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365 results on '"SCRUTINIO, DOMENICO"'

51. Deceptive meaning of oxygen uptake measured at the anaerobic threshold in patients with systolic heart failure and atrial fibrillation

Author

Magrì, Damiano, Agostoni, Piergiuseppe, Corrà, Ugo, Passino, Claudio, Scrutinio, Domenico, Perrone-Filardi, Pasquale, Correale, Michele, Cattadori, Gaia, Metra, Marco, Girola, Davide, Piepoli, Massimo F, Iorio, AnnaMaria, Emdin, Michele, Raimondo, Rosa, Re, Federica, Cicoira, Mariantonietta, Belardinelli, Romualdo, Guazzi, Marco, Limongelli, Giuseppe, Clemenza, Francesco, Parati, Gianfranco, Frigerio, Maria, Casenghi, Matteo, Scardovi, Angela B, Ferraironi, Alessandro, Di Lenarda, Andrea, Bussotti, Maurizio, Apostolo, Anna, Paolillo, Stefania, La Gioia, Rocco, Gargiulo, Paola, Palermo, Pietro, Minà, Chiara, Farina, Stefania, Battaia, Elisa, Maruotti, Antonello, Pacileo, Giuseppe, Contini, Mauro, Oliva, Fabrizio, Ricci, Roberto, and Sinagra, Gianfranco

Published
2015
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57. Malnutrition in patients admitted to in-hospital cardiac rehabilitation: Clinical correlates and association with mortality.

Author

Passantino, Andrea, Guida, Pietro, Rizzo, Caterina, Carbonara, Rosa, Ruggieri, Roberta, and Scrutinio, Domenico

Subjects
CARDIAC rehabilitation, MALNUTRITION, NUTRITIONAL assessment, SERUM albumin, CARDIAC surgery, TREATMENT programs, ARM circumference
Abstract

Malnutrition is highly prevalent among hospitalized patients; thus, an accurate identification of malnutrition could improve the outcome of these patients. The aim of the present paper was to apply multiple methods to evaluate the prevalence of malnutrition and clinical correlates in patients admitted to in-hospital cardiac rehabilitation. We performed a prospective study of 426 patients admitted to in-hospital cardiac rehabilitation: 282 (66.2%) had undergone a major cardiac surgery and 144 (34.8%) had experienced heart failure. The albumin level and mini nutritional assessment (MNA) scores were applied to evaluate the nutritional status of these patients. Serum albumin levels were < 3.5 g/dl in 147 (34.5%) patients, and MNA scores were < 24 in 179 (42.0%) patients. Patients with malnutrition or a risk of malnutrition had lower haemoglobin values, lower EuroQol scores and poorer functional status. Female gender, age, functional status and cumulative illness rating scale severity were predictors of malnutrition. Over a median follow-up of 47 months, MNA scores <24 were associated with higher mortality, even after correction for confounding variables. In conclusion, in patients admitted to in-hospital cardiac rehabilitation, malnutrition and risk of malnutrition frequently occur and are associated with poor functional status, higher clinical complication rates and long-term mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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63. Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction: a long-term comparison

Author

Agostoni, Piergiuseppe, Paolillo, Stefania, Mapelli, Massimo, Gentile, Piero, Salvioni, Elisabetta, Veglia, Fabrizio, Bonomi, Alice, Corrà , Ugo, Lagioia, Rocco, Limongelli, Giuseppe, Sinagra, Gianfranco, Cattadori, Gaia, Scardovi, Angela B., Metra, Marco, Carubelli, Valentina, Scrutinio, Domenico, Raimondo, Rosa, Emdin, Michele, Piepoli, Massimo, Magrì, Damiano, Parati, Gianfranco, Caravita, Sergio, Re, Federica, Cicoira, Mariantonietta, Minà , Chiara, Correale, Michele, Frigerio, Maria, Bussotti, Maurizio, Oliva, Fabrizio, Battaia, Elisa, Belardinelli, Romualdo, Mezzani, Alessandro, Pastormerlo, Luigi, Guazzi, Marco, Badagliacca, Roberto, Di Lenarda, Andrea, Passino, Claudio, Sciomer, Susanna, Zambon, Elena, Pacileo, Giuseppe, Ricci, Roberto, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Clemenza, Francesco, Marchese, Giovanni, Gargiulo, Paola, Binno, Simone, Lombardi, Carlo, Passantino, Andrea, Filardi, Pasquale Perrone, Agostoni, P, Paolillo, S, Mapelli, M, Gentile, P, Salvioni, E, Veglia, F, Bonomi, A, Corrà, U, Lagioia, R, Limongelli, G, Sinagra, G, Cattadori, G, Scardovi, A, Metra, M, Carubelli, V, Scrutinio, D, Raimondo, R, Emdin, M, Piepoli, M, Magrì, D, Parati, G, Caravita, S, Re, F, Cicoira, M, Minà, C, Correale, M, Frigerio, M, Bussotti, M, Oliva, F, Battaia, E, Belardinelli, R, Mezzani, A, Pastormerlo, L, Guazzi, M, Badagliacca, R, Di Lenarda, A, Passino, C, Sciomer, S, Zambon, E, Pacileo, G, Ricci, R, Apostolo, A, Palermo, P, Contini, M, Clemenza, F, Marchese, G, Gargiulo, P, Binno, S, Lombardi, C, Passantino, A, Filardi, P, Scardovi, Ab, CARAVITA DI TORITTO, Beniamino, Perrone Filardi, P., Agostoni, P., Paolillo, S., Mapelli, M., Gentile, P., Salvioni, E., Veglia, F., Bonomi, A., Corra, U., Lagioia, R., Limongelli, G., Sinagra, G., Cattadori, G., Scardovi, A. B., Metra, M., Carubelli, V., Scrutinio, D., Guarino, Raimondo, Emdin, M., Piepoli, M., Magri, D., Parati, G., Caravita, S., Re, F., Cicoira, M., Mina, C., Correale, M., Frigerio, M., Bussotti, M., Oliva, F., Battaia, E., Belardinelli, R., Mezzani, A., Pastormerlo, L., Guazzi, M., Badagliacca, R., Di Lenarda, A., Passino, C., Sciomer, S., Zambon, E., Pacileo, G., Ricci, R., Apostolo, A., Palermo, P., Contini, M., Clemenza, F., Marchese, G., Gargiulo, P., Binno, S., Lombardi, C., Passantino, A., Filardi, P. P., Agostoni, Piergiuseppe, Paolillo, Stefania, Mapelli, Massimo, Gentile, Piero, Salvioni, Elisabetta, Veglia, Fabrizio, Bonomi, Alice, Corrã , Ugo, Lagioia, Rocco, Limongelli, Giuseppe, Sinagra, Gianfranco, Cattadori, Gaia, Scardovi, Angela B., Metra, Marco, Carubelli, Valentina, Scrutinio, Domenico, Raimondo, Rosa, Emdin, Michele, Piepoli, Massimo, Magrã¬, Damiano, Parati, Gianfranco, Caravita, Sergio, Re, Federica, Cicoira, Mariantonietta, Minã , Chiara, Correale, Michele, Frigerio, Maria, Bussotti, Maurizio, Oliva, Fabrizio, Battaia, Elisa, Belardinelli, Romualdo, Mezzani, Alessandro, Pastormerlo, Luigi, Guazzi, Marco, Badagliacca, Roberto, Di Lenarda, Andrea, Passino, Claudio, Sciomer, Susanna, Zambon, Elena, Pacileo, Giuseppe, Ricci, Roberto, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Clemenza, Francesco, Marchese, Giovanni, Gargiulo, Paola, Binno, Simone, Lombardi, Carlo, Passantino, Andrea, and Filardi, Pasquale Perrone

Subjects
Male, Time Factors, Heart-Assist Device, Time Factor, Prognosi, Reproducibility of Result, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Heart failure, Risk Assessment, Follow-Up Studie, Oxygen Consumption, HFSS, Cause of Death, MECKI score, Prognosis, Risk score, SHFM, Exercise Test, Female, Follow-Up Studies, Heart Failure, Heart Transplantation, Heart-Assist Devices, Humans, Italy, Middle Aged, Morbidity, Prospective Studies, Reproducibility of Results, Stroke Volume, Survival Rate, Disease Management, heart failure, prognosis, heart failure, prognosis, risk score, cardiology and cardiovascular medicine, Prospective Studie, Human
Abstract

Aims: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction. Methods and results: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively). Conclusion: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.

Published
2018

64. Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients

Author

Agostoni, Piergiuseppe, Emdin, Michele, Corrà, Ugo, Veglia, Fabrizio, Magrì, Damiano, Tedesco, Calogero C., Berton, Emanuela, Passino, Claudio, Bertella, Erika, Re, Federica, Mezzani, Alessandro, Belardinelli, Romualdo, Colombo, Chiara, La Gioia, Rocco, Vicenzi, Marco, Giannoni, Alberto, Scrutinio, Domenico, Giannuzzi, Pantaleo, Tondo, Claudio, Di Lenarda, Andrea, Sinagra, Gianfranco, Piepoli, Massimo F., and Guazzi, Marco

Published
2008

70. Right heart dysfunction

Author

Mercurio, Valentina, primary, Palazzuoli, Alberto, additional, Correale, Michele, additional, Lombardi, Carlo, additional, Passantino, Andrea, additional, Ravera, Alice, additional, Ruocco, Gaetano, additional, Sciatti, Edoardo, additional, Triggiani, Marco, additional, Lagioia, Rocco, additional, Scrutinio, Domenico, additional, Tocchetti, Carlo G., additional, and Nodari, Savina, additional

Published
2018
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71. Thrombolysis in unstable angina: results of clinical studies

Author

Scrutinio, Domenico, Biasco, Maria Giuseppa, and Rizzon, Paolo

Subjects
Unstable angina -- Care and treatment, Thrombolytic therapy -- Health aspects, Thrombolytic therapy -- Evaluation, Thrombosis -- Prevention, Atherosclerotic plaque -- Drug therapy, Health
Abstract

Most cases of unstable angina appear to be related to the formation of blood clots at the site of a ruptured atherosclerotic plaque. These blood clots, or thrombi, may restrict blood flow to the heart. Furthermore, an established blood clot within an atherosclerotic plaque may serve to promote the formation of thromboemboli, or blood clots that pass within the circulation and jam smaller arteries. This unstable condition is highly likely to lead to a heart attack or sudden death. A reasonable approach to therapy might be directed at this clotting process. Indeed, studies have shown that heparin, a powerful inhibitor of clotting, improves the survival of patients with unstable angina. It is less certain, however, whether any benefits may be gained by treatment with thrombolytic agents. Thrombolytic agents are enzymes that help dissolve clots and include plasminogen activator and streptokinase. Since streptokinase is most effective for new clots, plasminogen activator (PA) is considered to be the best candidate for use against aging clots which may be present at the site of a ruptured plaque. Both streptokinase and PA have proved effective in the treatment of acute myocardial infarction, which is also the result of a thrombus. However, some studies have failed to indicate any substantial advantage in using PA in the treatment of unstable angina. In at least some cases, the failure to demonstrate any advantage may be the result of including too few patients in the study group. The findings of large studies underway in the United States and Europe should resolve this question. It is critical that significant benefits be demonstrated conclusively, since treatment with PA has serious side effects. As many as one percent of patients treated with PA may suffer intracranial hemorrhages resulting in serious impairment or death. Among patients who may not survive an acute myocardial infarction, this risk may be worth taking. In contrast, the same risk of hemorrhage may not be appropriate for patients with unstable angina, particularly if the clinical benefit is not large. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

72. Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction

Author

Scrutinio, Domenico, Agostoni, Piergiuseppe, Gesualdo, Loreto, Corra, Ugo, Mezzani, Alessandro, Piepoli, Massimo, Di Lenarda, Andrea, Iorio, Annamaria, Passino, Claudio, Magri, Damiano, Masarone, Daniele, Battaia, Elisa, Girola, Davide, Re, Federica, Cattadori, Gaia, Parati, Gianfranco, Sinagra, Gianfranco, Villani, Giovanni Quinto, LIMONGELLI, Giuseppe, Pacileo, Giuseppe, Guazzi, Marco, Metra, Marco, Frigerio, Maria, Cicoira, Mariantonietta, Miná, Chiara, Malfatto, Gabriella, Caravita, Sergio, Bussotti, Maurizio, Salvioni, Elisabetta, Veglia, Fabrizio, Correale, Michele, Scardovi, Angela B., Emdin, Michele, Giannuzzi, Pantaleo, Gargiulo, Paola, Giovannardi, Marta, Perrone Filardi, Pasquale, Raimondo, Rosa, Ricci, Roberto, Paolillo, Stefania, Farina, Stefania, Belardinelli, Romualdo, Passantino, Andrea, La Gioia, Rocco, Fiorentini, Cesare, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Bertella, Erika, Mantegazza, Valentina, Pietrucci, Francesca, Ferraironi, Aessandro, Casenghi, Matteo, Clemenza, Francesco, Roselli, Teo, Buono, Andrea, Santoro, Daniela, Campanale, Saba, Caputo, Domenica, Bertipaglia, Donatella, Vaninetti, Raffaella, Confalonieri, Marco, Zambon, Elena, Berton, Emanuela, Torregiani, Chiara, Cas, Livio Dei, Carubelli, Valentina, Binno, Simone, Marchese, Giovanni, Oliva, Fabrizio, Pastormerlo, Luigi, CALABRO', Raffaele, Scrutinio, Domenico, Agostoni, Piergiuseppe, Gesualdo, Loreto, Corra, Ugo, Mezzani, Alessandro, Piepoli, Massimo, Di Lenarda, Andrea, Iorio, Annamaria, Passino, Claudio, Magri, Damiano, Masarone, Daniele, Battaia, Elisa, Girola, Davide, Re, Federica, Cattadori, Gaia, Parati, Gianfranco, Sinagra, Gianfranco, Villani, Giovanni Quinto, Limongelli, Giuseppe, Pacileo, Giuseppe, Guazzi, Marco, Metra, Marco, Frigerio, Maria, Cicoira, Mariantonietta, Miná, Chiara, Malfatto, Gabriella, Caravita, Sergio, Bussotti, Maurizio, Salvioni, Elisabetta, Veglia, Fabrizio, Correale, Michele, Scardovi, Angela B., Emdin, Michele, Giannuzzi, Pantaleo, Gargiulo, Paola, Giovannardi, Marta, Perrone Filardi, Pasquale, Raimondo, Rosa, Ricci, Roberto, Paolillo, Stefania, Farina, Stefania, Belardinelli, Romualdo, Passantino, Andrea, La Gioia, Rocco, Fiorentini, Cesare, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Bertella, Erika, Mantegazza, Valentina, Pietrucci, Francesca, Ferraironi, Aessandro, Casenghi, Matteo, Clemenza, Francesco, Roselli, Teo, Buono, Andrea, Calabro', Raffaele, Santoro, Daniela, Campanale, Saba, Caputo, Domenica, Bertipaglia, Donatella, Vaninetti, Raffaella, Confalonieri, Marco, Zambon, Elena, Berton, Emanuela, Torregiani, Chiara, Cas, Livio Dei, Carubelli, Valentina, Binno, Simone, Marchese, Giovanni, Oliva, Fabrizio, Pastormerlo, Luigi, Corrà, Ugo, Lenarda, Andrea Di, Magrì, Damiano, Minà, Chiara, Scrutinio, D, Agostoni, P, Gesualdo, L, Corra, U, Mezzani, A, Piepoli, M, Di Lenarda, A, Iorio, A, Passino, C, Magri, D, Masarone, D, Battaia, E, Girola, D, Re, F, Cattadori, G, Parati, G, Sinagra, G, Villani, G, Limongelli, G, Pacileo, G, Guazzi, M, Metra, M, Frigerio, M, Cicoira, M, Miná, C, Malfatto, G, Caravita, S, Bussotti, M, Salvioni, E, Veglia, F, Correale, M, Scardovi, A, Emdin, M, Giannuzzi, P, Gargiulo, P, Giovannardi, M, Perrone Filardi, P, Raimondo, R, Ricci, R, Paolillo, S, Farina, S, Belardinelli, R, Passantino, A, La Gioia, R, Fiorentini, C, Apostolo, A, Palermo, P, Contini, M, Bertella, E, Mantegazza, V, Pietrucci, F, Ferraironi, A, Casenghi, M, Clemenza, F, Roselli, T, Buono, A, Calabrò, R, Santoro, D, Campanale, S, Caputo, D, Bertipaglia, D, Vaninetti, R, Confalonieri, M, Zambon, E, Berton, E, Torregiani, C, Cas, L, Carubelli, V, Binno, S, Marchese, G, Oliva, F, Pastormerlo, L, Scardovi, Angela B, and PERRONE FILARDI, Pasquale

Subjects
Adult, Male, medicine.medical_specialty, Kidney Disease, Aged, Chronic Disease, Female, Follow-Up Studies, Humans, Kidney Function Tests, Middle Aged, Exercise, Heart Failure, Kidney Diseases, Oxygen Consumption, Stroke Volume, Prognosi, medicine.medical_treatment, Renal function, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Heart failure, Follow-Up Studie, Peak exercise oxygen consumption, Prognosis, Cardiology and Cardiovascular Medicine, Internal medicine, medicine, Heart transplantation, Ejection fraction, Kidney Function Test, business.industry, Hazard ratio, Atrial fibrillation, General Medicine, Stroke volume, medicine.disease, heart failure, exercise capacity, renal function, exercise capacity, Cardiology, business, Kidney disease, Human
Abstract

Background: Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V˙O2) in heart failure (HF) patients. Methods and Results: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV˙O2 (P

Published
2015

73. Exercise oscillatory ventilation and prognosis in heart failure patients with reduced and mid-range ejection fraction.

Author

Rovai, Sara, Corrà, Ugo, Piepoli, Massimo, Vignati, Carlo, Salvioni, Elisabetta, Bonomi, Alice, Mattavelli, Irene, Arcari, Luca, Scardovi, Angela B., Perrone Filardi, Pasquale, Lagioia, Rocco, Paolillo, Stefania, Magrì, Damiano, Limongelli, Giuseppe, Metra, Marco, Senni, Michele, Scrutinio, Domenico, Raimondo, Rosa, Emdin, Michele, and Lombardi, Carlo

Subjects
HEART failure patients, HEART failure, EXERCISE tests, HEART assist devices, HEART transplantation, EXERCISE
Abstract

Aims: Exercise oscillatory ventilation (EOV) is a pivotal cardiopulmonary exercise test parameter for the prognostic evaluation of patients with chronic heart failure (HF). It has been described in patients with HF with reduced ejection fraction (<40%, HFrEF) and with HF with preserved ejection fraction (>50%, HFpEF), but no data are available for patients with HF with mid-range ejection fraction (40-49%, HFmrEF). The aim of the study was to evaluate the prognostic role of EOV in HFmrEF patients.Methods and Results: We analysed 1239 patients with HFmrEF and 4482 patients with HFrEF, enrolled in the MECKI score database, with a 2-year follow-up. The study endpoint was the composite of cardiovascular death, urgent heart transplant, and ventricular assist device implantation. We identified EOV in 968 cases (16% and 17% of cases in HFmrEF and HFrEF, respectively). HFrEF EOV+ patients were significantly older, and their parameters suggested a more severe HF than HFrEF EOV- patients. A similar behaviour was found in HFmrEF EOV+ vs. EOV- patients. Kaplan-Meier analysis, irrespective of ejection fraction, showed that EOV is associated with a worse survival, and that patients with HFrEF and HFmrEF EOV+ had a significantly worse outcome than the EOV- of the same ejection fraction groups. EOV-associated survival differences in HFmrEF patients started after 18 months of follow-up.Conclusion: Exercise oscillatory ventilation has a similar prevalence and ominous prognostic value in both HFmrEF and HFrEF patients, indicating a group of patients in need of a more intensive follow-up and a more aggressive therapy. In HFmrEF, the survival curves between EOV+ and EOV- patients diverged only after 18 months. [ABSTRACT FROM AUTHOR]

Published
2019
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75. Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction: a long-term comparison

Author

Agostoni, Piergiuseppe, primary, Paolillo, Stefania, additional, Mapelli, Massimo, additional, Gentile, Piero, additional, Salvioni, Elisabetta, additional, Veglia, Fabrizio, additional, Bonomi, Alice, additional, Corrà, Ugo, additional, Lagioia, Rocco, additional, Limongelli, Giuseppe, additional, Sinagra, Gianfranco, additional, Cattadori, Gaia, additional, Scardovi, Angela B., additional, Metra, Marco, additional, Carubelli, Valentina, additional, Scrutinio, Domenico, additional, Raimondo, Rosa, additional, Emdin, Michele, additional, Piepoli, Massimo, additional, Magrì, Damiano, additional, Parati, Gianfranco, additional, Caravita, Sergio, additional, Re, Federica, additional, Cicoira, Mariantonietta, additional, Minà, Chiara, additional, Correale, Michele, additional, Frigerio, Maria, additional, Bussotti, Maurizio, additional, Oliva, Fabrizio, additional, Battaia, Elisa, additional, Belardinelli, Romualdo, additional, Mezzani, Alessandro, additional, Pastormerlo, Luigi, additional, Guazzi, Marco, additional, Badagliacca, Roberto, additional, Di Lenarda, Andrea, additional, Passino, Claudio, additional, Sciomer, Susanna, additional, Zambon, Elena, additional, Pacileo, Giuseppe, additional, Ricci, Roberto, additional, Apostolo, Anna, additional, Palermo, Pietro, additional, Contini, Mauro, additional, Clemenza, Francesco, additional, Marchese, Giovanni, additional, Gargiulo, Paola, additional, Binno, Simone, additional, Lombardi, Carlo, additional, Passantino, Andrea, additional, and Filardi, Pasquale Perrone, additional

Published
2017
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79. La medicina riabilitativa e i criteri di appropriatezza: tra cronicità, multimorbilità e complessità.

Author

Scrutinio, Domenico and Carone, Mauro

Subjects
DISABILITIES, POPULATION aging, REHABILITATION, PEOPLE with disabilities
Abstract

Copyright of Giornale Italiano di Medicina del Lavoro ed Ergonomia is the property of Giornale Italiano di Medicina del Lavoro ed Ergonomia Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

80. Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years.

Author

Paolillo, Stefania, Veglia, Fabrizio, Salvioni, Elisabetta, Corrà, Ugo, Piepoli, Massimo, Lagioia, Rocco, Limongelli, Giuseppe, Sinagra, Gianfranco, Cattadori, Gaia, Scardovi, Angela B., Metra, Marco, Senni, Michele, Bonomi, Alice, Scrutinio, Domenico, Raimondo, Rosa, Emdin, Michele, Magrì, Damiano, Parati, Gianfranco, Re, Federica, and Cicoira, Mariantonietta

Subjects
HEART assist devices, HEART failure, OXYGEN consumption, HEART, COMPARATIVE studies, EXERCISE tests, FORECASTING, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, RESEARCH, RESPIRATION, PULMONARY function tests, EVALUATION research, RETROSPECTIVE studies, RECEIVER operating characteristic curves, DISEASE progression
Abstract

Aims: Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 years in parallel with HF prognosis improvement.Methods and Results: Data from 6083 HF patients (81% male, age 61 ± 13 years), enrolled in the MECKI score database between 1993 and 2015, were retrospectively analysed. By enrolment year, four groups were generated: group 1 1993-2000 (n = 440), group 2 2001-2005 (n = 1288), group 3 2006-2010 (n = 2368), and group 4 2011-2015 (n = 1987). We compared the 10-year survival of groups and analysed how the overall risk (cardiovascular death, urgent heart transplantation, or left ventricular assist device implantation) changed over time according to peak VO2 and VE/VCO2 slope and to major clinical and therapeutic variables. At 10 years, a progressively higher survival from group 1 to group 3 was observed, with no further improvement afterwards. A 20% risk for peak VO2 15 mL/min/kg (95% confidence interval 16-13), 9 (11-8), 4 (4-2) and 5 (7-4) was observed in group 1, 2, 3, and 4, respectively, while the VE/VCO2 slope value for a 20% risk was 32 (37-29), 47 (51-43), 59 (64-55), and 57 (63-52), respectively.Conclusions: Heart failure prognosis improved over time up to 2010 in a HF population followed by experienced centres. The peak VO2 and VE/VCO2 slope cut-offs identifying a definite risk progressively decreased and increased over time, respectively. The prognostic threshold of peak VO2 and VE/VCO2 slope must be updated whenever HF prognosis improves. [ABSTRACT FROM AUTHOR]

Published
2019
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81. Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

Author

Ciccone, Marco, Scicchitano,Pietro, Cortese,Francesca, Ricci,Gabriella, Carbonara,Santa, Moncelli,Michele, Iacoviello,Massimo, Cecere,Annagrazia, Gesualdo,Michele, Zito,Annapaola, Caldarola,Pasquale, Lagioia,Rocco, Riccioni,Graziano, and Scrutinio,Domenico

Subjects
Drug Design, Development and Therapy
Abstract

Pietro Scicchitano,1 Francesca Cortese,1 Gabriella Ricci,1 Santa Carbonara,1 Michele Moncelli,1 Massimo Iacoviello,1 Annagrazia Cecere,1 Michele Gesualdo,1 Annapaola Zito,1 Pasquale Caldarola,2 Domenico Scrutinio,3 Rocco Lagioia,3 Graziano Riccioni,4 Marco Matteo Ciccone1 1Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy; 2Section of Cardiovascular Diseases, Policlinic, San Paolo Hospital, Bari, Italy; 3Section of Cardiovascular Diseases, Fondazione Maugeri, Cassano Murge, Italy; 4Intensive Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy Abstract: Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce heart rate and ameliorate the cardiovascular risk profile of individuals, especially those suffering from coronary artery diseases (CAD) and chronic heart failure (CHF). Ivabradine is the first pure heart rate reductive drug approved and currently used in humans, created in order to selectively reduce sinus node function and to overcome the many side effects of similar pharmacological tools (ie, β-blockers or calcium channel antagonists). The aim of our review is to evaluate the role and the safety of this molecule on CAD and CHF therapeutic strategies. Keywords: chronic heart failure, heart rate reduction, cardiac ischemic disease, heart-rate lowering drugs, funny current

Published
2014

82. Severe heart failure prognosis evaluation for transplant selection in the era of beta-blockers: Role of peak oxygen consumption

Author

Cattadori, Gaia, Agostoni, Piergiuseppe, Corrà, Ugo, Di Lenarda, Andrea, Sinagra, Gianfranco, Veglia, Fabrizio, Salvioni, Elisabetta, La Gioia, Rocco, Scardovi, Angela B., Emdin, Michele, Metra, Marco, Limongelli, Giuseppe, Raimondo, Rosa, Re, Federica, Guazzi, Marco, Belardinelli, Romualdo, Parati, Gianfranco, Magrì, Damiano, Fiorentini, Cesare, Mezzani, Alessandro, Scrutinio, Domenico, Pacileo, Giuseppe, Apostolo, Anna, Iorio, AnnaMaria, Paolillo, Stefania, Palermo, Pietro, Contini, Mauro, Giannuzzi, Pantaleo, Battaia, Elisa, Cicoira, Mariantonietta, Passino, Claudio, and Piepoli, Massimo F.

Published
2013
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85. Mutational Spectrum of CYP24A1 Gene in a Cohort of Italian Patients with Idiopathic Infantile Hypercalcemia

Author

Gigante, Maddalena, primary, Santangelo, Luisa, additional, Diella, Sterpeta, additional, Caridi, Gianluca, additional, Argentiero, Lucia, additional, D''Alessandro, Maria Michela, additional, Martino, Marida, additional, Stea, Emma Diletta, additional, Ardissino, Gianluigi, additional, Carbone, Vincenza, additional, Pepe, Silvana, additional, Scrutinio, Domenico, additional, Maringhini, Silvio, additional, Ghiggeri, Gian Marco, additional, Grandaliano, Giuseppe, additional, Giordano, Mario, additional, and Gesualdo, Loreto, additional

Published
2016
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86. Prognostic role of atrial fibrillation in patients affected by chronic heart failure. Data from the MECKI score research group

Author

Paolillo, Stefania, primary, Agostoni, Piergiuseppe, additional, Masarone, Daniele, additional, Corrà, Ugo, additional, Passino, Claudio, additional, Scrutinio, Domenico, additional, Correale, Michele, additional, Cattadori, Gaia, additional, Metra, Marco, additional, Girola, Davide, additional, Piepoli, Massimo F., additional, Salvioni, Elisabetta, additional, Giovannardi, Marta, additional, Iorio, Annamaria, additional, Emdin, Michele, additional, Raimondo, Rosa, additional, Re, Federica, additional, Cicoira, Mariantonietta, additional, Belardinelli, Romualdo, additional, Guazzi, Marco, additional, Clemenza, Francesco, additional, Parati, Gianfranco, additional, Scardovi, Angela B., additional, Di Lenarda, Andrea, additional, La Gioia, Rocco, additional, Frigerio, Maria, additional, Lombardi, Carlo, additional, Gargiulo, Paola, additional, Sinagra, Gianfranco, additional, Pacileo, Giuseppe, additional, Perrone-Filardi, Pasquale, additional, and Limongelli, Giuseppe, additional

Published
2015
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87. Predicting Short-Term Mortality in Advanced Decompensated Heart Failure – Role of the Updated Acute Decompensated Heart Failure/N-Terminal Pro-B-Type Natriuretic Peptide Risk Score –

Author

Scrutinio, Domenico, primary, Ammirati, Enrico, additional, Passantino, Andrea, additional, Guida, Pietro, additional, D’Angelo, Luciana, additional, Oliva, Fabrizio, additional, Ciccone, Marco Matteo, additional, Iacoviello, Massimo, additional, Dentamaro, Ilaria, additional, Santoro, Daniela, additional, Lagioia, Rocco, additional, Sarzi Braga, Simona, additional, Guzzetti, Daniela, additional, and Frigerio, Maria, additional

Published
2015
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88. Ivabradine, coronary artery disease, and heart failure: beyond rhythm control

Author

Scicchitano,Pietro, Cortese,Francesca, Ricci,Gabriella, Carbonara,Santa, Moncelli,Michele, Iacoviello,Massimo, Cecere,Annagrazia, Gesualdo,Michele, Zito,Annapaola, Caldarola,Pasquale, Scrutinio,Domenico, Lagioia,Rocco, Riccioni,Graziano, Ciccone,Marco Matteo, Scicchitano,Pietro, Cortese,Francesca, Ricci,Gabriella, Carbonara,Santa, Moncelli,Michele, Iacoviello,Massimo, Cecere,Annagrazia, Gesualdo,Michele, Zito,Annapaola, Caldarola,Pasquale, Scrutinio,Domenico, Lagioia,Rocco, Riccioni,Graziano, and Ciccone,Marco Matteo

Abstract

Pietro Scicchitano,1 Francesca Cortese,1 Gabriella Ricci,1 Santa Carbonara,1 Michele Moncelli,1 Massimo Iacoviello,1 Annagrazia Cecere,1 Michele Gesualdo,1 Annapaola Zito,1 Pasquale Caldarola,2 Domenico Scrutinio,3 Rocco Lagioia,3 Graziano Riccioni,4 Marco Matteo Ciccone1 1Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy; 2Section of Cardiovascular Diseases, Policlinic, San Paolo Hospital, Bari, Italy; 3Section of Cardiovascular Diseases, Fondazione Maugeri, Cassano Murge, Italy; 4Intensive Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy Abstract: Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce heart rate and ameliorate the cardiovascular risk profile of individuals, especially those suffering from coronary artery diseases (CAD) and chronic heart failure (CHF). Ivabradine is the first pure heart rate reductive drug approved and currently used in humans, created in order to selectively reduce sinus node function and to overcome the many side effects of similar pharmacological tools (ie, β-blockers or calcium channel antagonists). The aim of our review is to evaluate the role and the safety of this molecule on CAD and CHF therapeutic strategies. Keywords: chronic heart failure, heart rate reduction, cardiac ischemic disease, heart-rate lowering drugs, funny current

Published
2014

89. Predictors of Long-Term Mortality in Older Patients Hospitalized for Acutely Decompensated Heart Failure: Clinical Relevance of Natriuretic Peptides.

Author

Passantino, Andrea, Guida, Piero, Lagioia, Rocco, Ammirati, Enrico, Oliva, Fabrizio, Frigerio, Maria, and Scrutinio, Domenico

Subjects
MORTALITY risk factors, HOSPITAL care of older people, RETROSPECTIVE studies, HEART failure, HOSPITALS, MEDICAL cooperation, PEPTIDE hormones, REFERENCE values, RESEARCH, RISK assessment, COMORBIDITY, DESCRIPTIVE statistics, VENTRICULAR ejection fraction, PROGNOSIS
Abstract

Background Acute heart failure is a common cause of hospitalization among older patients. Optimized risk stratification might improve the outcome for this subgroup of patients. Natriuretic peptides have been used in the diagnosis of heart failure and in evaluating the prognosis of patients hospitalized for heart failure. However, their utility in the elderly is still controversial. Objective To evaluate long-term survival and prognostic factors for elderly patients hospitalized for acutely decompensated heart failure and evaluate the prognostic utility of NT-proBNP. Design Retrospective, multicenter cohort study. Setting Two Italian hospitals. Participants Two hundred seventy-nine patients, aged >75 years; hospitalized for decompensation of chronic, established heart failure. Methods Baseline clinical data were recorded at admission. The primary outcome was long-term mortality. Results In-hospital, 12-month and 5-year mortality were, respectively, 10%, 36%, and 77%. NT-proBNP, eGFR, hemoglobin, diabetes, systolic blood pressure, and moderate to severe tricuspid regurgitation were independently associated with long-term prognosis and were entered into a multivariate model, with a C-index of 0.765 for the determination of high-risk patients. The C-index for NT-proBNP to predict mortality at 2 and 12 months was 0.740 and 0.756, respectively. The optimal cutoff point for predicting mortality at 2 and 12 months was 8,444 pg/mL (hazard ratio 5.33) and 8,275 pg/mL (hazard ratio 6.03), respectively. Conclusion Elderly patients hospitalized for acutely decompensated heart failure had a poor long-term outcome, especially in the subgroup with reduced ejection fraction (EF). In addition to EF and comorbidities, NT-pro-BNP remained independently prognostic among elderly patients hospitalized with heart failure. [ABSTRACT FROM AUTHOR]

Published
2017
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90. Deceptive meaning of oxygen uptake measured at the anaerobic threshold in patients with systolic heart failure and atrial fibrillation

Author

Magrì, Damiano, primary, Agostoni, Piergiuseppe, additional, Corrà, Ugo, additional, Passino, Claudio, additional, Scrutinio, Domenico, additional, Perrone-Filardi, Pasquale, additional, Correale, Michele, additional, Cattadori, Gaia, additional, Metra, Marco, additional, Girola, Davide, additional, Piepoli, Massimo F, additional, Iorio, AnnaMaria, additional, Emdin, Michele, additional, Raimondo, Rosa, additional, Re, Federica, additional, Cicoira, Mariantonietta, additional, Belardinelli, Romualdo, additional, Guazzi, Marco, additional, Limongelli, Giuseppe, additional, Clemenza, Francesco, additional, Parati, Gianfranco, additional, Frigerio, Maria, additional, Casenghi, Matteo, additional, Scardovi, Angela B, additional, Ferraironi, Alessandro, additional, Di Lenarda, Andrea, additional, Bussotti, Maurizio, additional, Apostolo, Anna, additional, Paolillo, Stefania, additional, La Gioia, Rocco, additional, Gargiulo, Paola, additional, Palermo, Pietro, additional, Minà, Chiara, additional, Farina, Stefania, additional, Battaia, Elisa, additional, Maruotti, Antonello, additional, Pacileo, Giuseppe, additional, Contini, Mauro, additional, Oliva, Fabrizio, additional, Ricci, Roberto, additional, and Sinagra, Gianfranco, additional

Published
2014
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93. Prognostic Value of Indeterminable Anaerobic Threshold in Heart Failure

Author

Agostoni, Piergiuseppe, primary, Corrà, Ugo, additional, Cattadori, Gaia, additional, Veglia, Fabrizio, additional, Battaia, Elisa, additional, La Gioia, Rocco, additional, Scardovi, Angela B., additional, Emdin, Michele, additional, Metra, Marco, additional, Sinagra, Gianfranco, additional, Limongelli, Giuseppe, additional, Raimondo, Rosa, additional, Re, Federica, additional, Guazzi, Marco, additional, Belardinelli, Romualdo, additional, Parati, Gianfranco, additional, Magrì, Damiano, additional, Fiorentini, Cesare, additional, Cicoira, Mariantonietta, additional, Salvioni, Elisabetta, additional, Giovannardi, Marta, additional, Mezzani, Alessandro, additional, Scrutinio, Domenico, additional, Di Lenarda, Andrea, additional, Mantegazza, Valentina, additional, Ricci, Roberto, additional, Apostolo, Anna, additional, Iorio, AnnaMaria, additional, Paolillo, Stefania, additional, Palermo, Pietro, additional, Contini, Mauro, additional, Vassanelli, Corrado, additional, Passino, Claudio, additional, and Piepoli, Massimo F., additional

Published
2013
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94. Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: A multiparametric approach to heart failure prognosis

Author

Agostoni, Piergiuseppe, primary, Corrà, Ugo, additional, Cattadori, Gaia, additional, Veglia, Fabrizio, additional, La Gioia, Rocco, additional, Scardovi, Angela B., additional, Emdin, Michele, additional, Metra, Marco, additional, Sinagra, Gianfranco, additional, Limongelli, Giuseppe, additional, Raimondo, Rossella, additional, Re, Federica, additional, Guazzi, Marco, additional, Belardinelli, Romualdo, additional, Parati, Gianfranco, additional, Magrì, Damiano, additional, Fiorentini, Cesare, additional, Mezzani, Alessandro, additional, Salvioni, Elisabetta, additional, Scrutinio, Domenico, additional, Ricci, Renato, additional, Bettari, Luca, additional, Di Lenarda, Andrea, additional, Pastormerlo, Luigi E., additional, Pacileo, Giuseppe, additional, Vaninetti, Raffaella, additional, Apostolo, Anna, additional, Iorio, AnnaMaria, additional, Paolillo, Stefania, additional, Palermo, Pietro, additional, Contini, Mauro, additional, Confalonieri, Marco, additional, Giannuzzi, Pantaleo, additional, Passantino, Andrea, additional, Cas, Livio Dei, additional, Piepoli, Massimo F., additional, and Passino, Claudio, additional

Published
2013
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98. Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Author

Ciccone, Marco Matteo, primary, Cicinelli, Ettore, additional, Giovanni, Alessio, additional, Scicchitano, Pietro, additional, Gesualdo, Michele, additional, Zito, Annapaola, additional, Fornarelli, Fara, additional, Locorotondo, Manuela, additional, Cicinelli, Maria Vittoria, additional, Teo, Concetta Di, additional, Farinola, Giuseppe, additional, and Scrutinio, Domenico, additional

Published
2012
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