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318 results on '"Savini, Vincenzo"'

52. Successful salvage therapy with Daptomycin for osteomyelitis caused by methicillin-resistant Staphylococcus aureus in a renal transplant recipient with Fabry-Anderson disease

Author

Polilli Ennio, Ursini Tamara, Mazzotta Elena, Sozio Federica, Savini Vincenzo, D'Antonio Domenico, Barbato Michelino, Consorte Augusta, and Parruti Giustino

Subjects
Methicillin-resistant Staphylococcus aureus, Osteomyelitis, Daptomycin, Salvage therapy, Antibiotic therapy, Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Abstract Daptomycin is licensed in adults for the management of Staphylococcus aureus methicillin-resistant infections, including bone and skin complicated infections. We describe for the first time its use in a renal transplant recipient for Fabry-Anderson Disease with right heel osteomyelitis. The patient was unresponsive to first-line Teicoplanin and second-line Tigecycline, whereas he was successfully treated with third-line Daptomycin monotherapy at 4 mg/Kg/qd for 4 weeks. Local debridement was performed in advance of each line of treatment.

Published
2012
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53. Phenotypic and genotypic characterization of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis: Genome diversity, biofilm formation, and virulence

Author

Fiscarelli Ersilia, Verginelli Fabio, Gherardi Giovanni, Crocetta Valentina, Pomponio Stefano, Pompilio Arianna, Dicuonzo Giordano, Savini Vincenzo, D'Antonio Domenico, and Di Bonaventura Giovanni

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Stenotrophomonas maltophilia is emerging as one of the most frequently found bacteria in cystic fibrosis (CF) patients. In the present study, phenotypic and genotypic traits of a set of 98 isolates of S. maltophilia obtained from clinical (CF and non-CF patients) and environmental sources were comparatively evaluated. Results S. maltophilia exhibited a high level of genomic diversity in both CF and non-CF group, thus possibly allowing this bacterium to expand its pathogenic potentials. Strains sharing the same pulsotype infected different patients, thus likely indicating the occurrence of clonal spread or acquisition by a common source. CF isolates differed greatly in some phenotypic traits among each other and also when compared with non-CF isolates, demonstrating increased mean generation time and susceptibility to oxidative stress, but reduced ability in forming biofilm. Furthermore, in CF isolates flagella- and type IV pili-based motilities were critical for biofilm development, although not required for its initiation. Sequential isogenic strains isolated from the same CF patient displayed heterogeneity in biofilm and other phenotypic traits during the course of chronic infection. CF and non-CF isolates showed comparable virulence in a mouse model of lung infection. Conclusions Overall, the phenotypic differences observed between CF and non-CF isolates may imply different selective conditions and persistence (adaptation) mechanisms in a hostile and heterogeneous environment such as CF lung. Molecular elucidation of these mechanisms will be essential to better understand the selective adaptation in CF airways in order to design improved strategies useful to counteract and eradicate S. maltophilia infection.

Published
2011
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54. Adhesion to and biofilm formation on IB3-1 bronchial cells by Stenotrophomonas maltophilia isolates from cystic fibrosis patients

Author

Petrucca Andrea, Nicoletti Mauro, Confalone Pamela, Crocetta Valentina, Pompilio Arianna, Guarnieri Simone, Fiscarelli Ersilia, Savini Vincenzo, Piccolomini Raffaele, and Di Bonaventura Giovanni

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Stenotrophomonas maltophilia has recently gained considerable attention as an important emerging pathogen in cystic fibrosis (CF) patients. However, the role of this microorganism in the pathophysiology of CF lung disease remains largely unexplored. In the present study for the first time we assessed the ability of S. maltophilia CF isolates to adhere to and form biofilm in experimental infection experiments using the CF-derived bronchial epithelial IB3-1cell line. The role of flagella on the adhesiveness of S. maltophilia to IB3-1 cell monolayers was also assessed by using fliI mutant derivative strains. Results All S. maltophilia CF isolates tested in the present study were able, although at different levels, to adhere to and form biofilm on IB3-1 cell monolayers. Scanning electron and confocal microscopy revealed S. maltophilia structures typical of biofilm formation on bronchial IB3-1 cells. The loss of flagella significantly (P < 0.001) decreased bacterial adhesiveness, if compared to that of their parental flagellated strains. S. maltophilia CF isolates were also able to invade IB3-1 cells, albeit at a very low level (internalization rate ranged from 0.01 to 4.94%). Pre-exposure of IB3-1 cells to P. aeruginosa PAO1 significantly increased S. maltophilia adhesiveness. Further, the presence of S. maltophilia negatively influenced P. aeruginosa PAO1 adhesiveness. Conclusions The main contribution of the present study is the finding that S. maltophilia is able to form biofilm on and invade CF-derived IB3-1 bronchial epithelial cells, thus posing a rationale for the persistence and the systemic spread of this opportunistic pathogen in CF patients. Experiments using in vivo models which more closely mimic CF pulmonary tissues will certainly be needed to validate the relevance of our results.

Published
2010
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55. The Diverse Faces of Bacillus Cereus

Author

Savini, Vincenzo, Savini, Vincenzo, Savini, Vincenzo, and Savini, Vincenzo

Abstract

The Diverse Faces of Bacillus cereus elucidates all characteristics of this microorganism, from its environmental and ecologic relevance, to its veterinary involvement, its clinical settings, most common B. cereus associated food poisoning episodes, and the newest airway disease pictures mimicking the inhalation of anthrax. Due to its environmental distribution, B. cereus may cause serious, even fatal human diseases. The organism shows many diverse faces, as it is not only a veterinary pathogen, but also used as a biocontrol agent to control vegetable decay due to its natural antimicrobial properties. Once considered as a mere colonizer or contaminant, Bacillus cereus is nowadays acquiring increasing importance as an agent of nosocomial infections. The book's target audience is familiar with this opportunistic pathogen and will benefit from this clear compendium on the classical and molecular techniques and procedures that may be adopted or followed to correctly identify this intriguing multi-faceted microorganism. Presents an update on the current aspects of Bacillus CereusElucidates all aspects of and provides a concise compendium on the recent literature of Bacillus CereusGives an overview of the patents proposing its use as a natural pesticide

Published
2016

57. Multidrug-resistant infections in long-term care facilities: extended-spectrum β-lactamase–producing Enterobacteriaceae and hypervirulent antibiotic resistant Clostridium difficile

Author

Giufrè, Maria, primary, Accogli, Marisa, additional, Ricchizzi, Enrico, additional, Barbanti, Fabrizio, additional, Farina, Claudio, additional, Fazii, Paolo, additional, Mattei, Romano, additional, Sarti, Mario, additional, Barozzi, Agostino, additional, Buttazzi, Rossella, additional, Cosentino, Marina, additional, Nardone, Maria, additional, Savini, Vincenzo, additional, Spigaglia, Patrizia, additional, Moro, Maria Luisa, additional, and Cerquetti, Marina, additional

Published
2018
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58. Lavandula x intermedia and Lavandula angustifolia essential oils: phytochemical composition and antimicrobial activity against foodborne pathogens

Author

Tardugno, Roberta, primary, Serio, Annalisa, additional, Pellati, Federica, additional, D’Amato, Serena, additional, Chaves López, Clemencia, additional, Bellardi, Maria Grazia, additional, Di Vito, Maura, additional, Savini, Vincenzo, additional, Paparella, Antonello, additional, and Benvenuti, Stefania, additional

Published
2018
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59. Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis

Author

Pompilio, Arianna, primary, Crocetta, Valentina, additional, Savini, Vincenzo, additional, Petrelli, Dezemona, additional, Di Nicola, Marta, additional, Bucco, Silvia, additional, Amoroso, Luigi, additional, Bonomini, Mario, additional, and Di Bonaventura, Giovanni, additional

Published
2018
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67. A case report of the eradication of pseudomonas aeruginosa from leg ulcer in a patient with essential thrombocythemia

Author

Savini, Vincenzo, Catavitello, Chiara, Bianco, Azaira, Balbinot, Andrea, and D'Antonio, Domenico

Subjects
Pseudomonas aeruginosa infections -- Control, Hydroxyurea -- Usage, Hydroxyurea -- Health aspects, Thrombocythemia -- Case studies, Thrombocythemia -- Care and treatment, Thrombocytosis -- Case studies, Thrombocytosis -- Care and treatment, Leg -- Ulcers, Leg -- Drug therapy, Leg -- Case studies, Health
Published
2009

69. Lavandula x intermedia and Lavandula angustifolia essential oils: phytochemical composition and antimicrobial activity against foodborne pathogens.

Author

Tardugno, Roberta, Serio, Annalisa, Pellati, Federica, D'Amato, Serena, Chaves López, Clemencia, Bellardi, Maria Grazia, Di Vito, Maura, Savini, Vincenzo, Paparella, Antonello, and Benvenuti, Stefania

Subjects
ESSENTIAL oils, FOOD pathogens, LAVENDERS, DECONTAMINATION of food, SALMONELLA enterica, LISTERIA monocytogenes
Abstract

Four cultivars (cv) of Lavandula x intermedia ('Abrialis', 'Alba', 'Rinaldi Ceroni' (R.C.) and 'Sumiens') were cultivated in Italy and their essential oils (EOs) were distilled from Alfalfa Mosaic Virus-free plants. These EOs and one from L. angustifolia Miller were chemically characterised by GC-MS and GC-FID. Antimicrobial activity was evaluated against Listeria monocytogenes (24 strains) and Salmonella enterica (10 food strains). Minimal inhibitory concentrations (MIC) ≥ 10.0 μL/mL inhibited Salmonella (cv 'R.C.' was the most active); MIC of 0.3 μL/mL for cv 'Abrialis' and 'R.C.' inhibited L. monocytogenes, revealing noticeable activity, especially on clinical strains. This activity appears related to EOs composition. Particularly cv 'Abrialis' and 'R.C.' showing the highest antimicrobial activity, were rich in the specific constituents: linalool (38.17 and 61.98%), camphor (8.97 and 10.30%), 1,8-cineole (6.89 and 8.11%, respectively). These EOs could find potential applications in food biopreservation and in surface decontamination, even in hospitals, and deserve deeper investigations. [ABSTRACT FROM AUTHOR]

Published
2019
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70. Liofilchem® O.A. Listeria agar and direct CAMP test provided sooner Listeria monocytogenes identification from neonatal bacteremia

Author

Savini, Vincenzo, Marrollo, Roberta, Serio, Annalisa, Paparella, Antonello, Argentieri, Angela Valentina, D'Antonio, Marianna, Coclite, Eleonora, Fusilli, Paola, and Fazii, Paolo

Subjects
Bacteriological Techniques, Histology, Time Factors, Medicine (all), Infant, Newborn, Bacteremia, Newborn, Brief Communication, CAMP test, Listeria monocytogenes, Agar, Neonate, Early Diagnosis, Chromogenic Compounds, Pregnancy, 2734, Humans, Listeriosis
Abstract

Listeria monocytogenes infection in pregnant women and newborns is a cause for serious concern, and invasive disease outcome strongly depends on prompt antibiotic therapy. To provide sooner identification from neonatal bacteremia we performed a CAMP test directly on positive blood aliquots and inoculated the Liofilchem(®) O.A. Listeria chromogenic agar as well, thus providing a 24-h turn-around time for response.

Published
2014

71. Multidrug-Resistant Enterococcus raffinosus From A Decubitus Ulcer: A Case Report

Author

Savini, Vincenzo, Manna, Assunta, Di Bonaventura, Giovanni, Catavitello, Chiara, Talia, Marzia, Balbinot, Andrea, Febbo, Fabio, and D'Antonio, Domenico

Subjects
Enterococcal infections -- Risk factors -- Care and treatment -- Research -- Case studies -- Diagnosis -- Health aspects, Bedsores -- Risk factors -- Diagnosis -- Case studies -- Care and treatment -- Research -- Health aspects, Enterococcus -- Health aspects -- Research -- Case studies, Health, Diagnosis, Care and treatment, Research, Case studies, Risk factors, Health aspects
Abstract

Keywords: Enterococcus raffinosus; decubitus ulcer; daptomycin 36 Case ReportMultidrug-Resistant Enterococcus raffinosus From A Decubitus Ulcer: A Case Report SAGE Publications, Inc.200810.1177/1534734607313757 VincenzoSavini MD Unita Operativa Complessa di Microbiologia e Virologia [...]

Published
2008
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72. Brief tale of a bacteraemia by Rhodococcus equi with concomitant lung mass: what came first, the chicken or the egg?

Author

Savini, Vincenzo, Salutari, Prassede, Sborgia, Marco, Mancini, Iole, Masciarelli, Gioviana, Catavitello, Chiara, Astolfi, Daniela, D’Amario, Claudio, Fioritoni, Giuseppe, Spadaro, Antonio, and D’Antonio, Domenico

Subjects
medicine.medical_specialty, Hematology, Lung, biology, lcsh:RC633-647.5, Case Report, lcsh:Diseases of the blood and blood-forming organs, medicine.disease, biology.organism_classification, Bacterial Infection , Leukemia, Pulmunary Infiltration, Phenotype, Lymphoma, Leukemia, Infectious Diseases, medicine.anatomical_structure, Internal medicine, Concomitant, Immunology, medicine, Rhodococcus equi, Pathogen
Abstract

Rhodococcus equi is an uncommon Gram positive, variably acid-fast agent of infections, that appear as hard to treat mostly owing to the establishment of intracellular niches. Also, the lack of criteria to interpret susceptibility testing may lead to under-reporting or overestimation of resistance expression. Finally, the knowledge about this pathogen’s clinical impact may be affected by wrong characterization at a genus and species level provided by phenotype-based assays.We present the case of a bacteraemia with a concomitant lung mass in a lymphoma patient, that further highlights the emergence of rhodococcal diseases as a matter for concern in the field of infectious diseases and haematology.

Published
2011

76. New Insight into Genotypic and Phenotypic Relatedness of Staphylococcus aureusStrains from Human Infections or Animal Reservoirs

Author

LISOWSKA-ŁYSIAK, KLAUDIA, KOSECKA-STROJEK, MAJA, BIAŁECKA, JOANNA, KASPROWICZ, ANDRZEJ, GARBACZ, KATARZYNA, PIECHOWICZ, LIDIA, KMET, VLADIMIR, SAVINI, VINCENZO, and MIĘDZOBRODZKI, JACEK

Abstract

Staphylococcus aureusis a common human and livestock opportunistic pathogen, and there is evidence of animal to human transmission. This paper aimed to recognize properties of the isolates from collections of human and livestock S. aureusstrains and to estimate compatibility of results based on phenotypic tests, microarrays and the spatyping methods. The second goal was to study differences between human and animal isolates in terms of specificity of their hosts and the strain transmission among various hosts. Most strains showed multi-susceptible profiles and produced enzymes on a high level, and they were phenotypically and genetically similar. However, in contrast to the Polish bovine mastitis strains, the Slovakian strains were multi-resistant. In this research, the strains showed significant differences in terms of their phenotypic manifestations and the presence of hemolysins genes; however, other enzyme-encoding genes correlated to a higher extent with the microarrays results. Interestingly, there was a lack of enterotoxin genes in human Poultry-like protein A+ strains in comparison to other human strains. Our study showed that differences between virulence profiles of the human and animal strains correlated with their origin rather than their hosts, and any trait allowed clearly distinguishing between them based on the microarray results.

Published
2019
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82. Coagulase-positive staphylococci: my pet's two faces

Author

Savini, Vincenzo, primary, Passeri, Cecilia, additional, Mancini, Giorgia, additional, Iuliani, Ornella, additional, Marrollo, Roberta, additional, Argentieri, Angela Valentina, additional, Fazii, Paolo, additional, D'Antonio, Domenico, additional, and Carretto, Edoardo, additional

Published
2013
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83. An atypical, pigment-producingMetschnikowiastrain from a leukaemia patient

Author

Savini, Vincenzo, primary, Hendrickx, Marijke, additional, Sisti, Maurizio, additional, Masciarelli, Gioviana, additional, Favaro, Marco, additional, Fontana, Carla, additional, Pitzurra, Lucia, additional, Arzeni, Daniela, additional, Astolfi, Daniela, additional, Catavitello, Chiara, additional, Polilli, Ennio, additional, Farina, Claudio, additional, Fazii, Paolo, additional, D’antonio, Domenico, additional, and Stubbe, Dirk, additional

Published
2013
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84. Methicillin-Resistant Staphylococcus pseudintermedius Infection in a Bone Marrow Transplant Recipient

Author

Savini, Vincenzo, primary, Barbarini, Daniela, additional, Polakowska, Klaudia, additional, Gherardi, Giovanni, additional, Białecka, Anna, additional, Kasprowicz, Andrzej, additional, Polilli, Ennio, additional, Marrollo, Roberta, additional, Di Bonaventura, Giovanni, additional, Fazii, Paolo, additional, D'Antonio, Domenico, additional, Międzobrodzki, Jacek, additional, and Carretto, Edoardo, additional

Published
2013
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85. Looking for nonhemolytic group B streptococci

Author

Savini, Vincenzo, primary, Santarelli, Alessandro, additional, Polilli, Ennio, additional, D’Antonio, Marianna, additional, Astolfi, Daniela, additional, Marrollo, Roberta, additional, Fazii, Paolo, additional, and D’Antonio, Domenico, additional

Published
2013
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86. Hafnia alvei from the farm to the delivery room

Author

Savini, Vincenzo, primary, Santarelli, Alessandro, additional, Polilli, Ennio, additional, Astolfi, Daniela, additional, Pompilio, Arianna, additional, Di Bonaventura, Giovanni, additional, Fazii, Paolo, additional, and D’Antonio, Domenico, additional

Published
2013
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91. About the Bacillus cereus Group

Author

Savini, Vincenzo, primary, Polilli, Ennio, additional, Marrollo, Roberta, additional, Astolfi, Daniela, additional, Fazii, Paolo, additional, and D'Antonio, Domenico, additional

Published
2013
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93. Preliminary Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women with Primary Cytomegalovirus Infection

Author

Polilli, Ennio, primary, Parruti, Giustino, additional, D'Arcangelo, Francesca, additional, Tracanna, Elisa, additional, Clerico, Luigi, additional, Savini, Vincenzo, additional, D'Antonio, Francesco, additional, Rosati, Maurizio, additional, Manzoli, Lamberto, additional, D'Antonio, Domenico, additional, and Nigro, Giovanni, additional

Published
2012
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96. Phenotypic and genotypic characterization of Stenotrophomonas maltophiliaisolates from patients with cystic fibrosis: Genome diversity, biofilm formation, and virulence

Author

Pompilio, Arianna, primary, Pomponio, Stefano, additional, Crocetta, Valentina, additional, Gherardi, Giovanni, additional, Verginelli, Fabio, additional, Fiscarelli, Ersilia, additional, Dicuonzo, Giordano, additional, Savini, Vincenzo, additional, D'Antonio, Domenico, additional, and Di Bonaventura, Giovanni, additional

Published
2011
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98. Multidrug-resistant Geotrichum capitatum from a haematology ward

Author

Savini, Vincenzo, primary, Catavitello, Chiara, additional, Balbinot, Andrea, additional, Masciarelli, Gioviana, additional, Astolfi, Daniela, additional, Pompilio, Arianna, additional, Di Bonaventura, Giovanni, additional, D’Amario, Claudio, additional, and D’Antonio, Domenico, additional

Published
2010
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99. Adhesion to and biofilm formation on IB3-1 bronchial cells by Stenotrophomonas maltophilia isolates from cystic fibrosis patients

Author

Pompilio, Arianna, primary, Crocetta, Valentina, additional, Confalone, Pamela, additional, Nicoletti, Mauro, additional, Petrucca, Andrea, additional, Guarnieri, Simone, additional, Fiscarelli, Ersilia, additional, Savini, Vincenzo, additional, Piccolomini, Raffaele, additional, and Di Bonaventura, Giovanni, additional

Published
2010
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