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54. OP0112 THE EVER-LARGEST ASIAN GWAS FOR SYSTEMIC SCLEROSIS AND TRANS-POPULATION META-ANALYSIS IDENTIFIED SEVEN NOVEL LOCI AND A CANDIDATE CAUSAL SNP IN A CIS-REGULATORY ELEMENT OF THE FCGR REGION

Author

Y. Ishikawa, N. Tanaka, Y. Asano, M. Kodera, Y. Shirai, M. Akahoshi, M. Hasegawa, T. Matsushita, S. Kazuyoshi, S. Motegi, H. Yoshifuji, A. Yoshizaki, T. Kohmoto, K. Takagi, A. Oka, M. Kanda, Y. Tanaka, Y. Ito, K. Nakano, H. Kasamatsu, A. Utsunomiya, A. Sekiguchi, H. Niro, M. Jinnin, K. Makino, T. Makino, H. Ihn, M. Yamamoto, C. Suzuki, H. Takahashi, E. Nishida, A. Morita, T. Yamamoto, M. Fujimoto, Y. Kondo, D. Goto, T. Sumida, N. Ayuzawa, H. Yanagida, T. Horita, T. Atsumi, H. Endo, Y. Shima, A. Kumanogoh, J. Hirata, N. Otomo, H. Suetsugu, Y. Koike, K. Tomizuka, S. Yoshino, X. Liu, S. Ito, K. Hikino, A. Suzuki, Y. Momozawa, S. Ikegawa, O. Ishikawa, K. Takehara, T. Torii, S. Sato, Y. Okada, T. Mimori, F. Matsuda, K. Matsuda, I. Imoto, K. Matsuo, M. Kuwana, Y. Kawaguchi, K. Ohmura, and C. Terao

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundGenome-wide association studies (GWASs) have identified 29 disease-associated single nucleotide polymorphisms (SNPs) for systemic sclerosis (SSc) in non-human leukocyte antigen (HLA) regions (1-7). While these GWASs have clarified genetic architectures of SSc, study subjects were mainly Caucasians limiting application of the findings to Asians.ObjectivesThe study was conducted to identify novel causal variants for SSc specific to Japanese subjects as well as those shared with European population. We also aimed to clarify mechanistic effects of the variants on pathogenesis of SSc.MethodsA total of 114,108 subjects comprising 1,499 cases and 112,609 controls were enrolled in the two-staged study leading to the ever-largest Asian GWAS for SSc. After applying a strict quality control both for genotype and samples, imputation was conducted using the reference panel of the phase 3v5 1,000 genome project data combined with a high-depth whole-genome sequence data of 3,256 Japanese subjects. We conducted logistic regression analyses and also combined the Japanese GWAS results with those of Europeans (6) by an inverse-variance fixed-effect model. Polygenicity and enrichment of functional annotations were evaluated by linkage disequilibrium score regression (LDSC), Haploreg and IMPACT programs. We also constructed polygenic risk score (PRS) to predict SSc development.ResultsWe identified three (FCRLA-FCGR, TNFAIP3, PLD4) and four (EOMES, ESR1, SLC12A5, TPI1P2) novel loci in Japanese GWAS and a trans-population meta-analysis, respectively. One of Japanese novel risk SNPs, rs6697139, located within FCGR gene clusters had a strong effect size (OR 2.05, P=4.9×10-11). We also found the complete LD variant, rs10917688, was positioned in cis-regulatory element and binding motif for an immunomodulatory transcription factor IRF8 in B cells, another genome-wide significant locus in our trans-ethnic meta-analysis and the previous European GWAS. Notably, the association of risk allele of rs10917688 was significant only in the presence of the risk allele of the IRF8. Intriguingly, rs10917688 was annotated as one enhancer-related histone marks, H3K4me1, in B cells, implying that FCGR gene(s) in B cells may play an important role in the pathogenesis of SSc. Furhtermore, significant heritability enrichment of active histone marks and a transcription factor C-Myc were found in B cells both in European and Japanese populations by LDSC and IMPACT, highlighting a possibility of a shared disease mechanism where abnormal B-cell activation may be one of the key drivers for the disease development. Finally, PRS using effects sizes of European GWAS moderately fit in the development of Japanese SSc (AUC 0.593), paving a path to personalized medicine for SSc.ConclusionOur study identified seven novel susceptibility loci in SSc. Downstream analyses highlighted a novel disease mechanism of SSc where an interactive role of FCGR gene(s) and IRF8 may accelerate the disease development and B cells may play a key role on the pathogenesis of SSc.References[1]F. C. Arnett et al. Ann Rheum Dis, 2010.[2]T. R. Radstake et al. Nat Genet, 2010.[3]Y. Allanore et al. PLoS Genet, 2011.[4]O. Gorlova et al. PLoS Genet, 2011.[5]C. Terao et al. Ann Rheum Dis, 2017.[6]E. López-Isac et al. Nat Commun, 2019.[7]W. Pu et al. J Invest Dermatol, 2021.Disclosure of InterestsNone declared

Published
2022
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55. POS0794 PREGNANCY AND CHILDBIRTH IN TAKAYASU ARTERITIS IN JAPAN – A NATIONWIDE RETROSPECTIVE STUDY

Author

T. Miyamae, Y. Manabe, T. Sugihara, N. Umezawa, H. Yoshifuji, N. Tamura, Y. Abe, S. Furuta, M. Kato, T. Kumagai, K. Nakamura, H. Nagafuchi, J. Ishizaki, N. Nakano, T. Atsumi, K. Karino, K. Amano, T. Kurasawa, S. Ito, R. Yoshimi, N. Ogawa, S. Banno, T. Naniwa, A. Hara, S. Hirahara, H. A. Uchida, Y. Onishi, Y. Murakawa, Y. Komagata, Y. Nakaoka, and M. Harigai

Subjects
Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract

BackgroundTakayasu arteritis (TAK), a granulomatous large vessel vasculitis, mainly involves the aorta and its proximal branches and commonly occurs in young females. However, studies of pregnancy in women with TAK are sparse and limited, probably due to the rarity of the disease.ObjectivesThe purpose of this study was to understand the status quo of medical treatments of the primary disease and outcomes of pregnancy in patients with TAK, and birth outcomes of the children in Japan.MethodsPatients with TAK who conceived after the onset of the disease and were managed at medical facilities participating in the Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) were retrospectively enrolled in this study. The following information was collected from patients who had a live-born baby: age at diagnosis of TAK, disease classification, age at delivery, treatments before and during pregnancy, complications during pregnancy, birth outcomes of the children, and changes in disease activity during pregnancy and after delivery.ResultsFifty-one cases and 69 pregnancies from 19 ethics committee-approved centers were enrolled during the study period 2019–2021. Of these, 49 cases and 66 pregnancies (95.7%) resulted in delivery and live-born babies. The Numano classification of the 49 cases was as follows: type I, 11; type IIa, 15; type IIb,12; type III, 1; type IV, 1; type V, 9; with type IIa being the most common. The age of diagnosis was 22 years (13–37 years, year of diagnosis 1965–2017), the median age of the delivery of 66 pregnancies was 31 years (year of delivery 1969-2021), and the median duration of illness at delivery was nine years. There were 34 planned pregnancies (51.5%, including four pregnancies by artificial insemination/ovulation induction). Preconception therapy included prednisolone (PSL) in 51 pregnancies (77.3%, median dose 7.5 mg (range 4–30 mg)/day), immunosuppressive drugs in 18 pregnancies (27.3%, azathioprine 8, tacrolimus 7, methotrexate 4, cyclosporin A 1, and colchicine 1), biologics in 12 pregnancies (18.1%, infliximab 6, tocilizumab 5, and adalimumab 1), antihypertensive drugs in 5 pregnancies (7.6%). Surgical treatment had been performed before pregnancy in 6 cases (aortic root replacement 2, subclavian artery dilatation 1, subclavian artery bypass 1, subclavian artery stenting 1, and ascending aorta semicircular artery replacement 1). Medications used during the course of pregnancy included PSL in 48 pregnancies (72.7%, median dose 8 mg (range 4–30 mg)/day, increased in 13 pregnancies, decreased in 1 pregnancy), immunosuppressants in 13 pregnancies (19.7%, azathioprine 6, tacrolimus 6, and cyclosporin A 1), biologics 9 pregnancies (13.6%, infliximab 4, tocilizumab 4, and adalimumab 1). Immunosuppressants and biologics were discontinued in five and four pregnancies after conception. Complications during pregnancy were observed in 20 pregnancies (30.3%), with hypertension being the most common. Complications related to TAK or its treatment were severe infections in two pregnancies and aneurysm enlargement due to increased circulating plasma volume in one pregnancy. Aortic arch replacement was performed after delivery for the latter case. Relapse of TAK was observed in 4 pregnancies (6.1%) during pregnancy and in 8 pregnancies (12.1%) after delivery. One pregnancy resulted in restenosis of subclavian artery for which dilatation procedure was performed prior to the pregnancy. There were 13/66 (19.7%) preterm infants and 17/59 (28.8%) low birth weight infants; all but one had a birth weight of more than 2,000 g and no had serious postnatal abnormalities. Forty-three (82.7%) of the 52 confirmed infants were breastfeed fully or mixed.ConclusionMost of the pregnancies in patients with TAK were successfully delivered while they had low disease activity at a dose of less than 10 mg/day of PSL. Relapse occurred during pregnancy and after delivery in some cases. The babies tended to have low birth weight, but 82.7% of them were breastfed without serious complications.Disclosure of InterestsTakako Miyamae: None declared, Yusuke Manabe: None declared, takahiko sugihara Speakers bureau: TS has received honoraria from Abbvie Japan Co., Ltd., AsahiKASEI Co., Ltd., Astellas Pharma Inc., Ayumi Pharmaceutical, Bristol Myers Squibb K.K., Chugai Pharmaceutical Co., Ltd., Eli Lilly Japan K.K., Mitsubishi-Tanabe Pharma Co., Ono Pharmaceutical, Pfizer Japan Inc., Takeda Pharmaceutical Co. Ltd., and UCB Japan Co., Grant/research support from: TS has received research grants from AsahiKASEI Co., Ltd., Daiichi Sankyo., Chugai Pharmaceutical Co., Ltd., and Ono Pharmaceutical., Natsuka Umezawa: None declared, Hajime Yoshifuji Speakers bureau: HY has received lecture fees from Janssen and Chugai., Naoto Tamura: None declared, Yoshiyuki Abe: None declared, Shunsuke Furuta Speakers bureau: Chugai Pharmaceutical Co.,Ltd.DaiichiSankyo Co.,Ltd.Asahi-Kasei Pharma Corporation, Manami Kato: None declared, Takashi Kumagai: None declared, Kaito Nakamura: None declared, Hiroko Nagafuchi: None declared, Jun Ishizaki: None declared, Naoko Nakano: None declared, Tatsuya Atsumi Speakers bureau: Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., Astellas Pharma Inc., Takeda Pharmaceutical Co., Ltd., Pfizer Inc., AbbVie Inc., Eisai Co. Ltd., Daiichi Sankyo Co., Ltd., Bristol-Myers Squibb Co., UCB Japan Co. Ltd., Eli Lilly Japan K.K., Novartis Pharma K.K., Eli Lilly Japan K.K., Kyowa Kirin Co., Ltd.,TAIHO PHARMACEUTICAL CO., LTD., Consultant of: AstraZeneca plc., MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., Pfizer Inc., AbbVie Inc., ONO PHARMACEUTICAL CO. LTD.,Novartis Pharma K.K., Nippon Boehringer Ingelheim Co., Ltd., Grant/research support from: Astellas Pharma Inc., TAIHO PHARMACEUTICAL CO., LTD.AbbVie Inc., Nippon Boehringer Ingelheim Co., Ltd.,Takeda Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co. Ltd., Otsuka Pharmaceutical Co., Ltd. and Pfizer Inc. Alexion Inc., TEIJIN PHARMA LIMITED., Kohei Karino: None declared, Koichi Amano Speakers bureau: AbbVie GK, Asahi-Kasei Pharma, Astellas, Chugai Pharmaceutical Co.Ltd., Eisai, Eli Lilly, GlaxoSmithKlein, Janssen Pharma, Pfizer Japan, Grant/research support from: Asahi-Kasei Pharma,Chugai Pharmaceutical Co.Ltd., Takahiko Kurasawa: None declared, Shuichi Ito: None declared, Ryusuke Yoshimi: None declared, Noriyoshi Ogawa: None declared, Shogo Banno: None declared, Taio Naniwa Speakers bureau: Chugai, Tanabe, Abbbvie, Eisai, Grant/research support from: Chugai, Tanabe, Abbbvie, Eisai, Satoshi Ito Speakers bureau: SI has received speaker’s fees from pharmaceutical companies., Akinori Hara: None declared, Shinya Hirahara: None declared, Haruhito A. Uchida: None declared, Yasuhiro Onishi: None declared, Yohko Murakawa Speakers bureau: Astellas, UCB, Chugai, AbbVie, Grant/research support from: Chugai, AbbVie, Yoshinori Komagata: None declared, Yoshikazu Nakaoka: None declared, Masayoshi Harigai Speakers bureau: MH has received speaker’s fee from AbbVie Japan GK, Ayumi Pharmaceutical Co., Boehringer Ingelheim Japan, Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Janssen Pharmaceutical K.K., Kissei Pharmaceutical Co., Ltd., Novartis Japan, Pfizer Japan Inc., Mitsubishi Tanabe Pharma Co., Teijin Pharma Ltd and UCB Japan., Consultant of: MH is a consultant for AbbVie, Boehringer-Ingelheim, Kissei Pharmaceutical Co., Ltd., and Teijin Pharma.

Published
2022
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56. Fundamental Physics with Cooled Radioactive Atoms

Author

Hirokazu Kawamura, Kenichi Harada, A. Uchiyama, Masatoshi Itoh, Junji Hisano, Yoshiro Takahashi, Takatoshi Aoki, Yasuhiro Sakemi, S. Ito, Atsushi Hatakeyama, and Takeshi Inoue

Subjects
Physics, Fundamental physics, Atomic physics
Published
2021
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57. Lack of association between a disease-susceptible single-nucleotide polymorphism, rs2230926 of TNFAIP3, and tumour necrosis factor inhibitor therapeutic failure in Japanese patients with rheumatoid arthritis

Author

F Hirano, Yukihiko Saeki, Yasutaka Okita, Shiro Ohshima, S Ito, Shigeto Tohma, E. Suematsu, M Katayama, Hirokazu Takaoka, Y. Harada, S. Teshigawara, Y. Suenaga, Akiko Okamoto, Hidetoshi Matsuoka, Daijiro Kabata, M. Yoshimura, Chikako Udagawa, Kentaro Kuzuya, Y Yoshida, Shigeru Yoshizawa, Koichiro Ohmura, K. Takahi, K Isoda, Eri Oguro, A. Taura, and Toshihiro Matsui

Subjects
030203 arthritis & rheumatology, business.industry, Immunology, Tumor Necrosis Factor alpha-Induced Protein 3, General Medicine, medicine.disease, TNFAIP3, Infliximab, Etanercept, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Rheumatology, Rheumatoid arthritis, medicine, Adalimumab, Immunology and Allergy, 030212 general & internal medicine, business, B cell, medicine.drug
Abstract

Biological disease-modifying anti-rheumatic drugs (bDMARDs) against pathogenic proinflammatory cytokines and lymphocytes, such as tumour necrosis factor-α (TNF-α), interleukin-6, T cells and B cell...

Published
2020
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59. A129 CYP2C19 PHARMACOGENETIC TESTING IN PAEDIATRIC PATIENTS WITH EOSINOPHILIC ESOPHAGITIS INFLUENCES DOSING OF PROTON-PUMP-INHIBITORS AND RESPONSE TO THERAPY

Author

K A Bortolin, I Cohn, S Da Silva, S Ito, P Marcon, N Afzal, S Scodellaro, R Verstegen, and J Hulst

Abstract

Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder that can be treated with a proton pump inhibitor (PPI). Pharmacogenetics (PGx) is the study of how variations in an individual’s genome influences drug response. Genetic variation in the metabolism gene CYP2C19 can produce differences in enzyme activity which is known to be a contributing factor for therapeutic failure with PPI treatment. Use of 2nd generation PPI (rabeprazole) can be beneficial in some as this PPI is less effected by CYP2C19 metabolism. PGx has been studied in PPI therapy for peptic ulcer disease but has not been demonstrated in patients with EoE. Aims To describe the CYP2C19 metabolism in patients with EoE on PPI and to estimate the clinical utility of PGx testing in directing subsequent changes in therapy with improvement in remission rates. Methods Interim analyses of a single centre, non-interventional, ongoing descriptive pilot study investigating CYP2C19 metabolism in patients with EoE, as part of a larger PGx pilot study and EoE- AHEAD Registry Study at SickKids. Patients with EoE that were newly diagnosed and started PPI or those not in remission on current non-PPI therapy or not in remission on dose PPI (2 mg/kg/day, max 30 mg lansoprazole BID) were included. Active disease was defined as a peak eosinophil count >15/hpf. Results 37 patients met the inclusion criteria with completed PGx test; mean age was 13 years, 29(78%) were male, and 13(35%) had concurrent atopic disease. PGx testing showed that 12(32%) and 4(11%) were rapid (RM) and ultrarapid metabolizers (URM) respectively (Fig.1), which is significantly higher than the population average. Of this subgroup, 9 started rabeprazole, 3 had a lansoprazole dose increase, and 4 had no changes. Overall, changes in therapy based on PGx testing were made in 29(78%) patients, 8 are awaiting follow-up (Fig 2). Currently, the patients with available repeat biopsy results after PGx test-guided therapy changes is limited due COVID-19 related delays in endoscopies. Conclusions The preliminary findings of our study using PGx to guide PPI dosing in pediatric patients with EoE demonstrate that PGx test results lead to a change in clinical management in most patients. In RM and URM, PGx results trigger an adjustment of PPI dose or type could lead to earlier disease remission in PPI-responsive patients, thereby optimizing PPI efficacy. PGx may support dose reduction in poor metabolizers aiming to avoid long-term adverse events. Further correlation with endoscopy and histology findings of patients after PGx-guided therapy changes will follow. Furthermore, it is important to examine if CYP2C19 variant information available before PPI therapy further streamlines an initial phase of the treatment. Funding Agencies Dr. Marcon: J Garfield Campbell Fund, Dr. Hulst: Start-up Funds from the Department of Pediatrics at SickKids

Published
2022
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62. The XtaLAB Synergy-ED: progress and latest results

Author

F. White, R. Bücker, M. Meyer, M. Jasnowski, A. Yamano, S. Ito, J. Ferrara, E. Okunishi, and Y. Aoyama

Subjects
Inorganic Chemistry, Structural Biology, General Materials Science, Physical and Theoretical Chemistry, Condensed Matter Physics, Biochemistry
Published
2022
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63. Discourse Analysis of Japanese 'Black Companies'

Author

S. Ito, Akira Kimata, T. Nakamura, N. Teramoto, and M. Takahashi

Subjects
Computer Networks and Communications, business.industry, Process (engineering), Discourse analysis, Social environment, Power relations, Public relations, Labor relations, Power (social and political), Work (electrical), Hardware and Architecture, Sociology, business, Software
Abstract

Issues concerning Black Companies have been extensively discussed in Japan recently. This paper aims to understand how discourses on Black Companies have been constructed and altered within the Japanese social context. To achieve this, we conducted discourse analysis using the case of Dentsu Inc., focusing especially on the multi-levels of discourse and power relations. We find that the process of power emergence in Black Companies and of values relating to the ethic of hard work on the part of employees relate to three levels of discourse: micro-discourse, meso-discourse and macro-discourse. This paper contributes to discourse studies by establishing that one discourse emerges under the influence of other discourses. As a practical contribution, this finding will assist those struggling with injustices in their organisation by enabling them to change their difficult situations via involvement with various discourses.

Published
2018
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65. U.S. Efforts in Support of Examinations at Fukushima Daiichi- November 2020 Meeting Notes with Updated Information Requests

Author

Shinya Mizokami, T. Okamoto, S. Kraft, F. Bolger, H. Tanoue, D. Luxat, R. Gauntt, W. Kikuchi, Richard M. Wachowiak, M. Corradini, A. Nakayoshi, P. Ellison, K. Robb, J. Gabor, W. Luangdilok, M. Plys, M. T. Farmer, L. Albright, M. Yasui, P. McMinn, M. Cibula, P. Whiteman, R. Linthicum, Chan Y. Paik, M. Kurata, S. Basu, K. Kirkland, S. Ito, N. Andrews, H. Hoshi, J. Rempe, K. Klass, M. Taira, T. Kobayashi, R. Kojo, R. Bunt, J. Nakano, K. Voelsing, K. Iwanaga, S. Koyama, P. Amway, M. Nudi, B. Williamson, R. Martin, and T. Washiya

Subjects
Fukushima daiichi, Political science, Library science
Published
2021
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67. Determination of the phase coherence length of PdCoO2 nanostructures by conductance fluctuation analysis

Author

Jochen Mannhart, S. Ito, Atsushi Tsukazaki, P. Bredol, Hisashi Inoue, and T. Harada

Subjects
Physics, Nanostructure, Strongly Correlated Electrons (cond-mat.str-el), Condensed Matter - Mesoscale and Nanoscale Physics, Condensed matter physics, Mean free path, Scattering, FOS: Physical sciences, Conductance, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Condensed Matter - Strongly Correlated Electrons, Phase coherence, Phase (matter), Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, Thin film, 010306 general physics, 0210 nano-technology, Universal conductance fluctuations
Abstract

The two-dimensional layered compound PdCoO$_2$ is one of the best oxide conductors, providing an intriguing research arena opened by the long mean free path and the very high mobility of ~51000 cm2/Vs. These properties turn PdCoO$_2$ into a candidate material for nanoscale quantum devices. By exploring universal conductance fluctuations originating at nanoscale PdCoO$_2$ Hall-bar devices, we determined the phase coherence length of electron transport in c-axis oriented PdCoO$_2$ thin films to equal ~100 nm. The weak temperature dependence of the measured phase coherence length suggests that defect scattering at twin boundaries in the PdCoO$_2$ thin film governs phase breaking. These results suggest that phase coherent devices can be achieved by realizing the devices smaller than the size of twin domains, via refined microfabrication and suppression of twin boundaries., 6 pages, 5 figures

Published
2021
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68. Study of the normalized transverse momentum distribution of W bosons produced in pp¯ collisions at s=1.96 TeV

Author

Robert Hirosky, Joseph Haley, Wade Cameron Fisher, R. Van Kooten, V. A. Kuzmin, L. S. Vertogradov, M. D. Corcoran, A. Evdokimov, R. Demina, G. Gutierrez, Hongfang Liu, J. Orduna, L. Han, I. Ripp-Baudot, P. G. Mercadante, R. Bernhard, W. E. Cooper, F. Badaud, Arnaud Duperrin, A. D. Bross, P. Skubic, Petr Vokac, J. Franc, T. Nunnemann, B. Baldin, S. Desai, J. Snow, Y. Gershtein, U. Bassler, J. P. Negret, Lev Dudko, Lidija Zivkovic, E. W. Varnes, H. Hegab, V. Parihar, R. Luna-Garcia, Avto Kharchilava, T. Hoang, Alexander Khanov, Julie Managan Hogan, J. Sekaric, S. W. Youn, Ruchika Nayyar, J. K. Kraus, Y. T. Tsai, S. Atkins, Y. Ilchenko, G. Golovanov, D. Menezes, Michael Hildreth, N. Prokopenko, T. R. Wyatt, Per Jönsson, Jonathan Michael Hays, Suneel Dutt, H. T. Nguyen, Y. A. Yatsunenko, M. Merkin, Victor Daniel Elvira, A. Kumar, Maxim Perfilov, Brad Abbott, Pierre Petroff, H. G. Evans, S. Uzunyan, Aaron Dominguez, M. H.L.S. Wang, Jose Andres Garcia-Gonzalez, Sung Keun Park, I. Howley, Harald Fox, L. Suter, R. Magaña-Villalba, S. W. Cho, Gianluca Petrillo, Andrew Askew, Shabnam Jabeen, Jan Stark, S. Kermiche, V. Hynek, G. F. Chen, Y. N. Kharzheev, Jean-Arcady Meyer, L. Bagby, Y. Xie, A. Das, Amnon Harel, Gregorio Bernardi, D. Denisov, G. D. Alexeev, Flera Rizatdinova, H. Greenlee, I. A. Vasilyev, R. Illingworth, Martin Grunewald, K. M. Chan, P. Rubinov, Kristian Harder, L. Bellantoni, T. Head, K. Devaughan, Andreas Werner Jung, Todd Adams, Anthony Ross, Y. Fu, Milos Lokajicek, V. M. Abazov, V. Shary, Darren Price, H. L. Li, Thomas Ferbel, M. Prewitt, Lars Sonnenschein, S. Uvarov, S. J. De Jong, Gregory R. Snow, Liang Li, P. D. Grannis, P. N. Ratoff, Y. Peters, S. Greder, Cecilia Elena Gerber, D. Li, Raymond Brock, R. Beuselinck, D. Karmanov, Maksym Titov, M. Begalli, S. Caughron, Arnulf Quadt, P. C. Bhat, Alexander Grohsjean, Hua-Lei Yin, Darien Wood, D. V. Bandurin, D. Cutts, W. M. Lee, Elemer Nagy, J. F. Bartlett, J. K. Lim, Lev Uvarov, Mark Richard James Williams, Robert Kehoe, G. Ginther, C. P. Buszello, Marco Verzocchi, W. Ye, P. H. Garbincius, S. Choi, Sudhir Malik, A. L. Lyon, Ia Iashvili, A. V. Kozelov, Jianming Qian, Vladimir Gavrilov, Iain Alexander Bertram, Graham Savage, A. Melnitchouk, J. P. Agnew, S. Blessing, A. Brandt, I. Heredia-De La Cruz, Alice Bean, Ph. Lebrun, P. F. Ding, Elizaveta Shabalina, A. P. Heinson, A. K.A. Maciel, Frederic Deliot, Christopher George Tully, Robert J. McCarthy, A. Sanchez-Hernandez, Manjit Kaur, L. Welty-Rieger, Gordon Watts, N. Osman, Jakub Cúth, A. Patwa, Mikkel B. Johnson, V. V. Tokmenin, Fine Fiedler, Neeti Parashar, H. A. Neal, Volker Buescher, Vipin Bhatnagar, M. A. Pleier, J. Clutter, Q. Z. Li, J. M. Hauptman, A. A. Shchukin, Jean-Francois Grivaz, X. B. Bu, E. Kajfasz, D. R. Claes, Gavin Davies, K. Yip, I. Kiselevich, Mykola Savitskyi, A. Jonckheere, I. Razumov, M. Zielinski, Jason Dhia Mansour, A. B. Meyer, G. J. Grenier, Lei Feng, V. N. Evdokimov, M. Rominsky, A. Juste, A. Lobodenko, G. Alkhazov, Phillip Gutierrez, K. Soustruznik, Patrick Slattery, J. Weichert, Kenneth Bloom, J. T. Linnemann, B. C. Choudhary, M. Hohlfeld, Yuji Enari, N. K. Mondal, D. Boline, H. T. Diehl, Shangfeng Yang, M. Brochmann, Tianchi Zhao, Cecile Deterre, P. Neustroev, V. L. Malyshev, V. Simak, S. Bhatia, Sabine Lammers, J. L. Holzbauer, S. W. Lee, Meenakshi Narain, Y. Scheglov, John Hobbs, S. Chakrabarti, A. Boehnlein, Daria Zieminska, C. H. Wang, Xiaowen Lei, Don Lincoln, W. Geng, Jiaming Yu, Christian Schwanenberger, Thibault Guillemin, Mitchell Wayne, H. Schellman, J. M. Kohli, Christophe Royon, H. E. Fisk, G. Sajot, M. S. Jeong, Stefan Grünendahl, J. Ellison, S. Cihangir, Emilien Chapon, Y. Aushev, Fabrice Couderc, Kamil Augsten, M. R. Adams, S. Fuess, N. Khalatyan, T. Kurca, R. Madar, F. Miconi, A. V. Popov, A. Jayasinghe, Philip Baringer, Sergey Burdin, Matthias Schott, K. Herner, G. W. Wilson, A. Y. Verkheev, E. E. Boos, Oleg Brandt, Dmitri Tsybychev, R. Lopes De Sá, J. Martínez-Ortega, R. Partridge, M. Buehler, B. Tuchming, B. Hoeneisen, Ulrich Heintz, S. Banerjee, S. P. Denisov, H. D. Wahl, D. N. Brown, Guennadi Borissov, J. Warchol, Michael Mulhearn, Aran Garcia-Bellido, Gavin Grant Hesketh, Horst Severini, Heriberto Castilla-Valdez, H. S. Lee, Lee Sawyer, P. Svoisky, D. Hedin, M. Cooke, Frank Filthaut, M. Diesburg, Carlos Avila, J. Joshi, M. P. Sanders, Erik A. Johnson, Anand Kumar Dubey, Richard B. Lipton, K. A. Johns, A. Drutskoy, G. C. Blazey, D. A. Stoyanova, P. Jiang, E. De La Cruz-Burelo, Konstantinos Petridis, Y. L. Liu, R. Yamada, Tim Scanlon, S. Söldner-Rembold, A. Fauré, Nikos Varelas, M. M. Meijer, A. K. Alton, T. Yasuda, C. L. McGivern, Bing Zhou, R. Jesik, Zdenek Hubacek, B. Quinn, A. Pal, M. Strauss, V. Bunichev, Thomas Hebbeker, Carsten Hensel, Scott Snyder, O. Shkola, M. Eads, M. Jaffré, Markus Wobisch, Nazar Stefaniuk, B. S. Acharya, J. Zennamo, Suman Bala Beri, B. Penning, Alexander Kupco, A. S. Ito, I. Katsanos, B. C. K. Casey, N. Parua, D. Vilanova, Randy Ruchti, V. V. Lipaev, J. Lellouch, D. Edmunds, Angelo De Souza Santos, Zhenyu Ye, E. Camacho-Pérez, Reinhard Schwienhorst, M. C. Cousinou, W. M. Van Leeuwen, V. Aushev, V. E. Bazterra, Marc Besancon, Emanuela Barberis, M. Borysova, O. Gogota, R. D. Schamberger, Ji Zhu, Savanna Marie Shaw, M. Vesterinen, V. M. Podstavkov, M. Fortner, A. Chandra, and Ph Gris

Subjects
Quantum chromodynamics, Physics, Luminosity (scattering theory), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Electroweak interaction, Detector calibration, 01 natural sciences, Nuclear physics, Distribution (mathematics), 0103 physical sciences, Transverse momentum, Nuclear Experiment, 010306 general physics, Boson, Bar (unit)
Abstract

We present a study of the normalized transverse momentum distribution of W bosons produced in p (p) over bar collisions, using data corresponding to an integrated luminosity of 4.35 fb(-1) collecte ...

Published
2021
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69. Odderon Exchange from Elastic Scattering Differences between pp and pp[over ¯] Data at 1.96 TeV and from pp Forward Scattering Measurements

Author

V M, Abazov, B, Abbott, B S, Acharya, M, Adams, T, Adams, J P, Agnew, G D, Alexeev, G, Alkhazov, A, Alton, G A, Alves, G, Antchev, A, Askew, P, Aspell, A C S, Assis Jesus, I, Atanassov, S, Atkins, K, Augsten, V, Aushev, Y, Aushev, V, Avati, C, Avila, F, Badaud, J, Baechler, L, Bagby, C, Baldenegro Barrera, B, Baldin, D V, Bandurin, S, Banerjee, E, Barberis, P, Baringer, J, Barreto, J F, Bartlett, U, Bassler, V, Bazterra, A, Bean, M, Begalli, L, Bellantoni, V, Berardi, S B, Beri, G, Bernardi, R, Bernhard, M, Berretti, I, Bertram, M, Besançon, R, Beuselinck, P C, Bhat, S, Bhatia, V, Bhatnagar, G, Blazey, S, Blessing, K, Bloom, A, Boehnlein, D, Boline, E E, Boos, V, Borchsh, G, Borissov, M, Borysova, E, Bossini, U, Bottigli, M, Bozzo, A, Brandt, O, Brandt, M, Brochmann, R, Brock, A, Bross, D, Brown, X B, Bu, M, Buehler, V, Buescher, V, Bunichev, S, Burdin, H, Burkhardt, C P, Buszello, F S, Cafagna, E, Camacho-Pérez, W, Carvalho, B C K, Casey, H, Castilla-Valdez, M G, Catanesi, S, Caughron, S, Chakrabarti, K M, Chan, A, Chandra, E, Chapon, G, Chen, S W, Cho, S, Choi, B, Choudhary, S, Cihangir, D, Claes, J, Clutter, M, Cooke, W E, Cooper, M, Corcoran, F, Couderc, M-C, Cousinou, M, Csanád, T, Csörgő, J, Cuth, D, Cutts, H, da Motta, A, Das, G, Davies, M, Deile, S J, de Jong, E, De La Cruz-Burelo, F, De Leonardis, F, Déliot, R, Demina, D, Denisov, S P, Denisov, C, De Oliveira Martins, S, Desai, C, Deterre, K, DeVaughan, H T, Diehl, M, Diesburg, P F, Ding, A, Dominguez, M, Doubek, A, Drutskoy, D, Druzhkin, A, Dubey, L V, Dudko, A, Duperrin, S, Dutt, M, Eads, D, Edmunds, K, Eggert, J, Ellison, V D, Elvira, Y, Enari, V, Eremin, H, Evans, A, Evdokimov, V N, Evdokimov, A, Fauré, L, Feng, T, Ferbel, F, Ferro, F, Fiedler, A, Fiergolski, F, Filthaut, W, Fisher, H E, Fisk, L, Forthomme, M, Fortner, H, Fox, J, Franc, S, Fuess, P H, Garbincius, F, Garcia, A, Garcia-Bellido, J A, García-González, V, Gavrilov, W, Geng, V, Georgiev, C E, Gerber, Y, Gershtein, S, Giani, G, Ginther, O, Gogota, G, Golovanov, P D, Grannis, S, Greder, H, Greenlee, G, Grenier, Ph, Gris, J-F, Grivaz, A, Grohsjean, S, Grünendahl, M W, Grünewald, L, Grzanka, T, Guillemin, G, Gutierrez, P, Gutierrez, J, Haley, J, Hammerbauer, L, Han, K, Harder, A, Harel, J M, Hauptman, J, Hays, T, Head, T, Hebbeker, D, Hedin, H, Hegab, A P, Heinson, U, Heintz, C, Hensel, I, Heredia-De La Cruz, K, Herner, G, Hesketh, M D, Hildreth, R, Hirosky, T, Hoang, J D, Hobbs, B, Hoeneisen, J, Hogan, M, Hohlfeld, J L, Holzbauer, I, Howley, Z, Hubacek, V, Hynek, I, Iashvili, Y, Ilchenko, R, Illingworth, T, Isidori, A S, Ito, V, Ivanchenko, S, Jabeen, M, Jaffré, M, Janda, A, Jayasinghe, M S, Jeong, R, Jesik, P, Jiang, K, Johns, E, Johnson, M, Johnson, A, Jonckheere, P, Jonsson, J, Joshi, A W, Jung, A, Juste, E, Kajfasz, A, Karev, D, Karmanov, J, Kašpar, I, Katsanos, M, Kaur, B, Kaynak, R, Kehoe, S, Kermiche, N, Khalatyan, A, Khanov, A, Kharchilava, Y N, Kharzheev, I, Kiselevich, J M, Kohli, J, Kopal, A V, Kozelov, J, Kraus, A, Kumar, V, Kundrát, A, Kupco, T, Kurča, V A, Kuzmin, S, Lami, S, Lammers, G, Latino, P, Lebrun, H S, Lee, S W, Lee, W M, Lee, X, Le, J, Lellouch, D, Li, H, Li, L, Li, Q Z, Li, J K, Lim, D, Lincoln, C, Lindsey, R, Linhart, J, Linnemann, V V, Lipaev, R, Lipton, H, Liu, Y, Liu, A, Lobodenko, M, Lokajicek, M V, Lokajíček, R, Lopes de Sa, L, Losurdo, F, Lucas Rodríguez, R, Luna-Garcia, A L, Lyon, A K A, Maciel, M, Macrí, R, Madar, R, Magaña-Villalba, M, Malawski, H B, Malbouisson, S, Malik, V L, Malyshev, J, Mansour, J, Martínez-Ortega, R, McCarthy, C L, McGivern, M M, Meijer, A, Melnitchouk, D, Menezes, P G, Mercadante, M, Merkin, A, Meyer, J, Meyer, F, Miconi, N, Minafra, S, Minutoli, J, Molina, N K, Mondal, M, Mulhearn, L, Mundim, T, Naaranoja, E, Nagy, M, Narain, R, Nayyar, H A, Neal, J P, Negret, F, Nemes, P, Neustroev, H T, Nguyen, H, Niewiadomski, T, Novák, T, Nunnemann, V, Oguri, E, Oliveri, F, Oljemark, J, Orduna, M, Oriunno, N, Osman, K, Österberg, A, Pal, P, Palazzi, N, Parashar, V, Parihar, S K, Park, R, Partridge, N, Parua, R, Pasechnik, V, Passaro, A, Patwa, B, Penning, M, Perfilov, Z, Peroutka, Y, Peters, K, Petridis, G, Petrillo, P, Pétroff, M-A, Pleier, V M, Podstavkov, A V, Popov, W L, Prado da Silva, M, Prewitt, D, Price, J, Procházka, N, Prokopenko, J, Qian, A, Quadt, B, Quinn, M, Quinto, T G, Raben, E, Radermacher, E, Radicioni, M, Rangel, P N, Ratoff, F, Ravotti, I, Razumov, I, Ripp-Baudot, F, Rizatdinova, E, Robutti, R F, Rodrigues, M, Rominsky, A, Ross, C, Royon, P, Rubinov, R, Ruchti, G, Ruggiero, H, Saarikko, G, Sajot, V D, Samoylenko, A, Sánchez-Hernández, M P, Sanders, A, Santoro, A S, Santos, G, Savage, M, Savitskyi, L, Sawyer, T, Scanlon, R D, Schamberger, Y, Scheglov, H, Schellman, M, Schott, C, Schwanenberger, R, Schwienhorst, A, Scribano, J, Sekaric, H, Severini, E, Shabalina, V, Shary, S, Shaw, A A, Shchukin, O, Shkola, V, Simak, J, Siroky, P, Skubic, P, Slattery, J, Smajek, W, Snoeys, G R, Snow, J, Snow, S, Snyder, S, Söldner-Rembold, L, Sonnenschein, K, Soustruznik, J, Stark, N, Stefaniuk, R, Stefanovitch, A, Ster, D A, Stoyanova, M, Strauss, L, Suter, P, Svoisky, I, Szanyi, J, Sziklai, C, Taylor, E, Tcherniaev, M, Titov, V V, Tokmenin, Y-T, Tsai, D, Tsybychev, B, Tuchming, C, Tully, N, Turini, O, Urban, L, Uvarov, S, Uvarov, S, Uzunyan, V, Vacek, R, Van Kooten, W M, van Leeuwen, N, Varelas, E W, Varnes, I A, Vasilyev, O, Vavroch, A Y, Verkheev, L S, Vertogradov, M, Verzocchi, M, Vesterinen, D, Vilanova, P, Vokac, H D, Wahl, C, Wang, M H L S, Wang, J, Warchol, G, Watts, M, Wayne, J, Weichert, J, Welti, L, Welty-Rieger, J, Williams, M R J, Williams, G W, Wilson, M, Wobisch, D R, Wood, T R, Wyatt, Y, Xie, R, Yamada, S, Yang, T, Yasuda, Y A, Yatsunenko, W, Ye, Z, Ye, H, Yin, K, Yip, S W, Youn, J M, Yu, J, Zennamo, T G, Zhao, B, Zhou, J, Zhu, J, Zich, K, Zielinski, M, Zielinski, D, Zieminska, and L, Zivkovic

Abstract

We describe an analysis comparing the pp[over ¯] elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in pp collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections, extrapolated to a center-of-mass energy of sqrt[s]=1.96 TeV, are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the pp cross section. The two data sets disagree at the 3.4σ level and thus provide evidence for the t-channel exchange of a colorless, C-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same C-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic strong interaction scattering amplitude in pp scattering for which the significance is between 3.4σ and 4.6σ. The combined significance is larger than 5σ and is interpreted as the first observation of the exchange of a colorless, C-odd gluonic compound.

Published
2021

70. Search for heavy neutrinos in \(\pi ^{ + } \to \mu ^{ + }\nu \) decay and status of lepton universality test in the PIENU experiment

Author

T. Numao, Douglas Bryman, Chloé Malbrunot, P. Gumplinger, S. Cuen-Rochin, Dave Britton, Ahmed Hussein, A. Sher, D. Protopopescu, J. R. Comfort, L. S. Littenberg, T. Sullivan, Y. Igarashi, R. E. Mischke, Leonid Kurchaninov, Song Chen, S. Ito, S. H. Kettell, D. Vom Bruch, M. Blecher, Alexis A. Aguilar-Arevalo, Luca Doria, D. Vavilov, Masaharu Aoki, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)

Subjects
Physics, Particle physics, Muon, +muon%2B+neutrino%22">pi+ --> muon+ neutrino, pi: decay, neutrino: heavy: search for, Universality (philosophy), Pontecorvo–Maki–Nakagawa–Sakata matrix, kinetic, energy spectrum, Kinetic energy, Pion, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Neutrino, neutrino: mixing, Order of magnitude, Particle Physics - Experiment, Lepton, experimental results, lepton: universality
Abstract

International audience; In the present work of the PIENU experiment, heavy neutrinos were sought in pion decays \(\pi ^{ + } \to \mu ^{ + }\nu \). No evidence for extra peak was found in the muon kinetic energy spectrum and 90% confidence level upper limits were set on the neutrino mixing matrix \(|U_{\mu i}|^{2}\) in the mass range of 15.7 to 33.8 MeV/c^2, improving an order of magnitude over previous experiments. Current status of lepton universality test is also reported.

Published
2021
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71. Hydrogen Absorption Method Using HfOx in Crystalline In-Ga-Zn Oxide FETs for NVM Applications

Author

Shinya Sasagawa, Naoki Okuno, Shunpei Yamazaki, H. Komagata, Y. Komatsu, Hitoshi Kunitake, T. Ono, Y. Yamane, T. Aoki, S. Ito, Y. Jimbo, and Yuichi Yanagisawa

Subjects
Materials science, Hydrogen, business.industry, Oxide, chemistry.chemical_element, Threshold voltage, Non-volatile memory, chemistry.chemical_compound, chemistry, Logic gate, Optoelectronics, Field-effect transistor, Hydrogen absorption, business, Layer (electronics)
Abstract

We fabricated and evaluated an oxide semiconductor field effect transistor (OSFET) with a channel of c-axis aligned crystalline In-Ga-Zn oxide (CAAC-IGZO) in order to examine the availability of the OSFET in nonvolatile memories (NVM). A featured extremely low leakage current of the OSFET largely depends on the threshold voltage, and thus controlling the threshold is a key issue. In particular, reducing the hydrogen concentration in and around the CAAC-IGZO layer as much as possible is one of the most important factors leading to threshold controllability and stability improvement in the OSFET. Accordingly, we employed a structure in which the whole OSFET is sealed with a hydrogen barrier film (SiNx) to prevent hydrogen entry from the outside and provided a modified HfOx film that we found serves as a hydrogen absorption layer inside the encapsulation structure. The HfOx film having a high hydrogen absorption capability inside the encapsulation structure resulted in a significant improvement in OSFET reliability. Specifically, the prototype OSFET with a gate length of 43.9 nm had a suppressed threshold variation for 500 hours in the positive gate-bias temperature (+GBT) stress test (150°C, V gs = 3.63 V, V ds = V bgs = 0 V). This process enables the control of the hydrogen concentration in the CAAC-IGZO layer and increases the expectation for OSFET mass production.

Published
2020
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72. Classification of HFrEF based on echocardiography using machine learning to predict future HFrecEF events

Author

S. Ito, Hiroyuki Yoshitomi, Kazuaki Tanabe, Takahiro Sakamoto, and Akihiro Endo

Subjects
medicine.medical_specialty, Ejection fraction, business.industry, Heart failure, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, medicine.disease, business
Abstract

Background In recent years, there have been sporadic reports of heart failure with recovered ejection fraction (HFrecEF), wherein the left ventricular EF (LVEF) has been improved by considering temporal changes in the LVEF. Although patients with HFrecEF are known to have a better prognosis than other groups, the type of heart failure associated with reduced EF (HFrEF) that subsequently transitions to HFrecEF is yet to be determined. Purpose In this study, we examined whether it is possible to predict future HFrecEF events by stratifying the HFrEF using machine learning based on previously recorded echocardiographic indices. Methods For 162 patients, with HFrEF and a history of hospitalization owing to heart failure, who underwent echocardiography in a stable hemodynamic state, stratification was performed via machine learning. Regarding temporal changes in the LVEF, 73 patients who underwent another echocardiography under stable conditions were investigated (52 with continued HFrEF and 21 with HFrecEF, with a median follow up of 397 days). HFrEF was defined as a condition for patients with an LVEF of less than 50%, and HFrecEF was defined as a condition for patients who initially had an LVEF of less than 50% but later improved. Patients with severe valvular disease, acute myocardial infarction, acute myocarditis, acute pulmonary embolism, post-cardiac surgery, and pericardial disease were excluded from this group. The random forest method was used as a classification method for machine learning. Results When 162 patients with HFrEF were stratified using machine learning, 63 were classified into Cluster 1 and 99 into Cluster 2. Cluster 1 patients showed a significantly higher tendency to transition to HFrecEF than Cluster 2 patients (p=0.001). The Gini coefficient was calculated to identify echocardiographic indices that are important for the purpose of stratification. As a result, LVEF, left ventricular endo-diastolic volume (LVEDV), the thickness of interventricular septum (IVSth), E/A ratio, and the maximum diameter of the inferior vena cava were found to be particularly important. Compared to Cluster 2 patients, Cluster 1 patients exhibited a significantly higher LVEF (41.5±5.9% vs 27.0±7.6%, p Conclusion Stratifying HFrEF via machine learning based on echocardiographic indices can help predict temporal changes in the LVEF and deduce the echocardiographic indices useful for improving LVEF. Funding Acknowledgement Type of funding source: None

Published
2020
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73. Development of a Method for Determining the Search Window for Solar Flare Neutrinos

Author

Satoshi Masuda, Yoshitaka Itow, K. Okamoto, Toshio Terasawa, M. Miyake, Yuuki Nakano, Masayuki Nakahata, and S. Ito

Subjects
010504 meteorology & atmospheric sciences, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Neutron, Geostationary Operational Environmental Satellite, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Line (formation), High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Solar flare, Astronomy and Astrophysics, Light curve, Particle acceleration, Astrophysics - Solar and Stellar Astrophysics, Neutrino detector, Space and Planetary Science, Physics::Space Physics, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Neutrinos generated during solar flares remain elusive. However, after $50$ years of discussion and search, the potential knowledge unleashed by their discovery keeps the search crucial. Neutrinos associated with solar flares provide information on otherwise poorly known particle acceleration mechanisms during solar flare. For neutrino detectors, the separation between atmospheric neutrinos and solar flare neutrinos is technically encumbered by an energy band overlap. To improve differentiation from background neutrinos, we developed a method to determine the temporal search window for neutrino production during solar flares. Our method is based on data recorded by solar satellites, such as Geostationary Operational Environmental Satellite (GOES), Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI), and GEOTAIL. In this study, we selected 23 solar flares above the X5.0 class that occurred between 1996 and 2018. We analyzed the light curves of soft X-rays, hard X-rays, $\gamma$-rays, line $\gamma$-rays from neutron capture as well as the derivative of soft X-rays. The average search windows are determined as follows: $4,178$ s for soft X-ray, $700$ s for derivative of soft X-ray, $944$ s for hard X-ray ($100$-$800$ keV), $1,586$ s for line $\gamma$-ray from neutron captures, and $776$ s for hard X-ray (above $50$ keV). This method allows neutrino detectors to improve their sensitivity to solar flare neutrinos., Comment: 29 pages. Accepted for Solar Physics

Published
2020
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74. Microcatheter Originating Debris during Neuroendovascular Procedures: Mechanism of Dislodgement and Its Prevention

Author

Yuichi Murayama, Kostadin Karagiozov, S. Sato, S. Ito, and Issei Kan

Subjects
medicine.medical_specialty, Catheters, Interventional, business.industry, Debris, 030218 nuclear medicine & medical imaging, Surgery, 03 medical and health sciences, Catheter, 0302 clinical medicine, Port (medical), Intracranial Embolism, Neuroendoscopy, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

SUMMARY: Embolic material dislodgement from microcatheters can potentially induce subclinical brain damage as evidenced by a delayed enhanced or other type of lesions. Some of the most frequently used microcatheters were investigated in vitro in different setups and combinations with different port insertions and rotating hemostatic valves. It was found that side port application increases injury to the catheter surface and debris dislodgement by conflicting with internal ledges in rotating hemostatic valves. This initial observation suggests the need for measures to remove the produced debris during such procedures.

Published
2020

75. The Hyper-Kamiokande Experiment -- Snowmass LOI

Author

Hyper-Kamiokande Collaboration, K. Abe, P. Adrich, H. Aihara, R. Akutsu, I. Alekseev, A. Ali, F. Ameli, L. H. V. Anthony, A. Araya, Y. Asaoka, V. Aushev, I. Bandac, M. Barbi, G. Barr, M. Batkiewicz-Kwasniak, M. Bellato, V. Berardi, L. Bernard, E. Bernardini, L. Berns, S. Bhadra, J. Bian, A. Blanchet, A. Blondel, A. Boiano, S. Bolognesi, L. Bonavera, S. Borjabad, T. Boschi, D. Bose, S . B. Boyd, C. Bozza, A. Bravar, C. Bronner, A. Bubak, A. Buchowicz, M. Buizza Avanzini, F. S. Cafagna, N. F. Calabria, J. M. Calvo-Mozota, S. Cao, M. G. Catanesi, S. Chakraborty, J. H. Choi, S. Choubey, M. Cicerchia, J. Coleman, G. Collazuol, S. Cuen-Rochin, M. Danilov, E. De la Fuente, P. de Perio, G. De Rosa, T. Dealtry, C. J. Densham, A. Dergacheva, N. Deshmukh, M. M. Devi, F. Di Lodovico, P. Di Meo, I. Di Palma, T. A. Doyle, E. Drakopoulou, O. Drapier, J. Dumarchez, L. Eklund, S. El Hedri, J. Ellis, S. Emery, A. Esmaili, S. Fedotov, J. Feng, E. Fernández-Martinez, P. Ferrario, B. Ferrazzi, A. Finch, C. Finley, G. Fiorillo, M. Fitton, M. Friend, Y. Fujii, Y. Fukuda, G. Galinski, J. Gao, C. Garde, A. Garfagnini, S. Garode, L. Gialanella, C. Giganti, J. J. Gomez-Cadenas, M. Gonin, J. González-Nuevo, A. Gorin, R. Gornea, F. Gramegna, M. Grassi, G. Grella, M. Guigue, D. R. Hadley, M. Harada, M. Hartz, S. Hassani, N. C. Hastings, Y. Hayato, K. Hiraide, K. Hoshina, K. Hultqvist, F. Iacob, A. K. Ichikawa, W. Idrissi Ibnsalih, M. Ikeda, M. Inomoto, A. Ioannisian, T. Ishida, K. Ishidoshiro, H. Ishino, M. Ishitsuka, H. Ito, S. Ito, Y. Itow, K. Iwamoto, N. Izumi, S. Izumiyama, M. Jakkapu, B. Jamieson, J. S. Jang, H. S. Jo, P. Jonsson, K. K. Joo, T. Kajita, H. Kakuno, J. Kameda, Y. Kano, D. Karlen, Y. Kataoka, A. Kato, T. Katori, N. Kazarian, M. Khabibullin, A. Khotjantsev, T. Kikawa, J. Y. Kim, S. B. Kim, S. King, T. Kinoshita, J. Kisiel, A. Klekotko, T. Kobayashi, L. Koerich, N. Kolev, A. Konaka, L. L. Kormos, Y. Koshio, Y. Kotsar, K. A. Kouzakov, K. L. Kowalik, L. Kravchuk, A. P. Kryukov, Y. Kudenko, T. Kumita, R. Kurjata, T. Kutter, M. Kuze, K. Kwak, M. La Commara, L. Labarga, J. Lagoda, M. Lamoureux, M. Laveder, L. Lavitola, J. Lee, R. Leitner, V. Lezaun, I. T. Lim, T. Lindner, R. P. Litchfield, K. R. Long, A. Longhin, P. Loverre, X. Lu, L. Ludovici, Y. Maekawa, L. Magaletti, K. Magar, Y. Makida, M. Malek, M. Malinský, T. Marchi, C. Mariani, A. Marinelli, K. Martens, Ll. Marti, J. F. Martin, D. Martin, J. Marzec, T. Matsubara, R. Matsumoto, N. McCauley, A. Medhi, P. Mehta, L. Mellet, H. Menjo, M. Mezzetto, J. Migenda, P. Migliozzi, S. Miki, A. Minamino, S. Mine, O. Mineev, A. Mitra, M. Miura, R. Moharana, C. M. Mollo, T. Mondal, M. Mongelli, F. Monrabal, D. H. Moon, C. S. Moon, S. Moriyama, T. Mueller, Y. Nagao, T. Nakadaira, K. Nakagiri, M. Nakahata, S. Nakai, Y. Nakajima, K. Nakamura, KI. Nakamura, H. Nakamura, Y. Nakano, T. Nakaya, S. Nakayama, K. Nakayoshi, L. Nascimento Machado, C. E. R. Naseby, B. Navarro-Garcia, M. Needham, K. Niewczas, Y. Nishimura, F. Nova, J. C. Nugent, H. Nunokawa, W. Obrebski, J. P. Ochoa-Ricoux, E. O'Connor, N. Ogawa, T. Ogitsu, K. Okamoto, H. M. O'Keeffe, K. Okumura, Y. Onishchuk, F. Orozco-Luna, A. Oshlianskyi, N. Ospina, M. Ostrowski, E. O'Sullivan, Y. Oyama, H. Ozaki, M. Y. Pac, P. Paganini, V. Palladino, M. Pari, J. Pasternak, C. Pastore, G. Pastuszak, D. A. Patel, M. Pavin, D. Payne, C. Peña-Garay, C. Pidcott, S. Playfer, B. W. Pointon, A. Popov, B. Popov, K. Porwit, M. Posiadala-Zezula, G. Pronost, N. W. Prouse, B. Quilain, A. A. Quiroga, E. Radicioni, B. Radics, P. J. Rajda, M. Rescigno, G. Ricciardi, B. Richards, E. Rondio, B. Roskovec, S. Roth, C. Rott, A. Rubbia, A. C. Ruggeri, S. Russo, A. Rychter, D. Ryu, K. Sakashita, S. Samani, F. Sánchez, M. L. Sánchez, S. Sano, J. D. Santos, G. Santucci, P. Sarmah, K. Sato, M. Scott, Y. Seiya, T. Sekiguchi, H. Sekiya, J. W. Seo, D. Sgalaberna, A. Shaykina, I. Shimizu, C. D. Shin, M. Shinoki, M. Shiozawa, N. Skrobova, K. Skwarczynski, M. B. Smy, J. Sobczyk, H. W. Sobel, F. J. P. Soler, Y. Sonoda, R. Spina, B. Spisso, P. Spradlin, K. L. Stankevich, L. Stawarz, S. M. Stellacci, A. I. Studenikin, S. L. Suárez Gómez, T. Suganuma, S. Suvorov, Y. Suwa, A. T. Suzuki, S. Suzuki, Y. Suzuki, D. Svirida, M. Taani, M. Tada, A. Takeda, Y. Takemoto, A. Takenaka, A. Taketa, Y. Takeuchi, H. Tanaka, H. I. Tanaka, M. Tanaka, T. Tashiro, M. Thiesse, L. F. Thompson, A. K. Tomatani-Sánchez, G. Tortone, K. M. Tsui, T. Tsukamoto, M. Tzanov, Y. Uchida, M. R. Vagins, S. Valder, V. Valentino, G. Vasseur, A. Vijayvargi, W. G. S. Vinning, D. Vivolo, R. B. Vogelaar, M. M. Vyalkov, T. Wachala, J. Walker, D. Wark, M. O. Wascko, R. A. Wendell, J. R. Wilson, S. Wronka, J. Xia, Y. Yamaguchi, K. Yamamoto, T. Yano, N. Yershov, M. Yokoyama, J. Yoo, I. Yu, T. Zakrzewski, B. Zaldivar, J. Zalipska, K. Zaremba, G. Zarnecki, M. Ziembicki, K. Zietara, M. Zito, S. Zsoldos, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Hyper-Kamiokande, HEP, INSPIRE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Collaboration, Hyper-Kamiokande, Abe, K., Adrich, P., Aihara, H., Akutsu, R., Alekseev, I., Ali, A., Ameli, F., Anthony, L. H. V., Araya, A., Asaoka, Y., Aushev, V., Bandac, I., Barbi, M., Barr, G., Batkiewicz-Kwasniak, M., Bellato, M., Berardi, V., Bernard, L., Bernardini, E., Berns, L., Bhadra, S., Bian, J., Blanchet, A., Blondel, A., Boiano, A., Bolognesi, S., Bonavera, L., Borjabad, S., Boschi, T., Bose, D., Boyd, S . B., Bozza, C., Bravar, A., Bronner, C., Bubak, A., Buchowicz, A., Buizza Avanzini, M., Cafagna, F. S., Calabria, N. F., Calvo-Mozota, J. M., Cao, S., Catanesi, M. G., Chakraborty, S., Choi, J. H., Choubey, S., Cicerchia, M., Coleman, J., Collazuol, G., Cuen-Rochin, S., Danilov, M., De la Fuente, E., de Perio, P., De Rosa, G., Dealtry, T., Densham, C. J., Dergacheva, A., Deshmukh, N., Devi, M. M., Di Lodovico, F., Di Meo, P., Di Palma, I., Doyle, T. A., Drakopoulou, E., Drapier, O., Dumarchez, J., Eklund, L., El Hedri, S., Ellis, J., Emery, S., Esmaili, A., Fedotov, S., Feng, J., Fernández-Martinez, E., Ferrario, P., Ferrazzi, B., Finch, A., Finley, C., Fiorillo, G., Fitton, M., Friend, M., Fujii, Y., Fukuda, Y., Galinski, G., Gao, J., Garde, C., Garfagnini, A., Garode, S., Gialanella, L., Giganti, C., Gomez-Cadenas, J. J., Gonin, M., González-Nuevo, J., Gorin, A., Gornea, R., Gramegna, F., Grassi, M., Grella, G., Guigue, M., Hadley, D. R., Harada, M., Hartz, M., Hassani, S., Hastings, N. C., Hayato, Y., Hiraide, K., Hoshina, K., Hultqvist, K., Iacob, F., Ichikawa, A. K., Idrissi Ibnsalih, W., Ikeda, M., Inomoto, M., Ioannisian, A., Ishida, T., Ishidoshiro, K., Ishino, H., Ishitsuka, M., Ito, H., Ito, S., Itow, Y., Iwamoto, K., Izumi, N., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, J. S., Jo, H. S., Jonsson, P., Joo, K. K., Kajita, T., Kakuno, H., Kameda, J., Kano, Y., Karlen, D., Kataoka, Y., Kato, A., Katori, T., Kazarian, N., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, J. Y., Kim, S. B., King, S., Kinoshita, T., Kisiel, J., Klekotko, A., Kobayashi, T., Koerich, L., Kolev, N., Konaka, A., Kormos, L. L., Koshio, Y., Kotsar, Y., Kouzakov, K. A., Kowalik, K. L., Kravchuk, L., Kryukov, A. P., Kudenko, Y., Kumita, T., Kurjata, R., Kutter, T., Kuze, M., Kwak, K., La Commara, M., Labarga, L., Lagoda, J., Lamoureux, M., Laveder, M., Lavitola, L., Lee, J., Leitner, R., Lezaun, V., Lim, I. T., Lindner, T., Litchfield, R. P., Long, K. R., Longhin, A., Loverre, P., Lu, X., Ludovici, L., Maekawa, Y., Magaletti, L., Magar, K., Makida, Y., Malek, M., Malinský, M., Marchi, T., Mariani, C., Marinelli, A., Martens, K., Marti, Ll., Martin, J. F., Martin, D., Marzec, J., Matsubara, T., Matsumoto, R., Mccauley, N., Medhi, A., Mehta, P., Mellet, L., Menjo, H., Mezzetto, M., Migenda, J., Migliozzi, P., Miki, S., Minamino, A., Mine, S., Mineev, O., Mitra, A., Miura, M., Moharana, R., Mollo, C. M., Mondal, T., Mongelli, M., Monrabal, F., Moon, D. H., Moon, C. S., Moriyama, S., Mueller, T., Nagao, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakai, S., Nakajima, Y., Nakamura, K., Nakamura, Ki., Nakamura, H., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Nascimento Machado, L., Naseby, C. E. R., Navarro-Garcia, B., Needham, M., Niewczas, K., Nishimura, Y., Nova, F., Nugent, J. C., Nunokawa, H., Obrebski, W., Ochoa-Ricoux, J. P., O'Connor, E., Ogawa, N., Ogitsu, T., Okamoto, K., O'Keeffe, H. M., Okumura, K., Onishchuk, Y., Orozco-Luna, F., Oshlianskyi, A., Ospina, N., Ostrowski, M., O'Sullivan, E., Oyama, Y., Ozaki, H., Pac, M. Y., Paganini, P., Palladino, V., Pari, M., Pasternak, J., Pastore, C., Pastuszak, G., Patel, D. A., Pavin, M., Payne, D., Peña-Garay, C., Pidcott, C., Playfer, S., Pointon, B. W., Popov, A., Popov, B., Porwit, K., Posiadala-Zezula, M., Pronost, G., Prouse, N. W., Quilain, B., Quiroga, A. A., Radicioni, E., Radics, B., Rajda, P. J., Rescigno, M., Ricciardi, G., Richards, B., Rondio, E., Roskovec, B., Roth, S., Rott, C., Rubbia, A., Ruggeri, A. C., Russo, S., Rychter, A., Ryu, D., Sakashita, K., Samani, S., Sánchez, F., Sánchez, M. L., Sano, S., Santos, J. D., Santucci, G., Sarmah, P., Sato, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaykina, A., Shimizu, I., Shin, C. D., Shinoki, M., Shiozawa, M., Skrobova, N., Skwarczynski, K., Smy, M. B., Sobczyk, J., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Spina, R., Spisso, B., Spradlin, P., Stankevich, K. L., Stawarz, L., Stellacci, S. M., Studenikin, A. I., Suárez Gómez, S. L., Suganuma, T., Suvorov, S., Suwa, Y., Suzuki, A. T., Suzuki, S., Suzuki, Y., Svirida, D., Taani, M., Tada, M., Takeda, A., Takemoto, Y., Takenaka, A., Taketa, A., Takeuchi, Y., Tanaka, H., Tanaka, H. I., Tanaka, M., Tashiro, T., Thiesse, M., Thompson, L. F., Tomatani-Sánchez, A. K., Tortone, G., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Valder, S., Valentino, V., Vasseur, G., Vijayvargi, A., Vinning, W. G. S., Vivolo, D., Vogelaar, R. B., Vyalkov, M. M., Wachala, T., Walker, J., Wark, D., Wascko, M. O., Wendell, R. A., Wilson, J. R., Wronka, S., Xia, J., Yamaguchi, Y., Yamamoto, K., Yano, T., Yershov, N., Yokoyama, M., Yoo, J., Yu, I., Zakrzewski, T., Zaldivar, B., Zalipska, J., Zaremba, K., Zarnecki, G., Ziembicki, M., Zietara, K., Zito, M., and Zsoldos, S.

Subjects
nucleon: decay, Physics - Instrumentation and Detectors, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Cherenkov counter: water, Physics::Instrumentation and Detectors, J-PARC Lab, High Energy Physics::Phenomenology, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), KAMIOKANDE, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], upgrade, High Energy Physics::Experiment, Physics - Instrumentation and Detector, neutrino: oscillation, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], activity report
Abstract

Hyper-Kamiokande is the next generation underground water Cherenkov detector that builds on the highly successful Super-Kamiokande experiment. The detector which has an 8.4~times larger effective volume than its predecessor will be located along the T2K neutrino beamline and utilize an upgraded J-PARC beam with 2.6~times beam power. Hyper-K's low energy threshold combined with the very large fiducial volume make the detector unique, that is expected to acquire an unprecedented exposure of 3.8~Mton$\cdot$year over a period of 20~years of operation. Hyper-Kamiokande combines an extremely diverse science program including nucleon decays, long-baseline neutrino oscillations, atmospheric neutrinos, and neutrinos from astrophysical origins. The scientific scope of this program is highly complementary to liquid-argon detectors for example in sensitivity to nucleon decay channels or supernova detection modes. Hyper-Kamiokande construction has started in early 2020 and the experiment is expected to start operations in 2027. The Hyper-Kamiokande collaboration is presently being formed amongst groups from 19 countries including the United States, whose community has a long history of making significant contributions to the neutrino physics program in Japan. US physicists have played leading roles in the Kamiokande, Super-Kamiokande, EGADS, K2K, and T2K programs., 6 pages, prepared as Snowmass2021 LOI

Published
2020

76. Establishment of nocturnal bladder control and behavioral sexual dimorphism in children

Author

Takahiko Mitsui, S. Ito, Masaaki Nakamura, Nobuo Shinohara, K. Cho, S Murai, Katsuya Nonomura, Atsuko Araki, Y. Nishimura, Kimihiko Moriya, Masafumi Kon, Chihiro Miyashita, Reiko Kishi, and Takeya Kitta

Subjects
Sexual dimorphism, business.industry, Urology, Bladder control, Medicine, Physiology, Nocturnal, business, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Published
2020

78. Lack of association between a disease-susceptible single-nucleotide polymorphism, rs2230926 of

Author

H, Matsuoka, D, Kabata, A, Taura, T, Matsui, K, Takahi, F, Hirano, M, Katayama, A, Okamoto, Y, Suenaga, E, Suematsu, S, Yoshizawa, K, Ohmura, S, Ito, H, Takaoka, E, Oguro, K, Kuzuya, Y, Okita, C, Udagawa, M, Yoshimura, S, Teshigawara, Y, Harada, K, Isoda, Y, Yoshida, S, Ohshima, S, Tohma, and Y, Saeki

Subjects
Adult, Male, Adalimumab, Antibodies, Monoclonal, Middle Aged, Prognosis, Polymorphism, Single Nucleotide, Infliximab, Etanercept, Arthritis, Rheumatoid, Asian People, Japan, Humans, Female, Tumor Necrosis Factor Inhibitors, Treatment Failure, Tumor Necrosis Factor alpha-Induced Protein 3, Aged
Published
2020

79. ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway

Author

Fumika Kitayoshi, Takeshi K. Matsui, Mari Nakanishi, Masaya Matsubayashi, Akihisa Takahashi, Shinko Kobashigawa, Atsuhisa Kajihara, Yoshihiko M. Sakaguchi, Masatoshi Hasegawa, Tadaaki Kirita, Yosuke Nakagawa, Eiichiro Mori, Genro Kashino, Sotaro Kikuchi, Kazuma Sugie, Shigehiro Tamaki, Hitoki Nanaura, and Soichiro S. Ito

Subjects
Blot, Non-homologous end joining, chemistry.chemical_compound, biology, Chemistry, DNA repair, Kinase, biology.protein, Phosphorylation, Homologous recombination, Thymidylate synthase, DNA, Cell biology
Abstract

The anticancer agent, 5-fluorouracil (5-FU), is typically applied in the treatment of various types of cancers because of its properties. Thought to be an inhibitor of the enzyme thymidylate synthase which plays a role in nucleotide synthesis, 5-FU has been found to induce single- and double-strand DNA breaks. The activation of ATR occurs as a reaction to UV- and chemotherapeutic drug-induced replication stress. In this study, we examined the effect of ATR inhibition on 5-FU sensitivity. Using western blotting, we found that 5-FU treatment led to the phosphorylation of ATR. Surviving fractions were remarkably decreased in 5-FU with ATR inhibitor (ATRi) compared to 5-FU with other major DNA repair kinases inhibitors. ATR inhibition enhanced induction of DNA double-strand breaks and apoptosis in 5-FU-treated cells. Using gene expression analysis, we found that 5-FU could induce the activation of intra-S checkpoint. Surprisingly,BRCA2-deficient cells were sensitive to 5-FU in the presence of ATRi. In addition, ATR inhibition enhanced the efficacy of 5-FU treatment, independent of non-homologous end-joining and homologous recombination repair pathways. Findings from the present study suggest ATR as a potential therapeutic target for 5-FU chemotherapy.

Published
2020
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80. Anomalous Hall effect at the spontaneously electron-doped polar surface of PdCoO2 ultrathin films

Author

Kohei Fujiwara, K. Horiba, Takashi Takahashi, Atsushi Tsukazaki, T. J. Sato, M. Kitamura, Tsutomu Nojima, S. Ito, T. Harada, Hiroshi Kumigashira, and Katsuaki Sugawara

Subjects
Surface (mathematics), Materials science, Condensed matter physics, Electron, Electron doped, Metal, Condensed Matter::Materials Science, Ferromagnetism, Hall effect, Condensed Matter::Superconductivity, visual_art, visual_art.visual_art_medium, Polar, Condensed Matter::Strongly Correlated Electrons
Abstract

The authors probe a ferromagnetic state emerging on an atomic surface of a nonmagnetic layered metal PdCoO2. Measurements of PdCoO2 ultrathin films reveal that spin-polarized Pd-derived electrons are flowing at the surface under the influence of triangular lattices of magnetic Co ions.

Published
2020
Full Text
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81. Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen

Author

Y, Ikeuchi-Takahashi, S, Ito, A, Itokawa, M, Ota, Y, Onuki, S, Hidaka, and H, Onishi

Subjects
Excipients, Drug Liberation, Acrylates, Hardness, Polymers, Taste, Tensile Strength, Administration, Oral, Povidone, Hydrogen-Ion Concentration, Acetaminophen, Tablets
Abstract

In the present work, taste masked particles of acetaminophen (AAP), a highly soluble bitter tasting drug, were developed and ODT containing the taste masked particles were prepared. Taste masked particles of AAP were prepared using different amounts of tetraglycerol polyricinoleate (TGPR) and Eudragit ®E100. Although the drug content ratio and drug recovery decreased with increasing TGPR, drug release from AAP-CR100 particles containing a large amount of TGPR was mostly suppressed for 2 min. Hence, AAP-CR100 was incorporated into ODT as taste masked particles for AAP. Three major disintegrants were used for ODT, and it was confirmed that the tensile strength of all formulations showed applicable hardness for handling. The AAP-CR100-CP(40) formulation containing crospovidone showed the shortest disintegration time and the drug release from AAP-CR100-CP(40) into pH 6.8 test solution was suppressed compared with commercial AAP tablets. Because the drug release from AAP-CR100-CP(40) into the pH 1.2 test solution was rapid, it was suggested that drug release from AAP-CR100-CP(40) is suppressed in the oral cavity, and the drug is released promptly in the stomach. Thus AAP-CR100-CP(40) may be useful as an ODT in which the dissolution of AAP in the oral cavity is suppressed.

Published
2020

82. A57 VALPROATE INDUCED DRESS SYNDROME CAUSING MIXED LIVER INJURY

Author

J Hulst, R Verstegen, V Ng, S Ito, and R Schneider

Subjects
Liver injury, medicine.medical_specialty, Valproic Acid, Poster of Distinction, business.industry, Jaundice, medicine.disease, Gastroenterology, Levocarnitine, Epilepsy, Cholestasis, Prednisone, Internal medicine, medicine, Levetiracetam, medicine.symptom, business, medicine.drug
Abstract

Background Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome occurs with 1 in every 1,000 to 10,000 drug exposures and has a mortality rate of up to 10%. It is one mechanism by which medications can induce liver injury with elevated liver enzymes seen in the majority of cases. In children, aromatic anticonvulsants are the drugs most commonly associated with DRESS syndrome. Valproate, a non-aromatic anti-epileptic, is not known to have a heightened risk of hypersensitivity syndromes and is often the anti-epileptic of choice in patients who develop hypersensitivity syndromes from other anti-epileptics. Valproate hepatotoxicity is normally caused by its inhibition of fatty acid transport and mitochondrial β-oxidation; vanishing bile duct syndrome is also reported. Aims We present a case, to the best of our knowledge the first in paediatrics, in which valproate causes DRESS syndrome and a secondary, predominantly cholestatic, liver injury. Methods Literature review and case report. Results A previously healthy 14-year-old girl was diagnosed with new-onset seizures and started on valproate. Three weeks later, she developed a pruritic exanthem. Despite discontinuing her valproate, the rash persisted and she developed fever and jaundice. She was admitted to the ICU at the Hospital for Sick Children with a diagnosis of DRESS syndrome (RegiSCAR DRESS score 7) for treatment with IV steroids. At admission, she had a skin eruption, fever, leukocytosis (22.86 x109/L), eosinophilia (1.03x109/L), atypical lymphocytes (1.62 x109/L), lymphadenopathy, and internal organ involvement (BiliC 138, GGT 501, INR 1.3, ALT 543, AST 370, Crt 109). Of note, her EBV PCR was positive. By discharge, her rash improved and kidney function normalized. Her cholestasis persisted, despite improvement in her transaminases and eosinophilia (BiliC 163, INR 1.0, GGT 338, ALT 506, AST 220, Eos 0.98x109/L). She was discharged home on an oral steroid wean, ursodeoxycholic acid, levocarnitine, and levetiracetam. Upon reaching a daily dose of 20mg of prednisone, her rash and pruritus worsened, she had lost 7kg, and she was readmitted for IV steroids. Her rash improved within 4 days and she was discharged on a slower steroid taper, with the addition of cholestyramine and insulin for steroid induced diabetes. At present (2 ½ months after diagnosis), she continues her oral steroids and has persistent liver injury and pruritus. Conclusions We report the first paediatric case of valproate induced DRESS syndrome causing a significant cholestatic presentation with otherwise preserved liver synthetic function. The prolonged cholestasis and pruritus may be a result of the natural course of DRESS syndrome, EBV reactivation/infection, or polypharmacy. Early recognition of DRESS syndrome as a mechanism of valproate induced liver injury in children is essential for earlier diagnosis and initiation of targeted therapy. Funding Agencies None

Published
2020

85. Additional file 1 of Current status of integrating oncology and palliative care in Japan: a nationwide survey

Author

Y. Uneno, K. Sato, T. Morita, M. Nishimura, S. Ito, M. Mori, C. Shimizu, Y. Horie, M. Hirakawa, T. Nakajima, S. Tsuneto, and M. Muto

Subjects
genetic structures, sense organs, behavioral disciplines and activities, psychological phenomena and processes
Abstract

Additional file 1: TableS1. Perception of the integration of oncology and palliative care programs in Japan

Published
2020
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86. P1409 Sizing of mitral annuloplasty rings using three-dimensional transoesophageal echocardiography

Author

K Yoshitani, Y Ohnishi, T Fujii, S Ito, and A Shimokawa

Subjects
medicine.medical_specialty, Mitral valve repair, Cardiac cycle, business.industry, medicine.medical_treatment, Surgical mortality, Diastole, General Medicine, Transoesophageal echocardiography, medicine.anatomical_structure, Mitral valve, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Systole, Cardiology and Cardiovascular Medicine, business, Mitral Annuloplasty
Abstract

Funding Acknowledgements Department funding Background Mitral valve repair is preferred to valve replacement in cases of degenerative mitral regurgitation (MR) due to the lower risk of valve-related complications and operative mortality. In mitral valve repair, annuloplasty is associated with better clinical outcomes. Sizing of the annuloplasty ring with a ring sizer, which should be performed in the end-systolic phase, is performed in diastole during hyperkalaemia cardioplegic arrest. Three-dimensional transoesophageal echocardiography (3D-TEE) allows measurement of the mitral valve while the heart is beating, which is beneficial since the mitral valve size changes throughout the cardiac cycle. Purpose To investigate whether 3D-TEE measurements of the mitral valve are effective for preventing recurrent mitral regurgitation (MR) in patients who undergo mitral valve repair for degenerative MR. Methods This study retrospectively reviewed 139 patients who underwent mitral annuloplasty for degenerative MR. After 47 patients were excluded, 92 patients were analysed. The inter-commissural (IC) distance and anterior leaflet height of the A2 segment of the mitral valve were measured by 3D-TEE at the end-systolic phase. The annuloplasty ring size and type were selected by surgeons using specific ring sizers. We investigated the association of the IC distance with the size of implanted annulus ring and differences between the size of implanted annulus ring and the IC distance. We also compared the IC distance, the A2 height, and the ratio of A2 height to IC distance between patients with and without recurrent mild-to-moderate MR for 36 months. Results There was a significant correlation between the size of the mitral annuloplasty ring and the IC distance (R²=0.7023, p Conclusions There was a significant correlation between the size of the mitral annuloplasty ring and the IC distance. Our results demonstrated a higher ratio of A2 height to IC distance in patients with recurrent MR. Abstract P1409 Figure1

Published
2020
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87. P1531 Changes in mitral annular dynamics with three different types of annuloplasty devices: measurement using three-dimensional transoesophageal echocardiography

Author

Y Onishi, M Yahagi, K Yoshitani, and S Ito

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, Transoesophageal echocardiography, business
Abstract

OnBehalf National Cerebral and Cardiovascular Center, Japan Background/Purpose Mitral annuloplasty plays a crucial role during mitral valve (MV) repair. The dynamics of the mitral annulus (MA) may be variously affected by the annuloplasty device. Therefore, we investigated the differences in MA dynamics when using a semi-rigid ring, semi-rigid band, and flexible ring. Methods We retrospectively reviewed 61 patients with mitral regurgitation who underwent MV repair, which included annuloplasty. Semi-rigid rings were used in 33 patients, flexible bands in 21, and semi-rigid bands in seven. Three-dimensional transoesophageal echocardiography (3D-TEE) images of the MV were recorded before and after annuloplasty. The 3D-TEE image datasets were analysed using semi-automated analysis software. We measured anterolateral–posteromedial (AL–PM) and anteroposterior (AP) diameter and height of the MV. The sphericity index (AP diameter divided by AL-PM diameter) and annular height to commissural width ratio (AHCWR) were calculated as the circular and saddle-shaped geometries, respectively. The differences in these values between end diastole (ED) and end systole (ES) were compared by t-test before and after mitral annuloplasty to analyse the MA among the semi-rigid ring, semi-rigid band, and flexible ring. Results Before annuloplasty (n = 61), the AL–PM diameter was significantly larger (ED: 4.26 ± 0.08 vs. ES: 4.24 ± 0.07, p = 0.016) and the sphericity index was significantly smaller (ED: 0.93 ± 0.01 vs. ES: 0.94 ± 0.01, p = 0.017) at ED than at ES. Table 1 shows the analysis after annuloplasty for each device. After annuloplasty, not every group demonstrated significant differences in AL–PM diameter or sphericity index. MA dynamics were reduced equally with the three devices. Conclusion Mitral annuloplasty reduced MA dynamics equally when using a semi-rigid ring, semi-rigid band, and flexible ring. There were no distinctive differences among the three devices in terms of maintaining flexibility and a saddle-shaped geometry. MV dynamics after mitral annuloplasty Semi-rigid ring (n = 33) Flexible band (n = 21) Semi-rigid band (n = 7) ES ED P value ES ED P value ES ED P value AP (cm) 2.61 ± 0.38 2.67 ± 0.44 0.15 2.61 ± 0.38 2.67 ± 0.44 0.15 2.79 ± 0.44 2.80 ± 0.43 0.75 AL-PM (cm) 2.85 ± 0.31 2.91 ± 0.39 0.20 2.85 ± 0.31 2.91 ± 0.39 0.20 2.70 ± 0.39 2.73 ± 0.42 0.15 Height (cm) 0.49 ± 0.20 0.51 ± 0.21 0.35 0.63 ± 0.17 0.62 ± 0.17 0.48 0.63 ± 0.13 0.63 ± 0.13 1.00 SI 0.92 ± 0.09 0.92 ± 0.09 0.45 0.91 ± 0.09 0.91 ± 0.08 0.85 0.95 ± 0.12 0.95 ± 0.11 0.34 AHCWR(%) 17.1 ± 6.65 17.4 ± 6.67 0.56 20.4 ± 5.00 20.2 ± 5.10 0.52 21.3 ± 4.49 21.3 ± 4.80 0.95 Data are expressed mean ± standard deviation. AP: anterior posterior; AL-PM: anterolateral-posteromedial; SI: Sphericity index; AHCWR: annular height to commissure width ratio; ES: endsystole; ED: enddiastole. Abstract P1531 Figure

Published
2020
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88. Recent Improvements at Hosokura Lead Smelter and Refinery

Author

S. Ito, S. Abe, H. Nakano, and N. Hasegawa

Subjects
High concentration, Waste management, Wastewater, Smelting, Oil refinery, Environmental science, Metal mining, Lead smelting, Refinery, Working environment
Abstract

Hosokura Metal Mining Co., Ltd., operates as a secondary lead smelter and refinery, which produces about 30,000 tons of electric lead per year from waste lead-acid batteries and lead residue generated in copper smelters and refineries. Wastewater from the closed lead and zinc mines and tailing dams is also treated. Since 2017, our company has carried out a 10-year future plan, which focuses on themes such as safe working environment, compliance, and optimization of lead smelting and refining business. This paper reports on major topics about the plan, such as “Improvement of working environment around furnaces”, “Treatment of wastewater containing fluorine at high concentration”, “Rationalization of the closed mines monitoring”, and “Improvements of separation work of waste lead-acid battery”.

Published
2020
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93. Local extensive granulomatous inflammation of the neck region and lymphangitis caused by Lichtheimia corymbifera infection in a Japanese Black calf

Author

A.P.P. Teh, S. Ito, H. Furukawa, Y. Goto, Yuichi Hidaka, Ryoji Yamaguchi, J. Sawada, and Takuya Hirai

Subjects
Pathology, medicine.medical_specialty, 040301 veterinary sciences, Lichtheimia corymbifera, Case Report, Microbiology, 0403 veterinary science, Granulomatous inflammation, Medicine, Mucormycosis, lcsh:QH301-705.5, Histological examination, lcsh:R5-920, business.industry, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Bovine, Retropharyngeal region, medicine.disease, 040201 dairy & animal science, Lateral neck, Infectious Diseases, Lymphangitis, lcsh:Biology (General), Lymphogenous route, business, lcsh:Medicine (General), Fungal hyphae
Abstract

A 7-month-old female Japanese Black calf developed elongated, nodular mass measuring 30 × 16 cm extended from the retropharyngeal region to mid lateral neck region. Histological examination revealed granulomatous lymphangitis with non-septate fungal hyphae recognized throughout the lesions. Fungal culture, DNA sequencing and molecular phylogenetic tree analysis confirmed the sequence of Lichtheimia corymbifera. The lymphogenous route was speculated to be the main route of fungal spread leading to the characteristic nodular appearance of this case. Keywords: Bovine, Lichtheimia corymbifera, Lymphogenous route, Mucormycosis

Published
2018

94. Real-Time Lossless Compression of Waveforms Using an FPGA

Author

S. Ito, H. Natori, Y. Igarashi, Y. Seiya, D. Nagao, Yohei Nakatsugawa, Nguyen Minh Truong, Koji Yamamoto, Masaharu Aoki, N. Teshima, and M. Saito

Subjects
Lossless compression, Nuclear and High Energy Physics, 010308 nuclear & particles physics, business.industry, Firmware, Bandwidth (signal processing), computer.software_genre, 01 natural sciences, Data acquisition, Nuclear Energy and Engineering, Gate array, 0103 physical sciences, Compression ratio, Waveform, Electrical and Electronic Engineering, business, Field-programmable gate array, computer, Computer hardware
Abstract

High-energy physics experiments must usually handle large transfer rates of experimental data. In particular, in recent years, the amount and speed of data handled in high-energy physics experiments have significantly increased, because signal waveforms from detectors are often recorded without reduction to maximize the flexibility of the offline analysis. To best exploit the available bandwidth of such data acquisition systems with waveform recording, we developed the real-time lossless waveform-compression firmware that is based on a delta-encoding technique. The firmware provides a compression ratio of 34% of the raw data produced, the fast analog-to-digital converter (FADC) boards of our application before transmission to a host computer. The resource consumption of a field-programmable gate array (FPGA) is not large, and a low-cost mid-range FPGA is sufficient to implement this proposed firmware. The firmware has been successfully implemented on an FADC board and was utilized to record signals from multiwire proportional chambers for the DeeMe experiment. In this paper, we present the theory related to the firmware design and its implementation on the FPGA.

Published
2018
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95. Stability and linearity of luminescence imaging of water during irradiation of proton-beams and X-ray photons lower energy than the Cerenkov light threshold

Author

Masataka Komori, Seiichi Yamamoto, Yuho Hirata, Toshiyuki Toshito, Shuji Koyama, Junki Tada, Kenichi Watanabe, S. Ito, and Takuya Yabe

Subjects
Physics, Nuclear and High Energy Physics, Range (particle radiation), Photon, Proton, X-ray, Linearity, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Irradiation, Atomic physics, Luminescence, Instrumentation, Physics::Atmospheric and Oceanic Physics
Abstract

Luminescence of water during irradiations of proton-beams or X-ray photons lower energy than the Cerenkov-light threshold is promising for range estimation or the distribution measurements of beams. However it is not yet obvious whether the intensities and distributions are stable with the water conditions such as temperature or addition of solvable materials. It remains also unclear whether the luminescence of water linearly increases with the irradiated proton or X-ray energies. Consequently we measured the luminescence of water during irradiations of proton-beam or X-ray photons lower energy than the Cerenkov-light threshold with different water conditions and energies to evaluate the stability and linearity of luminescence of water. We placed a water phantom set with a proton therapy or X-ray system, luminescence images of water with different conditions and energies were measured with a high-sensitivity cooled charge coupled device (CCD) camera during proton or X-ray irradiations to the water phantom. In the stability measurements, imaging was made for different temperatures of water and addition of inorganic and organic materials to water. In the linearity measurements for the proton, we irradiated with four different energies below Cerenkov light threshold. In the linearity measurements for the X-ray, we irradiated X-ray with different supplied voltages. We evaluated the depth profiles for the luminescence images and evaluated the light intensities and distributions. The results showed that the luminescence of water was quite stable with the water conditions. There were no significant changes of intensities and distributions with the different temperatures. Results from the linearity experiments showed that the luminescence of water linearly increased with their energies. We confirmed that luminescence of water is stable with conditions of water. We also confirmed that the luminescence of water linearly increased with their energies.

Published
2018
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96. Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation ― The Hokuriku-Plus AF Registry ―

Author

Kenshi, Hayashi, Toyonobu, Tsuda, Akihiro, Nomura, Noboru, Fujino, Atsushi, Nohara, Kenji, Sakata, Tetsuo, Konno, Chiaki, Nakanishi, Hayato, Tada, Yoji, Nagata, Ryota, Teramoto, Yoshihiro, Tanaka, Masa-Aki, Kawashiri, Masakazu, Yamagishi, and S, Ito

Subjects
Adult, Male, medicine.medical_specialty, medicine.drug_class, 030204 cardiovascular system & hematology, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Thromboembolism, Internal medicine, Atrial Fibrillation, Natriuretic Peptide, Brain, medicine, Natriuretic peptide, Humans, Registries, cardiovascular diseases, Stroke, Aged, Proportional Hazards Models, Aged, 80 and over, Heart Failure, business.industry, Incidence, Incidence (epidemiology), Hazard ratio, Atrial fibrillation, General Medicine, Middle Aged, medicine.disease, Confidence interval, Survival Rate, Heart failure, Cohort, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

BACKGROUND B-type natriuretic peptide (BNP) may be a predictor of stroke risk in patients with nonvalvular atrial fibrillation (NVAF); because heart failure is associated with the incidence of stroke in AF patients. However, limited data exist regarding the association between BNP at baseline and risks of thromboembolic events (TE) and death in NVAF patients. Methods and Results We prospectively studied 1,013 NVAF patients (725 men, 72.8±9.7 years old) from the Hokuriku-plus AF Registry to determine the relationship between BNP at baseline and prognosis among Japanese NVAF patients. During the follow-up period (median, 751 days); 31 patients experienced TE and there were 81 cases of TE/all-cause death. For each endpoint we constructed receiver-operating characteristic curves that gave cutoff points of BNP for TE (170 pg/mL) and TE/all-cause death (147 pg/mL). Multivariate analysis with the Cox-proportional hazards model indicated that high BNP was significantly associated with risks of TE (hazard ratio [HR] 3.86; 95% confidence interval [CI] 1.83-8.67; P=0.0003) and TE/all-cause death (HR 2.27; 95% CI 1.45-3.56; P=0.0003). Based on the C-index and net reclassification improvement, the addition of BNP to CHA2DS2-VASc statistically improved the prediction of TE. CONCLUSIONS In a real-world cohort of Japanese NVAF patients, high BNP was significantly associated with TE and death. Plasma BNP might be a useful biomarker for these adverse clinical events.

Published
2018
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97. Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

Author

M. Franklin, Gavin Davies, Lorenzo Santi, Y. Scheglov, A. Ruiz, K. Yi, Ping-Kun Teng, Jan Stark, S. Carrillo, Martin Grunewald, Milos Lokajicek, Darien Wood, S. Blessing, P. F. Ding, Scott Snyder, Jonathan Wilson, M. Herndon, Cecilia Elena Gerber, Luigi Marchese, Cecile Deterre, M. Lancaster, Tiehui Ted Liu, Prabhakar Palni, R. St. Denis, A. Fauré, Nikos Varelas, Sally Seidel, C. L. McGivern, Bing Zhou, P. Barria, D. A. Stoyanova, G. Piacentino, L. Brigliadori, Sergey Burdin, Chen Zhou, S. Bhatia, C. Royon, G. Ginther, M. H.L.S. Wang, Taegil Bae, M. C. Cousinou, Pierfrancesco Butti, Y. Seiya, G. Gomez, Christoph Paus, M. Cooke, S. Cihangir, Robert Hirosky, I. Howley, Fumihiko Ukegawa, Kristian Harder, A. Anastassov, Don Lincoln, Erich Varnes, Y. N. Kharzheev, Suyong Choi, P. H. Garbincius, A. Das, P. Svoisky, L. Oakes, S. Fuess, L. Pondrom, Jianming Qian, B. Kilminster, B. Casal, Pietro Marino, Giorgio Bellettini, R. Wallny, Hui Li, M. J. Shochet, Ron Lipton, Y. Sakurai, Virgil E Barnes, John Christian Freeman, K. Devaughan, Andreas Werner Jung, F. Ptohos, A. Elagin, Peter Wagner, Gueorgui Velev, Elliot Lipeles, K. Potamianos, DongHee Kim, S. Rolli, A. Di Canto, Marcelo Vogel, Hugh Williams, M. Iori, Robert Kehoe, Graham Wilson, Massimo Casarsa, W. H. Hopkins, Jongmin Lee, Lidija Zivkovic, Y. D. Oh, A. Kumar, Howard Scott Budd, Christopher Clarke, W. Ketchum, Philip Baringer, Hyun-Chul Kim, T. Kurca, A. Evdokimov, J. Kraus, Matthias Schott, K. Herner, J. Budagov, V. Gavrilov, S. Banerjee, T. Wright, Matthew T Jones, Aliaksandr Pranko, Gordon Watts, Romain Madar, D. Jang, N. Moggi, B. Di Ruzza, Ashutosh Kotwal, N. K. Mondal, Ting Miao, D. Boline, H. T. Diehl, M. Vesterinen, Jieun Kim, Andrew Askew, S. W. Lee, M. M. Deninno, Markus Wobisch, G. Latino, J. Zennamo, A. Dubey, Michael Mulhearn, A. Loginov, L. Feng, G. Golovanov, T. Kamon, Jay Dittmann, S. Amerio, T. Kuhr, A. Simonenko, L. S. Vertogradov, W. Geng, P. Lukens, Boris Tuchming, V. Glagolev, D. Stentz, A. S. Ito, T. Aaltonen, B. Hoeneisen, D. J. Cox, Q. Liu, D. Cruz, C. Bromberg, J. Clutter, Maxim Perfilov, R. McNulty, M. Hare, A. Drutskoy, J. K. Lim, A. Lucà, K. Pitts, Y. T. Tsai, C. Pagliarone, A. Boehnlein, Mark Raymond Adams, D. Karmanov, H. Hegab, V. Parihar, E. De La Cruz-Burelo, Stefano Giagu, John Hobbs, M. Hohlfeld, Antonio Boveia, Gregorio Bernardi, B. Carls, V. Sorin, A. Mazzacane, A. V. Popov, R. D. Schamberger, J. T. Linnemann, U. K. Yang, J. Nachtman, A. S. Santos, E. Brucken, Phillip Gutierrez, Frederic Deliot, G. P. Yeh, Douglas Benjamin, C. S. Moon, D. Menezes, Stanislav Tokár, Kohei Yorita, D. Glenzinski, Hal Evans, T. Head, D.P. Brown, Seo-Young Noh, P. Mazzanti, J. R. Smith, G. B. Yu, J. Ellison, Emanuela Barberis, Yuji Enari, K. Soustruznik, Elemer Nagy, S. Y. Jun, G. Savage, T. G. Zhao, W. Ye, V. Aushev, J. Conway, Thomas Ferbel, M. Prewitt, Nazar Stefaniuk, Yuji Takeuchi, J. Weichert, Song-Ming Wang, Y. Aushev, G. Grenier, F. Miconi, E. Kajfasz, A. P. Heinson, J. Boudreau, Jose Andres Garcia-Gonzalez, Kazuhiro Yamamoto, M. Savitskyi, Andrew Brandt, L. Bellantoni, A. Ivanov, S. Dutt, S. Caughron, C. Galloni, J. Nett, J. Warchol, J. Konigsberg, A. Kasmi, Pavol Bartos, L. Bagby, Oleg Brandt, Bjoern Penning, Franco Rimondi, Maria Rescigno, H. E. Fisk, D. Lucchesi, W. Ashmanskas, Sudhir Malik, L. Ristori, Ia Iashvili, Adrian Buzatu, J. Keung, G. C. Blazey, D. Torretta, L. Nodulman, A. Sukhanov, Andrew Beretvas, Brajesh C Choudhary, V. V. Lipaev, J. Lellouch, M. A. Pleier, A. Alton, T. Nigmanov, A. Mukherjee, R. Forrest, Giovanni Busetto, Y. Sudo, I. Suslov, Maxim Goncharov, Kunitaka Kondo, Richard D Field, V. E. Bazterra, N. Khalatyan, R. Ruchti, Thibault Guillemin, P. D. Grannis, P. Jiang, R. Yamada, P. Mehtala, Sandra Leone, P. Totaro, I. Ripp-Baudot, Hao Song, L. Scodellaro, J. Orduna, T. Yoshida, Manfredi Ronzani, Sinead Farrington, Andrea Bocci, D. Li, V. L. Malyshev, A. Y. Verkheev, Jeffrey A. Appel, S. Lammel, Giovanni Punzi, O. Norniella, Manfred Paulini, Manuela Campanelli, V. A. Kuzmin, H. Wolfmeister, Fabrice Couderc, F. Badaud, F. Happacher, B. Baldin, N. d’Ascenzo, M. Borysova, Sung Keun Park, Guillelmo Gomez-Ceballos, M. Titov, Christopher George Tully, Aran Garcia-Bellido, K. Hatakeyama, Young-Jin Kim, R. Illingworth, D. Mietlicki, Mitchell Wayne, H. Schellman, S. Torre, J. M. Kohli, L. Ortolan, D. Cauz, W. E. Cooper, A. Jayasinghe, P. Slattery, V. Giakoumopoulou, A. Sánchez-Hernández, S. Poprocki, E. Gramellini, William Wester, Adam Aurisano, S. J. De Jong, C. Hensel, P. Skubic, Joey Huston, P. Wittich, Ziqing Hong, Katsufumi Sato, O. Gogota, B. Jayatilaka, Daniel R Claes, R. Vilar, B. Auerbach, Liang Li, M. Corbo, Jean-Arcady Meyer, Davit Chokheli, J. Y. Han, F. Margaroli, O. Gonzalez Lopez, A. Bhatti, D. Hedin, F. Devoto, S. Leo, M. Mussini, V. Rusu, L. Welty-Rieger, Marc Besancon, Stefan Grünendahl, Elizaveta Shabalina, M. J. Morello, S. R. Hou, P. E. Karchin, A. Chapelain, S. Errede, Eugene E. Schmidt, Emily Johnson, D. Yamato, A. Golossanov, Vaia Papadimitriou, Alessandro Cerri, A. Mitra, Marco Verzocchi, G. Flanagan, J. P. Agnew, Dmitri Tsybychev, P. Lebrun, Yongsun Kim, Lev Dudko, Nikos Giokaris, A. Grohsjean, Y. C. Chen, V. Saveliev, Dmitri Denisov, J. Russ, Stephen R. Hahn, M. Kurata, R. Madrak, M. Buehler, J. Naganoma, L. Sonnenschein, L. Demortier, Chris Hays, Seog Oh, J. Sekaric, Michael A. Strauss, Maxwell Chertok, A. Patwa, H. Gerberich, J. Joshi, J. Martínez-Ortega, Yang Yang, Zdenek Hubacek, E. Palencia, Giorgio Chiarelli, R. E. Hughes, J. Antos, B. A. Barnett, Giorgio Apollinari, Pedro G Mercadante, S. Atkins, G. Pauletta, Adam L. Lyon, J. P. Negret, Victor Daniel Elvira, K. R. Bland, K. Takemasa, V. M. Podstavkov, P. F. Shepard, Arnaud Duperrin, Carlos Avila, K. Lannon, Eric B James, E. J. Jeon, F. Vázquez, D. Waters, Kazuhiko Hara, M. Fortner, A. Chandra, Satoru Uozumi, U. Bassler, S. Kim, Mark Edward Mattson, Alberto Annovi, S. Zucchelli, Ulrich Heintz, S. Söldner-Rembold, M. Eads, Kenneth Johns, J. Vizán, Marcia Begalli, M. Jaffré, C. A. Cox, Joseph Haley, H. Miyake, J. L. Holzbauer, Kihyeon Cho, Yoshikazu Nagai, P. N. Ratoff, Y. Peters, J. Franc, R. Luna-Garcia, Mousumi Datta, J. Lueck, Lucio Cerrito, R. Roser, Frank Filthaut, Regina Demina, Meenakshi Narain, J. Yoh, F. Bedeschi, T. Harrington-Taber, Y. Zeng, N. Prokopenko, M. Kambeitz, Mark Richard James Williams, Michael Hildreth, W. M. Lee, H. Greenlee, Claus P. Buszello, Ph Gris, T. Hoang, Yujiro Funakoshi, M. Diesburg, Darren Price, Hang Yin, A. Bross, R. Magaña-Villalba, G. Chen, J. Snow, A. A. Shchukin, E. Gerchtein, Fedor Prokoshin, H. T. Nguyen, M. Hussein, S. Z. Shalhout, R. Nayyar, S. Uzunyan, V. Bhatnagar, Alexander Kupco, Emilien Chapon, V. Simak, P. de Barbaro, T. Okusawa, T. Scanlon, T. Yang, Guennadi Borissov, J. Strologas, Y. A. Yatsunenko, Arnd Meyer, T. Rodriguez, James Nugent Bellinger, M. Cordelli, S. Kermiche, Anthony Ross, Shabnam Jabeen, Savanna Marie Shaw, Suman Bala Beri, Barry Blumenfeld, B. L. Winer, T. Tomura, Frank Fiedler, J. Asaadi, M. Merkin, Pierluigi Catastini, S. Chakrabarti, I. Katsanos, M. Dorigo, I. Heredia-De La Cruz, E. E. Boos, N. Parua, M. Tecchio, D. Toback, Arnulf Quadt, Alexander Khanov, R. Carosi, Alfred Goshaw, V. Hynek, A. Hocker, R. Bernhard, Amnon Harel, C. Schwanenberger, U. Husemann, Heriberto Castilla-Valdez, W. C. Fisher, W. Parker, M. Kaur, V. V. Tokmenin, G. Alkhazov, Charles Plager, Roman Lysak, S. Donati, K. Matera, D. Amidei, J. M. Yu, Karen Ruth Gibson, Antonio Limosani, P. Rubinov, M. Vidal, D. Vilanova, M. Cremonesi, Q. Z. Li, Lev Uvarov, V. M. Abazov, P. Wilson, Naoki Kimura, Mark Kruse, Alison Lister, I. Kiselevich, Bobby Samir Acharya, H. A. Neal, V. Shary, Daniela Bortoletto, S. Wilbur, C.M. Ginsburg, Pushpalatha C Bhat, Raymond Brock, K. Yip, S. H. Kim, D. V. Bandurin, Raymond Lloyd Culbertson, Jeremy Lys, R. Van Kooten, Neeti Parashar, J. Hogan, A. Juste, K. Petridis, T. Nunnemann, R. Beuselinck, W-M. Yao, Todd Adams, Javier Cuevas, V. Thukral, Jason Dhia Mansour, S. Greder, Iain Alexander Bertram, G. Chlachidze, Yanwen Liu, H. Frisch, A. K.A. Maciel, Lee Sawyer, C. Vellidis, S. Moed, K. Goulianos, Y. Xie, Fabrizio Scuri, J. P. Fernández Ramos, P. Giromini, Michal Kreps, A. Artikov, I. Razumov, M. Zielinski, A. Barbaro-Galtieri, M. D. Corcoran, Gianluca Introzzi, W. Badgett, M. Stancari, Arie Bodek, J. Hays, G. Gutierrez, P. Renton, Evelyn Thomson, V. N. Evdokimov, Th. Müller, M. Rominsky, M. Shimojima, K. Sliwa, P. Neustroev, Sabine Lammers, N. Osman, Liyuan Han, Jakub Cúth, A. Driutti, G. Lungu, R. Jesik, Kyung Kwang Joo, D. Edmunds, R. Lopes De Sá, M. J. Kim, Duncan Carlsmith, Thomas J. Phillips, Andrew Mehta, Zhenyu Ye, Yuri Gershtein, S. Lockwitz, Andrea Castro, A. T. Laasanen, G. D. Alexeev, Flera Rizatdinova, E. Camacho-Pérez, I. Yu, Reinhard Schwienhorst, A. M. Zanetti, Stefano Camarda, Jean-Francois Grivaz, G. Manca, J. Pilot, Arthur Barry Wicklund, Michael S. Gold, Kwok Ming Chan, Yuriy Ilchenko, X. Lei, Daniel Whiteson, Paolo Maestro, Michael H Kirby, A. Jonckheere, A. Semenov, F. Ruffini, A. Lobodenko, M. P. Sanders, B. Esham, M. Brochmann, Aidan Robson, A. Melnitchouk, S. Behari, Daria Zieminska, M. D'Errico, Y. Kato, J. Guimaraes Da Costa, D. Tonelli, A. Napier, T. R. Wyatt, I. V. Gorelov, Zhenbin Wu, R. Erbacher, P. Jonsson, Kamil Augsten, A. Pal, S. W. Youn, Thomas Hebbeker, J. M. Hauptman, A. Kharchilava, Siqi Yang, Elisabetta Pianori, I. Shreyber-Tecker, O. Shkola, Federico Sforza, Brad Abbott, Pierre Petroff, Gregory R Snow, Sergey Denisov, Viviana Cavaliere, G. Sajot, Horst Severini, Hakjae Lee, W. M. Van Leeuwen, Junjie Zhu, Joe Kroll, B. C.K. Casey, S. Wolbers, P. Lujan, Monica D'Onofrio, T. R. Junk, G. Petrillo, J. Tang, Jonathan Lewis, S. Uvarov, Marvin Johnson, Philip Schlabach, M. Trovato, A. V. Kozelov, Jonathan L. 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E., Borissov, G., Bortoletto, D., Borysova, M., Boudreau, J., Boveia, A., Brandt, A., Brandt, O., Brigliadori, L., Brochmann, M., Brock, R., Bromberg, C., Bross, A., Brown, D., Brucken, E., Bu, X. B., Budagov, J., Budd, H. S., Buehler, M., Buescher, V., Bunichev, V., Burdin, S., Burkett, K., Busetto, G., Bussey, P., Buszello, C. P., Butti, P., Buzatu, A., Calamba, A., Camacho-Perez, E., Camarda, S., Campanelli, M., Canelli, F., Carls, B., Carlsmith, D., Carosi, R., Carrillo, S., Casal, B., Casarsa, M., Casey, B. C. K., Castilla-Valdez, H., Castro, A., Catastini, P., Caughron, S., Cauz, D., Cavaliere, V., Cerri, A., Cerrito, L., Chakrabarti, S., Chan, K. M., Chandra, A., Chapelain, A., Chapon, E., Chen, G., Chen, Y. C., Chertok, M., Chiarelli, G., Chlachidze, G., Cho, K., Cho, S. W., Choi, S., Chokheli, D., Choudhary, B., Cihangir, S., Claes, D., Clark, A., Clarke, C., Clutter, J., Convery, M. E., Conway, J., Cooke, M., Cooper, W. E., Corbo, M., Corcoran, M., Cordelli, M., Couderc, F., Cousinou, M. -C., Cox, C. A., Cox, D. J., Cremonesi, M., Cruz, D., Cuevas, J., Culbertson, R., Cuth, J., Cutts, D., Das, A., D'Ascenzo, N., Datta, M., Davies, G., de Barbaro, P., de Jong, S. J., De La Cruz-Burelo, E., Deliot, F., Demina, R., Demortier, L., Deninno, M., Denisov, D., Denisov, S. P., D'Errico, M., Desai, S., Deterre, C., Devaughan, K., Devoto, F., Di Canto, A., Di Ruzza, B., Diehl, H. T., Diesburg, M., Ding, P. F., Dittmann, J. R., Dominguez, A., Donati, S., D'Onofrio, M., Dorigo, M., Driutti, A., Drutskoy, A., Dubey, A., Dudko, L. V., Duperrin, A., Dutt, S., Eads, M., Ebina, K., Edgar, R., Edmunds, D., Elagin, A., Ellison, J., Elvira, V. D., Enari, Y., Erbacher, R., Errede, S., Esham, B., Evans, H., Evdokimov, A., Evdokimov, V. N., Farrington, S., Faure, A., Feng, L., Ferbel, T., Fernandez Ramos, J. P., Fiedler, F., Field, R., Filthaut, F., Fisher, W., Fisk, H. E., Flanagan, G., Forrest, R., Fortner, M., Fox, H., Franc, J., Franklin, M., Freeman, J. C., Frisch, H., Fuess, S., Funakoshi, Y., Galloni, C., Garbincius, P. H., Garcia-Bellido, A., Garcia-Gonzalez, J. A., Garfinkel, A. F., Garosi, P., Gavrilov, V., Geng, W., Gerber, C. E., Gerberich, H., Gerchtein, E., Gershtein, Y., Giagu, S., Giakoumopoulou, V., Gibson, K., Ginsburg, C. M., Ginther, G., Giokaris, N., Giromini, P., Glagolev, V., Glenzinski, D., Gogota, O., Gold, M., Goldin, D., Golossanov, A., Golovanov, G., Gomez, G., Gomez-Ceballos, G., Goncharov, M., Gonzalez Lopez, O., Gorelov, I., Goshaw, A. T., Goulianos, K., Gramellini, E., Grannis, P. D., Greder, S., Greenlee, H., Grenier, G., Gris, Ph., Grivaz, J. -F., Grohsjean, A., Grosso-Pilcher, C., Grunendahl, S., Grunewald, M. W., Guillemin, T., da Costa, J. Guimarae, Gutierrez, G., Gutierrez, P., Hahn, S. R., Haley, J., Han, J. Y., Han, L., Happacher, F., Hara, K., Harder, K., Hare, M., Harel, A., Harr, R. F., Harrington-Taber, T., Hatakeyama, K., Hauptman, J. M., Hays, C., Hays, J., Head, T., Hebbeker, T., Hedin, D., Hegab, H., Heinrich, J., Heinson, A. P., Heintz, U., Hensel, C., Heredia-De La Cruz, I., Herndon, M., Herner, K., Hesketh, G., Hildreth, M. D., Hirosky, R., Hoang, T., Hobbs, J. D., Hocker, A., Hoeneisen, B., Hogan, J., Hohlfeld, M., Holzbauer, J. L., Hong, Z., Hopkins, W., Hou, S., Howley, I., Hubacek, Z., Hughes, R. E., Husemann, U., Hussein, M., Huston, J., Hynek, V., Iashvili, I., Ilchenko, Y., Illingworth, R., Introzzi, G., Iori, M., Ito, A. S., Ivanov, A., Jabeen, S., Jaffre, M., James, E., Jang, D., Jayasinghe, A., Jayatilaka, B., Jeon, E. J., Jeong, M. S., Jesik, R., Jiang, P., Jindariani, S., Johns, K., Johnson, E., Johnson, M., Jonckheere, A., Jones, M., Jonsson, P., Joo, K. K., Joshi, J., Jun, S. Y., Jung, A. W., Junk, T. R., Juste, A., Kajfasz, E., Kambeitz, M., Kamon, T., Karchin, P. 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Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Department of Physics, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Gomez-Ceballos, Guillelmo, Goncharov, Maxim, Paus, Christoph M. E., Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Physique de Clermont ( LPC ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), Institut Pluridisciplinaire Hubert Curien ( IPHC ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), Institut de Physique Nucléaire de Lyon ( IPNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Abazov, V.M., Acharya, B.S., Agnew, J.P., Alexeev, G.D., Appel, J.A., Bandurin, D.V., Barnes, V.E., Barnett, B.A., Bartlett, J.F., Beri, S.B., Besançon, M., Bhat, P.C., Bland, K.R., Boos, E.E., Bu, X.B., Budd, H.S., Buszello, C.P., Camacho-Pérez, E., Casey, B.C.K., Chan, K.M., Chen, Y.C., Cho, S.W., Convery, M.E., Cooper, W.E., Cousinou, M.-C., Cox, C.A., Cox, D.J., De Barbaro, P., De Jong, S.J., Déliot, F., Denisov, S.P., Diehl, H.T., Ding, P.F., Dittmann, J.R., Dudko, L.V., Elvira, V.D., Evdokimov, V.N., Fauré, A., Fernández Ramos, J.P., Fisk, H.E., Freeman, J.C., Garbincius, P.H., García-González, J.A., Garfinkel, A.F., Gerber, C.E., Ginsburg, C.M., González López, O., Goshaw, A.T., Grannis, P.D., Grivaz, J.-F., Grünendahl, S., Grünewald, M.W., Guimaraes Da Costa, J., Hahn, S.R., Han, J.Y., Harr, R.F., Hauptman, J.M., Heinson, A.P., Hildreth, M.D., Hobbs, J.D., Holzbauer, J.L., Hughes, R.E., Ito, A.S., Jaffré, M., Jeon, E.J., Jeong, M.S., Joo, K.K., Jun, S.Y., Jung, A.W., Junk, T.R., Karchin, P.E., Kharzheev, Y.N., Kim, D.H., Kim, H.S., Kim, J.E., Kim, M.J., Kim, S.H., Kim, S.B., Kim, Y.J., Kim, Y.K., Kohli, J.M., Kong, D.J., Kotwal, A.V., Kozelov, A.V., Kurča, T., Kuzmin, V.A., Laasanen, A.T., Lee, H.S., Lee, J.S., Lee, S.W., Lee, W.M., Lewis, J.D., Li, Q.Z., Lim, J.K., Lipaev, V.V., Lopes De Sa, R., Lucà, A., Lyon, A.L., Maciel, A.K.A., Magaña-Villalba, R., Malyshev, V.L., Martínez-Ortega, J., Mattson, M.E., McCarthy, R., McGivern, C.L., McNulty, R., Meijer, M.M., Mercadante, P.G., Mondal, N.K., Moon, C.S., Morello, M.J., Neal, H.A., Negret, J.P., Nguyen, H.T., Noh, S.Y., Oh, S.H., Oh, Y.D., Park, S.K., Pétroff, P., Phillips, T.J., Pleier, M.-A., Podstavkov, V.M., Popov, A.V., Ratoff, P.N., Redondo Fernández, I., Rosner, J.L., Sakumoto, W.K., Sánchez-Hernández, A., Sanders, M.P., Santos, A.S., Schamberger, R.D., Schmidt, E.E., Shalhout, S.Z., Shchukin, A.A., Shepard, P.F., Smith, J.R., Snider, F.D., Snow, G.R., Söldner-Rembold, S., St Denis, R., Stoyanova, D.A., Teng, P.K., Tokmenin, V.V., Tsai, Y.-T., Van Leeuwen, W.M., Varnes, E.W., Vasilyev, I.A., Vázquez, F., Verkheev, A.Y., Vertogradov, L.S., Vizán, J., Wahl, H.D., Wang, M.H.L.S., Wang, S.M., Wester, W.C., Wicklund, A.B., Williams, H.H., Williams, M.R.J., Wilson, G.W., Wilson, J.S., Winer, B.L., Wood, D.R., Wyatt, T.R., Yang, U.K., Yang, Y.C., Yao, W.-M., Yatsunenko, Y.A., Yeh, G.P., Youn, S.W., Yu, G.B., Yu, J.M., Zanetti, A.M., Zhao, T.G., Clark, Allan Geoffrey, Lister, Alison, Wu, Xin, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
Top quark, Tevatron, General Physics and Astronomy, pair production [top], 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), DZERO, Subatomic Physics, ddc:550, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Quantum Chromodynamics, Batavia TEVATRON Coll, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), media_common, Physics, scattering [anti-p p], Particle properties, 02 Physical Sciences, rapidity: difference, CDF, top-quark, difference [rapidity], asymmetry [angular distribution], kinematics, Physical Sciences, top: pair production, Quark, Particle physics, General Physics, angular distribution: asymmetry, Tevatron Collider, media_common.quotation_subject, Physics, Multidisciplinary, FOS: Physical sciences, Forward backward, ddc:500.2, Hadron-hadron interactions, Asymmetry, Computer Science::Digital Libraries, 114 Physical sciences, Marie curie, CDF Collaboration, anti-p p: colliding beams, Physics and Astronomy (all), [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], 0103 physical sciences, anti-p p: scattering, media_common.cataloged_instance, ddc:530, High Energy Physics, European union, 010306 general physics, Science & Technology, 1960 GeV-cms, 010308 nuclear & particles physics, hep-ex, High Energy Physics::Phenomenology, Q007TFB, Research council, Experimental High Energy Physics, High Energy Physics::Experiment, colliding beams [anti-p p], High Energy Physics, Top quark, Hadron-hadron interactions, Quantum Chromodynamics, Particle properties, Tevatron Collider, D0 Collaboration, experimental results
Abstract

The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of √s=1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is At¯tFB=0.128±0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions., Physical Review Letters, 120 (4), ISSN:0031-9007, ISSN:1079-7114

Published
2018
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98. Randomized clinical trial of duct-to-mucosa versus invagination pancreaticojejunostomy after pancreatoduodenectomy

Author

Y. Shimizu, Seiji Natsume, Yoshiki Senda, S Ito, Keitaro Matsuo, Tsuyoshi Sano, Tetsuya Abe, and Koji Komori

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, 030230 surgery, Anastomosis, Pancreaticoduodenectomy, law.invention, Pancreatic Fistula, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Randomized controlled trial, law, Pancreaticojejunostomy, Clinical endpoint, Humans, Medicine, Aged, Aged, 80 and over, Pancreatic duct, business.industry, Surrogate endpoint, Invagination, Length of Stay, Middle Aged, medicine.disease, Surgery, Treatment Outcome, medicine.anatomical_structure, Pancreatic fistula, 030220 oncology & carcinogenesis, Female, business
Abstract

Background The postoperative pancreatic fistula (POPF) rate for duct-to-mucosa and invagination anastomosis after pancreatoduodenectomy is still debated. The aim of this RCT was to investigate the POPF rate for duct-to-mucosa versus invagination pancreaticojejunostomy. Methods Patients were stratified by pancreatic texture and diameter of the main pancreatic duct and randomized to the duct-to-mucosa or invagination group. The primary endpoint was the rate of clinically relevant POPF (defined as grade B or C). Secondary endpoints were suture material cost for pancreaticojejunostomy, drain insertion duration and duration of postoperative hospital stay. Results Some 120 patients undergoing pancreatoduodenectomy were included following consent. Clinically relevant POPF developed in six of 59 patients (10 per cent) in the invagination group and in 14 of 61 patients (23 per cent) in the duct-to-mucosa group (P = 0·077). Duration of drain insertion (6 versus 7 days respectively; P = 0·027) and postoperative hospital stay (19 versus 24 days; P = 0·015) were shorter in the invagination group. Subgroup analysis for 61 patients with a soft pancreas revealed a lower rate of clinically relevant POPF in the invagination group (10 per cent versus 42 per cent in the duct-to-mucosa group; P = 0·010). Among 20 patients with a clinically relevant POPF, the six patients in the invagination group had a shorter duration of drain insertion (38·5 days versus 49 days for 14 patients in the duct-to-mucosa group; P = 0·028) and postoperative hospital stay (42 versus 54·5 days respectively; P = 0·028). Conclusion This study did not demonstrate a superiority of invagination over duct-to-mucosa pancreaticojejunostomy in the risk of POPF. However, in high-risk patients with a soft pancreas, invagination may reduce the risk of clinically relevant POPF compared with duct-to-mucosa. Registration number: UMIN000005890 (http://www.umin.ac.jp).

Published
2017
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99. Energetic analyses of installing SOFC co-generation systems with EV charging equipment in Japanese cafeteria

Author

Tadashi Tanaka, K. Akiba, S. Ito, M. Yashiro, Yoshitaka Inui, H. Osaki, and H. Kamiko

Subjects
Co generation, Engineering, High energy, biology, Renewable Energy, Sustainability and the Environment, business.industry, 020209 energy, Electrical engineering, Energy Engineering and Power Technology, Cafeteria, 02 engineering and technology, 021001 nanoscience & nanotechnology, biology.organism_classification, Automotive engineering, Water heater, Fuel Technology, Nuclear Energy and Engineering, Installation, Backup, 0202 electrical engineering, electronic engineering, information engineering, Energy supply, 0210 nano-technology, business, Heat pump water heater
Abstract

Energetic feasibility analyses were conducted when an SOFC CGS with EV charging equipment is installed in a facility with a high hot-water demand and a high thermo-electric demand ratio. The university cafeteria located on the Hitachi Campus of Ibaraki University in Japan was selected as an installation target because its electric and hot-water demands fulfilled the intended criterion of a high thermo-electric demand ratio. It was made clear that the merits of a co-generation system are not optimal in the case a gas water heater is selected as the backup hot-water supply. To solve the problems contributing to this bad result and to improve the performance, the authors next selected a heat pump water heater as the backup hot-water supply. It was made clear that this system possesses sufficiently high energy savings performance. It was also shown that the coexistence and co-prosperity of the cafeteria and EV charging equipment are successfully achieved. These results reveal that an SOFC CGS with EV charging equipment can be a feasible candidate for a future energy supply system installed in Japanese cafeteria, which is a facility with a large hot-water demand and a high thermo-electric demand ratio, by adopting a heat pump water heater, instead of the usual gas water heater, as the backup hot-water supply.

Published
2017
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