94 results on '"Rosana, Lazzarini"'
Search Results
52. Evaluation of nickel and cobalt release from mobile phone devices used in Brazil
- Author
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Jessica Chia Sin Chen, Rosana Lazzarini, and Mariana de Figueiredo Silva Hafner
- Subjects
inorganic chemicals ,medicine.medical_specialty ,Allergy ,Cell phones ,chemistry.chemical_element ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Nickel ,otorhinolaryngologic diseases ,Humans ,Medicine ,Allergic contact dermatitis ,business.industry ,Communication ,Cobalt ,General Medicine ,Patch Tests ,medicine.disease ,030228 respiratory system ,chemistry ,Mobile phone ,RL1-803 ,Dermatitis, Allergic Contact ,business ,Brazil ,Cell Phone - Abstract
Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. We evaluated devices of 6 brands and 20 different models using nickel and cobalt allergy spot tests. Of the 20 models, 64.7% tested positive for nickel, with 41.1% positive results for the charger input and 23.5% for other tested areas. None of them was positive for cobalt. Nickel release was more common in older models.
- Published
- 2018
53. Pretibial dystrophic epidermolysis bullosa
- Author
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Flavio Nappi, Rosana Lazzarini, Rute Facchini Lellis, and Elisabeth de Albuquerque Cavalcanti Callegaro
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Epidermolysis bullosa dystrophica ,Pathology ,medicine.medical_specialty ,Case Report ,Dermatology ,Biology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Anchoring fibrils ,medicine ,COL7A1 Gene ,skin and connective tissue diseases ,Gene ,Collagen type VII ,integumentary system ,General Medicine ,medicine.disease ,Milia ,RL1-803 ,030220 oncology & carcinogenesis ,Immunohistochemistry ,Epidermolysis bullosa ,Differential diagnosis ,Lichen planus - Abstract
Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main constituent of anchoring fibrils. In this group, there are autosomal dominant and recessive inheritances. The pre-tibial form is characterized by the presence of blisters, milia, atrophic scars and lesions similar to lichen planus. The diagnosis is clinical and laboratory and subtypes are distinguished by means of immunohistochemical and ultrastructural studies, in addition to genetic differentiation. Electron microscopy and immunomapping are used in the diagnosis.
- Published
- 2017
54. Doação
- Author
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Rosana Lazzarini
- Subjects
Dermatology ,RL1-803 - Published
- 2006
- Full Text
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55. Nickel exposure from keys: a Brazilian issue
- Author
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Mariana de Figueiredo Silva Hafner, Nathalie Mie Suzuki, Ida Duarte, and Rosana Lazzarini
- Subjects
inorganic chemicals ,Positive reaction ,chemistry.chemical_element ,Dermatology ,Toxicology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Nickel ,otorhinolaryngologic diseases ,Humans ,Household Articles ,Communication ,Environmental Exposure ,Cobalt ,Patch Tests ,Dermatitis, allergic contact ,chemistry ,Consumer Product Safety ,Metals ,030220 oncology & carcinogenesis ,RL1-803 ,Business ,Brazil - Abstract
Keys are a significant source of exposure to metal allergens and can be a relevant problem for nickel-allergic individuals. This study aimed to perform nickel and cobalt spot testing among the 5 most common Brazilian brands of keys. Among the tested keys, 100% showed positive result to nickel spot test, 83,3% presented strong positive reaction. 50% exhibited cobalt release as well. Nickel release from keys is very common in our country and may cause a negative impact on sensitized individual's quality of life. Study's results highlight the importance of establishing directives to regulate nickel release in Brazil.
- Published
- 2017
56. Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests
- Author
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Barbara A. F. Miguel, Beatriz Harumi Yuda Nakagome, Rosana Lazzarini, Mariana de Figueiredo Silva Hafner, and Nathalia Terumi Kawakami
- Subjects
Male ,medicine.medical_specialty ,Antifungal Agents ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Immunology and Allergy ,Humans ,030212 general & internal medicine ,Allergic contact dermatitis ,Retrospective Studies ,business.industry ,Dermatitis, Photoallergic ,Topical ketoconazole ,Patch test ,Middle Aged ,Patch Tests ,medicine.disease ,Ketoconazole ,Dermatitis, Allergic Contact ,Female ,Drug Eruptions ,business ,medicine.drug - Published
- 2017
57. Evaluation of the presence of allergens in children's products available for sale in a big city
- Author
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Rosana Lazzarini, Mariana de Figueiredo Silva Hafner, and Mayara Gomes Rangel
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medicine.medical_specialty ,media_common.quotation_subject ,Population ,Dermatology ,Cosmetics ,medicine.disease_cause ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,medicine ,Humans ,030212 general & internal medicine ,Product (category theory) ,education ,Child ,Allergic contact dermatitis ,Additives in cosmetics ,media_common ,Skin Tests ,education.field_of_study ,Dermatitis, contact ,Hypoallergenic ,General Medicine ,Allergens ,medicine.disease ,Dermatitis, allergic contact ,Available for sale ,Food ,RL1-803 ,Dermatitis, Allergic Contact ,Business ,Haptens ,Contact dermatitis ,Brazil - Abstract
Children's products are considered safe by the general population and doctors. Labels with terms such as "hypoallergenic" or "dermatologically recommended and tested" denote trust and credibility with the idea that they can be used by any individual. Patients with allergic contact dermatitis may be sensitive to allergens present in any product, including children's. There is insufficient knowledge about allergens in these products in our country. We evaluated 254 children's products, and at least one allergen was present in 236 (93%) of them. The indication of a topical product should be careful and based on contact tests.
- Published
- 2017
58. Eczemas
- Author
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Rosana Lazzarini, Mariana de Figueiredo Silva Hafner, Vanessa Barreto Rocha, and Daniel Lorenzini
- Published
- 2017
59. Nickel, chromium and cobalt: the relevant allergens in allergic contact dermatitis. Comparative study between two periods: 1995-2002 and 2003-2015
- Author
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Ida Duarte, Rosana Lazzarini, Mariana de Figueiredo Silva Hafner, Rodolfo Ferreira Mendonça, and Karen Levy Korkes
- Subjects
Chromium ,Male ,Time Factors ,010501 environmental sciences ,01 natural sciences ,Gastroenterology ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Nickel ,Epidemiology ,Child ,Sensitization ,Not evaluated ,Aged, 80 and over ,education.field_of_study ,Incidence (epidemiology) ,General Medicine ,Cobalt ,Middle Aged ,Dermatitis, allergic contact ,medicine.anatomical_structure ,Dermatitis, Occupational ,Metals ,RL1-803 ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,chemistry.chemical_element ,Dermatology ,Patch tests ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,education ,Allergic contact dermatitis ,0105 earth and related environmental sciences ,Aged ,Retrospective Studies ,Investigation ,business.industry ,Dermatitis, contact ,Allergens ,medicine.disease ,chemistry ,Immunization ,business ,Skin tests - Abstract
Background: Metals are common agents of allergic contact dermatitis, occupational or not, with decreasing incidence over the last years in some countries that have regulated the amount of nickel in objects. Objectives: To analyze and compare with previous studies the profile of metal sensitization between 2003-2015. Methods: Patients who underwent patch testing between 2003-2015 were evaluated retrospectively regarding the sensitization rates to metals, the associations between them, the relationship with profession and epidemiology. Results: Of the 1,386 patients tested, 438 (32%) had positive test to some metal, similar results to the 404/1,208 (33%) of the previous study (1995-2002) performed at the same service (p=0.32). The frequency of nickel (77%), cobalt (32%) and chromium (29%) changed slightly (p=0.20). Most cases of sensitization to chromium were related to the occupation (64%), in contrast to nickel and cobalt (p
- Published
- 2016
60. Allergic contact dermatitis among construction workers detected in a clinic that did not specialize in occupational dermatitis
- Author
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Ida Duarte, Rogério Sgura Minnicelli, Juliana Mayumi Sumita, and Rosana Lazzarini
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Adult ,Male ,Gynecology ,medicine.medical_specialty ,Occupational Dermatitis ,Construction Materials ,business.industry ,Construction Industry ,Potassium dichromate ,Dermatology ,Middle Aged ,medicine.disease ,Dermatitis, allergic contact ,Dermatitis, Occupational ,Dermatitis, Allergic Contact ,Occupational diseases ,medicine ,Humans ,Rubber ,Gloves, Protective ,business ,Allergic contact dermatitis ,Retrospective Studies - Abstract
FUNDAMENTOS: A dermatite de contato e uma das dermatoses comumente relacionadas ao trabalho. Entre os pedreiros o cimento pode causar tanto a Dermatite Alergica de Contato quanto a Dermatite de Contato por Irritacao Primaria. Os equipamentos de protecao individual (luvas de borracha) podem favorecer o desenvolvimento de Dermatite Alergica de Contato. OBJETIVOS: 1) avaliar a frequencia de Dermatite Alergica de Contato entre os pedreiros entre Janeiro de 2005 e Dezembro de 2009; 2) determinar os principais agentes sensibilizantes; e 3) comparar os resultados obtidos entre o grupo de pedreiros com um grupo sem pedreiros. METODOS: analise retrospectiva de testes de contato. Pacientes foram separados em 2 grupos: 1) pedreiros e 2) nao pedreiros. RESULTADOS: dentre os 525 testes de contato analisados, 466 (90%) eram de nao pedreiros e 53 (10%) de pedreiros. As maos foram acometidas em 38 (61%). 13 pacientes (24%) tinham Dermatite de Contato por Irritacao Primaria e 40 (76%) tinham Dermatite Alergica de Contato. O grupo de pedreiros apresentou alta frequencia de sensibilizacao ao cimento, e 29 (54,7%) tinham sensibilizacao a agentes vulcanizadores da borracha. 23 pacientes (43,4%) pedreiros tinham sensibilizacao tanto ao cimento quanto a borracha. CONCLUSOES: entre os pedreiros a presenca de Dermatite Alergica de Contato ao cimento e a borracha no mesmo paciente foi comum e demonstrou a importância do teste de contato.
- Published
- 2012
61. Reflectance confocal microscopy of tinea nigra: comparing images with dermoscopy and mycological examination results
- Author
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Ricardo Bertozzi de Avila, Rosana Lazzarini, John Verrinder Veasey, and Marcus Antônio Maia de Olivas Ferreira
- Subjects
Reflectance confocal microscopy ,Culture media ,Pathology ,medicine.medical_specialty ,Culture ,Bacterial infections and mycoses ,Dermoscopy ,Dermatology ,Cellular level ,Superficial mycosis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Tinea ,Medicine ,Tinea nigra ,business.industry ,Images in Tropical Dermatology ,Microscopy, confocal ,medicine.disease ,Skin diseases ,Phaeohyphomycosis ,Mycoses ,030220 oncology & carcinogenesis ,RL1-803 ,business ,Infectious agent - Abstract
Tinea nigra is a superficial mycosis whose diagnosis is confirmed by isolating the infectious agent Hortae werneckii through mycological examinations. In vivo reflectance confocal microscopy, initially used in melanocytic dermatosis, has been used with skin infectious diseases to identify the parasite at the cellular level. We report, for the first time in the scientific literature, the use of reflectance confocal microscopy in a case of tinea nigra and compare its findings to dermoscopy and mycological examination results.
- Published
- 2017
62. Allergy to hypoallergenic nail polish: does this exist?
- Author
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Mariana de Figueiredo Silva Hafner, Andressa Sato de Aquino Lopes, Rosana Lazzarini, and Camilla Bilac Oliari
- Subjects
Products for nails and cuticles ,Allergy ,medicine.medical_specialty ,Allergic reaction ,Cosmetics ,Dermatology ,medicine.disease_cause ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,medicine ,Humans ,business.industry ,Communication ,Contact dermatitis ,Patch test ,Hypoallergenic ,medicine.disease ,humanities ,eye diseases ,Nail polish ,Dermatitis, allergic contact ,medicine.anatomical_structure ,RL1-803 ,030220 oncology & carcinogenesis ,Nail (anatomy) ,business - Abstract
The main allergen responsible for contact dermatitis to nail polish is tosylamide-formaldehyde resin. The so-called hypoallergenic nail polishes are suposedly free of agents that commonly trigger reactions. The commercially available products and their compositions were studied. It was observed that most brands present at least one component capable of triggering the disease; therefore, allergic reaction may occur even when hypoallergenic polishes are used. There should be a proper investigation of the specific allergen through a patch test, because more than one component can cause an allergy, and we need to check the exact composition of each product.
- Published
- 2017
63. Granuloma actínico de O'Brien: apresentação clínica exuberante
- Author
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Débora Cadore de Farias, Helena Muller, Rosana Lazzarini, and Anita Rotter
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Pathology ,medicine.medical_specialty ,Granuloma ,business.industry ,Erythematous papule ,Dermatology ,medicine.disease ,Giant cells ,Células gigantes ,Granuloma de células gigantes ,Acitretina ,medicine.anatomical_structure ,Actinic granuloma ,Forehead ,medicine ,Histopathology ,giant cell ,Presentation (obstetrics) ,business ,Granuloma annulare - Abstract
O granuloma actínico de O'Brien é uma doença cutânea rara. Há muitas controvérsias na sua caracterização, podendo representar uma entidade nosológica distinta ou uma forma de granuloma anular em áreas expostas. A patogênese é desconhecida; no entanto, acredita-se que a radiação solar seja um fator desencadeante. Os autores relatam o caso de um paciente de 78 anos, branco, que apre sentava há 10 anos pápulas eritematosas e infiltradas na fronte e hemiface à esquerda. O diagnóstico de granuloma actínico de O'Brien foi estabelecido a partir do exame histopatológico, uma vez que o quadro clínico exuberante apresentado pelo paciente diferia do de casos anteriormente observados. O'Brien's actinic granuloma is a rare skin disease. Controversy continues over whether it should be considered a specific condition or a form of granuloma annulare located in sun-exposed areas. Its pathogenesis is unknown; however, the most widely accepted hypothesis suggests that solar radiation is the triggering factor. This paper describes the case of a 78-year old, fair-skinned male, who presented with a 10-year history of an infiltrate of annular erythematous papules on his forehead and left malar region. The diagnosis of O'Brien actinic granuloma was established from histopathology, since the clinical condition of the patient was extensive, unlike cases reported in the literature.
- Published
- 2011
64. Alopecia universalis during treatment with leflunomide and adalimumab - Case report
- Author
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Gabriela Cunha Capareli, Roberta Buense, Rosana Lazzarini, and Rute Facchini Lellis
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musculoskeletal diseases ,medicine.medical_specialty ,Arthritis ,Alopecia areata ,Dermoscopy ,Case Report ,Dermatology ,Antibodies, Monoclonal, Humanized ,Arthritis, Rheumatoid ,medicine ,Adalimumab ,Humans ,Biological therapy ,Rheumatoid arthritis ,skin and connective tissue diseases ,Leflunomide ,Aged ,Skin ,integumentary system ,business.industry ,Tumor Necrosis Factor-alpha ,Alopecia ,Isoxazoles ,medicine.disease ,stomatognathic diseases ,Alopecia universalis ,Antirheumatic Agents ,RL1-803 ,Monoclonal ,Etiology ,Female ,business ,medicine.drug - Abstract
Alopecia areata is a non-scarring form of alopecia that can be localized or widespread. Its etiology is unknown, but immunological factors are implicated in its pathogenesis. With the more frequent use of anti TNFα biologic drugs, some alopecia areata cases during their use have been described. We report a case of universal alopecia in a patient with rheumatoid arthritis while using adalimumab and leflunomide.
- Published
- 2014
65. Progressive macular hypomelanosis: an epidemiological study and therapeutic response to phototherapy
- Author
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Bianca Ishimoto Della Nina, Ida Duarte, Maria Clara Gordiano, Rosana Lazzarini, and Roberta Buense
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Gynecology ,medicine.medical_specialty ,Transtornos da pigmentação ,Pigmentation disorders ,business.industry ,medicine.medical_treatment ,Treatment outcome ,Fototerapia ,Therapeutics ,Dermatology ,Phototherapy ,Ultraviolet therapy ,Terapêutica ,PUVA therapy ,medicine ,business - Abstract
FUNDAMENTOS: A hipomelanose macular progressiva é uma dermatose comum em diferentes continentes. Sua causa é desconhecida e os tratamentos propostos são pouco eficazes. OBJETIVOS: Determinar aspectos epidemiológicos da hipomelanose macular progressiva em pacientes atendidos num setor de fototerapia, no período de 1997 a 2008, e avaliar a resposta terapêutica com PUVA ou UVBNB. MÉTODOS: Foram avaliados 84 pacientes com Hipomelanose Macular Progressiva. Após 16 sessões de fototerapia, a resposta terapêutica foi definida: I=inalterado, MD=melhora discreta(< 50% de repigmentação), MM=melhora moderada(50-79%), MI=melhora intensa(80-99%) e C=cura(100%). Após um tempo mínimo de três meses, pacientes com cura ou MI foram contatados por telefone para avaliar a manutenção do resultado terapêutico. RESULTADOS: Predominaram mulheres (79%) e a cor branca. A idade mínima de aparecimento da Hipomelanose Macular Progressiva foi de 13 anos e a máxima de 36 anos. Fototerapia com PUVA foi indicada em 27 pacientes e UVBNB em 57. Estatisticamente, não houve diferença significante entre o tratamento com PUVA e UVBNB (teste de Fisher P>0.05). A maioria (81%) dos pacientes obteve 50% ou mais de repigmentação e 65% tiveram cura ou MI. Entretanto, 72% apresentaram recorrência das lesões. CONCLUSÃO: A ausência de pacientes, com mais de 40 anos, sugere que a Hipomelanose Macular Progressiva seja uma doença autolimitada. Tanto PUVA como UVB NB são opções terapêuticas, porém não impedem a recidiva da doença. BACKGROUND: Progressive macular hypomelanosis is a common dermatosis in various continents. Its cause is unknown and proposed treatments have had little effect. OBJECTIVES: To determine epidemiological aspects of progressive macular hypomelanosis in patients referred to a phototherapy clinic between 1997 and 2008 and to evaluate therapeutic response to PUVA (psoralen + UVA) photochemotherapy or narrowband UVB phototherapy. METHODS: Eighty-four patients with progressive macular hypomelanosis were evaluated. After 16 phototherapy sessions, therapeutic response was classified as: unchanged, slightly improved (
- Published
- 2010
66. Frequência da dermatite de contato ocupacional em ambulatório de alergia dermatológica
- Author
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Rosana Lazzarini, Ida Duarte, and Anita Rotter
- Subjects
Testes do emplastro ,Dermatitis, contact ,Dermatite de contato ,Dermatology ,Dermatite ocupacional ,Dermatitis, occupational ,Patch tests - Abstract
FUNDAMENTOS: A dermatite de contato ocupacional (DCO) corresponde a 80% dos casos de dermatoses relacionadas ao trabalho. OBJETIVOS: Determinar: a frequência de DCO em pacientes atendidos em ambulatório de alergia, não específico de dermatose ocupacional; o perfil dos pacientes de acordo com idade, sexo, cor, profissão, antecedentes atópicos, duração e localização da dermatose; os tipos de dermatite de contato; os principais alérgenos; e comparar as frequências dos principais sensibilizantes com os resultados obtidos em pacientes atendidos no mesmo período, sem DCO. MÉTODOS: Durante o período 2003-2006, 630 pacientes foram atendidos e submetidos à bateria padrão de testes de contato. Selecionaram-se aqueles com DCO. RESULTADOS: Sessenta e nove (10,9%) pacientes apresentaram DCO. A média de idade foi de 44,5 anos. As mãos foram acometidas em 48 (70%) casos. As profissões prevalentes foram do lar (27,39%) e construção civil (23; 33,5%). Dermatite alérgica de contato (DAC) ocorreu em 48 (70%) casos, e dermatite irritativa de contato (DIC), em 21 (30%). Os principais sensibilizantes foram o bicromato de potássio (28; 41%), sulfato de níquel (16; 23%) e carba-mix (16; 23%). CONCLUSÕES: A DCO foi diagnosticada em 10,9% dos pacientes, sendo mais comum na faixa etária produtiva da população. DAC esteve presente em 48 casos, provavelmente influenciada pelo longo tempo de evolução da dermatose. Os metais e os componentes da borracha foram os principais sensibilizantes. BACKGROUND: Occupational contact dermatitis (OCD) corresponds to 80% of the cases of skin diseases related to work. OBJECTIVES: To determine: the frequency of OCD in an ambulatory of allergy not specific for occupational dermatosis; the profile of these patients according to age, gender, color, profession, atopic history, duration and localization of the dermatosis; the diagnosed types of contact dermatitis; the main allergens and to compare the frequency of the main antigens with the results obtained from patients examined in the same period of time, without DCO. METHODS: During the three-year period from 2003 to 2006, 630 patients were examined and submitted to a battery of standardized contact patch tests and those who were diagnosed with OCD were selected. RESULTS: Sixty-nine out of the 630 patients were diagnosed with OCD. The average age was 44.5 years. Forty-eight patients (70%of the cases) presented the disease on the hands. The most prevalent activities of patients suffering from the disease were household tasks (39%) and building construction (33%). The allergic contact dermatitis (ACD) occurred in 48 cases which represent 70% of the total number of cases and irritant contact dermatitis in 21 cases corresponding to 30% of the total number of cases. The main allergens were potassium dichromate 28 (41%), nickel sulfate 16 (23%) and carba-mix 16 (23%). CONCLUSION: OCD was present in 10.9% of the patients. Concerning age the group in which the disease was more commonly found corresponded to the most productive group of the population. ACD corresponded to 48 cases, probably influenced by the long period of evolution of the dermatosis. Metal and rubber chemicals were the commonest allergens.
- Published
- 2010
67. Qual é o tipo de fototerapia mais comumente indicada no tratamento da psoríase?: UVB banda estreita e PUVA: comportamento da prescrição
- Author
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José Antonio Jabur da Cunha, Rosana Lazzarini, Ida Duarte, and Roberta Buense Bedrikow
- Subjects
medicine.medical_specialty ,Skin type ,business.industry ,Fototerapia ,Narrow band uvb ,Dermatology ,Terapia PUVA ,Psoríase ,medicine.disease ,Raios Ultravioleta ,chemistry.chemical_compound ,Liver disease ,Refractory ,chemistry ,Psoriasis ,medicine ,Severe psoriasis ,Medical prescription ,business ,Psoralen - Abstract
BACKGROUND Moderate and severe forms of psoriasis require phototherapy and / or systemic medications. Both UVA and UVB can be used to treat cases of moderate and severe psoriasis, and the effectiveness of both has been proven. OBJECTIVE to access the prescription behavior relating to two types of phototherapy for treating psoriasis refractory to topical treatment: narrowband UVB (NB-UVB) or psoralen plus UVA phototherapy (PUVA). METHODS Between January 2006 and December 2007, patients referred to two phototherapy services were included in this study. Data on the cases and on the type of prescription were collected retrospectively. RESULTS Among the 67 studied patients, 51 (76%) were treated with narrowband UVB. The reasons for the indication were the presence of the guttate type of psoriasis (22%), the presence of thin plaques (15%), the use of drugs that affected photosensitivity (15%), age less than 20 years (9%), skin type I (9%), and liver disease (6%). The remaining 16 (24%) were treated with PUVA. The main indication for this therapy was the severity of the disease (15%), followed by the presence of skin type IV (9%). CONCLUSIONS Prescriptions of narrowband UVB exceeded those of PUVA because of fewer contraindications and fewer possible side effects, and because it was a more practical option.
- Published
- 2009
68. Frequency and Main Sites of Allergic Contact Dermatitis Caused by Nail Varnish
- Author
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Ida Duarte, Camila Almeida Santos, Débora Cadore de Farias, Rosana Lazzarini, and Andréia Iam Tsai
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Toluenesulfonamide formaldehyde resin ,Varnish ,Cosmetics ,Dermatology ,Young Adult ,medicine ,Humans ,Immunology and Allergy ,Outpatient clinic ,In patient ,Child ,Allergic contact dermatitis ,Aged ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,stomatognathic diseases ,medicine.anatomical_structure ,visual_art ,Dermatitis, Allergic Contact ,visual_art.visual_art_medium ,Nail (anatomy) ,Female ,business ,Contact dermatitis ,Brazil - Abstract
BACKGROUND Liquid nail varnish has been used since 1919, and allergic contact dermatitis (ACD) has been recognized for at least 80 years, but it is difficult for nonspecialists to identify this condition. OBJECTIVES (1) To verify the frequency of ACD from nail varnish in patients with a presumptive diagnosis of contact dermatitis seen at an outpatient clinic, (2) to characterize the groups studied according to site of skin disorder, and (3) to determine the main sensitizer related to varnish. METHODS Patients with a final diagnosis of ACD caused by nail varnish were assessed by means of retrospective analysis of medical charts and protocols used in the clinic from January 1996 to December 2006. Patch tests with the Brazilian standard series and a complementary series were applied to all patients. RESULTS Diagnosis of ACD from nail varnish was made in 8% of cases (157 of 1,971). The most affected sites were the face and neck; however, involvement of some uncommon areas, such as periungual and perianal regions, was also observed. CONCLUSIONS ACD from nail polishes is a common event and recognition of the condition must be improved. Toluenesulfonamide formaldehyde resin (TSFR) was the most common allergen in the group studied.
- Published
- 2008
69. Contact dermatitis in elderly patients
- Author
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Ida Duarte, Clarice Kobata, and Rosana Lazzarini
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Adult ,medicine.medical_specialty ,Population ,Dermatitis ,Dermatology ,Patch tests ,Elderly ,Age groups ,medicine ,education ,Allergic contact dermatitis ,Nitrofurazone ,education.field_of_study ,Testes do emplastro ,Adult patients ,Adulto ,business.industry ,Idoso ,medicine.disease ,Promethazine ,Surgery ,Dermatite de contato ,Dermatology clinic ,business ,contact ,medicine.drug - Abstract
FUNDAMENTOS: A dermatite alérgica de contato é freqüente, com variações de acordo com o grupo estudado. OBJETIVOS: Verificar a freqüência da dermatite alérgica de contato em idosos; demonstrar os principais sensibilizantes nesse grupo; comparar os resultados dos testes epicutâneos com um grupo de adultos atendidos no mesmo período. PACIENTES: Durante o período 1998-2003, entre os pacientes submetidos aos testes de contato na Clínica de Dermatologia da Santa Casa de São Paulo, selecionaram-se idosos (>65 anos) e adultos (20-65 anos). RESULTADOS: Foram avaliados 80 (9%) idosos e 581 (63%) adultos. Entre os idosos, 70 tiveram testes positivos, e 10, negativos. Nos adultos, 436 apresentaram testes positivos, e 145, negativos. A diferença entre os grupos em relação ao número de testes positivos e negativos foi estatisticamente significante (p= 0,02). Demonstrou-se maior freqüência de sensibilização nos idosos às seguintes substâncias - sulfato de níquel (p=0,001), perfume-mix (p=0,004), neomicina (p=0,0008), nitrofurazona (p=0,02), prometazina (p=0,03) e benzocaína (p=0,007). CONCLUSÕES: A dermatite alérgica de contato nos idosos é comum como em outras faixas etárias. As substâncias relacionadas aos medicamentos tópicos são importantes agentes etiológicos da dermatite alérgica de contato nesse grupo. BACKGROUND: Allergic contact dermatitis is a frequent condition and varies according to the population studied. OBJECTIVES: To verify the frequency of allergic contact dermatitis in elderly patients; to demonstrate the main sensitizers in this age group; to compare the results of the contact tests with those of a group of adults seen in the same period. Patients: From 1998 to 2003, elderly (over 65 years), and adults (aged 20-65 years) were selected among patients submitted to contact tests at the Dermatology Clinic of [Hospital] Santa Casa de Sao Paulo. RESULTS: Eighty (9%) elderly and 581(63%) adult patients were assessed; 70 elderly patients had positive tests and 10 had negative tests. In the adult group, 436 had positive tests and 145 negative tests. The difference between the groups was statistically significant (p=0.02). The most frequent sensitizers in the elderly group were nickel sulfate (p=0.001), fragrance-mix (p=0.004), neomycin (p=0.0008), nitrofurazone (p=0.02), promethazine (p=0.03) and benzocaine (p=0.007). CONCLUSIONS: Allergic contact dermatitis in the elderly is as frequent as in other age groups. The substances related to topical medicines are important etiologic agents of allergic contact dermatitis in elderly individuals.
- Published
- 2007
70. [Malignant acanthosis nigricans: report of a case]
- Author
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Rosana, Lazzarini, Karine, Simone, Gabriela, Queiroz, Isabela, Courral, Maria Elisa, Magliari, Cecilia Kauffman Rutemberg, Feder, and Rute, Lellis
- Subjects
Adult ,Hypopharynx ,Lung Neoplasms ,Paraneoplastic Syndromes ,Asymptomatic Diseases ,Humans ,Female ,Pharyngeal Neoplasms ,Acanthosis Nigricans - Abstract
The authors present a case of a 44-year-old patient with a disseminated dermatosis diagnosed as acanthosis nigricans. The patient was a smoker and investigation of the cause of her skin lesions resulted in discovery of an asymptomatic metastatic carcinoma in the laryngopharanx, probably of pulmonary origin.
- Published
- 2014
71. Acantose nigricante maligna: realato de caso
- Author
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Rosana Lazzarini, Maria Elisa Magliari, Rute Facchini Lellis, Gabriela Queiroz, Isabela Courral, Cecilia Kauffman Rutemberg Feder, and Karine Simone
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,sindromes papaneoplasicas, acantose nigricans ,Dermatology ,General Medicine ,business - Abstract
Os autores apresentam um caso de uma paciente de 44 anos , tabagista, com dermatose disseminada diagnosticada como acantose nigricante. As lesoes da pele levaram ao diagnostico de metatase de carcinoma provavelmente de origem pulmonar, localizado na regiao laringofaringea, ate entao assintomatico.
- Published
- 2014
72. Hand Eczema: Evaluation of 250 Patients
- Author
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Rosana Lazzarini, Ida Duarte, and Jane Terumi Nakano
- Subjects
Adult ,Male ,Allergy ,medicine.medical_specialty ,Adolescent ,Eczema ,Physical examination ,Hand Dermatoses ,Dermatology ,medicine.disease_cause ,Diagnosis, Differential ,Patient Education as Topic ,Risk Factors ,medicine ,Immunology and Allergy ,Humans ,Occupations ,Medical History Taking ,Physical Examination ,Allergic contact dermatitis ,Aged ,medicine.diagnostic_test ,business.industry ,Atopic dermatitis ,Middle Aged ,Patch Tests ,medicine.disease ,Hand eczema ,Chronic Disease ,Etiology ,Female ,Irritation ,business ,Contact dermatitis - Abstract
Background: Hand eczema (HE) is a chronic multifactorial dermatosis with the presence of endogenous and exogenous factors in its pathogenesis. The etiologic diagnosis of hand eczema is often difficult. Objectives: The objectives of this study were (1) to detect clinical history and clinical examination data capable of differentiating HE types; (2) to determine the importance of patch tests for the etiologic diagnosis of HE; and (3) on the basis of the definitive diagnosis of HE type with the aid of patch tests, to obtain relevant data for appropriate patient guidance for the control of HE. Methods: A total of 250 patints with HE were studied over a period of 3 years (1993 to 1995). All patients were submitted to the battery of patch tests. Results and Conclusions: The results obtained led to the following conclusions: (1) Women are more predisposed to HE. (2) Work under moist conditions favors HE. (3) With respect to the regional location of HE, any region may be involved in any type of HE; however, involvement of the dorsal region is more common in allergic contact dermatitis (ACD), followed by contact dermatitis owing to primary irritation (ICD) and atopic dermatitis (AD). Location of HE on the dorsal surface of the fingers was mainly observed in ACD, followed by ICD and AD. (4) Patch tests should be part of the investigative routine of HE etiology. (5) The presence of allergy to metals in the clinical history of the patient in a relevant feature, because patch tests confirmed sensitization to nickel in 89% of cases. (6) Rubber components have high sensitization frequency in patients with HE. (7) When the patient reports worsening of HE after the use of rubber gloves, this indicates a probable sensitization to rubber components, mainly in patients with AD.
- Published
- 1998
73. Patch test standard series recommended by the Brazilian Contact Dermatitis Study Group during the 2006-2011 period
- Author
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Beatrice Mussio Fornazier Volpini, Nathalie Mie Suzuki, Rosana Lazzarini, Paulo Carrara de Castro, Ida Duarte, Andressa Sato de Aquino Lopes, and Greta Merie Tanaka
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Dermatitis ,Dermatology ,Patch tests ,Reference Values ,Alérgenos ,medicine ,Humans ,Allergic contact dermatitis ,Retrospective Studies ,Allergens ,Testes do emplastro ,Lanolin ,business.industry ,Communication ,Dermatitis, contact ,Testes cutâneos ,Patch test ,Retrospective cohort study ,Thimerosal ,Middle Aged ,Patch Tests ,medicine.disease ,Dermatitis, allergic contact ,Dermatite de contato ,Reference values ,RL1-803 ,Female ,business ,Skin tests ,Dermatite alérgica de contato ,Contact dermatitis ,allergic contact ,contact ,Brazil ,medicine.drug - Abstract
A retrospective study was carried out between 2006-2011. Six hundred and eighteen patients with suspected allergic contact dermatitis underwent the standard patch test series recommended by the Brazilian Contact Dermatitis Research Group. The aim of our study was to evaluate the variation of positive patch-test results from standard series year by year. The most frequently positive allergens were: nickel sulfate, thimerosal and potassium bichromate. Decrease of positive patch-test results over the years was statistically significant for: lanolin (p=0.01), neomycin (p=0.01) and anthraquinone (p=0.04). A follow-up study should be useful in determining which allergens could be excluded from standard series, as they may represent low sensitization risk. Estudo retrospectivo foi realizado entre 2006 e 2011 em 618 pacientes com hipótese diagnóstica de dermatite de contato submetidos à bateria padrão de testes de contato preconizada pelo Grupo Brasileiro de Estudos em Dermatite de Contato com o objetivo de avaliar a variação, a cada ano, da frequência de positividade para as substâncias da bateria. Os principais sensibilizantes foram sulfato de níquel, timerosal e bicromato de potássio. As substâncias com diminuição da frequência de sensibilização estatisticamente significante foram lanolina (p = 0,01), neomicina (p = 0,01) e antraquinona (p = 0,04). A continuação deste trabalho poderá contribuir para verificar aqueles componentes que poderão ser eliminados da bateria, por representarem pouco risco de sensibilização.
- Published
- 2012
74. Avaliação do tratamento da parapsoríase com fototerapia
- Author
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Karen Levy Korkes, Rosana Lazzarini, Ida Duarte, Clarice Kobata, Vanessa Alice M. Amorim, and Roberta Buense
- Subjects
Adult ,Male ,Cure rate ,medicine.medical_specialty ,Skin Neoplasms ,PUVA therapy ,medicine.medical_treatment ,Fototerapia ,Dermatology ,Terapia PUVA ,Ultraviolet therapy ,Cutaneous lymphoma ,Young Adult ,Medicine ,Humans ,Stage (cooking) ,Young adult ,Aged ,Aged, 80 and over ,Terapia ultravioleta ,Parapsoriasis ,business.industry ,Communication ,Follow up studies ,Middle Aged ,Phototherapy ,medicine.disease ,Lymphoma, T-Cell, Cutaneous ,Treatment Outcome ,Female ,Parapsoríase ,business ,Follow-Up Studies - Abstract
Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is still the subject of controversy. We evaluated the efficacy of phototherapy in the treatment of parapsoriasis and its relation with TCCL. Patients diagnosed with parapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Between 1 to 8 years following treatment the evolution of their disease was evaluated. In 62 patients the cure rate was 79.3% and 17.2% showed improvement of the lesions. Only two patients developed full blown T-cell cutaneous lymphoma. Phototherapy is an excellent treatment for parapsoriasis, with high cure rates, regardless of the type of phototherapy employed. Of the 62 patients under study, parapsoriasis showed no general tendency to progress to T-cell cutaneous lymphoma. Há controvérsias se parapsoríase pode evoluir para linfoma Cutâneo de Células T. Neste trabalho avaliou-se eficácia da fototerapia no tratamento da parapsoríase e sua relação com linfoma Cutâneo de Células T. Selecionaram-se pacientes com parapsoríase tratados com PUVA ou UVB-NB. Após um-oito anos do tratamento, pacientes foram contatatos para avaliar a evolução da doença. Em 62 pacientes, a taxa de cura foi de 79,3%;17,2% apresentaram melhora de lesões. Apenas dois pacientes evoluíram para linfoma Cutâneo de Células T. A fototerapia mostrou-se eficaz no tratamento da parapsoríase, independente do tipo de fototerapia utilizada. Nos casos estudados, parapsóríase não mostrou tendência a se desenvolver em linfoma Cutâneo de Células T.
- Published
- 2012
75. Evaluation of the permanence of skin sensitization to allergens in patients with allergic contact dermatitis
- Author
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Beatriz de Abreu Ribeiro Machado, Mariana de Figueiredo Silva, Rosana Lazzarini, Ida Duarte, and Andrey Augusto Malvestiti
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Dermatology ,Patch tests ,Clinical history ,Predictive Value of Tests ,Surveys and Questionnaires ,Diagnosis ,Medicine ,Humans ,In patient ,Prospective Studies ,Prospective cohort study ,Allergic contact dermatitis ,Sensitization ,Investigation ,business.industry ,Dermatitis, contact ,Skin sensitization ,Middle Aged ,Patch Tests ,medicine.disease ,Dermatitis, allergic contact ,medicine.anatomical_structure ,Predictive value of tests ,Female ,business ,Skin tests ,Contact dermatitis - Abstract
BACKGROUND: Background: Patch tests are an efficient method to confirm the etiological diagnosis of allergic contact dermatitis. OBJECTIVES: 1) To determine the permanence of results between two tests performed with an interval of at least one year, in patients with allergic contact dermatitis; 2) To compare the positive results according to rates of intensity; 3) To evaluate the permanence of sensitization according to each substance that was tested. METHODS: Patients with previous diagnosis of allergic contact dermatitis, confirmed by patch tests carried out between the years 2005 and 2008, underwent new testing, using the same methodology, and data was compared. RESULTS: A total of 1470 results of both tests on 49 patients were analyzed. The negative results remained in the second test in a rate of 96%, and 4% became positive (+) without relevance to the clinical history. Moreover, moderately (++) and strongly (+++) positive results were also maintained in, respectively, 86% and 100%. Nevertheless, weakly (+) positive results became negative in 65%. By ignoring all weakly (+) positive tests, the calculation of Kappa Index of Agreement Statistics between the two tests showed a value of 0.88. CONCLUSION: Patch tests showed to be reliable for negative, moderately (++) positive and strongly (+++) positive results, by reproducing the same standard of individual response to allergens. However, for weakly (+) positive results, tests were not reliable.
- Published
- 2011
76. Allergic contact dermatitis in private practice: what are the main sensitizers?
- Author
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Ida, Duarte, José, Antonio Jabur da Cunha, and Rosana, Lazzarini
- Subjects
Occupational Diseases ,Nickel ,Dermatitis, Allergic Contact ,Humans ,Parabens ,Private Practice ,Cobalt ,Cosmetics ,Allergens ,Patch Tests ,Perfume ,Retrospective Studies - Published
- 2011
77. Dermatological drugs, topical agents, and cosmetics
- Author
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Ida Duarte, Anita Rotter, Rosana Lazzarini, and Clarice Kobata
- Subjects
medicine.medical_specialty ,Scab formation ,business.industry ,media_common.quotation_subject ,Leukoderma ,medicine.disease ,Dermatology ,Cosmetics ,Hyperpigmentation ,Nephrotoxicity ,medicine.anatomical_structure ,Dermis ,Topical agents ,Medicine ,medicine.symptom ,business ,Adverse effect ,media_common - Abstract
Publisher Summary This chapter presents an overview of some dermatological drugs, topical agents, and cosmetics. Artecoll® is a permanent synthetic cosmetic filler substance, composed of 80% bovine collagen and 20% polymethylacrylate. It is used for augmentation of deep wrinkles and is injected subdermally. The collagen is biodegradable with 2–4 months; however, the polymethylacrylate microspheres are nonbiodegradable and long-lasting cosmetic effects are achieved. There have been reports of granulomatous reactions at the sites of injection. These reactions develop within a few months to several years after the procedure. Ocular argyrosis has been reported after repeated exposure to silver-containing compounds, usually from topical medicinal solutions or occupational exposure. Hydroquinone has been used in skin-bleaching formulations for the treatment of hyperpigmentation and can cause short- and mid-term adverse effects such as exogenous ochronosis and leukoderma en confetti, irritant reactions, and allergic reactions. Long-term adverse effects such as nephrotoxicity and carcinogenicity have only been demonstrated in animals. It has also been found that application of talc to wounds (erosions, ulcers) or crusting and/or exudative dermatosis can give rise to scab formation, infection, and foreign body granulomas in the dermis
- Published
- 2011
78. Dermatological drugs, topical agents, and cosmetics
- Author
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Anita Rotter, Rosana Lazzarini, and Ida Duarte
- Subjects
Allergy ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,medicine.disease ,Cosmetics ,Dermatology ,Tacrolimus ,Pimecrolimus ,Minoxidil ,medicine ,Adverse effect ,business ,Contact dermatitis ,Allergic contact dermatitis ,media_common ,medicine.drug - Abstract
Publisher Summary This chapter discusses the adverse effects of dermatological drugs, topical agents, and cosmetics such as hair dyes, henna, pimecrolimus, and minoxidil. Previous studies have suggested an association between the use of hair dyes and some cancers. Several studies have found an association of nonHodgkin's lymphoma with the use of hair dyes. In recent years, contact dermatitis after henna tattoos has been attributed to the sensitizer paraphenylenediamine, which is used as an antioxidant and favours a long-lasting effect of the henna. Allergic contact dermatitis from pimecrolimus in a patient with tacrolimus allergy has been described, showing the possibility of cross-reactions among topical immunomodulators. There have been reports of hypotension and tachycardia after chronic scalp application of minoxidil, suggesting that topical minoxidil can be systemically absorbed. Phototherapy and photochemotherapy with aminolevulinic acid is also related to complications, pain is the main adverse effect of photodynamic therapy. Tretinoin application has led to sunburn, hypersensitivity reactions, contact dermatitis, and desquamation.
- Published
- 2010
79. Progressive macular hypomelanosis: an epidemiological study and therapeutic response to phototherapy
- Author
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Ida, Duarte, Bianca Ishimoto Della, Nina, Maria Clara, Gordiano, Roberta, Buense, and Rosana, Lazzarini
- Subjects
Adult ,Hypopigmentation ,Male ,Young Adult ,Treatment Outcome ,Adolescent ,Recurrence ,Humans ,Female ,Ultraviolet Therapy ,PUVA Therapy ,Retrospective Studies - Abstract
Progressive macular hypomelanosis is a common dermatosis in various continents. Its cause is unknown and proposed treatments have had little effect.To determine epidemiological aspects of progressive macular hypomelanosis in patients referred to a phototherapy clinic between 1997 and 2008 and to evaluate therapeutic response to PUVA (psoralen + UVA) photochemotherapy or narrowband UVB phototherapy.Eighty-four patients with progressive macular hypomelanosis were evaluated. After 16 phototherapy sessions, therapeutic response was classified as: unchanged, slightly improved (50% of repigmentation), moderately improved (50-79% of repigmentation), much improved (80-99%) or cured (100%). After a minimum of three months, patients whose response was classified as cured or much improved were contacted by telephone to evaluate the persistence of the therapeutic response.Most of the patients were women (79%) and white (85%). Age at onset of progressive macular hypomelanosis ranged from 13 to 36 years. PUVA was prescribed for 27 patients and narrowband UVB phototherapy for 57. No significant difference was found between the outcomes obtained with PUVA and those obtained with narrowband UVB phototherapy (Fisher's exact test; p0.05). The majority of patients (81%) had 50% or more repigmentation, with 65% being classified as cured or much improved. Nevertheless, there was a recurrence of the lesions in 72% of patients.The fact that no patients were over 40 years of age suggests that progressive macular hypomelanosis is a self-limiting disease. Both PUVA and narrowband UVB are effective therapeutic options; however, they do not prevent recurrence of the disease.
- Published
- 2009
80. Associação de urticária de contato e dermatite alérgica de contato à borracha
- Author
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Ohalis Luanda Fernadez, Juliana Macedo Canosa, Rosana Lazzarini, and Ida Duarte
- Subjects
medicine.medical_specialty ,Latex Hypersensitivity ,Gloves, surgical ,Latex ,Urticaria ,Physical examination ,Dermatology ,Immunoglobulin E ,Látex ,Natural rubber ,medicine ,Urticária ,Allergic contact dermatitis ,Dermatite ocupacional ,Borracha ,Dermatites alérgicas de contato ,medicine.diagnostic_test ,biology ,business.industry ,Patch test ,Hipersensibilidade ao látex ,medicine.disease ,Dermatitis, occupational ,Latex hypersensitivity ,Dermatitis, allergic contact ,Luvas cirúrgicas ,visual_art ,biology.protein ,visual_art.visual_art_medium ,Eczematous dermatitis ,Rubber ,business ,Contact dermatitis - Abstract
Apresenta-se o caso de uma profissional da área da saúde que desenvolveu reação de hipersensibilidade dos tipos I e IV à borracha. O quadro clínico mostrava dermatite eczematosa no dorso das mãos. O teste de contato foi positivo para o grupo tiuram, assim como o teste aberto com fragmento de luva após exposição de 20 minutos. A dosagem de IgE sérica (Rast) mostrou-se relevante. As reações aos alérgenos da borracha são frequentes entre os profissionais da saúde, devido ao contato constante com esse material. We present a case of a healthcare professional that developed type I and IV hypersensitivity reactions to rubber. During the clinical examination the patient showed eczematous dermatitis of the hands. The patch test was positive for thiuram group and an open test with a piece of glove was positive after 20 minutes of exposure. Allergen-specific IgE test (RAST) was relevant. Reactions to rubber allergens are frequent among healthcare professionals due to constant contact with this material.
- Published
- 2009
81. What is the most common phototherapy prescription for psoriasis: NB-UVB or PUVA? Prescription behavior
- Author
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Ida, Duarte, José Antonio Jabur da, Cunha, Roberta Buense, Bedrikow, and Rosana, Lazzarini
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Middle Aged ,Phototherapy ,Severity of Illness Index ,Young Adult ,Prescriptions ,Humans ,Psoriasis ,Female ,Ultraviolet Therapy ,Child ,PUVA Therapy ,Aged ,Retrospective Studies - Abstract
Moderate and severe forms of psoriasis require phototherapy and / or systemic medications. Both UVA and UVB can be used to treat cases of moderate and severe psoriasis, and the effectiveness of both has been proven.to access the prescription behavior relating to two types of phototherapy for treating psoriasis refractory to topical treatment: narrowband UVB (NB-UVB) or psoralen plus UVA phototherapy (PUVA).Between January 2006 and December 2007, patients referred to two phototherapy services were included in this study. Data on the cases and on the type of prescription were collected retrospectively.Among the 67 studied patients, 51 (76%) were treated with narrowband UVB. The reasons for the indication were the presence of the guttate type of psoriasis (22%), the presence of thin plaques (15%), the use of drugs that affected photosensitivity (15%), age less than 20 years (9%), skin type I (9%), and liver disease (6%). The remaining 16 (24%) were treated with PUVA. The main indication for this therapy was the severity of the disease (15%), followed by the presence of skin type IV (9%).Prescriptions of narrowband UVB exceeded those of PUVA because of fewer contraindications and fewer possible side effects, and because it was a more practical option.
- Published
- 2009
82. Dermatite alérgica de contato a medicamentos de uso tópico: uma análise descritiva
- Author
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Rosana Lazzarini, Juliana Casagrande Tavoloni Braga, Ida Duarte, and Samia Leticia Ligabue
- Subjects
medicine.medical_specialty ,Neomicina/efeitos adversos ,Population ,Eczema ,Dermatology ,medicine.disease_cause ,Dermatite de contato/etiologia ,Allergen ,medicine ,education ,Allergic contact dermatitis ,Sensitization ,education.field_of_study ,business.industry ,Dermatitis, contact ,Patch test ,Neomycin ,Retrospective cohort study ,Neomicina ,medicine.disease ,medicine.anatomical_structure ,Dermatite de contato ,Etiology ,business ,medicine.drug - Abstract
FUNDAMENTOS: A dermatite de contato é uma dermatose comum e suas múltiplas causas dificultam seutratamento. OBJETIVO: O objetivo do estudo foi avaliar a frequência da sensibilização aos medicamentos de uso tópico, em serviço universitário; estudar as características da população afetada e identificar os principais sensibilizantes relacionados aos medicamentos tópicos. MÉTODOS: Realizou-se um estudo retrospectivo dos pacientes com hipótese diagnóstica de dermatite alérgica de contato e que foram submetidos a testes epicutâneos. Avaliaram-se os que tiveram diagnóstico final de dermatite alérgica de contato a medicamentos tópicos. RESULTADOS: Em um grupo de 329 pacientes submetidos a testes de contato, 42 (13%) tiveram testes de contato positivos e relevantes para medicamentos tópicos, pelo princípio ativo e/ou por outros componentes. Entre os testes positivos, 36 (85,7%) corresponderam aos princípios ativos e 28 (66,7%), a outros componentes das fórmulas, com alguns pacientes apresentando mais de um teste positivo. Entre os princípios ativos, a neomicina foi o mais frequente. CONCLUSÕES: Entre os pacientes estudados, a sensibilização aos medicamentos tópicos ocorreu em 13% dos casos, com discreta preferência pelo sexo feminino e maior número de casos entre pacientes brancos. Houve elevada frequência de dermatite alérgica de contato pela neomicina, agente de uso comum como automedicação e também como prescrição médica. BACKGROUND: Allergic Contact Dermatitis is a common type of dermatitis, but its multiple etiologies hinder its management. OBJECTIVE: the objective of this study was to evaluate the frequency of sensitization to topical drugs in a university center, to study the main characteristics of the affected population, and to identify the allergens related with the dermatitis. METHODS: a retrospective and descriptive study with patients submitted to patch tests. The study was conducted with subjects whose patch test to topical drugs was positive. RESULTS: 329 patients were submitted to patch tests and 42 (13%) had positive and relevant patch tests to topical drugs. Among these patients, 36 (85.7%) had positive patch tests to the principal component and 28 (66.7%) to the other components. Some patients had more than one sensitization. Neomycin was the most important allergen. CONCLUSIONS: Among the studied patients, sensitization to topical agents happened in 13% of the cases, with slight preference for females and Caucasians. There was elevated sensitization to neomycin, a popular agent among patients and medical doctors.
- Published
- 2009
83. Fototerapia na doença enxerto contra hospedeiro
- Author
-
Rosana Lazzarini, Roberta Buense Bedrikow, Paula Voltarelli, and Ida Duarte
- Subjects
Raios ultravioleta ,Doença enxerto-hospedeiro ,Fototerapia ,Dermatology ,Terapia Puva - Abstract
FUNDAMENTOS: A doença enxerto contra hospedeiro é um dos obstáculos ao sucesso do transplante de medula óssea, e o envolvimento cutâneo é freqüente. A fototerapia é utilizada devido à intensa atividade imunomoduladora local, sendo opção terapêutica adjuvante para as lesões cutâneas resistentes à terapia convencional. OBJETIVO: Realizar análise descritiva do tratamento da doença enxerto contra hospedeiro com fototerapia (Puva ou UVB de faixa estreita). MÉTODOS: Foram atendidos nove pacientes com manifestação cutânea da doença enxerto contra hospedeiro aguda ou crônica. Seis foram tratados com Puva, terapia de primeira escolha, e três com UVB de faixa estreita. As sessões foram realizadas três vezes por semana, e a resposta terapêutica avaliada após 12 sessões. RESULTADOS: Todos os pacientes com doença enxerto contra hospedeiro aguda mostraram melhora, com desaparecimento do eritema e do edema. Naqueles com doença crônica, observaram-se involução das lesões liquenóides e melhora da mobilidade daqueles com a forma esclerodermiforme. Dois pacientes apresentaram doença de evolução grave e foram a óbito. CONCLUSÃO: A fototerapia mostrou-se efetiva no tratamento das manifestações cutâneas da doença enxerto contra hospedeiro aguda e crônica. A Puva permite o controle da doença, podendo a UVB de faixa estreita ser opção para pacientes impossibilitados de usar medicação sistêmica.
- Published
- 2008
84. Frequency of occupational contact dermatitis in an ambulatory of dermatologic allergy
- Author
-
Ida, Duarte, Anita, Rotter, and Rosana, Lazzarini
- Subjects
Adult ,Male ,Young Adult ,Adolescent ,Dermatitis, Occupational ,Dermatitis, Allergic Contact ,Humans ,Female ,Middle Aged ,Patch Tests ,Ambulatory Care Facilities ,Brazil ,Aged - Abstract
Occupational contact dermatitis (OCD) corresponds to 80% of the cases of skin diseases related to work.To determine: the frequency of OCD in an ambulatory of allergy not specific for occupational dermatosis; the profile of these patients according to age, gender, color, profession, atopic history, duration and localization of the dermatosis; the diagnosed types of contact dermatitis; the main allergens and to compare the frequency of the main antigens with the results obtained from patients examined in the same period of time, without DCO.During the three-year period from 2003 to 2006, 630 patients were examined and submitted to a battery of standardized contact patch tests and those who were diagnosed with OCD were selected.Sixty-nine out of the 630 patients were diagnosed with OCD. The average age was 44.5 years. Forty-eight patients (70%of the cases) presented the disease on the hands. The most prevalent activities of patients suffering from the disease were household tasks (39%) and building construction (33%). The allergic contact dermatitis (ACD) occurred in 48 cases which represent 70% of the total number of cases and irritant contact dermatitis in 21 cases corresponding to 30% of the total number of cases. The main allergens were potassium dichromate 28 (41%), nickel sulfate 16 (23%) and carba-mix 16 (23%).OCD was present in 10.9% of the patients. Concerning age the group in which the disease was more commonly found corresponded to the most productive group of the population. ACD corresponded to 48 cases, probably influenced by the long period of evolution of the dermatosis. Metal and rubber chemicals were the commonest allergens.
- Published
- 2008
85. [Allergic contact dermatitis to topical drugs: a descriptive analysis]
- Author
-
Rosana, Lazzarini, Ida, Duarte, Juliana Casagrande Tavoloni, Braga, and Samia Leticia, Ligabue
- Subjects
Male ,Administration, Topical ,Dermatitis, Allergic Contact ,Humans ,Female ,Retrospective Studies - Abstract
Allergic Contact Dermatitis is a common type of dermatitis, but its multiple etiologies hinder its management.the objective of this study was to evaluate the frequency of sensitization to topical drugs in a university center, to study the main characteristics of the affected population, and to identify the allergens related with the dermatitis.a retrospective and descriptive study with patients submitted to patch tests. The study was conducted with subjects whose patch test to topical drugs was positive.329 patients were submitted to patch tests and 42 (13%) had positive and relevant patch tests to topical drugs. Among these patients, 36 (85.7%) had positive patch tests to the principal component and 28 (66.7%) to the other components. Some patients had more than one sensitization. Neomycin was the most important allergen.Among the studied patients, sensitization to topical agents happened in 13% of the cases, with slight preference for females and Caucasians. There was elevated sensitization to neomycin, a popular agent among patients and medical doctors.
- Published
- 2008
86. Association of contact urticaria and allergic contact dermatitis to rubber
- Author
-
Ohalis Luanda, Fernadez, Juliana Macedo, Canosa, Rosana, Lazzarini, and Ida, Duarte
- Subjects
Adult ,Hypersensitivity, Immediate ,Dermatitis, Occupational ,Urticaria ,Health Personnel ,Dermatitis, Allergic Contact ,Humans ,Female ,Rubber ,Immunoglobulin E ,Patch Tests - Abstract
We present a case of a healthcare professional that developed type I and IV hypersensitivity reactions to rubber. During the clinical examination the patient showed eczematous dermatitis of the hands. The patch test was positive for thiuram group and an open test with a piece of glove was positive after 20 minutes of exposure. Allergen-specific IgE test (RAST) was relevant. Reactions to rubber allergens are frequent among healthcare professionals due to constant contact with this material.
- Published
- 2006
87. Contact dermatitis in adolescents
- Author
-
Clarice Kobata, Rosana Lazzarini, and Ida Duarte
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Dermatology ,Hand Dermatoses ,Sex Factors ,Nickel ,medicine ,Immunology and Allergy ,Humans ,Child ,Allergic contact dermatitis ,Sensitization ,business.industry ,Allergens ,Patch Tests ,medicine.disease ,Resins, Synthetic ,medicine.anatomical_structure ,Adolescent Behavior ,Dermatitis, Allergic Contact ,Female ,business ,Contact dermatitis ,Brazil ,Facial Dermatoses - Abstract
Background: Adolescents between the ages of 10 and 19 are exposed to a series of substances capable of causing contact dermatitis. Objectives: (1) To study the frequency and characteristics of allergic contact dermatitis in adolescents, (2) to characterize the group being studied, and (3) to verify the main sensitizing substances among this age group. Methods: From 1996 to 2001, 1,027 patients with a suspicion of contact dermatitis were analyzed, and patients between 10 and 19 years of age were selected. These patients were submitted to contact tests. Results: Among the 102 adolescents, 93 (91%) were female and 9 (9%) were male. The face was the area most affected by dermatosis. The contact tests were positive in 64 patients (56%), whereas in 45 (44%) they were negative. The main location of the contact dermatitis was the face (36%). The substances with higher frequencies of sensitization were nickel sulfate in 33 (31%) patients and tosylamide-formaldehyde resin in 13 (12%) patients. Conclusion: Contact dermatitis in adolescents was more frequent in white girls and on the face. The substances with greater frequency of sensitization were nickel sulfate and tosylamide-formaldehyde resin. These two substances are related to adolescent habits and behavior.
- Published
- 2004
88. Interference of the position of substances in an epicutaneous patch test battery with the occurrence of false-positive results
- Author
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Rosana Lazzarini, Ida Duarte, and Roberta Buense
- Subjects
Battery (electricity) ,medicine.medical_specialty ,Balsam of Peru ,Stereochemistry ,Mercapto mix ,Cross reactions ,Patch test ,Objective method ,Dermatology ,Allergens ,Patch Tests ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Dermatitis, Allergic Contact ,medicine ,Immunology and Allergy ,Humans ,False Positive Reactions ,Potassium dichromate ,Allergic contact dermatitis - Abstract
Background: Epicutaneous patch tests represent a practical and objective method that help in the etiologic diagnosis of allergic contact dermatitis. The technique of patch test application is an important factor in obtaining good results. Objectives: The aims of this study were (1) to determine whether the substances that form the test battery interfere with the patch test result and (2) to establish a rule for positioning the substances during patch test application. Methods: Two hundred patients were studied. The standard patch test battery was applied in 3 versions. The original, with the substances applied in alphabetical order was called version 1 (V1) and tested on the left back in all patients In 100 patients, on the right side, the same substances were tested but applied at different positions, avoiding the proximity of elements with a tendency to cross reaction and/or cosensitizing. This version of the battery was named version 2 (V2). Another 100 patients had V1 applied to the left back, and, on the right side, the version 3 of the battery (V3) was applied, consisting of the same allergens but placed close to those with a tendency for cross reaction and/or cosensitization. Results: In the group V1-V2, 163 results were positive in V1 and 124 in V2, with the difference being statistically significant ( P [lt ] .05). In the group V1-V3, 134 results were positive in V1 and 207 in V3, with the difference also being significant ( P [lt ] .005). The substances with the largest number of positive results, when tested close to other elements with a tendency for chemical affinity, were parabens, fragrance-mix, thimerosal, balsam of Peru, potassium dichromate, cobalt chloride, mercapto mix, and propylene glycol. Conclusions: (1) The substances of a patch test battery eliciting positive responses may interfere with test positivity to neighboring substances. (2) In addition to the already established techniques, the position of the substances forming the test battery needs to be determined; substances with a tendency to cross reaction or cosensitizing substances should be tested distant from one another, thus preventing the occurrence of false-positive results.
- Published
- 2002
89. Excited Skin Syndrome Associated with Patch-Test Application Technique
- Author
-
Rosana Lazzarini and Ida Duarte
- Subjects
business.industry ,Excited state ,Dermatitis, Allergic Contact ,Humans ,Immunology and Allergy ,Patch test ,Medicine ,Dermatology ,Allergens ,Cross Reactions ,Patch Tests ,business ,Biomedical engineering - Published
- 2006
90. Etiology of para-Phenylenediamine Sensitization: Hair Dye and Other Products
- Author
-
Rosana Lazzarini, Melissa Fusaro, and Ida Duarte
- Subjects
medicine.medical_specialty ,business.industry ,Hair Dyes ,Cosmetics ,Dermatology ,Phenylenediamines ,Para phenylenediamine ,medicine.anatomical_structure ,Dermatitis, Allergic Contact ,Hair dyes ,Etiology ,Humans ,Immunology and Allergy ,Medicine ,business ,Sensitization - Published
- 2008
91. ADOLESCENT CONTACT DERMATITIS
- Author
-
Clarice Kobata, Ida Duarte, and Rosana Lazzarini
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Immunology and Allergy ,Dermatology ,medicine.disease ,business ,Contact dermatitis - Published
- 2003
92. THE EXCITED SKIN SYNDROME: THE STUDY REALIZED IN 34 PATIENTS
- Author
-
Ida Duarte, Roberta Buense, and Rosana Lazzarini
- Subjects
Physics ,Nuclear magnetic resonance ,Excited state ,Immunology and Allergy ,Dermatology - Published
- 2001
93. THE INTERFERENCE OF THE SUBSTANCES POSITION THAT COMPOSE THE SERIES OF CONTACT TESTS IN THE FALSEPOSITIVE TESTS FORMATION
- Author
-
Rosana Lazzarini, Ida Duarte, and Roberta Buense
- Subjects
Series (mathematics) ,Position (vector) ,Immunology and Allergy ,Dermatology ,Interference (wave propagation) ,Algorithm ,Mathematics - Published
- 2001
94. Eczematous hand dermatitis. Evaluation of 250 patients
- Author
-
Ida, Duarte, Terumi, Nakano Jane, and Rosana, Lazzarini
- Published
- 1998
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