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51. Reliability and validity of a screen time-based sedentary behaviour questionnaire for adolescents: The HELENA study

Author: Rey López, Juan P., Ruiz, Jonatan R., Ortega, Francisco B., Verloigne, Maite, Vicente Rodriguez, German, Gracia Marco, Luis, Gottrand, Frederic, Molnar, Denes, Widhalm, Kurt, Zaccaria, Maria, Cuenca García, Magdalena, Sjöström, Michael, De Bourdeaudhuij, Ilse, Moreno, Luis A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Gracia Marco L, Mouratidou T, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöström M, Ruiz J, Hagströmer M, Hallström L, Patterson E, Kwak L, Rizzo N, Hurtig Wennlöf A, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Rey López, Juan P., Ruiz, Jonatan R., Ortega, Francisco B., Verloigne, Maite, Vicente Rodriguez, German, Gracia Marco, Lui, Gottrand, Frederic, Molnar, Dene, Widhalm, Kurt, Zaccaria, Maria, Cuenca García, Magdalena, Sjöström, Michael, De Bourdeaudhuij, Ilse, Moreno, Luis A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Gracia Marco, L, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöström, M, Ruiz, J, Hagströmer, M, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Hurtig Wennlöf, A, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Gerontology, Male, medicine.medical_specialty, Validation study, Television viewing, Time Factors, Time Factor, Adolescent, Health Behavior, Reproducibility of Result, Screen time, Computer, Reliability study, Surveys and Questionnaires, Epidemiology, medicine, Surveys and Questionnaire, Humans, Exercise, Life Style, Reliability (statistics), Sedentary time, Internet, Computers, Public Health, Environmental and Occupational Health, Reproducibility of Results, Health Survey, Health Surveys, Physical therapy, Female, Television, Health behavior, Psychology, Human
Abstract: Background: Although there is a growing interest in the epidemiology of sedentary behaviours, it is unknown whether sedentary behaviour questionnaires are broad markers of sedentary time. The aims of this study were to determine the: (i) reliability of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) screen time-based sedentary behaviour questionnaire; and (ii) its validity, i.e. the ability of the questionnaire to correctly rank adolescents according to the objectively measured sedentary time. Methods: A total of 183 adolescents (104 females aged 12.5–17.5 years) were involved in the reliability study. Participants completed the HELENA sedentary questionnaire twice (1 week apart). The validity study comprised 2048 (1212 females) adolescents (12.5–17.5 years of age) included in the HELENA cross-sectional study. Questions included television viewing, computer games, console games, Internet for study and non-study reasons and study during week and weekend days. We compared median values of sedentary time, using accelerometers, by tertiles of self-reported sedentary behaviours and their sum (composite sedentary score). Results: Reliability study: κ-values showed a good agreement (>0.7), except for Internet for study reasons (0.46 weekdays, 0.33 weekend). The questionnaire correctly classified boys’ sedentary time when analysed by specific behaviours and by a composite sedentary score. In girls, median values of objectively measured sedentary time were not different across tertiles of self-reported sedentary behaviours or the composite sedentary score. Conclusion: The HELENA sedentary questionnaire is reliable, yet only correctly classifies objectively measured sedentary time in boys.
Published: 2011

52. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study

Author: Labayen, Idoia, Moreno, Luis A., Ruiz, Jonatan R., Ortega, Francisco B., Sjostrom, Michael, Huybrechts, Inge, Gonzalez Gross, Marcela, Spinneker, André, De Henauw, Stefaan, Manios, Yannis, Molnar, Dénés, Leclercq, Catherine, Gottrand, Frédéric, Moreno LA, Gottrand F, González Gross M, Gilbert C, Kafatos A, Libersa C, De Henauw S, Castelló S, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Mouratidou T, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz LE, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Wennlöf AH, Hallström L, Patterson E, Kwak L, Rizzo N, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtue J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Labayen, Idoia, Moreno, Luis A., Ruiz, Jonatan R., Ortega, Francisco B., Sjostrom, Michael, Huybrechts, Inge, Gonzalez Gross, Marcela, Spinneker, André, De Henauw, Stefaan, Manios, Yanni, Molnar, Déné, Leclercq, Catherine, Gottrand, Frédéric, Moreno, La, Gottrand, F, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, De Henauw, S, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, Le, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Wennlöf, Ah, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtue, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Male, Long chain polyunsaturated fatty acid, medicine.medical_specialty, Adolescent, Docosahexaenoic Acids, Nutritional Sciences, Birth weight, Linoleic acid, Biology, Body Mass Index, Linoleic Acid, Nutritional Science, chemistry.chemical_compound, Internal medicine, medicine, Birth Weight, Humans, Life Style, Cross-Sectional Studie, Docosahexaenoic Acid, chemistry.chemical_classification, Arachidonic Acid, alpha-Linolenic Acid, medicine.disease, Eicosapentaenoic acid, Diet, Europe, Phospholipid, Endocrinology, Cross-Sectional Studies, chemistry, Eicosapentaenoic Acid, Docosahexaenoic acid, Fatty Acids, Unsaturated, HELENA study, lipids (amino acids, peptides, and proteins), Arachidonic acid, Female, Metabolic syndrome, Cardiology and Cardiovascular Medicine, Body mass index, Human, Polyunsaturated fatty acid
Abstract: Nutritional factors in early life may have long-term physiologic effects in humans. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play important roles in protecting against cardiovascular disease (CVD) risk. Our aim was to examine the association of birth weight (BW) with serum long chain polyunsaturated fatty acids (LCPUFA) profile in adolescents.A total of 772 European adolescents (56.3% females) aged 14.7 ± 1.2 years were included in this study. Information on BW and gestational age was obtained from parental records. DHA, EPA and arachidonic acid (AA) concentrations were measured in serum phospholipids. Alfa-linolenic (ALA), linoleic (LA), AA, EPA and DHA intakes assessed by a computer based 24h dietary recall. Gender, gestational age, pubertal status, body mass index, center and total energy and LCPUFA intakes were used as confounders in all the analyses.BW was significantly associated with serum DHA and EPA (both adjusted P0.05) independently of potential confounders including their main dietetic source. We did not observe any significant relationship between BW and serum AA levels.Our findings suggest that early metabolic changes, as a result from prenatal environmental influences, could affect long chain polyunsaturated fatty acid metabolism later in life. These results may contribute to explain the relationship between early nutrition and growth and later metabolic disorders as CVD.
Published: 2011

53. Excessive sedentary time and low cardiorespiratory fitness in European adolescents: the HELENA study

Author: Martinez Gomez, David, Ortega, Francisco B., Ruiz, Jonatan R., Vicente Rodriguez, Germán, Veiga, Oscar L., Widhalm, Kurt, Manios, Yannis, Béghin, Laurent, Valtueña, Jara, Kafatos, Anthony, Molnar, Denes, Moreno, Luis A., Marcos, Ascension, Castillo, Manuel J., Sjöström, Michael, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Martinez Gomez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz Ruiz J, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Martinez Gomez, David, Ortega, Francisco B., Ruiz, Jonatan R., Vicente Rodriguez, Germán, Veiga, Oscar L., Widhalm, Kurt, Manios, Yanni, Béghin, Laurent, Valtueña, Jara, Kafatos, Anthony, Molnar, Dene, Moreno, Luis A., Marcos, Ascension, Castillo, Manuel J., Sjöström, Michael, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Martinez Gomez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz Ruiz, J, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Male, medicine.medical_specialty, Adolescent, Physical fitness, Physical activity, Motor Activity, Body Mass Index, Leisure Activities, Medicine, Humans, Child, Cross-Sectional Studie, Sedentary time, Sex Characteristics, Anthropometry, business.industry, Cardiorespiratory fitness, Sex Characteristic, Cross-Sectional Studies, Physical Fitness, Sedentary Lifestyle, Leisure Activitie, Pediatrics, Perinatology and Child Health, Physical Fitne, Physical therapy, Exercise Test, Female, Sedentary Behavior, business, Human
Abstract: Background: The aims of this study were to examine what amount of s edentary time is associated with low cardiorespiratory fitness (CRF) in adolescents and whether this association is independent of physical activity. Methods: The study comprised 1808 adolescents aged 12.5-17.5 years from 10 European cities. Sedentary time and moderate-to-vigorous physical activity (MVPA) were measured by accelerometer. CRF was assessed by the 20 m shuttle-run test. Adolescents were divided into two groups (high/low) according to FITNESSGRAM guidelines. Receiver-operating characteristic (ROC) analysis was used to determine thresholds that best discriminate between high and low CRF in adolescents. Results: Adolescent girls had more sedentary time than boys (p0.05) in those who met the recommendation (≥60 min/day in MVPA). Conclusion: Excessive sedentary time is associated with low CRF in adolescent girls but not in boys. However, this adverse effect might be attenuated if adolescent girls meet the current physical activity guidelines.
Published: 2011

54. Relationship between self-reported dietary intake and physical activity levels among adolescents: The HELENA study

Author: Ottevaere, Charlene, Huybrechts, Inge, Béghin, Laurent, Cuenca Garcia, Magdalena, De Bourdeaudhuij, Ilse, Gottrand, Frederic, Hagströmer, Maria, Kafatos, Anthony, Le Donne, Cinzia, Moreno, Luis A., Sjöström, Michael, Widhalm, Kurt, De Henauw, Stefaan, Moreno L, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús J, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Ma Garagorri J, Bueno M, Pablo Rey López J, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz JR, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Fievet N, Goumidi L, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Hurtig Wennlöf A, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, José Sánchez M, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, José Gómez Lorente J., VITAGLIONE, PAOLA, Department of Public Health, Universiteit Gent = Ghent University [Belgium] (UGENT), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Réseau Maladies Inflammatoires Chroniques de l'Intestin (RMICI), CIC 9301 CH&U et Inserm-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Physiology, School of Medicine, Department of Movement and Sport Sciences, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], University of Crete School of medicine, National Research Institute on Food and Nutrition, Growth, Exercise, Nutrition and Development (GENUD), University of Zaragoza - Universidad de Zaragoza [Zaragoza]-E.U. Ciencias de la Salud, Medizinische Universität Wien = Medical University of Vienna, The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM)., Matthys, Christophe, Ottevaere, Charlene, Huybrechts, Inge, Béghin, Laurent, Cuenca Garcia, Magdalena, De Bourdeaudhuij, Ilse, Gottrand, Frederic, Hagströmer, Maria, Kafatos, Anthony, Le Donne, Cinzia, Moreno, Luis A., Sjöström, Michael, Widhalm, Kurt, De Henauw, Stefaan, Moreno, L, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, J, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Ma Garagorri, J, Bueno, M, Pablo Rey López, J, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz, Jr, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Fievet, N, Goumidi, L, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Hurtig Wennlöf, A, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, José Sánchez, M, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, José Gómez Lorente, J., BMC, Ed., Universiteit Gent = Ghent University (UGENT), and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
Subjects: Male, Physiology, 030309 nutrition & dietetics, Health Behavior, CHILDHOOD, Medicine (miscellaneous), ACTIVITY QUESTIONNAIRE, CHILDREN, ADULTHOOD, Overweight, Motor activity, Food group, 0302 clinical medicine, Nutrient, Medicine and Health Sciences, Nutrition and Dietetic, lcsh:RC620-627, EUROPEAN ADOLESCENTS, 2. Zero hunger, Sex Characteristics, 0303 health sciences, Nutrition and Dietetics, Medicine (all), lcsh:Public aspects of medicine, Health Survey, 3. Good health, Europe, lcsh:Nutritional diseases. Deficiency diseases, Health, Cross-sectional studies, Female, FOOD-HABITS, medicine.symptom, Life Sciences & Biomedicine, Human, Sex characteristics, Adolescent, Food habits, 030209 endocrinology & metabolism, Physical Therapy, Sports Therapy and Rehabilitation, Clinical nutrition, Motor Activity, BEHAVIORS, 03 medical and health sciences, Environmental health, medicine, Humans, Dairy Product, Life Style, Cross-Sectional Studie, Science & Technology, OVERWEIGHT, Nutrition & Dietetics, business.industry, Research, lcsh:RA1-1270, HEALTHY LIFE-STYLE, Feeding Behavior, Sex Characteristic, medicine.disease, Health Surveys, Obesity, Physical activity level, Diet, BODY-MASS INDEX, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Cross-Sectional Studies, Adolescent Behavior, Fruit, Food Habit, Life style, Energy intake, Dairy Products, Self Report, Energy Intake, business, Body mass index, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Background Evidence suggests possible synergetic effects of multiple lifestyle behaviors on health risks like obesity and other health outcomes. Therefore it is important to investigate associations between dietary and physical activity behavior, the two most important lifestyle behaviors influencing our energy balance and body composition. The objective of the present study is to describe the relationship between energy, nutrient and food intake and the physical activity level among a large group of European adolescents. Methods The study comprised a total of 2176 adolescents (46.2% male) from ten European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. Dietary intake and physical activity were assessed using validated 24-h dietary recalls and self-reported questionnaires respectively. Analyses of covariance (ANCOVA) were used to compare the energy and nutrient intake and the food consumption between groups of adolescents with different physical activity levels (1st to 3rd tertile). Results In both sexes no differences were found in energy intake between the levels of physical activity. The most active males showed a higher intake of polysaccharides, protein, water and vitamin C and a lower intake of saccharides compared to less active males. Females with the highest physical activity level consumed more polysaccharides compared to their least active peers. Male and female adolescents with the highest physical activity levels, consumed more fruit and milk products and less cheese compared to the least active adolescents. The most active males showed higher intakes of vegetables and meat, fish, eggs, meat substitutes and vegetarian products compared to the least active ones. The least active males reported the highest consumption of grain products and potatoes. Within the female group, significantly lower intakes of bread and cereal products and spreads were found for those reporting to spend most time in moderate to vigorous physical activity. The consumption of foods from the remaining food groups, did not differ between the physical activity levels in both sexes. Conclusion It can be concluded that dietary habits diverge between adolescents with different self-reported physical activity levels. For some food groups a difference in intake could be found, which were reflected in differences in some nutrient intakes. It can also be concluded that physically active adolescents are not always inclined to eat healthier diets than their less active peers., The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM).
Published: 2011
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55. Evaluation of iron status in European adolescents through biochemical iron indicators : the HELENA Study

Author: Ferrari, M, Mistura, L., Patterson, E., Sjöström, M., Díaz, L. E., Stehle, P., Gonzalez Gross, M., Kersting, M., Widhalm, K., Molnár, D., Gottrand, F., De Henauw, S., Manios, Y., Kafatos, A., Moreno, L. A., Leclercq, C., Luis A. Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Moreno LA, Libersa C, Sáchez J, Kesting M, Sjostrom M, Molnár D, Gonzállez Gross M, Dallongeville J, Hall G, Maes L, Scalfi L, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano M, Zapatera B, Pozo T, Béghin L, Christian Libersa C, Catalina Iliescu C, Von Berlepsch J, Kersting MK, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavon D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Wārnberg J, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel BV, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez M, Castello S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Ferrari, M, Mistura, L., Patterson, E., Sjöström, M., Díaz, L. E., Stehle, P., Gonzalez Gross, M., Kersting, M., Widhalm, K., Molnár, D., Gottrand, F., De Henauw, S., Manios, Y., Kafatos, A., Moreno, L. A., Leclercq, C., Luis A., Moreno LA, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Moreno, La, Libersa, C, Sáchez, J, Kesting, M, Sjostrom, M, Molnár, D, Gonzállez Gross, M, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, M, Zapatera, B, Pozo, T, Béghin, L, Christian Libersa, C, Catalina Iliescu, C, Von Berlepsch, J, Kersting, Mk, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavon, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Wārnberg, J, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, Bv, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, M, Castello, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, Lorente, J. J., Applied Food Science, and Matthys, Christophe
Subjects: Male, 030309 nutrition & dietetics, Medicine (miscellaneous), CHILDREN, Sex Factor, RETINOL, 0302 clinical medicine, iron deficiency, Sex factors, Prevalence, Medicine and Health Sciences, adolescents, 030212 general & internal medicine, 10. No inequality, 0303 health sciences, Nutrition and Dietetics, Anemia, Iron-Deficiency, Nutritional status, Iron Deficiencies, Iron blood, 3. Good health, DEFICIENCY, Europe, Nutritional Statu, Original Article, Female, NUTRITION, Iron status, FERRITIN, Human, medicine.medical_specialty, Adolescent, European community, QUALITY-ASSURANCE, Adolescent Nutritional Physiological Phenomena, Iron, Nutritional Status, 03 medical and health sciences, Sex Factors, Environmental health, medicine, Humans, ANEMIA, Cross-Sectional Studie, Ferritin, Blood Chemical Analysis, anaemia, business.industry, Blood Chemical Analysi, Biomarker, Surgery, Cross-Sectional Studies, Multicenter study, adolescent, Ferritins, SOLUBLE TRANSFERRIN RECEPTOR, business, Biomarkers
Abstract: Background/Objectives: To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities. Subjects/Methods: Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF8.5 mg/l) plus iron depletion. Iron deficiency anaemia (IDA) was defined as ID with haemoglobin (Hb) below the WHO cutoff for age and sex: 12.0 g/dl for girls and for boys aged 12.5–14.99 years and 13.0 g/dl for boys aged greater than or equal to15 years. Enzyme linked immunosorbent assay was used as analytical method for SF, sTfR and C-reactive protein (CRP). Subjects with indication of inflammation (CRP >5 mg/l) were excluded from the analyses. A total of 940 adolescents aged 12.5–17.49 years (438 boys and 502 girls) were involved. Results: The percentage of iron depletion was 17.6%, significantly higher in girls (21.0%) compared with boys (13.8%). The overall percentage of ID and IDA was 4.7 and 1.3%, respectively, with no significant differences between boys and girls. A correlation was observed between log (SF) and Hb (r=0.36, P, The HELENA Study was supported financially by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034).
Published: 2011
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56. Objectively measured physical activity and sedentary time in european adolescents

Author: Ruiz, Jonatan R., Ortega, Francisco B., Martínez Gómez, David, Labayen, Idoia, Moreno, Luis A., De Bourdeaudhuij, Ilse, Manios, Yannis, Gonzalez Gross, Marcela, Mauro, Beatrice, Molnar, Denes, Widhalm, Kurt, Marcos, Ascensión, Beghin, Laurent, Castillo, Manuel J., Sjöström, Michael, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrí L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Boriss Riedl BK, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Ruiz, Jonatan R., Ortega, Francisco B., Martínez Gómez, David, Labayen, Idoia, Moreno, Luis A., De Bourdeaudhuij, Ilse, Manios, Yanni, Gonzalez Gross, Marcela, Mauro, Beatrice, Molnar, Dene, Widhalm, Kurt, Marcos, Ascensión, Beghin, Laurent, Castillo, Manuel J., Sjöström, Michael, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrí, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Boriss Riedl, Bk, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.
Subjects: Europe, Cross-Sectional Studie, Male, obesity, physical fitne, sedentary lifestyle, exercise, Adolescent, motor activity, Epidemiology, Female, social cla, Human
Published: 2011

57. Fitness and fatness are independently associated with markers of insulin resistance in European adolescents; The HELENA Study

Author: Jiménez Pavón, David, Castillo, Manuel J., Moreno, Luis A., Kafatos, Anthony, Manios, Yannis, Kondaki, Katerine, Béghin, Laurent, Zaccaria, Maria, De Henauw, Stefaan, Widhalm, Kurt, Molnár, Dénes, Sjöström, Michael, González Gross, Marcela, Ruiz, Jonatan R., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Ma Garagorri J, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz Ruiz J, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, José Sánchez M, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Jiménez Pavón, David, Castillo, Manuel J., Moreno, Luis A., Kafatos, Anthony, Manios, Yanni, Kondaki, Katerine, Béghin, Laurent, Zaccaria, Maria, De Henauw, Stefaan, Widhalm, Kurt, Molnár, Déne, Sjöström, Michael, González Gross, Marcela, Ruiz, Jonatan R., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Ma Garagorri, J, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz Ruiz, J, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, José Sánchez, M, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Blood Glucose, Male, Cross-sectional study, medicine.medical_treatment, Body Mass Index, Insulin, Age Factor, Skinfold Thickne, Adiposity, Nutrition and Dietetics, Health Policy, Age Factors, Health Survey, Europe, Skinfold Thickness, Cardiorespiratory fitne, Regression Analysis, Female, Waist Circumference, Human, medicine.medical_specialty, Waist, Adolescent, Regression Analysi, Insulin resistance, Internal medicine, medicine, HOMA, Humans, Obesity, Cardiovascular fitness, Cross-Sectional Studie, Analysis of Variance, business.industry, Body Weight, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, Cardiorespiratory fitness, medicine.disease, Health Surveys, Body Height, Total and central body fat, Endocrinology, Cross-Sectional Studies, Glucose, Physical Fitness, Pediatrics, Perinatology and Child Health, Exercise Test, Physical Fitne, Insulin Resistance, business, Body mass index
Abstract: To examine the independent association of total and central body fat and cardiorespiratory fitness with markers of insulin resistance after controlling for several potential confounders in European adolescents participating in the HELENA-CSS (Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional) study.We conducted a cross sectional study (the HELENA-CSS) which comprised 1053 (12.5-17.5 years) adolescents from 10 European cities. Weight, height, waist circumference and skinfold thickness were measured, and body mass index (BMI) was calculated. Cardiorespiratory fitness was measured by the 20-m shuttle run test. Markers of insulin resistance were fasting insulin and glucose, and homeostasis model assessment (HOMA).HOMA and insulin were positively associated with BMI, skinfolds and waist circumference after controlling for center, age, pubertal status and cardiorespiratory fitness (all P ? 0.01). HOMA and insulin were negatively associated with cardiorespiratory fitness in adolescents with moderate to high levels of total and central body fat (all P ? 0.01).HOMA and insulin were associated with total and central body fat in European adolescents. Moreover, cardiorespiratory fitness explained a part of the HOMA and insulin variance in those adolescents with moderate to high levels of total and central body fat, and also, to some extent, in those with low to middle fat mass.
Published: 2011

58. Pilot evaluation of the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Food-O-Meter, a computer-tailored nutrition advice for adolescents: a study in six European cities

Author: Maes, Lea, Cook, Tina Louisa, Ottovaere, Charlene, Matthijs, Christophe, Moreno, Luis A., Kersting, Mathilde, Papadaki, Alina, Manios, Yannis, Dietrich, Sabine, Hallström, Lena, Haerens, Leen, De Bourdeaudhuij, Ilse, Vereecken, Carine, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz Ruiz J, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Maes, Lea, Cook, Tina Louisa, Ottovaere, Charlene, Matthijs, Christophe, Moreno, Luis A., Kersting, Mathilde, Papadaki, Alina, Manios, Yanni, Dietrich, Sabine, Hallström, Lena, Haerens, Leen, De Bourdeaudhuij, Ilse, Vereecken, Carine, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz Ruiz, J, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Program evaluation, Cross-Cultural Comparison, Male, Adolescent, Adolescent Nutritional Physiological Phenomena, Medicine (miscellaneous), Intervention, Pilot Projects, Child Nutrition Sciences, Health Promotion, law.invention, Randomized controlled trial, law, Internet based, Intervention (counseling), Environmental health, Child Nutrition Science, Nutrition and Dietetic, Medicine, Humans, Pilot Project, Advice, Child, Life Style, Dietary Fat, Nutrition, Internet, Nutrition and Dietetics, business.industry, Life style, Public Health, Environmental and Occupational Health, Overweight, Cross-cultural studies, Dietary Fats, Feasibility Studie, Europe, Multicenter study, Adolescent Behavior, Feasibility Studies, The Internet, Female, business, Human, Program Evaluation
Abstract: OBJECTIVE: To investigate the feasibility and impact of the Food-O-Meter, an Internet-based computer-tailored nutrition intervention in adolescents. DESIGN: Participants in the intervention condition received the computer-tailored advice at baseline and at 1 month, those in the control condition received standardised advice. Effects were evaluated at 1 month (n 621) and at 3 months (n 558) using multi-level modelling. SETTING: Secondary schools in six European cities. Adolescents accessed the intervention in the school computer room under the supervision of teachers. SUBJECTS: Classes with students aged 12-17 years in the schools participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) cross-sectional study were randomised into intervention and control schools. RESULTS: In most participating centres the intervention was feasible and generally well appreciated, especially by girls. Technical problems and lack of motivation of the teachers hindered implementation in some centres. Overweight adolescents had higher scores for reading and using the advice than normal weight adolescents. After 1 month adolescents receiving the standardised advice reported an increase in fat intake, while fat intake in the intervention condition was stable (F = 4·82, P < 0·05). After 3 months, there was a trend in the total group for an intervention effect of the tailored advice on fat intake (F = 2·80, P < 0·10). In the overweight group there was a clear positive effect (F = 5·76, P < 0·05). CONCLUSIONS: The Food-O-Meter should be developed further. The results were modest but clear for percentage energy from fat, specifically in the overweight group. Adaptations based on new research are needed to enhance the reliability and effectiveness of the intervention.
Published: 2011

59. Levels of physical activity that predict optimal bone mass in adolescents: The HELENA study

Author: Gracia Marco, Luis, Moreno, Luis A., Ortega, Francisco B., Len, Francisco, Sioen, Isabelle, Kafatos, Anthony, Martinez Gomez, David, Widhalm, Kurt, Castillo, Manuel J., Vicente Rodrguez, Germn, Moreno LA, Gottrand F, De Henauw S, González Gross M, Kafatos A, Libersa C, Castelló S, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Gilbert C, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Gracia Marco L, Mouratidou T, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz LE, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Wennlöf AH, Hallström L, Patterson E, Kwak L, Rizzo N, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Gracia Marco, Lui, Moreno, Luis A., Ortega, Francisco B., Len, Francisco, Sioen, Isabelle, Kafatos, Anthony, Martinez Gomez, David, Widhalm, Kurt, Castillo, Manuel J., Vicente Rodrguez, Germn, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Kafatos, A, Libersa, C, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Gilbert, C, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Gracia Marco, L, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, Le, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Wennlöf, Ah, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Epidemiology, Public Health, Environmental and Occupational Health
Published: 2011

60. Nutritional knowledge in European adolescents : results from the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study

Author: Sichert Hellert, Wolfgang, Beghin, Laurent, De Henauw, Stefaan, Grammatikaki, Evangelia, Hallström, Lena, Manios, Yannis, Mesana, María I, Molnár, Dénes, Dietrich, Sabine, Piccinelli, Raffaela, Plada, Maria, Sjöström, Michael, Moreno, Luis A, Kersting, Mathilde, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Garzón MJ, Sáinz ÁG, Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz CS, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Sichert Hellert, Wolfgang, Beghin, Laurent, De Henauw, Stefaan, Grammatikaki, Evangelia, Hallström, Lena, Manios, Yanni, Mesana, María I, Molnár, Déne, Dietrich, Sabine, Piccinelli, Raffaela, Plada, Maria, Sjöström, Michael, Moreno, Luis A, Kersting, Mathilde, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, Mj, Sáinz, Ág, Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.
Subjects: Male, Gerontology, Health Knowledge, Attitudes, Practice, Medicin och hälsovetenskap, Cross-sectional study, Medicine (miscellaneous), Sex Factor, Socioeconomic Factor, Medical and Health Sciences, Sex factors, Surveys and Questionnaires, Nutritional knowledge, Nutrition and Dietetic, gender, Surveys and Questionnaire, Cluster Analysis, Medicine, Age Factor, Child, Meals, Adolescent Nutritional Physiological Phenomena, Nutrition and Dietetics, Socio-economic statu, Age Factors, Large sample, Europe, Nutritional Statu, Female, Human, Adolescent, Socio-economic status, Nutritional Status, Sex Factors, Nutrition knowledge, Humans, Meal, Life Style, Socioeconomic status, Cross-Sectional Studie, Cluster Analysi, business.industry, Body Weight, Public Health, Environmental and Occupational Health, Gender, Feeding Behavior, Healthy diet, Cross-Sectional Studies, Socioeconomic Factors, Food Habit, Multiple-choice test, business, Body mass index
Abstract: ObjectiveTo build up sufficient knowledge of a ‘healthy diet’. Here, we report on the assessment of nutritional knowledge using a uniform method in a large sample of adolescents across Europe.DesignA cross-sectional study.SettingThe European multicentre HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study conducted in 2006–2007 in ten cities in Austria, Belgium, France, Germany, Greece (one inland and one island city), Hungary, Italy, Spain and Sweden.SubjectsA total of 3546 adolescents (aged 12·5–17·5 years) completed a validated nutritional knowledge test (NKT). Socio-economic variables and anthropometric data were considered as potential confounders.ResultsNKT scores increased with age and girls had higher scores compared with boys (62 % v. 59 %; P < 0·0001). Scores were approximately 10 % lower in ‘immigrant’ adolescents or in adolescents with ‘immigrant’ mothers. Misconceptions with respect to the sugar content in food or in beverages were found. Overall, there was no correlation between BMI values and NKT scores. After categorization according to BMI, scores increased significantly with BMI group only in boys. These differences disappeared after controlling for socio-economic status (SES). Smoking status and educational level of the mother influenced the NKT scores significantly in boys, as well as the educational levels of both parents in girls.ConclusionsNutritional knowledge was modest in our sample. Interventions should be focused on the lower SES segments of the population. They should be initiated at a younger age and should be combined with environmental prevention (e.g. healthy meals in school canteens).
Published: 2011

61. Longer breastfeeding is associated with increased lower body explosive strength during adolescence

Author: Artero, Enrique G., Ortega, Francisco B., España Romero, Vanesa, Labayen, Idoia, Huybrechts, Inge, Papadaki, Angeliki, Rodriguez, Gerardo, Mauro, Beatrice, Widhalm, Kurt, Kersting, Mathilde, Manios, Yannis, Molnar, Denes, Moreno, Luis A., Sjöström, Michael, Gottrand, Frederic, Castillo, Manuel J., De Henauw, Stefaan, Moreno LA, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri J, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Martinez Gomez D, Beghin L, Libersa C, Gottrand F, Iliescu C, Von Berlepsch J, Kersting M, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Kafatos A, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas Manolis Sbokos C, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, González Gross M, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz Á, Ortega Porcel FB, Ruiz Ruiz J, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Aparicio V, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Scalfi L, Montagnese C, De Bourdeaudhuij I, De Henauw S, De Vriendt T, Maes L, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaisk C, Dallongeville J, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Hurtig Wennlöf A, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Gilbert C, Thomas S, Allchurch E, Burguess P, Hall G, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Artero, Enrique G., Ortega, Francisco B., España Romero, Vanesa, Labayen, Idoia, Huybrechts, Inge, Papadaki, Angeliki, Rodriguez, Gerardo, Mauro, Beatrice, Widhalm, Kurt, Kersting, Mathilde, Manios, Yanni, Molnar, Dene, Moreno, Luis A., Sjöström, Michael, Gottrand, Frederic, Castillo, Manuel J., De Henauw, Stefaan, Moreno, La, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, J, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martinez Gomez, D, Beghin, L, Libersa, C, Gottrand, F, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Kafatos, A, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas Manolis Sbokos, C, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, González Gross, M, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, Á, Ortega Porcel, Fb, Ruiz Ruiz, J, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Aparicio, V, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Scalfi, L, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Henauw, S, De Vriendt, T, Maes, L, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaisk, C, Dallongeville, J, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Hurtig Wennlöf, A, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Gilbert, C, Thomas, S, Allchurch, E, Burguess, P, Hall, G, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Multi-stage fitness test, Male, Pediatrics, medicine.medical_specialty, Aging, Adolescent, Birth weight, Physical fitness, Statistics as Topic, Breastfeeding, Medicine (miscellaneous), Athletic Performance, Physical strength, Surveys and Questionnaires, Nutrition and Dietetic, medicine, Surveys and Questionnaire, Humans, Mass index, Muscle Strength, Child, Infant Nutritional Physiological Phenomena, Cross-Sectional Studie, Nutrition and Dietetics, Anthropometry, business.industry, Medicine (all), Infant, Nutrition Survey, Nutrition Surveys, Europe, Breast Feeding, Cross-Sectional Studies, Lower Extremity, Physical Fitness, Physical Fitne, Female, business, Breast feeding, Human
Abstract: Our aim in this study was to examine the association between breastfeeding duration and cardiorespiratory fitness, isometric strength, and explosive strength during adolescence. A total of 2567 adolescents (1426 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study aged 12.5-17.5 y were included. Information about duration of any and exclusive breastfeeding was obtained retrospectively by means of a parental questionnaire. The 20-m shuttle run, handgrip strength, and standing long jump tests were used to assess physical fitness. Significant differences among the categories of breastfeeding duration were tested using ANCOVA after adjusting for a set of potential confounders: gestational and current age, birth weight, sexual maturation, fat mass, fat-free mass, maternal education, parental weight status, country, smoking behavior, and days of vigorous physical activity. Longer breastfeeding (either any or exclusive) was associated with a higher performance in the standing long jump test in both boys and girls (P < 0.001), regardless of fat mass, fat-free mass, and the rest of potential confounders. In adolescents who were breastfed for 3-5 mo or ≥6 mo, the risk of having a standing long jump performance below the 5th percentile was reduced by half compared with those who were never breastfed [odds ratio (OR) = 0.54, 95% CI = 0.30-0.96, P < 0.05; and OR = 0.40, 95% CI = 0.22-0.74, P < 0.01, respectively). These findings suggest a role of breastfeeding in determining lower body explosive strength during adolescence.
Published: 2010

62. Reliability and validity of the Adolescent Stress Questionnaire in a sample of European adolescents--the HELENA study

Author: De Vriendt, Tineke, Clays, Els, Moreno, Luis A, Bergman, Patrick, Vicente Rodriguez, Germán, Nagy, Eniko, Dietrich, Sabine, Manios, Yannis, De Henauw, Stefaan, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Castelló S, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Jesús M, Bueno M, Pablo Rey López J, Iglesia I, Velasco P, Bel S, Gracia Marco LA, Mouratidou T, Wärnberg J, Nova E, Gómez S, Esperanza Díaz L, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Ortega FB, Ruiz JR, Artero G, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Hurtig Wennlöf A, Hallström L, Patterson E, Kwak L, Rizzo N, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, José Sánchez M, Thomas S, Allchurch E, Burgess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, Fircks Hv, Lilja Hallberg M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, José Gómez Lorente J, Cañada D, Urzanqui A, María Torres R, Navarro P., VITAGLIONE, PAOLA, European Commission, Research Foundation - Flanders, De Vriendt, Tineke, Clays, El, Moreno, Luis A, Bergman, Patrick, Vicente Rodriguez, Germán, Nagy, Eniko, Dietrich, Sabine, Manios, Yanni, De Henauw, Stefaan, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Jesús, M, Bueno, M, Pablo Rey López, J, Iglesia, I, Velasco, P, Bel, S, Gracia Marco, La, Mouratidou, T, Wärnberg, J, Nova, E, Gómez, S, Esperanza Díaz, L, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Ortega, Fb, Ruiz, Jr, Artero, G, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Hurtig Wennlöf, A, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, José Sánchez, M, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, Fircks, Hv, Lilja Hallberg, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, José Gómez Lorente, J, Cañada, D, Urzanqui, A, María Torres, R, Navarro, P., and Matthys, Christophe
Subjects: Male, medicine.medical_specialty, Adolescent, Intraclass correlation, Reproducibility of Result, CHILDREN, DETERMINANTS, SALIVARY ALPHA-AMYLASE, Stress, Cronbach's alpha, Surveys and Questionnaires, Medicine and Health Sciences, medicine, Criterion validity, Surveys and Questionnaire, Humans, Obesity, Psychiatry, Child, Reliability (statistics), GENDER-DIFFERENCES, business.industry, CORTISOL, Phychological, lcsh:Public aspects of medicine, PSYCHOPATHOLOGY, Public Health, Environmental and Occupational Health, Construct validity, Reproducibility of Results, HEALTHY LIFE-STYLE, lcsh:RA1-1270, METHODOLOGICAL ISSUES, Confirmatory factor analysis, Social Cla, Europe, INDIVIDUALS, Social Class, Scale (social sciences), NUTRITION, Female, business, Stress, Psychological, Human, Clinical psychology, Psychopathology, Research Article
Abstract: The HELENA Study Group: et al., [Background]: Since stress is hypothesized to play a role in the etiology of obesity during adolescence, research on associations between adolescent stress and obesity-related parameters and behaviours is essential. Due to lack of a well-established recent stress checklist for use in European adolescents, the study investigated the reliability and validity of the Adolescent Stress Questionnaire (ASQ) for assessing perceived stress in European adolescents., [Methods]: The ASQ was translated into the languages of the participating cities (Ghent, Stockholm, Vienna, Zaragoza, Pecs and Athens) and was implemented within the HELENA cross-sectional study. A total of 1140 European adolescents provided a valid ASQ, comprising 10 component scales, used for internal reliability (Cronbach α) and construct validity (confirmatory factor analysis or CFA). Contributions of socio-demographic (gender, age, pubertal stage, socio-economic status) characteristics to the ASQ score variances were investigated. Two-hundred adolescents also provided valid saliva samples for cortisol analysis to compare with the ASQ scores (criterion validity). Test-retest reliability was investigated using two ASQ assessments from 37 adolescents., [Results]: Cronbach α-values of the ASQ scales (0.57 to 0.88) demonstrated a moderate internal reliability of the ASQ, and intraclass correlation coefficients (0.45 to 0.84) established an insufficient test-retest reliability of the ASQ. The adolescents' gender (girls had higher stress scores than boys) and pubertal stage (those in a post-pubertal development had higher stress scores than others) significantly contributed to the variance in ASQ scores, while their age and socio-economic status did not. CFA results showed that the original scale construct fitted moderately with the data in our European adolescent population. Only in boys, four out of 10 ASQ scale scores were a significant positive predictor for baseline wake-up salivary cortisol, suggesting a rather poor criterion validity of the ASQ, especially in girls., [Conclusions]: In our European adolescent sample, the ASQ had an acceptable internal reliability and construct validity and the adolescents' gender and pubertal stage systematically contributed to the ASQ variance, but its test-retest reliability and criterion validity were rather poor. Overall, the utility of the ASQ for assessing perceived stress in adolescents across Europe is uncertain and some aspects require further examination., The HELENA Study takes place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034). Tineke De Vriendt is financially supported by the Research Foundation - Flanders (Grant number: 1.1.746.09.N.01).
Published: 2010

63. Sedentary patterns and media availability in European adolescents: The HELENA study

Author: Rey López, Juan P., Vicente Rodriguez, Germán, Ortega, Francisco B., Ruiz, Jonatan R., Martinez Gómez, David, De Henauw, Stefan, Manios, Yannis, Molnar, Denes, Polito, Angela, Verloigne, Maite, Castillo, Manuel J., Sjöström, Michael, De Bourdeaudhuij, Ilse, Moreno, Luis A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Garzón MJ, Sáinz AG, Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz CS, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Boriss Riedl BK, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Pavón M, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Rey López, Juan P., Vicente Rodriguez, Germán, Ortega, Francisco B., Ruiz, Jonatan R., Martinez Gómez, David, De Henauw, Stefan, Manios, Yanni, Molnar, Dene, Polito, Angela, Verloigne, Maite, Castillo, Manuel J., Sjöström, Michael, De Bourdeaudhuij, Ilse, Moreno, Luis A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Garzón, Mj, Sáinz, Ag, Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Boriss Riedl, Bk, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Pavón, M, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.
Subjects: Gerontology, Male, medicine.medical_specialty, Media, Youth, European community, Adolescent, Epidemiology, Child health, Video Game, medicine, Prevalence, Humans, Sex Distribution, Socioeconomics, Child, Socioeconomic status, Sedentarine, Preventive healthcare, Sedentary lifestyle, Working life, business.industry, Medicine (all), Public Health, Environmental and Occupational Health, Social research, Europe, Video Games, Adolescent Behavior, Sedentary Lifestyle, Christian ministry, Female, Television, Sedentary Behavior, business, Inactivity, Leisure-time, Human
Abstract: Objective: To describe sedentary behaviors in adolescents and to examine the influence of media availability on TV viewing. Method: The study assessed 3278 adolescents (1537 males and 1741 females, 12.5-17.5. years) involved in the HELENA study (2007). Adolescents reported hours of TV viewing, computer games, console, internet for study and non-study reasons, and study, as well as availability of TVs, computers and consoles. Results: Time spent in sedentary behaviors was higher during weekends (all . p2. h/day) based solely on TV viewing, whereas around 60% exceeded it at weekends. Having a TV or a console in the bedroom was associated with higher TV viewing (OR. =2.66; 95% CI 2.23-3.18; and OR. =1.92; 95% CI 1.61-2.28, respectively) whereas the presence of computer reduced it (OR. =0.57; 95% CI 0.48-0.68). Conclusion: Adolescents living in Europe are not meeting media recommendations, especially during weekend. The absence of a TV in the adolescents' bedroom might reduce TV viewing. Further studies are needed to confirm or contrast our findings. © 2010 Elsevier Inc., The HELENA Study was carried out with ﬁnancial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034). This study was also supported by a grant from the Spanish Ministry of Health: Maternal, Child Health and Development Network (number RD08/0072) and the Spanish Ministry of Education (EX-2007-1124, EX-2008-0641, DEP2007- 29933-E, AP2006-02464), Swedish Council for Working Life and Social Research, the ALPHA study and the Swedish Heart Lung Foundation (20090635). JP Rey-López was supported by Fundación Cuenca Villoro (Spain).
Published: 2010

64. Recommended levels and intensities of physical activity to avoid low-cardiorespiratory fitness in European adolescents: The HELENA study

Author: Martinez Gomez, David, Ruiz, Jonatan R., Ortega, Francisco B., Casajús, Jose A., Veiga, Oscar L., Widhalm, Kurt, Manios, Yannis, Béghin, Laurent, González Gross, Marcela, Kafatos, Anthony, España Romero, Vanesa, Molnar, Denes, Moreno, Luis A., Marcos, Ascension, Castillo, Manuel J., Sjöström, Michael, Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Martinez Gomez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Sáinz AG, Ortega Porcel FB, Ruiz JR, Artero EG, Romero VE, Pavón DJ, Muñoz CS, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrı L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Jiménez Pavón D, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Lorente J.J., VITAGLIONE, PAOLA, Martinez Gomez, David, Ruiz, Jonatan R., Ortega, Francisco B., Casajús, Jose A., Veiga, Oscar L., Widhalm, Kurt, Manios, Yanni, Béghin, Laurent, González Gross, Marcela, Kafatos, Anthony, España Romero, Vanesa, Molnar, Dene, Moreno, Luis A., Marcos, Ascension, Castillo, Manuel J., Sjöström, Michael, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martinez Gomez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Sáinz, Ag, Ortega Porcel, Fb, Ruiz, Jr, Artero, Eg, Romero, Ve, Pavón, Dj, Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrı, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Jiménez Pavón, D, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Lorente, J. J.
Subjects: Male, medicine.medical_specialty, Adolescent, Physical activity, Sex Factor, Sex Factors, Oxygen Consumption, Genetic, Genetics, Hum, Medicine, Humans, Body Weights and Measures, Exercise, Ecology, Evolution, Behavior and Systematics, Receiver operating characteristic, business.industry, Medicine (all), Cardiorespiratory fitness, Body Weights and Measure, Odds ratio, Ecology, Evolution, Behavior and Systematic, Europe, Physical Fitness, Anthropology, Physical therapy, Physical Fitne, Female, Anatomy, business, Demography, Human
Abstract: Objectives: The purpose of this study was to determine the sex-specific physical activity (PA) intensity thresholds that best discriminate between unhealthy/healthy cardiorespiratory fitness (CRF). Methods: Participants included 1,808 adolescents (964 girls), aged 12.5–17.5 years, from the HELENA study. We measured PA by accelerometer and calculated the time spent at light, moderate, vigorous, and moderate-to-vigorous (MVPA) intensities. CRF was assessed by the 20-m shuttle-run test. Adolescents were dichotomized (unhealthy/healthy) based on sex- and age-specific FITNESSGRAM standards. Receiver operating characteristic (ROC) analysis was used to determine thresholds that best discriminate between CRF categories. Results: ROC analyses revealed that the PA thresholds that best discriminate between unhealthy/healthy CRF were ≥152, ≥33, ≥13, and ≥52 min/day in light, moderate, vigorous, and MVPA, respectively. In boys, the PA thresholds associated with a healthy CRF were ≥37, ≥19, and ≥56 min/day in moderate, vigorous, and MVPA, respectively, whereas in girls were ≥152, ≥34, ≥12, and ≥51 min/day in light, moderate, vigorous, and MVPA, respectively. Spending at least 60 min/day in MVPA was also associated with a healthy CRF (odds ratios: 1.75, 1.94, and 1.57, all P < 0.05, for the whole sample, boys, and girls, respectively). Conclusions: This study shows sex- and intensity-specific PA thresholds to discriminate between adolescents with a healthy CRF from those with a less favorable or unhealthy CRF level. Journal of Hospital Medicine. Society of Hospital Medicine. Am. J. Hum. Biol., 2010. © 2010 Wiley-Liss, Inc.
Published: 2010

65. Association of objectively assessed physical activity with total and central body fat in Spanish adolescents; The HELENA Study

Author: Moliner Urdiales, D., Ruiz, J. R., Ortega, F. B., Rey Lopez, J. P., Vicente Rodriguez, G., Espãa Romero, V., Munguía Izquierdo, D., Castillo, M. J., Sjöström, M., Moreno, L. A., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo Garzón MJ, Gutiérrez Sáinz A, Ortega Porcel FB, Ruiz JR, García Artero E, España Romero V, Jiménez Pavón D, Sánchez Muñoz C, Soto V, Chillón P, Heredia JM, Aparicio V, Baena P, Cardia CM, Carbonell A, Arcella D, Catasta G, Censi L, Ciarapica D, Ferrari M, Le Donne C, Leclerq C, Magrì L, Maiani G, Piccinelli R, Polito A, Spada R, Toti E, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Boriss Riedl BK, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Fievet N, Goumidi L, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castello S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesso I, Fernández L, Smillie L, Wills J, Meléndez A, Benito PJ, Calderón J, Valtueña J, Navarro P, Urzanqui A, Albers U, Pedrero R, Gómez Lorente J.J., VITAGLIONE, PAOLA, Moliner Urdiales, D., Ruiz, J. R., Ortega, F. B., Rey Lopez, J. P., Vicente Rodriguez, G., Espãa Romero, V., Munguía Izquierdo, D., Castillo, M. J., Sjöström, M., Moreno, L. A., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo Garzón, Mj, Gutiérrez Sáinz, A, Ortega Porcel, Fb, Ruiz, Jr, García Artero, E, España Romero, V, Jiménez Pavón, D, Sánchez Muñoz, C, Soto, V, Chillón, P, Heredia, Jm, Aparicio, V, Baena, P, Cardia, Cm, Carbonell, A, Arcella, D, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Le Donne, C, Leclerq, C, Magrì, L, Maiani, G, Piccinelli, R, Polito, A, Spada, R, Toti, E, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Boriss Riedl, Bk, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Fievet, N, Goumidi, L, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castello, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesso, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Male, medicine.medical_specialty, Waist, Adolescent, Endocrinology, Diabetes and Metabolism, Physical activity, Adipose tissue, Medicine (miscellaneous), Physical exercise, Motor Activity, Body composition, Absorptiometry, Photon, Negatively associated, Internal medicine, medicine, Nutrition and Dietetic, Humans, Obesity, Radionuclide Imaging, Child, Adiposity, DXA, Cross-Sectional Studie, Nutrition and Dietetics, business.industry, Medicine (all), Puberty, Total body, Lower intensity, medicine.disease, Accelerometer, Endocrinology, Cross-Sectional Studies, Adipose Tissue, Physical Fitness, Physical Fitne, Female, Waist Circumference, business, Human
Abstract: To examine the association of objectively assessed physical activity (PA) with markers of total and central body fat in adolescents, and to determine whether meeting the current PA recommendations (or = 60 min day(-1) of at least moderate intensity PA) is associated with reduced levels of total and central body fat.A total of 365 Spanish adolescents aged 12.5-17.5 years participated in this cross-sectional study. PA was assessed by accelerometry and expressed as average PA (counts per minute), and min day(-1) of light, moderate, moderate to vigorous (MVPA) and vigorous PA. MVPA was dichotomized into60 min day(-1) andor = 60. Total body fat was measured by DXA, BodPod and the sum of six skinfolds. Central body fat was measured by DXA at three regions (R1, R2 and R3), and waist circumference.All markers of central body fat were negatively associated with vigorous PA (P0.01) after controlling for sex, age and pubertal status. Abdominal adiposity measured at R1, R2 and R3 was also negatively associated with MVPA (Por = 0.001), and with average PA (P0.01). All markers of total body fat were negatively associated with vigorous PA (P0.01), MVPA (P0.01) and average PA (P0.05). Adolescents engaged on at least 60 min day(-1) MVPA presented lower levels of total (P0.05) and central body fat (Por = 0.01).The results suggest that vigorous PA may have a greater effect on preventing obesity in adolescents than does PA of lower intensity, whereas both average PA and at least moderate PA may have an impact on total and central body fat in youth.
Published: 2009

66. Identificación de QTl involucrados en la domesticación y evolución del melón

Author: Díaz Bermúdez, Aurora, Mohamed, M.A., Mercader, A., Reig, J.L., Martín Hernández, A.M., Dolçet Sanjuán, R., Alvarez Alvarez, José María, and Monforte, A.J.
Subjects: Cucumis melo, Genotipos, Identificación, Domesticación de plantas
Abstract: Published
Published: 2014

67. Biomarcadores precoces de fracaso renal agudo tras angiografía coronaria o cirugía cardíaca en pacientes con síndrome coronario o fallo cardíaco agudos

Author: Torregrosa, I., Montoliu, C., Urios, A., Elmlili, N., Puchades, M.J., Solís, M.A., Sanjuán, R., Blasco, M.L., Ramos, C., Tomás, P., Ribes, J., Carratalá, A., and Miguel, A.
Subjects: Coronary angiography, Interleukin-18, Heart failure, Cardiac surgery, Angiografía coronaria, Fracaso renal agudo, Cistatina-C, Acute kidney injury, Fallo cardíaco, Interleukina-18, Síndrome coronario agudo, Cirugía cardíaca, Acute coronary syndrome, NGAL, Cystatin C
Abstract: Antecedentes: El fracaso renal agudo (FRA) es una complicación frecuente tras la cirugía cardíaca y la angiografía coronaria que ensombrece el pronóstico de estos pacientes. El diagnóstico se basa en el ascenso de la creatinina sérica, que es tardío. Es necesaria la identificación y validación de nuevos biomarcadores precoces que permitan intervenciones más tempranas y eficaces. Objetivos: Evaluar la sensibilidad y especificidad de interleuquina-18 (IL-18) en orina, neutrophil gelatinase-associated lipocalin en orina (uNGAL) y cistatina C en suero para la detección precoz del FRA en una población de pacientes con síndrome coronario agudo o fallo cardíaco y sometidos a cirugía cardíaca o cateterismo. Métodos: Se incluyeron en el estudio 135 pacientes ingresados en una unidad de cuidados intensivos por síndrome coronario agudo o fallo cardíaco por patología coronaria o valvular y a los que se realizaron una angiografía cardíaca o una cirugía cardíaca de revascularización o recambio valvular. Se determinaron los biomarcadores a las 12 horas de la intervención y se monitorizó la creatinina sérica durante los siguientes seis días para el diagnóstico del FRA. Resultados: Para NGAL se obtuvo un área bajo la curva ROC (AUC) de 0,983 y para cistatina C e IL-18 de 0,869 y 0,727, respectivamente. Para un punto de corte de NGAL en orina de 31,9 ng/ml la sensibilidad fue del 100% y la especificidad del 91%. Conclusiones: uNGAL es un marcador precoz de FRA en pacientes con síndrome coronario o fallo cardíaco agudo y sometidos a cirugía cardíaca y angiografía cardíaca, con una capacidad predictiva superior a cistatina o a IL-18. Background: Acute kidney injury (AKI) is a common complication in cardiac surgery and coronary angiography, which worsens patients' prognosis. The diagnosis is based on the increase in serum creatinine, which is delayed. It is necessary to identify and validate new biomarkers that allow for early and effective interventions. Aims: To assess the sensitivity and specificity of neutrophil gelatinase-associated lipocalin in urine (uNGAL), interleukin-18 (IL-18) in urine and cystatin C in serum for the early detection of AKI in patients with acute coronary syndrome or heart failure, and who underwent cardiac surgery or catheterization. Methods: The study included 135 patients admitted to the intensive care unit for acute coronary syndrome or heart failure due to coronary or valvular pathology and who underwent coronary angiography or cardiac bypass surgery or valvular replacement. The biomarkers were determined 12 hours after surgery and serum creatinine was monitored during the next six days for the diagnosis of AKI. Results: The area under the ROC curve (AUC) for NGAL was 0.983, and for cystatin C and IL-18 the AUCs were 0.869 and 0.727, respectively. At a cut-off of 31.9ng/ml for uNGAL the sensitivity was 100% and the specificity was 91%. Conclusions: uNGAL is an early marker of AKI in patients with acute coronary syndrome or heart failure and undergoing cardiac surgery and coronary angiography, with a higher predictive value than cystatin C or IL-18.
Published: 2012

68. Biomarcadores precoces de fracaso renal agudo tras angiografía coronaria o cirugía cardíaca en pacientes con síndrome coronario o fallo cardíaco agudos

Author: Torregrosa,I., Montoliu,C., Urios,A., Elmlili,N., Puchades,M.J., Solís,M.A., Sanjuán,R., Blasco,M.L., Ramos,C., Tomás,P., Ribes,J., Carratalá,A., and Miguel,A.
Subjects: Fallo cardíaco, Interleukina-18, Síndrome coronario agudo, Cirugía cardíaca, NGAL, Angiografía coronaria, Fracaso renal agudo, Cistatina-C
Abstract: Antecedentes: El fracaso renal agudo (FRA) es una complicación frecuente tras la cirugía cardíaca y la angiografía coronaria que ensombrece el pronóstico de estos pacientes. El diagnóstico se basa en el ascenso de la creatinina sérica, que es tardío. Es necesaria la identificación y validación de nuevos biomarcadores precoces que permitan intervenciones más tempranas y eficaces. Objetivos: Evaluar la sensibilidad y especificidad de interleuquina-18 (IL-18) en orina, neutrophil gelatinase-associated lipocalin en orina (uNGAL) y cistatina C en suero para la detección precoz del FRA en una población de pacientes con síndrome coronario agudo o fallo cardíaco y sometidos a cirugía cardíaca o cateterismo. Métodos: Se incluyeron en el estudio 135 pacientes ingresados en una unidad de cuidados intensivos por síndrome coronario agudo o fallo cardíaco por patología coronaria o valvular y a los que se realizaron una angiografía cardíaca o una cirugía cardíaca de revascularización o recambio valvular. Se determinaron los biomarcadores a las 12 horas de la intervención y se monitorizó la creatinina sérica durante los siguientes seis días para el diagnóstico del FRA. Resultados: Para NGAL se obtuvo un área bajo la curva ROC (AUC) de 0,983 y para cistatina C e IL-18 de 0,869 y 0,727, respectivamente. Para un punto de corte de NGAL en orina de 31,9 ng/ml la sensibilidad fue del 100% y la especificidad del 91%. Conclusiones: uNGAL es un marcador precoz de FRA en pacientes con síndrome coronario o fallo cardíaco agudo y sometidos a cirugía cardíaca y angiografía cardíaca, con una capacidad predictiva superior a cistatina o a IL-18.
Published: 2012

69. The effect of ribavirin on the mutation rate and spectrum of hepatitis C virus in vivo

Author: Cuevas, J, González-Candelas, F, Moya, A, and Sanjuán, R
Published: 2009

70. Food Consumption and Screen-Based Sedentary Behaviors in European Adolescents

Author: Santaliestra Pasías, Alba M, Mouratidou, Theodora, Verbestel, Vera, Huybrechts, Inge, Gottrand, Frederic, Le Donne, Cinzia, Cuenca García, Magdalena, Díaz, Ligia E., Kafatos, Anthony, Manios, Yannis, Molnar, Deńes, Sjos̈tröm, Michael, Widhalm, Kurt, De Bourdeaudhuij, Ilse, Moreno, Luis A., De Henauw S, González Gross M, Gilbert C, Kafatos A, Moreno LA, Libersa C, Castelló S, Gottrand F, Kersting M, Sjöström M, Molnar D, Dallongeville J, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marco LA, Mouratidou T, Marcos A, Wärnberg J, Nova E, Romeo J, Veses A, Zapatera B, Pozo T, Martínez D, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster A, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Ortega FB, Ruiz JR, Artero EG, España V, Jiménez Pavón D, Chillón P, Sánchez Muñoz C, Cuenca García M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Consta O, Moschonis G, Papoutsou S, Bellou E, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Wennlöf AH, Kwak L, Rizzo N, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Thomas S, Allchurch E, Burgess P, Hall G, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Lorente JJ, Cañada D, Urzanqui A, Torres RM, Navarro P, Tomás C, Mesana MI, Lázaro A, Gómez S, Díaz LE, Gutiérrez À, D. Acapito P, De Bourdeaudhuij I, Ottevaere C, Huybrechts I, Eleutheriou S, Katsaroli I, Kraniou G, Keke D, Petraki I, Tanagra S, Hagströmer M, Hallström L, Patterson E., VITAGLIONE, PAOLA, Santaliestra Pasías, Alba M, Mouratidou, Theodora, Verbestel, Vera, Huybrechts, Inge, Gottrand, Frederic, Le Donne, Cinzia, Cuenca García, Magdalena, Díaz, Ligia E., Kafatos, Anthony, Manios, Yanni, Molnar, Deńe, Sjos̈tröm, Michael, Widhalm, Kurt, De Bourdeaudhuij, Ilse, Moreno, Luis A., De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Moreno, La, Libersa, C, Castelló, S, Gottrand, F, Kersting, M, Sjöström, M, Molnar, D, Dallongeville, J, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marco, La, Mouratidou, T, Marcos, A, Wärnberg, J, Nova, E, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, A, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Jiménez Pavón, D, Chillón, P, Sánchez Muñoz, C, Cuenca García, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, Ferrari, M, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Consta, O, Moschonis, G, Papoutsou, S, Bellou, E, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Wennlöf, Ah, Kwak, L, Rizzo, N, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Thomas, S, Allchurch, E, Burgess, P, Hall, G, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Lorente, Jj, Cañada, D, Urzanqui, A, Torres, Rm, Navarro, P, Tomás, C, Mesana, Mi, Lázaro, A, Gómez, S, Díaz, Le, Gutiérrez, À, D., Acapito P, De Bourdeaudhuij, I, Ottevaere, C, Huybrechts, I, Eleutheriou, S, Katsaroli, I, Kraniou, G, Keke, D, Petraki, I, Tanagra, S, Hagströmer, M, Hallström, L, and Patterson, E.
Subjects: Male, Television viewing, Adolescent, Logistic Model, Cross-sectional study, Health Behavior, education, Food consumption, Diet Surveys, Childhood obesity, Body Mass Index, Odds, Video Game, Odds Ratio, medicine, Humans, Child, Recreation, Cross-Sectional Studie, Internet, business.industry, Odds ratio, medicine.disease, Diet, Social Cla, Diet Survey, Europe, Cross-Sectional Studies, Logistic Models, Social Class, Video Games, Adolescent Behavior, Sedentary Lifestyle, Pediatrics, Perinatology and Child Health, Female, Television, Self Report, Sedentary Behavior, business, human activities, Body mass index, Human, Demography
Abstract: OBJECTIVE:To examine the association between time spent on different sedentary behaviors and consumption of certain food and beverage groups in a sample of European adolescents. DESIGN:Data from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-sectional Study. SETTING:Eight survey centers (Athens, Dortmund, Ghent, Lille, Rome, Stockholm, Vienna, and Zaragoza). PARTICIPANTS:A total of 2202 participants (45.5% boys) aged 12¿ to 17¿ years. MAIN OUTCOME MEASURES:Information on sedentary behaviors (weekdays and weekends) collected via a standardized self-reported questionnaire, including watching television, playing computer and video games, using the Internet for studying or recreation, and studying. Food and beverage consumption data of selected groups were obtained using 2 nonconsecutive 24-hour recalls. RESULTS:Boys reporting more than 4 h/d of watching television, playing computer games, and using the Internet for recreation were more likely to consume sweetened beverages (weekends) (odds ratio [OR], 1.83 [95% CI, 1.21-2.75]; 1.99 [1.31-3.01]; and 1.73 [1.03-2.91], respectively), and less likely to consume fruit (weekdays) (0.39 [0.21-0.72], 0.37 [0.18-0.77], and 0.39 [0.19-0.78], respectively) than those who spent less than 2 h/d. Girls spending more time per day watching television and playing computer or video games (weekdays) and playing computer games or surfing the Internet for recreation (weekends) were more likely to drink sweetened beverages (OR, 1.89 [95% CI, 1.21-2.94]; 1.57 [1.00-2.46]; 2.14 [1.16-3.97]; and 2.30 [1.24-4.28], respectively) and less likely to consume fruit (weekdays) (0.43 [0.23-0.80], 0.40 [0.19-0.83], 0.37 [0.14-0.94], and 0.42 [0.20-0.85], respectively) than those who spent less than 2 h/d. CONCLUSION:Increased television viewing and computer and Internet use during adolescence is associated with higher odds of consumption of sweetened beverages and lower odds of fruit consumption.
Published: 2012
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71. Experimental evolution of plant RNA viruses

Author: Elena, S F, primary, Agudelo-Romero, P, additional, Carrasco, P, additional, Codoñer, F M, additional, Martín, S, additional, Torres-Barceló, C, additional, and Sanjuán, R, additional
Published: 2008
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72. Theory of Lethal Mutagenesis for Viruses

Author: Bull, J. J., primary, Sanjuán, R., additional, and Wilke, C. O., additional
Published: 2007
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73. Amebic liver abscess with bacterial superinfection in a patient with no epidemiologic risk factors

Author: Sánchez-Pobre, P., primary, Saénz-López, S., additional, Salto, E., additional, Sanjuán, R., additional, Ibero, C., additional, Masedo, A., additional, and Solís Herruzo, J. A., additional
Published: 2004
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74. Differential effects of vertical and horizontal transmission in the fitness of an RNA virus: A reanalysis

Author: Elena, Santiago F, primary, Sanjuán, R, additional, Borderı́a, A.V, additional, and Turner, Paul E, additional
Published: 2002
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75. Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure.

Author: Torregrosa, I., Montoliu, C., Urios, A., Elmlili, N., Juan, I., Puchades, M. J., Solís, M. A., Sanjuán, R., Blasco, M. L., Ramos, C., Tomás, P., Ribes, J., Carratalá, A., and Miguel, A.
Abstract: Background: Acute kidney injury (AKI) is a common complication in cardiac surgery and coronary angiography, which worsens patients’ prognosis. The diagnosis is based on the increase in serum creatinine, which is delayed. It is necessary to identify and validate new biomarkers that allow for early and effective interventions. Aims: To assess the sensitivity and specificity of neutrophil gelatinase-associated lipocalin in urine (uNGAL), interleukin-18 (IL-18) in urine and cystatin C in serum for the early detection of AKI in patients with acute coronary syndrome or heart failure, and who underwent cardiac surgery or catheterization. Methods: The study included 135 patients admitted to the intensive care unit for acute coronary syndrome or heart failure due to coronary or valvular pathology and who underwent coronary angiography or cardiac bypass surgery or valvular replacement. The biomarkers were determined 12 hours after surgery and serum creatinine was monitored during the next six days for the diagnosis of AKI. Results: The area under the ROC curve (AUC) for NGAL was 0.983, and for cystatin C and IL-18 the AUCs were 0.869 and 0.727, respectively. At a cut-off of 31.9ng/ml for uNGAL the sensitivity was 100% and the specificity was 91%. Conclusions: uNGAL is an early marker of AKI in patients with acute coronary syndrome or heart failure and undergoing cardiac surgery and coronary angiography, with a higher predictive value than cystatin C or IL-18. [ABSTRACT FROM AUTHOR]
Published: 2012
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76. Observations on variability of atrioventricular nodal conduction in man and the dual-pathway response.

Author: SANCHIS, J., LÓPEZ-MERINO, V., SANJUÁN, R., MORELL, S., CHORRO, F. J., GARCÍA-CIVERA, R., and LLÁCER, A.
Abstract: A study was made of nodal conduction times of atrial stimuli with fixed coupling intervals, in 23 patients divided into two groups according to their atrial stimulus test response: Group I (continuous AV node function curve; 17 cases) and Gruop II (dual AV node pathway; six cases). The stimulation protocol involved the delivery of 75 stimuli with a fixed coupling interval 20 ms greater than the effective refractory period (ERP) of the AV node (Group I) or fast pathway (Group II). The atrial coupling intervals (A1A2) and node conduction times (A2H2) were measured. An evaluation was made of the dispersion of intervals with range (R) and of the distribution of A2H2 times (χ test). In both Groups, R (A2H2) was greater than R(A1A2) (P<0.05): R(A2H2) in Group II was greater than R(A2H2) in Group I (P < 0.001). In Group I the distribution of A2H2 was non-normal in four cases and bimodal in five; in Group II the distribution was non-normal and bimodal in all cases. It is concluded that: (1) the AV node generates a dispersion in its conduction times in the vicinity of its ERP, although the nodal conduction curve is continuous: and (2) the so-called dual pathway may constitute an exaggeration of AV node response inhomogeneity. [ABSTRACT FROM PUBLISHER]
Published: 1988
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77. Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study

Author: Lin Y, Mouratidou T, Vereecken C, Kersting M, Bolca S, de Moraes AC, Cuenca García M, Moreno LA, González Gross M, Valtueña J, Labayen I, Grammatikaki E, Hallstrom L, Leclercq C, Ferrari M, Gottrand F, Beghin L, Manios Y, Ottevaere C, Van Oyen H, Molnar D, Kafatos A, Widhalm K, Gómez Martinez S, Prieto LE, De Henauw S, Huybrechts I, Gilbert C, Libersa C, Sánchez J, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel Serrat S, Gracia Marco L, Jiménez Pavón D, Marcos A, Wärnberg J, Nova E, Gómez Martínez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España V, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Galfo M, le Donne C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, de Maeyer M, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöström M, Ruiz J, Hagströmer M, Hallström L, Patterson E, Kwak L, Rizzo N, Hurtig Wennlöf A, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, Cárnicas Serrano SL, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Albers U, Pedrero R, Meléndez A, Benito PJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Gómez Lorente JJ, Mardía Torres R, Navarro P., VITAGLIONE, PAOLA, Lin, Y, Mouratidou, T, Vereecken, C, Kersting, M, Bolca, S, de Moraes, Ac, Cuenca García, M, Moreno, La, González Gross, M, Valtueña, J, Labayen, I, Grammatikaki, E, Hallstrom, L, Leclercq, C, Ferrari, M, Gottrand, F, Beghin, L, Manios, Y, Ottevaere, C, Van Oyen, H, Molnar, D, Kafatos, A, Widhalm, K, Gómez Martinez, S, Prieto, Le, De Henauw, S, Huybrechts, I, Gilbert, C, Libersa, C, Sánchez, J, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel Serrat, S, Gracia Marco, L, Jiménez Pavón, D, Marcos, A, Wärnberg, J, Nova, E, Gómez Martínez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Galfo, M, le Donne, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, de Maeyer, M, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöström, M, Ruiz, J, Hagströmer, M, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Hurtig Wennlöf, A, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, Cárnicas Serrano, Sl, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Gómez Lorente, Jj, Mardía Torres, R, Navarro, P., European Commission, Swedish Council for Working Life and Social Research, Ministerio de Educación (España), Ministerio de Sanidad y Consumo (España), Ministerio de Ciencia e Innovación (España), Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), and Matthys, Christophe
Subjects: Male, NUTRITION AND DIETETICS, CHILDHOOD, Medicine (miscellaneous), Overweight, Body fat percentage, Body Mass Index, clinical-trial, fat, Medicine and Health Sciences, HELENA cross-sectional study, dietary proteins, adolescence, Child, treat obesity, Plant Proteins, 2. Zero hunger, Nutrition and Dietetics, Anthropometry, Age Factors, Lipids, Diet Records, 3. Good health, Europe, Plant protein, HELENA study, Female, Dietary Proteins, medicine.symptom, Underweight, Life Sciences & Biomedicine, energy, medicine.medical_specialty, Meat, Adolescent, Clinical nutrition, Sex Factors, Thinness, children, Internal medicine, Environmental health, medicine, body-weight, Animals, Humans, overweight, Obesity, Exercise, body composition, Science & Technology, Nutrition & Dietetics, business.industry, MEDICINE, Research, biomarkers, medicine.disease, protein intake, disease risk, Diet, chilhood, Endocrinology, Cross-Sectional Studies, Nutrition Assessment, adolescence, business, Energy Intake, nutritional-status, Body mass index
Abstract: Lin, Y. et al., [Background] Previous studies suggest that dietary protein might play a beneficial role in combating obesity and its related chronic diseases. Total, animal and plant protein intakes and their associations with anthropometry and serum biomarkers in European adolescents using one standardised methodology across European countries are not well documented., [Objectives] To evaluate total, animal and plant protein intakes in European adolescents stratified by gender and age, and to investigate their associations with cardio-metabolic indicators (anthropometry and biomarkers)., [Methods] The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006–2007) aged 12.5-17.5 y (47% males) who completed two non-consecutive computerised 24-h dietary recalls. Associations between animal and plant protein intakes, and anthropometry and serum biomarkers were examined with General linear Model multivariate analysis., [Results] Average total protein intake exceeded the recommendations of World Health Organization and European Food Safety Authority. Mean total protein intake was 96 g/d (59% derived from animal protein). Total, animal and plant protein intakes (g/d) were significantly lower in females than in males and total and plant protein intakes were lower in younger participants (12.5-14.9 y). Protein intake was significantly lower in underweight subjects and higher in obese ones; the direction of the relationship was reversed after adjustments for body weight (g/(kg.d)). The inverse association of plant protein intakes was stronger with BMI z-score and body fat percentage (BF%) compared to animal protein intakes. Additionally, BMI and BF% were positively associated with energy percentage of animal protein., [Conclusions] This sample of European adolescents appeared to have adequate total protein intake. Our findings suggest that plant protein intakes may play a role in preventing obesity among European adolescents. Further longitudinal studies are needed to investigate the potential beneficial effects observed in this study in the prevention of obesity and related chronic diseases., The HELENA-study took place with the financial support of the European Community Sixth RTD Framework Programme. This work was also partially supported by the European Union in the framework of the Public Health Programme, the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education, and the Spanish Ministry of Health, Maternal, Child Health and Development Network and the Spanish Ministry of Science and Innovation AGL2007-29784-E. The content of this paper reflect only the authors' views and the rest of HELENA-study members and the European Community is not liable for any use that may be made of the information contained therein. Augusto César F. de Moraes is in receipt of a PhD scholarship from the São Paulo State Research Foundation (FAPESP: proc. 2011/11137-1 and 2011/20662-2) and Postdoctoral Research Fellow scholarship from National Counsel of Technological and Scientific Development (CNPq: proc. 313772/2014-2); Luis A. Moreno was given scholarship of Visiting Professor from Brazilian government by Science without Borders Program by CNPq and CAPES (Coordination of Improvement of Higher Education Personnel) (proc. 007/2012). The GENUD Research Group co-financed by the European Regional Development Fund (MICINN-FEDER). Many thanks to Petra Pickert, Anke Carstensen and Rosa Maria Torres for their contribution to laboratory work.
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78. Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study

Author: Benser, J., Valtueña, J., Ruiz, J. R., Mielgo-Ayuso, J., Breidenassel, C., Vicente-Rodriguez, G., Ferrari, M., Widhalm, K., Manios, Y., Sjöström, M., Molnar, D., Gómez-Martínez, S., Kafatos, A., Palacios, G., Moreno, L. A., Castillo, M. J., Stehle, P., González-Gross, M., Helena Study Group, Gottrand, F., Henauw, S., Gilbert, C., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., López, J. P. R., Iglesia, I., Velasco, P., Bel, S., Marcos, A., Wärnberg, J., Nova, E., Díaz, E. L., Romeo, J., Veses, A., Puertollano, M. A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Sbokos, C. V. M., Protoyeraki, E., Fasoulaki, M., Pietrzik, K., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Garzón, M. J. C., Sáinz, Á G., Porcel, F. B. O., Artero, E. G., Romero, V. E., Pavón, D. J., Muñoz, C. S., Soto, V., Chillón, P., Heredia, J. M., Virginia A Aparicio, Baena, P., Cardia, C. M., Carbonell, A., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D’acapito, P., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., Bourdeaudhuij, I., Vriendt, T., Matthys, C., Vereecken, C., Maeyer, M., Ottevaere, C., Huybrechts, I., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A. H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Benito, P. J., Lorente, J. J. G., Cañada, D., Urzanqui, A., Ortiz, J. C., Fuentes, F., Jiménez-Pavón, D., Albers, U., Ayuso, J. M., Torres, R. M., and Navarro, P.

79. The effect of genetic robustness on evolvability in digital organisms

Author: Sanjuán Rafael and Elena Santiago F
Subjects: Evolution, QH359-425
Abstract: Abstract Background Recent work has revealed that many biological systems keep functioning in the face of mutations and therefore can be considered genetically robust. However, several issues related to robustness remain poorly understood, such as its implications for evolvability (the ability to produce adaptive evolutionary innovations). Results Here, we use the Avida digital evolution platform to explore the effects of genetic robustness on evolvability. First, we obtained digital organisms with varying levels of robustness by evolving them under combinations of mutation rates and population sizes previously shown to select for different levels of robustness. Then, we assessed the ability of these organisms to adapt to novel environments in a variety of experimental conditions. The data consistently support that, for simple environments, genetic robustness fosters long-term evolvability, whereas, in the short-term, robustness is not beneficial for evolvability but may even be a counterproductive trait. For more complex environments, however, results are less conclusive. Conclusion The finding that the effect of robustness on evolvability is time-dependent is compatible with previous results obtained using RNA folding algorithms and transcriptional regulation models. A likely scenario is that, in the short-term, genetic robustness hampers evolvability because it reduces the intensity of selection, but that, in the long-term, relaxed selection facilitates the accumulation of genetic diversity and thus, promotes evolutionary innovation.
Published: 2008
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80. Topology testing of phylogenies using least squares methods

Author: Wróbel Borys, González-Candelas Fernando, Sanjuán Rafael, and Czarna Aleksandra
Subjects: Evolution, QH359-425
Abstract: Abstract Background The least squares (LS) method for constructing confidence sets of trees is closely related to LS tree building methods, in which the goodness of fit of the distances measured on the tree (patristic distances) to the observed distances between taxa is the criterion used for selecting the best topology. The generalized LS (GLS) method for topology testing is often frustrated by the computational difficulties in calculating the covariance matrix and its inverse, which in practice requires approximations. The weighted LS (WLS) allows for a more efficient albeit approximate calculation of the test statistic by ignoring the covariances between the distances. Results The goal of this paper is to assess the applicability of the LS approach for constructing confidence sets of trees. We show that the approximations inherent to the WLS method did not affect negatively the accuracy and reliability of the test both in the analysis of biological sequences and DNA-DNA hybridization data (for which character-based testing methods cannot be used). On the other hand, we report several problems for the GLS method, at least for the available implementation. For many data sets of biological sequences, the GLS statistic could not be calculated. For some data sets for which it could, the GLS method included all the possible trees in the confidence set despite a strong phylogenetic signal in the data. Finally, contrary to WLS, for simulated sequences GLS showed undercoverage (frequent non-inclusion of the true tree in the confidence set). Conclusion The WLS method provides a computationally efficient approximation to the GLS useful especially in exploratory analyses of confidence sets of trees, when assessing the phylogenetic signal in the data, and when other methods are not available.
Published: 2006
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81. Ventricular tachycardia in Duchenne's muscular dystrophy

Author: Muñoz, J., Sanjuan, R., Morell, J.S., and Ibañez, M.
Published: 1996
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82. 4.P.61 Metabolic study in acute myocardial infarction survivors without diabetes mellitus

Author: Galindo, M.J., SanJuan, R., Morillas, C., and Hernández, A.
Published: 1997
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83. Correlates of ideal cardiovascular health in European adolescents: The HELENA study

Author: P. Henriksson, H. Henriksson, I. Labayen, I. Huybrechts, L. Gracia-Marco, F.B. Ortega, V. España-Romero, Y. Manios, M. González-Gross, A. Marcos, L.A. Moreno, Á. Gutiérrez, J.R. Ruiz, F. Gottrand, S. De Henauw, C. Gilbert, A. Kafatos, C. Libersa, J. Sánchez, M. Kersting, M. Sjöstrom, D. Molnár, J. Dallongeville, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J. Revenga, C. Lachen, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, J.P. Rey López, I. Iglesia, P. Velasco, S. Bel, J. Wärnberg, E. Nova, S. Gómez-Martinez, L.E. Díaz, J. Romeo, A. Veses, M.A. Puertollano, B. Zapatera, T. Pozo, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, D. Molnar, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Repásy, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, E.G. Artero, D. Jiménez-Pavón, P. Chillón, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, L. Censi, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, K. Widhalm, K. Phillipp, S. Dietrich, B. Kubelka, M. Boriss-Riedl, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, K. Kondaki, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, P. Bergman, M. Hagströmer, L. Hallström, M. Hallberg, E. Poortvliet, N. Rizzo, L. Beckman, A.H. Wennlöf, E. Patterson, L. Kwak, L. Cernerud, P. Tillgren, S. Sörensen, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Castelló, S. Thomas, E. Allchurch, P. Burguess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, J. Valtueña, U. Albers, R. Pedrero, A. Meléndez, P.J. Benito, J. Calderón, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, J. Carlos Ortiz, F. Fuentes, R. María Torres, P. Navarro, European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Sanidad (España), Universidad de Granada, Swedish Society of Medicine, Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., Gracia-Marco, L., Ortega, F. B., España-Romero, V., Manios, Y., González-Gross, M., Marcos, A., Moreno, L. A., Gutiérrez, Ã ., Ruiz, J. R., Gottrand, F., De Henauw, S., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Rey López, J. P., Iglesia, I., Velasco, P., Bel, S., Wärnberg, J., Nova, E., Gómez-Martinez, S., Díaz, L. E., Romeo, J., Veses, A., Puertollano, M. A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Repásy, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Artero, E. G., Jiménez-Pavón, D., Chillón, P., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A. H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, J., Albers, U., Pedrero, R., Meléndez, A., Benito, P. J., Calderón, J., Gómez Lorente, J. J., Cañada, D., Urzanqui, A., Carlos Ortiz, J., Fuentes, F., María Torres, R., and Navarro, P.
Subjects: Blood Glucose, Male, Health Knowledge, Attitudes, Practice, Adolescent, Epidemiology, Health Status, Endocrinology, Diabetes and Metabolism, Health Behavior, Ideal Body Weight, Medicine (miscellaneous), Blood Pressure, Health Promotion, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, Health Status Indicators, Humans, Socioeconomic statu, Healthy Lifestyle, 030212 general & internal medicine, Exercise, Public health, Nutrition and Dietetics, Prevention, Smoking, Age Factors, Protective Factors, Cardiovascular health, Europe, Primary Prevention, Cholesterol, Cross-Sectional Studies, Adolescent Behavior, Cardiovascular Diseases, Television, Female, Risk factor, Diet, Healthy, Cardiology and Cardiovascular Medicine, Biomarkers
Abstract: On behalf of the HELENA Study Group., [Background and aims]: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents., [Methods and results]: The study comprised 637 European adolescents with complete iCVH data. Participants were part of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional, multicenter study conducted in 9 different European countries. Correlates investigated were sex and age, family affluence scale, maternal education, geographic location, sleep time, television viewing, duration of pregnancy, birth weight and breastfeeding. Younger adolescents, those whose mothers had medium/high education or those who watched television less than 2 h per day had a greater number of iCVH components compared to those who were older, had a mother with low education or watched television 2 h or more daily (P ≤ 0.01)., [Conclusion]: Since in our study older adolescents had worse iCVH than younger adolescents, early promotion of cardiovascular health may be important. Future studies may also investigate the usefulness of limiting television viewing to promote iCVH. Finally, since adolescents of mothers with low education had poorer iCVH, it may be of special interest to tailor public health promotion to adolescents from families with low socioeconomic status., The HELENA project was supported by the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). The data for this study was gathered under the aegis of the HELENA project, and further analysis was additionally supported by the Spanish Ministry of Economy and Competitiveness (grants RYC-2010-05957 and RYC-2011-09011), the Spanish Ministry of Health: Maternal, Child Health and Development Network (grant RD16/0022), the Fondo Europeo de Desarrollo Regional (MICINN-FEDER) and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES). Pontus Henriksson was supported by a grant from Henning and Johan Throne-Holst Foundation. Hanna Henriksson was supported by grants from the Swedish Society of Medicine and the County Council of Östergötland, Sweden. Dr. Gracia-Marco acknowledges “Programa de Captación de Talento - UGR Fellows” as part of “Plan Propio” of the University of Granada (Spain).
Published: 2018

84. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author: E.M. González-Gil, C. Cadenas-Sanchez, J. Santabárbara, G. Bueno-Lozano, I. Iglesia, M. González-Gross, D. Molnar, F. Gottrand, S. De Henauw, A. Kafatos, K. Widhalm, Y. Manios, A. Siani, F. Amaro-Gahete, A.I. Rupérez, D. Cañada, L. Censi, M. Kersting, J. Dallongeville, A. Marcos, F.B. Ortega, L.A. Moreno, C. Gilbert, C. Libersa, S. Castelló, M. Sjöstrom, D. Molnár, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, I. Labayen, S. Bel Serrat, L.A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, P. De Miguel-Etayo, C. Julián Almárcegui, M. Miguel-Berges, I. Iguacel, J. Wärnberg, E. Nova, S. Gómez, L.E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, Á. Gutiérrez, J.R. Ruiz, E.G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, I. Huybrechts, K. Phillipp, S. Dietrich, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, M. Hagströmer, A.H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Thomas, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P.J. Benito, J.J. Gómez Lorente, A. Urzanqui, R.M. Torres, P. Navarro, González-Gil, E. M., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Iglesia, I., González-Gross, M., Molnar, D., Gottrand, F., De Henauw, S., Kafatos, A., Widhalm, K., Manios, Y., Siani, A., Amaro-Gahete, F., Rupérez, A. I., Cañada, D., Censi, L., Kersting, M., Dallongeville, J., Marcos, A., Ortega, F. B., Moreno, L. A., Gilbert, C., Libersa, C., Castelló, S., Sjöstrom, M., Molnár, D., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. Ma, Bueno, M., Labayen, I., Bel Serrat, S., Gracia Marco, L. A., Mouratidou, T., Santaliestra-Pasías, A., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Wärnberg, J., Nova, E., Gómez, S., Díaz, L. E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, Ã ., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Phillipp, K., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A. H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P. J., Gómez Lorente, J. J., Urzanqui, A., Torres, R. M., Navarro, P., Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Stockholm County Council, and Ministerio de Ciencia e Innovación (España)
Subjects: Male, Pediatric Obesity, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Health Status, Physiology, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Body Mass Index, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, adolescents, Metabolic Syndrome, Nutrition and Dietetics, biology, Age Factors, Interleukin, Complement C4, Inflammatory biomarkers, Complement C3, Prognosis, Europe, C-Reactive Protein, Female, medicine.symptom, Inflammation Mediators, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Adolescent, Metabolic health, 030209 endocrinology & metabolism, Inflammation, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, business.industry, C-reactive protein, Case-control study, medicine.disease, Endocrinology, Blood pressure, Cross-Sectional Studies, Case-Control Studies, biology.protein, Metabolic syndrome, business, Body mass index, Inflammatory biomarker, Biomarkers
Abstract: On behalf of the HELENA study group., [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently., The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795).
Published: 2017
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85. Physical Activity Is Associated with Attention Capacity in Adolescents

Author: Jérémy Vanhelst, Laurent Béghin, Alain Duhamel, Yannis Manios, Denes Molnar, Sefaan De Henauw, Luis A. Moreno, Francisco B. Ortega, Michael Sjöström, Kurt Widhalm, Frédéric Gottrand, Fréderic Gottrand, Stefaan De Henauw, Marcela González-Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, Jackie Sánchez, Mathilde Kersting, Michael Sjöstrom, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, Pilar Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Revenga, Carmen Lachen, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús Mª Garagorri, Manuel Bueno, Juan Pablo Rey López, Iris Iglesia, Paula Velasco, Silvia Bel, Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez, Esperanza Ligia Díaz, Javier Romeo, Ana Veses, Mari Angeles Puertollano, Belén Zapatera, Tamara Pozo, David Martínez, Laurent Beghin, Catalina Iliescu, Juliana Von Berlepsch, Wolfgang Sichert-Hellert, Ellen Koeppen, Dénes Molnar, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Miklós Angster, Enikö Nagy, Orsolya Kovács, Judit Repásy, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas, Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J. Castillo, Ángel Gutiérrez, Jonatan R. Ruiz, Enrique G. Artero, Vanesa España-Romero, David Jiménez-Pavón, Palma Chillón, Magdalena Cuenca-García, Davide Arcella, Elena Azzini, Emma Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Raffaella Spada, Stefania Sette, Maria Zaccaria, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Christophe Matthys, Carine Vereecken, Mieke de Maeyer, Charlene Ottevaere, Inge Huybrechts, Katharina Phillipp, Sabine Dietrich, Birgit Kubelka, Marion Boriss-Riedl, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Katerina Kondaki, Stamatoula Tsikrika, Christos Karaiskos, Aline Meirhaeghe, Patrick Bergman, María Hagströmer, Lena Hallström, Mårten Hallberg, Eric Poortvliet, Nico Rizzo, Linda Beckman, Anita Hurtig Wennlöf, Emma Patterson, Lydia Kwak, Lars Cernerud, Per Tillgren, Stefaan Sörensen, Jackie Sánchez-Molero, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Sara Castelló, Sarah Thomas, Elaine Allchurch, Peter Burguess, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Agustín Meléndez, Pedro J. Benito, Javier Calderón, Jara Valtueña, Paloma Navarro, Alejandro Urzanqui, Ulrike Albers, Raquel Pedrero, Juan José Gómez Lorente, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Inserm, Université de Lille, CHU Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Vanhelst, Jérémy, Béghin, Laurent, Duhamel, Alain, Manios, Yanni, Molnar, Dene, De Henauw, Sefaan, Moreno, Luis A, Ortega, Francisco B, Sjöström, Michael, Widhalm, Kurt, Gottrand, Frédéric, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Cuenca García, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.
Subjects: Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Overweight, Motor Activity, 03 medical and health sciences, 0302 clinical medicine, medicine, D2 Test of Attention, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Aerobic exercise, Humans, Attention, 030212 general & internal medicine, Effects of sleep deprivation on cognitive performance, Child, Exercise, 2. Zero hunger, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, International Standard Classification of Education, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, Mesh:Adolescent, Mesh:Attention, Mesh:Child, Mesh:Cross-Sectional Studies, Mesh:Exercise, Mesh:Female, Mesh:Humans, Mesh:Male, Mesh:Motor Activity, 030229 sport sciences, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, medicine.symptom, business, Body mass index, Clinical psychology
Abstract: International audience; Objective: To assess the relationships among physical activity, measured objectively, and attention capacity in European adolescents.Study design: The study included 273 adolescents, aged 12.5-17.5 years, who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Participants wore a uniaxial accelerometer for 7 days to measure physical activity. The d2 Test of Attention was administered to assess attention capacity. Multivariate analyses were used to study the association of attention capacity with each measure of physical activity. Receiver operating characteristic analysis was performed to determine thresholds that best discriminate between low and good attention capacity.Results: After controlling for potential confounding variables (age, sex, body mass index, parental educational level, fat mass, aerobic fitness, and center), adolescents' attention capacity test performances were significantly and positively associated with longer time spent in moderate or moderate-to-vigorous physical activity (MVPA) in free-living conditions (P < .05). Receiver operating characteristic curve analyses revealed that the physical activity thresholds that best discriminated between low/good attention capacities were ≥41 min·day−1 for moderate, ≥12 min·day−1 for vigorous, and ≥58 min·day−1 for MVPA.Conclusion:These findings suggest that promoting MVPA may be have a beneficial effect on attention capacity, an important component of cognition, in adolescents.
Published: 2015
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86. Murine colon cancer derived cells exhibit heterogeneous resistance profiles against an oncolytic virus.

Author: Larrieux A and Sanjuán R
Subjects: Animals, Mice, Cell Line, Tumor, Immunity, Innate, Humans, Colonic Neoplasms therapy, Colonic Neoplasms pathology, Colonic Neoplasms virology, Oncolytic Viruses genetics, Oncolytic Viruses physiology, Oncolytic Virotherapy methods
Abstract: Oncolytic virotherapy has shown efficacy in various animal models and a few human cancers. However, there are still significant limitations for the implementation of these therapies. One such limitation is the emergence of cellular resistances, which may appear rapidly considering the high genetic heterogeneity of most tumors. We previously showed that cellular resistance to an oncolytic virus can be mediated by the chronic activation of innate immunity. Here, we explored the existence of additional resistance mechanisms in murine colon cancer-derived cells. For this purpose, we isolated two cellular clones that were resistant to the oncolytic virus VSV-D51. While one of the clones showed a strong resistance profile associated with increased cytokine-mediated antiviral responses, the other clone showed a lower level of resistance that involves cytoskeletal reorganization, signaling by small GTPases, and cell structural changes. These results demonstrate the capacity of tumor cells to deploy heterogeneous mechanisms of resistance to oncolytic viruses., (© 2024. The Author(s).)
Published: 2024
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87. Phylogenetic evidence supporting the nonenveloped nature of hepadnavirus ancestors.

Author: Buigues J, Viñals A, Martínez-Recio R, Monrós JS, Cuevas JM, and Sanjuán R
Subjects: Animals, Chiroptera virology, Evolution, Molecular, Feces virology, Genome, Viral, Phylogeny, Hepadnaviridae genetics, Hepadnaviridae classification
Abstract: Reverse-transcribing animal DNA viruses include the hepadnaviruses, a well-characterized family of small enveloped viruses that infect vertebrates but also a sister group of nonenveloped viruses more recently discovered in fish and termed the nackednaviruses. Here, we describe the complete sequence of a virus found in the feces of an insectivorous bat, which encodes a core protein and a reverse transcriptase but no envelope protein. A database search identified a viral sequence from a permafrost sample as its closest relative. The two viruses form a cluster that occupies a basal phylogenetic position relative to hepadnaviruses and nackednaviruses, with an estimated divergence time of 500 My. These findings may lead to the definition of a "proto-nackednavirus" family and support the hypothesis that the ancestors of hepadnaviruses were nonenveloped., Competing Interests: Competing interests statement:The authors declare no competing interest.
Published: 2024
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88. Targeted phage hunting to specific Klebsiella pneumoniae clinical isolates is an efficient antibiotic resistance and infection control strategy.

Author: Ferriol-González C, Concha-Eloko R, Bernabéu-Gimeno M, Fernández-Cuenca F, Cañada-García JE, García-Cobos S, Sanjuán R, and Domingo-Calap P
Subjects: Humans, Host Specificity, Infection Control methods, Anti-Bacterial Agents pharmacology, Drug Resistance, Multiple, Bacterial, Serogroup, Bacterial Capsules metabolism, Cross Infection microbiology, Klebsiella pneumoniae virology, Klebsiella Infections microbiology, Klebsiella Infections therapy, Bacteriophages physiology, Bacteriophages isolation & purification, Bacteriophages genetics, Bacteriophages classification, Phage Therapy methods
Abstract: Klebsiella pneumoniae is one of the most threatening multi-drug-resistant pathogens today, with phage therapy being a promising alternative for personalized treatments. However, the intrinsic capsule diversity in Klebsiella spp. poses a substantial barrier to the phage host range, complicating the development of broad-spectrum phage-based treatments. Here, we have isolated and genomically characterized phages capable of infecting each of the acquired 77 reference serotypes of Klebsiella spp. , including capsular types widespread among high-risk K. pneumoniae clones causing nosocomial infections. We demonstrated the possibility of isolating phages for all capsular types in the collection, revealing high capsular specificity among taxonomically related phages, in contrast to a few phages that exhibited broad-spectrum infection capabilities. To decipher the determinants of the specificity of these phages, we focused on their receptor-binding proteins, with particular attention to depolymerases. We also explored the possibility of designing a broad-spectrum phage cocktail based on phages isolated in reference capsular-type strains and determining the ability to lyse relevant clinical isolates. A combination of 12 phages capable of infecting 55% of the reference Klebsiella spp. serotypes was tested on a panel of carbapenem-resistant K. pneumoniae clinical isolates. Thirty-one percent of isolates were susceptible to the phage cocktail. However, our results suggest that in a highly variable encapsulated bacterial host, phage hunting must be directed to the specific Klebsiella isolates. This work is a step forward in the understanding of the complexity of phage-host interactions and highlights the importance of implementing precise and phage-specific strategies to treat K. pneumoniae infections worldwide.IMPORTANCEThe emergence of resistant bacteria is a serious global health problem. In the absence of effective treatments, phages are a personalized and effective therapeutic alternative. However, little is still known about phage-host interactions, which are key to implementing effective strategies. Here, we focus on the study of Klebsiella pneumoniae, a highly pathogenic encapsulated bacterium. The complexity and variability of the capsule, where in most cases phage receptors are found, make it difficult for phage-based treatments. Here, we isolated a large collection of Klebsiella phages against all the reference strains and in a cohort of clinical isolates. Our results suggest that clinical isolates represent a challenge, especially high-risk clones. Thus, we propose targeted phage hunting as an effective strategy to implement phage-derived therapies. Our results are a step forward for new phage-based strategies to control K. pneumoniae infections, highlighting the importance of understanding phage-host interactions to design personalized treatments against Klebsiella spp., Competing Interests: P.D.-C. is a co-founder of Evolving Therapeutics SL and a member of its scientific advisory board.
Published: 2024
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89. Genetic diversity and cross-species transmissibility of bat-associated picornaviruses from Spain.

Author: Carrascosa-Sàez M, Buigues J, Viñals A, Andreu-Moreno I, Martínez-Recio R, Soriano-Tordera C, Monrós JS, Cuevas JM, and Sanjuán R
Subjects: Animals, Spain, High-Throughput Nucleotide Sequencing, Metagenomics, Humans, Zoonoses virology, Zoonoses transmission, Chiroptera virology, Picornaviridae genetics, Picornaviridae classification, Picornaviridae isolation & purification, Genetic Variation, Genome, Viral, Phylogeny, Feces virology, Picornaviridae Infections transmission, Picornaviridae Infections virology, Picornaviridae Infections veterinary
Abstract: Background: Emerging zoonotic diseases arise from cross-species transmission events between wild or domesticated animals and humans, with bats being one of the major reservoirs of zoonotic viruses. Viral metagenomics has led to the discovery of many viruses, but efforts have mainly been focused on some areas of the world and on certain viral families., Methods: We set out to describe full-length genomes of new picorna-like viruses by collecting feces from hundreds of bats captured in different regions of Spain. Viral sequences were obtained by high-throughput Illumina sequencing and analyzed phylogenetically to classify them in the context of known viruses. Linear discriminant analysis (LDA) was performed to infer likely hosts based on genome composition., Results: We found five complete or nearly complete genomes belonging to the family Picornaviridae, including a new species of the subfamily Ensavirinae. LDA suggested that these were true vertebrate viruses, rather than viruses from the bat diet. Some of these viruses were related to picornaviruses previously found in other bat species from distant geographical regions. We also found a calhevirus genome that most likely belongs to a proposed new family within the order Picornavirales, and for which genome composition analysis suggested a plant host., Conclusions: Our findings describe new picorna-like viral species and variants circulating in the Iberian Peninsula, illustrate the wide geographical distribution and interspecies transmissibility of picornaviruses, and suggest new hosts for calheviruses., (© 2024. The Author(s).)
Published: 2024
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90. Full-genome sequencing of dozens of new DNA viruses found in Spanish bat feces.

Author: Buigues J, Viñals A, Martínez-Recio R, Monrós JS, Sanjuán R, and Cuevas JM
Subjects: Animals, Spain, Whole Genome Sequencing, Zoonoses virology, Feces virology, Chiroptera virology, DNA Viruses genetics, DNA Viruses classification, DNA Viruses isolation & purification, Genome, Viral, Metagenomics, Phylogeny
Abstract: Bats are natural hosts of multiple viruses, many of which have clear zoonotic potential. The search for emerging viruses has been aided by the implementation of metagenomic tools, which have also enabled the detection of unprecedented viral diversity. Currently, this search is mainly focused on RNA viruses, which are largely over-represented in databases. To compensate for this research bias, we analyzed fecal samples from 189 Spanish bats belonging to 22 different species using viral metagenomics. This allowed us to identify 52 complete or near-complete viral genomes belonging to the families Adenoviridae , Circoviridae , Genomoviridae , Papillomaviridae , Parvoviridae, Polyomaviridae and Smacoviridae . Of these, 30 could constitute new species, doubling the number of viruses currently described in Europe. These findings open the door to a more thorough analysis of bat DNA viruses and their zoonotic potential., Importance: Metagenomics has become a fundamental tool to characterize the global virosphere, allowing us not only to understand the existing viral diversity and its ecological implications but also to identify new and emerging viruses. RNA viruses have a higher zoonotic potential, but this risk is also present for some DNA virus families. In our study, we analyzed the DNA fraction of fecal samples from 22 Spanish bat species, identifying 52 complete or near-complete genomes of different viral families with zoonotic potential. This doubles the number of genomes currently described in Europe. Metagenomic data often produce partial genomes that can be difficult to analyze. Our work, however, has characterized a large number of complete genomes, thus facilitating their taxonomic classification and enabling different analyses to be carried out to evaluate their zoonotic potential. For example, recombination studies are relevant since this phenomenon could play a major role in cross-species transmission., Competing Interests: The authors declare no conflict of interest.
Published: 2024
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91. DepoScope: Accurate phage depolymerase annotation and domain delineation using large language models.

Author: Concha-Eloko R, Stock M, De Baets B, Briers Y, Sanjuán R, Domingo-Calap P, and Boeckaerts D
Subjects: Molecular Sequence Annotation, Viral Proteins genetics, Viral Proteins metabolism, Viral Proteins chemistry, Neural Networks, Computer, Machine Learning, Software, Protein Domains, Genome, Viral genetics, Carboxylic Ester Hydrolases genetics, Carboxylic Ester Hydrolases metabolism, Carboxylic Ester Hydrolases chemistry, Bacteriophages genetics, Bacteriophages enzymology, Computational Biology methods
Abstract: Bacteriophages (phages) are viruses that infect bacteria. Many of them produce specific enzymes called depolymerases to break down external polysaccharide structures. Accurate annotation and domain identification of these depolymerases are challenging due to their inherent sequence diversity. Hence, we present DepoScope, a machine learning tool that combines a fine-tuned ESM-2 model with a convolutional neural network to identify depolymerase sequences and their enzymatic domains precisely. To accomplish this, we curated a dataset from the INPHARED phage genome database, created a polysaccharide-degrading domain database, and applied sequential filters to construct a high-quality dataset, which is subsequently used to train DepoScope. Our work is the first approach that combines sequence-level predictions with amino-acid-level predictions for accurate depolymerase detection and functional domain identification. In that way, we believe that DepoScope can greatly enhance our understanding of phage-host interactions at the level of depolymerases., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Concha-Eloko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2024
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92. An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins.

Author: Marqués MC, Andreu-Moreno I, Sanjuán R, Elena SF, and Geller R
Subjects: Animals, Humans, Vesiculovirus genetics, Viral Proteins genetics, Viral Proteins immunology, HEK293 Cells, Plasmids genetics, Glycoproteins genetics, Glycoproteins immunology
Abstract: Viral glycoproteins mediate entry into host cells, thereby dictating host range and pathogenesis. In addition, they constitute the principal target of neutralizing antibody responses, making them important antigens in vaccine development. Recombinant vesicular stomatitis virus (VSV) encoding foreign glycoproteins can provide a convenient and safe surrogate system to interrogate the function, evolution, and antigenicity of viral glycoproteins from viruses that are difficult to manipulate or those requiring high biosafety level containment. However, the production of recombinant VSV can be technically challenging. In this work, we present an efficient and robust plasmid-based system for the production of recombinant VSV encoding foreign glycoproteins. We validate the system using glycoproteins from different viral families, including arenaviruses, coronaviruses, and hantaviruses, as well as highlight their utility for studying the effects of mutations on viral fitness. Overall, the methods described herein can facilitate the study of both native and recombinant VSV encoding foreign glycoproteins and can serve as the basis for the production of VSV-based vaccines., (© 2024. The Author(s).)
Published: 2024
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93. Prediction of Klebsiella phage-host specificity at the strain level.

Author: Boeckaerts D, Stock M, Ferriol-González C, Oteo-Iglesias J, Sanjuán R, Domingo-Calap P, De Baets B, and Briers Y
Subjects: Computer Simulation, Host Specificity, Bacteriophages physiology, Machine Learning, Klebsiella virology
Abstract: Phages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools do not accurately predict interactions at the strain level in a way that is relevant and properly evaluated for practical use. We present PhageHostLearn, a machine learning system that predicts strain-level interactions between receptor-binding proteins and bacterial receptors for Klebsiella phage-bacteria pairs. We evaluate this system both in silico and in the laboratory, in the clinically relevant setting of finding matching phages against bacterial strains. PhageHostLearn reaches a cross-validated ROC AUC of up to 81.8% in silico and maintains this performance in laboratory validation. Our approach provides a framework for developing and evaluating phage-host prediction methods that are useful in practice, which we believe to be a meaningful contribution to the machine-learning-guided development of phage therapeutics and diagnostics., (© 2024. The Author(s).)
Published: 2024
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94. Cell type-specific adaptation of the SARS-CoV-2 spike.

Author: Carrascosa-Sàez M, Marqués MC, Geller R, Elena SF, Rahmeh A, Dufloo J, and Sanjuán R
Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can infect various human tissues and cell types, principally via interaction with its cognate receptor angiotensin-converting enzyme-2 (ACE2). However, how the virus evolves in different cellular environments is poorly understood. Here, we used experimental evolution to study the adaptation of the SARS-CoV-2 spike to four human cell lines expressing different levels of key entry factors. After twenty passages of a spike-expressing recombinant vesicular stomatitis virus (VSV), cell-type-specific phenotypic changes were observed and sequencing allowed the identification of sixteen adaptive spike mutations. We used VSV pseudotyping to measure the entry efficiency, ACE2 affinity, spike processing, TMPRSS2 usage, and entry pathway usage of all the mutants, alone or in combination. The fusogenicity of the mutant spikes was assessed with a cell-cell fusion assay. Finally, mutant recombinant VSVs were used to measure the fitness advantage associated with selected mutations. We found that the effects of these mutations varied across cell types, both in terms of viral entry and replicative fitness. Interestingly, two spike mutations (L48S and A372T) that emerged in cells expressing low ACE2 levels increased receptor affinity, syncytia induction, and entry efficiency under low-ACE2 conditions. Our results demonstrate specific adaptation of the SARS-CoV-2 spike to different cell types and have implications for understanding SARS-CoV-2 tissue tropism and evolution., Competing Interests: None declared., (© The Author(s) 2024. Published by Oxford University Press.)
Published: 2024
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95. Temperature impacts SARS-CoV-2 spike fusogenicity and evolution.

Author: Dufloo J and Sanjuán R
Subjects: Humans, Temperature, Furin, Cold Temperature, Spike Glycoprotein, Coronavirus genetics, SARS-CoV-2 genetics, COVID-19
Abstract: SARS-CoV-2 infects both the upper and lower respiratory tracts, which are characterized by different temperatures (33°C and 37°C, respectively). In addition, fever is a common COVID-19 symptom. SARS-CoV-2 has been shown to replicate more efficiently at low temperatures, but the effect of temperature on different viral proteins remains poorly understood. Here, we investigate how temperature affects the SARS-CoV-2 spike function and evolution. We first observed that increasing temperature from 33°C to 37°C or 39°C increased spike-mediated cell-cell fusion. We then experimentally evolved a recombinant vesicular stomatitis virus expressing the SARS-CoV-2 spike at these different temperatures. We found that spike-mediated cell-cell fusion was maintained during evolution at 39°C but was lost in a high proportion of viruses that evolved at 33°C or 37°C. Consistently, sequencing of the spikes evolved at 33°C or 37°C revealed the accumulation of mutations around the furin cleavage site, a region that determines cell-cell fusion, whereas this did not occur in spikes evolved at 39°C. Finally, using site-directed mutagenesis, we found that disruption of the furin cleavage site had a temperature-dependent effect on spike-induced cell-cell fusion and viral fitness. Our results suggest that variations in body temperature may affect the activity and diversification of the SARS-CoV-2 spike., Importance: When it infects humans, SARS-CoV-2 is exposed to different temperatures (e.g., replication site and fever). Temperature has been shown to strongly impact SARS-CoV-2 replication, but how it affects the activity and evolution of the spike protein remains poorly understood. Here, we first show that high temperatures increase the SARS-CoV-2 spike fusogenicity. Then, we demonstrate that the evolution of the spike activity and variants depends on temperature. Finally, we show that the functional effect of specific spike mutations is temperature-dependent. Overall, our results suggest that temperature may be a factor influencing the activity and adaptation of the SARS-CoV-2 spike in vivo , which will help understanding viral tropism, pathogenesis, and evolution., Competing Interests: The authors declare no conflict of interest.
Published: 2024
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96. Cellular receptors for mammalian viruses.

Author: Valero-Rello A, Baeza-Delgado C, Andreu-Moreno I, and Sanjuán R
Subjects: Animals, Receptors, Virus, Membrane Proteins, Machine Learning, Mammals, Receptors, Cell Surface, Viruses
Abstract: The interaction of viral surface components with cellular receptors and other entry factors determines key features of viral infection such as host range, tropism and virulence. Despite intensive research, our understanding of these interactions remains limited. Here, we report a systematic analysis of published work on mammalian virus receptors and attachment factors. We build a dataset twice the size of those available to date and specify the role of each factor in virus entry. We identify cellular proteins that are preferentially used as virus receptors, which tend to be plasma membrane proteins with a high propensity to interact with other proteins. Using machine learning, we assign cell surface proteins a score that predicts their ability to function as virus receptors. Our results also reveal common patterns of receptor usage among viruses and suggest that enveloped viruses tend to use a broader repertoire of alternative receptors than non-enveloped viruses, a feature that might confer them with higher interspecies transmissibility., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Valero-Rello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Published: 2024
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97. Optimized Recovery of Viral DNA and RNA from Blood Plasma for Viral Metagenomics.

Author: Cebriá-Mendoza M, Díaz W, Sanjuán R, and Cuevas JM
Subjects: Humans, Ecosystem, RNA, Viral genetics, Metagenomics methods, Plasma, Genome, Viral, High-Throughput Nucleotide Sequencing methods, DNA, Viral genetics, Viruses genetics
Abstract: Metagenomics is vastly improving our ability to discover new viruses, as well as their possible associations with disease. However, metagenomics has also changed our understanding of viruses in general. This is because we can find viruses in healthy hosts in the absence of disease, which changes the perspective of viruses as mere pathogens and offers a new perspective in which viruses function as important components of ecosystems. In concrete, human blood metagenomics has revealed the presence of different types of viruses in apparently healthy subjects. These viruses are human anelloviruses and, to a lower extent, human pegiviruses. Viral metagenomics' major challenge is the correct isolation of the viral nucleic acids from a specific sample. For the protocol to be successful, all steps must be carefully chosen, in particular those that optimize the recovery of viral nucleic acids. Here, we present a procedure that allows the recovery of both DNA and RNA viruses from plasma samples., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Published: 2024
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98. Broad-range capsule-dependent lytic Sugarlandvirus against Klebsiella sp.

Author: Concha-Eloko R, Barberán-Martínez P, Sanjuán R, and Domingo-Calap P
Subjects: Humans, Klebsiella, Klebsiella pneumoniae, Bacteriophages, Klebsiella Infections microbiology
Abstract: Importance: The emergence of multi-drug resistant bacteria is a global health problem. Among them, Klebsiella pneumoniae is considered a high-priority pathogen, making it necessary to develop new therapeutic tools to reduce the bacterial burden in an effective and sustainable manner. Phages, bacterial viruses, are very promising tools. However, phages are highy specific, rendering large-scale therapeutics costly to implement. This is especially certain in Klebsiella , a capsular bacterium in which phages have been shown to be capsular type dependent, infecting one or a few capsular types through specific enzymes called depolymerases. In this study, we have isolated and characterized novel phages with lytic ability against bacteria from a wide variety of capsular types, representing the Klebsiella phages with the widest range of infection described. Remarkably, these broad-range phages showed capsule dependency, despite the absence of depolymerases in their genomes, implying that infectivity could be governed by alternative mechanisms yet to be uncovered., Competing Interests: The authors declare no conflict of interest.
Published: 2023
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99. Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity.

Author: Cebriá-Mendoza M, Beamud B, Andreu-Moreno I, Arbona C, Larrea L, Díaz W, Sanjuán R, and Cuevas JM
Subjects: Male, Humans, Female, Demography, Recombination, Genetic, DNA, Viral, Anelloviridae genetics, DNA Virus Infections epidemiology, Torque teno virus genetics
Abstract: Anelloviruses represent the major and most diverse component of the healthy human virome, referred to as the anellome. In this study, we determined the anellome of 50 blood donors, forming two sex- and age-matched groups. Anelloviruses were detected in 86% of the donors. The number of detected anelloviruses increased with age and was approximately twice as high in men as in women. A total of 349 complete or nearly complete genomes were classified as belonging to torque teno virus (TTV), torque teno mini virus (TTMV), and torque teno midi virus (TTMDV) anellovirus genera (197, 88, and 64 sequences, respectively). Most donors had intergenus (69.8%) or intragenus (72.1%) coinfections. Despite the limited number of sequences, intradonor recombination analysis showed 6 intragenus recombination events in ORF1. As thousands of anellovirus sequences have been described recently, we finally analyzed the global diversity of human anelloviruses. Species richness and diversity were close to saturation in each anellovirus genus. Recombination was found to be the main factor promoting diversity, although its effect was significantly lower in TTV than in TTMV and TTMDV. Overall, our results suggest that differences in diversity between genera may be caused by variations in the relative contribution of recombination. IMPORTANCE Anelloviruses are the most common human infectious viruses and are considered essentially harmless. Compared to other human viruses, they are characterized by enormous diversity, and recombination is suggested to play an important role in their diversification and evolution. Here, by analyzing the composition of the plasma anellome of 50 blood donors, we find that recombination is also a determinant of viral evolution at the intradonor level. On a larger scale, analysis of anellovirus sequences currently available in databases shows that their diversity is close to saturation and differs among the three human anellovirus genera and that recombination is the main factor explaining this intergenus variability. Global characterization of anellovirus diversity could provide clues about possible associations between certain virus variants and pathologies, as well as facilitate the implementation of unbiased PCR-based detection protocols, which may be relevant for using anelloviruses as endogenous markers of immune status., Competing Interests: The authors declare no conflict of interest.
Published: 2023
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100. Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies.

Author: Planas D, Bruel T, Staropoli I, Guivel-Benhassine F, Porrot F, Maes P, Grzelak L, Prot M, Mougari S, Planchais C, Puech J, Saliba M, Sahraoui R, Fémy F, Morel N, Dufloo J, Sanjuán R, Mouquet H, André E, Hocqueloux L, Simon-Loriere E, Veyer D, Prazuck T, Péré H, and Schwartz O
Subjects: Humans, Antibodies, Viral, Antiviral Agents, Breakthrough Infections, Spike Glycoprotein, Coronavirus genetics, Antibodies, Neutralizing, BNT162 Vaccine, COVID-19 immunology, COVID-19 prevention & control, SARS-CoV-2 genetics
Abstract: Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. The subvariant BQ.1.1 became predominant in many countries in December 2022. The subvariants carry an additional and often redundant set of mutations in the spike, likely responsible for increased transmissibility and immune evasion. Here, we established a viral amplification procedure to easily isolate Omicron strains. We examined their sensitivity to 6 therapeutic monoclonal antibodies (mAbs) and to 72 sera from Pfizer BNT162b2-vaccinated individuals, with or without BA.1/BA.2 or BA.5 breakthrough infection. Ronapreve (Casirivimab and Imdevimab) and Evusheld (Cilgavimab and Tixagevimab) lose antiviral efficacy against BA.2.75.2 and BQ.1.1, whereas Xevudy (Sotrovimab) remaine weakly active. BQ.1.1 is also resistant to Bebtelovimab. Neutralizing titers in triply vaccinated individuals are low to undetectable against BQ.1.1 and BA.2.75.2, 4 months after boosting. A BA.1/BA.2 breakthrough infection increases these titers, which remains about 18-fold lower against BA.2.75.2 and BQ.1.1, than against BA.1. Reciprocally, a BA.5 breakthrough infection increases more efficiently neutralization against BA.5 and BQ.1.1 than against BA.2.75.2. Thus, the evolution trajectory of novel Omicron subvariants facilitates their spread in immunized populations and raises concerns about the efficacy of most available mAbs., (© 2023. The Author(s).)
Published: 2023
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