51. The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group
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Kenan Turgutalp, Egemen Cebeci, Aydin Turkmen, Ulver Derici, Nurhan Seyahi, Necmi Eren, Fatih Dede, Mustafa Gullulu, Taner Basturk, Gulizar Manga Sahin, Murvet Yilmaz, Savas Sipahi, Garip Sahin, Sena Ulu, Erhan Tatar, Ali Gundogdu, Rumeyza Turan Kazancioglu, Can Sevinc, Ozkan Gungor, İdris Sahin, Sim Kutlay, Ilhan Kurultak, Zeki Aydin, Bulent Altun, Belda Dursun, Zulfikar Yilmaz, Ozcan Uzun, Gultekin Suleymanlar, Ferhan Candan, Siren Sezer, Derya Basak Tanburoglu, Zerrin Bicik Bahcebasi, Dilek Taymez, Esra Akcali, Deren Oygar, Zulal Istemihan, Simge Bardak, Omer Faruk Akcay, Mevlut Tamer Dincer, Erkan Dervisoglu, Ezgi Yenigun, Kultigin Turkmen, and Savas Ozturk
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IgA nephropathy ,Glomerular IgG staining ,Renal prognostic factors ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.
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- 2021
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