu, Derrick, Cheung, Alfred K., Beddhu, Srinivasan, Chelune, Gordon, Childs, Jeffrey, Gren, Lisa, Randall, Anne, Dember, Laura, Soares, Denise, Yee, Jerry, Umanath, Kausik, Ogletree, Naima, Thaxton, Schawana, Campana, Karen, Sheldon, Dayna, MacArthur, Krista, Muhlestein, J. Brent, Allred, Nathan, Clements, Brian, Dhar, Ritesh, Meredith, Kent, Le, Viet, Miner, Edward, Orford, James, Riessen, Erik R., Ballantyne, Becca, Chisum, Ben, Johnson, Kevin, Peeler, Dixie, Chertow, Glenn, Tamura, Manju, Chang, Tara, Erickson, Kevin, Shen, Jenny, Stafford, Randall S., Zaharchuk, Gregory, Del Cid, Margareth, Dentinger, Michelle, Sabino, Jennifer, Sahay, Rukmani, Telminova, Ekaterina, Weiner, Daniel E., Sarnak, Mark, Chan, Lily, Civiletto, Amanda, Heath, Alyson, Kantor, Amy, Jain, Priyanka, Kirkpatrick, Bethany, Well, Andrew, Yuen, Barry, Chonchol, Michel, Farmer, Beverly, Farmer, Heather, Greenwald, Carol, Malaczewski, Mikaela, Lash, James, Porter, Anna, Ricardo, Ana, Rosman, Robert T., Cohan, Janet, Barrera, Nieves Lopez, Meslar, Daniel, Meslar, Patricia, Conroy, Margaret, Unruh, Mark, Hess, Rachel, Jhamb, Manisha, Thomas, Holly, Fazio, Pam, Klixbull, Elle, Komlos-Weimer, Melissa, Mandich, LeeAnne, Vita, Tina, Toto, Robert, Van Buren, Peter, Inrig, Julia, Cruz, Martha, Lightfoot, Tammy, Wang, Nancy, Webster, Lori, Raphael, Kalani, Stults, Barry, Zaman, Tahir, Simmons, Debra, Lavasani, Tooran, Filipowicz, Rebecca, Wei, Guo, Miller, Gracie Mary, Harerra, Jenice, Christensen, Jeff, Giri, Ajay, Chen, Xiaorui, Anderton, Natalie, Jensen, Arianna, Lewis, Julia, Burgner, Anna, Dwyer, Jamie P., Schulman, Gerald, Herrud, Terri, Leavell, Ewanda, McCray, Tiffany, McNeil-Simaan, Edwina, Poudel, Munmun, Reed, Malia, Sika, Mohammed, Woods, Delia, Zirkenbach, Janice L., Raj, Dominic S., Cohen, Scott, Patel, Samir, Velasquez, Manuel, Bastian, Roshni S., Wing, Maria, Roy-Chaudhury, Akshay, Depner, Thomas, Dalyrymple, Lorien, Kaysen, George, Anderson, Susan, Nord, John, Ix, Joachim H., Goldenstein, Leonard, Miracle, Cynthia M., Forbang, Nketi, Mircic, Maja, Thomas, Brenda, Tran, Tiffany, Rastogi, Anjay, Kim, Mihae, Rashid, Mohamad, Lizarraga, Bianca, Hocza, Amy, Sarmosyan, Kristine, Norris, Jason, Sharma, Tushar, Chioy, Amanda, Bernard, Eric, Cabrera, Eleanore, Lopez, Christina, Nunez, Susana, Riad, Joseph, Schweitzer, Suzanne, Sirop, Siran, Thomas, Sarah, Wada, Lauren, Kramer, Holly, Bansal, Vinod, Taylor, Corliss E., Segal, Mark S., Hall, Karen L., Kazory, Amir, Gilbert, Lesa, Owens, Linda, Poulton, Danielle, Whidden, Elaine, Wiggins, Jocelyn, Blaum, Caroline, Nyquist, Linda, Min, Lillian, Gure, Tanya, Lewis, Ruth, Mawby, Jennifer, Robinson, Eileen, Oparil, Suzanne, Lewis, Cora E., Bradley, Virginia, Calhoun, David, Glasser, Stephen, Jenkins, Kim, Ramsey, Tom, Qureshi, Nauman, Ferguson, Karen, Haider, Sumrah, James, Mandy, Jones, Christy, Renfroe, Kim, Seay, April, Weigart, Carrie, Thornley-Brown, Denyse, Rizik, Dana, Cotton, Bari, Fitz-Gerald, Meredith, Grimes, Tiffany, Johnson, Carolyn, Kennedy, Sara, Mason, Chanel, Rosato-Burson, Lesa, Willingham, Robin, Judd, Eric, Breaux-Shropshire, Tonya, Cook, Felice, Medina, Julia, Ghazi, Lama, Bhatt, Hemal, Lewis, James, Brantley, Roman, Brouilette, John, Glaze, Jeffrey, Hall, Stephanie, Hiott, Nancy, Tharpe, David, Boddy, Spencer, Mack, Catherine, Womack, Catherine, Asao, Keiko, Griffin, Beate, Hendrix, Carol, Johnson, Karen, Jones, Lisa, Towers, Chelsea, Punzi, Henry, Cassidy, Kathy, Schumacher, Kristin, Irizarry, Carmen, Colon, Ilma, Colon-Ortiz, Pedro, Colón-Hernández, Pedro J., Carrasquillo-Navarro, Orlando J., Carrasquillo, Merari, Vazquez, Nivea, Sosa-Padilla, Miguel, Cintron-Pinero, Alex, Ayala, Mayra, Pacheco, Olga, Rivera, Catalina, Sotomayor-Gonzalez, Irma, Claudio, Jamie, Lazaro, Jose, Arce, Migdalia, Heres, Lourdes, Perez, Alba, Tavarez-Valle, Jose, Arocho, Ferlinda, Torres, Mercedes, Vazquez, Melvaliz, Aurigemma, Gerard P., Takis-Smith, Rebecca, Andrieni, Julia, Bodkin, Noelle, Chaudhary, Kiran, Hu, Paula, Kostis, John, Cosgrove, Nora, Bankowski, Denise, Boleyn, Monica, Casazza, Laurie, Giresi, Victoria, Patel, Tosha, Squindo, Erin, Wu, Yan, Henson, Zeb, Wofford, Marion, Lowery, Jessica, Minor, Deborah, Harkins, Kimberley, Auchus, Alexander, Flessner, Michael, Adair, Cathy, Asher, Jordan, Loope, Debbie, Cobb, Rita, Venegas, Reiner, Bigger, Thomas, Bello, Natalie, Homma, Shunichi, Donovan, Daniel, Lopez-Jimenez, Carlos, Tirado, Amilcar, Getaneh, Asqual, Tang, Rocky, Durant, Sabrina, Maurer, Mathew, Teruya, Sergio, Helmke, Stephen, Alvarez, Julissa, Campbell, Ruth, Pisoni, Roberto, Sturdivant, Rachel, Brooks, Deborah, Counts, Caroline, Hunt, Vickie, Spillers, Lori, Brautigam, Donald, Kitchen, Timothy, Gorman, Timothy, Sayers, Jessica, Button, Sarah, Chiarot, June, Fischer, Rosemary, Lyon, Melissa, Resnick, Maria, Hodges, Nicole, Ferreira, Jennifer, Cushman, William, Wall, Barry, Nichols, Linda, Burns, Robert, Martindale-Adams, Jennifer, Berlowitz, Dan, Clark, Elizabeth, Walsh, Sandy, Geraci, Terry, Huff, Carol, Shaw, Linda, Servilla, Karen, Vigil, Darlene, Barrett, Terry, Sweeney, Mary Ellen, Johnson, Rebecca, McConnell, Susan, Salles, Khadijeh Shahid, Watson, Francoise, Schenk, Cheryl, Whittington, Laura, Maher, Maxine, Williams, Jonathan, Swartz, Stephen, Conlin, Paul, Alexis, George, Lamkin, Rebecca, Underwood, Patti, Gomes, Helen, Rosendorff, Clive, Atlas, Stephen, Khan, Saadat, Gonzalez, Waddy, Barcham, Samih, Kwon, Lawrence, Matar, Matar, Adhami, Anwar, Basile, Jan, John, Joseph, Ham, Deborah, Baig, Hadi, Saklayen, Mohammed, Yap, Jason, Neff, Helen, Miller, Carol, Zheng-Phelan, Ling, Gappy, Saib, Rau, Shiva, Raman, Arathi, Berchou, Vicki, Jones, Elizabeth, Olgren, Erin, Marbury, Cynthia, Yudd, Michael, Sastrasinh, Sithiporn, Michaud, Jennine, Fiore, Jessica, Kutza, Marianne, Shorr, Ronald, Mount, Rattana, Dunn, Helen, Stinson, Susan, Hunter, Jessica, Taylor, Addison, Bates, Jeffery, Anderson, Catherine, Kirchner, Kent, Stubbs, Jodi, Hinton, Ardell, Spencer, Anita, Sharma, Santosh, Wiegmann, Thomas, Mehta, Smita, Krause, Michelle, Dishongh, Kate, Childress, Richard, Gyamlani, Geeta, Niakan, Atossa, Thompson, Cathy, Moody, Janelle, Gresham, Carolyn, Whittle, Jeffrey, Barnas, Gary, Wolfgram, Dawn, Cortese, Heidi, Johnson, Jonette, Roumie, Christianne, Hung, Adriana, Wharton, Jennifer, Niesner, Kurt, Katz, Lois, Richardson, Elizabeth, Brock, George, Holland, Joanne, Dixon, Troy, Zias, Athena, Spiller, Christine, Baker, Penelope, Felicetta, James, Rehman, Shakaib, Bingham, Kelli, Watnick, Suzanne, Cohen, David, Weiss, Jessica, Johnston, Tera, Giddings, Stephen, Yamout, Hala, Klein, Andrew, Rowe, Caroline, Vargo, Kristin, Waidmann, Kristi, Papademetriou, Vasilios, Elkhoury, Jean Pierre, Gregory, Barbara, Amodeo, Susan, Bloom, Mary, Goldfarb-Waysman, Dalia, Treger, Richard, Kashefi, Mehran, Huang, Christina, Knibloe, Karen, Ishani, Areef, Slinin, Yelena, Olney, Christine, Rust, Jacqueline, Fanti, Paolo, Dyer, Christopher, Bansal, Shweta, Dunnam, Monica, Hu, Lih-Lan, Zarate-Abbott, Perla, Kurella Tamura, Manjula, Pajewski, Nicholas M., Zaharchuk, Greg, Rapp, Stephen R., Auchus, Alexander P., Haley, William E., Kendrick, Jessica, Roumie, Christianne L., Williamson, Jeff D., Detre, John A., Dolui, Sudipto, and Nasrallah, Ilya M.

Published
2022
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70. Outcomes among trauma patients with duodenal leak following primary versus complex repair of duodenal injuries: An Eastern Association for the Surgery of Trauma multicenter trial

Author

Choron, Rachel L., Teichman, Amanda L., Bargoud, Christopher G., Sciarretta, Jason D., Smith, Randi N., Hanos, Dustin S., Afif, Iman N., Beard, Jessica H., Dhillon, Navpreet K., Zhang, Ashling, Ghneim, Mira, Devasahayam, Rebekah J., Gunter, Oliver L., Smith, Alison A, Sun, Brandi L., Cao, Chloe S., Reynolds, Jessica K., Hilt, Lauren A., Holena, Daniel N., Chang, Grace, Jonikas, Meghan, Echeverria, Karla, Fung, Nathaniel S., Anderson, Aaron, Fitzgerald, Caitlin A., Dumas, Ryan P., Levin, Jeremy H., Trankiem, Christine T., Yoon, JaeHee Jane, Blank, Jacqueline, Hazelton, Joshua, McLaughlin, Christopher J., Al-Aref, Rami, Kirsch, Jordan M., Howard, Daniel S., Scantling, Dane R., Dellonte, Kate, Vella, Michael, Hopkins, Brent, Shell, Chloe H., Udekwu, Pascal O., Wong, Evan G., Joseph, Bellal A., Lieberman, Howard, Ramsey, Walter, Stewart, Collin, Alvarez, Claudia, Berne, John D., Nahmias, Jeffry, Puente, Ivan, Patton, Joe H., Jr, Rakitin, Ilya, Perea, Lindsey L., Pulido, Odessa R., Ahmed, Hashim, Keating, Jane, Kodadek, Lisa M., Wade, Jason, Henry, Reynold, Schreiber, Martin A., Benjamin, Andrew J., Khan, Abid, Mann, Laura K., Mentzer, Caleb J., Mousafeiris, Vasileios, Mulita, Francesk, Reid-Gruner, Shari, Sais, Erica, Marks, Joshua, Foote, Christopher, Palacio, Carlos H., Argandykov, Dias, Kaafarani, Haytham, Coyle, Susette, Macor, Marie, Manderski, Michelle T. Bover, Narayan, Mayur, and Seamon, Mark J.

Published
2023
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71. Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study

Author

Gelbard, Rondi B., Nahmias, Jeffry, Byerly, Saskya, Ziesmann, Markus, Stein, Deborah, Haut, Elliott R., Smith, Jason W., Boltz, Melissa, Zarzaur, Ben, Callum, Jeannie, Cotton, Bryan A., Cripps, Michael, Gunter, Oliver L., Holcomb, John B., Kerby, Jeffrey, Kornblith, Lucy Z., Moore, Ernest E., Riojas, Christina M., Schreiber, Martin, Sperry, Jason L., and Yeh, D. Dante

Published
2023
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72. Multi-level spectral deferred corrections scheme for the shallow water equations on the rotating sphere

Author

Hamon, François P, Schreiber, Martin, and Minion, Michael L

Subjects
Engineering, Mathematical Sciences, Physical Sciences, High-order time integration, Multi-level spectral deferred corrections, Implicit-explicit splitting, Atmospheric flows, Shallow-water equations on the rotating sphere, Spherical harmonics, Applied Mathematics, Mathematical sciences, Physical sciences
Abstract

Efficient time integration schemes are necessary to capture the complex processes involved in atmospheric flows over long periods of time. In this work, we propose a high-order, implicit–explicit numerical scheme that combines Multi-Level Spectral Deferred Corrections (MLSDC) and the Spherical Harmonics (SH) transform to solve the wave-propagation problems arising from the shallow-water equations on the rotating sphere. The iterative temporal integration is based on a sequence of corrections distributed on coupled space–time levels to perform a significant portion of the calculations on a coarse representation of the problem and hence to reduce the time-to-solution while preserving accuracy. In our scheme, referred to as MLSDC-SH, the spatial discretization plays a key role in the efficiency of MLSDC, since the SH basis allows for consistent transfer functions between space–time levels that preserve important physical properties of the solution. We study the performance of the MLSDC-SH scheme with shallow-water test cases commonly used in numerical atmospheric modeling. We use this suite of test cases, which gradually adds more complexity to the nonlinear system of governing partial differential equations, to perform a detailed analysis of the accuracy of MLSDC-SH upon refinement in time. We illustrate the stability properties of MLSDC-SH and show that the proposed scheme achieves up to eighth-order convergence in time. Finally, we study the conditions in which MLSDC-SH achieves its theoretical speedup, and we show that it can significantly reduce the computational cost compared to single-level Spectral Deferred Corrections (SDC).

Published
2019

73. Circulation first – the time has come to question the sequencing of care in the ABCs of trauma; an American Association for the Surgery of Trauma multicenter trial

Author

Ferrada, Paula, Callcut, Rachael A, Skarupa, David J, Duane, Therese M, Garcia, Alberto, Inaba, Kenji, Khor, Desmond, Anto, Vincent, Sperry, Jason, Turay, David, Nygaard, Rachel M, Schreiber, Martin A, Enniss, Toby, McNutt, Michelle, Phelan, Herb, Smith, Kira, Moore, Forrest O, Tabas, Irene, Dubose, Joseph, and AAST Multi-Institutional Trials Committee

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Physical Injury - Accidents and Adverse Effects, Clinical Trials and Supportive Activities, Good Health and Well Being, Adult, Blood Circulation, Female, Humans, Injury Severity Score, Male, Middle Aged, Multivariate Analysis, Resuscitation, Retrospective Studies, Shock, Hemorrhagic, Trauma Centers, Wounds and Injuries, Trauma resuscitation, Circulation first, Effects of intubation, Resuscitation in trauma, Trauma, Circulation, Hypovolemia and hypotension, Hypotension in trauma, Hypotension and resuscitation, AAST Multi-Institutional Trials Committee, Surgery, Clinical sciences
Abstract

BackgroundThe traditional sequence of trauma care: Airway, Breathing, Circulation (ABC) has been practiced for many years. It became the standard of care despite the lack of scientific evidence. We hypothesized that patients in hypovolemic shock would have comparable outcomes with initiation of bleeding treatment (transfusion) prior to intubation (CAB), compared to those patients treated with the traditional ABC sequence.MethodsThis study was sponsored by the American Association for the Surgery of Trauma multicenter trials committee. We performed a retrospective analysis of all patients that presented to trauma centers with presumptive hypovolemic shock indicated by pre-hospital or emergency department hypotension and need for intubation from January 1, 2014 to July 1, 2016. Data collected included demographics, timing of intubation, vital signs before and after intubation, timing of the blood transfusion initiation related to intubation, and outcomes.ResultsFrom 440 patients that met inclusion criteria, 245 (55.7%) received intravenous blood product resuscitation first (CAB), and 195 (44.3%) were intubated before any resuscitation was started (ABC). There was no difference in ISS, mechanism, or comorbidities. Those intubated prior to receiving transfusion had a lower GCS than those with transfusion initiation prior to intubation (ABC: 4, CAB:9, p = 0.005). Although mortality was high in both groups, there was no statistically significant difference (CAB 47% and ABC 50%). In multivariate analysis, initial SBP and initial GCS were the only independent predictors of death.ConclusionThe current study highlights that many trauma centers are already initiating circulation first prior to intubation when treating hypovolemic shock (CAB), even in patients with a low GCS. This practice was not associated with an increased mortality. Further prospective investigation is warranted.Trial registrationIRB approval number: HM20006627. Retrospective trial not registered.

Published
2018

74. Risk Factors for the Development of Acute Respiratory Distress Syndrome Following Hemorrhage

Author

Robinson, Bryce RH, Cohen, Mitchell J, Holcomb, John B, Pritts, Timothy A, Gomaa, Dina, Fox, Erin E, Branson, Richard D, Callcut, Rachael A, Cotton, Bryan A, Schreiber, Martin A, Brasel, Karen J, Pittet, Jean-Francois, Inaba, Kenji, Kerby, Jeffery D, Scalea, Thomas M, Wade, Charlie E, and Bulger, Eileen M

Subjects
Rare Diseases, Prevention, Clinical Research, Patient Safety, Acute Respiratory Distress Syndrome, Hematology, Physical Injury - Accidents and Adverse Effects, Clinical Trials and Supportive Activities, Lung, Respiratory, Good Health and Well Being, Adult, Blood Component Transfusion, Crystalloid Solutions, Disease-Free Survival, Female, Hemorrhage, Humans, Length of Stay, Male, Middle Aged, Respiratory Distress Syndrome, Survival Rate, Damage control resuscitation, lung injury, massive hemorrhage, resuscitation, trauma, PROPPR Study Group, Clinical Sciences, Emergency & Critical Care Medicine
Abstract

BackgroundThe Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) study evaluated the effects of plasma and platelets on hemostasis and mortality after hemorrhage. The pulmonary consequences of resuscitation strategies that mimic whole blood, remain unknown.MethodsA secondary analysis of the PROPPR study was performed. Injured patients predicted to receive a massive transfusion were randomized to 1:1:1 versus 1:1:2 plasma-platelet-red blood cell ratios at 12 Level I North American trauma centers. Patients with survival >24 h, an intensive care unit (ICU) stay, and a recorded PaO2/FiO2 (P/F) ratio were included. Acute respiratory distress syndrome (ARDS) was defined as a P/F ratio

Published
2018

75. Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial.

Author

Cardenas, Jessica C, Zhang, Xu, Fox, Erin E, Cotton, Bryan A, Hess, John R, Schreiber, Martin A, Wade, Charles E, Holcomb, John B, and PROPPR Study Group

Subjects
PROPPR Study Group, Humans, Wounds and Injuries, Disease-Free Survival, Platelet Transfusion, Survival Rate, Prospective Studies, Hemostasis, Time Factors, Adult, Middle Aged, Female, Male, Clinical Research, Clinical Trials and Supportive Activities, Hematology, Physical Injury - Accidents and Adverse Effects, Cardiovascular, Blood, Good Health and Well Being
Abstract

Transfusing platelets during massive hemorrhage is debated because of a lack of high-quality evidence concerning outcomes in trauma patients. The objective of this study was to examine the effect of platelet transfusions on mortality in severely injured trauma patients. This work analyzed PROPPR (Pragmatic, Randomized Optimal Platelet and Plasma Ratios) trial patients who received only the first cooler of blood products, which either did or did not contain platelets. Primary outcomes were all-cause mortality at 24 hours and 30 days and hemostasis. Secondary outcomes included cause of death, complications, and hospital-, intensive care unit (ICU)-, and ventilator-free days. Continuous variables were compared using Wilcoxon rank sum tests. Categorical variables were compared using Fisher's exact tests. There were 261 PROPPR patients who achieved hemostasis or died before receiving a second cooler of blood products (137 received platelets and 124 did not). Patients who received platelets also received more total plasma (median, 3 vs 2 U; P < .05) by PROPPR intervention design. There were no differences in total red blood cell transfusions between groups. After controlling for plasma volume, patients who received platelets had significantly decreased 24-hour (5.8% vs 16.9%; P < .05) and 30-day mortality (9.5% vs 20.2%; P < .05). More patients in the platelet group achieved hemostasis (94.9% vs 73.4%; P < .01), and fewer died as a result of exsanguination (1.5% vs 12.9%; P < .01). Patients who received platelets had a shorter time on mechanical ventilation (P < .05); however, no differences in hospital- or ICU-free days were observed. In conclusion, early platelet administration is associated with improved hemostasis and reduced mortality in severely injured, bleeding patients. This trial was registered at www.clinicaltrials.gov as # NCT01545232.

Published
2018

76. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma

Author

Potter, Daniel R, Miyazawa, Byron Y, Gibb, Stuart L, Deng, Xutao, Togaratti, Padma P, Croze, Roxanne H, Srivastava, Amit K, Trivedi, Alpa, Matthay, Michael, Holcomb, John B, Schreiber, Martin A, and Pati, Shibani

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Lung, Physical Injury - Accidents and Adverse Effects, Stem Cell Research - Nonembryonic - Human, Rare Diseases, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Aetiology, Cardiovascular, Animals, Capillary Permeability, Cells, Cultured, Disease Models, Animal, Endothelial Cells, Extracellular Vesicles, Flow Cytometry, Laparotomy, Lung Injury, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Mice, Mice, Inbred C57BL, Shock, Hemorrhagic, Hemorrhagic shock, vascular permeability, rhoA signaling, MSC EVs, mesenchymal stem cells, Clinical sciences, Nursing
Abstract

BACKGROUND:Mesenchymal stem cells (MSCs) have been shown to mitigate vascular permeability in hemorrhagic shock (HS) and trauma-induced brain and lung injury. Mechanistically, paracrine factors secreted from MSCs have been identified that can recapitulate many of the potent biologic effects of MSCs in animal models of disease. Interestingly, MSC-derived extracellular vesicles (EVs), contain many of these key soluble factors, and have therapeutic potential independent of the parent cells. In this study we sought to determine whether MSC-derived EVs (MSC EVs) could recapitulate the beneficial therapeutic effects of MSCs on lung vascular permeability induced by HS in mice. METHODS:Mesenchymal stem cell EVs were isolated from human bone marrow-derived MSCs by ultracentrifugation. A mouse model of fixed pressure HS was used to study the effects of shock, shock + MSCs and shock + MSC EVs on lung vascular endothelial permeability. Mice were administered MSCs, MSC EVs, or saline IV. Lung tissue was harvested and assayed for permeability, RhoA/Rac1 activation, and for differential phosphoprotein expression. In vitro, human lung microvascular cells junctional integrity was evaluated by immunocytochemistry and endothelial cell impedance assays. RESULTS:Hemorrhagic shock-induced lung vascular permeability was significantly decreased by both MSC and MSC EV infusion. Phosphoprotein profiling of lung tissue revealed differential activation of proteins and pathways related to cytoskeletal rearrangement and regulation of vascular permeability by MSCs and MSC EVs. Lung tissue from treatment groups demonstrated decreased activation of the cytoskeletal GTPase RhoA. In vitro, human lung microvascular cells, MSC CM but not MSC-EVs prevented thrombin-induced endothelial cell permeability as measured by electrical cell-substrate impedance sensing system and immunocytochemistry of VE-cadherin and actin. CONCLUSION:Mesenchymal stem cells and MSC EVs modulate cytoskeletal signaling and attenuate lung vascular permeability after HS. Mesenchymal stem cell EVs may potentially be used as a novel "stem cell free" therapeutic to treat HS-induced lung injury.

Published
2018

78. Detection of neutralizing antibodies against multiple SARS-CoV-2 strains in dried blood spots using cell-free PCR

Author

Danh, Kenneth, Karp, Donna Grace, Singhal, Malvika, Tankasala, Akshaya, Gebhart, David, de Jesus Cortez, Felipe, Tandel, Devangkumar, Robinson, Peter V., Seftel, David, Stone, Mars, Simmons, Graham, Bagri, Anil, Schreiber, Martin A., Buser, Andreas, Holbro, Andreas, Battegay, Manuel, Morris, Mary Kate, Hanson, Carl, Mills, John R., Granger, Dane, Theel, Elitza S., Stubbs, James R., Corash, Laurence M., and Tsai, Cheng-ting

Published
2022
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81. Adjunct Factor Replacement

Author

Gallaher, Jared R., Freeman, Christopher M., Schreiber, Martin A., Moore, Hunter B., editor, Neal, Matthew D., editor, and Moore, Ernest E., editor

Published
2021
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83. Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock

Author

Sperry, Jason L., primary, Luther, James F., additional, Okonkwo, David O., additional, Vincent, Laura E., additional, Agarwal, Vikas, additional, Cotton, Bryan A., additional, Cannon, Jeremy W., additional, Schreiber, Martin A., additional, Moore, Ernest E., additional, Namias, Nicholas, additional, Minei, Joseph P., additional, Urbanek, Kelly L., additional, Yazer, Mark H., additional, Puccio, Ava M., additional, Fox, Erin E., additional, Brown, Joshua B., additional, Neal, Matthew D., additional, Guyette, Frank X., additional, Wisniewski, Stephen R., additional, _, _, additional, Early-Young, Barbara J., additional, Buck, Meghan L., additional, Adams, Peter W., additional, Molinaro, Rachel L., additional, Merti, Alexandra, additional, Harner, Ashely M., additional, Gimbel, Elizabeth A., additional, Owens, Logan, additional, Hayes, Hannah, additional, Jackson, Alan, additional, Silfies, Laurie, additional, Over, Lisa, additional, Knopf, Steve, additional, Macey-Kalcevic, Melody, additional, Pattison, Angela, additional, Buhay, Megan E., additional, Higginbottom, Brianna J., additional, Marcin, Marissa L., additional, Battistella, Cara, additional, Bai, Yu, additional, Motley, Kandice L., additional, Wang, Yao-Wei, additional, Herrick, Victoria, additional, Woodruff, Garrett, additional, Pa, Veda, additional, Hobbs, Rhonda, additional, Podbielski, Jeanette, additional, Vincent, Laura, additional, Allen, Christy, additional, Alexander, Subin, additional, Hamilton, Natolie, additional, Lopez, Symantha, additional, Gonzalez, Selina Hernandez, additional, Rashall, Jason, additional, Seymour, James, additional, Zarate, Nicole, additional, Zone, Alea, additional, Joergensen, Sarah, additional, Forsythe, Liam, additional, Zaitseva, Daria, additional, Callahan, Paul, additional, Khan, Komal, additional, Doran, Olivia, additional, Gamblin, Sarah, additional, Fisher, Lydia, additional, Schmulevich, Daniela, additional, Balian, Steve, additional, Diamond, Carrie, additional, Kolansky, Jonathan, additional, Torrente, Dena, additional, Van Walchren, Sean, additional, Lape, Diane, additional, Sauaia, Angela, additional, Haukoos, Jason, additional, Ammons, Lee Anne, additional, Chandler, James, additional, Fitzpatrick, Marcela, additional, Vittatoe, Emmalee, additional, Brant, Nick, additional, Kennedy, Stephanie, additional, Swope, Megan, additional, Manning, Ronald, additional, Fonnegra, Cristina Botero, additional, Brito, Sebastian, additional, Calderon, Vivian, additional, Chammas, Majid, additional, Dure, Anthony, additional, Ferreira, Chelsea, additional, Ferreira, Allison, additional, Guerra, Richard, additional, Guzman, Ivonne, additional, Jolly, Aaliyah, additional, Ramdev, Rajan, additional, Reddy, Shreedhar, additional, and Nassaj, Nadia, additional

Published
2024
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86. Plasma Resuscitation Improved Survival in a Cecal Ligation and Puncture Rat Model of Sepsis

Author

Chang, Ronald, Holcomb, John B, Johansson, Pär I, Pati, Shibani, Schreiber, Martin A, and Wade, Charles E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Infectious Diseases, Hematology, Physical Injury - Accidents and Adverse Effects, Animals, Cecum, Disease Models, Animal, Male, Plasma, Punctures, Rats, Rats, Sprague-Dawley, Resuscitation, Sepsis, Endothelium, fluid therapy, septic shock, Emergency & Critical Care Medicine, Clinical sciences
Abstract

BackgroundThe paradigm shift from crystalloid to plasma resuscitation of traumatic hemorrhagic shock has improved patient outcomes due in part to plasma-mediated reversal of catecholamine and inflammation-induced endothelial injury, decreasing vascular permeability and attenuating organ injury. Since sepsis induces a similar endothelial injury as seen in hemorrhage, we hypothesized that plasma resuscitation would increase 48-h survival in a rat sepsis model.MethodsAdult male Sprague-Dawley rats (375-425 g) were subjected to 35% cecal ligation and puncture (CLP) (t = 0 h). Twenty-two hours post-CLP and prior to resuscitation (t = 22 h), animals were randomized to resuscitation with normal saline (NS, 10 cc/kg/h) or pooled rat fresh frozen plasma (FFP, 3.33 cc/kg/h). Resuscitation under general anesthesia proceeded for the next 6 h (t = 22 h to t = 28 h); lactate was checked every 2 h, and fluid volumes were titrated based on lactate clearance. Blood samples were obtained before (t = 22 h) and after resuscitation (t = 28 h), and at death or study conclusion. Lung specimens were obtained for calculation of wet-to-dry weight ratio. Fisher exact test was used to analyze the primary outcome of 48-h survival. ANOVA with repeated measures was used to analyze the effect of FFP versus NS resuscitation on blood gas, electrolytes, blood urea nitrogen (BUN), creatinine, interleukin (IL)-6, IL-10, catecholamines, and syndecan-1 (marker for endothelial injury). A two-tailed alpha level of

Published
2018

89. Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism

Author

McCully, Belinda H, Connelly, Christopher R, Fair, Kelly A, Holcomb, John B, Fox, Erin E, Wade, Charles E, Bulger, Eileen M, Schreiber, Martin A, Group, PROPPR Study, del Junco, Deborah J, Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M, Tilley, Barbara C, Baraniuk, Sarah, Nixon, Joshua, Seay, Roann, Appana, Savitri N, Yang, Hui, Gonzalez, Michael O, Baer, Lisa, Wang, Yao-Wei Willa, Hula, Brittany S, Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D, Sharma, Rishika, Cardenas, Jessica C, Rahbar, Elaheh, Burnett, Tyrone, Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P, Hess, John R, Callum, Jeanne, Cotton, Bryan A, Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G, Gumbert, Sam D, Bai, Yu, McCarthy, James J, Noland, Amy, Hobbs, Rhonda, Klotz, Patricia, Cattin, Lindsay, Warner, Keir J, Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A, Cohen, Mitchell Jay, Callcut, Rachael A, Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P, Maxim, Preston C, Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A, Robinson, Bryce RH, Branson, Richard D, Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M, Miller, Christopher N, Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G, Wong, Monica D, Menchine, Michael, Katzberg, Kelly, Henderson, Sean O, McKeever, Rodney, Shulman, Ira A, Nelson, Janice M, Tuma, Christopher W, Matsushita, Cheryl Y, Scalea, Thomas M, Stein, Deborah M, Shaffer, Cynthia K, and Wade, Christine

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Physical Injury - Accidents and Adverse Effects, Hematology, Clinical Research, Cardiovascular, Adult, Anticoagulants, Blood Coagulation Disorders, Blood Coagulation Tests, Female, Humans, Injury Severity Score, Male, Middle Aged, Recovery of Function, Thrombelastography, Trauma Centers, Venous Thromboembolism, Wounds and Injuries, PROPPR Study Group, Surgery, Clinical sciences
Abstract

BackgroundAltered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients.Study designSecondary analysis was performed on data from the Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours or were on pre-injury anticoagulants. Patient characteristics, adverse outcomes, and parameters of platelet function and coagulation (thromboelastography) were compared from admission to 72 hours between VTE (n = 83) and non-VTE (n = 475) patients. A p value < 0.05 indicates significance.ResultsDespite similar patient demographics, VTE patients exhibited hypercoagulable thromboelastography parameters and enhanced platelet function at admission (p < 0.05). Both groups exhibited hypocoagulable thromboelastography parameters, platelet dysfunction, and suppressed clot lysis (low clot lysis at 30 minutes) 2 hours after admission (p < 0.05). The VTE patients exhibited delayed coagulation recovery (a significant change compared with 2 hours) of K-value (48 vs 24 hours), α-angle (no recovery), maximum amplitude (24 vs 12 hours), and clot lysis at 30 minutes (48 vs 12 hours). Platelet function recovery mediated by arachidonic acid (72 vs 4 hours), ADP (72 vs 12 hours), and collagen (48 vs 12 hours) was delayed in VTE patients. The VTE patients had lower mortality (4% vs 13%; p < 0.05), but fewer hospital-free days (0 days [interquartile range 0 to 8 days] vs 10 days [interquartile range 0 to 20 days]; p < 0.05) and higher complication rates (p < 0.05).ConclusionsRecovery from platelet dysfunction and coagulopathy after severe trauma were delayed in VTE patients. Suppressed clot lysis and compensatory mechanisms associated with altered coagulation that can potentiate VTE formation require additional investigation.

Published
2017

90. Outcomes Following Concomitant Traumatic Brain Injury and Hemorrhagic Shock: A Secondary Analysis from the PROPPR Trial.

Author

Galvagno, Samuel M, Fox, Erin E, Appana, Savitri N, Baraniuk, Sarah, Bosarge, Patrick L, Bulger, Eileen M, Callcut, Rachel A, Cotton, Bryan A, Goodman, Michael, Inaba, Kenji, O'Keeffe, Terence, Schreiber, Martin A, Wade, Charles E, Scalea, Thomas M, Holcomb, John B, and Stein, Deborah M

Subjects
Traumatic Head and Spine Injury, Neurosciences, Traumatic Brain Injury (TBI), Brain Disorders, Lung, Physical Injury - Accidents and Adverse Effects, Injuries and accidents, Good Health and Well Being, Abbreviated Injury Scale, Adult, Blood Coagulation Disorders, Blood Transfusion, Brain Injuries, Traumatic, Critical Care, Female, Humans, Incidence, Logistic Models, Male, Middle Aged, Shock, Hemorrhagic, Treatment Outcome, Injury - Traumatic brain injury, Injury - Trauma - (Head and Spine), Injury (total) Accidents/Adverse Effects, Traumatic brain injury, hemorrhagic shock, resuscitation, trauma, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Nursing, Emergency & Critical Care Medicine
Abstract

Often the clinician is faced with a diagnostic and therapeutic dilemma in patients with concomitant traumatic brain injury (TBI) and hemorrhagic shock (HS), as rapid deterioration from either can be fatal. Knowledge about outcomes following concomitant TBI and HS may help prioritize the emergent management of these patients. We hypothesized that patients with concomitant TBI and HS (TBI+HS) had worse outcomes and required more intensive care compared to patients with only one of these injuries.This is a post-hoc analysis of the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial. TBI was defined by a head abbreviated injury scale >2. HS was defined as a base excess ≤ -4 and/or shock index ≥ 0.9. The primary outcome for this analysis was mortality at 30 days. Logistic regression, using generalized estimating equations (GEE), was used to model categorical outcomes.670 patients were included. Patients with TBI+HS had significantly higher lactate (median 6.3; IQR 4.7,9.2) compared to the TBI group (median 3.3; IQR 2.3,4). TBI+HS patients had higher activated prothrombin times and lower platelet counts. Unadjusted mortality was higher in the TBI+HS (51.6%) and TBI (50%) groups compared to the HS (17.5%) and neither group (7.7%). Adjusted odds of death in the TBI and TBI+HS groups were 8.2 (95% CI, 3.4-19.5) and 10.6 (95% CI, 4.8-23.2) times higher, respectively. Ventilator, ICU- and hospital-free days were lower in the TBI and TBI+HS groups compared to the other groups. Patients with TBI+HS or TBI had significantly greater odds of developing a respiratory complication compared to the neither group.The addition of TBI to HS is associated with worse coagulopathy prior to resuscitation, and increased mortality. When conrolling for multiple known confounders, the diagnosis of TBI alone or TBI+HS was associated with significantly greater odds of developing respiratory complications.prognostic study LEVEL OF EVIDENCE: II.

Published
2017

94. A Decentralized Parallelization-in-Time Approach with Parareal

Author

Schreiber, Martin, Peddle, Adam, Haut, Terry, and Wingate, Beth

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Performance
Abstract

With steadily increasing parallelism for high-performance architectures, simulations requiring a good strong scalability are prone to be limited in scalability with standard spatial-decomposition strategies at a certain amount of parallel processors. This can be a show-stopper if the simulation results have to be computed with wallclock time restrictions (e.g.\,for weather forecasts) or as fast as possible (e.g. for urgent computing). Here, the time-dimension is the only one left for parallelization and we focus on Parareal as one particular parallelization-in-time method. We discuss a software approach for making Parareal parallelization transparent for application developers, hence allowing fast prototyping for Parareal. Further, we introduce a decentralized Parareal which results in autonomous simulation instances which only require communicating with the previous and next simulation instances, hence with strong locality for communication. This concept is evaluated by a prototypical solver for the rotational shallow-water equations which we use as a representative black-box solver.

Published
2015

96. Cache-Aware Matrix Polynomials

Author

Huber, Dominik, Schreiber, Martin, Yang, Dai, Schulz, Martin, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Krzhizhanovskaya, Valeria V., editor, Závodszky, Gábor, editor, Lees, Michael H., editor, Dongarra, Jack J., editor, Sloot, Peter M. A., editor, Brissos, Sérgio, editor, and Teixeira, João, editor

Published
2020
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