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51. P073 - Mise en œuvre des méthodes d’« Optimal Matching » et de Classification ascendante hiérarchique pour l’étude du parcours de soins de patients âgés hospitalisés après une chute

Author

Mounié, M., primary, Fabre, D., additional, Rapp, T., additional, Blain, H., additional, Rolland, Y., additional, Tchalla, A., additional, Carcaillon-Bentata, L., additional, Nathalie, B., additional, Assous, L., additional, Apparitio, S., additional, Caby, D., additional, Reina, N., additional, Andre, L., additional, Demeulemeester, R., additional, Molinier, L., additional, and Costa, N., additional

Published
2023
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55. A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement

Author

Alvarez, M.N., Annweiler, C., Bernard, P.-L., Beswetherick, N., Bischoff-Ferrari, H.A., Bloch, F., Boddaert, J., Bonnefoy, M., Bousson, V., Bourdel-Marchasson, I., Capisizu, A., Che, H., Clara, J.G., Combe, B., Delignieres, D., Eklund, P., Emmelot-Vonk, M., Freiberger, E., Gauvain, J.-B., Goswami, N., Guldemond, N., Herrero, Á.C., Joël, M.-E., Jónsdóttir, A.B., Kemoun, G., Kiss, I., Kolk, H., Kowalski, M.L., Krajcík, Š., Kutsal, Y.G., Lauretani, F., Macijauskienė, J., Mellingsæter, M., Morel, J., Mourey, F., Nourashemi, F., Nyakas, C., Puisieux, F., Rambourg, P., Ramírez, A.G., Rapp, K., Rolland, Y., Ryg, J., Sahota, O., Snoeijs, S., Stephan, Y., Thomas, E., Todd, C., Treml, J., Adachi, R., Agnusdei, D., Body, J.-J., Breuil, V., Bruyère, O., Burckardt, P., Cannata-Andia, J.B., Carey, J., Chan, D.-C., Chapuis, L., Chevalley, T., Cohen-Solal, M., Dawson-Hughes, B., Dennison, E.M., Devogelaer, J.-P., Fardellone, P., Féron, J.-M., Perez, A.D., Felsenberg, D., Glueer, C., Harvey, N., Hiligsman, M., Javaid, M.K., Jörgensen, N.R., Kendler, D., Kraenzlin, M., Laroche, M., Legrand, E., Leslie, W.D., Lespessailles, E., Lewiecki, E.M., Nakamura, T., Papaioannou, A., Roux, C., Silverman, S., Henriquez, M.S., Thomas, T., Vasikaran, S., Watts, N.B., Weryha, G., Blain, H., Masud, T., Dargent-Molina, P., Martin, F.C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, C., Kanis, J.A., Reginster, J.Y., Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., and Strandberg, T.

Published
2016
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70. Meta‐analysis of individual‐patient data from EVAR‐1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years

Author

Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J.‐P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D. G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R.J., Bell, P. R. F., Greenhalgh, R. M., Whitaker, S.C., Poole‐Wilson, the late P.A., Ruckley, C. V., Campbell, W. B., Dean, M. R. E., Ruttley, M. S. T., Coles, E. C., Powell, J. T., Halliday, A., Gibbs, S. J., Brown, L. C., Epstein, D., Sculpher, M. J., Thompson, S. G., Hannon, R. J., Johnston, L., Bradbury, A. W., Henderson, M. J., Parvin, S. D., Shepherd, D. F. C., Greenhalgh, R. M., Mitchell, A. W., Edwards, P. R., Abbott, G. T., Higman, D. J., Vohra, A., Ashley, S., Robottom, C., Wyatt, M. G., Rose, J. D. G., Byrne, D., Edwards, R., Leiberman, D. P., McCarter, D. H., Taylor, P. R., Reidy, J. F., Wilkinson, A. R., Ettles, D. F., Clason, A. E., Leen, G. L. S., Wilson, N. V., Downes, M., Walker, S. R., Lavelle, J. M., Gough, M. J., McPherson, S., Scott, D. J. A., Kessell, D. O., Naylor, R., Sayers, R., Fishwick, N. G., Harris, P. L., Gould, D. A., Walker, M. G., Chalmers, N. C., Garnham, A., Collins, M. A., Beard, J. D., Gaines, P. A., Ashour, M. Y., Uberoi, R., Braithwaite, B., Whitaker, S. C., Davies, J. N., Travis, S., Hamilton, G., Platts, A., Shandall, A., Sullivan, B. A., Sobeh, M., Matson, M., Fox, A. D., Orme, R., Yusef, W., Doyle, T., Horrocks, M., Hardman, J., Blair, P. H. B., Ellis, P. K., Morris, G., Odurny, A., Vohra, R., Duddy, M., Thompson, M., Loosemore, T. M. L., Belli, A. M., Morgan, R., Adiseshiah, M., Brookes, J. A. S., McCollum, C. N., Ashleigh, R., Aukett, M., Baker, S., Barbe, E., Batson, N., Bell, J., Blundell, J., Boardley, D., Boyes, S., Brown, O., Bryce, J., Carmichael, M., Chance, T., Coleman, J., Cosgrove, C., Curran, G., Dennison, T., Devine, C., Dewhirst, N., Errington, B., Farrell, H., Fisher, C., Fulford, P., Gough, M., Graham, C., Hooper, R., Horne, G., Horrocks, L., Hughes, B., Hutchings, T., Ireland, M., Judge, C., Kelly, L., Kemp, J., Kite, A., Kivela, M., Lapworth, M., Lee, C., Linekar, L., Mahmood, A., March, L., Martin, J., Matharu, N., McGuigen, K., Morris‐Vincent, P., Murray, S., Murtagh, A., Owen, G., Ramoutar, V., Rippin, C., Rowley, J., Sinclair, J., Spencer, S., Taylor, V., Tomlinson, C., Ward, S., Wealleans, V., West, J., White, K., Williams, J., Wilson, L., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A. A., Buth, J., Pattynama, P. M., Verhoeven, E. L. G., van Voorthuisen, A. E., Blankensteijn, J. D., Balm, R., Buth, J., Cuypers, P. W. M., Grobbee, D. E., Prinssen, M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J. H. M., de Mol, B. A. J. M., van Bockel, J. H., Balm, R., Reekers, J., Tielbeek, X., Verhoeven, E. L. G., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., Prinssen, M., Balm, R., Blankensteijn, J. D., Buth, J., Cuypers, P. W. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., de Bruin, J. L., Baas, A. F., Blankensteijn, J. D., Prinssen, M., Buth, J., Tielbeek, A.V., Blankensteijn, J. D., Balm, R., Reekers, J. A., van Sambeek, M. R. H. M., Pattynama, P., Verhoeven, E. L. G., Prins, T., van der Ham, A. C., van der Velden, J. J. I. M., van Sterkenburg, S. M. M., ten Haken, G. B., Bruijninckx, C. M. A., van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A. W., Odink, H. F., de Smet, A. A. E. A., Vroegindeweij, D., van Loenhout, R. M. M., Rutten, M. J., Hamming, J. F., Lampmann, L. E. H., Bender, M. H. M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J. C., van Dortmont, L. M. C., van der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H. B., van Dop, H. R., de Mol van Otterloo, J. C. A., de Rooij, T. P. W., Smits, T. M., Yilmaz, E. N., Wisselink, W., van den Berg, F. G., Visser, M. J. T., van der Linden, E., Schurink, G. W. H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., Vermassen, F. E. G., Lederle, F. A., Freischlag, J. A., Kohler, T. R., Latts, E., Matsumura, J., Padberg, F. T., Jr, Kyriakides, T. C., Swanson, K. M., Guarino, P., Peduzzi, P., Antonelli, M., Cushing, C., Davis, E., Durant, L., Joyner, S., Kossack, the late A., Kyriakides, T. C., LeGwin, Mary, McBride, V., OʼConnor, T., Poulton, J., Stratton, the late S., Zellner, S., Snodgrass, A. J., Thornton, J., Swanson, K. M., Haakenson, C. M., Stroupe, K.T., Jonk, Y., Hallett, J. W., Hertzer, N., Towne, J., Katz, D. A., Karrison, T., Matts, J. P., Marottoli, R., Kasl, S., Mehta, R., Feldman, R., Farrell, W., Allore, H., Perry, E., Niederman, J., Randall, F., Zeman, M., Beckwith, the late D., OʼLeary, T. J., Huang, G. D., Latts, E., Bader, M., Ketteler, E. R., Kingsley, D. D., Marek, J. M., Massen, R. J., Matteson, B. D., Pitcher, J. D., Langsfeld, M., Corson, J. D., Goff, J. M., Jr, Kasirajan, K., Paap, C., Robertson, D. C., Salam, A., Veeraswamy, R., Milner, R., Kasirajan, K., Guidot, J., Lal, B. K., Busuttil, S. J., Lilly, M. P., Braganza, M., Ellis, K., Patterson, M. A., Jordan, W. D., Whitley, D., Taylor, S., Passman, M., Kerns, D., Inman, C., Poirier, J., Ebaugh, J., Raffetto, J., Chew, D., Lathi, S., Owens, C., Hickson, K., Dosluoglu, H. H., Eschberger, K., Kibbe, M. R., Baraniewski, H. M., Matsumura, J., Endo, M., Busman, A., Meadows, W., Evans, M., Giglia, J. S., El Sayed, H., Reed, A. B., Ruf, M., Ross, S., Jean‐Claude, J. M., Pinault, G., Kang, P., White, N., Eiseman, M., Jones, the late R., Timaran, C. H., Modrall, J. G., Welborn, M. B., III, Lopez, J., Nguyen, T., Chacko, J. K. Y., Granke, K., Vouyouka, A. G., Olgren, E., Chand, P., Allende, B., Ranella, M., Yales, C., Whitehill, T. A., Krupski, the late W. C., Nehler, M. R., Johnson, S. P., Jones, D. N., Strecker, P., Bhola, M. A., Shortell, C. K., Gray, J. L., Lawson, J. H., McCann, R., Sebastian, M.W., Kistler Tetterton, J., Blackwell, C., Prinzo, P. A., Lee, N., Padberg, F. T., Jr, Cerveira, J. J., Lal, B. K., Zickler, R. W., Hauck, K. A., Berceli, S. A., Lee, W. A., Ozaki, C. K., Nelson, P. R., Irwin, A. S., Baum, R., Aulivola, B., Rodriguez, H., Littooy, F. N., Greisler, H., OʼSullivan, M. T., Kougias, P., Lin, P. H., Bush, R. L., Guinn, G., Bechara, C., Cagiannos, C., Pisimisis, G., Barshes, N., Pillack, S., Guillory, B., Cikrit, D., Lalka, S. G., Lemmon, G., Nachreiner, R., Rusomaroff, M., OʼBrien, E., Cullen, J. J., Hoballah, J., Sharp, W. J., McCandless, J. L., Beach, V., Minion, D., Schwarcz, T. H., Kimbrough, J., Ashe, L., Rockich, A., Warner‐Carpenter, J., Moursi, M., Eidt, J. F., Brock, S., Bianchi, C., Bishop, V., Gordon, I. L., Fujitani, R., Kubaska, S. M., III, Behdad, M., Azadegan, R., Ma Agas, C., Zalecki, K., Hoch, J. R., Carr, S. C., Acher, C., Schwarze, M., Tefera, G., Mell, M., Dunlap, B., Rieder, J., Stuart, J. M., Weiman, D. S., Abul‐Khoudoud, O., Garrett, H. E., Walsh, S. M., Wilson, K. L., Seabrook, G. R., Cambria, R. A., Brown, K. R., Lewis, B. D., Framberg, S., Kallio, C., Barke, R. A., Santilli, S. M., dʼAudiffret, A. C., Oberle, N., Proebstle, C., Johnson, L. L., Jacobowitz, G. R., Cayne, N., Rockman, C., Adelman, M., Gagne, P., Nalbandian, M., Caropolo, L. J., Pipinos, I. I., Johanning, J., Lynch, T., DeSpiegelaere, H., Purviance, G., Zhou, W., Dalman, R., Lee, J. T., Safadi, B., Coogan, S. M., Wren, S. M., Bahmani, D. D., Maples, D., Thunen, S., Golden, M. A., Mitchell, M. E., Fairman, R., Reinhardt, S., Wilson, M. A., Tzeng, E., Muluk, S., Peterson, N. M., Foster, M., Edwards, J., Moneta, G. L., Landry, G., Taylor, L., Yeager, R., Cannady, E., Treiman, G., Hatton‐Ward, S., Salabsky, the late B., Kansal, N., Owens, E., Estes, M., Forbes, B. A., Sobotta, C., Rapp, J. H., Reilly, L. M., Perez, S. L., Yan, K., Sarkar, R., Dwyer, S. S., Perez, S., Chong, K., Kohler, T. R., Hatsukami, T. S., Glickerman, D. G., Sobel, M., Burdick, T. S., Pedersen, K., Cleary, P., Back, M., Bandyk, D., Johnson, B., Shames, M., Reinhard, R. L., Thomas, S. C., Hunter, G. C., Leon, L. R., Jr, Westerband, A., Guerra, R. J., Riveros, M., Mills, J. L., Sr, Hughes, J. D., Escalante, A. M., Psalms, S. B., Day, N. N., Macsata, R., Sidawy, A., Weiswasser, J., Arora, S., Jasper, B. J., Dardik, A., Gahtan, V., Muhs, B. E., Sumpio, B. E., Gusberg, R. J., Spector, M., Pollak, J., Aruny, J., Kelly, E. L., Wong, J., Vasilas, P., Joncas, C., Gelabert, H. A., DeVirgillio, C., Rigberg, D. A., Cole, L., Becquemin, J.‐P., Marzelle, J., Becquemin, J.‐P., Sapoval, M., Becquemin, J.‐P., Favre, J.‐P., Watelet, J., Lermusiaux, P., Sapoval, M., Lepage, E., Hemery, F., Dolbeau, G., Hawajry, N., Cunin, P., Harris, P., Stockx, L., Chatellier, G., Mialhe, C., Fiessinger, J.‐N., Pagny, L., Kobeiter, H., Boissier, C., Lacroix, P., Ledru, F., Pinot, J.‐J., Deux, J.‐F., Tzvetkov, B., Duvaldestin, P., Watelet, J., Jourdain, C., David, V., Enouf, D., Ady, N., Krimi, A., Boudjema, N., Jousset, Y., Enon, B., Blin, V., Picquet, J., LʼHoste, P., Thouveny, F., Borie, H., Kowarski, S., Pernes, J.‐M., Auguste, M., Becquemin, J.‐P., Desgranges, P., Allaire, E., Marzelle, J., Kobeiter, H., Meaulle, P.‐Y., Chaix, D., Juliae, P., Fabiani, J. N., Chevalier, P., Combes, M., Seguin, A., Belhomme, D., Sapoval, M., Baque, J., Pellerin, O., Favre, J. P., Barral, X., Veyret, C., Watelet, J., Peillon, C., Plissonier, D., Thomas, P., Clavier, E., Lermusiaux, P., Martinez, R., Bleuet, F., C, Dupreix, Verhoye, J. P., Langanay, T., Heautot, J. F., Koussa, M., Haulon, S., Halna, P., Destrieux, L., Lions, C., Wiloteaux, S., Beregi, J. P., Bergeron, P., Pinot, J.‐J., Patra, P., Costargent, A., Chaillou, P., DʼAlicourt, A., Goueffic, Y., Cheysson, E., Parrot, A., Garance, P., Demon, A., Tyazi, A., Pillet, J.‐C., Lescalie, F., Tilly, G., Steinmetz, E., Favier, C., Brenot, R., Krause, D., Cercueil, J. P., Vahdat, O., Sauer, M., Soula, P., Querian, A., Garcia, O., Levade, M., Colombier, D., Cardon, J.‐M., Joyeux, A., Borrelly, P., Dogas, G., Magnan, P.‐É., Branchereau, A., Bartoli, J.‐M., Hassen‐Khodja, R., Batt, M., Planchard, P.‐F., Bouillanne, P.‐J., Haudebourg, P., Bayne, J., Gouny, P., Badra, A., Braesco, J., Nonent, M., Lucas, A., Cardon, A., Kerdiles, Y., Rolland, Y., Kassab, M., Brillu, C., Goubault, F., Tailboux, L., Darrieux, H., Briand, O., Maillard, J.‐C., Varty, K., and Cousins, C.

Published
2017
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77. ASSOCIATIONS BETWEEN MULTIDOMAIN LIFESTYLE INTERVENTIONS AND INTRINSIC CAPACITY DOMAINS DURING AGING: A NARRATIVE REVIEW

Author

Fourteau, M., Virecoulon Giudici, K., Rolland, Y., Vellas, B., and de Souto Barreto, P.

Subjects
macromolecular substances, Article
Abstract

Background: Recently, the World Health Organization defined five domains of intrinsic capacity (IC), composed of physical and mental capacities linked to body functions, and that contribute to healthy aging: locomotion, cognition, psychological, vitality and sensorial. In the past decade, studies investigating the effects of concomitant lifestyle interventions (also called multidomain interventions) on one or several IC domains have been developed. The aim of this study is to synthetize the scientific literature about the associations between multidomain lifestyle interventions and IC domains. Methods: We conducted a narrative review of randomized controlled trials examining the effects of multidomain lifestyle interventions on at least one IC domain among older people. Multidomain intervention was defined as the presence of at least two of the following lifestyle interventions: physical activity/exercise, nutrition, cognitive stimulation, and management of cardiovascular risk factors (eg, smoking, alcohol consumption). Results: Multidomain interventions were associated with improvements on locomotion (as measured by performance-based tests of lower-limb function) and vitality (as measured by handgrip strength); benefits on cognitive function were also found, in particular among populations at increased risk of dementia and when operationalizing strong multidomain interventions (eg, using regular exercise training instead of physical activity advices). No study investigated the effects of multidomain lifestyle interventions on the sensorial domain (hearing and/or vision). The modalities composing the multidomain interventions and intervention length, as well as study population, substantially varied across studies; the most common combination of interventions was physical activity- and nutritional-related interventions. Conclusion: Available evidence is still limited, but literature suggests a positive effect of multidomain lifestyle interventions on IC domains, in particular locomotion. Further studies are still needed on this topic, in particular, studies exploring the effects of multidomain lifestyle interventions on the sensorial domain, as well as on a composite measurement of all IC domains.

Published
2020

78. Lithospheric transdimensional ambient-noise tomography of W-Europe: implications for crustal-scale geometry of the W-Alps

Author

Nouibat, A., Stehly, L., Paul, A., Schwartz, S., Bodin, T., Dumont, T., Rolland, Y., Brossier, R., Cifalps Team, Alparray Working Group, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la Terre (ISTerre), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel-Université Grenoble Alpes (UGA), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Référentiel géologique de la France, CIfalps, ANR-15-CE31-0015,AlpArray-FR,Voir et comprendre les Alpes en 3D, de la croûte au manteau(2015), ANR-11-EQPX-0040,RESIF-CORE,Réseau sismologique et géodésique français : l'équipement fondamental(2011), ANR-10-LABX-0056,OSUG@2020,Innovative strategies for observing and modelling natural systems(2010), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), and Environnements, Dynamiques et Territoires de la Montagne (EDYTEM)

Subjects
Seismic tomography, 010504 meteorology & atmospheric sciences, Seismic noise, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Crustal structure, 010502 geochemistry & geophysics, 01 natural sciences, Europe, Geophysics, 13. Climate action, Geochemistry and Petrology, [SDU]Sciences of the Universe [physics], Surface waves and free oscillations, 0105 earth and related environmental sciences
Abstract

SUMMARYA full understanding of the dynamics of mountain ranges such as the Alps requires the integration of available geological and geophysical knowledge into a lithospheric-scale 3-D geological model. As a first stage in the construction of this geo-model, we derive a new 3-D shear wave velocity model of the Alpine region, with a spatial resolution of a few tens of kilometres, making it possible to compare with geological maps. We use four years of continuous vertical-component seismic noise records to compute noise correlations between more than 950 permanent broad-band stations complemented by ∼600 temporary stations from the AlpArray sea-land seismic network and the Cifalps and EASI linear arrays. A specific pre-processing is applied to records of ocean–bottom seismometers in the Liguro-Provençal basin to clean them from instrumental and oceanic noises. We first perform a 2-D transdimensional inversion of the traveltimes of Rayleigh waves to compute group-velocity maps from 4 to $150\, \mathrm{ s}$. The data noise level treated as an unknown parameter is determined with a Hierarchical Bayes method. A Fast Marching Eikonal solver is used to update ray path geometries during the inversion. We use next the group-velocity maps and their uncertainties to derive a 3-D probabilistic Vs model. The probability distributions of Vs at depth and the probability of presence of an interface are estimated at each location by exploring a set of 130 million synthetic four-layer 1-D Vs models. The obtained probabilistic model is refined using a linearized inversion. Throughout the inversion for Vs, we include the water column where necessary. Our Vs model highlights strong along-strike changes of the lithospheric structure, particularly in the subduction complex between the European and Adriatic plates. In the South-Western Alps, our model confirms the existence of a low-velocity structure at $50-80\, \mathrm{ km}$ depth in the continuation of the European continental crust beneath the subduction wedge. This deep low-velocity anomaly progressively disappears towards the North-Western and Central Alps. The European crust includes lower crustal low-velocity zones and a Moho jump of $\sim \, 8-12$ km beneath the western boundary of the External Crystalline Massifs of the North-Western Alps. The striking fit between our Vs model and the receiver function migrated depth section along the Cifalps profile documents the reliability of the Vs model. In light of this reliability and with the aim to building a 3-D geological model, we re-examine the geological structures highlighted along the Cifalps profile.

Published
2021

81. Description of 1,108 older patients referred by their physician to the “Geriatric Frailty Clinic (G.F.C) for assessment of frailty and prevention of disability” at the gerontopole

Author

Tavassoli, Neda, Guyonnet, S., Abellan Van Kan, G., Sourdet, S., Krams, T., Soto, M. -E., Subra, J., Chicoulaa, B., Ghisolfi, A., Balardy, L., Cestac, P., Rolland, Y., Andrieu, S., Nourhashemi, F., Oustric, S., Cesari, M., Vellas, B., and The “Geriatric Frailty Clinic (G.F.C) for Assessment of Frailty and Prevention of disability” Team

Published
2014
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87. Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19

Author

Bousquet, J. Czarlewski, W. Zuberbier, T. Mullol, J. Blain, H. Cristol, J.-P. De La Torre, R. Pizarro Lozano, N. Le Moing, V. Bedbrook, A. Agache, I. Akdis, C.A. Canonica, G.W. Cruz, A.A. Fiocchi, A. Fonseca, J.A. Fonseca, S. Gemicioǧlu, B. Haahtela, T. Iaccarino, G. Ivancevich, J.C. Jutel, M. Klimek, L. Kraxner, H. Kuna, P. Larenas-Linnemann, D.E. Martineau, A. Melén, E. Okamoto, Y. Papadopoulos, N.G. Pfaar, O. Regateiro, F.S. Reynes, J. Rolland, Y. Rouadi, P.W. Samolinski, B. Sheikh, A. Toppila-Salmi, S. Valiulis, A. Choi, H.-J. Kim, H.J. Anto, J.M.

Subjects
nervous system, musculoskeletal, neural, and ocular physiology, food and beverages, psychological phenomena and processes
Abstract

In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies. © 2021 S. Karger AG, Basel.

Published
2021

88. Spices to Control COVID-19 Symptoms: Yes, but Not Only

Author

Bousquet, J. Czarlewski, W. Zuberbier, T. Mullol, J. Blain, H. Cristol, J.-P. De La Torre, R. Le Moing, V. Lozano, N.P. Bedbrook, A. Agache, I. Akdis, C.A. Canonica, G.W. Cruz, A.A. Fiocchi, A. Fonseca, J.A. Fonseca, S. Gemicioǧlu, B. Haahtela, T. Iaccarino, G. Ivancevich, J.C. Jutel, M. Klimek, L. Kuna, P. Larenas-Linnemann, D.E. Melén, E. Okamoto, Y. Papadopoulos, N.G. Pfaar, O. Reynes, J. Rolland, Y. Rouadi, P.W. Samolinski, B. Sheikh, A. Toppila-Salmi, S. Valiulis, A. Choi, H.-J. Kim, H.J. Anto, J.M.

Abstract

There are large country variations in COVID-19 death rates that may be partly explained by diet. Many countries with low COVID-19 death rates have a common feature of eating large quantities of fermented vegetables such as cabbage and, in some continents, various spices. Fermented vegetables and spices are agonists of the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and spices are transient receptor potential ankyrin 1 and vanillin 1 (TRPA1/V1) agonists. These mechanisms may explain many COVID-19 symptoms and severity. It appears that there is a synergy between Nrf2 and TRPA1/V1 foods that may explain the role of diet in COVID-19. One of the mechanisms of COVID-19 appears to be an oxygen species (ROS)-mediated process in synergy with TRP channels, modulated by Nrf2 pathways. Spicy foods are likely to desensitize TRP channels and act in synergy with exogenous antioxidants that activate the Nrf2 pathway. © 2020

Published
2021

89. Extensional reactivation of the Penninic frontal thrust 3 Myr ago as evidenced by U-Pb dating on calcite in fault zone cataclasite

Author

Bilau, A., Rolland, Y., Schwartz, S., Godeau, N., Guihou, A., Deschamps, Pierre, Brigaud, B., Noret, A., Dumont, T., and Gautheron, C.

Abstract

In the Western Alps, the Penninic frontal thrust (PFT) is the main crustal-scale tectonic structure of the belt. This thrust transported the high-pressure metamorphosed internal units over the non-metamorphosed European margin during the Oligocene (34-29 Ma). Following the propagation of the compression toward the European foreland, the PFT was later reactivated as an extensional detachment associated with the development of the High Durance extensional fault system (HDFS). This inversion of tectonic displacement along a major tectonic structure has been widely emphasized as an example of extensional collapse of a thickened collisional orogen. However, the inception age of the extensional inversion remains unconstrained. Here, for the first time, we provide chronological constraints on the extensional motion of an exhumed zone of the PFT by applying U-Pb dating on secondary calcites from a fault zone cataclasite. The calcite cement and veins of the cataclasite formed after the main fault slip event, at 3.6 +/- 0.4-3.4 +/- 0.6 Ma. Crosscutting calcite veins featuring the last fault activity are dated at 2.6 +/- 0.3-2.3 +/- 0.3 Ma. delta C-13 and delta O-18 fluid signatures derived from these secondary calcites suggest fluid percolation from deep-seated reservoir at the scale of the Western Alps. Our data provide evidence that the PFT extensional reactivation initiated at least similar to 3.5 Myr ago with a reactivation phase at similar to 2.5 Ma. This reactivation may result from the westward propagation of the compressional deformation toward the external Alps, combined with the exhumation of external crystalline massifs. In this context, the exhumation of the dated normal faults is linked to the eastward transla- tion of the HDFS seismogenic zone, in agreement with the present-day seismic activity.

Published
2021

90. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author

Bousquet, J. Agache, I. Blain, H. Jutel, M. Ventura, M.T. Worm, M. Del Giacco, S. Benetos, A. Bilo, B.M. Czarlewski, W. Abdul Latiff, A.H. Al-Ahmad, M. Angier, E. Annesi-Maesano, I. Atanaskovic-Markovic, M. Bachert, C. Barbaud, A. Bedbrook, A. Bennoor, K.S. Berghea, E.C. Bindslev-Jensen, C. Bonini, S. Bosnic-Anticevich, S. Brockow, K. Brussino, L. Camargos, P. Canonica, G.W. Cardona, V. Carreiro-Martins, P. Carriazo, A. Casale, T. Caubet, J.-C. Cecchi, L. Cherubini, A. Christoff, G. Chu, D.K. Cruz, A.A. Dokic, D. El-Gamal, Y. Ebisawa, M. Eberlein, B. Farrell, J. Fernandez-Rivas, M. Fokkens, W.J. Fonseca, J.A. Gao, Y. Gavazzi, G. Gawlik, R. Gelincik, A. Gemicioğlu, B. Gotua, M. Guérin, O. Haahtela, T. Hoffmann-Sommergruber, K. Hoffmann, H.J. Hofmann, M. Hrubisko, M. Illario, M. Irani, C. Ispayeva, Z. Ivancevich, J.C. Julge, K. Kaidashev, I. Khaitov, M. Knol, E. Kraxner, H. Kuna, P. Kvedariene, V. Lauerma, A. Le, L.T.T. Le Moing, V. Levin, M. Louis, R. Lourenco, O. Mahler, V. Martin, F.C. Matucci, A. Milenkovic, B. Miot, S. Montella, E. Morais-Almeida, M. Mortz, C.G. Mullol, J. Namazova-Baranova, L. Neffen, H. Nekam, K. Niedoszytko, M. Odemyr, M. O’Hehir, R.E. Okamoto, Y. Ollert, M. Palomares, O. Papadopoulos, N.G. Panzner, P. Passalacqua, G. Patella, V. Petrovic, M. Pfaar, O. Pham-Thi, N. Plavec, D. Popov, T.A. Recto, M.T. Regateiro, F.S. Reynes, J. Roller-Winsberger, R.E. Rolland, Y. Romano, A. Rondon, C. Rottem, M. Rouadi, P.W. Salles, N. Samolinski, B. Santos, A.F. S Sarquis, F. Sastre, J. M. G. A. Schols, J. Scichilone, N. Sediva, A. Shamji, M.H. Sheikh, A. Skypala, I. Smolinska, S. Sokolowska, M. Sousa-Pinto, B. Sova, M. Stelmach, R. Sturm, G. Suppli Ulrik, C. Todo-Bom, A.M. Toppila-Salmi, S. Tsiligianni, I. Torres, M. Untersmayr, E. Urrutia Pereira, M. Valiulis, A. Vitte, J. Vultaggio, A. Wallace, D. Walusiak-Skorupa, J. Wang, D.-Y. Waserman, S. Yorgancioglu, A. Yusuf, O.M. Zernotti, M. Zidarn, M. Chivato, T. Akdis, C.A. Zuberbier, T. Klimek, L.

Abstract

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients. © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Published
2021

91. Ambient‐Noise Tomography of the Ligurian‐Provence Basin Using the AlpArray Onshore‐Offshore Network: Insights for the Oceanic Domain Structure.

Author

Nouibat, A., Stehly, L., Paul, A., Schwartz, S., Rolland, Y., Dumont, T., Crawford, W. C., and Brossier, R.

Subjects
BOUNDARY layer (Aerodynamics), MICROSEISMS, BACK-arc basins, RAYLEIGH waves, SURFACE waves (Seismic waves), OCEANIC crust, SEISMIC networks, TOMOGRAPHY
Abstract

We derive a three‐dimensional shear‐wave velocity model of the Ligurian‐Provence back‐arc basin (Northwestern Mediterranean Sea) using ocean‐bottom seismometers (AlpArray OBSs) and land stations from permanent and temporary seismic networks. The quality of OBS continuous records is enhanced by a specific processing that reduces instrumental and seabed‐induced noises (transients, tilt, compliance). To further improve the resolution of ambient‐noise tomography in the offshore area, we compute the Rayleigh‐wave part of the Green functions for OBS‐OBS pairs by using onshore stations as virtual sources. 2‐D group‐velocity maps and their uncertainties are computed in the 4–150 s period range by a transdimensional inversion of Rayleigh‐wave travel times. The dispersion data and their uncertainties are inverted for a probabilistic 3‐D shear‐wave velocity model that includes probability densities for Vs and for the depth of layer interfaces. The probabilistic model is refined by a linearized inversion that accounts for the water layer in the Ligurian Sea. Our S‐wave velocity and layer boundary probability models correspond well to a recent, high‐resolution P‐wave velocity cross‐section derived from controlled‐source seismic profiling along the Ligurian‐Provence basin axis. A joint interpretation of the P‐ and S‐wave velocity sections along this profile reveals a thin, anomalous oceanic crust of low P‐wave velocities but high S‐wave velocities, intruded by a gabbroic body. The illuminated part of the upper mantle appears to be devoid of serpentinization. Plain Language Summary: The Ligurian‐Provence basin (Northwestern Mediterranean Sea) is one of the Miocene‐Pliocene back‐arc basins that resulted from the retreat of the Adria subduction in the plate reorganization due to Africa‐Europe convergence. The crustal structure of the basin is still debated, even though it has been probed by active seismic profiling. We compute a high‐resolution shear‐wave velocity model of the Ligurian‐Provence basin and its margins by making optimal use of ambient‐noise recordings of seafloor broadband seismometers. In particular, we improve the usually low quality of surface‐wave signals in noise correlations between seafloor stations by involving correlations with land stations. The joint interpretation of our S‐wave velocity model with a P‐wave velocity section obtained in the basin axis by controlled‐source seismic profiling provides compelling evidence for the presence of a thick sediment pile above a thin, ∼4.5 km‐thick oceanic crust, intruded by gabbroic bodies emplaced at the crust‐mantle transition. These results show the potential of a joint interpretation of P‐ and S‐wave velocity models since they provide reliable answers to a number of debated questions on the petrological nature of the crust and uppermost mantle, in particular in the Ligurian‐Provence basin. Key Points: Efficient processing scheme to remove transients and reduce tilt and compliance from continuous ambient noise recorded by ocean‐bottom seismometers (OBSs)Computation of iterative correlations between OBSs based on a virtual reconstruction of the Rayleigh wavesThin, anomalous oceanic crust with gabbroic intrusions evidenced in the basin axis from a joint interpretation of Vs and Vp models [ABSTRACT FROM AUTHOR]

Published
2022
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92. Tools in the Assessment of Sarcopenia

Author

Cooper, C., Fielding, R., Visser, M., van Loon, L. J., Rolland, Y., Orwoll, E., Reid, K., Boonen, S., Dere, W., Epstein, S., Mitlak, B., Tsouderos, Y., Sayer, A. A., Rizzoli, R., Reginster, J. Y., and Kanis, J. A.

Published
2013
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