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51. Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency : a prospective randomised trial of a novel hydrocortisone dual-release formulation

Author

Johansson, G., Nilsson, A. G., Bergthorsdottir, R., Burman, P., Dahlqvist, P., Ekman, Bertil, Engström, B. E, Olsson, T., Ragnarsson, O., Ryberg, M., Wahlberg, Jeanette, Biller, B. M. K., Monson, J. P., Stewart, P. M., Lennernäs, H., Skrtic, S., Johansson, G., Nilsson, A. G., Bergthorsdottir, R., Burman, P., Dahlqvist, P., Ekman, Bertil, Engström, B. E, Olsson, T., Ragnarsson, O., Ryberg, M., Wahlberg, Jeanette, Biller, B. M. K., Monson, J. P., Stewart, P. M., Lennernäs, H., and Skrtic, S.

Abstract

Context: Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile. Objective: The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of conventional hydrocortisone tablets. Design and Setting: We conducted an open, randomized, two-period, 12-wk crossover multicenter trial with a 24-wk extension at five university hospital centers. Patients: The trial enrolled 64 adults with primary AI; 11 had concomitant diabetes mellitus (DM). Intervention: The same daily dose of hydrocortisone was administered as OD dual-release or TID. Main Outcome Measure: We evaluated cortisol pharmacokinetics. Results: Compared with conventional TID, OD provided a sustained serum cortisol profile 0-4 h after the morning intake and reduced the late afternoon and the 24-h cortisol exposure. The mean weight (difference = -0.7 kg, P = 0.005), systolic blood pressure (difference = -5.5 mm Hg, P = 0.0001) and diastolic blood pressure (difference: -2.3 mm Hg; P = 0.03), and glycated hemoglobin (absolute difference = -0.1%, P = 0.0006) were all reduced after OD compared with TID at 12 wk. Compared with TID, a reduction in glycated hemoglobin by 0.6% was observed in patients with concomitant DM during OD (P = 0.004). Conclusion: The OD dual-release tablet provided a more circadian-based serum cortisol profile. Reduced body weight, reduced blood pressure, and improved glucose metabolism were observed during OD treatment. In particular, glucose metabolism improved in patients with concomitant DM., Funding Agencies:DuoCort Pharma ABSwedish Foundation of Strategic Research

Published
2012
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52. Anthracycline cardiotoxicity in the elderly cancer patient: a SIOG expert position paper

Author

Aapro, M, Bernard-Marty, C, Brain, E G C, Batist, G, Erdkamp, F, Krzemieniecki, K, Leonard, R, Lluch, Jorge A., Monfardini, S, Ryberg, M, Soubeyran, P, Wedding, U, Aapro, M, Bernard-Marty, C, Brain, E G C, Batist, G, Erdkamp, F, Krzemieniecki, K, Leonard, R, Lluch, Jorge A., Monfardini, S, Ryberg, M, Soubeyran, P, and Wedding, U

Abstract

BACKGROUND: Comorbidities and risk factors likely to complicate treatment are common in elderly cancer patients. Anthracyclines remain the cornerstone of first-line therapy for non-Hodgkin's lymphoma (NHL) and metastatic and early breast cancer but can cause congestive heart failure. Elderly patients are at increased risk of this event and measures to reduce it should be considered. METHODS: A committee of experts in breast cancer and NHL met under the auspices of the International Society for Geriatric Oncology to review the literature and make recommendations, based on level of evidence, for the assessment, treatment and monitoring of elderly patients requiring anthracyclines. Results and recommendations: Use of anthracycline-based chemotherapy illustrates many of the dilemmas facing elderly cancer patients. Age in itself should not prevent access to potentially curative treatment or treatment that prolongs life or improves its quality. The risk of cardiotoxicity with conventional anthracyclines is increased by the following factors: an existing or history of heart failure or cardiac dysfunction; hypertension, diabetes and coronary artery disease; older age (independent of comorbidities and performance status); prior treatment with anthracyclines; higher cumulative dose of anthracyclines and short infusion duration. The fact that cumulative and irreversible cardiotoxicity is likely to be greater in this population than among younger patients calls for effective pretreatment screening for risk factors, rigorous monitoring of cardiac function and early intervention. Use of liposomal anthracycline formulations, prolonging the infusion time for conventional anthracyclines and cardioprotective measures should be considered. However, when treatment is being given with curative intent, care should be taken to ensure reduced cardiotoxicity is not achieved at the expense of efficacy.

Published
2011

53. Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation.

Author

Johannsson, G, Nilsson, A G, Bergthorsdottir, R, Burman, Pia, Dahlqvist, P, Ekman, B, Engström, B E, Olsson, T, Ragnarsson, O, Ryberg, M, Wahlberg, J, Biller, B M K, Monson, J P, Stewart, P M, Lennernäs, H, Skrtic, S, Johannsson, G, Nilsson, A G, Bergthorsdottir, R, Burman, Pia, Dahlqvist, P, Ekman, B, Engström, B E, Olsson, T, Ragnarsson, O, Ryberg, M, Wahlberg, J, Biller, B M K, Monson, J P, Stewart, P M, Lennernäs, H, and Skrtic, S

Abstract

Context:Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective:The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of conventional hydrocortisone tablets.Design and Setting:We conducted an open, randomized, two-period, 12-wk crossover multicenter trial with a 24-wk extension at five university hospital centers.Patients:The trial enrolled 64 adults with primary AI; 11 had concomitant diabetes mellitus (DM).Intervention:The same daily dose of hydrocortisone was administered as OD dual-release or TID.Main Outcome Measure:We evaluated cortisol pharmacokinetics.Results:Compared with conventional TID, OD provided a sustained serum cortisol profile 0-4 h after the morning intake and reduced the late afternoon and the 24-h cortisol exposure. The mean weight (difference = -0.7 kg, P = 0.005), systolic blood pressure (difference = -5.5 mm Hg, P = 0.0001) and diastolic blood pressure (difference: -2.3 mm Hg; P = 0.03), and glycated hemoglobin (absolute difference = -0.1%, P = 0.0006) were all reduced after OD compared with TID at 12 wk. Compared with TID, a reduction in glycated hemoglobin by 0.6% was observed in patients with concomitant DM during OD (P = 0.004).Conclusion:The OD dual-release tablet provided a more circadian-based serum cortisol profile. Reduced body weight, reduced blood pressure, and improved glucose metabolism were observed during OD treatment. In particular, glucose metabolism improved in patients with concomitant DM.

Published
2011

54. Improved Quality of Life in Patients with Primary Adrenal Insufficiency by Using a Novel Once-Daily Dual Release Hydrocortisone Tablet: A Randomised Controlled, Cross-Over Trial. in ENDOCRINE REVIEWS, vol 31, issue 3, pp

Author

Johannsson, G, Nilsson, A G, Bergthorsdottir, R, Burman, P A, Eden Engstrom, B, Ekman, Bertil, Dahlqvist, P, Ryberg, M, Ragnarsson, O, Wahlberg Topp, Jeanette, Lennernas, H, Skrtic, S, Johannsson, G, Nilsson, A G, Bergthorsdottir, R, Burman, P A, Eden Engstrom, B, Ekman, Bertil, Dahlqvist, P, Ryberg, M, Ragnarsson, O, Wahlberg Topp, Jeanette, Lennernas, H, and Skrtic, S

Abstract

n/a

Published
2010

60. The association of bacterial adhesion with dental caries.

Author

Stenudd, C, Nordlund, Åke, Ryberg, M, Johansson, Ingegerd, Källestål, Carina, Strömberg, Nicklas, Stenudd, C, Nordlund, Åke, Ryberg, M, Johansson, Ingegerd, Källestål, Carina, and Strömberg, Nicklas

Abstract

Saliva adhesion of bacteria is a key event in oral biofilm formation. Here, we used partial least-squares (PLS) analysis to correlate adhesion of cariogenic (Streptococcus mutans Ingbritt) and commensal (Actinomyces naeslundii LY7) model bacteria, and their agglutinin and acidic proline-rich protein ligands, respectively, with high and low caries experiences in 38 children reflecting today's skewed caries distribution. Adhesion of S. mutans was among the factors correlating strongest with high caries experience when PLS modeled together with traditional factors (e.g., sugar intake, lactobacilli counts). Saliva phenotypes with high agglutinin levels and Db-s (an acidic PRP variant) coincided with both high caries experience and S. mutans adhesion. A. naeslundii adhesion correlated with low caries experience. Non-Db phenotypes (i.e., acidic PRP-1 and PRP-2 variants) coincided with both low caries experience and S. mutans, but high A. naeslundii, adhesion. Thus, bacterial adhesion may modulate susceptibility and resistance to dental caries.

Published
2001

62. Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal streptococcus and actinomyces species.

Author

Li, T, Bratt, P, Jonsson, AP, Ryberg, M, Johansson, Ingegerd, Griffiths, WJ, Bergman, T, Strömberg, Nicklas, Li, T, Bratt, P, Jonsson, AP, Ryberg, M, Johansson, Ingegerd, Griffiths, WJ, Bergman, T, and Strömberg, Nicklas

Abstract

This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr(1)-Pro(104)Pro(105) and a Gly(111)-Pro(149)Gln(150) peptide together with a presumed Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) pentapeptide. The synthetic Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.

Published
2000

69. Anti-adhesion and diagnostic strategies for oro-intestinal bacterial pathogens.

Author

Strömberg, Nicklas, Ahlfors, S, Borén, Thomas, Bratt, P, Hallberg, K, Hammarström, KJ, Holm, C, Johansson, Ingegerd, Järvholm, M, Kihlberg, J, Li, T, Ryberg, M, Zand, G, Strömberg, Nicklas, Ahlfors, S, Borén, Thomas, Bratt, P, Hallberg, K, Hammarström, KJ, Holm, C, Johansson, Ingegerd, Järvholm, M, Kihlberg, J, Li, T, Ryberg, M, and Zand, G

Published
1996

71. The effects of long-term treatment with salmeterol and salbutamol on the flow rate and composition of whole saliva in the rat.

Author

Ryberg, M, Johansson, Ingegerd, Ryberg, M, and Johansson, Ingegerd

Abstract

The effect of long-acting beta 2-adrenoceptor agonists on salivary glands and saliva secretion has not been studied before. Sprague-Dawley rats were given either the long-acting beta 2-agonist salmeterol, 1 mg/kg body wt per day or the short-acting agonist salbutamol, 5 mg/kg per day. Saline solution was used as control. After 18 days pilocarpine-stimulated saliva was collected, and after 21 days saliva was collected after stimulation with isoproterol and pilocarpine in combination. The saliva was analysed for total protein, amylase, hexosamine, sialic acid, sodium, potassium and calcium. At day 25 the salivary glands were extirpated and weighed. The weight of the parotid glands increased significantly after both salmeterol and salbutamol treatment, approx. 40%; the submandibular gland weights were not affected by either beta 2-agonist treatment. Pilocarpine-stimulated salivary flow rate was increased in the salbutamol, but not in the salmeterol, group. In the salmeterol group the concentration of sialic acid was increased and that of calcium was decreased. In saliva stimulated with pilocarpine and isoproterenol in combination, the concentrations of total protein, amylase and calcium were decreased after salmeterol. In the salbutamol group, total protein and potassium were decreased. The ratio sialic acid: total protein was increased at both saliva collections in both beta 2-agonist groups. It is concluded that rats treated chronically with the long-acting beta 2-adrenoceptor agonist salmeterol have an impaired secretion of salivary proteins and calcium and that the effect resembles that of salbutamol.

Published
1995
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82. Effects of chronic stimulation of salivary gland beta-adrenoceptors on saliva composition and caries development in the rat.

Author

Ryberg, M, Johansson, I, Ericson, T, Mörnstad, H, Henriksson, R, Jönsson, G, and Sundström, S

Abstract

The effects of long-term beta-adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development. [ABSTRACT FROM AUTHOR]

Published
1989
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83. Effects of chronic stimulation of salivary gland β-adrenoceptors on saliva composition and caries development in the rat.

Author

Ryberg, M., Johansson, I., Ericson, T., Mörnstad, H., Henriksson, R., Jönsson, G., and Sundström, S.

Subjects
SALIVARY glands, EXOCRINE glands, MOUTH, ADRENERGIC receptors, ISOPROTERENOL, RATS
Abstract

The effects of long-term β-adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development. [ABSTRACT FROM AUTHOR]

Published
1989
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84. Interleukin-1 affects the function of cultured human thyroid cells.

Author

Rasmussen, Å. Krogh, Bech, K., Feldt-Rasmussen, U., Poulsen, S., Holten, I., Ryberg, M., Dinarello, C. A., Siersbæk-Nielsen, K., Friis, T., and Bendtzen, K.

Subjects
ACUTE phase proteins, MONOKINES, ORGANOIODINE compounds, THYROGLOBULIN, THYROID gland blood-vessels, CYTOKINES
Abstract

Cytokines are peptide hormones essential for cellular communication in the immune response. The purpose of this study was to investigate the influence of cytokines, especially recombinant interleukin 1 β (rIL-1β ), on human thyroid cells. Thyroglobulin (Tg) was measured by a double antibody radioimmunoassay, and cyclie AMP (camp) by a competitive protein binding assay, Supernatants from unstimulated and phytohaemagglutinin-stimulated blood mononuclear cells were added to human thyroid cells cultured in monolayers. A dose-dependent inhibition of the secretion of Tg and camp secretion, while at physiological levels (10-1-10-2 U/ml) exhibited an inhibition of Tg and cAMP secretion, while at physiological levels (10-5-10-3 U/ml), the secretion of Tg was enhanced. The similar stimulation of camp was demonstrated in subcultures. These in vitro studies suggest that IL-1β may play a role in the pathogenesis of autoimmune thyroid diseases. Further, the stimulations at low concentrations indicate that IL-1β may regulate the function of the thyroid gland under physiological conditions. [ABSTRACT FROM AUTHOR]

Published
1988
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87. Light-induced changes in the distribution of the 36000-Mr polypeptide of NADPH-protochlorophyllide oxidoreductase within different cellular compartments of barley (Hordeum vulgare L.)

Author

Dehesh, K., Cleve, B., Ryberg, M., and Apel, K.

Abstract

The cellular distribution of the 36000-Mr polypeptide of NADPH-protochlorophyllide oxidoreductase has been determined in ultrathin sections of barley leaves by the method of immunogold labelling. In leaves of etiolated seedlings a large portion of the immunoreactive protein was localized within the prolamellar body. However, approximately one third of the total immunoreactive protein was present outside the plastid in the area of the plasmalemma. During illumination of etiolated seedlings the two polypeptide populations were differentially affected by light. While the concentration of the plastid-localized immunoreactive protein rapidly decreased and was hardly detectable after 16 h of continuous white-light treatment, the concentration of the extraplastidic polypeptide did not decline significantly during this illumination period. A similar distribution pattern of the immunoreactive polypeptide was also found in maize and rye. The chlorophyll-deficient barley mutant xantha-l81 contained the immunoreactive 36000-Mr polypeptide, even though the prolamellar body was not detectable in etioplasts of this mutant. All of the immunoreactive polypeptide was localized outside the plastid in the area of the plasmalemma. Despite the apparent absence of the enzyme protein from the plastid, dark-grown mutant plants contained the same relative concentration of mRNA activity for the NADPH-protochlorophyllide oxidoreductase, which declined rapidly during illumination, as in wild-type plants. The antigenic properties and the apparent molecular weight of the plastid-localized NADPH-protochlorophyllide oxidoreductase and the 36000-Mr immunoreactive polypeptide outside the plastid were so similar as to indicate that the two proteins may be of common origin.

Published
1986
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90. Effect of β2-Adrenoceptor Agonists on Saliva Proteins and Dental Caries in Asthmatic Children.

Author

RYBERG, M., MÖLLER, C., and ERICSON, T.

Subjects
BETA adrenoceptors, SALIVARY proteins, DENTAL caries, ASTHMA in children, ASTHMATICS, ORAL hygiene
Abstract

Twenty-four children, from 10 to 20 years old, with asthma treated with β2-adrenoceptor agonists were matched with healthy controls of the same age, sex, and social background. Stimulated whole and parotid saliva was collected, and decayed and filled tooth surfaces as well as oral hygiene habits were recorded. The dietary and sugar intake was carefully checked by a four-day dietary record. The asthmatic children had a 26% lower (p<0.05) value for secretion rate of whole saliva. Seventy percent of the children with Streptococcus mutans counts >2x105 colony-forming units/mL of whole saliva belonged to the asthmatic group (p<0.05). The concentrations of total protein and amylase in parotid saliva were significantly lower for the asthmatic children. The concentrations of potassium, salivary peroxidase, bacteria-aggregating glycoproteins, and secretary IgA were not affected, but the secretion rate of parotid saliva was 36% lower in the asthma group (p<0.05). Oral hygiene and dietary habits did not differ between the groups. The asthmatic children had higher DFS scores, but these were not significantly different from those of the healthy controls (p = 0.07). We suggest that subjects with asthma treated with β 2-receptor agonists should receive special prophylactic attention. [ABSTRACT FROM AUTHOR]

Published
1987
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94. The Assessment of Urban Environmental Impacts through the City Environmental Footprint: Methodological Framework and First Approach to the Built Environment

Author

Nadia Mirabella, Karen Allacker, Laurent, A, Leclerc, A, Niero, M, Dong, Y, Olsen, SI, Owsianiak, M, Bey, N, Ryberg, M, and Hauschild, MZ

Subjects
Sustainable development, Ecological footprint, 0211 other engineering and technologies, Psychological intervention, 021107 urban & regional planning, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Urbanization, Sustainability, General Earth and Planetary Sciences, Environmental impact assessment, Business, Environmental planning, Built environment, Stock (geology), 0105 earth and related environmental sciences, General Environmental Science
Abstract

© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. In 2015, the United Nations chose cities as target of the 11th Sustainable Development Goals, which aim to "make cities inclusive, safe, resilient, and sustainable". Indeed, the increasing urbanization worldwide poses serious threats for the related environmental burdens, but also opportunities for cities to be a driver for change and privileged places for interventions in favor of sustainability. In order to achieve such ambitious targets, holistic methodologies are necessary but lacking to date. The main objectives of this paper are: i) providing strong and working points of current quantitative methods available for environmental assessment and insights in the methodological challenges; ii) presenting the concept of a new methodological approach, the City Environmental Footprint (City EF), as proposal for a comprehensive urban environmental assessment; iii) preparatory approach of City EF to the urban building stock in Leuven (Belgium). ispartof: pages:83-88 ispartof: Procedia CIRP vol:69 pages:83-88 ispartof: 25th CIRP Life Cycle Engineering (LCE) Conference location:Copenhagen date:30 Apr - 2 May 2018 status: published

Published
2018

95. Taking Evolution into Account in a Parametric LCA Model for PV Panels

Author

Ellen Bracquené, Jef R. Peeters, Joost Duflou, Wim Dewulf, Laurent, A, Leclerc, A, Niero, M, Dong, Y, Olsen, SI, Owsianiak, M, Bey, N, Ryberg, M, and Hauschild, MZ

Subjects
Dematerialization (products), Scope (project management), business.industry, Computer science, 020209 energy, Photovoltaic system, 02 engineering and technology, Environmental economics, Renewable energy, 0202 electrical engineering, electronic engineering, information engineering, General Earth and Planetary Sciences, Production (economics), Environmental impact assessment, business, Life-cycle assessment, General Environmental Science, Parametric statistics
Abstract

© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. Over the last decade the environmental impact of photovoltaic (PV) panels has extensively been explored, often using a Life Cycle Assessment (LCA) methodology. However, the manufacturing data in reference databases are typically outdated and the end-of-life treatment is mostly omitted from the scope of these studies. The objective of the current study is to inform decision-makers about potential environmental impact reductions, mostly through dematerialization of the manufacturing phase and secondary material recovery at end-of-life. The results show how taking into account eco-design aspects in the manufacturing stage and a well-designed end-of-life treatment system can further contribute to lowering the environmental impact of PV panels and thus renewable energy production. ispartof: pages:389-394 ispartof: 25TH CIRP LIFE CYCLE ENGINEERING (LCE) CONFERENCE vol:69 pages:389-394 ispartof: 25th CIRP Life Cycle Engineering (LCE) Conference. location:Copenhagen date:30 Apr - 2 May 2018 status: Published online

Published
2018

96. Framework to combine technical, economic and environmental points of view of additive manufacturing processes

Author

Olivier Kerbrat, Pascal Mognol, Mazyar Yosofi, Laboratoire de Génie Civil et Génie Mécanique (LGCGM), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), French Brittany region, EcoSD network, Laurent, A, Leclerc, A, Niero, M, Dong, Y, Olsen, SI, Owsianiak, M, Bey, N, Ryberg, M, Hauschild, MZ, Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Rennes (ENS Rennes), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)

Subjects
0209 industrial biotechnology, Environmental analysis, Computer science, Manufacturing process, Additive manufacturing, Production cost, Mechanical properties, 02 engineering and technology, 021001 nanoscience & nanotechnology, Manufacturing engineering, [SPI.MECA.GEME]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph], Product (business), Environmental impact, 020901 industrial engineering & automation, General Earth and Planetary Sciences, Production (economics), Environmental impact assessment, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, 0210 nano-technology, General Environmental Science
Abstract

International audience; Additive manufacturing is an innovative way to produce complex parts. Nowadays, knowledge about mechanical properties and production costs are well known. Many studies found in the literature present comparisons between different additive manufacturing technologies based on technical or economical criterions. However, the environmental analysis of the phenomena that occur during the manufacturing step is still limited. To ensure the development of these processes it seems important to get predictive models of the environmental impacts, allowing to evaluate the product from a technical, economic and environmental point of view. This paper presents a new methodology for the environmental impact evaluation, combined with a technical and economical assessment. This methodology is applied on multiple additive manufacturing processes and will help manufacturers like a decision-making tool to make a choice of manufacturing process based on multiple criterion.

Published
2018

97. Maintenance optimization: Application of remanufacturing and repair strategies

Author

James Mutuota Wakiru, Peter Muchiri, Liliane Pintelon, Peter Chemweno, Laurent, A, Leclerc, A, Niero, M, Dong, Y, Olsen, SI, Owsianiak, M, Bey, N, Ryberg, M, and Hauschild, MZ

Subjects
0209 industrial biotechnology, Mean time to recovery, Power station, Computer science, 02 engineering and technology, 010501 environmental sciences, Reuse, 01 natural sciences, Reliability engineering, 020901 industrial engineering & automation, Electricity generation, General Earth and Planetary Sciences, Production (economics), Discrete event simulation, Remanufacturing, Lead time, 0105 earth and related environmental sciences, General Environmental Science
Abstract

Power plant facilities located in remote and difficult to access regions often experience significant production losses due to failures, inaccurate remanufacturing, maintenance activities in addition to prolonged lead time delays while procuring critical spares. This is especially the case given unanticipated power plant failures which could portend significant power generation losses besides outages that could lead to significant societal disruptions, for instance, off grid hospital facilities. This study uses a discrete event simulation model to analyze the effect of remanufacturing and maintenance as part of circular economy strategies, on power plant availability and maintenance time. The proposed study is demonstrated through the use case of a thermal power plant located in a remote region, where findings suggest replacing components upon failure has the most significant impact and effect on system availability as well as maintenance time. Moreover, a reduction of mean time before Overhaul (MTBO) seems to lengthen the component's usage-life, hence reduces the maintenance time, and at the same time, increases the system availability. Reuse activity also yields a better mean time to recovery (MTTR), while repair has the highest amongst the evaluated recovery strategies. The study adds value by developing a framework, further applying a simulation modelling approach for evaluating the effects of remanufacturing and maintenance strategies on plant availability. ispartof: pages:899-904 ispartof: Procedia CIRP vol:69 pages:899-904 ispartof: 25th CIRP Life Cycle Engineering (LCE) Conference location:Copenhagen, Denmark date:30 Apr - 2 May 2018 status: Published online

Published
2018

98. The evolution of ectomycorrhizal symbiosis and host-plant switches are the main drivers for diversification of Amanitaceae (Agaricales, Basidiomycota).

Author

Cai Q, Codjia JEI, Buyck B, Cui YY, Ryberg M, Yorou NS, and Yang ZL

Subjects
Agaricales genetics, Agaricales physiology, Biodiversity, Mycorrhizae physiology, Mycorrhizae genetics, Symbiosis, Biological Evolution, Phylogeny
Abstract

Background: Evolutionary radiation is widely recognized as a mode of species diversification, but the drivers of the rapid diversification of fungi remain largely unknown. Here, we used Amanitaceae, one of the most diverse families of macro-fungi, to investigate the mechanism underlying its diversification., Results: The ancestral state of the nutritional modes was assessed based on phylogenies obtained from fragments of 36 single-copy genes and stable isotope analyses of carbon and nitrogen. Moreover, a number of time-, trait-, and paleotemperature-dependent models were employed to investigate if the acquisition of ectomycorrhizal (ECM) symbiosis and climate changes promoted the diversification of Amanitaceae. The results indicate that the evolution of ECM symbiosis has a single evolutionary origin in Amanitaceae. The earliest increase in diversification coincided with the acquisition of the ECM symbiosis with angiosperms in the middle Cretaceous. The recent explosive diversification was primarily triggered by the host-plant switches from angiosperms to the mixed forests dominated by Fagaceae, Salicaceae, and Pinaceae or to Pinaceae., Conclusions: Our study provides a good example of integrating phylogeny, nutritional mode evolution, and ecological analyses for deciphering the mechanisms underlying fungal evolutionary diversification. This study also provides new insights into how the transition to ECM symbiosis has driven the diversification of fungi., (© 2024. The Author(s).)

Published
2024
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99. High rate of gene family evolution in proximity to the origin of ectomycorrhizal symbiosis in Inocybaceae.

Author

Khan FK, Sánchez-García M, Johannesson H, and Ryberg M

Subjects
Genes, Fungal, Genome, Fungal, DNA Transposable Elements genetics, Agaricales genetics, Agaricales physiology, Mycorrhizae physiology, Mycorrhizae genetics, Symbiosis genetics, Evolution, Molecular, Phylogeny, Multigene Family
Abstract

The genomes of ectomycorrhizal (ECM) fungi have a reduced number of genes encoding Carbohydrate-Active EnZymes (CAZymes), expansions in transposable elements (TEs) and small secreted proteins (SSPs) compared with saprotrophs. Fewer genes for specific peptidases and lipases in ECM fungi are also reported. It is unclear whether these changes occur at the shift to the ECM habit or are more gradual throughout the evolution of ECM lineages. We generated a genomic dataset of 20 species in the ECM lineage Inocybaceae and compared them with six saprotrophic species. Inocybaceae genomes have fewer CAZymes, peptidases, lipases, secondary metabolite clusters and SSPs and higher TE content than their saprotrophic relatives. There was an increase in the rate of gene family evolution along the branch with the transition to the ECM lifestyle. This branch had very high rate of evolution in CAZymes and had the largest number of contractions. Other significant changes along this branch included expansions in transporters, transposons-related genes and communication genes such as fungal kinases. There is a high concentration of changes in proximity to the transition to the ECM lifestyle, which correspond to the identified key changes for the gain of this lifestyle., (© 2024 The Author(s). New Phytologist © 2024 New Phytologist Foundation.)

Published
2024
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100. Critical illness survivors' experiences of attending an intensive care unit follow-up service: a systematic review protocol.

Author

Delaney S, Cook JE, Ryberg M, O'Donnell S, and Byrne G

Subjects
Adult, Humans, Follow-Up Studies, Systematic Reviews as Topic, Survivors psychology, Review Literature as Topic, Critical Illness therapy, Intensive Care Units
Abstract

Objective: The objective of this review is to explore critical illness survivors' experiences of attending an intensive care unit (ICU) follow-up service., Introduction: A significant proportion of critical illness survivors will require ICU follow-up care to support adverse symptoms in health domains, including cognition, mental health, and physical and social function. While there is consensus on the need for ICU follow-up services, systematic reviews to date have not identified any significant impact of ICU follow-up services on clinical health outcomes. An understanding of survivors' experiences of attending an ICU follow-up service may improve the effectiveness and design of such services., Inclusion Criteria: This review will include studies that explore the experiences of adult ( 18 years of age) critical illness survivors who attended an ICU follow-up service following discharge from an ICU, regardless of the admitting diagnosis or ICU length of stay., Methods: This review will be conducted in line with the JBI methodological framework for qualitative systematic reviews. Electronic databases, including MEDLINE, CINAHL, PsycINFO, Embase, and Web of Science Core Collection, will be searched to identify relevant studies for inclusion in the review. Studies will be screened by 2 independent reviewers. Critical appraisal, data extraction, and data synthesis will be completed by 2 independent reviewers using a meta-aggregation method for data synthesis. Confidence in the research findings will be assessed and assigned a ConQual score., Review Registration: PROSPERO CRD42023404585., Competing Interests: The authors declare no conflict of interest., (Copyright © 2023 JBI.)

Published
2023
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