51. Efficacy of Sitagliptin on Cardiovascular Responses, Antioxidant Activity and Some Metabolic Aspects among STZ Induced-Diabetic Rats.
- Author
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Metwally, Aya Sh.
- Subjects
- *
LABORATORY rats , *TYPE 2 diabetes , *ELLAGIC acid , *BLOOD cholesterol , *SITAGLIPTIN , *BLOOD pressure , *CHOLESTEROL content of food - Abstract
Diabetes mellitus type II is a metabolic disorder in glucose utilization due to inability of the body's cells to use insulin hormones. Consequently, the blood-glucose level is increasing leading to other complications, including a rise of blood cholesterol level and elevated blood pressure. The current study was intended to evaluate the efficacy and protective role of sitagliptin on diabetic adult male rats. To achieve this goal, STZ induce diabetic rats were administrated sitagliptin (10 mg/kg b.wt.) orally once daily for 30 successive days. The attained results showed a significant decrease in blood glucose, TG, cholesterol, LDL and MDA of diabetic rats treated with sitagliptin. In addition, an improvement in the levels of blood insulin H., HOMA-IR, HDL and CAT enzyme was observed compared to the diabetic non treated rats. Moreover, sitagliptin was positively reflected on vascular responses of isolated aortic strips, heart rate and blood pressure values of the diabetic treated rats. In conclusion, the effectiveness and safety of sitagliptin for maintaining normoglycemic and normolipidemic levels. Along with its positive impact on antioxidant activity and vascular response during the treatment of diabetic rats, which could be considered as an additive value to DPP4- antagonists group. [ABSTRACT FROM AUTHOR]
- Published
- 2021