77 results on '"Sanjay Das"'
Search Results
52. Lipid
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Sangita Santra and Sanjay Das
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- 2019
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53. Variation in Cost Among Anticancer Drugs Available in India: A Cross-sectional Study
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Ramanand Janardhanrao Patil, Prasan Ramchandra Bhandari, Sanjay Dashrath Gaiwale, Vivek Jawahar Dugad, and Santosh Baburao Jagtap
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cancer ,ceiling price ,cost analysis ,cost variation ,pharmacoeconomic ,Medicine - Abstract
Introduction: Cancer is an abnormal growth of cells, and it encompasses over 100 types of cancers that affect humans. Cancer management often involves a combination of radiation therapy, surgery, chemotherapy, and targeted therapy. Anticancer drugs, in general, tend to be more expensive compared to other categories of drugs, significantly contributing to the overall drug expenditure incurred by patients. Aim: To analyse the percentage variation in cost among different brands of anticancer drugs available in the Indian market. Materials and Methods: A cross-sectional study was conducted in the Department of Pharmacology at Symbiosis Medical College, Symbiosis International University, in Pune, Maharashtra, India. The study duration was six months, from March 2021 to August 2021. Data on the prices of anticancer drugs were collected and analysed using the October 2020 to January 2021 edition of the Current Index of Medical Specialities (CIMS). A total of 29 anticancer drugs with different strengths were considered. The cost of a particular anticancer drug with the same dose and dosage form produced by different companies was compared. Drugs were selected based on their strength and dosage forms. The cost of one tablet, capsule, or injection was calculated in Indian Rupees (INR). The cost of a single unit was compared, and the difference between the maximum and minimum costs was calculated. Subsequently, cost ratios and the percentage of cost variation were determined. The study findings were recorded in both Microsoft Word 2016 and Excel 2016, and they were expressed as absolute numbers and percentages. Results: Bortezomib 3.5 mg was the costliest among anticancer drug which was priced at INR 18,988.00, while the cheapest was methotrexate 2.5 mg tablet, priced at INR 1.886. Among the anticancer drugs, pacilitaxel 260 mg injection had the highest cost ratio of 1 29.3055, whereas cisplatin 10 mg injection had the lowest cost ratio 1. Regarding cost variation, pacilitaxel 260 mg injection showed the highest percentage of cost variation at 2830.5555%, while cisplatin 10 mg injection showed the lowest at 0%. Conclusion: This study revealed a significant variation in prices, cost ratios, and cost variation among different anticancer drugs, providing insights into the price discrepancies observed in the market. The findings can help physicians and policymakers become aware of the cost variations among these drugs and make informed decisions regarding pricing.
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- 2023
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54. Neotectonic Activities in Northern Saurashtra Peninsula Bordering Gulf of Kachchh
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Sanjay Das, Swapnil Chaudhari, and Poonam Singh
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geography ,Saurashtra ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Geography, Planning and Development ,Drainage basin ,Active fault ,010502 geochemistry & geophysics ,Strike-slip tectonics ,01 natural sciences ,Neotectonics ,Sinistral and dextral ,Earth and Planetary Sciences (miscellaneous) ,Relief ratio ,Geomorphology ,Drainage density ,Geology ,0105 earth and related environmental sciences - Abstract
This study points out the evidences of neotectonics and possible existence of active fault in northern part of Saurashtra Peninsula. The methodology used for the detection of neotectonism are: a) analysis of numerical data obtained from Digital Elevation Model (DEM) and its derivatives (morphometric indices), b) study of geomorphic markers and c) correlation of seismic & palaeoseismic data and geomorphology with structural lineaments. Morphometric indices such as drainage density, stream frequency, bifurcation ratio, basin length, basin relief, relief ratio, elongation ratio, stream gradient index, hypsometric index and sinuosity ratio have been used to assess the tectonic signatures. Morphometric indices suggest that Aji river basin is tectonically active, whereas Und and Sasoi river basins show some of the parameters in active tectonic range. Regional study using remotely sensed data (Landsat OLI multispectral) has helped to show a) about 100° dextral rotation of Aji river trunk channel near the Gulf coast and b) dextral deflection of both Aji and Und river about 25 km from the coast. Study of a segment of Aji river basin near Ranjitpura- Balamba proved upliftment and tilting of land resulting a) narrowing of trunk channel towards sea, b) development of new sets of channels over tilted river terrace, c) development of beheaded channels, d) presence of palaeo-channels and palaeo-delta in different directions with the present ones and e) formation of estuary with definite geometric shape. Occurrence of earthquake epicentres, in conformity with predicted lineaments in addition to paleoseismic records supports the existence of the fault. On the basis of integrated evidences it has been established that the Saurashtra coast along the Gulf of Kachchh is tectonically active with the existence of a dextral strike slip fault (ENE-WSW trending) with a rotational component manifesting tilting of the northern block towards east.
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- 2016
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55. Hardware realisation of an intelligent medical image watermarking
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Sandeep Bal, Sanjay Das, Debamita Biswas, Abhishek Basu, Soumadeb Dutta, and Souma Das
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Pixel ,Computer science ,business.industry ,Realisation ,Mechanical Engineering ,Schematic ,Binary number ,Watermark ,Condensed Matter Physics ,Embedding ,Computer vision ,General Materials Science ,Artificial intelligence ,Field-programmable gate array ,business ,Digital watermarking - Abstract
Digital intelligence features the competence to transmit data at a swifter measure with a substantially superior computing relaxation. Hindrance to this is the up rise of copyright transgression problems. In digital watermarking, novel consumer embeds a distinguishable imprint in the digital medium for eschewing franchise breach. A tunnelled version of the aforementioned methodology is medical image watermarking which primarily focuses on embedding of the watermark in a concerned medical pictorial. The writers have concerned on the realm of intelligent medical image watermarking. Medicative images like USG, CT scan, MRI and X-rays are utilised. An inkling of shovelling a masked image in juxtaposition to the novel medical paradigm has been insinuated. The binary mask used is primarily sectioned according to a fixed ratio and in accordance with a predefined intelligent schematic, the watermark bits are hidden in only a part of the sections to prevent distortion of the information pixels in the medical image. The entrenchment and excerpting epistemologies have been operationalised utilising FPGA. The image testing parameter outcomes are discernibly persistent. Furthermore, an analogy of the proposed approach against few germane methods ensures the supremacy of the technique put forward.
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- 2020
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56. FPGA Realization of Medical Image Watermarking
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Abhishek Basu, Sandeep Bal, Sanjay Das, Debamita Biswas, Souma Das, and Soumadeb Dutta
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Least significant bit ,Pixel ,business.industry ,Computer science ,Copyright infringement ,Cryptography ,Computer vision ,Watermark ,Artificial intelligence ,business ,Encryption ,Digital watermarking ,Digital media - Abstract
Digital information, being discrete in nature, possesses the capability to transfer more information at a faster rate with a significantly higher processing ease, all of which are in sharp contrast to analogue information. This has led to digital information being at the forefront of different types of media like image, video and audio. The only drawback of this has been the rise of copyright infringement issues, whereby the original owner becomes devoid of his claim over his uniquely designed creation because of duplicity and tampering by malicious users. Digital watermarking is a well sought out solution to this. The original user deliberately implants a distinctively identifiable impression onto the digital media for preventing copyright violation. The authors over here have focused on the specific domain of Medical Image Watermarking. Medical images like X-rays, USG, and MRI have revolutionized the medication fraternity by providing enhanced diagnosis and treatment of patients. But at the same time, copyright infringement of the medical images is a growing concern. To curb this problem, a notion of creating a binary masked image in comparison to the original medical image has been suggested. The mask helps in specifically identifying the region of interest (ROI)wherein the encrypted watermark has to be implanted for better imperceptibility and security. The encrypted watermark is embedded in the spatial domain, that is, the Least Significant Bit (LSB)of image pixels are modified in accordance to the watermarking bits. For a widespread acceptance of the proposed technique, the embedding and extracting methodologies have been implemented using Field Programmable Gate Array (FPGA). The imperceptibility, security and bit hiding capacity results are appreciably substantial. Further, a comparison of the suggested technique against some already relevant cutting edge techniques guarantees the superiority of the proposed technique.
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- 2018
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57. Complications of percutaneous nephrostomy in a district general hospital
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Ninaad Awsare, Gerard Doyle, Sanjay Das, James Broome, Seth Horsu, Dev Mohan Gulur, Rafal Turo, and Bo Adrian Pettersson
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medicine.medical_specialty ,Blood transfusion ,medicine.diagnostic_test ,business.industry ,Septic shock ,medicine.medical_treatment ,medicine.disease ,Surgery ,Sepsis ,Pneumonia ,Catheter ,Percutaneous nephrostomy ,Medicine ,Blood culture ,business ,Complication ,Endourology - Abstract
OBJECTIVE Percutaneous nephrostomy (PCN) is one of the commonest procedures performed. There are currently no European recommendations on the accepted rate of complications. The aim of the present study is to report the complication rate of PCN with the specific emphasis on sepsis and septic shock, the causative organisms, sensitivities to antibiotics, and associated risk factors. MATERIAL AND METHODS Retrospectively collected data on patients undergoing acute or elective PCN at the Department of Radiology, Countess of Chester Hospital (COCH), in the UK between January 2014 and December 2016 were analyzed after the study was approved by Local Audit Department at COCH. RESULTS A total of 66 patients underwent 90 acute or elective PCNs. Three patients developed major post-PCN complication (two patients developed septic shock and the third suffered a hemorrhagic episode requiring blood transfusion). Nephrostomy tube complications (blockage, leaking, fracturing and kinking of the catheter) occurred in 4 patients. Complications were more common when the PCN was performed out of working hours (71.4% [10/14], and 17.3% [9/52] for PCNs performed within, and out of working hours, respectively: p
- Published
- 2018
58. Is magnetic resonance imaging helpful in detecting significant prostate cancer in patients with haematospermia, normal PSA and DRE. A single institution, observational, and retrospective study in a United Kingdom hospital
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Michal Smolski, Bo Adrian Pettersson, Dev Mohan Gulur, Gerard Doyle, Ninaad Awsare, Helene Thygesen, Andra Calinciuc, Sanjay Das, Rafal Turo, and Seth Horsu
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medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,030232 urology & nephrology ,Retrospective cohort study ,Magnetic resonance imaging ,General Medicine ,Rectal examination ,Odds ratio ,urologic and male genital diseases ,medicine.disease ,03 medical and health sciences ,Prostate-specific antigen ,Prostate cancer ,0302 clinical medicine ,medicine.anatomical_structure ,Haematospermia ,Prostate ,medicine ,Radiology ,medicine.symptom ,business - Abstract
Introduction Haematospermia is an uncommon clinical condition that may be associated with prostate cancer. The optimal investigation of haematospermia is unknown. The aim of this study was to investigate haematospermia as a presenting symptom of significant pathology and to assess the diagnostic value of magnetic resonance imaging (MRI). Material and methods Patient and treatment parameters were collected from a practice cohort of men referred to a urology center presenting with haematospermia. We used a multivariate logistic regression model to test the independent significance of MRI in detecting prostate cancer (PCa) after adjusting for other known predictors of PCa detection. Results A total of 125 men (median age 58 years) were evaluated between 2012-2015. In the univariate and multivariate logistic regression model MRI was a significant predictor of PCa diagnosis after adjusting for age, prostate specific antigen (PSA) and digital rectal examination (DRE) results (Odds Ratio (OR) 14.15, p = 0.001). Of 107 patients who underwent MRI prostate imaging, 31 (28.9%) had reports suspicious of PCa. In 26 patients, other benign conditions were detected on MRI. PCa was detected in 12 (25.5%) of the 47 men (median age 61 years; range 43 to 85) who underwent prostate biopsies. Eight (17%) of these patients had Gleason ≥7 grade cancer. The persistence of haematospermia was not an independent predictor of cancer diagnosis (OR 0.20, p = 0.15). Conclusions PCa is not commonly associated with haematospermia. MRI seems to be improving detection rate of a significant PCa, particularly in patients presenting with haematospermia and normal PSA levels and DRE examination. Duration of haematospermia does not predict the presence of PCa.
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- 2018
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59. Parameterless Harmony Search for Image Multi-thresholding
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Krishna Gopal Dhal, Sanjay Das, and Iztok Fister
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business.industry ,Computer science ,Harmony search ,Pattern recognition ,Artificial intelligence ,business ,Thresholding ,Image (mathematics) - Published
- 2017
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60. Stakeholders’ Perception on Self Help Group’s Quality Parameters: A Psychometrics Analysis
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Sanjay Das
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Self-help ,Psychometrics ,Descriptive statistics ,Feeling ,Kruskal–Wallis one-way analysis of variance ,Corporate governance ,media_common.quotation_subject ,Meta-analysis ,Applied psychology ,General Medicine ,Psychology ,DRDA ,media_common - Abstract
Aims: The main objective of this paper is to assess the opinion of the direct stakeholders (i.e. Promoters, Donors, Financial Institutions and Group itself) of SHGs regarding the parameters (like design, governance, operational, impact etc.) to be considered while assessing the quality of SHGs. Study Design: The study was exploratory in nature with Meta Analysis as well as Psychometric Approach based on empiricism. Place and Duration of Study: The present study covers all the direct Stakeholders of SHGs of Nagaon districts of Assam, India only. Information through questionnaires were collected during first half of 2012 i.e. from March, 2012 to July, 2012. Methodology: The information about the number of SHGs in respective development blocks and number of other stakeholders were obtained from the Office of DRDA, Nagaon, Assam, India. With multi-stage random sampling method, initially after collection of 116 filled up questionnaires from the respondents, editing of the data was undertaken in order to ensure the omission, completeness and consistency of the data. Finally, 100 questionnaires consisting 44 SHG group members, 12 Financial, 10 Donors and 34 promoters were selected. The questionnaire was personally administered to all direct Original Research Article British Journal of Economics, Management & Trade, 4(4): 487-522, 2014 488 stakeholders except Group members. Some questionnaires were collected directly by the researcher on face-to-face method and some of them were collected by arranging meetings at village level. In order to gain an in-depth understanding on the research topic specially structured questionnaires were prepared and were later judged by groups of content judges and finally it was pilot tested. Further, the data collected through the questionnaires were analysed through measures of descriptive statistics like mean, median and standard deviation. Chronbach’s alpha, one sample KolmogorovSmirnov Test, Shapiro-Wilk Test, Kruskal Wallis Test and Eta Squared Test were also applied in analysing and interpreting the data. Results: It was observed from KW Test that there exists enough evidence to conclude that there is a no difference among the opinion of the direct stakeholders of SHGs regarding the parameters to be considered while assessing the quality of SHGs. Further, to investigate the degree of association, Eta Squared test was conducted and it indicates low a level of association. Conclusion: It can be discerned that Groups of QAP-I covering feeling of homogeneity/ solidarity, member awareness about financial, transactions involvement in village issues etc. are the statements where there are no differences of opinion amongst the stakeholders while Groups of QAP-II where differences of opinion exists amongst the stakeholders exists and are considered more decisive statements or factors influencing the quality assessment parameters of SHG under given methodology which was also virtually supported by other researchers. Further, the present study also satisfies the two models of generalisability i.e. Statistical generalisation and transferability or reader generalisability.
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- 2014
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61. Structural alterations in compound eye ofDrosophila melanogasterin response to sodium fluoride treatment
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Moumita Dutta, Sanjay Das, and Sumedha Roy
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biology ,Health, Toxicology and Mutagenesis ,Anatomy ,Compound eye ,Bristle ,biology.organism_classification ,Pollution ,Cell biology ,chemistry.chemical_compound ,chemistry ,Ommatidium ,Sodium fluoride ,Environmental Chemistry ,Drosophila melanogaster ,Fluoride ,Drosophila ,Function (biology) - Abstract
Sodium fluoride, used as a pesticide in agriculture, is also an ingredient of toothpastes which help to fight dental problems. In this study, Drosophila melanogaster, a non-target organism, is used to explore morphological changes in the adult compound eye as a function of exposure to fluoride at 20, 40, 80, 100 and 150 mg L−1, using scanning electron microscopy. The experimental concentrations were much lower than the ones used in the studies of the British Association of Community Dentistry. Distinct morphological alterations in the eye of the treated insects revealed ommatidial ridges and disoriented mechanosensory bristles which were most prominent in the 40 and 80 mg L−1 treatment groups. Since humans and Drosophila share homology in many genes that are involved in developmental pathways, the present findings raise concern on the use of sodium fluoride as a pesticide.
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- 2014
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62. Inspection of Ureteral Orifices: The Pearl of Flexible Cystoscopy
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Seshikanth Middela, Hamid Bushra, Bo Pettersson, Sanjay Das, and Charmaine Matthews
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Case Report ,Flexible cystoscopy ,Cystoscopy ,Surgery ,Imaging modalities ,Ureter ,medicine.anatomical_structure ,Rare case ,medicine ,Examination technique ,Radiology ,business - Abstract
Cystoscopy is most common diagnostic investigation. The examination technique and the findings, both normal and pathological, were well described described a hundred years ago. With technological advances, there has been over-emphasis on imaging modalities for diagnostic purposes. A basic maneuver of examining the ureteral orifices is sometimes rushed through when in fact careful examination can clinch the diagnosis. The importance is exemplified by two cases, one of which is a rare case of Xanthoma of the ureter.
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- 2015
63. MP08-06 DISTRACTIONS IN THE OPERATING THEATRE. ARE WE TOO LOUD?
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Rafal Turo, Bo Pettersson, Dev Mohan Gulur, Sanjay Das, Michal Smolski, and Ninaad Awsare
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business.industry ,Urology ,Medicine ,business ,Visual arts - Published
- 2016
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64. Petrogenesis of lamprophyres from Chhota Udepur area, Narmada rift zone, and its relation to Deccan magmatism
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Sanjay Das, N. V. Chalapathi Rao, and C.V. Dharma Rao
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Perthite ,Large igneous province ,Geochemistry ,Partial melting ,Geology ,engineering.material ,Augite ,engineering ,Phenocryst ,Kaersutite ,Petrology ,Amphibole ,Earth-Surface Processes ,Petrogenesis - Abstract
Geological setting, petrology and geochemistry of a new find of lamprophyre dykes, intruding the Precambrian basement gneisses from the Chhota Udepur area, Narmada rift zone, Western India, are presented. Of the three lamprophyre dykes, two of them display E–W trend paralleling that of the Narmada rift, extend up to ∼2.5 km in length and constitute the longest yet recorded lamprophyre dykes from the Indian shield. The Chhota Udepur lamprophyres (CUL) show several overlapping mineralogical and geochemical characteristic features displayed by alkaline- and calc-alkaline lamprophyres and hence it is not straight forward to pigeon-hole them in existing lamprophyre classification schemes. They are porphyritic–panidiomorphic with euhedral to sub-hedral phenocrysts and microphenocrysts of olivine (Fo78.33–78.42 Fa21.24–21.37), diopsidic augite to titaniferous augite (Wo54.83–59.03 En36.75–41.36 Fs0.1–5.66), biotite and amphibole (kaersutite). Feldspar (orthoclase perthite and plagioclase) is essentially confined to the groundmass along with accessory phases such as apatite and spinel (ti-magnetite). Rare carbonate ocelli are also present. In terms of major element geochemistry the CUL are nepeheline-normative and predominantly sodic (Na2O > K2O); yet their K2O and SiO2 contents are sufficiently high to signal traits of calc-alkaline lamprophyres. On the other hand, the CUL exclude negative spikes at Nb–Ta which are considered to be a characteristic of subduction-related (calc-alkaline) magmas, are highly evolved (Mg#: 27.82–55.45), enriched in incompatible trace elements (high La/Nb, Zr/Nb) and have fractionated REE distribution patterns (La/YbN ratios: 35–44). Post-emplacement alteration and crustal contamination have had little influence on their geochemistry. Th/Yb, Ta/Yb, Nb/U and Ce/Pb ratios of the CUL imply an OIB type-enriched mantle source, similar to that displayed by other Deccan-related lamprophyres. A metasomatised (enriched) garnet lherzolite mantle source with very low degrees of partial melting that has subsequently undergone a large degrees of fractional crystallisation is capable of accounting observed REE geochemistry of the CUL. We infer the lamprophyres of Chhota Udepur area to be a part of the alkaline rock spectrum of the Deccan Large Igneous Province and their emplacement, together with that of other alkaline complexes in the Chhota Udepur area, is envisaged to be strongly controlled by pre-existing crustal weakness accentuated by the mantle plume–lithosphere interaction during the end-Cretaceous in the Narmada rift zone.
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- 2012
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65. Identification of Loriya Fault, Its Reactivation Due to 2001 Bhuj Earthquake, (Using Remote Sensing Data) and Its Bearing on the Kachchh Mainland Fault, Kachchh District, Gujarat
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Sanjay Das, Pramod Kumar Singh, and S. R. Mohapatra
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geography ,geography.geographical_feature_category ,Lineament ,Geography, Planning and Development ,Alluvial fan ,Slip (materials science) ,Active fault ,Fault scarp ,Strike-slip tectonics ,Earth and Planetary Sciences (miscellaneous) ,Satellite imagery ,Digital imagery ,Geology ,Seismology - Abstract
The 2001 Bhuj earthquake (Mw 7.7), one of the most severe earthquakes in the recent history of India, reactivated various existing active faults. It is manifested in the form of coseismic ground fissures/cracks and upheaval of land in the form of bumps. Identification and reactivation of Loriya Fault is established by 1—Geomorphic changes with the help of digital imagery (LISS III images). 2—Coseismic changes through ground checks and 3—Geophysical signatures through magnetic and gravity survey. A lineament cutting the north-western part of the Pur River alluvial fan has been revealed by satellite imagery. The streams flowing along the lineament add to the evidences of a weak plane, while the occurrence of coseismic ground fissures confirms the existence of an active fault. No dip slip movement is recorded in the trenches made across the Loriya active fault while the en-echelon pattern of ground fissures suggest strike slip movement along the fault due to 2001 earthquake.
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- 2011
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66. Major tea processing practices in India
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Bhaskar Chakraborty, Satyajit Sarkar, Monoranjan Chowdhury, Sanjay Das, Palash Mandal, and Anurag Chowdhury
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Traditional medicine ,010308 nuclear & particles physics ,Manufacturing process ,05 social sciences ,food and beverages ,050109 social psychology ,Green tea ,complex mixtures ,01 natural sciences ,Agricultural economics ,Geography ,0103 physical sciences ,0501 psychology and cognitive sciences ,West bengal ,Sri lanka ,China - Abstract
Tea is world’s most popular beverages and is the economical backbones of various tea producing countries like India, China, Sri Lanka, Kenya etc. Indian tea is very much famous in the world, especially Darjeeling tea which is famous for its unique flavour and taste. Among the various types of tea, Orthodox tea is highly demandable among the various types of tea due to its quality. Present article focused on different types of major tea processing in India. In India, mostly three types of tea processing are practices, among them, CTC tea processing is more common followed by Green tea and Orthodox tea. In this paper, step wise details manufacturing process are presented. All the data are extracted during the extensive survey in different world famous tea gardens of Darjeeling hills, terai and duars of Northern West Bengal.
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- 2016
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67. Localized traumatic infarction of the testicle
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Sanjay Das, John McCabe, Christopher S. Powell, and Bushra Hamid
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Urology ,Testicular Neoplasm ,Infarction ,Testicular infarct ,Testicle ,Wounds, Nonpenetrating ,Severity of Illness Index ,Testicular Diseases ,Diagnosis, Differential ,Testicular Neoplasms ,Internal medicine ,Testis ,medicine ,Neoplasm ,Humans ,cardiovascular diseases ,business.industry ,Ultrasonography, Doppler ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,cardiovascular system ,Radiology ,business ,Orchiectomy ,Follow-Up Studies - Abstract
Ultrasonically it is extremely difficult to accurately distinguish testicular infarct from neoplasm. We describe a case which highlights this, together with the previously unreported phenomenon of a localized infarct secondary to trauma.
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- 2005
68. Key factors in road-rail mode choice in India: applying the logistics cost approach
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Peter D. Cook, Carl D. Martland, Sanjay Das, and Andreas Aeppli
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Transport engineering ,education.field_of_study ,Key factors ,Economic indicator ,Agriculture ,business.industry ,Rail transportation ,Population ,Rail traffic ,Cost approach ,Business ,Mode choice ,education - Abstract
There have been major changes in the share of road and rail traffic in India as the economy and the population has grown and become more urbanized. This paper summarizes the key factors for mode choice in freight transport that were found in India in a recent survey based on the logistics cost model of shipper behavior. Both the relative importance of these factors and customer rating of satisfaction is presented.
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- 2003
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69. Quality Parameters Of Self Help Group's: A Review
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Sanjay Das, A. Ibemcha Chanu, Sanjay Das, and A. Ibemcha Chanu
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- 2013
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70. The changing face of pregnancy-related acute kidney injury from eastern part of India: A hospital-based, prospective, observational study
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Sandeep Saini, Arpita Ray Chaudhury, Smita Divyaveer, Pratima Maurya, Dipankar Sircar, Sanjay Dasgupta, Debabrata Sen, Sambhunath Bandyopadhyay, and Rajendra Pandey
- Subjects
Medicine - Abstract
This study was initiated to look into the etiologies, prevalence, and outcome of pregnancy-related acute kidney injury (PRAKI) in a tertiary care hospital. Women admitted with PRAKI from January 2015 to December 2016 were included in the study. All patients were investigated and treated and followed up for the next six months.. For statistical analysis, Chi- square test and analysis of variance were performed to analyze the data. Multivariate analysis was applied to compare the risk of nonrecovery of renal function in different etiologies of PRAKI. During the study period, 81 patients were admitted with PRAKI, of whom 68 (84%) received hemodialysis (HD). A total of 449 patients including all cases of AKI underwent HD from January 2015 to June 2016. The incidence of dialysis requiring PRAKI was 68 out of the 449 patients (15%). Sixty-eight (84%) patients required dialysis support while the most common cause was sepsis (49%), with the second being pregnancy-associated atypical hemolytic-uremic syndrome (P-aHUS) (17%) followed by obstetric hemorrhages (16%). There was a significant reduction of first-trimester AKI (8.6%) compared to a previous study published from this institute (19.3%). The maternal mortality (25%) and fetal mortality (23.5%) were high. Nearly 39% of the patients had complete recovery of renal function. This study revealed significant PRAKI burden due to a largely preventable cause, puerperal sepsis. Renal survival was poor in P- aHUS. The gaps in the obstetric care may be identified for the improvement of fetomaternal outcome.
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- 2020
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71. An unusual case of chronic urinary retention and bladder diverticulum presenting with unilateral lower limb swelling
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Bo Pettersson, Dev Gulur, Sanjay Das, and James Edward Dyer
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Male ,medicine.medical_specialty ,Urinary system ,Urinary Bladder ,Urology ,Urinary Catheters ,Article ,Lower urinary tract symptoms ,medicine ,Edema ,Humans ,Renal Insufficiency ,Abscess ,Hydronephrosis ,Bladder diverticulum ,Leg ,Urinary bladder ,Urinary retention ,business.industry ,General Medicine ,Middle Aged ,Urinary Retention ,medicine.disease ,Surgery ,Diverticulum ,Neck of urinary bladder ,medicine.anatomical_structure ,Hyperkalemia ,medicine.symptom ,business - Abstract
A 64-year-old man presented with 1 month of gradual-onset left leg swelling and lower urinary tract symptoms including enuresis, frequency and poor stream. He was initially treated for suspected cellulitis, however, he returned 2 weeks later with persistence of his symptoms. Routine biochemical investigation revealed renal failure (Cr 623, Ur 29.9) and hyperkalaemia (K 7.2). Abdominal examination revealed a distended urinary bladder and an ultrasound scan revealed hydronephrosis, confirming the diagnosis of chronic high-pressure urinary retention. A urinary catheter was passed that initially drained 1.5 litre of clear urine. Shortly after insertion, this became heavily blood stained. A CT kidney ureter bladder (CTKUB) revealed a large mass behind the bladder thought to represent either an abscess or tumour. Cystoscopic correlation showed this to be a large, narrow-necked bladder diverticulum tensely distended with clot. Following successful clot evacuation and decompression of the bladder the leg swelling resolved and renal function improved.
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- 2012
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72. Association of vitamin D levels in coal miners: A case–control study
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Sanjay Dash, Sandhya Gupta, Venkatarao Epari, and Priti Yugma Patra
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25-hydroxyvitamin d ,coal miners ,parathormone ,Public aspects of medicine ,RA1-1270 - Abstract
Introduction: Coal miners working underground are likely to be at greater risk of developing Vitamin D deficiency due to reduced sunlight exposure. To date, only three studies have been reported, with no significant risk of Vitamin D deficiency among coal miners. None were conducted in the tropical region, where sunlight is ample. Objective: The present study estimated Vitamin D levels among underground coal miners in a tropical region and determined their associated factors. Methods: Serum calcium, 25-hydroxyvitamin D, and bone turnover markers among underground and surface workers were estimated in a matched case–control study. Binary logistic regression analysis was performed using case/control as the dependent variable to estimate odds ratios and 95% confidence intervals of variables which significantly (P < 0.1) differed among the cases and controls. Results: The mean Vitamin D level among both coal miners (22.12 ng/dl) and surface workers (23 ng/dl) were low. No significant difference was noted for all biochemical parameters after adjusting for other covariates except the parathyroid hormone (PTH), which was marginally higher among the surface workers. Conclusions: Even in the absence of statistically significant evidence of low Vitamin D level in underground workers compared to surface workers, there was indirect evidence (of differences in PTH) to indicate that Vitamin D level is lower in underground workers probably because of poor sunlight exposure.
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- 2020
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73. Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India
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Chetan Mahajan, Vaibhav Tiwari, Smita Subhash Divyaveer, Malagouda R Patil, Avinandan Banerjee, Vishnuvardhan Bagur, Umesh Dubey, Koushik Battacharjee, Sandeep Saini, Tanima Das Bhattacharya, Arpita Raychaudhury, Sanjay Dasgupta, Dipankar Sarkar, Anila Abraham Kurien, and Rajendra Pandey
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renal biopsy ,aki ,chronic kidney disease ,nephrotic syndrome ,glomerulonephritis ,thrombotic microangiopathy ,end-stage renal disease ,Therapeutics. Pharmacology ,RM1-950 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: Biopsy registries are important in studying the frequency of kidney diseases, their trends over time and allow comparison of data from different geographical regions. Objectives: We report the spectrum of biopsy-proven glomerular and tubular diseases in a single centre in Eastern India. Patients and Methods: Medical records of 1293 patients with biopsy-proven glomerular diseases (GDs) and tubular diseases over a period of three years (March 2013 to March 2016) were retrospectively analysed. All biopsy specimens were examined by the same pathologist with light and immunofluorescence microscopy. Electron microscopic (EM) analysis was performed only in selected cases. Histologic spectrum of various GDs was studied along with its correlation with the clinical and laboratory parameters. Results: The clinical diagnosis was nephrotic syndrome (NS) in 820 (63.41%), rapidly progressive glomerulonephritis in 194 (15.2%), asymptomatic urinary abnormalities (AUA) in 108 (8%), acute kidney injury (AKI)/acute nephritic syndrome in 118 (9.3%), and macroscopic hematuria (MH) in 3 (0.43%) patients. Male: Female ratio was 0.95. Around 22.42% were < 18 years, 72.2% were between 18to 59 years, and 5.3% were ≥ 60 years of age. The most common GD overall as well as primary glomerular disease (PGD) was minimal change disease (MCD) (21.6 and 83.44%). Secondary GD was present in 20.87%; most common being lupus nephritis (84.58%). Among the NS, the most common GD was MCD (33.17%), followed by FSGS (17.56%), membranous nephropathy (MN) (13.90%), lupus nephritis (LN) (9.39%), IgA-nephropathy (0.49%), and MPGN (7.32%). Thrombotic microangiopathy (TMA) constituted 24.6% of AKI presentation particularly common in pregnancy. Diffuse proliferative glomerulonephritis (DPGN) with severe renal dysfunction was present in 14% of elderly patients. Conclusion: The spectrum of GD varies according to the area of study and changes over time. Some entities which have not been reported earlier from this region that are uncommon but are significant were pregnancy associated TMA, C3 glomerulopathy (C3G) and DPGN in adults.
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- 2020
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74. Spectrum of renal allograft biopsy: A five-year experience at a tertiary care center of Eastern India
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Malagouda R Patil, Smita Subhash Divyaveer, Chetan Mahajan, Arpita Roy Choudhury, Sanjay Dasgupta, Dipankar Sarkar, Harmeet Riyait, Anila Abraham, and Rajendra Pandey
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Medicine - Abstract
Renal allograft dysfunction (RAD) can have myriad causes and presentations. Allograft biopsy remains the gold standard for optimum management. This is a retrospective study carried out at a tertiary care institute from August 2011 to March 2016. Details of the renal allograft biopsy requisitions were recorded and analyzed. Two hundred and two patients had undergone kidney transplantation (KT) during the study period. One hundred and twenty-six had undergone renal biopsy for RAD. The acute asymptomatic rise of serum creatinine was the most common clinical presentation (47.61%) followed by chronic RAD (CRAD) (19.84%), proteinuria (15.87%), immediate graft dysfunction (10.31%), and persistent active urinary sediments (6.34%) in that order. The incidence of delayed graft function was 1.98%. The overall incidence of biopsy-proven rejection was 8.41% within oneyear and 8.91% beyond oneyear of transplant. Acute cellular rejection (ACR) [with or without antibody-mediated rejection (AMR)] was found in 65%; AMR was found in 40% and 15% had both ACR and AMR. Borderline acute cell-mediated rejection was found in 22.5% of biopsies. CRAD was due to chronic rejection and chronic calcineurin inhibitor toxicity in only about one-fourth of the cases. Incidence of glomerulo-nephritis was 10.89% and most of these occurred two years after KT. Renal allograft biopsy was associated with minor complications in 3.17% of cases. Clinical presentations do not reliably distinguish the various causes of RAD. Allograft biopsy is a mainstay in the diagnosis of RAD and is safe. Results of live donor first transplantation using complement-dependent cytotoxi-city crossmatch are comparable to those programs using newer methods like solid-phase assays. However, the direct comparison of these results with other studies may not be completely applicable.
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- 2018
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75. A prospective trial of safety and efficacy of low-dose tacrolimus therapy in steroid resistant nephrotic syndrome
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Avinandan Banerjee, Smita Subhash Divyaveer, Praveen Malvade, Tanima Das Bhattacharya, Chetan Mahajan, Vaibhav Tiwari, Arpita Raychaudhury, Dipankar Sircar, Sanjay Dasgupta, Arunansu Bandyopadhyay, Debabrata Sen, and Rajendra Pandey
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Steroid resistant nephrotic syndrome ,Minimal change disease ,Focal segmental glomerulosclerosis ,Tacrolimus ,Kidney biopsy ,Trough level ,Interstitial fibrosis ,Tubular atrophy ,Therapeutics. Pharmacology ,RM1-950 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction: A Significant proportion of steroid-resistant nephrotic syndrome (SRNS) patients who do not achieve remission will progress to end-stage renal disease (ESRD). Objectives: Calcineurin inhibitors (CNIs) are recommended as a first line therapy in SRNS but the data on tacrolimus (TAC) and its potential nephrotoxicity in SRNS patients is limited. Patients and Methods: This is a prospective single arm study conducted at IPGMER Kolkata from August 2013 to December 2015. All SRNS patients underwent kidney biopsy before the initiation of therapy. Patients with identified secondary causes of FSGS, eGFR ≤ 45 mL/min/1.73 m2, or more than 5% of interstitial fibrosis and tubular atrophy (IFTA) on biopsy were excluded. TAC was given 0.075 mg/kg (adjusted to maintain TAC trough level i.e. T0 of 5-7 ng/mL) with low-dose steroids. Those who completed 12 months of TAC underwent second biopsy. Primary outcome was a percent of partial or complete remission (CR) or refractory. Secondary outcome was time to achieve remission, relapses, and proportion of patients who had adverse effects. Results: Thirty-two patients were enrolled. Overall remission was seen in 28 patients (87.5%). CR was seen in 17 (53.13%) and partial remission (PR) was seen in 11 (34.38%). Four patients (12.5%) were refractory to therapy. Average time to achieve PR was 72.53 ± 62.57days while average time to achieve CR was 63.84 ± 27.32 days. Mean TAC dose required was 1.75 ±0.86 mg. Thirteen patients (40.63%) had relapses. One patient needed admission for diarrhea. All other adverse effects were managed on outdoor basis. None required discontinuation of TAC therapy. Compared with the baseline biopsy two patients had increase in IFTA and another one developed IFTA on one year protocol biopsy. Conclusion: Low dose TAC maintaining trough levels (T0) of 5 to 7 ng/mL with low dose steroid is an effective option for patients with SRNS. It is well tolerated and efficacious in achieving remission.
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- 2018
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76. A Cross-sectional Prospective Study of Asymptomatic Urinary Abnormalities, Blood Pressure, and Body Mass Index in Healthy School Children
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Arpita Ray Chaudhury, Thumu Venkataramana Reddy, Smita Subhash Divyaveer, Krishna Patil, Mahesh Bennikal, Kanailal Karmakar, Suparna Chatterjee, Sanjay Dasgupta, Dipankar Sircar, and Rajendra Pandey
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asymptomatic urinary abnormalities ,body mass index ,obesity ,proteinuria ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Screening school children for urinary abnormalities is an inexpensive task but is not commonly undertaken in India. Although debated in western countries, its utility in early diagnosis of kidney disorders has been proved by studies from Asia. We examined the prevalence of asymptomatic urinary abnormalities (AUA), obesity, and hypertension in school children and analyzed data to identify potential risk factors among those detected with such abnormalities. Methods: Children and adolescents 8 to 18 years of age of either gender, attending 14 public schools in West Bengal, were screened prospectively from July 2013 to July 2016 for detecting asymptomatic urinary abnormalities by a spot urine test using a dipstick. Sociodemographic profile, medical examination (weight, height, and blood pressure), and questionnaire-based data were recorded. Results: A total of 11,000 children were screened. Of these, data from 9306 children were available for AUA, obesity, and hypertension. The prevalence rate was 7.44% (95% confidence interval [CI] = 6.91%−7.97%) for at least 1 AUA. Isolated hematuria was present in 5.2% (95% CI 4.75%−5.65%), whereas isolated proteinuria was present in 1.9% (95% CI = 1.62%−2.18%). The prevalence of prehypertension was 13.43% (95% CI = 12.74%−14.12%) and that of hypertension and abnormal body mass index was 4.05% (95% CI = 6.43%−7.47%) and 38.67 (95% CI = 37.68%−39.66%) respectively. Discussion: The prevalence rates of AUA were comparable with those in some Asian countries but higher than in most developed countries. Of children and adolescents 8 to 18 years of age, those 13 to 18 years had significantly more high risk factors such as AUA, hypertension, and obesity.
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- 2017
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77. Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted 2-(4-styrylphenyl)-1H-benzimidazole and N- substituted-3[4-(1H-benzimidazole-2-yl)-phenyl]-acrylic acid tert-butyl ester
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Ramanatham Vinodkumar, Sanjay Dashrath Vaidya, Bobba Venkata Siva Kumar, Umesh Nanasaheb Bhise, Shekar Bhaskar Bhirud, and Uday Chandrakant Mashelkar
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Organic chemistry ,QD241-441 - Published
- 2008
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