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241 results on '"Romanucci, Mariarita"'

51. Hypertrophic gastropathy associated with gastric sarcoma in a dog.

Author

Romanucci, Mariarita, Crisi, Paolo E., Giordano, Maria Veronica, Di Tommaso, Morena, Simeoni, Francesco, and Della Salda, Leonardo

Subjects
GLIAL fibrillary acidic protein, PARIETAL cells, GASTRIC mucosa, LABRADOR retriever, SARCOMA, GASTROINTESTINAL stromal tumors, INTESTINAL tumors
Abstract

A 14-y-old spayed female Labrador Retriever was presented with an 8-mo history of chronic vomiting. Abdominal ultrasound and gastrointestinal endoscopy revealed a mass protruding into the gastric lumen, with cytologic features suggestive of sarcoma. A partial gastrectomy was performed; the gastric body and antrum were thickened, with a cerebriform appearance of the mucosal surface. Histologic examination revealed a submucosal neoplastic proliferation of fusiform cells variably arranged in irregular bundles and scattered whorls. Fusiform cells strongly reacted to antibodies against vimentin, S100, and neuron-specific enolase; glial fibrillary acidic protein was moderately and multifocally expressed. Pancytokeratin, KIT, α–smooth muscle actin, and desmin were nonreactive. Histologic and immunohistochemical findings suggested a diagnosis of gastric sarcoma with features referable to a non-GIST (gastrointestinal stromal tumor), non–smooth muscle NIMT (non-angiogenic, non-lymphogenic intestinal mesenchymal tumor). The overlying gastric mucosa was thickened by elongated and dilated gastric glands, predominantly lined by intensely periodic acid-Schiff–stained mucous cells. This altered mucosal architecture was suggestive of Ménétrier-like disease. Although this disease has been hypothesized to predispose to gastric adenocarcinoma in dogs, an association with gastric sarcoma has not been documented previously in the veterinary literature, to our knowledge. [ABSTRACT FROM AUTHOR]

Published
2021
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53. Pathology in practice

Author

Romanucci, Mariarita, Massimini, Marcella, Valerii, Valeria, Malatesta, Daniela, Bongiovanni, Laura, and DELLA SALDA, Leonardo

Published
2017

58. Left atrial appendage rupture due to blunt chest trauma in an Eurasian otter (Lutra lutra)

Author

Romanucci, Mariarita, Fusillo, Romina, Marcelli, Manlio, Massimini, Marcella, Malatesta, Daniela, Bongiovanni, Laura, and DELLA SALDA, Leonardo

Subjects
Rupture, Male, lcsh:Veterinary medicine, Thoracic Injuries, Heart, Wounds, Nonpenetrating, Fatal Outcome, Heart Injuries, Italy, Blunt trauma, lcsh:SF600-1100, Animals, Atrial Appendage, lcsh:Animal culture, Eurasian otter, lcsh:SF1-1100, Otters
Abstract

An adult male Eurasian otter, found dead on the roadside, was submitted for post-mortem examination in April 2014 at the Veterinary Pathology Unit of the Faculty of Veterinary Medicine of Teramo, as part of the RECAL [RECovery and post mortem Analysis of Eurasian otters (Lutra lutra) in the National Park of Cilento, Vallo di Diano and Alburni (Salerno, Italy), and surrounding areas] project. Necropsy revealed an abundant hemothorax associated with multifocal, bilateral pulmonary contusions and lacerations, and a severe hemopericardium characterised by the presence of a wide blood clot in the intact pericardial sac. Two small laceration wounds of the left auricle were found at the base, along the atrioventricular groove, and on the outer free wall. Since myocardial and endocardial tissues showed no other gross and histopathological abnormalities, a left atrial appendage rupture resulting from a blunt chest trauma was diagnosed. Blunt traumatic cardiac rupture is a rarely reported, life-threatening condition in humans. To the best of our knowledge, this is the first report on a left atrial appendage rupture due to blunt chest trauma in veterinary literature. The possible occurrence of a cardiac rupture following a blunt thoracic injury should be taken into consideration in veterinary emergency care.

Published
2015

59. Role of nectin-4 in canine prostate cancer

Author

DELLA SALDA, Leonardo, Massimini, Marcella, Benazzi, Cinzia, Palmieri, Chiara, Malatesta, Daniela, Romanucci, Mariarita, Bongiovanni, Laura, Dondi, F., Passantino, G., and Perillo, A.

Published
2015

61. Oxidative Stress and Protein Quality Control Systems in the Aged Canine Brain as a Model for Human Neurodegenerative Disorders

Author

Romanucci, Mariarita and Della Salda, Leonardo

Subjects
Article Subject
Abstract

Aged dogs are considered the most suitable spontaneous animal model for studying normal aging and neurodegenerative diseases. Elderly canines naturally develop cognitive dysfunction and neuropathological hallmarks similar to those seen in humans, especially Alzheimer’s disease-like pathology. Pet dogs also share similar living conditions and diets to humans. Oxidative damage accumulates in the canine brain during aging, making dogs a valid model for translational antioxidant treatment/prevention studies. Evidence suggests the presence of detective protein quality control systems, involving ubiquitin-proteasome system (UPS) and Heat Shock Proteins (HSPs), in the aged canine brain. Further studies on the canine model are needed to clarify the role of age-related changes in UPS activity and HSP expression in neurodegeneration in order to design novel treatment strategies, such as HSP-based therapies, aimed at improving chaperone defences against proteotoxic stress affecting brain during aging.

Published
2015
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62. Negative hepatic computed tomographic attenuation pattern in a dog with vacuolar hepatopathy and hepatic fat accumulation secondary to cushing's syndrome.

Author

Carloni, Andrea, Paninarova, Michaela, Cavina, Damiano, Romanucci, Mariarita, Salda, Leonardo Della, Teodori, Simone, and Vignoli, Massimo

Abstract

This report describes an unusual computed tomographic (CT) hepatic pattern, characterized by negative attenuation values (from –19.59 to –28.85 Hounsfield Units, HU) in a canine patient with severe Cushing's syndrome. Attenuation values of the splenic parenchyma (63.26 HU) and abdominal fat (–118.34 HU) were within normal limits. The negative hepatic attenuation values allowed a CT diagnosis of severe hepatic fatty infiltration that was subsequently confirmed by tissue‐core biopsy and histopathological examination. [ABSTRACT FROM AUTHOR]

Published
2019
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67. Pathophysiology and pathological findings of heatstroke in dogs

Author

Romanucci, Mariarita and Della Salda,Leonardo

Subjects
Research and Reports [Veterinary Medicine]
Abstract

Mariarita Romanucci, Leonardo Della SaldaDepartment of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, ItalyAbstract: Canine heatstroke is a life-threatening condition resulting from an imbalance between heat dissipation and production, and characterized by a nonpyrogenic elevation in core body temperature above 41°C (105.8°F). Several exogenous and endogenous factors may predispose dogs to the development of heatstroke; on the other hand, adaptive mechanisms also exists which allow organisms to combat the deleterious effects of heat stress, which are represented by the cellular heat-shock response and heat acclimatization. The pathophysiology and consequences of heatstroke share many similarities to those observable in sepsis and are related to the interaction between the direct cytotoxicity of heat, the acute physiological alterations associated with hyperthermia, such as increased metabolic demand, hypoxia, and circulatory failure, and the inflammatory and coagulation responses of the host to the widespread endothelial and tissue injuries, which may culminate in disseminated intravascular coagulation, systemic inflammatory response syndrome, and multiple organ dysfunction.Keywords: thermoregulation, acclimatization, heat shock proteins, hyperthermia, systemic inflammatory response, multiple organ dysfunction

Published
2013

71. Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours

Author

Bongiovanni, Laura, D'Andrea, Alessandra, Romanucci, Mariarita, Malatesta, Daniela, Candolini, M, DELLA SALDA, Leonardo, Mechelli, L, Sforna, M, Brachelente, C., LS Pathobiologie, and dPB RMSC

Subjects
skin tumor, dog, epithelial-mesenchymal transition, veterinary(all)
Abstract

Background - Epithelial-to-mesenchymal transition (EMT) is a multistep process, important in tumour invasion and metastasis, characterized by loss of epithelial markers, redistribution of β-catenin and gain of mesenchymal markers. Hyposthesis/Objectives - Our aim was to investigate the immunohistochemical aberrant expression of cytokeratin, vimentin, survivin and heat shock protein72 (Hsp72) in canine cutaneous epithelial tumours, to understand the association of expression of these molecules with features of malignancy and their role in the EMT phenotype. Methods - Ten canine squamous cell carcinomas (SCCs; one with lymph node metastasis), 30 canine hair follicle tumours (six pilomatricomas, eight infundibular keratinizing acanthomas, six trichoepitheliomas and 10 trichoblastomas) and five normal skin samples were investigated by immunohistochemistry using specific anti-vimentin, -cytokeratin, -survivin and -Hsp72 antibodies. A semi-quantitative method was used to analyse the results, as follows: 0 to

Published
2012

73. Role of betha catenin in canine osteosarcoma

Author

Bongiovanni, Laura, Mazzocchetti, Francesca, Malatesta, Daniela, Romanucci, Mariarita, Buracco, Paolo, DE MARIA, Raffaella, Palmieri, Chiara, and Della Salda Leonardo

Published
2012

97. PDGFs and PDGFRs in canine osteosarcoma: New targets for innovative therapeutic strategies in comparative oncology

Author

LS Pathobiologie, dPB RMSC, Maniscalco, Lorella, Iussich, Selina, Morello, Emanuela, Martano, Marina, Biolatti, Bartolomeo, Riondato, Fulvio, Salda, Leonardo Della, Romanucci, Mariarita, Malatesta, Daniela, Bongiovanni, Laura, Tirrito, Federica, Gattino, Francesca, Buracco, Paolo, De Maria, Raffaella, LS Pathobiologie, dPB RMSC, Maniscalco, Lorella, Iussich, Selina, Morello, Emanuela, Martano, Marina, Biolatti, Bartolomeo, Riondato, Fulvio, Salda, Leonardo Della, Romanucci, Mariarita, Malatesta, Daniela, Bongiovanni, Laura, Tirrito, Federica, Gattino, Francesca, Buracco, Paolo, and De Maria, Raffaella

Published
2013

98. Epithelial-to-mesenchymal transition: Immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours

Author

LS Pathobiologie, dPB RMSC, Bongiovanni, Laura, D'Andrea, Alessandra, Romanucci, Mariarita, Malatesta, Daniela, Candolini, Melissa, Salda, Leonardo D., Mechelli, Luca, Sforna, Monica, Brachelente, Chiara, LS Pathobiologie, dPB RMSC, Bongiovanni, Laura, D'Andrea, Alessandra, Romanucci, Mariarita, Malatesta, Daniela, Candolini, Melissa, Salda, Leonardo D., Mechelli, Luca, Sforna, Monica, and Brachelente, Chiara

Published
2013

99. Pathophysiology and pathological findings of heatstroke in dogs

Author

Romanucci,Mariarita, Della Salda,Leonardo, Romanucci,Mariarita, and Della Salda,Leonardo

Abstract

Mariarita Romanucci, Leonardo Della SaldaDepartment of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, ItalyAbstract: Canine heatstroke is a life-threatening condition resulting from an imbalance between heat dissipation and production, and characterized by a nonpyrogenic elevation in core body temperature above 41°C (105.8°F). Several exogenous and endogenous factors may predispose dogs to the development of heatstroke; on the other hand, adaptive mechanisms also exists which allow organisms to combat the deleterious effects of heat stress, which are represented by the cellular heat-shock response and heat acclimatization. The pathophysiology and consequences of heatstroke share many similarities to those observable in sepsis and are related to the interaction between the direct cytotoxicity of heat, the acute physiological alterations associated with hyperthermia, such as increased metabolic demand, hypoxia, and circulatory failure, and the inflammatory and coagulation responses of the host to the widespread endothelial and tissue injuries, which may culminate in disseminated intravascular coagulation, systemic inflammatory response syndrome, and multiple organ dysfunction.Keywords: thermoregulation, acclimatization, heat shock proteins, hyperthermia, systemic inflammatory response, multiple organ dysfunction

Published
2013

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