Search

Your search keyword '"Sbiera, Silviu"' showing total 400 results
Start Over Author "Sbiera, Silviu"
400 results on '"Sbiera, Silviu"'

51. Consecutive adrenal cushing´s syndrome and cushing´s disease in a patient with somatic CTNNB1, USP8, and NR3c1 mutations

Author

Detomas, Mario, primary, Altieri, Barbara, additional, Schlotelburg, Wiebke, additional, Appenzeller, Silke, additional, Schlaffer, Sven, additional, Coras, Roland, additional, Schirbel, Andreas, additional, Wild, Vanessa, additional, Kroiss, Matthias, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, and Deutschbein, Timo, additional

Published
2021
Full Text
View/download PDF

52. Case Report: Consecutive Adrenal Cushing’s Syndrome and Cushing’s Disease in a Patient With Somatic CTNNB1, USP8, and NR3C1 Mutations

Author

Detomas, Mario, primary, Altieri, Barbara, additional, Schlötelburg, Wiebke, additional, Appenzeller, Silke, additional, Schlaffer, Sven, additional, Coras, Roland, additional, Schirbel, Andreas, additional, Wild, Vanessa, additional, Kroiss, Matthias, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, and Deutschbein, Timo, additional

Published
2021
Full Text
View/download PDF

53. High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer

Author

Eckhardt, Carolin, primary, Sbiera, Iuliu, additional, Krebs, Markus, additional, Sbiera, Silviu, additional, Spahn, Martin, additional, Kneitz, Burkhard, additional, Joniau, Steven, additional, Fassnacht, Martin, additional, Kübler, Hubert, additional, Weigand, Isabel, additional, and Kroiss, Matthias, additional

Published
2021
Full Text
View/download PDF

54. Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer

Author

Faria, André M., Sbiera, Silviu, Ribeiro, Tamaya C., Soares, Iberê C., Mariani, Beatriz M.P., Freire, Daniel S., de Sousa, Gabriela R.V., Lerario, Antônio M., Ronchi, Cristina L., Deutschbein, Timo, Wakamatsu, Alda, Alves, Venancio A.F., Zerbini, Maria Claudia N., Mendonca, Berenice B., Fragoso, Maria Candida B.V., Latronico, Ana Claudia, Fassnacht, Martin, and Almeida, Madson Q.

Published
2015
Full Text
View/download PDF

55. Circulating microRNA Expression in Cushing's Syndrome

Author

Vetrivel, Sharmilee, Zhang, Ru, Engel, Mareen, Altieri, Barbara, Braun, Leah, Osswald, Andrea, Bidlingmaier, Martin, Fassnacht, Martin, Beuschlein, Felix, Reincke, Martin, Chen, Alon, Sbiera, Silviu, Riester, Anna, Vetrivel, Sharmilee, Zhang, Ru, Engel, Mareen, Altieri, Barbara, Braun, Leah, Osswald, Andrea, Bidlingmaier, Martin, Fassnacht, Martin, Beuschlein, Felix, Reincke, Martin, Chen, Alon, Sbiera, Silviu, and Riester, Anna

Abstract

Context Cushing's syndrome (CS) is a rare disease of endogenous hypercortisolism associated with high morbidity and mortality. Diagnosis and classification of CS is still challenging. Objective Circulating microRNAs (miRNAs) are minimally invasive diagnostic markers. Our aim was to characterize the circulating miRNA profiles of CS patients and to identify distinct profiles between the two major CS subtypes. Methods We included three groups of patients from the German Cushing's registry: ACTH-independent CS (Cortisol-Producing-Adenoma; CPA), ACTH-dependent pituitary CS (Cushing's Disease; CD), and patients in whom CS had been ruled out (controls). Profiling of miRNAs was performed by next-generation-sequencing (NGS) in serum samples of 15 CS patients (each before and after curative surgery) and 10 controls. Significant miRNAs were first validated by qPCR in the discovery cohort and then in an independent validation cohort of 20 CS patients and 11 controls. Results NGS identified 411 circulating miRNAs. Differential expression of 14 miRNAs were found in the pre- and postoperative groups. qPCR in the discovery cohort validated 5 of the significant miRNAs from the preoperative group analyses. Only, miR-182-5p was found to be significantly upregulated in the CD group of the validation cohort. Comparing all CS samples as a group with the controls did not reveal any significant differences in expression. Outcome In conclusion, our study identified miR-182-5p as a possible biomarker for CD, which has to be validated in a prospective cohort. Furthermore, our results suggest that presence or absence of ACTH might be at least as relevant for miRNA expression as hypercortisolism itself.

Published
2021

56. PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser\(^{114}\) phosphorylation

Author

Weigand, Isabel, Ronchi, Cristina L., Vanselow, Jens T., Bathon, Kerstin, Lenz, Kerstin, Herterich, Sabine, Schlosser, Andreas, Kroiss, Matthias, Fassnacht, Martin, Calebiro, Davide, and Sbiera, Silviu

Subjects
ddc:610
Abstract

Mutations in the PRKACA gene are the most frequent cause of cortisol-producing adrenocortical adenomas leading to Cushing’s syndrome. PRKACA encodes for the catalytic subunit α of protein kinase A (PKA). We already showed that PRKACA mutations lead to impairment of regulatory (R) subunit binding. Furthermore, PRKACA mutations are associated with reduced RIIβ protein levels; however, the mechanisms leading to reduced RIIβ levels are presently unknown. Here, we investigate the effects of the most frequent PRKACA mutation, L206R, on regulatory subunit stability. We find that Ser\(^{114}\) phosphorylation of RIIβ is required for its degradation, mediated by caspase 16. Last, we show that the resulting reduction in RIIβ protein levels leads to increased cortisol secretion in adrenocortical cells. These findings reveal the molecular mechanisms and pathophysiological relevance of the R subunit degradation caused by PRKACA mutations, adding another dimension to the deregulation of PKA signaling caused by PRKACA mutations in adrenal Cushing’s syndrome.

Published
2021

57. Case Report: Consecutive Adrenal Cushing’s Syndrome and Cushing’s Disease in a Patient With Somatic CTNNB1, USP8, and NR3C1 Mutations

Author

Detomas, Mario, Altieri, Barbara, Schlötelburg, Wiebke, Appenzeller, Silke, Schlaffer, Sven, Coras, Roland, Schirbel, Andreas, Wild, Vanessa, Kroiss, Matthias, Sbiera, Silviu, Fassnacht, Martin, and Deutschbein, Timo

Subjects
Endocrinology, Diabetes and Metabolism, ddc:610
Abstract

The occurrence of different subtypes of endogenous Cushing’s syndrome (CS) in single individuals is extremely rare. We here present the case of a female patient who was successfully cured from adrenal CS 4 years before being diagnosed with Cushing’s disease (CD). The patient was diagnosed at the age of 50 with ACTH-independent CS and a left-sided adrenal adenoma, in January 2015. After adrenalectomy and histopathological confirmation of a cortisol-producing adrenocortical adenoma, biochemical hypercortisolism and clinical symptoms significantly improved. However, starting from 2018, the patient again developed signs and symptoms of recurrent CS. Subsequent biochemical and radiological workup suggested the presence of ACTH-dependent CS along with a pituitary microadenoma. The patient underwent successful transsphenoidal adenomectomy, and both postoperative adrenal insufficiency and histopathological workup confirmed the diagnosis of CD. Exome sequencing excluded a causative germline mutation but showed somatic mutations of the β-catenin protein gene (CTNNB1) in the adrenal adenoma, and of both the ubiquitin specific peptidase 8 (USP8) and the glucocorticoid receptor (NR3C1) genes in the pituitary adenoma. In conclusion, our case illustrates that both ACTH-independent and ACTH-dependent CS may develop in a single individual even without evidence for a common genetic background.

Published
2021

59. Consecutive development of adrenal Cushing´s syndrome and Cushing´s disease in a female patient with somatic CTNNB1, USP8, and NR3C1 mutations

Author

Detomas, Mario, primary, Altieri, Barbara, additional, Schlötelburg, Wiebke, additional, Appenzeller, Silke, additional, Sven-Martin, Schlaffer, additional, Roland, Coras, additional, Andreas, Schirbel, additional, Wild, Vanessa, additional, Kroiss, Matthias, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, and Deutschbein, Timo, additional

Published
2021
Full Text
View/download PDF

60. Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas

Author

Weigand, Isabel, Ronchi, Cristina L., Rizk-Rabin, Marthe, Dalmazi, Guido Di, Wild, Vanessa, Bathon, Kerstin, Rubin, Beatrice, Calebiro, Davide, Beuschlein, Felix, Bertherat, Jérôme, Fassnacht, Martin, Sbiera, Silviu, Comprehensive Cancer Center Mainfranken, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute of Pharmacology and Toxicology, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU)-University Hospital of Würzburg-Rudolf Virchow Center for Experimental Biomedicine, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität München (LMU), Department of Medicine I, University Hospital, University Hospital of Würzburg, University of Zurich, Sbiera, Silviu, Weigand, Isabel, Ronchi, Cristina L, Rizk-Rabin, Marthe, Di Dalmazi, Guido, Wild, Vanessa, Bathon, Kerstin, Rubin, Beatrice, Calebiro, Davide, Beuschlein, Felix, Bertherat, Jérôme, and Fassnacht, Martin

Subjects
ddc:616, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, 1000 Multidisciplinary, Gene Expression Profiling, [SDV]Life Sciences [q-bio], Science, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Article, Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit, Immunohistochemistry Kinases Cushing PKA, Adrenal Glands, Adrenocortical Adenoma, Humans, Medicine, ComputingMilieux_MISCELLANEOUS
Abstract

Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two catalytic and two regulatory subunits with the latter inhibiting PKA activity. The human genome encodes three different PKA catalytic subunits and four different regulatory subunits that are preferentially expressed in different organs. In normal adrenal glands all regulatory subunits are expressed, while CPA exhibit reduced protein levels of the regulatory subunit IIβ. In this study, we linked for the first time the loss of RIIβ protein levels to the PRKACA mutation status and found the down-regulation of RIIβ to arise post-transcriptionally. We further found the PKA subunit expression pattern of different tumours is also present in the zones of the normal adrenal cortex and demonstrate that the different PKA subunits have a differential expression pattern in each zone of the normal adrenal gland, indicating potential specific roles of these subunits in the regulation of different hormones secretion.

Published
2017

61. Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushingʼs Syndrome

Author

Beuschlein, Felix, Fassnacht, Martin, Assié, Guillaume, Calebiro, Davide, Stratakis, Constantine A., Osswald, Andrea, Ronchi, Cristina L., Wieland, Thomas, Sbiera, Silviu, Faucz, Fabio R., Schaak, Katrin, Schmittfull, Anett, Schwarzmayr, Thomas, Barreau, Olivia, Vezzosi, Delphine, Rizk-Rabin, Marthe, Zabel, Ulrike, Szarek, Eva, Salpea, Paraskevi, Forlino, Antonella, Vetro, Annalisa, Zuffardi, Orsetta, Kisker, Caroline, Diener, Susanne, Meitinger, Thomas, Lohse, Martin J., Reincke, Martin, Bertherat, Jérome, Strom, Tim M., and Allolio, Bruno

Published
2014
Full Text
View/download PDF

62. Circulating microRNA Expression in Cushing’s Syndrome

Author

Vetrivel, Sharmilee, primary, Zhang, Ru, additional, Engel, Mareen, additional, Altieri, Barbara, additional, Braun, Leah, additional, Osswald, Andrea, additional, Bidlingmaier, Martin, additional, Fassnacht, Martin, additional, Beuschlein, Felix, additional, Reincke, Martin, additional, Chen, Alon, additional, Sbiera, Silviu, additional, and Riester, Anna, additional

Published
2021
Full Text
View/download PDF

64. Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

Author

Lopez, Juan Pablo, primary, Brivio, Elena, additional, Santambrogio, Alice, additional, De Donno, Carlo, additional, Kos, Aron, additional, Peters, Miriam, additional, Rost, Nicolas, additional, Czamara, Darina, additional, Brückl, Tanja M., additional, Roeh, Simone, additional, Pöhlmann, Max L., additional, Engelhardt, Clara, additional, Ressle, Andrea, additional, Stoffel, Rainer, additional, Tontsch, Alina, additional, Villamizar, Javier M., additional, Reincke, Martin, additional, Riester, Anna, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, Mayberg, Helen S., additional, Craighead, W. Edward, additional, Dunlop, Boadie W., additional, Nemeroff, Charles B., additional, Schmidt, Mathias V., additional, Binder, Elisabeth B., additional, Theis, Fabian J., additional, Beuschlein, Felix, additional, Andoniadou, Cynthia L., additional, and Chen, Alon, additional

Published
2021
Full Text
View/download PDF

65. Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations

Author

Reincke, Martin, primary, Albani, Adriana, additional, Assie, Guillaume, additional, Bancos, Irina, additional, Brue, Thierry, additional, Buchfelder, Michael, additional, Chabre, Olivier, additional, Ceccato, Filippo, additional, Daniele, Andrea, additional, Detomas, Mario, additional, Di Dalmazi, Guido, additional, Elenkova, Atanaska, additional, Findling, James, additional, Grossman, Ashley B, additional, Gomez-Sanchez, Celso E, additional, Heaney, Anthony P, additional, Honegger, Juergen, additional, Karavitaki, Niki, additional, Lacroix, Andre, additional, Laws, Edward R, additional, Losa, Marco, additional, Murakami, Masanori, additional, Newell-Price, John, additional, Pecori Giraldi, Francesca, additional, Pérez‐Rivas, Luis G, additional, Pivonello, Rosario, additional, Rainey, William E, additional, Sbiera, Silviu, additional, Schopohl, Jochen, additional, Stratakis, Constantine A, additional, Theodoropoulou, Marily, additional, van Rossum, Elisabeth F C, additional, Valassi, Elena, additional, Zacharieva, Sabina, additional, Rubinstein, German, additional, and Ritzel, Katrin, additional

Published
2021
Full Text
View/download PDF

66. Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma

Author

Liang, Raimunde, Weigand, Isabel, Lippert, Juliane, Kircher, Stefan, Altieri, Barbara, Steinhauer, Sonja, Hantel, Constanze, Rost, Simone, Rosenwald, Andreas, Kroiss, Matthias, Fassnacht, Martin, Sbiera, Silviu, Ronchi, Cristina L, University of Zurich, and Ronchi, Cristina L

Subjects
2712 Endocrinology, Diabetes and Metabolism, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health
Published
2020

67. Interplay between glucocorticoids and tumor-infiltrating lymphocytes on the prognosis of adrenocortical carcinoma

Author

Landwehr, Laura-Sophie, Altieri, Barbara, Schreiner, Jochen, Sbiera, Iuliu, Weigand, Isabel, Kroiss, Matthias, Fassnacht, Martin, and Sbiera, Silviu

Subjects
ddc:610
Abstract

Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy. Tumor-related glucocorticoid excess is present in similar to 60% of patients and associated with particularly poor prognosis. Results of first clinical trials using immune checkpoint inhibitors were heterogeneous. Here we characterize tumor-infiltrating T lymphocytes (TILs) in ACC in association with glucocorticoids as potential explanation for resistance to immunotherapy. Methods We performed immunofluorescence analysis to visualize tumor-infiltrating T cells (CD3\(^+\)), T helper cells (CD3\(^+\)CD4\(^+\)), cytotoxic T cells (CD3\(^+\)CD8\(^+\)) and regulatory T cells (Tregs; CD3\(^+\)CD4\(^+\)FoxP3\(^+\)) in 146 ACC tissue specimens (107 primary tumors, 16 local recurrences, 23 metastases). Quantitative data of immune cell infiltration were correlated with clinical data (including glucocorticoid excess). Results 86.3% of ACC specimens showed tumor infiltrating T cells (7.7 cells/high power field (HPF)), including T helper (74.0%, 6.7 cells/HPF), cytotoxic T cells (84.3%, 5.7 cells/HPF) and Tregs (49.3%, 0.8 cells/HPF). The number of TILs was associated with better overall survival (HR for death: 0.47, 95% CI 0.25 to 0.87), which was true for CD4\(^+\)- and CD8\(^+\) subpopulations as well. In localized, non-metastatic ACC, the favorable impact of TILs on overall and recurrence-free survival was manifested even independently of ENSAT (European Network for the Study of Adrenal Tumors) stage, resection status and Ki67 index. T helper cells were negatively correlated with glucocorticoid excess (Phi=-0.290, p=0.009). Patients with glucocorticoid excess and low TILs had a particularly poor overall survival (27 vs. 121 months in patients with TILs without glucocorticoid excess). Conclusion Glucocorticoid excess is associated with T cell depletion and unfavorable prognosis. To reactivate the immune system in ACC by checkpoint inhibitors, an inhibition of adrenal steroidogenesis might be pivotal and should be tested in prospective studies.

Published
2020

68. The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the Spotlight

Author

Sbiera, Silviu, Kunz, Meik, Weigand, Isabel, Deutschbein, Timo, Dandekar, Thomas, and Fassnacht, Martin

Subjects
Medizinische Fakultät, pathogenesis, somatic mutations, deubiquitinases, ddc:610, Cushing’s disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract

Cushing&rsquo, s disease (CD) is a rare condition caused by adrenocorticotropic hormone (ACTH)-producing adenomas of the pituitary, which lead to hypercortisolism that is associated with high morbidity and mortality. Treatment options in case of persistent or recurrent disease are limited, but new insights into the pathogenesis of CD are raising hope for new therapeutic avenues. Here, we have performed a meta-analysis of the available sequencing data in CD to create a comprehensive picture of CD&rsquo, s genetics. Our analyses clearly indicate that somatic mutations in the deubiquitinases are the key drivers in CD, namely USP8 (36.5%) and USP48 (13.3%). While in USP48 only Met415 is affected by mutations, in USP8 there are 26 different mutations described. However, these different mutations are clustering in the same hotspot region (affecting in 94.5% of cases Ser718 and Pro720). In contrast, pathogenic variants classically associated with tumorigenesis in genes like TP53 and BRAF are also present in CD but with low incidence (12.5% and 7%). Importantly, several of these mutations might have therapeutic potential as there are drugs already investigated in preclinical and clinical setting for other diseases. Furthermore, network and pathway analyses of all somatic mutations in CD suggest a rather unified picture hinting towards converging oncogenic pathways.

Published
2019
Full Text
View/download PDF

71. RNA Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights

Author

Di Dalmazi, Guido, primary, Altieri, Barbara, additional, Scholz, Claus, additional, Sbiera, Silviu, additional, Luconi, Michaela, additional, Waldman, Jens, additional, Kastelan, Darko, additional, Ceccato, Filippo, additional, Chiodini, Iacopo, additional, Arnaldi, Giorgio, additional, Riester, Anna, additional, Osswald, Andrea, additional, Beuschlein, Felix, additional, Sauer, Sascha, additional, Fassnacht, Martin, additional, Appenzeller, Silke, additional, and Ronchi, Cristina L, additional

Published
2020
Full Text
View/download PDF

72. Differential adrenal toxicity of SOAT1-inhibitors

Author

Weigand, Isabel, primary, Sbiera, Silviu, additional, Kendl, Sabine, additional, Hanna, Urlaub, additional, Constanze, Hantel, additional, Katja, Kiseljak-Vassiliades, additional, Margaret, E Wierman, additional, Fassnacht, Martin, additional, and Kroiss, Matthias, additional

Published
2020
Full Text
View/download PDF

73. Cytochrome P450 (CYP) 2W1 affect steroid secretion in adrenocortical cell line and tumor tissues

Author

Altieri, Barbara, primary, Sbiera, Silviu, additional, Weigand, Isabel, additional, Volante, Marco, additional, Steinhauer, Sonja, additional, Lorey, Antonia, additional, Kendl, Sabine, additional, Kurlbaum, Max, additional, Herterich, Sabine, additional, Della, Casa Silvia, additional, Colao, Annamaria, additional, Terzolo, Massimo, additional, Kroiss, Matthias, additional, Fassnacht, Martin, additional, and Ronchi, Cristina, additional

Published
2020
Full Text
View/download PDF

76. RNA-sequencing of adrenocortical tumors reveals novel pathogenetic insights

Author

Di, Dalmazi Guido, primary, Altieri, Barbara, additional, Scholz, Claus, additional, Sbiera, Silviu, additional, Luconi, Michaela, additional, Waldmann, Jens, additional, Kastelan, Darko, additional, Ceccato, Filippo, additional, Chiodini, Iacopo, additional, Arnaldi, Giorgio, additional, Osswald, Andrea, additional, Reincke, Martin, additional, Beuschlein, Felix, additional, Sauer, Sascha, additional, Fassnacht, Martin, additional, Appenzeller, Silke, additional, and Ronchi, Cristina, additional

Published
2020
Full Text
View/download PDF

77. Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study

Author

Weigand, Isabel, primary, Altieri, Barbara, additional, Lacombe, Amanda M F, additional, Basile, Vittoria, additional, Kircher, Stefan, additional, Landwehr, Laura-Sophie, additional, Schreiner, Jochen, additional, Zerbini, Maria C N, additional, Ronchi, Cristina L, additional, Megerle, Felix, additional, Berruti, Alfredo, additional, Canu, Letizia, additional, Volante, Marco, additional, Paiva, Isabel, additional, Della Casa, Silvia, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, Fragoso, Maria Candida B V, additional, Terzolo, Massimo, additional, and Kroiss, Matthias, additional

Published
2020
Full Text
View/download PDF

81. Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma

Author

Liang, Raimunde, primary, Weigand, Isabel, additional, Lippert, Juliane, additional, Kircher, Stefan, additional, Altieri, Barbara, additional, Steinhauer, Sonja, additional, Hantel, Constanze, additional, Rost, Simone, additional, Rosenwald, Andreas, additional, Kroiss, Matthias, additional, Fassnacht, Martin, additional, Sbiera, Silviu, additional, and Ronchi, Cristina L., additional

Published
2020
Full Text
View/download PDF

82. SUN-211 Active Steroid Hormone Synthesis Renders Adrenocortical Cells Highly Susceptible to Type II Ferroptosis Induction

Author

Weigand, Isabel, primary, Schreiner, Jochen, primary, Roehrig, Florian, primary, Sun, Na, primary, Laura-Sophie, Landwehr, primary, Urlaub, Hanna, primary, Kiseljak-Vassiliades, Katja, primary, Wierman, Margaret E, primary, Angeli, José Pedro Friedmann, primary, Walch, Axel K, primary, Sbiera, Silviu, primary, Fassnacht, Martin, primary, and Kroiss, Matthias, primary

Published
2020
Full Text
View/download PDF

84. Cancer-testis Antigen FATE1 Expression in Adrenocortical Tumors Is Associated with A Pervasive Autoimmune Response and Is A Marker of Malignancy in Adult, but Not Children, ACC

Author

Doghman-Bouguerra, Mabrouka, primary, Finetti, Pascal, additional, Durand, Nelly, additional, Parise, Ivy Zortéa S., additional, Sbiera, Silviu, additional, Cantini, Giulia, additional, Canu, Letizia, additional, Hescot, Ségolène, additional, Figueiredo, Mirna M. O., additional, Komechen, Heloisa, additional, Sbiera, Iuliu, additional, Nesi, Gabriella, additional, Paci, Angelo, additional, Al Ghuzlan, Abir, additional, Birnbaum, Daniel, additional, Baudin, Eric, additional, Luconi, Michaela, additional, Fassnacht, Martin, additional, Figueiredo, Bonald C., additional, Bertucci, François, additional, and Lalli, Enzo, additional

Published
2020
Full Text
View/download PDF

85. Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study

Author

Altieri, Barbara, primary, Sbiera, Silviu, additional, Herterich, Sabine, additional, De Francia, Silvia, additional, Della Casa, Silvia, additional, Calabrese, Anna, additional, Pontecorvi, Alfredo, additional, Quinkler, Marcus, additional, Kienitz, Tina, additional, Mannelli, Massimo, additional, Canu, Letizia, additional, Angelousi, Anna, additional, Chortis, Vasileios, additional, Kroiss, Matthias, additional, Terzolo, Massimo, additional, Fassnacht, Martin, additional, and Ronchi, Cristina L., additional

Published
2020
Full Text
View/download PDF

87. Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging

Author

Sun, Na, primary, Kunzke, Thomas, additional, Sbiera, Silviu, additional, Kircher, Stefan, additional, Feuchtinger, Annette, additional, Aichler, Michaela, additional, Herterich, Sabine, additional, Ronchi, Cristina L, additional, Weigand, Isabel, additional, Schlegel, Nicolas, additional, Waldmann, Jens, additional, Candida Villares Fragoso, Maria, additional, Whitsett, Timothy G, additional, Gill, Anthony J, additional, Fassnacht, Martin, additional, Walch, Axel, additional, and Kroiss, Matthias, additional

Published
2019
Full Text
View/download PDF

88. Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma

Author

Assié, Guillaume, primary, Jouinot, Anne, additional, Fassnacht, Martin, additional, Libé, Rossella, additional, Garinet, Simon, additional, Jacob, Louis, additional, Hamzaoui, Nadim, additional, Neou, Mario, additional, Sakat, Julien, additional, de La Villéon, Bruno, additional, Perlemoine, Karine, additional, Ragazzon, Bruno, additional, Sibony, Mathilde, additional, Tissier, Frédérique, additional, Gaujoux, Sébastien, additional, Dousset, Bertrand, additional, Sbiera, Silviu, additional, Ronchi, Cristina L., additional, Kroiss, Matthias, additional, Korpershoek, Esther, additional, De Krijger, Ronald, additional, Waldmann, Jens, additional, Quinkler, Marcus, additional, Haissaguerre, Magalie, additional, Tabarin, Antoine, additional, Chabre, Olivier, additional, Luconi, Michaela, additional, Mannelli, Massimo, additional, Groussin, Lionel, additional, Bertagna, Xavier, additional, Baudin, Eric, additional, Amar, Laurence, additional, Coste, Joel, additional, Beuschlein, Felix, additional, and Bertherat, Jérôme, additional

Published
2019
Full Text
View/download PDF

89. Driver mutations in USP8 wild-type Cushing's disease

Author

Sbiera, Silviu, Perez-Rivas, Luis G., Taranets, Lyudmyla, Weigand, Isabel, Flitsch, Joerg, Graf, E., Hermus, A.R.M.M., Theodoropoulou, Marily, Fassnacht, M., Sbiera, Silviu, Perez-Rivas, Luis G., Taranets, Lyudmyla, Weigand, Isabel, Flitsch, Joerg, Graf, E., Hermus, A.R.M.M., Theodoropoulou, Marily, and Fassnacht, M.

Abstract

Contains fulltext : 209658.pdf (publisher's version ) (Open Access)

Published
2019

90. Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma

Author

Assié, Guillaume, Jouinot, Anne, Fassnacht, Martin, Libé, Rossella, Garinet, Simon, Jacob, Louis, Hamzaoui, Nadim, Neou, Mario, Sakat, Julien, De La Villeón, Bruno, Perlemoine, Karine, Ragazzon, Bruno, Sibony, Mathilde, Tissier, Frédérique, Gaujoux, Sébastien, Dousset, Bertrand, Sbiera, Silviu, Ronchi, Cristina L., Kroiss, Matthias, Korpershoek, Esther, De Krijger, Ronald, Waldmann, Jens, Quinkler, Marcus, Haissaguerre, Magalie, Tabarin, Antoine, Chabre, Olivier, Luconi, Michaela, Mannelli, Massimo, Groussin, Lionel, Bertagna, Xavier, Baudin, Eric, Amar, Laurence, Coste, Joel, Beuschlein, Felix, Bertherat, Jérôme, Assié, Guillaume, Jouinot, Anne, Fassnacht, Martin, Libé, Rossella, Garinet, Simon, Jacob, Louis, Hamzaoui, Nadim, Neou, Mario, Sakat, Julien, De La Villeón, Bruno, Perlemoine, Karine, Ragazzon, Bruno, Sibony, Mathilde, Tissier, Frédérique, Gaujoux, Sébastien, Dousset, Bertrand, Sbiera, Silviu, Ronchi, Cristina L., Kroiss, Matthias, Korpershoek, Esther, De Krijger, Ronald, Waldmann, Jens, Quinkler, Marcus, Haissaguerre, Magalie, Tabarin, Antoine, Chabre, Olivier, Luconi, Michaela, Mannelli, Massimo, Groussin, Lionel, Bertagna, Xavier, Baudin, Eric, Amar, Laurence, Coste, Joel, Beuschlein, Felix, and Bertherat, Jérôme

Published
2019

91. Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma

Author

Pathologie patiënten zorg, Pathologie Pathologen staf, Assié, Guillaume, Jouinot, Anne, Fassnacht, Martin, Libé, Rossella, Garinet, Simon, Jacob, Louis, Hamzaoui, Nadim, Neou, Mario, Sakat, Julien, De La Villeón, Bruno, Perlemoine, Karine, Ragazzon, Bruno, Sibony, Mathilde, Tissier, Frédérique, Gaujoux, Sébastien, Dousset, Bertrand, Sbiera, Silviu, Ronchi, Cristina L., Kroiss, Matthias, Korpershoek, Esther, De Krijger, Ronald, Waldmann, Jens, Quinkler, Marcus, Haissaguerre, Magalie, Tabarin, Antoine, Chabre, Olivier, Luconi, Michaela, Mannelli, Massimo, Groussin, Lionel, Bertagna, Xavier, Baudin, Eric, Amar, Laurence, Coste, Joel, Beuschlein, Felix, Bertherat, Jérôme, Pathologie patiënten zorg, Pathologie Pathologen staf, Assié, Guillaume, Jouinot, Anne, Fassnacht, Martin, Libé, Rossella, Garinet, Simon, Jacob, Louis, Hamzaoui, Nadim, Neou, Mario, Sakat, Julien, De La Villeón, Bruno, Perlemoine, Karine, Ragazzon, Bruno, Sibony, Mathilde, Tissier, Frédérique, Gaujoux, Sébastien, Dousset, Bertrand, Sbiera, Silviu, Ronchi, Cristina L., Kroiss, Matthias, Korpershoek, Esther, De Krijger, Ronald, Waldmann, Jens, Quinkler, Marcus, Haissaguerre, Magalie, Tabarin, Antoine, Chabre, Olivier, Luconi, Michaela, Mannelli, Massimo, Groussin, Lionel, Bertagna, Xavier, Baudin, Eric, Amar, Laurence, Coste, Joel, Beuschlein, Felix, and Bertherat, Jérôme

Published
2019

92. ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas

Author

Laufs, Valeria, Altieri, Barbara, Sbiera, Silviu, Kircher, Stefan, Steinhauer, Sonja, Beuschlein, Felix, Quinkler, Marcus, Willenberg, Holger S, Rosenwald, Andreas, Fassnacht, Martin, Ronchi, Cristina L, University of Zurich, and Ronchi, Cristina L

Subjects
2712 Endocrinology, Diabetes and Metabolism, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1310 Endocrinology
Published
2018

93. Driver mutations in USP8 wild-type Cushing’s disease

Author

Sbiera, Silviu, primary, Perez-Rivas, Luis Gustavo, additional, Taranets, Lyudmyla, additional, Weigand, Isabel, additional, Flitsch, Jörg, additional, Graf, Elisabeth, additional, Monoranu, Camelia-Maria, additional, Saeger, Wolfgang, additional, Hagel, Christian, additional, Honegger, Jürgen, additional, Assie, Guillaume, additional, Hermus, Ad R, additional, Stalla, Günter K, additional, Herterich, Sabine, additional, Ronchi, Cristina L, additional, Deutschbein, Timo, additional, Reincke, Martin, additional, Strom, Tim M, additional, Popov, Nikita, additional, Theodoropoulou, Marily, additional, and Fassnacht, Martin, additional

Published
2019
Full Text
View/download PDF

94. Cyclin dependent kinase 4 as promising drug target in adrenocortical carcinoma

Author

Liang, Raimunde, primary, Weigand, Isabel, additional, Sbiera, Silviu, additional, Kircher, Stefan, additional, Lippert, Juliane, additional, Altieri, Barbara, additional, Steinhauer, Sonja, additional, Hantel, Constanze, additional, Rost, Simone, additional, Rosenwald, Andreas, additional, Kroiss, Matthias, additional, Fassnacht, Martin, additional, and Ronchi, Cristina, additional

Published
2019
Full Text
View/download PDF

97. SUN-350 Sterol-O-Acyl Transferase 1 Protein Expression Alone Is Not Sufficient to Predict Response to Mitotane Treatment in Adrenocortical Carcinoma

Author

Weigand, Isabel, primary, Altieri, Barbara, additional, Ferreira, Amanda, additional, Basile, Vittoria, additional, Landwehr, Laura-Sophie, additional, Ronchi, Cristina, additional, Schreiner, Jochen, additional, Megerle, Felix, additional, Berruti, Alfredo, additional, Canu, Letizia, additional, Volante, Marco, additional, Paiva, Isabel, additional, Della Casa, Silvia, additional, Sbiera, Silviu, additional, Fassnacht, Martin, additional, Fragoso, Maria, additional, Terzolo, Massimo, additional, and Kroiss, Matthias, additional

Published
2019
Full Text
View/download PDF

99. Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease

Author

Weigand, Isabel, primary, Knobloch, Lisanne, additional, Flitsch, Jörg, additional, Saeger, Wolfgang, additional, Monoranu, Camelia M, additional, Höfner, Kerstin, additional, Herterich, Sabine, additional, Rotermund, Roman, additional, Ronchi, Cristina L, additional, Buchfelder, Michael, additional, Glatzel, Markus, additional, Hagel, Christian, additional, Fassnacht, Martin, additional, Deutschbein, Timo, additional, and Sbiera, Silviu, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results