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52. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents

Author

Axelrud, Luiza Kvitko, Sato, João Ricardo, Santoro, Marcos Leite, Talarico, Fernanda, Pine, Daniel Samuel, Rohde, Luis Augusto, Zugman, Andre, Junior, Edson Amaro, Bressan, Rodrigo Affonseca, Grassi-Oliveira, Rodrigo, Pan, Pedro Mario, Hoffmann, Maurício Scopel, Simioni, Andre Rafael, Guinjoan, Salvador Martin, Hakonarson, Hakon, Brietzke, Elisa, Gadelha, Ary, Pellegrino da Silva, Renata, Hoexter, Marcelo Queiroz, Miguel, Euripedes Constantino, Belangero, Sintia Iole, and Salum, Giovanni Abrahão

Published
2019
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54. An Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents.

Author

Hoffmann, Maurício Scopel, Moore, Tyler Maxwell, Axelrud, Luiza Kvitko, Tottenham, Nim, Pan, Pedro Mario, Miguel, Eurípedes Constantino, Rohde, Luis Augusto, Milham, Michael Peter, Satterthwaite, Theodore Daniel, and Salum, Giovanni Abrahão

Subjects
RELIABILITY (Personality trait), SEMANTICS, RESEARCH, ACCURACY, DATABASE management, CHILD Behavior Checklist, PATHOLOGICAL psychology, FACTOR analysis, QUESTIONNAIRES, DESCRIPTIVE statistics, STATISTICAL models, STATISTICAL correlation, PROXY
Abstract

Data aggregation in mental health is complicated by using different questionnaires, and little is known about the impact of item harmonization strategies on measurement precision. Therefore, we aimed to assess the impact of various item harmonization strategies for a target and proxy questionnaire using correlated and bifactor models. Data were obtained from the Brazilian High-Risk Study for Mental Conditions (BHRCS) and the Healthy Brain Network (HBN; N = 6,140, ages 5–22 years, 39.6% females). We tested six item-wise harmonization strategies and compared them based on several indices. The one-by-one (1:1) expert-based semantic item harmonization presented the best strategy as it was the only that resulted in scalar-invariant models for both samples and factor models. The between-questionnaires factor correlation, reliability, and factor score difference in using a proxy instead of a target measure improved little when all other harmonization strategies were compared with a completely at-random strategy. However, for bifactor models, between-questionnaire specific factor correlation increased from 0.05–0.19 (random item harmonization) to 0.43–0.60 (expert-based 1:1 semantic harmonization) in BHRCS and HBN samples, respectively. Therefore, item harmonization strategies are relevant for specific factors from bifactor models and had little impact on p -factors and first-order correlated factors when the child behavior checklist (CBCL) and strengths and difficulties questionnaire (SDQ) were harmonized. [ABSTRACT FROM AUTHOR]

Published
2024
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55. Irritability in Youth: A Critical Integrative Review

Author

Leibenluft, Ellen, primary, Allen, Laura, additional, Althoff, Robert, additional, Brotman, Melissa A., additional, Burke, Jeffrey D., additional, Carlson, Gabrielle, additional, Dickstein, Daniel, additional, Dougherty, Lea R., additional, Evans, Spencer, additional, Kircanski, Katharina, additional, Klein, Daniel, additional, Malone, Eleanor, additional, Mazefsky, Carla, additional, Nigg, Joel T., additional, Perlman, Susan B., additional, Pine, Daniel, additional, Roy, Amy, additional, Salum, Giovanni, additional, Shakeshaft, Amy, additional, Silver, Jamilah, additional, Stoddard, Joel, additional, Thapar, Anita, additional, Tseng, Wan-Ling, additional, Vidal-Ribas, Pablo, additional, Wakschlag, Lauren S., additional, Stringaris, Argyris, additional, and Burman, Charlotte, additional

Published
2023
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57. W27. POLYGENIC RISK SCORE AND HOUSEHOLD DEPRIVATION ARE RELATED TO INTERNALIZING SYMPTOMS IN YOUTH

Author

Belangero, Sintia, primary, De Oliveira, Adrielle, additional, Carvalho, Carolina, additional, Ota, Vanessa, additional, Bugiga, Amanda, additional, Pan, Pedro, additional, Mauer, Jessica, additional, Mari, Jair, additional, Santoro, Marcos, additional, Miguel, Euripedes, additional, Hoffmann, Mauricio, additional, and Salum, Giovanni, additional

Published
2023
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59. T96. APPLICATION OF POLYGENIC RISK SCORE METHODS IN ADMIXED BRAZILIAN POPULATION

Author

Sampaio, Rafaella Ormond, primary, Ito, Lucas, additional, Cuóco, Cássia, additional, Mauer, Jessica, additional, Ota, Vanessa, additional, Luiz, Matheus, additional, Martins, Adrielle, additional, Costa, Giovany, additional, Bressan, Rodrigo, additional, Gadelha, Ary, additional, Pan, Pedro, additional, Salum, Giovanni, additional, Belangero, Sintia, additional, and Santoro, Marcos, additional

Published
2023
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60. 17. ANCESTRY-AWARE MIXED MODEL GWAS OF MAJOR DEPRESSION CHARTS A PATH FOR INCLUSIVE AND DIVERSE GENETIC RESEARCH

Author

Meng, Xiangrui, primary, Giannakopoulou, Olga, additional, Navoly, Georgina, additional, Levey, Daniel, additional, Mitchell, Brittany, additional, Oliveira, Adrielle M, additional, Martin, Nicholas G, additional, Salum, Giovanni, additional, Stein, Murray B, additional, Gelernter, Joel, additional, Belangero, Sintia, additional, Ota, Vanessa, additional, McIntosh, Andrew, additional, Lewis, Cathryn, additional, and Kuchenbaecker, Karoline, additional

Published
2023
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62. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence

Author

de Araujo, Celia Maria, Zugman, Andre, Swardfager, Walter, Belangero, Sintia Iole Nogueira, Ota, Vanessa Kiyomi, Spindola, Leticia Maria, Hakonarson, Hakon, Pellegrino, Renata, Gadelha, Ary, Salum, Giovanni Abrahão, Pan, Pedro Mario, de Moura, Luciana Monteiro, Del Aquilla, Marco, Picon, Felipe Almeida, Amaro, Edson, Jr., Sato, João Ricardo, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto P., Miguel, Euripedes Constantino, Bressan, Rodrigo A., and Jackowski, Andrea Parolin

Published
2018
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63. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample

Author

Hoexter, Marcelo Q., Biazoli, Claudinei E., Jr., Alvarenga, Pedro G., Batistuzzo, Marcelo C., Salum, Giovanni A., Gadelha, Ary, Pan, Pedro M., Anés, Mauricio, Mancini-Martins, Leticia, Moura, Luciana M., Soriano-Mas, Carles, Del' Aquilla, Marco A.G., Amaro, Edson, Jr., Rohde, Luis A., Jackowski, Andrea P., Bressan, Rodrigo A., Miguel, Euripedes C., do Rosario, Maria C., and Sato, João R.

Published
2018
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67. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents

Author

Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Spindola, Leticia Maria, Pan, Pedro Mario, Simabucuro, Andressa, Xavier, Gabriela, Vieira-Fonseca, Tamiris, Zanardo, Evelin Aline, dos Santos, Felipe Rodolfo Camargo, Schäfer, Julia Luiza, Kulikowski, Leslie Domenici, Galante, Pedro A. F., Asprino, Paula Fontes, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Gadelha, Ary, Mari, Jair Jesus, Bressan, Rodrigo Affonseca, Salum, Giovanni Abrahao, and Belangero, Sintia Iole

Published
2020
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70. Functional Connectivity Development along the Sensorimotor-Association Axis Enhances the Cortical Hierarchy

Author

Luo, Audrey, primary, Sydnor, Valerie J., additional, Pines, Adam, additional, Larsen, Bart, additional, Alexander-Bloch, Aaron F., additional, Cieslak, Matthew, additional, Covitz, Sydney, additional, Chen, Andrew, additional, Esper, Nathalia Bianchini, additional, Feczko, Eric, additional, Franco, Alexandre R., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Houghton, Audrey, additional, Hu, Fengling, additional, Keller, Arielle S., additional, Kiar, Gregory, additional, Mehta, Kahini, additional, Salum, Giovanni A., additional, Tapera, Tinashe, additional, Xu, Ting, additional, Zhao, Chenying, additional, Fair, Damien A., additional, Salo, Taylor, additional, Shinohara, Russell T., additional, Milham, Michael P., additional, and Satterthwaite, Theodore D., additional

Published
2023
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72. Incidence of adverse events and comparative tolerability of selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for the treatment of anxiety, obsessive-compulsive, and stress disorders: a systematic review and network meta-analysis

Author

Gosmann, Natan Pereira, primary, Costa, Marianna de Abreu, additional, Jaeger, Marianna de Barros, additional, Frozi, Júlia, additional, Spanemberg, Lucas, additional, Manfro, Gisele Gus, additional, Cortese, Samuele, additional, Cuijpers, Pim, additional, Pine, Daniel Samuel, additional, and Salum, Giovanni Abrahão, additional

Published
2023
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74. Decreased comfort food intake and allostatic load in adolescents carrying the A3669G variant of the glucocorticoid receptor gene

Author

Rodrigues, Danitsa Marcos, Reis, Roberta Sena, Dalle Molle, Roberta, Machado, Tania Diniz, Mucellini, Amanda Brondani, Bortoluzzi, Andressa, Toazza, Rudineia, Pérez, Juliano Adams, Salum, Giovanni Abrahão, Agranonik, Marilyn, Minuzzi, Luciano, Levitan, Robert D., Buchweitz, Augusto, Franco, Alexandre Rosa, Manfro, Gisele Gus, and Silveira, Patrícia Pelufo

Published
2017
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75. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder

Author

Spindola, Leticia Maria, Pan, Pedro Mario, Moretti, Patricia Natalia, Ota, Vanessa Kiyomi, Santoro, Marcos Leite, Cogo-Moreira, Hugo, Gadelha, Ary, Salum, Giovanni, Manfro, Gisele Gus, Mari, Jair Jesus, Brentani, Helena, Grassi-Oliveira, Rodrigo, Brietzke, Elisa, Miguel, Euripedes Constantino, Rohde, Luis Augusto, Sato, João Ricardo, Bressan, Rodrigo Affonseca, and Belangero, Sintia Iole

Published
2017
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81. Translating measurement into practice: Brazilian norms for depressive symptom assessment with the Patient Health Questionnaire (PHQ-9)

Author

Damiano, Rodolfo Furlan, Hoffmann, Maurício Scopel, Gosmann, Natan Pereira, Pan, Pedro Mario, Miguel, Eurípedes Constantino, and Salum, Giovanni Abrahão

Subjects
Psychometrics, community psychiatry, measurement-based care, depression severity
Abstract

Objectives: To provide practical norms for measuring depressive symptoms with the Patient Health Questionnaire 9 (PHQ-9) in Brazil through a state-of-the-art psychometrics analysis. Methods: We used a large representative dataset from the 2019 Brazilian National Health Survey (Pesquisa Nacional de Saúde – 2019), which included 90,846 Brazilian citizens. To assess scale structure, we assessed a unidimensional model using confirmatory factor analysis. Item response theory was used to characterize the distribution of depressive symptoms. Summed- and mean-based PHQ-9 scores were then linked using item response theory-based scores in generalized additive models. Finally, percentiles, T scores, and a newly developed score, called the decimal score (D score), were generated to describe PHQ-9 norms for the Brazilian population. Results: Confirmatory factor analysis revealed a good fit to the unidimensional model, being invariant to age and sex. Item response theory captured item-level information about the latent trait (reliable from 1 to 3 SDs above the mean). Brazilian norms were presented using summed scores, T scores, and D scores. Conclusion: This is the first study to determine Brazilian norms for the PHQ-9 among a large representative sample using robust psychometric tools. More precise PHQ-9 scores are now available and may be widely used in primary and specialized clinical care settings.

Published
2023

82. Incidence of adverse events and comparative tolerability of selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for the treatment of anxiety, obsessive-compulsive, and stress disorders:A systematic review and network meta-analysis

Author

Gosmann, Natan Pereira, Costa, Marianna De Abreu, Jaeger, Marianna De Barros, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cortese, Samuele, Cuijpers, Pim, Pine, Daniel Samuel, and Salum, Giovanni Abrahão

Subjects
obsessive-compulsive disorder, antidepressants, anxiety, network meta-analysis
Abstract

Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) show similar efficacy as treatments for anxiety, obsessive-compulsive, and stress-related disorders. Hence, comparisons of adverse event rates across medications are an essential component of clinical decision-making. We aimed to compare patterns of adverse events associated with SSRIs and SNRIs in the treatment of children and adults diagnosed with these disorders through a network meta-analysis. We searched MEDLINE, PsycINFO, Embase, Cochrane, websites of regulatory agencies, and international registers from inception to 09 September 2022, for randomized controlled trials assessing the efficacy of SSRIs or SNRIs. We analyzed the proportion of participants experiencing at least one adverse event and incidence rates of 17 specific adverse events. We estimated incidence rates and odds ratios through network meta-analysis with random effects and three-level models. We analyzed 799 outcome measures from 80 studies (n = 21 338). Participants in medication groups presented higher rates of adverse events (80.22%, 95% CI 76.13-83.76) when compared to placebo groups (71.21%, 67.00-75.09). Nausea was the most common adverse event (25.71%, CI 23.96-27.54), while weight change was the least common (3.56%, 1.68-7.37). We found higher rates of adverse events of medications over placebo for most medications, except sertraline and fluoxetine. We found significant differences between medications for overall tolerability and for autonomic, gastrointestinal, and sleep-related symptoms. Adverse events are a common reason that patients discontinue SSRIs and SNRIs. Results presented here guide clinical decision-making when clinicians weigh one medication over another. This might improve treatment acceptability and compliance.

Published
2023

84. Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis

Author

Gosmann, Natan Pereira, Costa, Marianna de Abreu, Jaeger, Marianna de Barros, Motta, Luis Souza, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cuijpers, Pim, Pine, Daniel Samuel, and Salum, Giovanni Abrahão

Subjects
Noradrenaline -- Usage -- Patient outcomes, Obsessive-compulsive disorder -- Drug therapy -- Patient outcomes, Serotonin uptake inhibitors -- Usage -- Patient outcomes, Serotonin agonists -- Usage -- Patient outcomes, Post-traumatic stress disorder -- Drug therapy -- Patient outcomes, Anxiety -- Drug therapy -- Patient outcomes, Biological sciences
Abstract

Background Anxiety, obsessive-compulsive, and stress-related disorders frequently co-occur, and patients often present symptoms of several domains. Treatment involves the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), but data on comparative efficacy and acceptability are lacking. We aimed to compare the efficacy of SSRIs, SNRIs, and placebo in multiple symptom domains in patients with these diagnoses over the lifespan through a 3-level network meta-analysis. Methods and findings We searched for published and unpublished randomized controlled trials that aimed to assess the efficacy of SSRIs or SNRIs in participants (adults and children) with diagnosis of any anxiety, obsessive-compulsive, or stress-related disorder in MEDLINE, PsycINFO, Embase, and Cochrane Library from inception to 23 April 2015, with an update on 11 November 2020. We supplemented electronic database searches with manual searches for published and unpublished randomized controlled trials registered in publicly accessible clinical trial registries and pharmaceutical companies' databases. No restriction was made regarding comorbidities with any other mental disorder, participants' age and sex, blinding of participants and researchers, date of publication, or study language. The primary outcome was the aggregate measure of internalizing symptoms of these disorders. Secondary outcomes included specific symptom domains and treatment discontinuation rate. We estimated standardized mean differences (SMDs) with 3-level network meta-analysis with random slopes by study for medication and assessment instrument. Risk of bias appraisal was performed using the Cochrane Collaboration's risk of bias tool. This study was registered in PROSPERO (CRD42017069090). We analyzed 469 outcome measures from 135 studies (n = 30,245). All medications were more effective than placebo for the aggregate measure of internalizing symptoms (SMD -0.56, 95% CI -0.62 to -0.51, p < 0.001), for all symptom domains, and in patients from all diagnostic categories. We also found significant results when restricting to the most used assessment instrument for each diagnosis; nevertheless, this restriction led to exclusion of 72.71% of outcome measures. Pairwise comparisons revealed only small differences between medications in efficacy and acceptability. Limitations include the moderate heterogeneity found in most outcomes and the moderate risk of bias identified in most of the trials. Conclusions In this study, we observed that all SSRIs and SNRIs were effective for multiple symptom domains, and in patients from all included diagnostic categories. We found minimal differences between medications concerning efficacy and acceptability. This three-level network meta-analysis contributes to an ongoing discussion about the true benefit of antidepressants with robust evidence, considering the significantly larger quantity of data and higher statistical power when compared to previous studies. The 3-level approach allowed us to properly assess the efficacy of these medications on internalizing psychopathology, avoiding potential biases related to the exclusion of information due to distinct assessment instruments, and to explore the multilevel structure of transdiagnostic efficacy., Author(s): Natan Pereira Gosmann 1,2,*, Marianna de Abreu Costa 2, Marianna de Barros Jaeger 2, Luis Souza Motta 1, Júlia Frozi 1, Lucas Spanemberg 1,3, Gisele Gus Manfro 2, Pim [...]

Published
2021
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86. The science of child and adolescent mental health in Greece: a nationwide systematic review

Author

Koumoula, Anastasia, primary, Marchionatti, Lauro Estivalete, additional, Caye, Arthur, additional, Karagiorga, Vasiliki Eirini, additional, Balikou, Panagiota, additional, Lontou, Katerina, additional, Arkoulaki, Vicky, additional, Simioni, André, additional, Serdari, Aspasia, additional, Kotsis, Konstantinos, additional, Basta, Maria, additional, Kapsimali, Efi, additional, Mitropoulou, Andromachi, additional, Klavdianou, Nikanthi, additional, Zeleni, Domna, additional, Mitroulaki, Sotiria, additional, Botzaki, Anna, additional, Gerostergios, Giorgos, additional, Samiotakis, Giorgos, additional, Moschos, Giorgos, additional, Giannopoulou, Ioanna, additional, Papanikolaou, Katerina, additional, Aggeli, Katerina, additional, Scarmeas, Nikolaos, additional, Koulouvaris, Panagiotis, additional, Emanuele, Jill, additional, Schuster, Kenneth, additional, Karyotaki, Eirini, additional, Kalikow, Lily, additional, Pronoiti, Katerina, additional, Gosmann, Natan Pereira, additional, Schafer, Julia Luiza, additional, Merikangas, Kathleen R., additional, Szatmari, Peter, additional, Cuijpers, Pim, additional, Georgiades, Katholiki, additional, Milham, Michael P., additional, Corcoran, Mimi, additional, Burke, Sarah, additional, Koplewicz, Harold, additional, and Salum, Giovanni Abrahão, additional

Published
2023
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87. Understanding priorities and needs for child and adolescent mental health in Greece from multiple informants: an open resource

Author

Koumoula, Anastasia, primary, Marchionatti, Lauro Estivalete, additional, Karagiorga, Vasiliki Eirini, additional, Schafer, Julia Luiza, additional, Simioni, Andre, additional, Caye, Arthur, additional, Serdari, Aspasia, additional, Kotsis, Konstantinos, additional, Basta, Maria, additional, Athanasopoulou, Lilian, additional, Dafoulis, Vaios, additional, Tsatsiopoulou, Paraskevi, additional, Zilikis, Nikos, additional, Vergouli, Evangelia, additional, Balikou, Panagiota, additional, Kapsimali, Efi, additional, Mitropoulou, Andromachi, additional, Tzotzi, Alexandra, additional, Klavdianou, Nikanthi, additional, Zeleni, Domna, additional, Mitroulaki, Sotiria, additional, Botzaki, Anna, additional, Gerostergios, Giorgos, additional, Samiotakis, Giorgos, additional, Moschos, Giorgos, additional, Giannopoulou, Ioanna, additional, Papanikolaou, Katerina, additional, Angeli, Katerina, additional, Scarmeas, Nikolaos, additional, Emanuele, Jill, additional, Schuster, Kenneth, additional, Karyotaki, Eirini, additional, Kalikow, Lily, additional, Pronoiti, Katerina, additional, Merikangas, Kathleen R., additional, Szatmari, Peter, additional, Cuijpers, Pim, additional, Georgiades, Katholiki, additional, Milham, Michael P., additional, Corcoran, Mimi, additional, Burke, Sarah, additional, Koplewicz, Harold, additional, and Salum, Giovanni Abrahao, additional

Published
2023
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91. An Evaluation of Item Harmonization Strategies Between Assessment Tools of Psychopathology in Children and Adolescents

Author

Hoffmann, Maurício Scopel, primary, Moore, Tyler Maxwell, additional, Axelrud, Luiza Kvitko, additional, Tottenham, Nim, additional, Pan, Pedro Mario, additional, Miguel, Eurípedes Constantino, additional, Rohde, Luis Augusto, additional, Milham, Michael Peter, additional, Satterthwaite, Theodore Daniel, additional, and Salum, Giovanni Abrahão, additional

Published
2023
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93. Country-level gender inequality is associated with structural differences in the brains of women and men

Author

Zugman, André, Alliende, Luz María, Medel, Vicente, Bethlehem, Richard A.I., Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, Geraldo F., Castro, Mariana N., Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, de la Fuente-Sandoval, Camilo, Di Forti, Marta, Díaz-Caneja, Covadonga M., María Díaz-Zuluaga, Ana, Du Plessis, Stefan, Duran, Fabio L. S., Fittipaldi, Sol, Fornito, Alex, Freimer, Nelson B., Gadelha, Ary, Gama, Clarissa S., Garani, Ranjini, Garcia-Rizo, Clemente, Gonzalez Campo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, Pedro M., Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, Juan P., Reckziegel, Ramiro, Reis Marques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, Dan J., Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, Eduardo A., Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, Toby T., Yalin, Nefize, Zamorano, Francisco, Zanetti, Marcus V., cVEDA, Winkler, Anderson M., Pine, Daniel S., Evans-Lacko, Sara, Crossley, Nicolas A., Zugman, André, Alliende, Luz María, Medel, Vicente, Bethlehem, Richard A.I., Seidlitz, Jakob, Ringlein, Grace, Arango, Celso, Arnatkevičiūtė, Aurina, Asmal, Laila, Bellgrove, Mark, Benegal, Vivek, Bernardo, Miquel, Billeke, Pablo, Bosch-Bayard, Jorge, Bressan, Rodrigo, Busatto, Geraldo F., Castro, Mariana N., Chaim-Avancini, Tiffany, Compte, Albert, Costanzi, Monise, Czepielewski, Leticia, Dazzan, Paola, de la Fuente-Sandoval, Camilo, Di Forti, Marta, Díaz-Caneja, Covadonga M., María Díaz-Zuluaga, Ana, Du Plessis, Stefan, Duran, Fabio L. S., Fittipaldi, Sol, Fornito, Alex, Freimer, Nelson B., Gadelha, Ary, Gama, Clarissa S., Garani, Ranjini, Garcia-Rizo, Clemente, Gonzalez Campo, Cecilia, Gonzalez-Valderrama, Alfonso, Guinjoan, Salvador, Holla, Bharath, Ibañez, Agustín, Ivanovic, Daniza, Jackowski, Andrea, Leon-Ortiz, Pablo, Lochner, Christine, López-Jaramillo, Carlos, Luckhoff, Hilmar, Massuda, Raffael, McGuire, Philip, Miyata, Jun, Mizrahi, Romina, Murray, Robin, Ozerdem, Aysegul, Pan, Pedro M., Parellada, Mara, Phahladira, Lebogan, Ramirez-Mahaluf, Juan P., Reckziegel, Ramiro, Reis Marques, Tiago, Reyes-Madrigal, Francisco, Roos, Annerine, Rosa, Pedro, Salum, Giovanni, Scheffler, Freda, Schumann, Gunter, Serpa, Mauricio, Stein, Dan J., Tepper, Angeles, Tiego, Jeggan, Ueno, Tsukasa, Undurraga, Juan, Undurraga, Eduardo A., Valdes-Sosa, Pedro, Valli, Isabel, Villarreal, Mirta, Winton-Brown, Toby T., Yalin, Nefize, Zamorano, Francisco, Zanetti, Marcus V., cVEDA, Winkler, Anderson M., Pine, Daniel S., Evans-Lacko, Sara, and Crossley, Nicolas A.

Abstract

Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental experiences. Therefore, unequal exposure to harsher conditions for women compared to men in gender-unequal countries might be reflected in differences in their brain structure, and this could be the neural mechanism partly explaining women’s worse outcomes in gender-unequal countries. We examined this through a random-effects meta-analysis on cortical thickness and surface area differences between adult healthy men and women, including a meta-regression in which country-level gender inequality acted as an explanatory variable for the observed differences. A total of 139 samples from 29 different countries, totaling 7, 876 MRI scans, were included. Thickness of the right hemisphere, and particularly the right caudal anterior cingulate, right medial orbitofrontal, and left lateral occipital cortex, presented no differences or even thicker regional cortices in women compared to men in gender-equal countries, reversing to thinner cortices in countries with greater gender inequality. These results point to the potentially hazardous effect of gender inequality on women’s brains and provide initial evidence for neuroscience-informed policies for gender equality.

Published
2023

94. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.

Published
2023

95. Volume of subcortical brain regions in social anxiety disorder : mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adul

Published
2023
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96. Incidence of adverse events and comparative tolerability of selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for the treatment of anxiety, obsessive-compulsive, and stress disorders: A systematic review and network meta-analysis

Author

Gosmann, Natan Pereira, Costa, Marianna De Abreu, Jaeger, Marianna De Barros, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cortese, Samuele, Cuijpers, Pim, Pine, Daniel Samuel, Salum, Giovanni Abrahão, Gosmann, Natan Pereira, Costa, Marianna De Abreu, Jaeger, Marianna De Barros, Frozi, Júlia, Spanemberg, Lucas, Manfro, Gisele Gus, Cortese, Samuele, Cuijpers, Pim, Pine, Daniel Samuel, and Salum, Giovanni Abrahão

Abstract

Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) show similar efficacy as treatments for anxiety, obsessive-compulsive, and stress-related disorders. Hence, comparisons of adverse event rates across medications are an essential component of clinical decision-making. We aimed to compare patterns of adverse events associated with SSRIs and SNRIs in the treatment of children and adults diagnosed with these disorders through a network meta-analysis. We searched MEDLINE, PsycINFO, Embase, Cochrane, websites of regulatory agencies, and international registers from inception to 09 September 2022, for randomized controlled trials assessing the efficacy of SSRIs or SNRIs. We analyzed the proportion of participants experiencing at least one adverse event and incidence rates of 17 specific adverse events. We estimated incidence rates and odds ratios through network meta-analysis with random effects and three-level models. We analyzed 799 outcome measures from 80 studies (n = 21 338). Participants in medication groups presented higher rates of adverse events (80.22%, 95% CI 76.13-83.76) when compared to placebo groups (71.21%, 67.00-75.09). Nausea was the most common adverse event (25.71%, CI 23.96-27.54), while weight change was the least common (3.56%, 1.68-7.37). We found higher rates of adverse events of medications over placebo for most medications, except sertraline and fluoxetine. We found significant differences between medications for overall tolerability and for autonomic, gastrointestinal, and sleep-related symptoms. Adverse events are a common reason that patients discontinue SSRIs and SNRIs. Results presented here guide clinical decision-making when clinicians weigh one medication over another. This might improve treatment acceptability and compliance.

Published
2023
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97. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, Van der Wee, Nic J A, Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, and Van der Wee, Nic J A

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE = 0.037; right: d = -0.104, p FWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE < 0.001; right: d = -0.158, p FWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE = 0.006; right: d = 0.099, p FWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adol

Published
2023

99. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

Author

Moura, Luciana Monteiro, Kempton, Matthew, Barker, Gareth, Salum, Giovanni, Gadelha, Ary, Pan, Pedro Mario, Hoexter, Marcelo, Del Aquilla, Marco Antonio Gomes, Picon, Felipe Almeida, Anés, Mauricio, Otaduy, Maria Concepcion Garcia, Amaro, Edson, Jr, Rohde, Luis Augusto, McGuire, Philip, Bressan, Rodrigo Affonseca, Sato, João Ricardo, and Jackowski, Andrea Parolin

Published
2016
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