210 results on '"Sánchez-Sánchez, C."'
Search Results
52. Chlor–Alkali Industry: A Laboratory Scale Approach
- Author
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Sánchez-Sánchez, C. M., primary, Expósito, E., additional, Frías-Ferrer, A., additional, González-García, J., additional, Montiel, V., additional, and Aldaz, A., additional
- Published
- 2004
- Full Text
- View/download PDF
53. Nutrición transpilórica en el niño críticamente enfermo. Réplica de los autores
- Author
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López-Herce Cid, J, primary and Sánchez Sánchez, C, additional
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- 2004
- Full Text
- View/download PDF
54. Estudio de la postura sedente en una población infantil
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Quintana Aparicio, E., primary, Martín Nogueras, A., additional, Sánchez Sánchez, C., additional, Rubio López, I., additional, López Sendín, N., additional, and Calvo Arenillas, J.I., additional
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- 2004
- Full Text
- View/download PDF
55. Calculation of the Characteristic Performance Indicators in an Electrochemical Process
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Sánchez-Sánchez, C. M., primary, Expósito, E., additional, Solla-Gullón, J., additional, García-García, V., additional, Montiel, V., additional, and Aldaz, A., additional
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- 2003
- Full Text
- View/download PDF
56. Colitis colágena y atrofia vellositaria del intestino delgado: ¿manifestaciones de una misma enfermedad?
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Vera Méndez, F.J., primary, Hallal Hachem, H., additional, Barón Saura, J.M., additional, Sánchez Sánchez, C., additional, Pérez Guillermo, M., additional, Conesa Pallarés, J., additional, and García Henarejos, J.A., additional
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- 2003
- Full Text
- View/download PDF
57. Protocolo diagnóstico del paciente con sospecha de enfermedad del sistema nervioso autónomo
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Sánchez Sánchez, C., primary
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- 2003
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- View/download PDF
58. Trastornos del sistema nervioso autónomo
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Sánchez Sánchez, C., primary
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- 2003
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- View/download PDF
59. Electrochemical approaches to alleviation of the problem of carbon dioxide accumulation
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Sánchez-Sánchez, C. M., primary, Montiel, V., additional, Tryk, D. A., additional, Aldaz, A., additional, and Fujishima, A., additional
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- 2001
- Full Text
- View/download PDF
60. Actuación fisioterápica en el proceso educativo del deporte base
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Martín Nogueras, A., primary, Calvo Arenillas, J.I., additional, Orejuela Rodrígue, J., additional, Barbero Iglesias, F.J., additional, Sánchez Sánchez, C., additional, and Méndez Sánchez, R., additional
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- 2001
- Full Text
- View/download PDF
61. Ventilación mecánica no invasiva en la hipoventilación alveolar central congénita
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López-Herce Cid, J., primary, Moreno de Guerra Girón, M., additional, Sánchez Sánchez, C., additional, and Carrillo Álvarez, A., additional
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- 2000
- Full Text
- View/download PDF
62. Valence band electronic structure characterization of the rutile TiO2 (110)-(1×2) reconstructed surface
- Author
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Sánchez-Sánchez, C., Garnier, M.G., Aebi, P., Blanco-Rey, M., de Andres, P.L., Martín-Gago, J.A., and López, M.F.
- Subjects
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VALENCE (Chemistry) , *ELECTRONIC structure , *RUTILE , *TITANIUM oxides , *SURFACES (Technology) , *PHOTOELECTRON spectroscopy , *SYMMETRY (Physics) , *BAND gaps - Abstract
Abstract: The electronic structure of the TiO2 (110)-(1×2) surface has been studied by means of angular resolved ultraviolet photoemission spectroscopy (ARUPS). The valence band dispersion along the high symmetry surface directions, [001] and [1–10], has been recorded. The experimental data show no dispersion of the band-gap Ti 3d states. However, the existence of dispersive bands along the [001] direction located at about 7eV below the Fermi level is reported. The existence of two different contributions in the emission from the defects-related state located in the gap of the surface is univocally shown for the first time. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
63. Small Pt nanoparticles on the TiO2 (110)–(1×2) surface
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Sánchez-Sánchez, C., Martín-Gago, J.A., and López, M.F.
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PLATINUM nanoparticles , *TITANIUM dioxide , *SURFACE chemistry , *SCANNING tunneling microscopy , *AGGLOMERATION (Materials) , *METAL clusters , *ANNEALING of metals - Abstract
Abstract: Scanning tunnelling microscopy (STM) has been used to study the initial stages of Pt deposition on the TiO2 (110)–(1×2) surface. Experimental STM images recorded for Pt coverage of 0.1 and 0.4 ML, suggest a Volmer-Weber growth. For low coverage and RT deposition, small clusters homogeneously distributed on the surface terraces are observed. However, after annealing at 825K, material agglomeration, with nucleation mainly at the cross-links, is observed as a consequence of Pt diffusion on the surface. Finally, the structure of small clusters has been determined, in good agreement with previous theoretical calculations. [Copyright &y& Elsevier]
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- 2013
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64. Pancreatitis aguda: nuestra experiencia.
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Martínez López, M. C., Miranda Herrero, M. C., Hernando Puente, M., Tolín Hernani, M., Sánchez Sánchez, C., and Álvarez Calatayud, G.
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PANCREATITIS ,AMYLASES ,ABDOMINAL pain in children ,ENDOSCOPIC retrograde cholangiopancreatography ,EPIDEMIOLOGY - Abstract
Copyright of Acta Pediátrica Española is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2013
65. Thermal behaviour of the O2/TiO2 (110)–(1 × 2) surface
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Abad, J., Sánchez-Sánchez, C., Vilmercati, P., Goldoni, A., López, M.F., and Martin-Gago, J.A.
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THERMAL properties , *TITANIUM dioxide , *SURFACE chemistry , *SYNCHROTRON radiation , *ULTRAVIOLET radiation , *PHOTOEMISSION , *ELECTRONIC structure , *OXYGEN - Abstract
Abstract: Synchrotron radiation ultra-violet photoemission at different photon energies (17.1, 19.3, and 21.5 eV) has been used to study the interaction of O2 with the TiO2 (110)–(1 × 2) surface reconstruction at temperatures between 77 and 320 K. At 77 K the results show a weak molecular chemisorption of the O2 molecule on the surface. By analysing the thermal behaviour of the O2/TiO2 system in a temperature range from 77 to 320 K, it has been found that between 120 and 200 K the O2 molecule is dissociated. [Copyright &y& Elsevier]
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- 2011
- Full Text
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66. Prevalence of asymptomatic peripheral artery disease in patients with non-cardioembolic ischemic stroke,Prevalencia de enfermedad arterial periférica asintomática en pacientes con ictus isquémico no cardioembólico
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Álvarez-Sabín, J., Gil-Núñez, A., Quintana, M., Barbera, G., Alonso Leciñana Cases, M., Calleja Puerta, S., Casado Naranjo, I., Díez Tejedor, E., Escamilla Crespo, C., Fernández Fernández, O., Gállego Cullere, J., Lago Martín, A., López Fernández, J. C., Maestre Moreno, J., Martí-Fábregas, J., Martín González, R., Obach Tuca, V., Rebollo Álvarez-Amandi, M., Romero López, J., Rubio Borrego, F., Gómez Díaz-Castroverde, A., Vidal Sánchez, J. A., Moris La Tassa, G., Tejada García, J., Timiraos Fernández, J. J., Pérez Concha, T., Revilla García, M. A., Guereca Baranaiarn, L., Urtasunocariz, M., Ríos Gómez, C., Tejero Juste, C., García Gómara, M. J., Bravo Anguiano, Y., Gil Pujades, A., Palacios Marchesini, M., García Sánchez, S., Cano Orgaz, A., Purroy García, F., Obach Baurier, V., Arboix Damunt, A., Sanclemente Ansó, C., Rey Pérez, A., Canovas Verge, D., Fabregat Fabra, N., Rodríguez Campello, A., Comas Bergua, P., Cardona Cortela, P., Garcés Redondo, M., Robles Del Olmo, B., Olivella Rius, J., Martínez Ramírez, S., Torres Rodríguez, M. J., Pareja Martínez, A., Chamarro Lázaro, R., Pons Amate, J. M., Romero Martínez, M. A., Galiano Blancart, R. F., Vilar Fabra, C., Domínguez Sanz, F., Gracia Fleta, F., Plaza Macías, I., Villaverde González, R., Salamero Martínez, J. J., Medrano Martínez, V., Tortosa Conesa, D., Soria Torrecillas, J. J., Marey López, J., Romero López, J. M., Lustres Pérez, M., Ortega Casarrubios, M. A., Egido Herrero, J. A., Ruiz Ezquerro, J. J., Gómez Sánchez, J. C., Martín Polo, J., Gutiérrez Martin, F., Calleja Sanz, A. I., Peñas Martínez, M. L., Rojo Martínez, E., López Manzanares, L., Domingo García, J., García Castañón, I., Díaz Guzmán, J., Hernández Gallego, J. M., Sánchez Sánchez, C., Eimil Ortiz, M., González Santiago, R., Zabala Goiburu, J. A., Sánchez Del Valle, O., Morín Martín, M. M., Jiménez Caballero, P. E., Ferrero Ros, M., Vallejo Maroto, I., Gil Peralta, A., Aguilera Navarro, J. M., Carmona Nimo, E., García Moreno, J. M., Cueli Rincón, B., Hernández Ramos, F., Martínez Laso, A., Pilo La Fuente, B., Puerto Alonso, J. L., Tamayo Toledo, J. A., Moya Molina, M. A., Márquez Martínez, M., Gálvez Gálvez, C., Girón Úbeda, J. M., Del Saz Saucedo, P., Fernández Pérez, M. D., Antonio Arjona-Padillo, Olivares Romero, J., Peinado Cantero, M. L., Villegas Rodríguez, I., Vega Pérez, J. M., Maestre Martínez, M. A., Portillo Rivero, M. R., Sánchez Ortiz, C., Ochoa Sepúlveda, J. J., Bescansa Heredero, E., Vega López, O., Suárez Cuervo, A., Pueyo Morlans, M., Medina Rodríguez, A., Sáenz Galván, C., Marrero Falcón, C., and Mirdavood, S.
67. Evaluation of growth and tolerance to modified formula for infants with minor digestive disorders in Primary Care | Valoración del crecimiento y tolerancia de fórmula modificada para lactantes con trastornos digestivos menores en Atención Primaria
- Author
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Sánchez Sánchez, C., Losada, A., Llorente Hernández, C., Cuéter Mendoza, J. C., Esplugues Cortell, J. R., Ferri Sastre, E., Matínez Pedanyé, D., Quiles Antón, A., González Pérez, J. M., González-Ripoll Garzón, M., Álvarez Córdoba, A., Delgado Cardoso, M., Gómez Málaga, C. M., Hernández Carballo, C., López Valero, G. N., Pérez Civantos, J., Santos Ruiz, I., Achaval Rodríguez, V., Arigón Gaudiano, P., Barco Rubio, J., Conejero Romagosa, J., Edo Valdovi, D., Electrico Persico, A., Elnayef Elnayef, H., García Henares, A. M., Giménez Subiñá, E., Gimeno Pita, P., Goyanes Sotelo, C. S., Guimaraes Mazpule, I., Laporte Ocaña, R., León Marín, I., Llobera Bauzá, M. J., López Lorite, A. M., Marco García, M., Martín, P. K., Martín Lázaro, A., Martínez Ortiz, J. L., Martorell Aymeric, J., Moriyón Gotera, J., Olmo González, M., Ortolá Castells, M. E., Picorell Novo, M. E., Reta Atozqui, G., Rodrigo González Liria, A., Rodriguez Alsina, S., Roldán Ros, A. M., Rueda Muñoz, A., Sánchez Rosell, M., Sancho Suárez, M., Torres Sancho, J., Vallbona Zubizarreta, J., Vázquez Rodríguez Alessi, P., Verges Brotons, J., Gómez La Calzada Gutierrez, F., Ibrahim Al- Oman, O., Pires Sánchez, C., Reyes Moreno, A., Rodríguez Barrero, S., Fernández Revuelta, S., Guerrero Vázquez, J., Díaz Entresotos Villazan, L., Fernández Fernández, B., García Calatayud, S., García López, N., Madrigal Díez, C., Ortiz Revuelta, V., Pérez Guerrero, A., Uriarte Higuera, A., Estero Castaño, F. J., Larragay Arredondo, M., Tordera Gómez, P. L., Álvarez Gil, D., La Torre Cecilia, C., Gómez Chaparro Moreno, J. L., Muriel Zafra, M. I., Díaz Castany, C., Díaz Jiménez, C., Talavera Rodríguez, R., Alberdi Alberdi, A., Barral Barral, J., Belloso Balzategui, J., Bervel Clemente, S., Duque Alcuña, G., Muriel Infante, J., Tello Ochoa, J. M., Díaz Vico, M. P., Navarrete Ruiz, I., Rus Tellez, A. M., Torres Conde, J., Torres Torres, A. R., Carcía Cabanas, M. C., López Coronas, D., Maíz Cal, C., Seijo Garea, E. M., Bernad Usoz, J. V., Gutiérrez Rodríguez, J., Alonso García, L. A., Alonso Ortiz, T., Satray San-Martín, A., La Vega Jiménez, F., Del Palacio Mestres, C., Díaz González, C., Fernández-Criado Bedoya, M., Galiano Segovia, M. J., Garde Morales, M. T., Giménez Abián, M. A., González Villaumborsía García, C., González Onandia, P., Jabón Serradilla, A., Jordán Martínez, J., Kheiri Amin, I., Martínez Mosquera, J. G., Molero Díaz, F. J., Montequi Fitera, J. C., Montero Reguera, R., Noya Beiroa, M. E., Pamero López, A., Riquelme Pérez, M., Rodríguez Pérez, N., Saínz Ruiz, R., Sánchez Castresana, Chileme López, A., Rodríguez Aysa, G., Torres Magno, E., García Ruiz, A. J., González García, R., Iniesta Mompeaú, R., Orrillo, M. V., Ruiz Lavela, F. M., Villalba García, M. C., Cherrez Muirragui, C., Boullosa, M., González Martínez, A. L., González Sueiro, P., Iglesias González, L., Delgado Ramos, J. A., Fernández Álvarez, A., García Guerrero, A., Parody Ruiz-Berdejo, J., Pérez Faílde, A. M., Ponce González, F. J., Ramos Palma, M. L., Segovia Ferrera, C., Silva Gallardo, J. J., Varela Rubio, E., Aranda Peréz, P., Coca Méndez, R., Abad Balaguer, B., Alcacer Portillo, M. D., Andrés Ferreres, F., Asensi Monzo, M. T., Bröozu Ampudia, Ü, Chavez González, C., Javier Diez-Domingo, Escobar Araico, M. T., Fernández Vázquez, C. L., González González, F., Haro Cárceles, E., Matilla Fernández, A., Royo Bolea, C., Vegas Álvarez, A., La Fuente Juasoro, E., García Saniugarte, L., Hernando Zarate, Z., Juez López, I., Santolaya Jiménez, J., Zaballrerru Isari, F., Andrés Cofino, R., Lillo Prieto, M. M., Niño, F., and Zurita, A.
68. Prevalence of asymptomatic peripheral artery disease in patients with non-cardioembolic ischemic stroke | Prevalencia de enfermedad arterial periférica asintomática en pacientes con ictus isquémico no cardioembólico
- Author
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Jose Alvarez-Sabin, Gil-Núñez, A., Quintana, M., Barbera, G., Álvarez-Sabín, J., Alonso Leciñana Cases, M., Calleja Puerta, S., Casado Naranjo, I., Díez Tejedor, E., Escamilla Crespo, C., Fernández Fernández, O., Gállego Cullere, J., Lago Martín, A., López Fernández, J. C., Maestre Moreno, J., Martí-Fábregas, J., Martín González, R., Obach Tuca, V., Rebollo Álvarez-Amandi, M., Romero López, J., Rubio Borrego, F., Gómez Díaz-Castroverde, A., Vidal Sánchez, J. A., Moris La Tassa, G., Tejada García, J., Timiraos Fernández, J. J., Pérez Concha, T., Revilla García, M. A., Guereca Baranaiarn, L., Urtasunocariz, M., Ríos Gómez, C., Tejero Juste, C., García Gómara, M. J., Bravo Anguiano, Y., Gil Pujades, A., Palacios Marchesini, M., García Sánchez, S., Cano Orgaz, A., Purroy García, F., Obach Baurier, V., Arboix Damunt, A., Sanclemente Ansó, C., Rey Pérez, A., Canovas Verge, D., Fabregat Fabra, N., Rodríguez Campello, A., Comas Bergua, P., Cardona Cortela, P., Garcés Redondo, M., Robles Del Olmo, B., Olivella Rius, J., Martínez Ramírez, S., Torres Rodríguez, M. J., Pareja Martínez, A., Chamarro Lázaro, R., Pons Amate, J. M., Romero Martínez, M. A., Galiano Blancart, R. F., Vilar Fabra, C., Domínguez Sanz, F., Gracia Fleta, F., Plaza Macías, I., Villaverde González, R., Salamero Martínez, J. J., Medrano Martínez, V., Tortosa Conesa, D., Soria Torrecillas, J. J., Marey López, J., Romero López, J. M., Lustres Pérez, M., Ortega Casarrubios, M. A., Egido Herrero, J. A., Ruiz Ezquerro, J. J., Gómez Sánchez, J. C., Martín Polo, J., Gutiérrez Martin, F., Calleja Sanz, A. I., Peñas Martínez, M. L., Rojo Martínez, E., López Manzanares, L., Domingo García, J., García Castañón, I., Díaz Guzmán, J., Hernández Gallego, J. M., Sánchez Sánchez, C., Eimil Ortiz, M., González Santiago, R., Zabala Goiburu, J. A., Sánchez Del Valle, O., Morín Martín, M. M., Jiménez Caballero, P. E., Ferrero Ros, M., Vallejo Maroto, I., Gil Peralta, A., Aguilera Navarro, J. M., Carmona Nimo, E., García Moreno, J. M., Cueli Rincón, B., Hernández Ramos, F., Martínez Laso, A., Pilo La Fuente, B., Puerto Alonso, J. L., Tamayo Toledo, J. A., Moya Molina, M. A., Márquez Martínez, M., Gálvez Gálvez, C., Girón Úbeda, J. M., Del Saz Saucedo, P., Fernández Pérez, M. D., Arjona Padillo, A., Olivares Romero, J., Peinado Cantero, M. L., Villegas Rodríguez, I., Vega Pérez, J. M., Maestre Martínez, M. A., Portillo Rivero, M. R., Sánchez Ortiz, C., Ochoa Sepúlveda, J. J., Bescansa Heredero, E., Vega López, O., Suárez Cuervo, A., Pueyo Morlans, M., Medina Rodríguez, A., Sáenz Galván, C., Marrero Falcón, C., and Mirdavood, S.
69. Physiotherapy treatment in Calcaneal Apophysitis in young footballers,Tratamiento fisioterápico en las apofisitis del calcáneo en futbolistas jóvenes
- Author
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Martín Nogueras, A., Calvo Arenillas, J. I., Moreno Pascual, C., Sánchez Sánchez, C., Roberto Méndez-Sánchez, and Alburquerque Sendín, F.
70. [Vascular risk factors in patients with ischaemic stroke. Distribution according to age, sex and stroke subtype]
- Author
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Vp, Moreno, Aranzazu García Raso, Mj, García-Bueno, Sánchez-Sánchez C, Meseguer E, Mata R, and Llamas P
- Subjects
Male ,Stroke ,Sex Factors ,Risk Factors ,Age Factors ,Humans ,Female ,Aged ,Brain Ischemia - Abstract
Cardiovascular diseases are one of the leading health problems in developed countries. This term covers conditions such as coronary vascular disease, cerebrovascular diseases and peripheral vascular disease. Ischaemic cerebrovascular disease accounts for 80% of all cerebrovascular diseases. From a clinical point of view it is interesting to distinguish between modifiable and non-modifiable vascular risk factors.To analyse the prevalence of modifiable vascular risk factors and their different combinations in a case-control study on ischaemic cerebrovascular disease in the Spanish population, and also the differences in the distribution of the risk factors according to the type of stroke (TOAST classification), age and sex.The study was conducted on 308 patients with ischaemic stroke who were paired by age (+/- 5 years) and sex, with 307 controls with no prior history of thrombosis. The statistical analysis was performed using the software application SAS v. 9.1.The results suggest that the risk factors are subject to an adding effect, as well as pointing to the presence of a specific profile of these factors depending on the subtype of stroke that is developed.The addition of cardiovascular risk factors is associated with an increased risk of vascular events. The distribution of the modifiable vascular risk factors differs according to the type of stroke and the patient's sex and age.
71. UAMCLyR at RepLab 2014: Author Profiling task∗ notebook for RepLab at CLEF 2014
- Author
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ESAU VILLATORO-TELLO, Ramírez-De-La-Rosa, G., Sánchez-Sánchez, C., Jiménez-Salazar, H., Luna-Ramírez, W. A., and Rodríguez-Lucatero, C.
72. Electronic characterization of silicon intercalated chevron graphene nanoribbons on Au(111)
- Author
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Deniz, O., Sánchez-Sánchez, C., Jaafar, R., Kharche, N., Liang, L., Meunier, V., Feng, X., Müllen, K., Fasel, Roman, and Ruffieux, P.
- Subjects
530 Physics ,540 Chemistry ,570 Life sciences ,biology ,7. Clean energy
73. [Is progressive anarthria a clinical form of Pick complex?]
- Author
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Jl, Dobato, Barón-Rubio M, Mc, Valle Juan, Fj, Barriga, Sánchez-Sánchez C, Sánchez del Río M, Pardo-Moreno J, Ja, Pareja, and Lydia Vela-Desojo
- Subjects
Male ,Pick Disease of the Brain ,Humans ,Neuropsychological Tests ,Cognition Disorders ,Speech Disorders ,Temporal Lobe ,Aged ,Frontal Lobe - Abstract
Progressive anarthria is defined as a clinical entity with a degenerative origin consisting in progressive difficulty in articulating while grammatical, semantic and graphic aspects of language are preserved. It is included within the group of processes affecting restricted areas of the brain although its exact nosological location is not clear. We report two cases that progressed clinically towards frontotemporal dementia and corticobasal degeneration, respectively.Case 1: a male who, at the age of 72, began with speech difficulties while comprehension and reading/writing skills were preserved. Three years later he developed apathy, bulimia, sexual indiscretions and aggressiveness, with preservation of visual memory, visual-constructional capacity and elementary writing skills. Case 2: a male who, at the age of 70, began with speech disorders, which were associated two years later to generalised slowness with Hoehn and Yahr stage II akinetic-rigid symptoms; another two years later, he developed a dystonic attitude and melokinetic apraxia in the left upper limb.The two cases, which were initially compatible with progressive anarthria, progressed clinically towards frontotemporal dementia and corticobasal degeneration, which are entities that are included in 'Pick complex'. This is a concept that we believe to be useful from a clinical point of view, given the variability that exists in the histology of the entities that have been proposed as members of this syndrome group, together with the progression of the cases described in the literature and the ones we have reported in this work.
74. Valence band electronic structure characterization of the rutile TiO₂ (110)-(1 × 2) reconstructed surface
- Author
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Sánchez-Sánchez, C., Garnier, M.G., Aebi, Philipp, Blanco-Rey, M., Andres, P.L. de, Martín-Gago, J.A., López, M.F., Sánchez-Sánchez, C., Garnier, M.G., Aebi, Philipp, Blanco-Rey, M., Andres, P.L. de, Martín-Gago, J.A., and López, M.F.
- Abstract
The electronic structure of the TiO₂ (110)-(1 × 2) surface has been studied by means of angular resolved ultraviolet photoemission spectroscopy (ARUPS). The valence band dispersion along the high symmetry surface directions, [001] and [1–10], has been recorded. The experimental data show no dispersion of the band-gap Ti 3d states. However, the existence of dispersive bands along the [001] direction located at about 7 eV below the Fermi level is reported. The existence of two different contributions in the emission from the defects-related state located in the gap of the surface is univocally shown for the first time.
75. Exploring Cognitive Dysfunction in Long COVID Patients: Eye Movement Abnormalities and Frontal-Subcortical Circuits Implications via Eye-Tracking and Machine Learning.
- Author
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Benito-León J, Lapeña J, García-Vasco L, Cuevas C, Viloria-Porto J, Calvo-Córdoba A, Arrieta-Ortubay E, Ruiz-Ruigómez M, Sánchez-Sánchez C, and García-Cena C
- Abstract
Background: Cognitive dysfunction is regarded as one of the most severe aftereffects following coronavirus disease 2019 (COVID-19). Eye movements, controlled by several brain areas, such as the dorsolateral prefrontal cortex and frontal-thalamic circuits, provide a potential metric for assessing cortical networks and cognitive status. We aimed to examine the utility of eye movement measurements in identifying cognitive impairments in long COVID patients., Methods: We recruited 40 long COVID patients experiencing subjective cognitive complaints and 40 healthy controls and used a certified eye-tracking medical device to record saccades and antisaccades. Machine learning was applied to enhance the analysis of eye movement data., Results: Patients did not differ from the healthy controls regarding age, sex, and years of education. However, the patients' Montreal Cognitive Assessment total score was significantly lower than healthy controls. Most eye movement parameters were significantly worse in patients. These included the latencies, gain (computed as the ratio between stimulus amplitude and gaze amplitude), velocities, and accuracy (evaluated by the presence of hypermetric or hypometria dysmetria) of both visually and memory-guided saccades; the number of correct memory saccades; the latencies and duration of reflexive saccades; and the number of errors in the antisaccade test. Machine learning permitted distinguishing between long COVID patients experiencing subjective cognitive complaints and healthy controls., Conclusion: Our findings suggest impairments in frontal subcortical circuits among long COVID patients who report subjective cognitive complaints. Eye-tracking, combined with machine learning, offers a novel, efficient way to assess and monitor long COVID patients' cognitive dysfunctions, suggesting its utility in clinical settings for early detection and personalized treatment strategies. Further research is needed to determine the long-term implications of these findings and the reversibility of cognitive dysfunctions., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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76. Hydrogen-Induced Reduction Improves the Photoelectrocatalytic Performance of Titania.
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Sánchez-Sánchez C, Muñoz R, Alfonso-González E, Barawi M, Martínez JI, López-Elvira E, Sánchez-Santolino G, Shibata N, Ikuhara Y, Ellis GJ, García-Hernández M, López MF, de la Peña O'Shea VA, and Martín-Gago JA
- Abstract
One of the main challenges to expand the use of titanium dioxide (titania) as a photocatalyst is related to its large band gap energy and the lack of an atomic scale description of the reduction mechanisms that may tailor the photocatalytic properties. We show that rutile TiO
2 single crystals annealed in the presence of atomic hydrogen experience a strong reduction and structural rearrangement, yielding a material that exhibits enhanced light absorption, which extends from the ultraviolet to the near-infrared (NIR) spectral range, and improved photoelectrocatalytic performance. We demonstrate that both magnitudes behave oppositely: heavy/mild plasma reduction treatments lead to large/negligible spectral absorption changes and poor/enhanced (×10) photoelectrocatalytic performance, as judged from the higher photocurrent. To correlate the photoelectrochemical performance with the atomic and chemical structures of the hydrogen-reduced materials, we have modeled the process with in situ scanning tunneling microscopy measurements, which allow us to determine the initial stages of oxygen desorption and the desorption/diffusion of Ti atoms from the surface. This multiscale study opens a door toward improved materials for diverse applications such as more efficient rutile TiO2 -based photoelectrocatalysts, green photothermal absorbers for solar energy applications, or NIR-sensing materials., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)- Published
- 2024
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77. Transition mechanism of the coverage-dependent polymorphism of self-assembled melamine nanostructures on Au(111).
- Author
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Zamalloa-Serrano JM, Gómez-Fernández JM, Sánchez-Sánchez C, López MF, Martínez JI, Martín-Gago JÁ, and Palacio I
- Abstract
Molecular self-assembled films have recently attracted increasing attention within the field of nanotechnology as they offer a route to obtain new materials. However, careful selection of the molecular precursors and substrates, as well as exhaustive control of the system evolution is required to obtain the best possible outcome. The three-fold rotational symmetry of melamine molecules and their capability to form hydrogen bonds make them suitable candidates to synthesize this type of self-assembled network. In this work, we have studied the polymorphism of melamine nanostructures on Au(111) at room temperature. We find two coverage-dependent phases: a honeycomb structure (α-phase) for submonolayer coverage and a close-packed structure (β-phase) for full monolayer coverage. A combined scanning tunnel microscopy and density functional theory based-calculations study of the transition regime where both phases coexist allows describing the mechanism underlying this coverage driven phase transition in terms of the changes in the molecular lateral tension.
- Published
- 2024
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78. Somatics and phenomenological psychopathology: a mental health proposal.
- Author
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Sánchez Sánchez C
- Subjects
- Humans, Europe, Mental Health, Psychopathology
- Abstract
This work begins with a brief review - from the physical education movement that began in ancient Greece and is deeply rooted in 19th century Europe, to the somatics movement alive today. The review captures primary historical and conceptual references, relevant to the therapeutic-embodied exploratory work. Then, G. Stanghellini's mental health care model [2] is reviewed. This model is considered within reflexive self-awareness and spoken dialogue: the main vehicles in relation with alterity and its consequences in the realm of psychotherapeutic encounter and intervention. This will highlight the individual's bodily movement and inter-corporeal 'proto-dialogue' as a prior realm of therapeutic intervention. Next, a brief consideration of E. Strauss work [31] is presented. This paper's hypothesis is that bodily qualitative dynamics highlighted by phenomenology are essential for an effective mental health therapeutic intervention. A 'seed' of a framework is proposed in this paper; this seed assesses some phenomenological assets of a positive conception of mental health, for which self-awareness education is key to develop skills such as kinaesthetic intelligence and attunement and to educate healthy persons who can promote edifying social relations and environments., (© 2023. The Author(s).)
- Published
- 2023
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79. Epitaxial growth and characterization of SnSe phases on Au(111).
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Frezza F, Sánchez-Grande A, Ondráček M, Vondráček M, Chen Q, Stetsovych O, Villalobos-Vilda V, Tosi E, Palomares FJ, López MF, Sánchez-Sánchez C, Ernst KH, Martín-Gago JA, Honolka J, and Jelínek P
- Abstract
Two-dimensional (2D) layered group IV-VI semiconductors attract great interest due to their potential applications in nanoelectronics. Depending on the dimensionality, different phases of the same material can present completely different electronic and optical properties, expanding its applications. Here, we present a combined experimental and theoretical study of the atomic structure and electronic properties of epitaxial SnSe structures grown on a metallic Au(111) substrate, forming almost defect-free 2D layers. We describe a coverage-dependent transition from a metallic β -SnSe to a semiconducting α -SnSe phase. The combination of scanning tunneling microscopy/spectroscopy, non-contact atomic force microscopy, x-ray photoelectron spectroscopy/diffraction and angle-resolved photoemission spectroscopy, complemented by density functional theory, provides a comprehensive study of the geometric and electronic structure of both phases. Our work demonstrates the possibility to grow two distinct SnSe phases on Au(111) with high quality and on a large scale. The strong interaction with the substrate allows the stabilization of the previously experimentally unreported β -SnSe, while the ultra-thin films of orthorhombic α -SnSe are structurally and electronically equivalent to bulk SnSe., (Creative Commons Attribution license.)
- Published
- 2023
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80. On-surface synthesis of metal-organic frameworks: the critical role of the reaction conditions.
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Ruiz Del Árbol N, Sánchez-Sánchez C, Martínez JI, Rodríguez L, Serrate D, Verdini A, Floreano L, Jacobson P, Grill L, Martín-Gago JA, and López MF
- Abstract
Two different metal-organic frameworks with either a honeycomb or Kagome structure were grown on Cu(111) using para -aminophenol molecules and native surface adatoms. Although both frameworks are made up from the same chemical species, they are structurally different emphasizing the critical role being played by the reaction conditions during their growth. This work highlights the importance of the balance between thermodynamics and kinetics in the final structure of surface-supported metal-organic networks.
- Published
- 2023
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81. The Role of Metal Adatoms in a Surface-Assisted Cyclodehydrogenation Reaction on a Gold Surface.
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Björk J, Sánchez-Sánchez C, Chen Q, Pignedoli CA, Rosen J, Ruffieux P, Feng X, Narita A, Müllen K, and Fasel R
- Abstract
Dehydrogenation reactions are key steps in many metal-catalyzed chemical processes and in the on-surface synthesis of atomically precise nanomaterials. The principal role of the metal substrate in these reactions is undisputed, but the role of metal adatoms remains, to a large extent, unanswered, particularly on gold substrates. Here, we discuss their importance by studying the surface-assisted cyclodehydrogenation on Au(111) as an ideal model case. We choose a polymer theoretically predicted to give one of two cyclization products depending on the presence or absence of gold adatoms. Scanning probe microscopy experiments observe only the product associated with adatoms. We challenge the prevalent understanding of surface-assisted cyclodehydrogenation, unveiling the catalytic role of adatoms and their effect on regioselectivity. The study adds new perspectives to the understanding of metal catalysis and the design of on-surface synthesis protocols for novel carbon nanomaterials., (© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
- Published
- 2022
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82. [Perforated duodenal ulcer: Endoscopic-conservative management].
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Camuña Correa JI, Toledano Revenga J, Pérez Moreno J, and Sánchez Sánchez C
- Published
- 2022
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83. Refractive outcomes of toric intraocular lens in combined trabecular micro bypass stent implantation and cataract surgery in glaucomatous eyes.
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López-Caballero C, Sánchez-Sánchez C, Puerto B, Blázquez V, Sánchez-Pina JM, and Contreras I
- Subjects
- Humans, Lens Implantation, Intraocular, Refraction, Ocular, Stents, Astigmatism, Cataract, Glaucoma, Lenses, Intraocular, Phacoemulsification
- Abstract
Purpose: To evaluate the impact of trabecular micro bypass stents (iStent Inject) on refractive outcomes with toric intraocular lens (IOL) in glaucomatous eyes., Methods: We identified glaucomatous eyes receiving a toric IOL between October 2017 and December 2020. Eyes with iStent implantation were included in the study group and eyes undergoing isolated phacoemulsification served as controls. Corrected and uncorrected visual acuity, manifest refraction, intraocular pressure (IOP), and number of hypotensive drugs three months after surgery were evaluated., Results: 26 eyes comprised the study group and 41 eyes the control group. Mean postoperative refractive cylinder was 0.26D in the control and 0.11D in the iStent group, with 63% and 85% of eyes with a cylinder of 0 and 85% and 92% of eyes with a cylinder ≤ 0.5D respectively. The mean absolute difference between target and outcome spherical equivalent was 0.26D in the control and 0.22D in the iStent group, with all eyes within 0.75D of target. LogMar uncorrected postoperative vision in eyes targeted for emmetropia was 0.04 in the control and 0.03 in the iStent group. There was a statistically significant reduction in IOP and number of hypotensive drugs in both groups, with a mean decrease in IOP of 8.6% in the control and 15.7% in the iStent group. The number of hypotensive drugs dropped from 1.63 ± 0.80 to 1.34 ± 0.91 in the control group and from 2.12 ± 0.65 to 0.44 ± 0.71 in the iStent group., Conclusion: Toric IOLs provide predictable refractive outcomes in glaucomatous eyes undergoing combined phacoemulsification with iStent implantation, reducing postoperative spectacle dependence., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
- Published
- 2022
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84. Development of real-time PCR methods for the quantification of Methanoculleus, Methanosarcina and Methanobacterium in anaerobic digestion.
- Author
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Sánchez-Sánchez C, Aranda-Medina M, Rodríguez A, Hernández A, Córdoba MG, Cuadros-Blázquez F, and Ruiz-Moyano S
- Subjects
- Anaerobiosis, Archaea genetics, Bioreactors, Methane, Methanosarcina genetics, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Methanobacterium genetics, Methanomicrobiaceae genetics
- Abstract
Anaerobic digestion is a growing technology to manage organic waste and produce bioenergy. To promote this technology, it is essential to know, at the molecular level, the dynamics of microbial communities, specifically the methanogenic community. In the present study, three primer pairs were selected from seven primer pairs which were designed and tested with different concentrations and conditions to detect Methanosarcina, Methanoculleus and Methanobacterium by real-time PCR based on the SYBR Green System. The functionality of the developed methods was demonstrated by the high linear relationship of the standard curves, and the specificity of each primer was empirically verified by testing DNA isolated from methane-producing and non-producing strains. These assays also exhibited good repeatability and reproducibility, which indicates the robustness of the methods. The described primers were successfully used to investigate the methanogenic communities of 10 samples from an anaerobic co-digestion. The genus Methanosarcina was the dominant methanogenic group., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
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85. Is the Predisposition to Have More Children Beneficial among Parents with Only One Child? Evidence from Spanish Parents.
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Gómez-Ortiz O and Sánchez-Sánchez C
- Subjects
- Adult, Child, Preschool, Disease Susceptibility, Female, Humans, Male, Personality, Personality Disorders, Social Support, Parenting psychology, Perfectionism
- Abstract
The fertility deficit in many European countries is related to a low rate of second births. Understanding the factors associated with the predisposition of one-child parents to have more children could contribute to the search for solutions to this social problem. Although previous evidence highlights the role of employment and social factors, psychological factors have been poorly investigated. This study examines the relationship between different psychosocial factors (rumination, personality, life satisfaction, perfectionism, social support, parental stress, guilt linked to work-family conflict, age and child temperament) and parents' predisposition to have more children. The sample consisted of 96 one-child Spanish parents whose child was in early childhood education (59.3% women; M
age = 37.41). The results show that one-child parents with the predisposition to have more children, compared to those without a predisposition to have more children, showed higher levels of life satisfaction, extroversion and adaptive perfectionism but lower levels of rumination and parental stress. The social implications of these findings and how they may affect parenting today are discussed.- Published
- 2022
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86. Cross-cultural adaptation and psychometric validation of a Spanish version of the revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire.
- Author
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de Juan-Roldán JI, Castillo-Jimena M, González-Hevilla A, Sánchez-Sánchez C, García-Ruiz AJ, and Gavilán-Moral E
- Subjects
- Aged, Attitude, Cross-Cultural Comparison, Cross-Sectional Studies, Humans, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, Deprescriptions
- Abstract
Objectives: Successful deprescribing depends largely on factors related to the patient. The revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire was developed with the objective of evaluating the beliefs and attitudes of older adults and caregivers towards deprescribing. The present study was designed to validate a Spanish version of the rPATD questionnaire, both the versions for older adults and for caregivers, through a qualitative validation phase and the analysis of its psychometric properties., Design: Cross-sectional validation study., Setting: Primary care settings in Málaga (Spain)., Participants: A sample of 120 subjects (60 patients with polypharmacy and 60 caregivers of patients with polypharmacy) were enrolled in the study., Main Outcome Measures: In the qualitative validation stage, the rPATD questionnaire was translated/back-translated and subjected to a cross-cultural adaptation to evaluate its face validity and feasibility. Next, its psychometric properties were assessed. Confirmatory factor analysis was used to evaluate construct validity. Internal consistency was determined using Cronbach's alpha test. Criterion validity through pre-established hypotheses from the Beliefs about Medicines Questionnaire (BMQ) Specific-Concerns Scale, and test-retest reliability were analysed., Results: Confirmatory factor analysis verified the four-factor structure of the original rPATD questionnaire, with items loading into four factors: involvement , burden , appropriateness and concerns about stopping . The Cronbach's alpha coefficient of the factors ranged from 0.683 to 0.879. The burden , appropriateness and concerns about stopping factors were significantly correlated with the BMQ Specific-Concerns Score, except for the concerns about stopping factor in the older adults' version. The consistency of the items between administration times (test-retest reliability) showed weighted Cohen's kappa values ranging from moderate (>0.4) to very good (>0.8)., Conclusions: The Spanish version of the rPATD questionnaire is a feasible, valid and reliable instrument to evaluate attitudes towards deprescribing in Spanish-speaking patients and caregivers., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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87. On-Surface Thermal Stability of a Graphenic Structure Incorporating a Tropone Moiety.
- Author
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Márquez IR, Ruíz Del Árbol N, Urgel JI, Villalobos F, Fasel R, López MF, Cuerva JM, Martín-Gago JA, Campaña AG, and Sánchez-Sánchez C
- Abstract
On-surface synthesis, complementary to wet chemistry, has been demonstrated to be a valid approach for the synthesis of tailored graphenic nanostructures with atomic precision. Among the different existing strategies used to tune the optoelectronic and magnetic properties of these nanostructures, the introduction of non-hexagonal rings inducing out-of-plane distortions is a promising pathway that has been scarcely explored on surfaces. Here, we demonstrate that non-hexagonal rings, in the form of tropone (cycloheptatrienone) moieties, are thermally transformed into phenyl or cyclopentadienone moieties upon an unprecedented surface-mediated retro-Buchner-type reaction involving a decarbonylation or an intramolecular rearrangement of the CO unit, respectively.
- Published
- 2022
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- View/download PDF
88. Prevalence of Burnout Syndrome and Job Satisfaction in Music Therapists in Spain: A Cross-Sectional, Descriptive Study.
- Author
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Sequera-Martín M, Ramos-Fuentes MI, Garrido-Ardila EM, Sánchez-Sánchez C, de la Torre-Risquez A, and Rodríguez-Mansilla J
- Subjects
- Adult, Burnout, Psychological, Cross-Sectional Studies, Female, Humans, Job Satisfaction, Male, Prevalence, Spain epidemiology, Surveys and Questionnaires, Burnout, Professional epidemiology, Music
- Abstract
Background: Burnout syndrome and job satisfaction are topics of increasing interest due to their relevance in people's health and well-being. Besides, they are considered very relevant in the fields of social and health care studies., Objective: The objective of this study was to analyse the professional profile of music therapists in Spain and the prevalence of burnout syndrome and job satisfaction among them., Methods: This was an observational, descriptive, cross-sectional study, carried out using an ad-hoc online questionnaire, the Maslach Scale and the general satisfaction scale on a sample of employed Spanish music therapists with more than two years of working experience in Spain., Results: Eighty questionnaires were analysed. The majority of the participants were between 30-39 years old (38.8%) and were women (85%). They combined their profession with other occupations (76.3%), mostly in care roles with a fix term contract and were self-employed (40%). The prevalence of burnout syndrome was 3.8% ( p < 0.001) and the predisposition or tendency to develop this condition was over 57.5% ( p < 0.001). The highest levels of burnout syndrome were found in professionals with trainee contracts ( p = 0.001), in those who were providing training ( p = 0.021), who attended 6 to 10 patients per week ( p = 0.001), who were usually working with a therapist colleague ( p = 0.046) and those who did not take prescribed psychotropic drugs ( p = 0.034). The highest level of job satisfaction was observed in music therapists working in the field of disability ( p = 0.010) and mental health ( p = 0.022) and with seniority in their job position. The lowest level of job satisfaction was seen in music therapists with trainee contracts ( p = 0.041), with less working hours per week ( p = 0.016), working in the field of education ( p = 0.006) and in those who did not feel valued by their colleagues ( p < 0.001) or by the director of the centre where they worked ( p < 0.001)., Conclusions: Based on the results of this study, Spanish music therapists show a low prevalence of burnout syndrome but a moderate-high predisposition to develop it. Music therapists with burnout syndrome are those who work longer hours and perform their job in palliative care setting. In general, music therapists have a high level of both intrinsic and extrinsic job satisfaction. The lowest level of job satisfaction was found in music therapists with trainee contracts and the highest in music therapists with senior positions.
- Published
- 2021
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89. Visual Function and Patient Satisfaction with Multifocal Intraocular Lenses in Patients with Glaucoma and Dry Age-Related Macular Degeneration.
- Author
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Sánchez-Sánchez C, Rementería-Capelo LA, Puerto B, López-Caballero C, Morán A, Sánchez-Pina JM, and Contreras I
- Abstract
Purpose: To report visual function and self-reported satisfaction of patients with glaucoma and dry age-related macular degeneration (dAMD) implanted with multifocal intraocular lenses (MIOL)., Methods: Patients with glaucoma or dAMD as well as healthy individuals implanted with MIOL were invited to participate. Explorations performed were uncorrected and corrected distance visual acuity (UDVA and CDVA), low-contrast visual acuity (LCVA), binocular contrast sensitivity, and defocus curves. Patients completed the Catquest-9 questionnaire and reported on the presence of dysphotopsias and the need for spectacles., Results: 38 subjects were included: 11 in the healthy/control group and 9 each in the preperimetric glaucoma, perimetric glaucoma, and dAMD groups. Controls had statistically better monocular UDVA, CDVA, and LCVA than patients with glaucoma and dAMD, as well as better binocular acuity in the defocus curves between -2.00 D and +0.50 D. Differences between controls and patients with preperimetric glaucoma were not statistically significant. Between -3.0 D and +0.5 D, all groups except dAMD achieved acuities better than 0.2 logMAR. Patients with dAMD had worse contrast sensitivity than all others for 3 cycles per degree (cpd), and patients with glaucoma had worse values than all others for 12 cpd; other differences did not reach statistical significance. Healthy subjects and patients with preperimetric glaucoma perceived halos more often than patients with glaucoma or dAMD, while suffering less from glare. Patients with glaucoma and dAMD found more difficulties when driving at night and required spectacles for near more often than the other subjects. Patients with dAMD were less satisfied with their vision., Conclusions: MIOLs may be implanted in patients with preperimetric glaucoma with little fear of patient dissatisfaction. In glaucoma and dAMD, MIOLs might be considered with caution, after explaining the increased risk of glare and the higher need for spectacle correction for reading., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Carmen Sánchez-Sánchez et al.)
- Published
- 2021
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90. SARS-COV-2 infection in pregnant women and newborns in a Spanish cohort (GESNEO-COVID) during the first wave.
- Author
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Carrasco I, Muñoz-Chapuli M, Vigil-Vázquez S, Aguilera-Alonso D, Hernández C, Sánchez-Sánchez C, Oliver C, Riaza M, Pareja M, Sanz O, Pérez-Seoane B, López J, Márquez E, Domínguez-Rodríguez S, Hernanz-Lobo A, De León-Luis JA, Sánchez-Luna M, and Navarro ML
- Subjects
- Adult, Anti-Bacterial Agents therapeutic use, Antiviral Agents therapeutic use, COVID-19 physiopathology, COVID-19 therapy, COVID-19 Nucleic Acid Testing, Cesarean Section statistics & numerical data, Cohort Studies, Comorbidity, Cough physiopathology, Diabetes, Gestational epidemiology, Dyspnea physiopathology, Female, Fever physiopathology, Gestational Age, Humans, Hypertension epidemiology, Hypothyroidism epidemiology, Immunologic Factors therapeutic use, Infant, Newborn, Infectious Disease Transmission, Vertical, Intensive Care Units statistics & numerical data, Lung diagnostic imaging, Male, Obesity, Maternal epidemiology, Pneumonia, Viral diagnostic imaging, Pneumonia, Viral physiopathology, Pneumonia, Viral therapy, Pregnancy, Pregnancy Complications epidemiology, Pregnancy Complications, Infectious physiopathology, Pregnancy Complications, Infectious therapy, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Radiography, Thoracic, Respiration, Artificial, Risk Factors, SARS-CoV-2, Severity of Illness Index, Spain epidemiology, COVID-19 Drug Treatment, COVID-19 epidemiology, Carrier State epidemiology, Pregnancy Complications, Infectious epidemiology, Premature Birth epidemiology
- Abstract
Background: Knowledge about SARS-CoV-2 infection in pregnancy and newborns is scarce. The objective of this study is to analyse clinical and epidemiological characteristics of a cohort of women infected with SARS-CoV-2 during pregnancy and their newborns exposed to SARS-CoV-2 during gestation., Methods: Multicentric observational study of Spanish hospitals from the GESNEO-COVD cohort, participants in RECLIP (Spanish Network of Paediatric Clinical Assays). Women with confirmed SARS-CoV-2 infection by PCR and/or serology during pregnancy, diagnosed and delivering during the period 15/03/2020-31/07/2020 were included. Epidemiological, clinical, and analytical data was collected., Results: A total of 105 pregnant women with a median of 34.1 years old (IQR: 28.8-37.1) and 107 newborns were included. Globally, almost 65% of pregnant women had some COVID-19 symptoms and more than 43% were treated for SARS-COV-2. Overall, 30.8% of pregnant women had pneumonia and 5 (4.8%) women were admitted to the intensive care unit needing invasive mechanical ventilation. There was a rate of 36.2% of caesarean sections, which was associated with pneumonia during pregnancy (OR: 4.203, CI 95%: 1.473-11.995) and lower gestational age at delivery (OR: 0.724, CI 95%: 0.578-0.906). The prevalence of preterm birth was 20.6% and prematurity was associated with pneumonia during gestation (OR: 6.970, CI95%: 2.340-22.750) and having a positive SARS-CoV-2 PCR at delivery (OR: 6.520, CI95%: 1.840-31.790). All nasopharyngeal PCR in newborns were negative at birth and one positivized at 15 days of life. Two newborns died, one due to causes related to prematurity and another of unexpected sudden death during early skin-to-skin contact after delivery., Conclusions: Although vertical transmission has not been reported in this cohort, the prognosis of newborns could be worsened by SARS-CoV-2 infection during pregnancy as COVID-19 pneumonia increased the risk of caesarean section deliveries and preterm births.
- Published
- 2021
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91. Prevalence of advanced heart failure and use of palliative care in admitted patients: Findings from the EPICTER study.
- Author
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Fernández-Martinez J, Romero-Correa M, Salamanca-Bautista P, Aramburu-Bodas Ó, Formiga F, Vázquez-Rodríguez P, Conde-Martel A, García-García JA, Páez-Rubio I, López-Reboiro M, Sánchez-Sánchez C, and Arias-Jiménez JL
- Subjects
- Cross-Sectional Studies, Female, Hospitalization, Humans, Prevalence, Heart Failure diagnosis, Heart Failure epidemiology, Heart Failure therapy, Palliative Care
- Abstract
Introduction and Aim: Palliative care in patients with advanced heart failure is strongly recommended by Clinical Practice Guidelines. We aimed to calculate the prevalence of advanced heart failure in admitted patients, to describe their management, and to analyse the factors that influence their referral to specialised palliative care., Patients and Methods: Cross-sectional, multicentre study that consecutively included patients admitted for heart failure in 74 Spanish hospitals. If they met criteria for advanced heart failure, their treatment, complications and procedures were recorded., Results: A total of 3153 patients were included. Of them, 739 (23%) met criteria for advanced heart failure. They were more likely to be women, older and to have a history of anaemia, chronic kidney disease and cognitive impairment. For their management, furosemide infusions (30%) and vasodilators (21%) were used. Refractory symptoms were treated with opioids (47%) and benzodiazepines (44%). Palliative care was only provided in the last hours of life in 48% of them. A multidisciplinary approach, involving palliative care specialists was sought in 15% of these patients. Treatment with furosemide infusions, an advanced New York Heart Association functional class, to meet advanced HF criteria and the presence of cancer were associated with the referral to specialised palliative care., Conclusions: Almost one in four patients admitted with HF met criteria of advanced disease. They were older and had more comorbidities. Specialist palliative care services were involved in only a minority of patients, mainly those who were highly symptomatic or had cancer., Competing Interests: Declaration of Competing Interest The authors report no relationships that could be construed as a conflict of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2021
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92. Copper-assisted oxidation of catechols into quinone derivatives.
- Author
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Gómez-Herrero AC, Sánchez-Sánchez C, Chérioux F, Martínez JI, Abad J, Floreano L, Verdini A, Cossaro A, Mazaleyrat E, Guisset V, David P, Lisi S, Martín Gago JA, and Coraux J
- Abstract
Catechols are ubiquitous substances often acting as antioxidants, thus of importance in a variety of biological processes. The Fenton and Haber-Weiss processes are thought to transform these molecules into aggressive reactive oxygen species (ROS), a source of oxidative stress and possibly inducing degenerative diseases. Here, using model conditions (ultrahigh vacuum and single crystals), we unveil another process capable of converting catechols into ROSs, namely an intramolecular redox reaction catalysed by a Cu surface. We focus on a tri-catechol, the hexahydroxytriphenylene molecule, and show that this antioxidant is thereby transformed into a semiquinone, as an intermediate product, and then into an even stronger oxidant, a quinone, as final product. We argue that the transformations occur via two intramolecular redox reactions: since the Cu surface cannot oxidise the molecules, the starting catechol and the semiquinone forms each are, at the same time, self-oxidised and self-reduced. Thanks to these reactions, the quinone and semiquinone are able to interact with the substrate by readily accepting electrons donated by the substrate. Our combined experimental surface science and ab initio analysis highlights the key role played by metal nanoparticles in the development of degenerative diseases., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)
- Published
- 2020
- Full Text
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93. On-Surface Driven Formal Michael Addition Produces m-Polyaniline Oligomers on Pt(111).
- Author
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Ruiz Del Árbol N, Sánchez-Sánchez C, Otero-Irurueta G, Martínez JI, de Andrés PL, Gómez-Herrero AC, Merino P, Piantek M, Serrate D, Lacovig P, Lizzit S, Alemán J, Ellis GJ, López MF, and Martín-Gago JA
- Abstract
On-surface synthesis is emerging as a highly rational bottom-up methodology for the synthesis of molecular structures that are unattainable or complex to obtain by wet chemistry. Here, oligomers of meta-polyaniline, a known ferromagnetic polymer, were synthesized from para-aminophenol building-blocks via an unexpected and highly specific on-surface formal 1,4 Michael-type addition at the meta position, driven by the reduction of the aminophenol molecule. We rationalize this dehydrogenation and coupling reaction mechanism with a combination of in situ scanning tunneling and non-contact atomic force microscopies, high-resolution synchrotron-based X-ray photoemission spectroscopy and first-principles calculations. This study demonstrates the capability of surfaces to selectively modify local molecular conditions to redirect well-established synthetic routes, such as Michael coupling, towards the rational synthesis of new covalent nanostructures., (© 2020 The Authors. Published by Wiley-VCH GmbH.)
- Published
- 2020
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94. On-surface Synthesis of a Chiral Graphene Nanoribbon with Mixed Edge Structure.
- Author
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Keerthi A, Sánchez-Sánchez C, Deniz O, Ruffieux P, Schollmeyer D, Feng X, Narita A, Fasel R, and Müllen K
- Abstract
Chiral graphene nanoribbons represent an important class of graphene nanomaterials with varying combinations of armchair and zigzag edges conferring them unique structure-dependent electronic properties. Here, we describe the on-surface synthesis of an unprecedented cove-edge chiral GNR with a benzo-fused backbone on a Au(111) surface using 2,6-dibromo-1,5-diphenylnaphthalene as precursor. The initial precursor self-assembly and the formation of the chiral GNRs upon annealing are revealed, along with a relatively small electronic bandgap of approximately 1.6 eV, by scanning tunnelling microscopy and spectroscopy., (© 2020 The Authors. Published by Wiley-VCH GmbH.)
- Published
- 2020
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95. [Is the diet low in FODMAP really effective and safe for irritable bowel syndrome?: A scoping review].
- Author
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Sebastián Domingo JJ and Sánchez Sánchez C
- Subjects
- Diet, Carbohydrate-Restricted, Disaccharides, Humans, Monosaccharides, Prospective Studies, Irritable Bowel Syndrome
- Abstract
At present, there is no aetiological treatment available for irritable bowel syndrome, and dietary modifications, particularly the low-FODMAP (monosaccharide, disaccharide, oligosaccharides and fermentable polyols) diet is increasingly used to control the symptoms of irritable bowel syndrome, although its actual efficacy and safety are unknown. The objective of this overview is to determine whether the low FODMAP diet is really effective and safe in the long term in the dietary management of irritable bowel syndrome. The review, following an appropriate methodology, was carried out with 25 studies, which were retrieved full text. Of these, 3 were meta-analyses, 2 were systematic reviews, and 3 were both types of studies. The rest of the studies were, in general, of low methodological quality and very heterogeneous, with a low level of evidence and low degree of recommendation. It can be concluded that, in the short term, the low-FODMAP diet is effective in most patients with irritable bowel syndrome, so its use as first-line therapy could be supported. However, of all the studies, only one was prospective for long-term follow-up, between 6 and 18 months, with good results. More follow-up studies, designed for this purpose, are needed to investigate long-term effects. Furthermore, if this type of diet is advised, it should be led by specialised dietitians., (Copyright © 2020. Publicado por Elsevier España, S.L.U.)
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- 2020
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96. Role of the metal surface on the room temperature activation of the alcohol and amino groups of p-aminophenol.
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Del Árbol NR, Palacio I, Sánchez-Sánchez C, Otero-Irurueta G, Martínez JI, Rodríguez L, Serrate D, Cossaro A, Lacovig P, Lizzit S, Verdini A, Floreano L, Martín-Gago JA, and López MF
- Abstract
We present a comparative study of the room-temperature adsorption of p-aminophenol (p-AP) molecules on three metal surfaces, namely Cu(110), Cu(111) and Pt(111). We show that the chemical nature and the structural symmetry of the substrate control the activation of the terminal molecular groups, which result in different arrangements of the interfacial molecular layer. To this aim, we have used in-situ STM images combined with synchrotron radiation high resolution XPS and NEXAFS spectra, and the results were simulated by DFT calculations. On copper, the interaction between the molecules and the surface is weaker on the (111) surface crystal plane than on the (110) one, favouring molecular diffusion and leading to larger ordered domains. We demonstrate that the p-AP molecule undergoes spontaneous dehydrogenation of the alcohol group to form phenoxy species on all the studied surfaces, however, this process is not complete on the less reactive surface, Cu(111). The Pt(111) surface exhibits stronger molecule-surface interaction, inducing a short-range ordered molecular arrangement that increases overtime. In addition, on the highly reactive Pt(111) surface other chemical processes are evidenced, such as the dehydrogenation of the amine group.
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- 2020
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97. Changes in Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer after Femtosecond Laser-Assisted Cataract Surgery Compared to Manual Phacoemulsification in Patients Receiving a Trifocal Intraocular Lens.
- Author
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Sánchez-Sánchez C, Rementería-Capelo LA, Carrillo V, Pérez-Lanzac J, and Contreras I
- Abstract
Introduction: During femtosecond laser-assisted cataract surgery (FLACS), there is a significant increase in intraocular pressure, which might lead to ganglion cell damage. We aimed to determine whether there were differences in the changes produced in the ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness, as evaluated with optical coherence tomography (OCT), between phacoemulsification and FLACS, after implantation of a trifocal intraocular lens (IOL)., Methods: Patients with no coexistent pathologies undergoing cataract surgery with implantation of a PanOptix IOL were explored with the Cirrus-OCT before and three months after surgery. GCC values were obtained from the built-in software. The differences between pre- and postoperative GCC and pRNFL thicknesses after phacoemulsification were compared to differences after FLACS., Results: A total of 171 eyes were included, 74 undergoing FLACS and 97 phacoemulsification. For both groups, there was a statistically significant increase in GCC values after cataract surgery, except for the inferior and inferonasal sectors. There were no statistically significant differences between FLACS and phacoemulsification. Mean change in average GCC and minimum GCC were 1.08 ± 1.40 µ m (range -1 to +6 µ m) and 1.69 ± 2.54 µ m (range -3 to +11 µ m) after FLACS and 0.99 ± 1.67 µ m (range -5 to +6 µ m) and 2.02 ± 3.54 µ m (-6 to +18 µ m) after phacoemulsification. These values are similar to those previously reported after phacoemulsification with monofocal IOL implantation. No significant changes after surgery were detected for the pRNFL, with no differences between groups. Discussion . There were no differences in the changes produced by FLACS and phacoemulsification in either GCC or pRNFL values. Although mean change was small, the range of variation was wide. Therefore, it is necessary to establish a new baseline for GCC and pRNFL thicknesses after cataract surgery in order to monitor any subsequent changes., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Carmen Sánchez-Sánchez et al.)
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- 2020
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98. Is bedtime treatment appropriate for all hypertensive patients?
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Sánchez-Sánchez C, López-Caballero C, Contreras I, Puerto B, and Blazquez-Bermejo Z
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- Chronotherapy, Heart Disease Risk Factors, Humans, Risk Factors, Cardiovascular Diseases, Hypertension drug therapy
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- 2020
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99. Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP.
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Moriczi M, Pujol-Muncunill G, Martín-Masot R, Jiménez Treviño S, Segarra Cantón O, Ochoa Sangrador C, Peña Quintana L, González Santana D, Rodríguez Martínez A, Rosell Camps A, Armas H, Barrio J, González de Caldas R, Rodríguez Salas M, Balmaseda Serrano E, Donat Aliaga E, Bodas Pinedo A, Vaquero Sosa E, Vecino López R, Solar Boga A, Moreno Álvarez A, Sánchez Sánchez C, Tolín Hernani M, Gutiérrez Junquera C, Martinón Torres N, Leis Trabazo MR, Eizaguirre FJ, García Peris M, Medina Benítez E, Fernández Caamaño B, Vegas Álvarez AM, Crespo Valderrábano L, Alonso Vicente C, Rubio Santiago J, Galera-Martínez R, García-Romero R, Ros Arnal I, Fernández Cebrián S, Lorenzo Garrido H, Viada Bris JF, Velasco Rodríguez-Belvis M, Bartolomé Porro JM, Blanco Rodríguez M, Barros García P, Botija G, Chicano Marín FJ, La Orden Izquierdo E, Crehuá-Gaudiza E, Navas-López VM, and Martín-de-Carpi J
- Subjects
- Adolescent, Child, Crohn Disease diagnosis, Crohn Disease metabolism, Female, Humans, Male, Remission Induction, Retrospective Studies, Crohn Disease therapy, Enteral Nutrition
- Abstract
Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014-2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6-8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn's Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (μg/g) decreased significantly after EEN (830 [IQR 500-1800] to 256 [IQR 120-585] p < 0.0001). Patients with wPCDAI ≤ 57.5, FC < 500 μg/g, CRP >15 mg/L and ileal involvement tended to respond better to EEN. EEN administered for 6-8 weeks is effective for inducing clinical remission. Due to the high response rate in our series, EEN should be used as the first-line therapy in luminal paediatric Crohn's disease regardless of the location of disease and disease activity.
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- 2020
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100. Unilateral acute iris depigmentation and transillumination after glaucoma surgery with mitomycin application and intracameral moxifloxacin.
- Author
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Sánchez-Sánchez C, Puerto B, López-Caballero C, and Contreras I
- Abstract
Purpose: Bilateral acute iris depigmentation (BADI) and transillumination (BATI) syndromes have been linked with the use of antibiotics, especially fluoroquinolones. They are characterized by acute onset of pigment dispersion in the anterior chamber, depigmentation of the iris and pigment deposition in the angle and in the posterior surface of the cornea (BADI), with iris transillumination defects and atonic pupil with sphincter paralysis (BATI). The purpose of this paper is to report the development of clinical depigmentation and iris damage similar to BADI and BATI in patients who had undergone uneventful glaucoma surgery with intracameral moxifloxacin as prophylaxis for endophthalmitis., Observations: Four patients who had undergone Ex-Press implantation (cases 1 and 2) or non-penetrating deep sclerotomy (cases 3 and 4) developed asymptomatic pigment dispersion in the anterior chamber, which cleared after treatment with topical corticosteroids and NSAIDS. However, pupillary damage ensued, with mid-midriasis and pigment deposition under the filtration bleb., Conclusions and Importance: This is, to the best of our knowledge, the first report of acute unilateral iris depigmentation and transillumination after intracameral use of moxifloxacin. Moxifloxacin's toxic effect may have been promoted by the subconjuntival mitomycin employed to prevent scarring at the filtration bleb. Surgeons should be aware of these potential side-effects of drugs used as widely as moxifloxacin and mitomycin., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2020 The Authors.)
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- 2020
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