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52. Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation

Author

Silbernagel, Günther, primary, Chen, Yan Q, additional, Rief, Martin, additional, Kleber, Marcus E, additional, Hoffmann, Michael M, additional, Stojakovic, Tatjana, additional, Stang, Andreas, additional, Sarzynski, Mark A, additional, Bouchard, Claude, additional, März, Winfried, additional, Qian, Yue-Wei, additional, Scharnagl, Hubert, additional, and Konrad, Robert J, additional

Published
2023
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53. Abstract 679: HDL Apolipoproteomic Score, Cardiometabolic Risk, And Exercise Training

Author

Miranda Maravi, Juan S, primary, Schwartz, Charles S, additional, Dev, Prasun K, additional, Barber, Jacob L, additional, Reasons, Riley J, additional, Pearce, Ryan W, additional, Mcphaul, Michael J, additional, Gerszten, Robert E, additional, Rohatgi, Anand, additional, Bouchard, Claude, additional, Collier, Timothy S, additional, and Sarzynski, Mark A, additional

Published
2023
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56. Author Correction: Human plasma proteomic profiles indicative of cardiorespiratory fitness

Author

Robbins, Jeremy M., Peterson, Bennet, Schranner, Daniela, Tahir, Usman A., Rienmüller, Theresa, Deng, Shuliang, Keyes, Michelle J., Katz, Daniel H., Beltran, Pierre M. Jean, Barber, Jacob L., Baumgartner, Christian, Carr, Steven A., Ghosh, Sujoy, Shen, Changyu, Jennings, Lori L., Ross, Robert, Sarzynski, Mark A., Bouchard, Claude, and Gerszten, Robert E.

Published
2021
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64. Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations

Author

Robbins, Jeremy M., primary, Rao, Prashant, additional, Deng, Shuliang, additional, Keyes, Michelle J., additional, Tahir, Usman A., additional, Katz, Daniel H., additional, Beltran, Pierre M. Jean, additional, Marchildon, François, additional, Barber, Jacob L., additional, Peterson, Bennet, additional, Gao, Yan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Smith, J. Gustav, additional, Cohen, Paul, additional, Ross, Robert, additional, Bouchard, Claude, additional, Sarzynski, Mark A., additional, and Gerszten, Robert E., additional

Published
2023
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65. Abstract P201: Plasma Proteomic Signatures of Angptl3/8 and 4/8 Before and After Exercise Training

Author

Miranda-Maravi, Sebastian, primary, Hoffman, William G, additional, Dev, Prasun K, additional, Barber, Jacob L, additional, Schwartz, Charles S, additional, Clarkson, William A, additional, Robbins, Jeremy M, additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Silbernagel, Gunther, additional, Chen, Yan Q, additional, Konrad, Robert J, additional, Bouchard, Claude, additional, Gerszten, Robert E, additional, and Sarzynski, Mark A, additional

Published
2023
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66. Abstract P205: Association of Angptl3/8 and 4/8 With Plasma Metabolites Before and After Exercise Training

Author

Dev, Prasun K, primary, Miranda-Maravi, Sebastian, additional, Hoffman, William, additional, Barber, Jacob L, additional, Schwartz, Charles S, additional, Clarkson, William A, additional, Robbins, Jeremy M, additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Silbernagel, Gunther, additional, Chen, Yan Q, additional, Konrad, Robert J, additional, Bouchard, Claude, additional, Gerszten, Robert E, additional, and Sarzynski, Mark A, additional

Published
2023
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67. Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis

Author

Cronjé, Héléne T., primary, Mi, Michael Y., primary, Austin, Thomas R., primary, Biggs, Mary L., primary, Siscovick, David S., primary, Lemaitre, Rozenn N., primary, Psaty, Bruce M., primary, Tracy, Russell P., primary, Djoussé, Luc, primary, Kizer, Jorge R., primary, Ix, Joachim H., primary, Rao, Prashant, primary, Robbins, Jeremy M., primary, Barber, Jacob L., primary, Sarzynski, Mark A., primary, Clish, Clary B., primary, Bouchard, Claude, primary, Mukamal, Kenneth J., primary, Gerszten, Robert E., primary, and Jensen, Majken K., primary

Published
2023
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71. PWC150_Supplemental Tables 1-13.xlsx

Author

Sarzynski, Sarzynski, Mark A., Bouchard, Claude, and Ghosh, Sujoy

Abstract

Supplemental tables for PWC150 manuscript titled "Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability" for Physiological Genomics

Published
2023
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75. Effect of individual characteristics and aerobic training on the %HRR-%V̇O2R relationship.

Author

Ferri Marini, Carlo, Sisti, Davide, Skinner, James S., Sarzynski, Mark A., Bouchard, Claude, Amatori, Stefano, Rocchi, Marco B. L., Piccoli, Giovanni, Stocchi, Vilberto, Federici, Ario, and Lucertini, Francesco

Subjects
EXERCISE tests, STATISTICS, AEROBIC exercises, OXYGEN consumption, MULTIPLE regression analysis, EXERCISE physiology, REGRESSION analysis, T-test (Statistics), EXERCISE intensity, HEART beat, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis
Abstract

This study aimed to assess if, during incremental exercise, considering individual characteristics can make the relationship between the percentages of heart rate (HRR) and oxygen uptake (V̇O2R) reserve either 1:1 or more accurate. Cycle ergometer data of the maximal incremental exercise tests performed by 450 healthy and sedentary participants (17-66 years) of the HERITAGE Family Study, grouped for sex, ethnicity, age, body fat, resting HR, and V̇O2max, were used to calculate the individual linear regressions between %HRR and %V̇O2R. The mean slope and intercept of the individual linear regressions of each subgroup were compared with 1 and 0 (identity line), respectively, using Hotelling tests followed by post-hoc one-sample t-tests. Two multiple linear regressions were also performed, using either the slopes or intercepts of the individual linear regressions as dependent variables and sex, age, resting HR, and V̇O2max as independent variables. The mean %HRR-%V̇O2R relationships of all subgroups differed from the identity line. Moreover, individual linear regression intercepts (8.9 ± 16.0) and slopes (0.971 ± 0.190) changed (p < 0.001) after 20 weeks of aerobic training (13.1 ± 11.1 and 0.891 ± 0.122). The multiple linear regressions could explain only 3.8% and 1.3% of the variance in the intercepts and slopes, whose variability remained high (standard error of estimate of 15.8 and 0.189). In conclusion, the %HRR-%V̇O2R relationship differs from the identity line regardless of individual characteristics and their difference increased after aerobic training. Moreover, due to the high interindividual variability, using a single equation for the whole population seems not suitable for representing the %HRR-%V̇O2R relationship of a given subject, even when several individual characteristics are considered. Highlights The association between %HRR and %V̇O2R is not 1:1 even when individuals are grouped by age, sex, ethnicity, body composition, HRrest, and V̇O2max. Using several subject characteristics to identify the individual's %HRR-%V̇O2R relationship does not meaningfully increase its prediction accuracy or reduce the interindividual variability of %HRR-%V̇O2R relationships Using a single equation for the whole population is not suitable for representing the relationship of a given subject; hence, individual relationships should be preferred when prescribing the intensity of aerobic exercise. The individual %HRR-%V̇O2R relationship should be periodically assessed due to the potential training induced changes in the relationship. [ABSTRACT FROM AUTHOR]

Published
2023
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79. EXERCISE TRAINING SLOWS DOWN PROTEOMIC AGE ACCELERATION IN MIDDLE-AGED TO OLDER ADULTS- HERITAGE FAMILY STUDY

Author

Dev, Prasun K., primary, Barbar, Jacob L., additional, Cai, Guoshuai, additional, Robbins, Jeremy M., additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Katz, Daniel H., additional, Gerszten, Robert E., additional, Bouchard, Claude, additional, and Sarzynski, Mark A., additional

Published
2022
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81. Associations Between Changes In Plasma Proteins And Body Composition Traits In Response To Endurance Training

Author

Clarkson, William A., primary, Barber, Jacob L., additional, Robbins, Jeremy M., additional, Rao, Prashant, additional, Mi, Michael, additional, Dev, Prasun K., additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Katz, Daniel H., additional, Gerszten, Robert E., additional, Bouchard, Claude, additional, and Sarzynski, Mark A., additional

Published
2022
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83. Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

Author

Katz, Daniel H., primary, Robbins, Jeremy M., additional, Deng, Shuliang, additional, Tahir, Usman A., additional, Bick, Alexander G., additional, Pampana, Akhil, additional, Yu, Zhi, additional, Ngo, Debby, additional, Benson, Mark D., additional, Chen, Zsu-Zsu, additional, Cruz, Daniel E., additional, Shen, Dongxiao, additional, Gao, Yan, additional, Bouchard, Claude, additional, Sarzynski, Mark A., additional, Correa, Adolfo, additional, Natarajan, Pradeep, additional, Wilson, James G., additional, and Gerszten, Robert E., additional

Published
2022
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88. Plasma Proteomic Risk Markers of Incident Type 2 Diabetes Reflect Physiologically Distinct Components of Glucose-Insulin Homeostasis.

Author

Cronjé, Héléne T., Mi, Michael Y., Austin, Thomas R., Biggs, Mary L., Siscovick, David S., Lemaitre, Rozenn N., Psaty, Bruce M., Tracy, Russell P., Djoussé, Luc, Kizer, Jorge R., Ix, Joachim H., Rao, Prashant, Robbins, Jeremy M., Barber, Jacob L., Sarzynski, Mark A., Clish, Clary B., Bouchard, Claude, Mukamal, Kenneth J., Gerszten, Robert E., and Jensen, Majken K.

Subjects
TYPE 2 diabetes, PROTEOMICS, BLOOD proteins, HOMEOSTASIS, GLUCOSE tolerance tests
Abstract

High-throughput proteomics allows researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic responses to an intravenous glucose tolerance test (IVGTT) to identify novel protein contributors to glucose homeostasis and diabetes risk. We tested 4,776 SomaScan proteins measured in relation to 18-year incident diabetes risk in participants from the Cardiovascular Health Study (N = 2,631) and IVGTT-derived measures in participants from the HERITAGE Family Study (N = 752). We characterize 51 proteins that were associated with longitudinal diabetes risk, using their respective 39, 9, and 8 concurrent associations with insulin sensitivity index (SI), acute insulin response to glucose (AIRG), and glucose effectiveness (SG). Twelve of the 51 diabetes associations appear to be novel, including β-glucuronidase, which was associated with increased diabetes risk and lower SG, suggesting an alternative pathway to insulin for glucose disposal; and plexin-B2, which also was associated with increased diabetes risk, but with lower AIRG, and not with SI, indicating a mechanism related instead to pancreatic dysfunction. Other novel protein associations included alcohol dehydrogenase-1C, fructose-bisphosphate aldolase-B, sorbitol dehydrogenase with elevated type 2 diabetes risk, and a leucine-rich repeat containing protein-15 and myocilin with decreased risk. Article Highlights: Plasma proteins are associated with the risk of incident diabetes in older adults independent of various demographic, lifestyle, and biochemical risk factors. These same proteins are associated with subtle differences in measures of glucose homeostasis earlier in life. Proteins that are associated with lower insulin sensitivity in individuals without diabetes tend to be associated with appropriate compensatory mechanisms, such as a stronger acute insulin response or higher glucose effectiveness. Proteins that are associated with future diabetes risk, but not with insulin insensitivity, tend to be associated with lower glucose effectiveness and/or impaired acute insulin response. [ABSTRACT FROM AUTHOR]

Published
2023
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90. The Association of Cardiorespiratory Fitness and Ideal Cardiovascular Health in the Aerobics Center Longitudinal Study.

Author

Ross, Leanna M., Barber, Jacob L., McLain, Alexander C., Weaver, R. Glenn, Xuemei Sui, Blair, Steven N., and Sarzynski, Mark A.

Subjects
CARDIOPULMONARY system, PHYSICAL activity, EPIDEMIOLOGY, PUBLIC health, CONFIDENCE intervals
Abstract

Background: This study examined the cross-sectional and longitudinal associations of cardiorespiratory fitness (CRF) and ideal cardiovascular health (CVH). Methods: CRF and the 7 CVH components were measured in 11,590 (8865 males; 2725 females) adults at baseline and in 2532 (2160 males; 372 females) adults with at least one follow-up examination from the Aerobics Center Longitudinal Study. Ideal CVH score was calculated as a composite of 7 measures, each scored 0 to 2. CVH groups were based on participant point score: ≤7 (poor), 8 to 11 (intermediate), and 12 to 14 (ideal). Analyses included general linear, logistic regression, and linear mixed models. Results: At baseline, participants in the high CRF category had 21% and 45% higher mean CVH scores than those in the moderate and poor CRF categories (P < .001). The adjusted odds (95% confidence interval) of being in the poor CVH group at baseline were 4.9 (4.4-5.4) and 16.9 (14.3-19.9) times greater for individuals with moderate and low CRF, respectively, compared with those with high CRF (P < .001). Longitudinal analysis found that for every 1-minute increase in treadmill time, CVH score increased by 0.23 units (P < .001) independent of age, sex, exam number, and exam year. Conclusions: Higher CRF is associated with better CVH profiles, and improving CRF over time is independently associated with greater improvements in CVH. [ABSTRACT FROM AUTHOR]

Published
2019
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91. Abstract P175: Combined Metabolic Health And Obesity Status Is Associated With Markers Of High-Density Lipoprotein Metabolism: Dallas Heart Study

Author

Clarkson, William A, primary, Barber, Jacob L, additional, Armstrong, Bridget, additional, Wang, Yuan, additional, McGillicuddy, Fiona C, additional, Saldanha, Suzanne, additional, Akinmolayemi, Oludamilola, additional, Neeland, Ian J, additional, Rohatgi, Anand, additional, and Sarzynski, Mark A, additional

Published
2022
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93. Abstract P204: Association Of Plasma Proteome With Inflammatory Markers Crp And Glyca And Their Responses To Exercise Training

Author

Barber, Jacob, primary, Cai, Guoshuai, additional, Dev, Prasun K, additional, Robbins, Jeremy M, additional, Rao, Prashant, additional, Mi, Michael, additional, Ghosh, Sujoy, additional, Clish, Clary, additional, Katz, Daniel H, additional, Gerszten, Robert E, additional, Bouchard, Claude, additional, and Sarzynski, Mark A, additional

Published
2022
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94. Abstract P038: Association Of Discordance Between Low-density Lipoprotein And High-density Lipoprotein Cholesterol Versus Particle Concentration With Incidence Of Type 2 Diabetes: Coronary Artery Risk Development In Young Adults Study

Author

Ruiz-Ramie, Jonathan J, primary, Barber, Jacob, additional, Wang, Xuewen, additional, Wilkins, John T, additional, Snell-bergeon, Janet, additional, Lloyd-Jones, Don M, additional, Lane-cordova, Abbi, additional, and Sarzynski, Mark A, additional

Published
2022
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96. Alterations in Glycemic Variability, Vascular Health, and Oxidative Stress following a 12-Week Aerobic Exercise Intervention-A Pilot Study

Author

SPARKS, JOSHUA R., SARZYNSKI, MARK A., DAVIS, J. MARK, GRANDJEAN, PETER W., and WANG, XUEWEN

Subjects
Original Research
Abstract

The state of being overweight or obese leads to an increased risk of development of cardiometabolic disease. Increases in glycemic variability have been associated with greater induction of oxidative stress and declined vascular health, which may be exacerbated by higher weight status and improved through exercise. The purpose of this study was to examine the impact of a twelve-week aerobic exercise intervention on continuous glucose monitor (CGM) assessed glucose concentrations and glycemic variability, and biomarkers of vascular health and oxidative stress in overweight or obese adults. Eight adults (Age = 48.9 ± 5.2 years; BMI = 29.4 ± 8.3 kg/m2) completed a twelve-week aerobic exercise intervention. Participants walked three times per week at moderate intensity for ~150 minutes each week. All participants wore a CGM for seven consecutive days at baseline and post-intervention. On the final day of monitoring, a fasting blood sample was collected, and an oral glucose tolerance test (OGTT) was performed. Intra- and inter-day glycemic variability was assessed as the mean amplitude of glycemic excursions, continuous overlapping net glycemic action of one-, two-, and four-hour, and the mean observation of daily differences. Plasma concentrations of nitric oxide (NO) and myeloperoxidase (MPO) were measured, and their ratio was calculated (NO:MPO). No CGM-assessed glucose concentrations or measures of glycemic variability changed from baseline to post-intervention. MPO concentration decreased (24.8 ± 8.2 ng/mL to 16.4 ± 4.6 ng/mL, p < 0.01), the NO:MPO ratio improved (3.5:1 to 6.4:1, p < 0.01) following the twelve-week intervention. Individual level changes in body weight and V̇O(2)peak were found. In conclusion, twelve weeks of aerobic exercise reduced oxidative stress and improved the propensity to vasodilate but did not alter CGM-assessed glucose concentrations or glycemic variability in this group of overweight or obese non-diabetic adults. These findings may be due to individual changes in body weight or V̇O2peak, which necessitates further research to explore their influence on these outcomes of interest.

Published
2021

100. Abstract 14285: Plasma Proteomic Profiling of Endurance Exercise Identifies Changes in Extracellular Matrix Biology Associated With Adaptations in Maximal Oxygen Uptake

Author

Robbins, Jeremy, primary, Rao, Prashant, additional, Mi, Michael, additional, Keyes, Michelle, additional, Deng, Shuliang, additional, Katz, Daniel H, additional, Jean Beltran, Pierre M, additional, Tahir, Usman A, additional, Barber, Jacob, additional, Farrell, Laurie, additional, Clish, Clary, additional, Sarzynski, Mark A, additional, Bouchard, Claude, additional, and Gerszten, Robert E, additional

Published
2021
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