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68 results on '"Sands, Kara A"'

52. Dabigatran etexilate for secondary stroke prevention: the first year experience from a multicenter short-term registry

Author

Tsivgoulis, Georgios, primary, Krogias, Christos, additional, Sands, Kara A., additional, Sharma, Vijay K., additional, Katsanos, Aristeidis H., additional, Vadikolias, Konstantinos, additional, Papageorgiou, Sokratis G., additional, Heliopoulos, Ioannis, additional, Shiue, Harn, additional, Mitsoglou, Athina, additional, Liantinioti, Chrissoula, additional, Athanasiadis, Dimitrios, additional, Giannopoulos, Sotirios, additional, Piperidou, Charitomeni, additional, Voumvourakis, Konstantinos, additional, and Alexandrov, Andrei V., additional

Published
2014
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56. Abstract T MP28: High Rate of Symptomatic Intracranial Stenosis (sICS) in Patients Treated with Systemic Thrombolysis at a United States Stroke Belt Tertiary Care Center

Author

Sands, Kara A, primary, Bavarsad Shahripour, Reza, additional, Tsivgoulis, Georgios, additional, Lyerly, Michael J, additional, Kumar, Gyanendra, additional, Sisson, April, additional, Rawal, Pawan V, additional, Alvi, Muhammad, additional, Kapoor, Niren, additional, Houston, J. T, additional, and Alexandrov, Andrei V, additional

Published
2014
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57. Prospective, open-label safety study of intravenous recombinant tissue plasminogen activator in wake-up stroke.

Author

Barreto, Andrew D., Fanale, Christopher V., Alexandrov, Andrei V., Gaffney, Kevin C., Vahidy, Farhaan S., Nguyen, Claude B., Sarraj, Amrou, Rahbar, Mohammad, Grotta, James C., Savitz, Sean I., Sands, Kara A, Martin‐Schild, Sheryl, Navalkele, Digvijaya D., Lopez, George A., Wu, Tzu‐Ching, Gonzales, Nicole R., and Misra, Vivek

Subjects
THERAPEUTIC use of fibrinolytic agents, FIBRINOLYTIC agents, CEREBRAL hemorrhage, CLINICAL trials, COMPARATIVE studies, INTRAVENOUS therapy, RESEARCH methodology, MEDICAL cooperation, RECOMBINANT proteins, RESEARCH, STROKE, TIME, EVALUATION research, TISSUE plasminogen activator, TREATMENT effectiveness, SEVERITY of illness index, NIH Stroke Scale, THERAPEUTICS
Abstract

Objective: It is estimated that one of four ischemic strokes are noticed upon awakening and are not candidates for intravenous recombinant tissue plasminogen activator (rtPA) because their symptoms are >3 hours from last seen normal (LSN). We tested the safety of rtPA in a multicenter, single-arm, prospective, open-label study (NCT01183533) in patients with wake-up stroke (WUS).Methods: We aimed to enroll 40 WUS patients with disabling deficits. Patients were 18 to 80 years of age, National Institutes of Health Stroke Scale (NIHSS) ≤25, and selected only on the appearance of noncontrast computed tomography (ie, over one-third middle cerebral artery territory hypodensity). Standard-dose (0.9mg/kg) intravenous rtPA had to be started ≤3 hours of patient awakening. The primary safety outcome was symptomatic intracerebral hemorrhage (sICH) with preplanned stopping rules and data safety board oversight. Other endpoints included: asymptomatic intracerebral hemorrhage; clinical improvement in NIHSS; and 90-day modified Rankin Scale (mRS) score.Results: Between October 2010 and October 2013, all 40 preplanned patients were enrolled (50% men) at five stroke centers. Four patients (10%) were subsequently determined to be mimics. Patients had a mean age of 60.8, median NIHSS of 6.5 (range, 2-24), and received thrombolysis at a mean time of 10.3 ± 2.6 LSN and 2.6 ± 0.6 hours from awakening with deficits. No sICH or parenchymal hematomas occurred. At 3 months, 20 of 38 (52.6%) patients achieved excellent recovery with mRS scores of 0 or 1 (2 patients were lost to follow-up).Interpretation: Intravenous thrombolysis was safe in this prospective WUS study of patients selected by noncontrast CT. A randomized effectiveness trial appears feasible using a similar, pragmatic design. Ann Neurol 2016;80:211-218. [ABSTRACT FROM AUTHOR]

Published
2016
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58. Abstract 5: Management Of Intravenous tPA In Non-ICU Environments: Safety, Clinical Outcome, And Cost Savings

Author

Coleman, Kisha C, primary, Palazzo, Paola, additional, Shahripour, Reza B, additional, Brooks, Amy L, additional, Cronin, Mary A, additional, Sands, Kara A, additional, Lyerly, Michael J, additional, Sisson, April, additional, Houston, Thomas, additional, Rawal, Pawan, additional, Alvi, Muhammad, additional, Kapoor, Niren, additional, Albright, Karen C, additional, Boehme, Amelia K, additional, Alexandrov, Andrei V, additional, and Alexandrov, Anne W, additional

Published
2013
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59. Abstract WP277: Aggressive Blood Pressure Management: A Perceived Contraindication to IV-tPA

Author

Sands, Kara A, primary, Boehme, Amelia K, additional, Albright, Karen C, additional, Lyerly, Michael J, additional, Rawal, Pawan V, additional, Kapoor, Niren, additional, Houston, James T, additional, Alvi, Muhammad, additional, Shahripour, Reza Bavarsad, additional, Sisson, April, additional, Alexandrov, Anne W, additional, and Alexandrov, Andrei V, additional

Published
2013
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61. The Salmonella typhimuriumFlagellar Basal Body Protein FliE Is Required for Flagellin Production and to Induce a Proinflammatory Response in Epithelial Cells∗

Author

Reed, Katharine A., Hobert, Michael E., Kolenda, Claire E., Sands, Kara A., Rathman, Michelle, O'Connor, Miriam, Lyons, Sean, Gewirtz, Andrew T., Sansonetti, Philippe J., and Madara, James L.

Abstract

During apical colonization by Salmonella typhimurium, intestinal epithelial cells orchestrate a proinflammatory response that involves secretion of chemoattractants, predominantly interleukin-8, which coordinate neutrophil trans-epithelial migration at the site of infection. This host-pathogen interaction requires several S. typhimuriumgenes. To identify novel genes that participate in this pathogen-induced proinflammatory response, we created S. typhimuriumTn-10 transposon mutants and identified a single mutant with Tn-10 insertional inactivation within the fliEflagellar locus that was able to adhere to and invade intestinal epithelial cells normally but was unable to induce interleukin-8 secretion in host cells. The fliE-deficient mutant failed to secrete flagellin and lacked any surface assembly of flagellae. Unlike wild-type S. typhimurium, the fliE-deficient mutant did not activate the IκBα/NF-κB signaling pathway or induce the coordinated trans-epithelial migration of isolated human neutrophils. Transcomplementation of the fliE-deficient mutant with a wild-type fliE-harboring plasmid restored all defects and produced a wild-type S. typhimuriumphenotype. Furthermore, functional down-regulation of basolateral TLR5 completely inhibited the monolayers' ability to respond to both wild-type S. typhimuriumand purified flagellin but had no affect on tumor necrosis factor α-induced responses. We therefore conclude that S. typhimurium fliEis essential for flagellin secretion, flagellar assembly, and S. typhimurium-induced proinflammatory responses through basolateral TLR5 and is consistent with the emerging model of S. typhimuriumflagellin-induced inflammation.

Published
2002
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62. Abstract T P133.

Author

Bavarsad Shahripour, Reza, Tsivgoulis, Georgios, Sands, Kara A, Lyerly, Michael J, Kumar, Geyanendra, Bitaraf, Saeid, Sisson, April, Alexandrov, Anne W, and Alexandrov, Andrei V

Published
2014

63. Abstract W P54.

Author

Shiue, Harn J, Sands, Kara A, Bavarsad Shahripour, Reza, Bitaraf, Saeid, and Alexandrov, Andrei V

Published
2014

64. Abstract W P30.

Author

Bavarsad Shahripour, Reza, Sands, Kara A, Lyerly, Michael J, Kumar, Geyanendra, Sisson, April, Alexandrov, Anne W, Cure, Joel K, and Alexandrov, Andrei V

Published
2014

65. Abstract T MP28.

Author

Sands, Kara A, Bavarsad Shahripour, Reza, Tsivgoulis, Georgios, Lyerly, Michael J, Kumar, Gyanendra, Sisson, April, Rawal, Pawan V, Alvi, Muhammad, Kapoor, Niren, Houston, J. T, and Alexandrov, Andrei V

Published
2014

66. Abstract 5.

Author

Coleman, Kisha C, Palazzo, Paola, Shahripour, Reza B, Brooks, Amy L, Cronin, Mary A, Sands, Kara A, Lyerly, Michael J, Sisson, April, Houston, Thomas, Rawal, Pawan, Alvi, Muhammad, Kapoor, Niren, Albright, Karen C, Boehme, Amelia K, Alexandrov, Andrei V, and Alexandrov, Anne W

Published
2013

67. Abstract WP277.

Author

Sands, Kara A, Boehme, Amelia K, Albright, Karen C, Lyerly, Michael J, Rawal, Pawan V, Kapoor, Niren, Houston, James T, Alvi, Muhammad, Shahripour, Reza Bavarsad, Sisson, April, Alexandrov, Anne W, and Alexandrov, Andrei V

Published
2013

68. Abstract NS 4.

Author

Alexandrov, Anne W, Chaudhary, Asad A, Sisson, April, Sands, Kara, Rawal, Pawan, Shiue, Harn J, Fowler, Beth, Shahripour, Reza B, Albright, Karen C, and Alexandrov, Andrei V

Published
2012

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