Author: "Schaffar G" - Searchworks@Jio Institute Digital Library Search Results

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51. Anforderungen an Zeitgemäsze VLSI-IC-Testsysteme

Author: Jäger, F., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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52. Zuverlässigkeit von Elektrolytkondensatoren

Author: Walther, G., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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53. Einsatz Bipolarer Transistoren in CMOS-Operationsverstärkern

Author: Gauby, A., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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54. Die Erweiterung von MINIMOS auf ein 3D Simulationsprogramm

Author: Thurner, M., Selberherr, S., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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55. Standards zur Software-Qualitätssicherung und Sicherheit

Author: Schoitsch, Erwin, Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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56. Massnahmen zur Sicherung der Zuverlässigkeit im Prozessdatensystem mPDS 4000

Author: Leopold, H., Röhrer, R., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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57. Ein Spannungsregler mit Unterlagerter, Getakteter Stromregelung

Author: Leopold, H., Winkler, G., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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58. Zwei-Dimensionale Transiente Simulation des Einschaltverhaltens eines Planaren MOS-Transistors

Author: Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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59. Steckverbinder für SMT — 'Exoten' in der Oberflächenmontage?

Author: Holzmann, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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60. Betrachtungen zur Sicherheit und Zuverlässigkeit von Individualwarnanlagen

Author: List, G., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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61. ASIC-Design for Testability

Author: Holzmann, D., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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62. Die Verwendung der 'ODER'-Verknüpfung im Fehlerbaum zur Berechnung der Sicherheit

Author: Dejneka, B., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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63. Entwicklung und Anwendung Eines Elektronischen Dieselmotormanagementsystems

Author: Bittinger, W., Kainz, A., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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64. Darstellung von Testergebnissen an VLSI — Schaltungen

Author: Hoffmann, G., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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65. Ein Hierarchisches Steuerungssystem in der Fördertechnik

Author: Jorde, Ch., Hirschler, M., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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66. Ambulante Herzüberwachung

Author: Wieβpeiner, G., Grübler, R., Schuy, S., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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67. Implantierbarer Atemschrittmacher — Funktionelle Elektrische Stimulation des Zwerchfells

Author: Mayr, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Stöhr, H., Thoma, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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68. Testgerät für Iridium Strahler

Author: Prager, L., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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69. Kreative Künstliche Intelligenz — Systeme und Ihre Sozialen und Gesellschaftlichen Einflüsse

Author: Scholz-Nauendorff, C. C., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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70. B D E-240 Terminal für Systeme zur Erfassung von Betriebsdaten

Author: Volkmann, W., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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71. Feldberechnung in einem Elektrooptischen Modulator mit der Methode der Finiten Elemente

Author: Renner, A., Bratengeyer, E., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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72. Automatische Wetterdatenerfassung im Sonnblick-Observatorium

Author: Rosenkranz, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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73. Intelligente Automatisation unter Nutzung der Neuesten Microcomputersysteme, Kommunikationskonzepte

Author: Gutternigh, K., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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74. Intelligenter Datenspeicher mit V24 Schnittstelle

Author: Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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75. AVG 85

Author: Klösch, W., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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76. Tragbares Strahlenschutzmessgerät SSM1

Author: Klösch, W., Böck, N., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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77. Anwendungen der Mikroelektronik in der Österreichischen Industrie — Darstellung des Anwendungsstandes und der Effekte in Produktion und Produkten

Author: Tritremmel, W., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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78. Zuverlässigkeit von Keramischen Bauelementen, Insbesondere für Oberflächenmontage

Author: Seiner, K., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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79. Sensoren für die Klimatechnik

Author: Mitter, H., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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80. Ein-Chip-Modem nach dem CCITT V.22 Standard

Author: Lebutsch, K., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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81. Vorteile der Programmiersprache Forth für die Steuerung einer Betonmischanlage

Author: Hengl, M., Nussbaum, G., Hoffmann, G., Holzmann, D., Jäger, F., Riedling, K., Schwuttke, G. H., Pandelisev, K. A., White, R. C., Holzmann, H., Kausel, W., Nanz, G., Selberherr, S., Pötzl, H., Leopold, H., Röhrer, R., Winkler, G., Thurner, M., Seiner, K., Tritremmel, W., Walther, G., Schoitsch, Erwin, Hertl, S., Schaffar, G., Schmidt, K., Steinbrecher, H., Voggenberger, F., Windischhofer, W., Turba, R., Grabner, J., Aberl, H., Seifert, F., Buschbeck, F., Wallisch, K., Eichtinger, Ch., Wach, P., Bittinger, W., Kainz, A., Jestl, M., Beinstingl, W., Berthold, K., Köck, A., Gornik, E., Kloiber, G., Kreid, F., Schröcker, K. P., Schrödl, M., Brazda, E., Niedrist, G., Dietz, K., Fey, P., Frenkenberger, S., Furtner, M., Dejneka, B., Goiser, A., Sust, M., Kowatsch, M., Jorde, Ch., Thallinger, G. G., Mothwurf, E., Schubert, E., Steger, J., Trzeba, E., Awramow, I., Pucher, R., Auer, L. M., Schuy, S., Schima, H., Huber, L., Prodinger, A., Schmallegger, H., Thoma, H., Stöhr, H., Mayr, W., Steiner, R., Wiedenbauer, O., List, G., Wießpeiner, G., Petsch, Th., Doblhoff, G., Kirchner, D., Koudelka, O., Gierlinger, A., Ullrich, A., Braune, B., Horvat, H., Mayer, U., Gauby, A., Richter, A., Spiess, K. R., Klösch, W., Böck, N., Rosenkranz, H., Mitter, H., Hengl, M., Nussbaum, G., Gutternigh, K., Hahn, H., Koutny, P., Pühringer, K., Schwabach, H., Hirschler, M., Haas, M., Renner, A., Bratengeyer, E., Scholz-Nauendorff, C. C., Lebutsch, K., Volkmann, W., Gerner, H., Girsch, W., Holle, J., Kluger, P., Meister, B., Moritz, E., Schwanda, G., Prager, L., Wieβpeiner, G., Grübler, R., Dorfer, E., Oitzl, E., Pribyl, W., Bähring, M., Harter, J., and Sommer, D.
Published: 1987
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82. A review of the totality of evidence supporting the development and approval of a pegfilgrastim biosimilar (LA-EP2006).

Author: Agarwala SS, Nagl U, Guo X, Bellon A, Heyn J, Dimova-Dobreva M, Shen YM, Schaffar G, Humphrey M, Mathieson N, Koptelova N, and Gattu S
Subjects: Adult, Filgrastim therapeutic use, Humans, Polyethylene Glycols therapeutic use, Therapeutic Equivalency, United States, Biosimilar Pharmaceuticals adverse effects
Abstract: Objective: The totality-of-evidence approach requires that similarity between a proposed biosimilar and a reference biologic is demonstrated across a range of analytical, preclinical, and clinical parameters to establish biosimilarity. We describe the totality of evidence for Sandoz biosimilar pegfilgrastim (LA-EP2006 [marketed as Ziextenzo]) that supported its regulatory approval in Europe and the United States., Methods: Analytical similarity to the reference biologic [marketed by Amgen as Neulasta] was first investigated with regard to physiochemical quality attributes such as primary structure, pegylation, higher-order structures, variants and impurities, molecular size variants, and formulation (protein content, pH, excipients, etc.). In vitro biological activity studies were performed to examine the primary mechanism of action of pegfilgrastim. Bioequivalence (clinical pharmacokinetics [PK] and pharmacodynamics [PD]) of Sandoz biosimilar pegfilgrastim to the reference biologic was studied in healthy volunteers; efficacy, safety, and immunogenicity were assessed during confirmatory clinical efficacy studies in patients undergoing treatment for breast cancer., Results: No meaningful or relevant differences were identified between Sandoz biosimilar pegfilgrastim and the reference biologic during analytical testing. Similar receptor binding and induction of cellular proliferation in vitro confirmed no functional differences between the biologics. Clinical studies in healthy adult participants demonstrated PK/PD biosimilarity and a similar safety profile between biosimilar and reference pegfilgrastim. Clinical studies in a sensitive patient population also demonstrated similar efficacy, safety, and immunogenicity between Sandoz biosimilar pegfilgrastim and the reference biologic., Conclusions: The totality of evidence confirms that Sandoz biosimilar pegfilgrastim matches the reference biologic and will therefore provide equivalent efficacy and safety in all eligible indications.
Published: 2022
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83. Recommendations for the Development and Validation of Immunogenicity Assays in Support of Biosimilar Programs.

Author: Civoli F, Kasinath A, Cai XY, Wadhwa M, Exley A, Oldfield P, Alvandkouhi S, Schaffar G, Chappell J, Bowsher R, Devanarayan V, Marini J, Rebarchak S, Anderson M, Koppenburg V, and Lester T
Subjects: Validation Studies as Topic, Biosimilar Pharmaceuticals, Immunologic Techniques
Abstract: For biosimilar drug development programs, it is essential to demonstrate that there are no clinically significant differences between the proposed biosimilar therapeutic (biosimilar) and its reference product (originator). Based on a stepwise comprehensive comparability exercise, the biosimilar must demonstrate similarity to the originator in physicochemical characteristics, biological activity, pharmacokinetics, efficacy, and safety, including immunogenicity. The goal of the immunogenicity assessment is to evaluate potential differences between the proposed biosimilar product and the originator product in the incidence and severity of human immune responses. Establishing that there are no clinically meaningful differences in the immune response between the products is a key element in the demonstration of biosimilarity. An issue of practical, regulatory, and financial importance is to establish whether a two-assay (based on the biosimilar and originator respectively) or a one-assay approach (based on the biosimilar) is optimal for the comparative immunogenicity assessment. This paper recommends the use of a single, biosimilar-based assay for assessing immunogenic similarity in support of biosimilar drug development. The development and validation of an ADA assay used for a biosimilar program should include all the assessments recommended for an innovator program (10-16, 29). In addition, specific parameters also need to be evaluated, to gain confidence that the assay can detect antibodies against both the biosimilar and the originator. Specifically, the biosimilar and the originator should be compared in antigenic equivalence, to assess the ability of the biosimilar and the originator to bind in a similar manner to the positive control(s), as well as in the confirmatory assay and drug tolerance experiments. Practical guidance for the development and validation of anti-drug antibody (ADA) assays to assess immunogenicity of a biosimilar in comparison to the originator, using the one-assay approach, are described herein.
Published: 2019
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84. Proposed biosimilar pegfilgrastim shows similarity in pharmacokinetics and pharmacodynamics to reference pegfilgrastim in healthy subjects.

Author: Nakov R, Gattu S, Wang J, Velinova M, Schaffar G, and Skerjanec A
Subjects: Adult, Cross-Over Studies, Double-Blind Method, Female, Filgrastim adverse effects, Filgrastim immunology, Filgrastim pharmacology, Healthy Volunteers, Humans, Male, Polyethylene Glycols adverse effects, Polyethylene Glycols pharmacology, Biosimilar Pharmaceuticals pharmacokinetics, Filgrastim pharmacokinetics, Polyethylene Glycols pharmacokinetics
Abstract: Aims: This study aimed to demonstrate that the pharmacokinetic (PK) and pharmacodynamic (PD) profile of Sandoz proposed biosimilar pegfilgrastim (LA-EP2006) matches reference pegfilgrastim (Neulasta ® ) in healthy subjects. Safety and immunogenicity were also assessed., Methods: The phase I, randomized, double-blind, two-period crossover study consisted of two treatment periods separated by an 8-week washout period. Healthy subjects aged 18-45 were randomized to either proposed biosimilar/reference pegfilgrastim or reference pegfilgrastim/proposed biosimilar. Proposed biosimilar and reference pegfilgrastim were administered on Day 1 of each treatment period (single 6 mg subcutaneous injection). Blood samples for PK/PD analysis were taken predose and ≤336 h postdose. PK/PD similarity was claimed if 90% (PK) and 95% (PD) confidence intervals (CI) for geometric mean ratios of the area under the serum concentration-time curve (AUC) from time of dosing and extrapolated to infinity (AUC 0-inf ), or to the last measurable concentration (AUC 0-last ), maximum observed serum concentration (C max ), absolute neutrophil count (ANC) area under the effect curve from the time of dosing to the last measurable concentration (AUEC 0-last ) and ANC maximum effect attributable to the therapy under investigation (E max ) were completely contained within the predefined margin (0.8 to 1.25)., Results: Overall, 169 subjects completed the study. PK/PD similarity was demonstrated; 90% CIs of geometric mean ratio of proposed biosimilar/reference for PK: AUC 0-inf (1.0559-1.2244), AUC 0-last (1.0607-1.2328), C max (1.0312-1.1909) and 95% CIs for PD (ANC): AUEC 0-last (0.9948-1.0366), E max (0.9737-1.0169) were completely contained within predefined margin of 0.8 to 1.25. Both biologics had similar safety profiles, were well tolerated and had low incidence of anti-drug antibodies. No neutralizing or clinically relevant antibodies were detected., Conclusions: PK/PD similarity of Sandoz proposed biosimilar pegfilgrastim and reference pegfilgrastim was confirmed. No clinically meaningful differences in safety, tolerability and immunogenicity were observed in healthy subjects., (© 2018 The British Pharmacological Society.)
Published: 2018
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85. Evaluation of the safety and immunogenicity of subcutaneous HX575 epoetin alfa in the treatment of anemia associated with chronic kidney disease in predialysis and dialysis patients .

Author: Casadevall N, Dobronravov V, Eckardt KU, Ertürk S, Martynyuk L, Schmitt S, Schaffar G, Rudy A, Krendyukov A, and Ode M
Subjects: Adult, Aged, Anemia etiology, Epoetin Alfa therapeutic use, Erythropoietin, Europe, Female, Hematinics therapeutic use, Humans, Male, Middle Aged, Recombinant Proteins therapeutic use, Renal Insufficiency, Chronic therapy, Anemia drug therapy, Epoetin Alfa adverse effects, Hematinics adverse effects, Recombinant Proteins adverse effects, Renal Dialysis adverse effects, Renal Insufficiency, Chronic complications
Abstract: Aim: To assess the safety and immunogenicity of subcutaneous (SC) HX575 (epoetin-α) in dialysis- and nondialysis-dependent adult patients with chronic kidney disease (CKD)., Methods: Open-label, single-arm, multicenter study in patients (n = 416) from Germany, Italy, Poland, Romania, Russia, Turkey, and Ukraine., Results: Mean (standard deviation (SD)) age was 52.3 (15.8) years, all patients were Caucasian, and similar proportions were male/female. 250 patients (60.1%) were erythropoiesis-stimulating agent (ESA)-naïve, and 166 (39.9%) were receiving ESA maintenance therapy at study start; mean (SD) on-study treatment duration with HX575 was 43.4 (15.8) weeks and 45.3 (13.7) weeks, respectively. Binding antierythropoietin (EPO) antibodies were detected by radioimmunoprecipitation (RIP) assay in 7 patients (1.7%; incidence 0.019); 5 of these were ESA-naïve at study entry. No patient developed neutralizing antibodies as determined in a cell-based epoetin neutralizing assay. Of the 7 patients with a positive binding anti-EPO RIP assay, 4 tested negative at later time points while continuing HX575 treatment. Three patients had low titers of anti-EPO antibodies at the last study assessment. There were no clinical signs of immunogenicity or hypersensitivity., Conclusions: SC HX575 was effective for correcting and maintaining correction of anemia, and the mean weekly dose remained stable over time. .
Published: 2017
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86. A Comparison of the Safety and Efficacy of HX575 (Epoetin Alfa Proposed Biosimilar) with Epoetin Alfa in Patients with End-Stage Renal Disease.

Author: Weir MR, Pergola PE, Agarwal R, Fink JC, Kopyt NP, Singh AK, Kumar J, Schmitt S, Schaffar G, Rudy A, McKay JP, and Kanceva R
Subjects: Adult, Aged, Aged, 80 and over, Anemia blood, Double-Blind Method, Female, Hemoglobins analysis, Humans, Kidney Failure, Chronic blood, Male, Middle Aged, Renal Dialysis, Therapeutic Equivalency, Treatment Outcome, United States, Young Adult, Anemia drug therapy, Biosimilar Pharmaceuticals therapeutic use, Epoetin Alfa therapeutic use, Hematinics therapeutic use, Kidney Failure, Chronic drug therapy
Abstract: Background: HX575 (biosimilar epoetin alfa) was approved in Europe in 2007 for the treatment of chronic kidney disease (CKD)-related anemia. This study assessed the clinical equivalence of HX575 with the US-licensed reference epoetin alfa (Epogen®/Procrit®, Amgen/Janssen) following subcutaneous (SC) administration in dialysis patients with CKD-related anemia., Methods: This randomized, double-blind, parallel-group, multicenter study (NCT01693029) was conducted at 49 US clinical sites. Eligible patients were aged ≥18 years, had end-stage renal disease, were on hemodialysis or peritoneal dialysis for ≥6 months (or ≥12 months in the case of a failed kidney transplant), and were receiving treatment with stable SC doses of epoetin alfa. Eligible patients also had mean hemoglobin (Hb) concentration between 9.0 and 11.5 g/dL during the screening period. The primary endpoint was the mean absolute change in Hb concentration between the screening/baseline period (week-4 to week-1) and the evaluation period (weeks 21 to 28)., Results: Hb values at the end of the evaluation period and the Hb change from baseline to evaluation period were similar between treatment groups. The estimated difference between groups in mean absolute change in Hb concentration was -0.093 g/dL, with 90% CI (-0.23 to 0.04) entirely within the pre-specified equivalence limits (-0.5 to 0.5 g/dL). The safety profile of each medicine was similar and as expected in dialysis patients, and neither method of treatment led to the development of neutralizing, clinically relevant antibodies., Conclusions: SC HX575 in dialysis patients with renal anemia was therapeutically equivalent to the reference medicine in terms of maintaining stable Hb levels and safety., (© 2017 S. Karger AG, Basel.)
Published: 2017
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87. A Comparison of Proposed Biosimilar LA-EP2006 and Reference Pegfilgrastim for the Prevention of Neutropenia in Patients With Early-Stage Breast Cancer Receiving Myelosuppressive Adjuvant or Neoadjuvant Chemotherapy: Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2), a Phase III, Randomized, Double-Blind Trial.

Author: Blackwell K, Donskih R, Jones CM, Nixon A, Vidal MJ, Nakov R, Singh P, Schaffar G, Gascón P, and Harbeck N
Subjects: Adult, Bone Marrow drug effects, Breast Neoplasms pathology, Double-Blind Method, Female, Filgrastim, Granulocyte Colony-Stimulating Factor adverse effects, Humans, Middle Aged, Neoplasm Staging, Polyethylene Glycols, Prospective Studies, Recombinant Proteins adverse effects, Recombinant Proteins therapeutic use, Biosimilar Pharmaceuticals therapeutic use, Breast Neoplasms drug therapy, Granulocyte Colony-Stimulating Factor therapeutic use, Neoadjuvant Therapy, Neutropenia prevention & control
Abstract: Background: Pegfilgrastim is widely used for the prevention of chemotherapy-induced neutropenia. In highly regulated markets, there are currently no approved biosimilars of pegfilgrastim. Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2) was a confirmatory efficacy and safety study designed to compare proposed biosimilar LA-EP2006 with reference pegfilgrastim (Neulasta, Amgen) in early-stage breast cancer patients receiving adjuvant or neoadjuvant myelosuppressive chemotherapy., Methods: A total of 308 patients were randomized to LA-EP2006 or reference pegfilgrastim. Each patient received TAC (intravenous docetaxel 75 mg/m(2), doxorubicin 50 mg/m(2), and cyclophosphamide 500 mg/m(2)) on day 1 of each cycle, for six or more cycles. Pegfilgrastim (LA-EP2006 or reference) was given subcutaneously (6 mg in 0.6 mL) on day 2 of each cycle. The primary endpoint was duration of severe neutropenia (DSN) during cycle 1 (number of consecutive days with an absolute neutrophil count <0.5 × 10(9)/L), with equivalence confirmed if 90% and 95% confidence intervals (CIs) were within a 1-day margin., Results: Baseline characteristics were well balanced. DSN was equivalent between groups at mean ± SD 1.36 ± 1.13 (LA-EP2006, n = 155) and 1.19 ± 0.98 (reference, n = 153) in cycle 1. With a treatment difference (reference minus LA-EP2006) of -0.16 days (90% CI -0.36 to 0.04; 95% CI -0.40 to 0.08), LA-EP2006 was equivalent to reference pegfilgrastim. Secondary efficacy parameters were similar between groups during cycle 1 and across cycles. Safety profiles were also similar between groups. No neutralizing antibodies against pegfilgrastim, filgrastim, or polyethylene glycol were detected., Conclusion: LA-EP2006 and reference pegfilgrastim were therapeutically equivalent and comparable regarding efficacy and safety in the prevention of neutropenia in patients with early-stage breast cancer receiving TAC., Implications for Practice: The granulocyte colony-stimulating factor pegfilgrastim is widely used for the prevention of chemotherapy-induced neutropenia. Biosimilars are biologics with similar quality, safety, and efficacy to a reference product that may increase the affordability of treatment compared with their reference compounds. There are currently no approved biosimilars of pegfilgrastim in highly regulated markets. No previous phase III studies have been performed with LA-EP2006. PROTECT-2 was conducted to confirm the similarity of the proposed biosimilar LA-EP2006 to pegfilgrastim. Biosimilar pegfilgrastim (LA-EP2006) may benefit oncology patients by offering increased access to biological treatments that may improve clinical outcomes. This means that patients could potentially be treated prophylactically with biologics rather than only after complications have occurred., (©AlphaMed Press.)
Published: 2016
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88. LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin.

Author: Schaffar G, Taniguchi J, Brodbeck T, Meyer AH, Schmidt M, Yamashita T, and Mueller BK
Subjects: Adaptor Proteins, Signal Transducing, Amides pharmacology, Analysis of Variance, Animals, Cells, Cultured, Cerebral Cortex cytology, Embryo, Mammalian, Enzyme Inhibitors pharmacology, GPI-Linked Proteins, Gene Expression drug effects, Green Fluorescent Proteins biosynthesis, Homeodomain Proteins biosynthesis, Humans, LIM Domain Proteins, Neurites drug effects, Neurites physiology, Neurons cytology, Neurons drug effects, Protein Structure, Tertiary, Pyridines pharmacology, RNA, Small Interfering pharmacology, Rats, Transcription Factors biosynthesis, Transfection methods, Tubulin pharmacology, Two-Hybrid System Techniques, rhoA GTP-Binding Protein genetics, rhoA GTP-Binding Protein metabolism, Homeodomain Proteins metabolism, Membrane Glycoproteins metabolism, Membrane Proteins metabolism, Nerve Tissue Proteins metabolism, Neurons physiology, Transcription Factors metabolism
Abstract: Repulsive guidance molecule A (RGM A) was recently described as a potent inhibitor of neuroregeneration in a rat spinal cord injury model. The receptor mediating RGM A's repulsive activity was shown to be Neogenin, a member of the Deleted in Colorectal Cancer (DCC) family of netrin receptors. Binding of RGM A to Neogenin induces activation of the small GTPase RhoA and of its effector Rho-kinase by an unknown mechanism. Here we show, that the cytoplasmic tail of Neogenin interacts directly with the transcriptional coactivator LIM domain only 4 (LMO4) in human SH-SY5Y cells, human Ntera neurons, and in embryonic rat cortical neurons. RGM A binding to Neogenin but not binding of Netrin-1, induces release of LMO4 from Neogenin. Down-regulation of LMO4 neutralizes the repulsive activity of RGM A in neuronal cell lines and embryonic rat cortical neurons and prevents RhoA activation. These results show for the first time that an interaction of Neogenin with LMO4 is involved in the RGM A - Neogenin signal transduction pathway for RhoA activation.
Published: 2008
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89. Now we are talking sense! Functional approaches to novel nutraceuticals and cosmeceuticals.

Author: Krohn M, Kleber A, Schaffar G, Dechert U, and Eck J
Subjects: Cosmetics chemistry, Drug Industry methods, Drug Industry trends, Humans, Models, Biological, Pharmaceutical Preparations chemistry, Cosmetics administration & dosage, Dietary Supplements, Pharmaceutical Preparations administration & dosage
Published: 2008
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90. The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system.

Author: Mueller BK, Yamashita T, Schaffar G, and Mueller R
Subjects: Animals, Central Nervous System metabolism, Ephrin-A5 chemistry, Neurons metabolism, Signal Transduction, Central Nervous System embryology, Central Nervous System growth & development, Ephrin-A5 metabolism, Neurons cytology
Abstract: During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing neurites tipped with motile growth cones rely on guidance cues present in their local environment. These cues are detected by specific receptors expressed on growth cones and neurites and influence the trajectory of the growing fibres. Neurite growth, guidance, target innervation and synapse formation and maturation are the processes that occur predominantly but not exclusively during embryonic or early post-natal development in vertebrates. As a result, a functional neural network is established, which is usually remarkably stable. However, the stability of the neural network in higher vertebrates comes at an expensive price, i.e. the loss of any significant ability to regenerate injured or damaged neuronal connections in their central nervous system (CNS). Most importantly, neurite growth inhibitors prevent any regenerative growth of injured nerve fibres. Some of these inhibitors are associated with CNS myelin, others are found at the lesion site and in the scar tissue. Traumatic injuries in brain and spinal cord of mammals induce upregulation of embryonic inhibitory or repulsive guidance cues and their receptors on the neurites. An example for embryonic repulsive directional cues re-expressed at lesion sites in both the rat and human CNS is provided with repulsive guidance molecules, a new family of directional guidance cues.
Published: 2006
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91. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

Author: Behrends C, Langer CA, Boteva R, Böttcher UM, Stemp MJ, Schaffar G, Rao BV, Giese A, Kretzschmar H, Siegers K, and Hartl FU
Subjects: Chaperonins metabolism, DNA Repeat Expansion, Green Fluorescent Proteins analysis, HSP40 Heat-Shock Proteins metabolism, HSP70 Heat-Shock Proteins metabolism, Peptides metabolism, Protein Folding, Recombinant Fusion Proteins analysis, Repetitive Sequences, Amino Acid, Saccharomyces cerevisiae cytology, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae Proteins metabolism, Chaperonins physiology, Peptides chemistry
Abstract: Aberrant folding and fibrillar aggregation by polyglutamine (polyQ) expansion proteins are associated with cytotoxicity in Huntington's disease and other neurodegenerative disorders. Hsp70 chaperones have an inhibitory effect on fibril formation and can alleviate polyQ cytotoxicity. Here we show that the cytosolic chaperonin, TRiC, functions synergistically with Hsp70 in this process and is limiting in suppressing polyQ toxicity in a yeast model. In vitro reconstitution experiments revealed that TRiC, in cooperation with the Hsp70 system, promotes the assembly of polyQ-expanded fragments of huntingtin (Htt) into soluble oligomers of approximately 500 kDa. Similar oligomers were observed in yeast cells upon TRiC overexpression and were found to be benign, in contrast to conformationally distinct Htt oligomers of approximately 200 kDa, which accumulated at normal TRiC levels and correlated with inhibition of cell growth. We suggest that TRiC cooperates with the Hsp70 system as a key component in the cellular defense against amyloid-like protein misfolding.
Published: 2006
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92. Single particle detection and characterization of synuclein co-aggregation.

Author: Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, and Kretzschmar H
Subjects: Amyloid analysis, Binding Sites, Dimerization, Multiprotein Complexes analysis, Multiprotein Complexes chemistry, Multiprotein Complexes ultrastructure, Nerve Tissue Proteins analysis, Protein Binding, Synucleins, alpha-Synuclein, Amyloid chemistry, Amyloid ultrastructure, Nerve Tissue Proteins chemistry, Nerve Tissue Proteins ultrastructure, Spectrometry, Fluorescence methods
Abstract: Protein aggregation is the key event in a number of human diseases such as Alzheimer's and Parkinson's disease. We present a general method to quantify and characterize protein aggregates by dual-colour scanning for intensely fluorescent targets (SIFT). In addition to high sensitivity, this approach offers a unique opportunity to study co-aggregation processes. As the ratio of two fluorescently labelled components can be analysed for each aggregate separately in a homogeneous assay, the molecular composition of aggregates can be studied even in samples containing a mixture of different types of aggregates. Using this method, we could show that wild-type alpha-synuclein forms co-aggregates with a mutant variant found in familial Parkinson's disease. Moreover, we found a striking increase in aggregate formation at non-equimolar mixing ratios, which may have important therapeutic implications, as lowering the relative amount of aberrant protein may cause an increase of protein aggregation leading to adverse effects.
Published: 2005
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93. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.

Author: Schaffar G, Breuer P, Boteva R, Behrends C, Tzvetkov N, Strippel N, Sakahira H, Siegers K, Hayer-Hartl M, and Hartl FU
Subjects: Animals, CREB-Binding Protein, Cell Line, Tumor, Cell Nucleus metabolism, Exons, HSP70 Heat-Shock Proteins genetics, HSP70 Heat-Shock Proteins metabolism, Huntingtin Protein, Macromolecular Substances, Mice, Molecular Chaperones genetics, Molecular Chaperones metabolism, Mutation genetics, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, Neurodegenerative Diseases etiology, Neurodegenerative Diseases genetics, Neurodegenerative Diseases metabolism, Nuclear Proteins antagonists & inhibitors, Nuclear Proteins genetics, Nuclear Proteins metabolism, Peptides metabolism, Protein Conformation, Protein Folding, Saccharomyces cerevisiae, TATA-Box Binding Protein antagonists & inhibitors, TATA-Box Binding Protein genetics, TATA-Box Binding Protein metabolism, Trans-Activators antagonists & inhibitors, Trans-Activators genetics, Trans-Activators metabolism, Transcription Factors genetics, Transcription Factors metabolism, Nerve Tissue Proteins toxicity, Nuclear Proteins toxicity, Peptides genetics, Transcription Factors antagonists & inhibitors, Trinucleotide Repeat Expansion genetics
Abstract: The expression of polyglutamine-expanded mutant proteins in Huntington's disease and other neurodegenerative disorders is associated with the formation of intraneural inclusions. These aggregates could potentially cause cellular toxicity by sequestering essential proteins possessing normal polyQ repeats, including the transcription factors TBP and CBP. We show, in vitro and in cells, that monomers or small soluble oligomers of huntingtin exon1 accumulate in the nucleus and inhibit the function of TBP in a polyQ-dependent manner. FRET experiments indicate that these toxic forms are generated through a conformational rearrangement in huntingtin. Interaction of toxic huntingtin with the benign polyQ repeat of TBP structurally destabilizes the transcription factor, independent of the formation of insoluble coaggregates. Hsp70/Hsp40 chaperones interfere with the conformational change in mutant huntingtin and inhibit the deactivation of TBP. These results outline a molecular mechanism of cellular toxicity in polyQ disease and can explain the beneficial effects of molecular chaperones.
Published: 2004
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94. Roles of molecular chaperones in protein misfolding diseases.

Author: Barral JM, Broadley SA, Schaffar G, and Hartl FU
Subjects: Amyloid chemistry, Amyloid physiology, Chaperonin 60 genetics, Chaperonin 60 physiology, Chaperonins physiology, Cysteine Endopeptidases physiology, Cytosol physiology, Endoplasmic Reticulum physiology, Eye Proteins genetics, Eye Proteins physiology, GTP-Binding Proteins, Group II Chaperonins, HSP70 Heat-Shock Proteins physiology, HSP90 Heat-Shock Proteins physiology, Heat-Shock Proteins genetics, Heat-Shock Proteins physiology, Humans, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Models, Biological, Molecular Chaperones genetics, Multienzyme Complexes physiology, Mutation, Proteasome Endopeptidase Complex, Proteins physiology, Ubiquitins physiology, alpha-Crystallins genetics, alpha-Crystallins physiology, Disease etiology, Molecular Chaperones physiology, Protein Folding, Proteins chemistry
Abstract: Human misfolding diseases result from the failure of proteins to reach their active state or from the accumulation of aberrantly folded proteins. The mechanisms by which molecular chaperones influence the development of these diseases is beginning to be understood. Mutations that compromise the activity of chaperones lead to several rare syndromes. In contrast, the more frequent amyloid-related neurodegenerative diseases are caused by a gain of toxic function of misfolded proteins. Toxicity in these disorders may result from an imbalance between normal chaperone capacity and production of dangerous protein species. Increased chaperone expression can suppress the neurotoxicity of these molecules, suggesting possible therapeutic strategies.
Published: 2004
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95. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.

Author: Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, and Hartl FU
Subjects: Amino Acid Sequence, Amyloid ultrastructure, Chaperonin 60 metabolism, Exons, HSP40 Heat-Shock Proteins, Heat-Shock Proteins metabolism, Humans, Huntingtin Protein, Molecular Sequence Data, Nerve Tissue Proteins genetics, Nerve Tissue Proteins ultrastructure, Nuclear Proteins genetics, Nuclear Proteins ultrastructure, Peptide Fragments genetics, Peptide Fragments metabolism, Peptide Fragments ultrastructure, Peptides genetics, Protein Binding, Recombinant Fusion Proteins metabolism, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae metabolism, Trinucleotide Repeat Expansion, Amyloid metabolism, Chaperonins metabolism, Nerve Tissue Proteins metabolism, Nuclear Proteins metabolism, Peptides metabolism
Abstract: The deposition of protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by polyglutamine (polyQ) proteins. We analyzed the effects of the heat shock protein (Hsp) 70 chaperone system on the aggregation of fragments of huntingtin (htt) with expanded polyQ tracts. In vitro, Hsp70 and its cochaperone Hsp40 suppressed the assembly of htt into detergent-insoluble amyloid-like fibrils in an ATP-dependent manner and caused the formation of amorphous, detergent-soluble aggregates. The chaperones were most active in preventing fibrillization when added during the lag phase of the polymerization reaction. Similarly, coexpression of Hsp70 or Hsp40 with htt in yeast inhibited the formation of large, detergent-insoluble polyQ aggregates, resulting in the accumulation of detergent-soluble inclusions. Thus, the recently established potency of Hsp70 and Hsp40 to repress polyQ-induced neurodegeneration may be based on the ability of these chaperones to shield toxic forms of polyQ proteins and to direct them into nontoxic aggregates.
Published: 2000
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96. Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein.

Author: Pause A, Peterson B, Schaffar G, Stearman R, and Klausner RD
Subjects: Binding Sites, Elongin, Genetic Vectors, Peptide Mapping, Polymerase Chain Reaction, Protein Binding, SKP Cullin F-Box Protein Ligases, Schizosaccharomyces, Von Hippel-Lindau Tumor Suppressor Protein, Carrier Proteins metabolism, Cell Cycle Proteins metabolism, Cullin Proteins, Ligases, Peptide Synthases metabolism, Proteins metabolism, Transcription Factors metabolism, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases
Abstract: The yeast two-hybrid system is a powerful technique that detects interactions between two proteins and has been useful in identifying new binding partners. However, the system fails to detect protein-protein interactions that require the presence of additional components of a multisubunit complex. Here we demonstrate that the vector YIpDCE1 can be used to express elongins B and C in yeast, and that these proteins form a stable complex that interacts with the von Hippel-Lindau tumor-suppressor gene product (pVHL). Only when pVHL and elongins B and C (VBC) are present does an interaction with the cullin family member, hCUL-2, occur, forming the heterotetrameric pVHL/elongin BC/hCUL-2 complex. This system was then used to map the binding region of hCUL-2 for the VBC complex. The first amino-terminal 108 aa of hCUL-2 are necessary for interaction with the VBC complex. The elongin BC dimer acts as a bridge between pVHL and hCUL-2 because pVHL and hCUL-2 can form distinct complexes with elongins B and C. These results reveal a striking structural resemblance of pVHL/elongin BC/hCUL-2 complex with the E3-like ubiquitin ligase complex SKP1/Cullin/F-box protein with respect to protein composition and sites of interactions. Thus, it seems possible that pVHL/elongin BC/hCUL-2 complex will possess ubiquitin ligase activity targeting specific proteins for degradation by the proteasome.
Published: 1999
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