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56. The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations

Author

Mussazhanova, Zhanna, primary, Rogounovitch, Tatiana I., additional, Saenko, Vladimir A., additional, Krykpayeva, Ainur, additional, Espenbetova, Maira, additional, Azizov, Bauyrzhan, additional, Kondo, Hisayoshi, additional, Matsuda, Katsuya, additional, Kalmatayeva, Zhanna, additional, Issayeva, Raushan, additional, Yeleubayeva, Zhanar, additional, Madiyeva, Madina, additional, Mukanova, Aray, additional, Sandybayev, Marat, additional, Bolsynbekova, Saltanat, additional, Kozykenova, Zhanna, additional, Yamashita, Shunichi, additional, and Nakashima, Masahiro, additional

Published
2021
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59. Predictors of the efficacy of radioiodine therapy of Graves’ disease in children and adolescents

Author

Rumyantsev, Pavel O., primary, Saenko, Vladimir A., additional, Dzeytova, Dali S., additional, Trukhin, Alexey A., additional, Sheremeta, Marina S., additional, Slashchuk, Konstantin Yu., additional, Degtyarev, Mikhail V., additional, Serzhenko, Sergey S., additional, Yasuchenia, Valentina S., additional, Zakharova, Svetlana M., additional, and Sirota, Yaroslav I., additional

Published
2020
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61. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl

Author

Takahashi, Meiko, Saenko, Vladimir A., Rogounovitch, Tatiana I., Kawaguchi, Takahisa, Drozd, Valentina M., Takigawa-Imamura, Hisako, Akulevich, Natallia M., Ratanajaraya, Chanavee, Mitsutake, Norisato, Takamura, Noboru, Danilova, Larisa I., Lushchik, Maxim L., Demidchik, Yuri E., Heath, Simon, Yamada, Ryo, Lathrop, Mark, Matsuda, Fumihiko, and Yamashita, Shunichi

Published
2010
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69. Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses

Author

Mussazhanova, Zhanna, Miura, Shiro, Stanojevic, Boban, Rougounovitch, Tatiana, Saenko, Vladimir, Shiraishi, Toshio, Kurashige, Tomomi, Shichijo, Kazuko, Kaneko, Kenichi, Takahashi, Haruo, Ito, Masahiro, Nakashima, Masahiro, Mussazhanova, Zhanna, Miura, Shiro, Stanojevic, Boban, Rougounovitch, Tatiana, Saenko, Vladimir, Shiraishi, Toshio, Kurashige, Tomomi, Shichijo, Kazuko, Kaneko, Kenichi, Takahashi, Haruo, Ito, Masahiro, and Nakashima, Masahiro

Abstract

Background: Neuroendocrine tumor (NET) of the thyroid other than medullary carcinoma is extremely rare. We describe here a case of calcitonin-negative small cell neuroendocrine carcinoma (SCNEC), which occurred in a thyroid gland that had previously been irradiated at high dose (60Gy) for pharyngeal cancer, with molecular analyses for follicular cell origin. Patient Findings: The tumor cells were small with fine chromatin, inconspicuous nucleoli, and inapparent cytoplasm, and showed neuroendocrine architectures such as palisading, rosettes, and trabeculae. Mitotic figures were numerous exceeding 10 mitoses per 10 high-power fields. The tumor cells invaded into several vessels and metastasized to regional lymph nodes. Immunohistochemically, the tumor cells were strongly positive for neuroendocrine markers and thyroglobulin (Tg), a marker of thyroid follicular cells but negative for calcitonin and carcinoembryonic antigen (CEA). Expression of Tg and thyrotropin receptor (TSHR) were confirmed by quantitative real-time polymerase chain reaction (RT-PCR). Ki-67 labeling index was more than 70% in the tumor cells. Taken together, the tumor was diagnosed as SCNEC of the thyroid. Genetic analyses also revealed microsatellite abnormalities of the phosphatase and tensin homolog (PTEN) gene, suggesting that functional loss of PTEN contributes to carcinogenesis. Conclusions: This is the first report describing a SCNEC of the thyroid with molecular analyses that provide evidence for a follicular epithelial origin., identifier:Thyroid, 24(3), pp.593-598; 2014

Published
2020

70. Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer.

Author

Rumyantsev, Pavel O, Saenko, Vladimir A, Ilyin, Alexey A, Stepanenko, Valery F, Rumyantseva, Ulyana V, Abrosimov, Aleksandr Yu, Lushnikov, Evgeny F, Rogounovitch, Tatiana I, Shibata, Yoshisada, Mitsutake, Norisato, Tsyb, Anatoly F, Yamashita, Shunichi, Rumyantsev, Pavel O, Saenko, Vladimir A, Ilyin, Alexey A, Stepanenko, Valery F, Rumyantseva, Ulyana V, Abrosimov, Aleksandr Yu, Lushnikov, Evgeny F, Rogounovitch, Tatiana I, Shibata, Yoshisada, Mitsutake, Norisato, Tsyb, Anatoly F, and Yamashita, Shunichi

Abstract

Papillary thyroid carcinoma (PTC) in patients exposed to environmental radioiodine after the Chernobyl accident is thought to have a relatively aggressive clinical course. Long-term results of treatment are not well known, especially in comparison with sporadic PTC., identifier:Journal of Clinical Endocrinology and Metabolism, 96(2), pp.385-393; 2011

Published
2020

73. Low Frequency of BRAFT1796A Mutations in Childhood Thyroid Carcinomas

Author

Kumagai, Atsushi, Namba, Hiroyuki, Saenko, Vladimir A., Ashizawa, Kiyoto, Ohtsuru, Akira, Ito, Masahiro, Ishikawa, Naofumi, Sugino, Kiminori, Ito, Koichi, Jeremiah, Stephen, Thomas, Geraldine A., Bogdanova, Tatyana I., Tronko, Mykola D., Nagayasu, Takeshi, Shibata, Yoshisada, and Yamashita, Shunichi

Published
2004

81. Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report

Author

Stanojevic Boban, Dzodic Radan, Saenko Vladimir, Milovanovic Zorka, Krstevski Vesna, Radlovic Petar, Buta Marko, Rulic Bozidar, Todorovic Lidija, Dimitrijevic Bogomir, and Yamashita Shunichi

Subjects
Struma ovarii, Follicular variant of papillary thyroid carcinoma, KRAS mutation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Struma ovarii (SO) is a rare form of ovarian mature teratoma in which thyroid tissue is the predominant element. Because of its rarity, the differential diagnosis between benign and malignant SO has not been clearly defined. It is believed that malignant transformation of SO has similar molecular features with and its prognosis corresponds to that of malignant tumors originating in the thyroid. Case presentation We report 35-year-old woman with bilateral ovarian cysts incidentally detected by ultrasound during the first trimester of pregnancy. Four months after delivery of a healthy child without complication she was admitted to the hospital for acute abdominal pain. Laparoscopic left adnexectomy was performed initially in a regional hospital; right cystectomy was done later in a specialized clinic. Intraoperative frozen section and a final pathology revealed that the cyst from the left ovary was composed of mature teratomatous elements, normal thyroid tissue (>50%) and a non-encapsulated focus of follicular variant of papillary thyroid carcinoma (PTC). Normal and cancerous thyroid tissues were tested for BRAF and RAS mutations by direct sequencing, and for RET/PTC rearrangements by RT-PCR/Southern blotting. A KRAS codon 12 mutation, the GGT → GTT transversion, corresponding to the Gly → Val amino acid change was identified in the absence of other genetic alterations commonly found in PTC. Conclusion To the best of our knowledge, this is the first time this mutation is described in a papillary thyroid carcinoma arising in struma in the ovarii. This finding provides further evidence that even rare mutations specific for PTC may occur in such tumors. Molecular testing may be a useful adjunct to common differential diagnostic methods of thyroid malignancy in SO.

Published
2012
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84. TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas

Author

Tanaka, Aya, primary, Matsuse, Michiko, additional, Saenko, Vladimir, additional, Nakao, Tomoe, additional, Yamanouchi, Kosho, additional, Sakimura, Chika, additional, Yano, Hiroshi, additional, Nishihara, Eijun, additional, Hirokawa, Mitsuyoshi, additional, Suzuki, Keiji, additional, Miyauchi, Akira, additional, Eguchi, Susumu, additional, Yoshiura, Ko-ichiro, additional, Yamashita, Shunichi, additional, Nagayasu, Takeshi, additional, and Mitsutake, Norisato, additional

Published
2019
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88. Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature

Author

Buta Marko, Pupic Gordana, Markovic Ivan, Nakashima Masahiro, Saenko Vladimir, Stanojevic Boban, Dzodic Radan, Inic Momcilo, Rogounovitch Tatiana, and Yamashita Shunichi

Subjects
Pathology, RB1-214
Abstract

Abstract The presence of ectopic breast tissue in axillary lymph nodes (ALN) is a benign condition that must be differentiated from primary or metastatic carcinoma. Here we report a patient who underwent excision of enlarged ALN 10 years after she had received surgical treatment of ipsilateral breast for an intracystic intraductal papilloma (IDP). Histological examination of the removed ALN revealed that the proliferative lesion consisted of papillary and tubular structures lined by luminal cuboidal cells and a distinct outer layer of myoepithelial cells resembling IDP of the breast. Immunostaining with a set of immunohistochemical markers including AE/AE3, alpha-smooth muscle actin and p63 in combination with estrogen and progesterone receptors confirmed the diagnosis of ectopic IDP. This case shows that even though benign proliferative change in ectopic breast tissue is an extremely rare phenomenon, this possibility should be taken into account for correct diagnosis.

Published
2010
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90. Radiation-Induced Thyroid Cancers: Overview of Molecular Signatures

Author

Suzuki, Keiji, Saenko, Vladimir, Yamashita, Shunichi, Mitsutake, Norisato, Suzuki, Keiji, Saenko, Vladimir, Yamashita, Shunichi, and Mitsutake, Norisato

Abstract

Enormous amounts of childhood thyroid cancers, mostly childhood papillary thyroid carcinomas (PTCs), after the Chernobyl nuclear power plant accident have revealed a mutual relationship between the radiation exposure and thyroid cancer development. While the internal exposure to radioactive 131I is involved in the childhood thyroid cancers after the Chernobyl accident,people exposed to the external radiation, such as atomic-bomb (A-bomb) survivors, and the patients who received radiation therapy, have also been epidemiologically demonstrated to develop thyroid cancers. In order to elucidate the mechanisms of radiation-induced carcinogenesis, studies have aimed at defining the molecular changes associated with the thyroid cancer development. Here,we overview the literatures towards the identification of oncogenic alterations, particularly gene rearrangements, and discuss the existence of radiation signatures associated with radiation-induced thyroid cancers., Cancers, 11(9), art.no.1290; 2019

Published
2019

91. TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas

Author

Tanaka, Aya, Matsuse, Michiko, Saenko, Vladimir, Nakao, Tomoe, Yamanouchi, Kosho, Sakimura, Chika, Yano, Hiroshi, Nishihara, Eijun, Hirokawa, Mitsuyoshi, Suzuki, Keiji, Miyauchi, Akira, Eguchi, Susumu, Yoshiura, Ko-ichiro, Yamashita, Shunichi, Nagayasu, Takeshi, Mitsutake, Norisato, Tanaka, Aya, Matsuse, Michiko, Saenko, Vladimir, Nakao, Tomoe, Yamanouchi, Kosho, Sakimura, Chika, Yano, Hiroshi, Nishihara, Eijun, Hirokawa, Mitsuyoshi, Suzuki, Keiji, Miyauchi, Akira, Eguchi, Susumu, Yoshiura, Ko-ichiro, Yamashita, Shunichi, Nagayasu, Takeshi, and Mitsutake, Norisato

Abstract

Telomerase reverse transcriptase (TERT) promoter mutations have been found in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor aggressiveness and worse prognosis. However, little is known about the status of TERT mRNA expression and its relationship between TERT promoter mutations and clinicopathological features. Methods: We analyzed 159 PTC samples for TERT promoter mutations using direct DNA sequencing. TERT expression was measured using quantitative reverse transcription polymerase chain reaction. To examine low allelic frequency of TERT promoter mutations with high sensitivity, we used droplet digital polymerase chain reaction (ddPCR). The relationship between the status of the TERT promoter mutation/expression and clinicopathological features including recurrence risk was statistically analyzed. Results: TERT promoter mutations were found in 20 cases (12.6%). However, TERT expression was observed not only in the mutation-positive tumors but also in 56 of 139 (40.3%) mutation-negative tumors. Among them, we detected low allelic frequency of TERT promoter mutations in three samples (5.4%) using ddPCR. We confirmed a significant association between TERT promoter mutations and aggressive clinicopathological features in this series. The risk of recurrence of TERT mutation-negative/expression-positive tumors was significantly higher than that of the mutation-negative/expression-negative tumors, suggesting that TERT expression even in absence of a mutation confers a negative influence on PTCs. Moreover, when we reclassified the mutation-negative cases into two groups based on the TERT expression levels: expression-negative/expression levels <80th percentile and expression levels >80th percentile because minimal expression may have a negligible clinical impact, a higher hazard ratio for recurrence was observed. Interestingly, TERT expression levels in the mutation-negative PTCs were inversely correlated with patient age and the presence of, Thyroid, 29(8), pp.1105-1114; 2019

Published
2019

100. Comparative Histopathologic Analysis of “Radiogenic” and “Sporadic” Papillary Thyroid Carcinoma: Patients Born Before and After the Chernobyl Accident

Author

Bogdanova, Tetiana I., primary, Saenko, Vladimir A., additional, Brenner, Alina V., additional, Zurnadzhy, Liudmyla Yu., additional, Rogounovitch, Tatiana I., additional, Likhtarov, Ilya A., additional, Masiuk, Sergii V., additional, Kovgan, Leonila M., additional, Shpak, Victor M., additional, Thomas, Geraldine A., additional, Chanock, Stephen J., additional, Mabuchi, Kiyohiko, additional, Tronko, Mykola D., additional, and Yamashita, Shunichi, additional

Published
2018
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