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53. A recombined fusion protein SP5.2/tTF induce thrombosis in tumor blood vessel

Author

S Lv, X Luo, M Ye, X Li, F Zeng, L Luo, J Yan, Y Dai, X Chen, C Wang, X Wang, K Li, Z Li, and X Dou

Subjects
endocrine system, Cancer Research, Expression vector, respiratory system, Fusion protein, Molecular biology, Umbilical vein, law.invention, Fusion gene, chemistry.chemical_compound, Tissue factor, Oncology, chemistry, law, Recombinant DNA, Growth inhibition, Chromatography column
Abstract

Tumor vascular targeting is one of the most promising strategies in tumor therapy. Here we used E.coli to express a recombinant SP5.2/tTF fusion protein, which, as a tumor vascular targeting agent, consists of SP5.2 (a peptide selectively binding and targeting VEGFR-1 on tumor endothelial cells) and truncated tissue factor (tTF)and aimed to explore its anti-tumor activities.The SP5.2/tTF expression construct was synthesized by polymerase chain reaction (PCR) and recombined into plasmid pET22b(+). The fusion gene was verified by restriction mapping and sequencing. SP5.2/tTF was expressed in E. coli and then purified on a nickel-affinity chromatography column. The purified product was detected by SDS-PAGE. The pro-coagulant activity and binding of SP5.2/tTF to human umbilical vein endothelial cells (HUVECs) were monitored by FX activation analysis and fluorescent scanning confocal microscopy, respectively. The effect of SP5.2/tTF on tumor growth was analyzed in BALB/c mice bearing sarcoma 180 (S180) tumor. The tissue localization of SP5.2/tTF and its effect on tumor vessel thrombosis were observed by in vivo fluorescence imaging and histological studies, respectively. The fusion gene was successfully cloned into pET22b(+). SP5.2/tTF was abundantly expressed in bacterial cells and efficiently purified by nickel-affinity chromatography. Functional studies showed that the protein retained both the coagulation activity of tTF and the binding capacity of SP5.2 to HUVECs. In tumor xenograft studies, SP5.2/tTF selectively targeted the tumor, induced thrombosis, and led to retardation and even regression of tumor growth (growth inhibition ratio = 70%, P< 0.05). The recombinant fusion protein SP5.2/tTF inhibited tumor growth by selectively inducing thrombosis in tumor blood vessels.

Published
2015

54. Application of manganese dioxide to electromagnetic wave absorber: effective permittivity and absorbing property

Author

S. Lv, Y. Zhao, Hongtao Guan, and S. Liu

Subjects
Permittivity, Materials science, Mixing (process engineering), Mineralogy, chemistry.chemical_element, Manganese, Dielectric, Condensed Matter Physics, Electromagnetic radiation, Electronic, Optical and Magnetic Materials, Condensed Matter::Materials Science, symbols.namesake, Volume (thermodynamics), chemistry, symbols, Condensed Matter::Strongly Correlated Electrons, Composite material, Rayleigh scattering, Instrumentation, High-κ dielectric
Abstract

This paper presents the application of manganese dioxide to electromagnetic wave absorber. The effective permittivity was calculated by modified Rayleigh mixing formula, and the electromagnetic wave absorbing properties of composites with different volume fractions of manganese dioxide were investigated by the comparison of calculated and experimental values in 2–12 GHz frequencies. It is found that the pure manganese dioxide holds a high dielectric constant, which is a function of frequency. The manganese dioxide composites show high absorbing performance in low frequencies, and the calculated electromagnetic properties fit the experimental values for large volume fractions used in this study.

Published
2006
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57. Precision Measurement of the Helium Flux in Primary Cosmic Rays of Rigidities 1.9 GV to 3 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author

N. Nikonov, Corrado Gargiulo, A. Egorov, I. Cernuda, Carlos Díaz, W. De Boer, Corinne Goy, Wei Sun, Haifeng Li, P. Vialle, E. Fiandrini, H. S. Chen, Zhiqi Huang, Xiaoqun Wang, I. Gebauer, C. Türkoğlu, Arturo Alejandro Menchaca-Rocha, S. Krafczyk, L. Tao, S. Xie, J. Q. Ni, Fabrizio Giulio Luca Pilo, F. Spinella, S. S. Lv, Maria Ionica, S. Chen, Markus Battarbee, J. Gong, J. Sandweiss, H. Y. Chou, R. D. Majka, S. Wang, Z. Q. Yu, O. Kounina, Paolo Zuccon, Samuel C.C. Ting, H. Yi, H. Wu, Z. Cui, W. Tang, H. Shan, M. Qi, Matthias Heil, E. Finch, J. H. Zhang, S. Zhang, W. Creus, G. Laurenti, T. J. N. Nelson, E. Valente, M. Paniccia, A. Von Dratzig, Davide Rozza, K. Andeen, L. Farnesini, I. Rodríguez, Chuanguo Zhang, Z. L. Weng, D. Rapin, V. Plyaskin, A. Lebedev, A. Papi, Dong-Chul Son, P. Tang, J. W. Song, J. Wienkenhöver, Andrea Contin, Hengchang Liu, S. Lim, H. Sun, Philipp Azzarello, N. Masi, F. Luo, L. Barrin, Z. Qu, M. Willenbrock, J. J. Torsti, S. Pensotti, G. La Vacca, Mauro Tacconi, Roald Z. Sagdeev, Yang Yang, G. Schwering, Antonino Zichichi, G. Coignet, David Maurin, Xin Wu, J. Eppling, S. Della Torre, M. Crispoltoni, S. Rosier-Lees, J. Casaus, L. Qu, Chung-Cherng Lin, Teimuraz Lomtadze, M. B. Demirköz, C. Han, Henning Gast, M. Aguilar, Matteo Boschini, Chau-Hwang Lee, J. Berdugo, A. Fiasson, F. Dimiccoli, Wei Li, Laurent Derome, A. Bartoloni, X. Xia, C. Pizzolotto, R. J. García-López, Y. Fan, E. Choumilov, J. C. Marin, V. Poireau, Xubo Qin, P. Mott, Yun Shi, R. Kossakowski, Franck Cadoux, P. Nunes, A. Rozhkov, F. Spada, Lin Cheng, N. Picot-Clemente, F. Palmonari, M. Bourquin, C. Ting, L. Di Masso, M. Bizzarri, M. Duranti, E. Pedreschi, L. Basara, U. Becker, C. H. Chung, Xinxin Li, Y. J. Yu, S. Zeissler, Yu. Galaktionov, D. Aisa, I. Guerri, G. Boella, Varlen Grabski, M. Vecchi, Massimo Gervasi, Dong Liu, Z. Luo, Thomas Lippert, S. Q. Lu, Mayda Velasco, Valery Zhukov, M. T. Zhang, S. Vitillo, Z. M. Zheng, Fernando Barão, M. Pauluzzi, Bruce Rafael Mellado Garcia, Z. H. He, A. I. Chen, V. Vitale, F. Nozzoli, H. Jinchi, M. Behlmann, T. Siedenburg, A. Piluso, D. Cerreta, A. Ghelfi, M. Capell, Claudio Corti, Ningsheng Xu, G. Ambrosi, S. Caroff, J. Hoffman, T. Eronen, R. Clavero, D. Grandi, W. Xu, Naihua Wang, F. Cervelli, A. Obermeier, E. Gil, P. Lipari, T. Räihä, P. Goglov, I. Lazzizzera, M. Pohl, B. Bertucci, M. Xie, H. Ye, C. Mañá, Veronica Bindi, G. Scolieri, Nicola Tomassetti, Shihao Zhang, Hsiang Szu Chang, Behcet Alpat, Luísa Arruda, Antje Putze, T. Kirn, D. Haas, V. Vagelli, Shinhong Kim, C. Mo, Pier-Giorgio Rancoita, Q. Meng, Sadakazu Haino, H. L. Zhuang, A. Barrau, S. J. Schmidt, Q. L. Wang, C. Delgado, T. Urban, V. Choutko, A. Korkmaz, S. Seo, M. J. Chae, C. Guandalini, R. Pereira, M. Chen, K. Bollweg, Miaoran Lu, Zheng Wang, M. Habiby, B. Coste, M. Graziani, V. Formato, Horngming Hsieh, M. Incagli, K. Whitman, Ju Li, Roberto Battiston, B. Borgia, J. Yang, H. Guo, M. Müller, Changgi Huh, Zhijun Zhang, P. Saouter, S. Di Falco, Peter H. Fisher, Tim Martin, F. Giovacchini, Luca Morescalchi, Q. Xiong, K. Luebelsmeyer, Zhixiang Tang, M. Orcinha, A. Alvino, C. Vannini, S. Shan, P. von Doetinchem, N. Kim, X. D. Cai, F. Donnini, N. Attig, Hyun Lee, Andrei Kounine, Q. Yan, N. Zimmermann, S. Borsini, G. Castellini, J. Feng, G. Martinez, C. Palomares, C. Clark, S. Schael, C. Consolandi, Elisa Laudi, J. D. Burger, S. S. Vaurynovich, D. Tescaro, Yongyao Li, Mingming Yang, A. Oliva, D. D'Urso, C. Leluc, G. Gallucci, Yaomin Dai, B. Beischer, V. Bonnivard, K. Kanishev, S. Bizzaglia, Y. Jang, A. Bachlechner, X. B. Zhang, J. Bazo, V. Koutsenko, Eino Valtonen, Z. H. Li, Qiang Li, S. Ricol, M. Lolli, A. Eline, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Becker, Ulrich J., Behlmann, Matthew Daniel, Burger, Joseph D., Cai, Xudong, Capell, Michael H., Chen, Andrew I., Chen, H., Choumilov, Evgueni, Choutko, Vitali, Egorov, Alexander, Eline, Alexandre, Eppling, Frederic J., Fisher, Peter H., Galaktionov, Y., Goglov, Pavel, Heil, Melanie, Hsieh, Tsai-hsiu, Kounina, Olga, Kounine, Andrei, Koutsenko, Vladimir, Krafczyk, Matthew Scott, Lebedev, Alexei, Li, J. Q., Li, Q., Plyaskin, Vasily, Rozhkov, Andrey B., Shi, X. Y., Sun, Wei, Sun, W. H., Ting, Samuel, Ting, Susan Marks, Vaurynovich, Siarhei S., Wang, Xiaozhen, Weng, Zhili, Willenbrock, Manfred, Xie, M., Xu, Weiwei, Yan, Q., Zhang, S. D., Zuccon, Paolo, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Cortina Gil, Eduardo, Haas, Daniel, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Vitillo, Stefania, Wu, Xin, Aguilar, M, Aisa, D, Alpat, B, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Castellini, G, Cernuda, I, Cerreta, D, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, G, Chen, H, Cheng, L, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Gil, E, Coste, B, Creus, W, Crispoltoni, M, Cui, Z, Dai, Y, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Donnini, F, Duranti, M, D’Urso, D, Egorov, A, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Formato, V, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gargiulo, C, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Haas, D, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Korkmaz, M, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lolli, M, Lomtadze, T, Lu, M, Lu, S, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Morescalchi, L, Mott, P, Müller, M, Nelson, T, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pauluzzi, M, Pedreschi, E, Pensotti, S, Pereira, R, Picot Clemente, N, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Putze, A, Quadrani, L, Qi, X, Qin, X, Qu, Z, Räihä, T, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Schael, S, Schmidt, S, von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Song, J, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Vitale, V, Vitillo, S, Wang, L, Wang, N, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Willenbrock, M, Wu, H, Wu, X, Xia, X, Xie, M, Xie, S, Xiong, R, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Yang, Y, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, C, Zhang, J, Zhang, M, Zhang, S, Zhang, X, Zhang, Z, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Aguilar, M., Aisa, D., Alpat, B., Alvino, A., Ambrosi, G., Andeen, K., Arruda, L., Attig, N., Azzarello, P., Bachlechner, A., Barao, F., Barrau, A., Barrin, L., Bartoloni, A., Basara, L., Battarbee, M., Battiston, R., Bazo, J., Becker, U., Behlmann, M., Beischer, B., Berdugo, J., Bertucci, B., Bindi, V., Bizzaglia, S., Bizzarri, M., Boella, G., de Boer, W., Bollweg, K., Bonnivard, V., Borgia, B., Borsini, S., Boschini, M. j., Bourquin, M., Burger, J., Cadoux, F., Cai, X. d., Capell, M., Caroff, S., Casaus, J., Castellini, G., Cernuda, I., Cerreta, D., Cervelli, F., Chae, M. j., Chang, Y. h., Chen, A. i., Chen, G. m., Chen, H. s., Cheng, L., Chou, H. y., Choumilov, E., Choutko, V., Chung, C. h., Clark, C., Clavero, R., Coignet, G., Consolandi, C., Contin, A., Corti, C., Gil, E. Cortina, Coste, B., Creus, W., Crispoltoni, M., Cui, Z., Dai, Y. m., Delgado, C., Della Torre, S., Demirköz, M. b., Derome, L., Di Falco, S., Di Masso, L., Dimiccoli, F., Díaz, C., von Doetinchem, P., Donnini, F., Duranti, M., D’Urso, D., Egorov, A., Eline, A., Eppling, F. j., Eronen, T., Fan, Y. y., Farnesini, L., Feng, J., Fiandrini, E., Fiasson, A., Finch, E., Fisher, P., Formato, V., Gallucci, G., García, B., García-López, R., Gargiulo, C., Gast, H., Gebauer, I., Gervasi, M., Ghelfi, A., Giovacchini, F., Goglov, P., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Guandalini, C., Guerri, I., Guo, K. h., Haas, D., Habiby, M., Haino, S., Han, K. c., He, Z. h., Heil, M., Hoffman, J., Hsieh, T. h., Huang, Z. c., Huh, C., Incagli, M., Ionica, M., Jang, W. y., Jinchi, H., Kanishev, K., Kim, G. n., Kim, K. s., Kirn, Th., Korkmaz, M. a., Kossakowski, R., Kounina, O., Kounine, A., Koutsenko, V., Krafczyk, M. s., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H. t., Lee, S. c., Leluc, C., Li, H. l., Li, J. q., Li, T. x., Li, W., Li, Y., Li, Z. h., Li, Z. y., Lim, S., Lin, C. h., Lipari, P., Lippert, T., Liu, D., Liu, H., Liu, Hu, Lolli, M., Lomtadze, T., Lu, M. j., Lu, S. q., Lu, Y. s., Luebelsmeyer, K., Luo, F., Luo, J. z., Lv, S. s., Majka, R., Mañá, C., Marín, J., Martin, T., Martínez, G., Masi, N., Maurin, D., Menchaca-Rocha, A., Meng, Q., Mo, D. c., Morescalchi, L., Mott, P., Müller, M., Nelson, T., Ni, J. q., Nikonov, N., Nozzoli, F., Nunes, P., Obermeier, A., Oliva, A., Orcinha, M., Palmonari, F., Palomares, C., Paniccia, M., Papi, A., Pauluzzi, M., Pedreschi, E., Pensotti, S., Pereira, R., Picot-Clemente, N., Pilo, F., Piluso, A., Pizzolotto, C., Plyaskin, V., Pohl, M., Poireau, V., Putze, A., Quadrani, L., Qi, X. m., Qin, X., Qu, Z. y., Räihä, T., Rancoita, P. g., Rapin, D., Ricol, J. s., Rodríguez, I., Rosier-Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Sandweiss, J., Saouter, P., Schael, S., Schmidt, S. m., von Dratzig, A. Schulz, Schwering, G., Scolieri, G., Seo, E. s., Shan, B. s., Shan, Y. h., Shi, J. y., Shi, X. y., Shi, Y. m., Siedenburg, T., Son, D., Song, J. w., Spada, F., Spinella, F., Sun, W., Sun, W. h., Tacconi, M., Tang, C. p., Tang, X. w., Tang, Z. c., Tao, L., Tescaro, D., Ting, Samuel C. C., Ting, S. m., Tomassetti, N., Torsti, J., Türkoğlu, C., Urban, T., Vagelli, V., Valente, E., Vannini, C., Valtonen, E., Vaurynovich, S., Vecchi, M., Velasco, M., Vialle, J. p., Vitale, V., Vitillo, S., Wang, L. q., Wang, N. h., Wang, Q. l., Wang, R. s., Wang, X., Wang, Z. x., Weng, Z. l., Whitman, K., Wienkenhöver, J., Willenbrock, M., Wu, H., Wu, X., Xia, X., Xie, S., Xiong, R. q., Xu, N. s., Xu, W., Yang, J., Yang, M., Yang, Y., Ye, Q. h., Yi, H., Yu, Y. j., Yu, Z. q., Zeissler, S., Zhang, C., Zhang, J. h., Zhang, M. t., Zhang, S. d., Zhang, S. w., Zhang, X. b., Zhang, Z., Zheng, Z. m., Zhuang, H. l., Zhukov, V., Zichichi, A., Zimmermann, N., Zuccon, P., UCL - SST/IRMP - Institut de recherche en mathématique et physique, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and AMS Collaboration

Subjects
Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, chemistry.chemical_element, Cosmic ray, Astrophysics, ddc:500.2, Power law, Helium, Space missions, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], FIS/05 - ASTRONOMIA E ASTROFISICA, Physics and Astronomy (all), Rigidity (electromagnetism), International Space Station, Alpha Magnetic Spectrometer, ddc:550, AMS, Helium Flux, Primary Cosmic Rays, Cosmic rays, Physics, Spectral index, ta114, Cosmic Rays, Cosmic Helium, Spectral density, ASTROFÍSICA, Computational physics, FIS/01 - FISICA SPERIMENTALE, chemistry, Cosmic ray measurement, Cosmology, Rigidity, Space stations, Spectrometers
Abstract

Physical review letters 115(21), 211101 (2015). doi:10.1103/PhysRevLett.115.211101, Published by APS, College Park, Md.

Published
2015
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59. miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells

Author

S. Lv, Peter Kronenberger, Erik Teugels, Jan Sadones, Karel Fostier, Gang Chen, Caroline Geers, Ijeoma Adaku Umelo, Jacques De Greve, Alex Dewaele, Laboratory for Medical and Molecular Oncology, Internal Medicine Specializations, Laboratory of Molecullar and Cellular Therapy, Immunology and Microbiology, Supporting clinical sciences, and Pathology

Subjects
Male, Lung Neoplasms, cervical cancer, Afatinib, Cancer Treatment, Cetuximab, Apoptosis, Pharmacology, Lung and Intrathoracic Tumors, Cell Movement, Carcinoma, Non-Small-Cell Lung, Molecular Cell Biology, Basic Cancer Research, Pathology, Lung, Aged, 80 and over, Multidisciplinary, Cell Death, Cancer Risk Factors, NF-kappa B, Gene Therapy, Middle Aged, Signaling in Selected Disciplines, ErbB Receptors, Gene Expression Regulation, Neoplastic, Cell Motility, Oncology, Monoclonal, Medicine, Female, Erlotinib, medicine.drug, Signal Transduction, Research Article, Adult, Science, Biophysics, Antineoplastic Agents, Biology, Antibodies, Monoclonal, Humanized, Cell Growth, Predisposing Conditions and Syndromes, Gefitinib, Diagnostic Medicine, Cell Line, Tumor, microRNA, medicine, Humans, Lung cancer, neoplasms, Aged, Cell Proliferation, Oncogenic Signaling, Cell growth, Cancers and Neoplasms, medicine.disease, Non-Small Cell Lung Cancer, respiratory tract diseases, MicroRNAs, Cancer research, Biomarkers, General Pathology
Abstract

Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers. However, its role in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of this study was to investigate the contribution of miR-146a to various aspects of the malignant phenotype of human NSCLCs. In functional experiments, miR-146a suppressed cell growth, induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines (H358, H1650, H1975, HCC827 and H292). miR-146a also inhibited the migratory capacity of these NSCLC cells. On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab). These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were less potent compared to the effects of siRNA targeting of EGFR. Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling. We also found, in clinical formalin fixed paraffin embedded (FFPE) lung cancer samples, that low expression of miR-146a was correlated with advanced clinical TNM stages and distant metastasis in NSCLC (P

Published
2013

60. Mechanical Testing and Application of Steel-plastic Geogrid Instead of Metal Mesh in Supporting Engineering

Author

J.-X. Zhang, R.-S. Lv, T.-T. Wang, L.-Y. Tang, Z.-J. Hu, F. Xie, Y.-C. Kong, Q.-B. Wang, L. Xu, and Y. Bai

Subjects
Materials science, Mechanical Engineering, 0211 other engineering and technologies, 02 engineering and technology, Field tests, Geogrid, 020303 mechanical engineering & transports, 0203 mechanical engineering, Mechanics of Materials, Deflection (engineering), Ultimate tensile strength, Slab, Metal mesh, General Materials Science, Geotechnical engineering, 021101 geological & geomatics engineering
Abstract

The theory of the steel-plastic geogrid employed in supporting engineering is behind the practice, seriously affecting its popularization and application in engineering. Thus the tensile strength and deflection of steel-plastic geogrid and its control of surrounding rock deformations were studied and analyzed using laboratory and engineering field tests. We have contrasted the tensile strength of steel-plastic geogrid to that of metal mesh. We have also contrasted the deflection deformation of the steel-plastic geogrid concrete slabs to that of the mesh concrete slabs. In the tensile strength test, we have tested the tensile properties of three different types of steel-plastic geogrid. In the defection deformation test, two kinds of steel-plastic geogrid concrete slabs and the mesh concrete slabs are made to investigate the load and displacement they bear. By combining with the experimental application of the Wohu Mountain iron mine, we summarized the process of steel-plastic geogrid construction and monitored the surrounding rock deformation of test section. Thus, we drew the following conclusions: (1) the tensile strength of the steel-plastic geogrid was greater than metal mesh; (2) compared with metal mesh concrete slabs, steel plastic grille with concrete slab had a larger deflection and its stress tolerance ability was better; (3) the use of the steel-plastic geogrid supporting in roadway can control the deformation of its bottom and sidewalls.

Published
2016
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62. Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies

Author

Z. S. Lv, M. Y. Sun, S. L. Shi, and F. Wang

Subjects
Villous adenoma, Oncology, Male, medicine.medical_specialty, Colonic Polyps, Adenocarcinoma, Gastroenterology, Helicobacter Infections, Adenomatous Polyps, Tubular adenoma, Risk Factors, Internal medicine, medicine, Odds Ratio, Humans, Helicobacter, Intestinal Mucosa, biology, Helicobacter pylori, business.industry, Case-control study, Odds ratio, biology.organism_classification, medicine.disease, digestive system diseases, Meta-analysis, Disease Progression, Female, business, Colorectal Neoplasms
Abstract

Aim The study aimed to determine whether Helicobacter pylori infection is associated with colorectal adenocarcinoma and to quantify the extent of the risk. Method A literature search was performed to identify studies published between 1995 and 2012 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for colorectal adenocarcinoma and adenomatous polyp. Results Twenty-seven case-controlled studies involving 3450 adenocarcinoma patients, 1304 adenomatous polyp patients and more than 4000 controls were included. Helicobacter pylori was associated with an increased risk of colorectal adenocarcinoma and adenomatous polyp [odds ratio (OR) 1.24, 95% CI 1.12–1.37, P = 0.66; OR 1.87, 95% CI 1.53–2.28, P = 0.81]. There was a significant association between the CagA-positive strain and adenocarcinoma risk (OR 1.22, 95% CI 1.08–1.37, P = 0.05). In addition, there was an increased risk of tubular adenoma and villous adenoma formation (OR 3.06, 95% CI 1.98–4.73, P = 0.14; OR 2.05, 95% CI 0.84–4.97, P = 0.86). Conclusion The meta-analysis suggests a promoting effect of Helicobacter pylori on the risk of adenocarcinoma. It also suggests that Helicobacter infection might have its influence at the start of the adenomatous polyp disease sequence.

Published
2012

63. Analysis of temperature distribution in switched reluctance linear launcher

Author

Herbert Ho-Ching Iu, Hao Chen, Qianlong Wang, and S. Lv

Subjects
Materials science, business.industry, Stator, Electrical engineering, Mechanics, Finite element method, Switched reluctance motor, Power (physics), law.invention, Quantitative Biology::Subcellular Processes, law, Current sensor, Current (fluid), business, Thermal analysis, Communication channel
Abstract

This paper presents a thermal model of switched reluctance linear launcher. The accuracy of the thermal model is verified by comparing experimental data with those resulting derived from finite-element method (FEM) simulation. The temperature distribution of switched reluctance linear launcher is derived based on the stator copper losses as the main heat power measured the stator winding current by the current sensor. The maximum temperature rise curves with the different ambient temperature and the different heat power of the winding A, and the heat dissipation power of the 4 air convection surfaces with the different ambient temperature and the different heat power of the winding A are studied. Furthermore, this study achieves optimization in thickness of the stator plate and adding fins to the stator plate for heat dissipation with the present model. It is shown that the stator plate is the maximum heat dissipation power surface so that it can be adopted as the main heat dissipation channel and the effect of heat dissipation is obvious by adding fins to the stator plate.

Published
2012
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64. Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab

Author

Johnny Duerinck, Stephanie Du Four, Jan Sadones, Jacques De Greve, Sylvia De Brakeleer, Erik Teugels, S. Lv, Bart Neyns, Alex Michotte, Internal Medicine Specializations, Laboratory of Molecular and Medical Oncology, Department of Embryology and Genetics, Pathology, Neuroprotection & Neuromodulation, Physiology, Faculty of Medicine and Pharmacy, Laboratory of Molecullar and Cellular Therapy, Neurology, Anatomy, Medical Oncology, and Immunology and Microbiology

Subjects
Adult, Male, Cancer Research, IDH1, Cetuximab, Antineoplastic Agents, Biology, Antibodies, Monoclonal, Humanized, Clinical Trial, Phase II, Journal Article, medicine, PTEN, Humans, EGFR Gene Amplification, Progression-free survival, Prospective Studies, Aged, Brain Neoplasms, Research Support, Non-U.S. Gov't, Gene Amplification, PTEN Phosphohydrolase, Cancer, Antibodies, Monoclonal, Middle Aged, medicine.disease, Molecular medicine, Isocitrate Dehydrogenase, ErbB Receptors, Gene Expression Regulation, Neoplastic, Treatment Outcome, Oncology, Monoclonal, Cancer research, biology.protein, Female, Receptor, Epidermal Growth Factor, Neoplasm Recurrence, Local, Glioblastoma, medicine.drug
Abstract

Mutation and gene amplification of the epithelial growth factor receptor (EGFR) is one of the most common genetic alterations in glioblastoma (GB). EGFR is, therefore, an attractive molecular target for the treatment of GB. EGFR-targeted therapies however have been largely ineffective in clinical trials. In this study, we investigated the correlation between the EGFR gene amplification status, expression of the EGFR variant III (EGFRvIII) and EGFR variant IV (EGFRvIV) mutations, expression of the phosphatase and tensin homologue gene on chromosome 10 (PTEN) and mutation of the isocitrate dehydrogenase 1 (IDH1) gene and the survival of patients suffering from recurrent glioblastoma who were treated with the EGFR-targeted monoclonal antibody cetuximab in a prospective phase II clinical trial. EGFR amplification was detected in 19 out of 35 GB (54%), EGFRvIII expression in 11 (31.4%) and EGFRvIV expression in 7 (20%). The EGFRvIII and EGFRvIV mutations were exclusively found in GB with EGFR amplification and were almost mutually exclusive with IDH1 mutation (EGFRvIII mutation was found in 1 out of 11 GB with an IDH1 mutation). Patients with an EGFR amplification lacking EGFRvIII expression had a significantly superior progression free survival (PFS) and a numerical better overall survival (OS) following treatment with cetuximab [median PFS 3.03 vs. 1.63 months (p=0.006); median OS 5.57 vs. 3.97 months (p=0.12)]. Within the subgroup of patients with EGFR amplification, patients with EGFRvIII positive glioblastoma had a worse survival [median PFS 1.63 vs. 3.03 months (p=0.01); median OS 3.27 vs. 5.57 months (p=0.08)]. Our observations indicate that the type of EGFR mutation may determine the outcome of GB patients treated with cetuximab. Prospective investigation of both the EGFR amplification and mutation status in clinical trials with EGFR-targeted therapies for GB is indicated.

Published
2012

65. Nonsteroidal anti-inflammatory drugs and esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence: a meta-analysis

Author

F, Wang, Z S, Lv, and Y K, Fu

Subjects
Male, Time Factors, Aspirin, Esophageal Neoplasms, Incidence, Anti-Inflammatory Agents, Non-Steroidal, Adenocarcinoma, Risk Assessment, Cohort Studies, Barrett Esophagus, Case-Control Studies, Odds Ratio, Esophagitis, Humans, Female, Precancerous Conditions
Abstract

The incidence of esophageal adenocarcinoma has markedly increased in the last few decades and Barrett's esophagus is regarded as the precursor lesion of this cancer. The aim of the study was to quantify the adenocarcinoma risk associated with nonsteroidal anti-inflammatory drug use and to determine at which stage chemoprevention with this drug is the most effective in esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence. A literature search was performed to identify studies published between 1998 and 2009 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, and all nonsteroidal anti-inflammatory drugs. Four cohort and 10 case-control studies were included. Use of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs in normal population was associated with a reduced risk of adenocarcinoma (odds ratio [OR]: 0.73, 95% confidence interval [CI]: 0.65-0.83; OR: 0.84, 95% CI: 0.72-0.98, respectively). The use of all nonsteroidal anti-inflammatory drugs was associated with a reduced risk of adenocarcinoma (relative risk [RR]: 0.64, 95% CI: 0.42-0.96) in Barrett's esophagus patients. However, no obvious dose-effect relationships were found. In addition, we discovered a reverse association between drugs use and adenocarcinoma risk in people without a history of upper gastrointestinal tract disorders (OR: 0.57, 95% CI: 0.43-0.77, P= 0.12). Our meta-analyses suggest a protective effect of nonsteroidal anti-inflammatory drugs on the risk of adenocarcinoma. Our results also suggest that the drugs might act after the formation of Barrett's epithelium in the esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence.

Published
2010

67. ASP-based Collaborative Networked Manufacturing Service Platform for SMEs

Author

X. S. Chen, Y. Guo, Y. Su, W. H. Liao, H. B. Shi, and B. S. Lv

Subjects
Structure (mathematical logic), Service (systems architecture), Workflow, Resource (project management), Process management, Product lifecycle, Commerce, Computer science, Order (business), Process (engineering), Shared resource
Abstract

In order to enhance small to medium sized enterprises’ core competition, an ASP-based Collaborative Networked Manufacturing Service Platform (CNMSP) to promote resource sharing and advance collaboration level between enterprises is proposed. In this paper, the structure of CNMSP is introduced briefly. Collaborative workflow based on mixed modes of B/S and C/S, which aims at implementing collaborative process smoothly and serving product lifecycle successfully, is described in details. Resource as one important feature for supporting CNMSP is highlighted, and a resource estimation model and relevant award measures to urge distributed resource sharing are established. Finally, a Construction Machinery Networked Manufacturing Platform upon proposed structure is presented.

Published
2008
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68. Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial

Author

E Schmitt, C Smith, G Schulert, S Canna, A Grom, E Mellins, A Brown, J Smith, A Stevens, M Watson, S Jones, K Stewart, E Baker, A Kemp, T Davis, A Smith, S Jackson, C Williams, K Jones, T Mason, A Hanson, Y Zhao, B Thomas, A Reed, J Jones, J Cooper, T Lee, J Chang, M Holland, S Joshi, L Lim, C Ramírez, A Murphy, K Moore, E Pagano, B ferreira, S Li, P Lee, H Schmeling, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, J Olson, K Onel, L Ponder, S Prahalad, C Rabinovich, S Ringold, M Riordan, A Robinson, M Rosenkranz, B Rosolowski, N Ruth, K Schikler, H Stapp, R Syed, M Tesher, A Thatayatikom, R Vehe, E von Scheven, D Wahezi, A Watts, J Weiss, J Wagner, S Kim, Y Zhang, L Favier, J Patel, S Morgan, A Jackson, J Stokes, L Marques, Stephen J Balevic, K Hayward, A White, J Nicholas, D Lovell, A Zeft, J Harris, E Lawson, C Moss, N George, M Sutter, A Cooper, M Adams, S Cooper, M Miller, C Black, R Schneider, J Taylor, R Sran, M Oliver, M Twilt, M Tóth, J Walker, M Mitchell, F De Benedetti, N Singer, M Fox, K Kaufman, A Merritt, R Stevenson, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, J Woo, S Mohan, H Reid, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, A Hay, M Guzman, E Fox, P Hill, A PARSONS, S McGuire, J Lam, C Sandborg, B Stevens, J Boland, S Ballinger, E MENDOZA, J NOCTON, M Ritter, N Johnson, J Shirley, S Bowman, M Ibarra, S Hong, M Guevara, K James, L Santiago, A Adams, B DONALDSON, M Son, C Kremer, K Schmidt, T Wright, L Cannon, R Nicolai, M Freeman, S Spence, D Levy, J Paredes, K Gerhold, A Insalaco, T O'Brien, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, B O'Brien, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, B Obispo, O Okeke, K O'Neil, A Orandi, M Orlando, S Osei-Onomah, R Oz, A Paller, N Pan, S Panupattanapong, M Pardeo, K Pentakota, P Pepmueller, T Pfeiffer, K Phillippi, D Pires Marafon, R Pooni, S Pratt, S Protopapas, B Puplava, J Quach, M Quinlan-Waters, S Radhakrishna, J Rafko, J Raisian, A Rakestraw, E Ramsay, S Ramsey, R Randell, K Remmel, A Repp, A Reyes, A Richmond, M Riebschleger, M Riskalla, R Rivas-Chacon, E Rodela, M Rodriquez, K Rojas, T Ronis, H Rothermel, D Rothman, E Roth-Wojcicki, K Rouster-Stevens, T Rubinstein, N Saad, S Sabbagh, E Sacco, R Sadun, A Sanni, A Sarkissian, S Savani, L Scalzi, L Schanberg, S Scharnhorst, A Schlefman, K Schollaert-Fitch, T Seay, C Seper, J Shalen, R Sheets, A Shelly, S Shenoi, K Shergill, M Shishov, C Shivers, E Silverman, V Sivaraman, J Sletten, E Smitherman, J Soep, L Spiegel, J Spitznagle, H Srinivasalu, K Steigerwald, Y Sterba Rakovchik, S Stern, C Stingl, M Stoll, E Stringer, S Sule, J Sumner, R Sundel, G Syverson, A Szymanski, S Taber, R Tal, A Tambralli, A Taneja, T Tanner, S Tapani, G Tarshish, S Tarvin, L Tate, A Taxter, M Terry, K Tiffany, T Ting, A Tipp, D Toib, K Torok, C Toruner, H Tory, S Tse, V Tubwell, S Uriguen, T Valcarcel, H Van Mater, L Vannoy, C Varghese, N Vasquez, K Vazzana, K Veiga, J Velez, J Verbsky, G Vilar, N Volpe, S Vora, L Wagner-Weiner, H Waite, H Walters, T Wampler Muskardin, L Waqar, M Waterfield, P Weiser, P Weiss, E Wershba, A Wise, L Woolnough, E Wu, A Yalcindag, M Yee, E Yen, R Yeung, K Yomogida, Q Yu, R Zapata, A Zartoshti, R Zeft, A Zhu, C Zic, Daniel Weiner, Daniel Gonzalez, Rachel Randell, and Claire Beard

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Objective Determine the pharmacokinetics (PK) and exposure–response of hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE (pSLE).Methods We conducted an exploratory phase 2, direct-to-family trial. Children enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with a diagnosis of pSLE were eligible if they were receiving HCQ as standard of care for ≥3 months. Biological samples were collected at up to four visits over a 6-month period. At each visit, plasma was obtained to measure the concentrations of HCQ and DHCQ, as well as cytokines. HCQ and DHCQ plasma PK data were analysed using a population PK modelling approach.Results Twenty-five subjects provided a total of 88 plasma concentrations for PK analysis. There was a poor linear fit between HCQ concentrations and total body weight (R2=0.03). There was a decline in both interferon (IFN)-alpha and IFN-gamma with higher concentrations of HCQ and DHCQ. Volume of distribution for HCQ in plasma was higher in children compared with published values in adults (73 000 L vs 44 000 L), but clearance values in children were similar to adults.Conclusions We report the first population PK model for HCQ and DHCQ in children using data from a novel direct-to-family clinical trial. We observed high interindividual variability in HCQ PK and found that weight-based dosing for HCQ is poorly correlated with drug concentrations, suggesting the need to use therapeutic drug monitoring to individualise dosing. Furthermore, our results suggest that the current weight-based dosing paradigm for HCQ may result in suboptimal drug exposures, particularly for children with obesity. Accordingly, additional studies of HCQ are needed in pSLE to determine the optimal drug concentration and dosing to reduce disease activity and improve outcomes.Trial registration number NCT04358302.

Published
2022
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69. Distributed measurement and control system based on can bus

Author

Yang Chen, Xiaofang Gong, S. Lv, Rongsheng Gong, and Abu Zhang

Subjects
Engineering, Adaptive control, business.industry, Robustness (computer science), Control system, Real-time computing, Control reconfiguration, Networked control system, Robust control, business, Linear-quadratic-Gaussian control, CAN bus
Published
2005
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70. Mutation of Gluconobacter oxydans and Bacillus megaterium in a two-step process of l-ascorbic acid manufacture by ion beam

Author

S. Lv, B. Yan, A. Xu, J. Yao, Liang Yu, Z. Yu, and Jun Wang

Subjects
Gluconobacter oxydans, Ion beam, Nitrogen, Ascorbic Acid, Applied Microbiology and Biotechnology, Sugar acids, Ion, chemistry.chemical_compound, Industrial Microbiology, Heavy Ions, Bacillus megaterium, chemistry.chemical_classification, biology, Sugar Acids, Dose-Response Relationship, Radiation, General Medicine, Ascorbic acid, biology.organism_classification, Sorbose, Culture Media, Ion implantation, chemistry, Biochemistry, Mutagenesis, Protons, Biotechnology, Nuclear chemistry
Abstract

Aim: To increase the transformation rate of l-sorbose to 2-keto-l-gulonic (2-KLG) acid in a two-step process of l-ascrobic acid manufacture by ion beam. Methods and Results: Gluconobacter oxydans (GO29) and Bacillus megaterium (BM80) were used in the present study. Ion implantation was carried out with the heavy ion implantation facility at the institute of Plasma Physics in China. 2-KLG in whole culture broth was determined by iodometry. Mutants were screened by single-colony isolation and 2-KLG accumulation in broth. GO29 and BM80 were implanted by either hydrogen ions (H+) or nitrogen ions (N+) with various doses, respectively. The average transformation rate of GM112-302 bred by ion beam in Gram-molecule was increased from 79·3 to 94·5% after eight passages in shaking flasks. Furthermore, in 180-ton fermentors in Jiangsu Jiangshan Pharmaceutical Co. Ltd, the transformation rate was stable at 92·0%, indicating a producer could get 0·99 kg of gulonic acid from 1·0 kg of sorbose. Conclusion: Ion beam as a new mutation source had potential advantages in breeding. Comparing with original mixture GO29 and BM80, GM112-302 is more efficient in accumulating 2-KLG, especially at the later phase. Significance and Impact of the Study: GM112-302 bred by ion beam implantation dramatically increased the transformation rate by 19·2%, which greatly increased efficiency and reduced the cost of l-ascorbic acid manufacture in a two-step process.

Published
2004

72. MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma

Author

J Zhang, H Jin, H Liu, S lv, B Wang, R Wang, M Ding, Y Yang, L Li, S Fu, D Xie, M Wu, W Zhou, and Q Qian

Subjects
Cancer Research, PTEN, AGO2, Hepatocellular carcinoma, Biology, Cell cycle, medicine.disease_cause, Molecular oncology, digestive system diseases, Growth factor receptor, microRNA, Immunology, medicine, Cancer research, biology.protein, Tensin, Gene silencing, Original Article, Carcinogenesis, Molecular Biology, miR-99a
Abstract

The regulation network consisting of microRNAs (miRNAs) and their target genes remains largely elusive in hepatocellular carcinoma (HCC), especially the reciprocal loop between specific miRNAs and the miRNA processing machinery. In this study, we found that miR-99a was remarkably decreased in 111 of 152 (73.03%) primary HCC tissues and low-level expression of miR-99a was correlated with low tumor differentiation (P=0.001), liver cirrhosis (P=0.015), poor tumor-free survival (P=0.004) and overall survival (P=0.006) for HCC patients. By restoration of miR-99a, the HCC growth could be considerably inhibited both in vitro and in vivo. Subsequently, Argonaute-2 (Ago2), a central component of RNA-induced silencing complex, was found to be directly regulated by miR-99a via translational repression. Overexpression of Ago2 could partly impair the inhibitory effect of miR-99a on HCC cells in vitro. Then, we demonstrated that Ago2 was upregulated in HCC tissues at both RNA and protein levels and the expression of AGO2 protein and miR-99a was negatively correlated within detected HCC tissues (r=−0.727, P=0.004). Interestingly, the tumorigenicity of Ago2-knockdown HCC cells was severely impaired (4/10 vs 10/10, P

Published
2014

73. A multicenter, prospective, randomized, open comparator study on the treatment of ovulatory menorrhagia with tranexamic acid and norethisterone in mainland China

Author

F. He, Z. Cao, J. Lu, Y. Zhang, S. Lv, and S. Li

Subjects
Mainland China, medicine.medical_specialty, Norethisterone, business.industry, Obstetrics, media_common.quotation_subject, Obstetrics and Gynecology, Luteal phase, Regimen, Reproductive Medicine, Quality of life, Anesthesia, medicine, Adverse effect, business, Tranexamic acid, Menstrual cycle, medicine.drug, media_common
Published
2007
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74. Nonlinear dynamic characteristics of a flexible rotor system with local rub-impact

Author

X Y Tai, S Lv, B C Wen, H Ma, and H L Yi

Subjects
History, Engineering, Stator, business.industry, Rotor (electric), Continuous spectrum, Mechanics, Computer Science Applications, Education, law.invention, Piecewise linear function, Vibration, Physics::Popular Physics, Nonlinear system, law, Control theory, Waveform, Helicopter rotor, business
Abstract

In this paper, nonlinear dynamic characteristics of a single span rotor system with two discs are investigated under fixed-point and local arc rub-impact conditions. A twenty-degree-of-freedom model considering the gyroscopic effect is developed, the simple Coulomb friction model and piecewise linear spring model to describe the contact between the rotor and the stator. The vibration chracteristics of the rotor system with two types of rub-impact forms are analyzed with respect to the effects of rotating speed by using spectrum cascades, vibration waveforms, orbits and frequency spectra. The simulation results show that different rotor motions appear, such as P1(period-1), P2, P3 and P4 with the increasing rotating speed under two rub-impact conditions. And some combination frequency components and continuous spectra appear under the local arc rub-impact condition, which are different from those under the fixed-point rub-impact condition.

Published
2013
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75. Enhanced magnetoelectric effect in La0.67Sr0.33MnO3/PbZr0.52Ti0.48O3 multiferroic nanocomposite films with a SrRuO3 buffer layer

Author

M. H. Tang, X. S. Lv, J. He, Y. G. Xiao, H. Q. Cai, C. P. Cheng, Z. H. Tang, and Y. C. Zhou

Subjects
Magnetization, Scanning probe microscopy, Materials science, Nuclear magnetic resonance, Scanning electron microscope, Magnetoelectric effect, General Physics and Astronomy, Multiferroics, Composite material, Polarization (electrochemistry), Ferroelectricity, Pulsed laser deposition
Abstract

Epitaxial thin films of La0.67Sr0.33MnO3/PbZr0.52Ti0.48O3 (LSMO/PZT) were deposited on SrTiO3 substrates with a SrRuO3 buffer layer by employing the pulsed laser deposition method. Its crystal structure, surface morphology, and polarization switching were investigated by using X-ray diffraction, scanning electron microscopy, and piezo-force microscopy measurements, respectively. Ferroelectric behavior along with a remnant polarization (2Pr) of 62 μC/cm2, a saturated magnetization of ∼76 emu/cm3, and a magnetoelectric effect voltage coefficient αME around 202 mV/cm Oe and 300 mV/cm Oe at 1 kHz were obtained successfully for the LSMO/PZT bilayers at room temperature. The result indicated that the coupling effects of electric and magnetic fields exist in the fabricated composite thin films.

Published
2013
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76. Magnetoelectric coupling in La0.6Ca0.4MnO3-Bi0.6Nd0.4TiO3 composite thin films derived by a chemical solution deposition method

Author

X. S. Lv, Z. H. Tang, M. H. Tang, C. P. Cheng, and Y. G. Xiao

Subjects
Hysteresis, Materials science, Nuclear magnetic resonance, Physics and Astronomy (miscellaneous), Remanence, Electric field, Composite number, Coupling (piping), Composite material, Composite thin films, Magnetic hysteresis, Ferroelectricity
Abstract

Magnetoelectric (ME) xLa0.6Ca0.4MnO3-(1−x)Bi0.6Nd0.4TiO3 composite thin films with x = 0.3, 0.4, and 0.5 were fabricated on Pt/Ti/SiO2/Si(100) substrates by a chemical solution deposition method. The well-defined ferroelectric loops are observed. The Pr values are 11.2, 12.8, and 13.9 μC/cm2 under the condition of about 350 kV/cm electric field for the composite films with x = 0.3, 0.4, and 0.5. The composite films exhibit typical magnetic hysteresis loops, as well as remnant magnetizations. ME effect which is dependent on Hbias is observed. The results show that the films exhibit both good ferroelectric and magnetic properties, as well as a ME effect.

Published
2012
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77. Effect of doping concentration of substrate silicon on retention characteristics in metal-ferroelectric-insulator-semiconductor capacitors

Author

C. P. Cheng, B. Jiang, M. H. Tang, Y. C. Zhou, Y. Xiong, X. S. Lv, X. C. Gu, H. Q. Cai, J. C. Li, Y. G. Xiao, and Z. H. Tang

Subjects
Materials science, Physics and Astronomy (miscellaneous), Silicon, business.industry, Doping, chemistry.chemical_element, Insulator (electricity), Ferroelectricity, law.invention, Metal, Capacitor, Semiconductor, chemistry, law, visual_art, visual_art.visual_art_medium, Optoelectronics, Field based, business
Abstract

The polarization retention characteristics in metal-ferroelectric-insulator-semiconductor (MFIS) capacitor was theoretically investigated by considering depolarization field based on Lou’s polarization retention model [J. Appl. Phys. 105(9), 094107 (2009)]. The derived results demonstrated that the retention property can be effectively improved by enhancing the doping concentration of substrate silicon. Additionally, it is better to keep the MFIS capacitor at accumulation and depletion regions than at inversion region for improving the polarization retention property. It is expected that this investigation may offer some useful guidelines to the design and retention property improvement of MFIS capacitor and other MFIS structure devices.

Published
2012
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78. Temperature effect on electrical characteristics of negative capacitance ferroelectric field-effect transistors

Author

H. Q. Cai, J. C. Li, X. C. Gu, Z. H. Tang, Y. G. Xiao, X. S. Lv, B. Jiang, M. H. Tang, and C. P. Cheng

Subjects
Materials science, Physics and Astronomy (miscellaneous), business.industry, Transistor, Atmospheric temperature range, Ferroelectricity, Capacitance, Ferroelectric capacitor, law.invention, law, Ferroelectric thin films, Optoelectronics, Field-effect transistor, business, Negative impedance converter
Abstract

The electrical properties of negative capacitance (NC) ferroelectric field-effect transistors (FeFETs) were theoretically investigated in the temperature range from 280 to 360 K. The derived results indicate that for a fixed thickness of ferroelectric thin film the amplification of surface potential can be tuned by temperature. The transfer and output characteristics degrade with increasing temperature due to the gradual loss of ferroelectric NC effect. It is expected that the derived results may provide some insight into the design and performance improvement for the low power dissipation applications of FeFETs.

Published
2012
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80. Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial

Author

Laura E Schanberg, S Canna, A Grom, E Mellins, A Brown, S Jones, E Baker, A Kemp, T Davis, S Jackson, K Jones, T Mason, A Hanson, J Jones, J Cooper, T Lee, J Chang, M Holland, S Joshi, L Lim, A Murphy, K Moore, B ferreira, S Li, P Lee, K Abulaban, R Agbayani, S Akoghlanian, E Anderson, L Barillas-Arias, K Baszis, M Becker, H Bell-Brunson, H Benham, S Benseler, T Beukelman, H Brunner, H Bukulmez, L Cerracchio, E Chalom, K Chundru, J Dean, F Dedeoglu, V Dempsey, J Drew, B Feldman, P Ferguson, C Fleming, L Franco, I Goh, D Goldsmith, B Gottlieb, T Graham, T Griffin, M Hance, K Hickey, M Hollander, J Hsu, A Huber, C Hung, A Huttenlocher, L Imundo, C Inman, J Jaquith, L Jung, D Kingsbury, K Klein, M Klein-Gitelman, S Kramer, S Lapidus, D Latham, B Malla, M Malloy, A Martyniuk, K McConnell, D McCurdy, C McMullen-Jackson, L Moorthy, E Muscal, S Kim, L Favier, S Morgan, A Jackson, L Marques, Stephen J Balevic, K Hayward, J Nicholas, D Lovell, J Harris, E Lawson, C Moss, N George, A Cooper, Rachel L Randell, M Adams, S Cooper, M Miller, C Black, M Mitchell, F De Benedetti, M Fox, K Kaufman, A Merritt, J Fuller, M Fitzgerald, A Davis, C Davis, L Henderson, S Mohan, Y Kimura, L Harel, R Laxer, K McCarthy, I Ferguson, E McCormick, A Hay, M Guzman, E Fox, P Hill, S McGuire, J Lam, J Boland, S Ballinger, E MENDOZA, J NOCTON, N Johnson, S Bowman, M Ibarra, S Hong, M Guevara, K James, A Adams, B DONALDSON, C Kremer, L Cannon, R Nicolai, M Freeman, D Levy, K Gerhold, A Insalaco, W Bernal, E Kessler, C Lin, M Lerman, T Hahn, Lindsay Singler, Anthony Cunningham, Michael Cohen-Wolkowiez, Christoph P Hornik, N Abel, J Aiello, C Alejandro, E Allenspach, R Alperin, M Alpizar, G Amarilyo, W Ambler, S Ardoin, S Armendariz, I Balboni, S Balevic, L Ballenger, N Balmuri, F Barbar-Smiley, M Basiaga, E Beltz, T Bigley, B Binstadt, M Blakley, J Bohnsack, A Boneparth, C Bracaglia, E Brooks, M Brothers, M Buckley, D Bullock, B Cameron, P Carper, V Cartwright, E Cassidy, A Chang-Hoftman, V Chauhan, P Chira, T Chinn, H Clairman, D Co, A Confair, H Conlon, R Connor, C Correll, R Corvalan, D Costanzo, R Cron, L Curiel-Duran, T Curington, M Curry, A Dalrymple, D De Ranieri, M De Guzman, N Delnay, E DeSantis, T Dickson, J Dingle, E Dorsey, S Dover, J Dowling, K Driest, Q Du, K Duarte, D Durkee, E Duverger, J Dvergsten, A Eberhard, M Eckert, K Ede, B Edelheit, C Edens, Y Edgerly, M Elder, B Ervin, S Fadrhonc, C Failing, D Fair, M Falcon, S Federici, J Fennell, R Ferrucho, K Fields, T Finkel, O Flynn, L Fogel, K Fritz, S Froese, R Fuhlbrigge, D Gerstbacher, M Gilbert, M Gillispie-Taylor, E Giverc, C Godiwala, H Goheer, E Gotschlich, A Gotte, C Gracia, S Grevich, J Griswold, P Guittar, M Hager, O Halyabar, E Hammelev, S Haro, O Harry, E Hartigan, J Hausmann, J Heiart, K Hekl, M Henrickson, A Hersh, S Hillyer, L Hiraki, M Hiskey, P Hobday, C Hoffart, M Horwitz, J Huggins, J HuiYuen, J Huntington, G Janow, S Jared, C Justice, A Justiniano, N Karan, U Khalsa, B Kienzle, M Kitcharoensakkul, T Klausmeier, B Kompelien, A Kosikowski, L Kovalick, J Kracker, J Lai, B Lang, B Lapin, A Lasky, L Lentini, S Lieberman, N Ling, M Lingis, M Lo, D Lowman, N Luca, S Lvovich, C Madison, J Madison, S Magni Manzoni, J Maller, M Mannion, C Manos, S Mathus, L McAllister, P McCurdy Stokes, I McHale, A McMonagle, E Meidan, R Mercado, L Michalowski, P Miettunen, D Milojevic, E Mirizio, E Misajon, R Modica, E Morgan Dewitt, T Moussa, V Mruk, R Nadler, B Nahal, K Nanda, N Nasah, L Nassi, S Nativ, M Natter, J Neely, B Nelson, L Newhall, L Ng, P Nigrovic, B Nolan, E Oberle, and B Obispo

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Introduction Direct-to-family clinical trials efficiently provide data while reducing the participation burden for children and their families. Although these trials can offer significant advantages over traditional clinical trials, the process of designing and implementing direct-to-family studies is poorly defined, especially in children with rheumatic disease. This paper provides lessons learnt from the design and implementation of a self-controlled, direct-to-family pilot trial aimed to evaluate the effects of a medication management device on adherence to hydroxychloroquine in paediatric SLE.Methods Several design features accommodate a direct-to-family approach. Participants meeting eligibility criteria from across the USA were identified a priori through a disease registry, and all outcome data are collected remotely. The primary outcome (medication adherence) is evaluated using electronic medication event-monitoring, plasma drug levels, patient questionnaires and pill counts. Secondary and exploratory endpoints include (1) lupus disease activity measured by a remote SLE Disease Activity Index examination and the Systemic Lupus Activity Questionnaire; and (2) hydroxychloroquine pharmacokinetics and pharmacodynamics. Recruitment of the initial target of 20 participants was achieved within 10 days. Due to initial recruitment success, enrolment was increased to 26 participants. Additional participants who were interested were placed on a waiting list in case of dropouts during the study.Discussion and dissemination Direct-to-family trials offer several advantages but present unique challenges. Lessons learnt from the protocol development, design, and implementation of this trial will inform future direct-to-family trials for children and adults with rheumatic diseases. Additionally, the data collected remotely in this trial will provide critical information regarding the accuracy of teleresearch in lupus, the impact of adherence to hydroxychloroquine on disease activity and a pharmacokinetic analysis to inform paediatric-specific dosing of hydroxychloroquine.Trial registration number ClinicalTrials.gov Registry (NCT04358302).

Published
2021
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81. Experimental Study on the Atlanto-axial Joint and Related Structures with Regional Anatomy and Medical Imaging.

Author

S. Lv., He, H., Yang, L., Lin, Q., and Duan, S.

Abstract

Copyright of West Indian Medical Journal is the property of West Indian Medical Journal (WIMJ) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

83. An observational study of the first experience with bevacizumab for the treatment of patients with recurrent high-grade glioma in two belgian university hospitals

Author

Mike Huylebrouck, Johnny Duerinck, Sylvie Luce, O. De Witte, A. Van Binst, Alex Michotte, Isabelle Salmon, S. Lv, J. D'Haens, J. De Greve, Bart Neyns, Internal Medicine Specializations, Laboratory of Molecular and Medical Oncology, Surgical clinical sciences, Faculty of Medicine and Pharmacy, Neuroprotection & Neuromodulation, Neurosurgery, Radiology, Anatomy, and Surgery Specializations

Subjects
Oncology, medicine.medical_specialty, Pathology, Article Subject, Bevacizumab, Population, BEVACIZUMAB, Phases of clinical research, lcsh:RC254-282, Glioma, Internal medicine, glioma, Medicine, education, education.field_of_study, Intention-to-treat analysis, business.industry, Sciences bio-médicales et agricoles, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Clinical trial, Tolerability, Clinical Study, Observational study, business, medicine.drug
Abstract

Background. Bevacizumab (BEV), a humanized immunoglobulin G1 monoclonal antibody that inhibits VEGF has demonstrated activity against recurrent high-grade gliomas (HGG) in phase II clinical trials. Patients and Methods. Data were collected from patients with recurrent HGG who initiated treatment with BEV outside a clinical trial protocol at two Belgian university hospitals. Results. 19 patients (11 M/8 F) were administered a total of 138 cycles of BEV (median 4, range 1-31). Tumor response assessment by MRI was available for 15 patients; 2 complete responses and 3 partial responses for an objective response rate of 26 for the intent to treat population were observed on gadolinium-enhanced T1-weighted images; significant regressions on T2/FLAIR were documented in 10 out of 15 patients (67). A reduced uptake on PET was documented in 3 out of 4 evaluable patients. The six-month progression-free survival was 21% (95 CI 2.7-39.5). Two patients had an ongoing tumor response and remained free from progression after 12 months of BEV treatment. Conclusions. The activity and tolerability of BEV were comparable to results from previous prospective phase II trials. Reduced uptake on PET suggests a metabolic response in addition to an antiangiogenic effect in some cases with favorable clinical outcome. Copyright 2012 M. Huylebrouck et al., SCOPUS: ar.j, info:eu-repo/semantics/published

84. Phase II study of sunitinib malate in patients with recurrent high-grade glioma

Author

Olli Tynninen, Johnny Duerinck, J. De Greve, Nina N. Nupponen, S. Lv, Alex Michotte, Cristo Chaskis, Martine Dujardin, Hendrik Everaert, Bart Neyns, Jan Sadones, Internal Medicine Specializations, Supporting clinical sciences, Pathology, Medical Imaging and Physical Sciences, Medical Imaging, Laboratory for Medical and Molecular Oncology, Surgical clinical sciences, Faculty of Medicine and Pharmacy, Neuroprotection & Neuromodulation, Neurosurgery, and Anatomy

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Indoles, PDGFR, medicine.medical_treatment, Phases of clinical research, Antineoplastic Agents, Neutropenia, Gastroenterology, Central Nervous System Neoplasms, VEGFR, Recurrence, Internal medicine, Sunitinib, medicine, Humans, Pyrroles, Receptors, Platelet-Derived Growth Factor, Aged, Chemotherapy, business.industry, glioblastoma, KIT, Glioma, Middle Aged, Sunitinib malate, medicine.disease, Magnetic Resonance Imaging, Vascular Endothelial Growth Factor Receptor-2, Pyrrolidinones, Proto-Oncogene Proteins c-kit, Neurology, Oncology, Cerebral blood flow, Regional Blood Flow, Cerebrovascular Circulation, Positron-Emission Tomography, Toxicity, Disease Progression, Female, Neurology (clinical), Lymphocytopenia, business, Neo-angiogenesis, medicine.drug
Abstract

Receptor tyrosine kinase signaling causes profound neo-angiogenesis in high-grade gliomas (HGG). The KIT, PDGFR-?, and VEGFR2 genes are frequently amplified and expressed in HGG and are molecular targets for therapeutic inhibition by the small-molecule kinase inhibitor sunitinib malate. Twenty-one patients with progressive HGG after prior radiotherapy and chemotherapy received a daily dose of 37.5 mg sunitinib until progression or unacceptable toxicity. Magnetic resonance imaging (MRI) and dynamic susceptibility contrast (DSC)-enhanced perfusion measurements were performed before and during therapy. Cerebral blood volume (CBV) and cerebral blood flow (CBF) lesion-to-normal-white matter ratios were measured to evaluate the antiangiogenic effects of sunitinib. The most frequent grade ?3 adverse events were skin toxicity, neutropenia, thrombocytopenia, and lymphocytopenia. None of the patients achieved an objective response, whereas a decrease in CBV and CBF within the lesion compared with the normal brain was documented in four out of 14 (29%) patients evaluable for DSC-enhanced perfusion measurements. All patients experienced progression of their disease before or after eight weeks of therapy. Median time-to-progression and overall survival were 1.6 (95%CI 0.8-2.5) and 3.8 (95% CI 2.2-5.3) months, respectively. No correlation could be established between VEGFR2, PDGFR-?, and KIT gene copy numbers or protein expression and the effects of sunitinib. Single-agent sunitinib at 37.5 mg/day had insufficient activity to warrant further investigation of this monotherapy regimen in recurrent HGG.

85. Different physicochemical behaviors of nitrate and ammonium during transport: a case study on Mt. Hua, China

Author

C. Wu, C. Cao, J. Li, S. Lv, X. Liu, S. Zhang, S. Liu, F. Zhang, J. Meng, and G. Wang

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

To understand the chemical evolution of aerosols in the transport process, the chemistry of PM2.5 and nitrogen isotope compositions on the mountainside of Mt. Hua (∼1120 m above sea level, a.s.l.) in inland China during the 2016 summertime were investigated and compared with parallel observations collected at surface sampling site (∼400 m a.s.l.). The PM2.5 exhibited a high level at the mountain foot site (MF; average 76.0±44.1 µg m−3) and could be transported aloft by anabatic valley winds, leading to the gradual accumulation of daytime PM2.5 with a noon peak at the mountainside sampling site (MS). As the predominant ion species, sulfate exhibited nearly identical mass concentrations at both sites, but its PM2.5 mass fraction was moderately enhanced by ∼4 % at the MS site. The ammonium variations were similar to the sulfate variations, the chemical forms of both of which mainly existed as ammonium bisulfate (NH4HSO4) and ammonium sulfate ((NH4)2SO4) at the MF and MS sites, respectively. Unlike sulfate and ammonium, nitrate mainly existed as ammonium nitrate (NH4NO3) in fine particles and exhibited decreasing mass concentration and proportion trends with increasing elevation. This finding was ascribed to NH4NO3 volatilization, in which gaseous HNO3 from semi-volatile NH4NO3 subsequently reacted with dust particles to form nonvolatile salts, resulting in significant nitrate shifts from fine particles into coarse particles. Such scavenging of fine-particle nitrate led to an enrichment in the daytime 15N of nitrate at the MS site compared with to the MF site. In contrast to nitrate, at the MS site, the 15N in ammonium depleted during the daytime. Considering the lack of any significant change in ammonia (NH3) sources during the vertical transport process, this 15N depletion in ammonium was mainly the result of unidirectional reactions, indicating that additional NH3 would partition into particulate phases and further neutralize HSO4- to form SO42-. This process would reduce the aerosol acidity, with a higher pH (3.4±2.2) at the MS site and lower ones (2.9±2.0) at the MF site. Our work provides more insight into physicochemical behaviors of semi-volatile nitrate and ammonium, which will facilitate the improvement in the model for a better simulation of aerosol composition and properties.

Published
2022
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86. Required sampling density of ground-based soil moisture and brightness temperature observations for calibration and validation of L-band satellite observations based on a virtual reality

Author

S. Lv, B. Schalge, P. Saavedra Garfias, and C. Simmer

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

Microwave remote sensing is the most promising tool for monitoring near-surface soil moisture distributions globally. With the Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) missions in orbit, considerable efforts are being made to evaluate derived soil moisture products via ground observations, microwave transfer simulation, and independent remote sensing retrievals. Due to the large footprint of the satellite radiometers of about 40 km in diameter and the spatial heterogeneity of soil moisture, minimum sampling densities for soil moisture are required to challenge the targeted precision. Here we use 400 m resolution simulations with the regional Terrestrial System Modeling Platform (TerrSysMP) and its coupling with the Community Microwave Emission Modelling platform (CMEM) to quantify the maximum sampling distance allowed for soil moisture and brightness temperature validation. Our analysis suggests that an overall sampling distance of finer than 6 km is required to validate the targeted accuracy of 0.04 cm3 cm−3 with a 70 % confidence level in SMOS and SMAP estimates over typical mid-latitude European regions. The maximum allowed sampling distance depends on the land-surface heterogeneity and the meteorological situation, which influences the soil moisture patterns, and ranges from about 6 to 17 km for a 70 % confidence level for a typical year. At the maximum allowed sampling distance on a 70 % confidence level, the accuracy of footprint-averaged soil moisture is equal to or better than brightness temperature estimates over the same area. Estimates strongly deteriorate with larger sampling distances. For the evaluation of the smaller footprints of the active and active–passive products of SMAP the required sampling densities increase; e.g., when a grid resolution of 3 km diameter is sampled by three sites of footprints of 9 km sampled by five sites required, only 50 %–60 % of the pixels have a sampling error below the nominal values. The required minimum sampling densities for ground-based radiometer networks to estimate footprint-averaged brightness temperature are higher than for soil moisture due to the non-linearities of radiative transfer, and only weakly correlated in space and time. This study provides a basis for a better understanding of the sometimes strong mismatches between derived satellite soil moisture products and ground-based measurements.

Published
2020
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87. Analysis of soil hydraulic and thermal properties for land surface modeling over the Tibetan Plateau

Author

H. Zhao, Y. Zeng, S. Lv, and Z. Su

Subjects
Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

Soil information (e.g., soil texture and porosity) from existing soil datasets over the Tibetan Plateau (TP) is claimed to be inadequate and even inaccurate for determining soil hydraulic properties (SHP) and soil thermal properties (STP), hampering the understanding of the land surface process over TP. As the soil varies across three dominant climate zones (i.e., arid, semi-arid and subhumid) over the TP, the associated SHP and STP are expected to vary correspondingly. To obtain an explicit insight into the soil hydrothermal properties over the TP, in situ and laboratory measurements of over 30 soil property profiles were obtained across the climate zones. Results show that porosity and SHP and STP differ across the climate zones and strongly depend on soil texture. In particular, it is proposed that gravel impact on porosity and SHP and STP are both considered in the arid zone and in deep layers of the semi-arid zone. Parameterization schemes for porosity, SHP and STP are investigated and compared with measurements taken. To determine the SHP, including soil water retention curves (SWRCs) and hydraulic conductivities, the pedotransfer functions (PTFs) developed by Cosby et al. (1984) (for the Clapp–Hornberger model) and the continuous PTFs given by Wösten et al. (1999) (for the Van Genuchten–Mualem model) are recommended. The STP parameterization scheme proposed by Farouki (1981) based on the model of De Vries (1963) performed better across the TP than other schemes. Using the parameterization schemes mentioned above, the uncertainties of five existing regional and global soil datasets and their derived SHP and STP over the TP are quantified through comparison with in situ and laboratory measurements. The measured soil physical properties dataset is available at https://data.4tu.nl/repository/uuid:c712717c-6ac0-47ff-9d58-97f88082ddc0.

Published
2018
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88. The role of acoustic phonon anharmonicity in determining thermal conductivity of CdSiP2 and AgGaS2: First principles calculations

Author

Lei Wei, X. P. Wang, B. Liu, Y. Y. Zhang, X. S. Lv, Y. G. Yang, H. J. Zhang, and Xian Zhao

Subjects
Physics, QC1-999
Abstract

Thermal conductivity of single-crystal materials is crucial in the fields of lasers and nonlinear optics. Understanding the physical mechanism of thermal conductivity in such systems is therefore of great importance. In the present work, first principles calculations were employed to study the thermal conductivity of the infrared nonlinear optical materials, CdSiP2 and AgGaS2. These compounds crystallize in similar structures but with an order-of-magnitude difference in thermal conductivity. The average Grüneisen parameters are −0.8 and −2.6 for CdSiP2 and AgGaS2, respectively; these values are indicative of the soft-mode phenomenon of acoustic phonons. Crystal structures are considered unstable at low temperature through the whole Brillouin zone, especially in the region from K-point X to Γ. Acoustic phonon anharmonicity is concluded to be the main factor that determines the magnitude of thermal conductivity.

Published
2015
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89. Precision Measurement of the Boron to Carbon Flux Ratio in Cosmic Rays from 1.9 GV to 2.6 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author

Aguilar, M, Ali Cavasonza, L, Alpat, B, Ambrosi, G, Arruda, L, Attig, N, Aupetit, S, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Başeǧmez-du Pree, S, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bindi, V, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Boschini, M J, Bourquin, M, Bueno, E F, Burger, J, Cadoux, F, Cai, X D, Capell, M, Caroff, S, Casaus, J, Castellini, G, Cernuda, I, Cervelli, F, Chae, M J, Chang, Y H, Chen, A I, Chen, G M, Chen, H S, Cheng, L, Chou, H Y, Choumilov, E, Choutko, V, Chung, C H, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Creus, W, Crispoltoni, M, Cui, Z, Dai, Y M, Delgado, C, Della Torre, S, Demirköz, M B, Derome, L, Di Falco, S, Dimiccoli, F, Díaz, C, von Doetinchem, P, Dong, F, Donnini, F, Duranti, M, D'Urso, D, Egorov, A, Eline, A, Eronen, T, Feng, J, Fiandrini, E, Finch, E, Fisher, P, Formato, V, Galaktionov, Y, Gallucci, G, García, B, García-López, R J, Gargiulo, C, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Giovacchini, F, Goglov, P, Gómez-Coral, D M, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guerri, I, Guo, K H, Habiby, M, Haino, S, Han, K C, He, Z H, Heil, M, Hoffman, J, Hsieh, T H, Huang, H, Huang, Z C, Huh, C, Incagli, M, Ionica, M, Jang, W Y, Jinchi, H, Kang, S C, Kanishev, K, Kim, G N, Kim, K S, Kirn, Th, Konak, C, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M S, La Vacca, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H T, Lee, S C, Leluc, C, Li, H S, Li, J Q, Li, Q, Li, T X, Li, W, Li, Z H, Li, Z Y, Lim, S, Lin, C H, Lipari, P, Lippert, T, Liu, D, Liu, Hu, Lu, S Q, Lu, Y S, Luebelsmeyer, K, Luo, F, Luo, J Z, Lv, S S, Majka, R, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca-Rocha, A, Meng, Q, Mo, D C, Morescalchi, L, Mott, P, Nelson, T, Ni, J Q, Nikonov, N, Nozzoli, F, Nunes, P, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Pauluzzi, M, Pensotti, S, Pereira, R, Picot-Clemente, N, Pilo, F, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Putze, A, Quadrani, L, Qi, X M, Qin, X, Qu, Z Y, Räihä, T, Rancoita, P G, Rapin, D, Ricol, J S, Rodríguez, I, Rosier-Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Schael, S, Schmidt, S M, Schulz von Dratzig, A, Schwering, G, Seo, E S, Shan, B S, Shi, J Y, Siedenburg, T, Son, D, Song, J W, Sun, W H, Tacconi, M, Tang, X W, Tang, Z C, Tao, L, Tescaro, D, Ting, Samuel C C, Ting, S M, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vázquez Acosta, M, Vecchi, M, Velasco, M, Vialle, J P, Vitale, V, Vitillo, S, Wang, L Q, Wang, N H, Wang, Q L, Wang, X, Wang, X Q, Wang, Z X, Wei, C C, Weng, Z L, Whitman, K, Wienkenhöver, J, Willenbrock, M, Wu, H, Wu, X, Xia, X, Xiong, R Q, Xu, W, Yan, Q, Yang, J, Yang, M, Yang, Y, Yi, H, Yu, Y J, Yu, Z Q, Zeissler, S, Zhang, C, Zhang, J, Zhang, J H, Zhang, S D, Zhang, S W, Zhang, Z, Zheng, Z M, Zhu, Z Q, Zhuang, H L, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Becker, Ulrich J, Behlmann, Matthew Daniel, Burger, Joseph D, Cai, Xudong, Capell, Michael H, Chen, A. I., Choumilov, Evgueni, Choutko, Vitali, Demakov, O., Egorov, Alexander, Eline, Alexandre, Fisher, P., Galaktionov, Y., Goglov, Pavel, Heil, Melanie, Hsieh, T. H., Kounina, Olga, Kounine, Andrei, Koutsenko, Vladimir, Krafczyk, Matthew Scott, Lebedev, Alexei, Li, J. Q., Plyaskin, Vasily, Rozhkov, Andrey B., Sun, W. H., Ting, Samuel, Ting, S. M., Wang, X., Weng, Z. L., Xu, W., Yan, Q., Zhang, J., Zhang, S. D., Zhang, Z., Zuccon, Paolo, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AMS Collaboration, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Vitillo, Stefania, Wu, Xin, Aguilar, M., Ali Cavasonza, L., Ambrosi, G., Arruda, L., Attig, N., Aupetit, S., Azzarello, P., Bachlechner, A., Barao, F., Barrau, A., Barrin, L., Bartoloni, A., Basara, L., Başeğmez du Pree, S., Battarbee, M., Battiston, R., Becker, U., Behlmann, M., Beischer, B., Berdugo, J., Bertucci, B., Bindel, K. . f., Bindi, V., Boella, G., de Boer, W., Bollweg, K., Bonnivard, V., Borgia, B., Boschini, M. . j., Bourquin, M., Bueno, E. . f., Burger, J., Cadoux, F., Cai, X. . d., Capell, M., Caroff, S., Casaus, J., Castellini, G., Cervelli, F., Chae, M. . j., Chang, Y. . h., Chen, A. . i., Chen, G. . m., Chen, H. . s., Cheng, L., Chou, H. . y., Choumilov, E., Choutko, V., Chung, C. . h., Clark, C., Clavero, R., Coignet, G., Consolandi, C., Contin, Andrea, Corti, C., Creus, W., Crispoltoni, M., Cui, Z., Dai, Y. . m., Delgado, C., Della Torre, S., Demirköz, M. . b., Derome, L., Di Falco, S., Dimiccoli, F., Díaz, C., von Doetinchem, P., Dong, F., Donnini, F., Duranti, M., D’Urso, D., Egorov, A., Eline, A., Eronen, T., Feng, J., Fiandrini, E., Finch, E., Formato, V., Gallucci, G., García, B., García López, R. . j., Gargiulo, C., Gast, H., Gebauer, I., Gervasi, M., Ghelfi, A., Giovacchini, F., Goglov, P., Gómez Coral, D. . m., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Guo, K. . h., Haino, S., Han, K. . c., Z. . h., He, Heil, M., Hoffman, J., Hsieh, T. . h., Huang, H., Huang, Z. . c., Huh, C., Incagli, M., Ionica, M., Jang, W. . y., Jinchi, H., Kang, S. . c., Kanishev, K., Kim, G. . n., Kim, K. . s., Kirn, T. h., Konak, C., Kounina, O., Kounine, A., Koutsenko, V., Krafczyk, M. . s., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H. . t., Lee, S. . c., Leluc, C., H. . s., Li, J. . q., Li, Li, Q., T. . x., Li, Li, W., Li, Y., Z. . h., Li, Z. . y., Li, Lim, S., Lin, C. . h., Lipari, P., Lippert, T., Liu, D., Liu, Hu, Lordello, V. . d., S. . q., Lu, Y. . s., Lu, Luebelsmeyer, K., Luo, F., Luo, J. . z., S. . s., Lv, Machate, F., Majka, R., Mañá, C., Marín, J., Martin, T., Martínez, G., Masi, Nicolo', Maurin, D., Menchaca Rocha, A., Meng, Q., Mikuni, V. . m., D. . c., Mo, Morescalchi, L., Mott, P., Nelson, T., J. . q., Ni, Nikonov, N., Nozzoli, F., Oliva, A., Orcinha, M., Palmonari, Federico, Palomares, C., Paniccia, M., Pauluzzi, M., Pensotti, S., Pereira, R., Picot Clemente, N., Pilo, F., Pizzolotto, C., Plyaskin, V., Pohl, M., Poireau, V., Putze, A., Quadrani, Lucio, X. . m., Qi, Qin, X., Z. . y., Qu, Räihä, T., Rancoita, P. . g., Rapin, D., Ricol, J. . s., Rosier Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Sandweiss, J., Saouter, P., Schael, S., Schmidt, S. . m., Schulz von Dratzig, A., Schwering, G., Seo, E. . s., Shan, B. . s., Shi, J. . y., Siedenburg, T., Son, D., Song, J. . w., Sun, W. . h., Tacconi, M., Tang, X. . w., Tang, Z. . c., Tao, L., Tescaro, D., Ting, Samuel C. . C., Ting, S. . m., Tomassetti, N., Torsti, J., Türkoğlu, C., Urban, T., Vagelli, V., Valente, E., Vannini, C., Valtonen, E., Vázquez Acosta, M., Vecchi, M., Velasco, M., Vialle, J. . p., Vitale, V., Vitillo, S., Wang, L. . q., Wang, N. . h., Wang, Q. . l., Wang, X. . q., Wang, Z. . x., Wei, C. . c., Weng, Z. . l., Whitman, K., Wienkenhöver, J., Wu, H., Wu, X., Xia, X., Xiong, R. . q., Yang, J., Yang, M., Yang, Y., Yi, H., Y. . j., Yu, Z. . q., Yu, Zeissler, S., Zhang, C., Zhang, J. . h., Zhang, S. . d., Zhang, S. . w., Zheng, Z. . m., Zhu, Z. . q., Zhuang, H. . l., Zhukov, V., Zichichi, Antonino, Zimmermann, N., Zuccon, P., Aguilar, M, Ali Cavasonza, L, Ambrosi, G, Arruda, L, Attig, N, Aupetit, S, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Başeğmez du Pree, S, Battarbee, M, Battiston, R, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bindel, K, Bindi, V, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Boschini, M, Bourquin, M, Bueno, E, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Castellini, G, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, G, Chen, H, Cheng, L, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Creus, W, Crispoltoni, M, Cui, Z, Dai, Y, Delgado, C, Della Torre, S, Demakov, O, Demirköz, M, Derome, L, Di Falco, S, Dimiccoli, F, Díaz, C, von Doetinchem, P, Dong, F, Donnini, F, Duranti, M, D’Urso, D, Egorov, A, Eline, A, Eronen, T, Feng, J, Fiandrini, E, Finch, E, Fisher, P, Formato, V, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gargiulo, C, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Giovacchini, F, Goglov, P, Gómez Coral, D, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guo, K, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, H, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kang, S, Kanishev, K, Kim, G, Kim, K, Kirn, T, Konak, C, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lordello, V, Lu, S, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Machate, F, Majka, R, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mikuni, V, Mo, D, Morescalchi, L, Mott, P, Nelson, T, Ni, J, Nikonov, N, Nozzoli, F, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Pauluzzi, M, Pensotti, S, Pereira, R, Picot Clemente, N, Pilo, F, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Putze, A, Quadrani, L, Qi, X, Qin, X, Qu, Z, Räihä, T, Rancoita, P, Rapin, D, Ricol, J, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Schael, S, Schmidt, S, Schulz von Dratzig, A, Schwering, G, Seo, E, Shan, B, Shi, J, Siedenburg, T, Son, D, Song, J, Sun, W, Tacconi, M, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vázquez Acosta, M, Vecchi, M, Velasco, M, Vialle, J, Vitale, V, Vitillo, S, Wang, L, Wang, N, Wang, Q, Wang, X, Wang, Z, Wei, C, Weng, Z, Whitman, K, Wienkenhöver, J, Wu, H, Wu, X, Xia, X, Xiong, R, Xu, W, Yan, Q, Yang, J, Yang, M, Yang, Y, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, C, Zhang, J, Zhang, S, Zhang, Z, Zheng, Z, Zhu, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, and Zuccon, P

Subjects
Astrophysics and Astronomy, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], General Physics and Astronomy, chemistry.chemical_element, Cosmic ray, Astrophysics, Cosmic Rays, Galactic propagation, ddc:500.2, 01 natural sciences, Power law, Space missions, FIS/05 - ASTRONOMIA E ASTROFISICA, Physics and Astronomy (all), Rigidity (electromagnetism), AMS-02, boron, carbon, flux ratio, 0103 physical sciences, Alpha Magnetic Spectrometer, ddc:550, ddc:530, AMS, Boron, 010303 astronomy & astrophysics, Cosmic rays, Physics, Cosmic-ray propagation, Spectral index, ta114, 010308 nuclear & particles physics, Turbulence, Spectral density, Boron to carbon ratio, Carbon, FIS/01 - FISICA SPERIMENTALE, chemistry, Cosmic ray measurement, Cosmology, Rigidity, Space stations, Spectrometers
Abstract

Knowledge of the rigidity dependence of the boron to carbon flux ratio (B/C) is important in understanding the propagation of cosmic rays. The precise measurement of the B/C ratio from 1.9 GV to 2.6 TV, based on 2.3 million boron and 8.3 million carbon nuclei collected by AMS during the first 5 years of operation, is presented. The detailed variation with rigidity of the B/C spectral index is reported for the first time. The B/C ratio does not show any significant structures in contrast to many cosmic ray models that require such structures at high rigidities. Remarkably, above 65 GV, the B/C ratio is well described by a single power law R[superscript Δ] with index Δ=-0.333±0.014(fit)±0.005(syst), in good agreement with the Kolmogorov theory of turbulence which predicts Δ=-1/3 asymptotically., National Science Foundation (U.S.) (Grants 1455202 and 1551980), Wyle Research (Firm) (Grant 2014/T72497), United States. National Aeronautics and Space Administration (NASA Earth and Space Science Fellowship Grant HELIO15F-0005)

Published
2016
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90. Electron and Positron Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station

Author

Aguilar, M, Aisa, D, Alvino, A, Ambrosi, Giovanni, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, Bruna, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, Mj, Bourquin, M, Burger, J, Cadoux, F, Cai, Xd, Capell, M, Caroff, S, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cervelli, F, Chae, Mj, Chang, Yh, Chen, Ai, Chen, H, Cheng, Gm, Chen, Hs, Cheng, L, Chikanian, A, Chou, Hy, Choumilov, E, Choutko, V, Chung, Ch, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, Mb, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Du, Wj, Duranti, Matteo, D'Urso, D, Eline, A, Eppling, Fj, Eronen, T, Fan, Yy, Farnesini, L, Feng, J, Fiandrini, Emanuele, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, Maura, Guandalini, C, Guerri, I, Guo, Kh, Habiby, M, Haino, S, Han, Kc, He, Zh, Heil, M, Hoffman, J, Hsieh, Th, Huang, Zc, Huh, C, Incagli, M, Ionica, Maria, Jang, Wy, Jinchi, H, Kanishev, K, Kim, Gn, Kim, Ks, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, Ms, Kunz, S, La Vacca, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, Ht, Lee, Sc, Leluc, C, Li, Hl, Li, Jq, Li, Q, Li, Tx, Li, W, Li, Y, Li, Zh, Li, Zy, Lim, S, Lin, Ch, Lipari, P, Lippert, T, Liu, D, Liu, H, Lomtadze, T, Lu, Mj, Lu, Ys, Luebelsmeyer, K, Luo, F, Luo, Jz, Lv, Ss, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, Dc, Morescalchi, L, Mott, P, Müller, M, Ni, Jq, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pedreschi, E, Pensotti, S, Pereira, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, Xm, Rancoita, Pg, Rapin, D, Ricol, Js, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, Sm, Schuckardt, D, von Dratzig AS, Schwering, G, Scolieri, G, Seo, Es, Shan, Bs, Shan, Yh, Shi, Jy, Shi, Xy, Shi, Ym, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Sun, Wh, Tacconi, M, Tang, Cp, Tang, Xw, Tang, Zc, Tao, L, Tescaro, D, Ting, Sc, Ting, Sm, Tomassetti, Nicola, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, Valerio, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, Jp, Wang, Lq, Wang, Ql, Wang, Rs, Wang, X, Wang, Zx, Weng, Zl, Whitman, K, Wienkenhöver, J, Wu, H, Xia, X, Xie, M, Xie, S, Xiong, Rq, Xin, Gm, Xu, Ns, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Qh, Yi, H, Yu, Yj, Yu, Zq, Zeissler, S, Zhang, Jh, Zhang, Mt, Zhang, Xb, Zhang, Z, Zheng, Zm, Zhuang, Hl, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, Pauluzzi, Michele, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Istituto Nazionale di Fisica Nucleare (INFN), Institute of Nanotechnology [Karlsruhe] (INT), Karlsruhe Institute of Technology (KIT), Jülich Aachen Research Alliance (JARA), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CERN [Genève], Istituto Nazionale di Fisica Nucleare, Sezione di Roma 3 (INFN, Sezione di Roma 3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), University of Turku, Università degli Studi di Trento (UNITN), Department of Applied Mathematics (MIT), Massachusetts Institute of Technology (MIT), INFN Sezione di Pisa (INFN Sezione di Pisa), University of Hawai'i [Honolulu] (UH), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Karlsruher Institut für Technologie (KIT), NASA Johnson Space Center (JSC), NASA, Département de Physique Nucléaire et Corpusculaire [Genève] (DPNC), Université de Genève (UNIGE), CNR Istituto di Geoscienze e Georisorse [Firenze] (IGG), Consiglio Nazionale delle Ricerche (CNR), University of Pisa - Università di Pisa, EWHA Womans University (EWHA), National Central University [Taiwan] (NCU), Institute of High Energy Physics (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), Shandong University, Yale University [New Haven], Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (INFN, Sezione di Bologna), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), AMS, Aguilar, M, Aisa, D, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, H, Cheng, G, Cheng, L, Chikanian, A, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Du, W, Duranti, M, D’Urso, D, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, Kunz, S, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lomtadze, T, Lu, M, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Morescalchi, L, Mott, P, Müller, M, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pedreschi, E, Pensotti, S, Pereira, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, X, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, S, Schuckardt, D, von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Wang, L, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Wu, H, Xia, X, Xie, M, Xie, S, Xiong, R, Xin, G, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, J, Zhang, M, Zhang, X, Zhang, Z, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, M. Aguilar, D. Aisa, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. d. Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casau, V. Cascioli, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, A. Chikanian, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, Z. Cui, M. Dai, C. Delgado, S. D. Torre, M. B. Demirkoz, L. Derome, S. D. Falco, L. D. Masso, F. Dimiccoli, C. Diaz, P. v. Doetinchem, W. J. Du, M. Duranti, D. D'Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. Garcia, R. Garcia-Lopez, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, T. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, S. Kunz, G. L. Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, T. Lomtadze, M. J. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, A. Malinin, C. Mana, J. Marin, T. Martin, G. Martinez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Muller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nune, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomare, M. Paniccia, A. Papi, E. Pedreschi, S. Pensotti, R. Pereira, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodriguez, S. Rosier-Lee, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandwei, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, D. Schuckardt, A. S. von, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, S. C. C., S. M. Ting, N. Tomassetti, J. Torsti, C. Turkoglu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhover, H. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, and C. Zurbach

Subjects
ASTROPHYSICS, Astrophysics and Astronomy, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, Positron spectrum, General Physics and Astronomy, Cosmic ray, Electron, ddc:500.2, Space mission, Nuclear physics, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Radiative flux, Physics and Astronomy (all), FIS/05 - ASTRONOMIA E ASTROFISICA, Positron, Alpha Magnetic Spectrometer, ddc:550, Dark matter, Positron emission, AMS, Cosmic rays, electron flux, positron flux, international space station, Cosmic rays, Physics, Spectral index, Range (particle radiation), ta115, POSITRONS, ELECTRONS, FIS/01 - FISICA SPERIMENTALE, High Energy Physics::Experiment, COSMIC RAYS, ELECTRONS, POSITRONS, AMS, Electron spectrum, Astroparticle physics, Astrophysics - High Energy Astrophysical Phenomena, Particle Physics - Experiment
Abstract

International audience; Precision measurements by the Alpha Magnetic Spectrometer on the International Space Station of the primary cosmic-ray electron flux in the range 0.5 to 700 GeV and the positron flux in the range 0.5 to500 GeV are presented. The electron flux and the positron flux each require a description beyond a single power-law spectrum. Both the electron flux and the positron flux change their behavior at∼30GeV but the fluxes are significantly different in their magnitude and energy dependence. Between 20 and 200 GeV the positron spectral index is significantly harder than the electron spectral index. The determination of the differing behavior of the spectral indices versus energy is a new observation and provides important information on the origins of cosmic-ray electrons and positrons.

Published
2014
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91. Deep Learning and Numerical Analysis for Bladder Outflow Obstruction and Detrusor Underactivity Diagnosis in Men: A Novel Urodynamic Evaluation Scheme.

Author

Mei H, Wang Z, Zheng Q, Jiao P, Lv S, Liu X, Chen H, and Yang R

Subjects
Humans, Male, Retrospective Studies, Middle Aged, Aged, Lower Urinary Tract Symptoms physiopathology, Lower Urinary Tract Symptoms diagnosis, Adult, Urinary Bladder physiopathology, Fourier Analysis, Deep Learning, Urodynamics, Urinary Bladder Neck Obstruction physiopathology, Urinary Bladder Neck Obstruction diagnosis, Urinary Bladder, Underactive physiopathology, Urinary Bladder, Underactive diagnosis
Abstract

Objectives: To automatically identify and diagnose bladder outflow obstruction (BOO) and detrusor underactivity (DUA) in male patients with lower urinary tract symptoms through urodynamics exam., Patients and Methods: We performed a retrospective review of 1949 male patients who underwent a urodynamic study at two institutions. Deep Convolutional Neural Networks scheme combined with a short-time Fourier transform algorithm was trained to perform an accurate diagnosis of BOO and DUA, utilizing five-channel urodynamic data (consisting of uroflowmetry, urine volume, intravesical pressure, abdominal pressure, and detrusor pressure). We used fivefold cross-validation, constructing training and internal test sets from 1725 patients from Renmin Hospital of Wuhan University (RHWU) at a 4:1 ratio, and used an independent external validation set consisting of 224 patients from The Central Hospital of Wuhan (TCHO) to build and evaluate the DI model. We further conducted subgroup analyses to provide a more detailed description of the AI model's interpretability regarding urodynamics., Results: The AUC scores of BOO and DUA, which were measured through the STFT-based deep learning method, were 0.945 ± 0.020 and 0.929 ± 0.039 in RHWU and 0.881 and 0.850 in TCHO, respectively. The diagnostic efficiency of other subgroup analyses and indicators was also effective., Conclusion: In this study, the proposed deep neural network combined with the short-time Fourier transform method is robust and feasible for interpreting the results of urodynamics in men and has the potential for application to assist clinicians in real clinical settings., (© 2025 The Author(s). Neurourology and Urodynamics published by Wiley Periodicals LLC.)

Published
2025
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92. Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta-Analysis of Randomized Controlled Trials.

Author

Jin Z, Tang Y, Huang H, Chen L, Zhang Z, Ma T, Wang Z, Su H, Zhou H, Lv S, and Tong P

Subjects
Humans, Physical Therapy Modalities, Arthroplasty, Replacement, Knee rehabilitation, Randomized Controlled Trials as Topic, Network Meta-Analysis as Topic
Abstract

Objective: The rehabilitation methods after total knee arthroplasty (TKA) can affect the recovery of complications and joint function, and the selection and comparison of rehabilitation methods after TKA still need further research., Methods: A comprehensive search of five databases and two clinical trial registration platforms was conducted from inception through March 31, 2024, and conducted to identify eligible randomized controlled trials (RCTs). We extracted the required data according to the Cochrane Handbook for Systematic Reviews of Interventions. Finally, 32 trials involving 2292 patients were included, the mean age of the enrolled patients was ~69.10 years, the sex ratio of males was (31.6%), and the longest follow-up time was 2 years. And we have summarized nine rehabilitation intervention measures: conventional physical therapy (CPT), cryotherapy, thermal therapy (TT), acupuncture, hydrotherapy, neuromuscular training (NT), electrotherapy, continuous passive motion (CPM), continuous active motion (CAM). And use the range of motion (ROM), visual analog scale (VAS), Western Ontario and McMaster Universities osteoarthritis index (WOMAC) as the outcome measure to evaluate the effectiveness of various interventions. A Bayesian network meta-analysis (NMA) was carried out for calculating standardized mean difference (SMD) and the surface under cumulative ranking curve (SUCRA) of improvement of knee joint function after TKA by different rehabilitation methods., Result: After treatment, the ROM results showed that cryotherapy, electrotherapy, and NT had better therapeutic effects. Among them, cryotherapy (WMD = 10.3, 95% CI 1.63-18.2) had a significant therapeutic effect. In terms of VAS, NT and TT showed good therapeutic effects. Among them, NT had a more significant therapeutic effect, while CAM had less effect. After treatment, in terms of WOMAC, TT, hydrotherapy, cryotherapy, and NT had better therapeutic effects. TT had the best therapeutic effect, while Hydrotherapy and Cryotherapy also had certain advantages., Conclusion: NT, TT, cryotherapy, hydrotherapy, and electrotherapy rehabilitation therapies have good therapeutic effects for TKA patients compared with other interventions. Among them, NT may be the best postoperative rehabilitation therapy., (© 2025 The Author(s). Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.)

Published
2025
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93. MMP8-mediated vascular remodeling in pulmonary hypertension.

Author

Deng X, You Y, Lv S, and Liu Y

Subjects
Humans, Animals, Mice, Dynamins metabolism, Dynamins genetics, Endothelial Cells metabolism, Endothelial Cells pathology, Male, Mice, Knockout, Pulmonary Artery pathology, Pulmonary Artery metabolism, Signal Transduction, Mice, Inbred C57BL, Vascular Remodeling, STAT1 Transcription Factor metabolism, STAT1 Transcription Factor genetics, Hypertension, Pulmonary pathology, Hypertension, Pulmonary metabolism, Hypertension, Pulmonary genetics, Matrix Metalloproteinase 8 metabolism, Matrix Metalloproteinase 8 genetics
Abstract

Pulmonary arterial hypertension (PAH) is a vascular remodeling disease that impacts the cardiopulmonary system. Due to the currently limited understanding of vascular remodeling, a cure for PAH remains elusive. This study highlights the critical role of the STAT1 (signal transducer and activator of transcription 1)/MMP8 (matrix metallopeptidase 8)/DRP1 (dynamin-related protein 1) axis in vascular remodeling and the pathogenesis of pulmonary hypertension. Notably, MMP8 is significantly elevated in pulmonary arterial endothelial cells and its levels correlate with the severity of the disease. MMP8 binds to and activates DRP1, inducing mitochondrial fragmentation and promoting a malignant phenotype of endothelial cells under hypoxic conditions. Moreover, MMP8 is tightly regulated by STAT1. The knockout of MMP8 attenuates chronic pulmonary vascular remodeling, and drugs targeting MMP8 alleviate pulmonary hypertension and enhance cardiac function. This study offers fresh insights into hypoxia-induced vascular remodeling, laying a theoretical foundation for countering vascular remodeling by directly regulating the STAT1/MMP8/DRP1 axis., Competing Interests: Declaration of competing interest No potential conflict of interest needs to be stated., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2025
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94. Isorhapontigenin alleviates acetaminophen-induced liver injury by promoting fatty acid oxidation.

Author

Zha H, Lv S, Hu Y, Xie Y, Wang L, Yang C, Li G, Gong S, Ping L, Zhu D, Wang J, Weng Q, He Q, and Wang J

Subjects
Animals, Male, Mice, Oxidative Stress drug effects, Liver metabolism, Liver drug effects, Liver pathology, Liver injuries, Apoptosis drug effects, Mice, Inbred C57BL, Stilbenes, Acetaminophen adverse effects, Chemical and Drug Induced Liver Injury metabolism, Chemical and Drug Induced Liver Injury drug therapy, Chemical and Drug Induced Liver Injury pathology, Fatty Acids metabolism, Oxidation-Reduction drug effects
Abstract

Acetaminophen (APAP) is a widely used analgesic and antipyretic medicine. It is frequently employed to alleviate pain and mitigate fever-related symptoms, but it can cause liver injury or even liver failure when overdosed. Isorhapontigenin, a compound derived from Chinese herbs and grapes, has been demonstrated to exhibit antioxidant and anti-inflammatory effects. This study focused on evaluating the effect of isorhapontigenin in alleviating APAP-induced liver injury. In the study, a single intraperitoneal administration of APAP was employed to induce liver injury, and isorhapontigenin was given orally 3 days before or 1 h after APAP administration. The results revealed that isorhapontigenin significantly mitigated liver injury by effectively inhibiting APAP-induced apoptosis, oxidative stress, and inflammation. Furthermore, transcriptomic RNA sequencing of liver tissues indicated that isorhapontigenin probably protected against APAP-induced liver injury by promoting fatty acid oxidation. Pharmacological experiments also demonstrated that isorhapontigenin treatment led to a significant reduction in triglyceride accumulation, increased ATP levels and direct fatty acid oxidation activity, as well as enhanced expression of proteins associated with fatty acid oxidation, including PPAR-α, PGC-1α, and CPT-1A. Moreover, the protective effects of isorhapontigenin against APAP-induced liver injury were abolished by a CPT-1A inhibitor, etomoxir. Notably, we found that combining isorhapontigenin with NAC (N-acetyl-L-cysteine) resulted in a more significant alleviation of APAP-induced liver injury compared to NAC alone. In conclusion, our study indicates that isorhapontigenin is a potential therapeutic strategy that works by regulating fatty acid oxidation to alleviate APAP-induced liver injury., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2025
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95. Increased COX6A2 Promotes Pancreatic β-Cell Apoptosis and Is Suppressed in Diabetic GK Rats After Roux-en-Y Gastric Bypass.

Author

Kong X, Yan D, Shao L, Li B, Lv S, Tu Y, Zhang Y, Shu X, Ying Y, and Ma X

Subjects
Animals, Rats, Electron Transport Complex IV metabolism, Electron Transport Complex IV genetics, Male, Signal Transduction physiology, Glucagon-Like Peptide 1 metabolism, Diabetes Mellitus, Experimental metabolism, Diabetes Mellitus, Experimental genetics, Insulin-Secreting Cells metabolism, Insulin-Secreting Cells pathology, Apoptosis genetics, Gastric Bypass
Abstract

Article Highlights: Cytochrome c oxidase subunit 6A2 (COX6A2) expression is increased in diabetic islets. Increased COX6A2 promotes β-cell apoptosis via modulation of cyclophilin D-mediated cytochrome c release from mitochondria to the cytoplasm. Carbohydrate-responsive element-binding protein epigenetically regulates COX6A2 expression in β-cells. Roux-en-Y gastric bypass reduces COX6A2 expression by regulating the glucagon-like peptide 1/cAMP-dependent protein kinase/carbohydrate-responsive element-binding protein signaling pathway., (© 2024 by the American Diabetes Association.)

Published
2025
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96. A structure-based approach to discover a potential isomerase Pin1 inhibitor for cancer therapy using computational simulation and biological studies.

Author

Wang W, Jiang Q, Tao J, Zhang Z, Liu G, Qiu B, Hu Q, Zhang Y, Xie C, Song J, Jiang G, Zhong H, Zou Y, Li J, and Lv S

Subjects
Humans, Apoptosis drug effects, Neoplasms drug therapy, Cell Survival drug effects, Molecular Structure, Structure-Activity Relationship, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Molecular Docking Simulation, Cell Proliferation drug effects, Drug Discovery, NIMA-Interacting Peptidylprolyl Isomerase antagonists & inhibitors, NIMA-Interacting Peptidylprolyl Isomerase metabolism, Enzyme Inhibitors pharmacology, Enzyme Inhibitors chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry
Abstract

Peptidyl-prolyl cis/trans isomerase Pin1 occupies a prominent role in preventing the development of certain malignant tumors. Pin1 is considered a target for the treatment of related malignant tumors, so the identification of novel Pin1 inhibitors is particularly urgent. In this study, we preliminarily predicted eight candidates from FDA-approved drug database as the potential Pin1 inhibitors through virtual screening combined with empirical screening. Therefore, we selected these eight candidates and tested their binding affinity and inhibitory activity against Pin1 using fluorescence titration and PPIase activity assays, respectively. Subsequently, we found that four FDA-approved drugs showed good binding affinities and inhibition effects. In addition, we also observed that bexarotene can reduce cell viability in a dose-dependent and time-dependent manner and induce apoptosis. Finally, we inferred that residues K63, R68 and R69 are important in the binding process between bexarotene and Pin1. All in all, repurposing of FDA-approved drugs to inhibit Pin1 may provide a promising insight into the identification and development of new treatments for certain malignant tumors., Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2025
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97. Associations of Muscle-Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study.

Author

Lan Y, Ke Y, Sun D, Pei P, Yang L, Chen Y, Du H, Lv S, Barnard M, Chen J, Chen Z, Lv J, Li L, and Yu C

Subjects
Humans, Female, Male, Middle Aged, Prospective Studies, Adult, Aged, China epidemiology, Aged, 80 and over, Respiratory Tract Diseases epidemiology, Respiratory Tract Diseases etiology, Muscle, Skeletal physiopathology, Muscle Strength physiology, East Asian People, Hand Strength physiology
Abstract

Background: There is limited evidence about the association of muscle mass, strength and quality with respiratory disease, especially in Chinese populations. We aimed to comprehensively examine such associations and identify better metrics with more clinical and public health relevance., Methods: We conducted a prospective cohort study based on data from the second resurvey of the China Kadoorie Biobank (CKB) study in participants with no prevalent respiratory disease or cancer. Arm muscle quality was calculated as the ratio of grip strength to arm muscle mass. Low muscle mass, grip strength and arm muscle quality were defined as the sex-specific lowest quintiles of corresponding variables. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for respiratory disease., Results: In total, 17 510 participants aged 38-88 (65.4% women; mean age 57.8 ± 9.6) were enrolled in 2013-2014 and followed up until 31 December 2018. During a median follow-up of 4.82 years, 1346 participants developed respiratory disease. After adjustment for sociodemographic characteristics, lifestyle factors and medical histories, the elevated HR of respiratory disease was 1.31 (1.14-1.51) for low grip strength and 1.25 (1.09-1.44) for low arm muscle quality. Grip strength and arm muscle quality exhibited a linearly inverse association between respiratory disease (p = 0.137 and 0.102), with each standard deviation (SD) decrease in grip strength and arm muscle quality associated with a 22% (95% CI: 11%-34%) and 14% (95% CI: 7%-22%) increased risk of respiratory disease. No association was found for low total muscle mass index and low appendicular muscle mass index., Conclusion: Low grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle-related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials., (© 2025 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC.)

Published
2025
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98. Design optimization of bimetal-modified biochar for enhanced phosphate removal performance in livestock wastewater using machine learning.

Author

Fu W, Yao X, Zhang L, Zhou J, Zhang X, Yuan T, Lv S, Yang P, Fu K, Huo Y, and Wang F

Subjects
Animals, Adsorption, Water Pollutants, Chemical isolation & purification, Hydrogen-Ion Concentration, Metals chemistry, Charcoal chemistry, Machine Learning, Phosphates chemistry, Wastewater chemistry, Livestock, Water Purification methods
Abstract

Mg-modified biochar shows high adsorption performance under weakly acidic and neutral water conditions. However, its phosphate removal efficiency markedly decreases in naturally alkaline wastewater, such as that released in livestock farming (anaerobic wastewater with a high phosphate concentration). This research employed six machine learning models to predict and optimize the phosphate removal performance of bimetal-modified biochar (i.e., Mg-Ca/Al/Fe/La) to develop material design strategies suitable for achieving high removal efficiency in alkaline wastewater. Random forest, gradient boosting regressor, and extreme gradient boosting models achieved high prediction accuracy (R 2  > 0.98). Model predictions and experimental validations indicated that Mg-Ca-modified biochar still maintained high adsorption capacity under acidic conditions and could effectively realize phosphate adsorption under alkaline conditions, with a removal rate of 99.33 %. Overall, this research focuses on material performance optimization using machine learning, offering insights and methods for developing biochar materials for practical water-treatment applications., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Published
2025
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99. Jack Surgery: Reconstructing Collapsed Femoral Head in Association Research Circulation Osseous Stage III Osteonecrosis: A Series of 13 Cases.

Author

Zhong Y, Gong Y, Lv S, Du W, Liu X, Zhang J, and Tong P

Subjects
Humans, Male, Adult, Female, Retrospective Studies, Middle Aged, Osteotomy methods, Bone Transplantation methods, Young Adult, Pain Measurement, Femur Head Necrosis surgery, Femur Head Necrosis etiology
Abstract

Objective: According to Association Research Circulation Osseous (ARCO) staging, patients with ARCO III osteonecrosis of femoral head (ONFH) have joint pain and dysfunction due to the collapse of femoral head. Current hip preservation surgeries are not satisfying in the treatment of ARCO III ONFH according to the long-term follow-up. In our practice, we focused on reconstructing femoral head by restoring the round shape of femoral head and subsequently preventing the development of hip arthritis. To lift the collapsed femoral head and postpone the potential total hip arthroplasty, we practiced Jack surgery, combining surgical hip dislocation, removal of necrotic bone, impaction bone grafting, and lifting the cartilage of femoral head., Methods: From February 2019 to July 2022, 13 patients (15 hips) who received Jack surgery in the research center were included in this retrospective study. Follow-up was conducted every 3 months after surgery for imaging and clinical evaluation. The differences between visual analogue scale (VAS) and Harris hip score (HSS) before and after surgery were compared to observe whether the femoral head collapsed and whether osteotomy healed after surgery. Severe collapse of the femoral head ( > 2 mm) or receiving total hip arthroplasty (THA) was defined as failure of hip preservation therapy. An Independent sample t-test was used to compare the data, and the chi-square test was used for categorical data., Results: All the 13 patients successfully completed the surgery and were followed up. The average time of follow-up was 36.46 ± 16.87 months (ranging from 14 to 66 months). HSS was assessed 12 months after surgery: excellent in 1 patient with 1 hip; good in 9 patients with 11 hips; modest in 3 patients with 3 hips. To the last follow-up, the VAS scores decreased from 6.17 ± 1.02 to 2.08 ± 0.90 (p < 0.001), HSS increased from 46.69 ± 4.15 to 89.77 ± 2.86 (p < 0.001). No deep infection, fracture, osteotomy nonunion, nerve injury, deep vein thrombosis, pulmonary embolism, or other complications occurred., Conclusion: For young patients with ONFH of ACRO III, this surgical technique can effectively restore the original shape of the femoral head and achieve satisfactory hip function in the short term. The mechanism is similar to jacking the roof of a house; thus, we named it "Jack surgery"., (© 2024 The Author(s). Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.)

Published
2025
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100. Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review).

Author

Lv S and Luo C

Subjects
Humans, Animals, Antioxidants therapeutic use, Acetylcysteine therapeutic use, Acetylcysteine pharmacology, Lipid Peroxidation, Selenium therapeutic use, Selenium metabolism, Ferroptosis drug effects, Schizophrenia metabolism, Schizophrenia drug therapy, Schizophrenia pathology, Oxidative Stress, Iron metabolism
Abstract

Schizophrenia, a complex psychiatric disorder, presents with multifaceted symptoms and important challenges in treatment, primarily due to its pathophysiological complexity, which involves oxidative stress and aberrant iron metabolism. Recent insights into ferroptosis, a unique form of iron‑dependent cell death characterized by lipid peroxidation and antioxidant system failures, open new avenues for understanding the neurobiological foundation of schizophrenia. The present review explores the interplay between ferroptosis and schizophrenia, emphasizing the potential contributions of disrupted iron homeostasis and oxidative mechanisms to the pathology and progression of this disease. The emerging evidence linking ferroptosis with the oxidative stress observed in schizophrenia provides a compelling narrative for re‑evaluating current therapeutic strategies and exploring novel interventions targeting these molecular pathways, such as the glutathione peroxidase 4 pathway and the ferroptosis suppressor protein 1 pathway. By integrating recent advances in ferroptosis research, the current review highlights innovative therapeutic potentials, including N‑acetylcysteine, selenium, omega‑3 fatty acids and iron chelation therapy, which could address the limitations of existing treatments and improve clinical outcomes for individuals with schizophrenia.

Published
2025
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