96 results on '"Rojo Sebastián A"'
Search Results
52. Neuronal nitric oxide synthase (nNOS, NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome
- Author
-
Félix Javier Jiménez-Jiménez, Margarita Arroyo-Solera, Elena García-Martín, Hortensia Alonso-Navarro, Ana Rojo-Sebastián, Lluisa Rubio, Esteban García-Albea, Carmen Martínez, Esther Cubo, José A. G. Agúndez, Belén Pilo-de-la-Fuente, Martín Zurdo, Laura Turpín-Fenoll, Teresa Adeva-Bartolomé, Jorge Millán-Pascual, José Francisco Plaza-Nieto, Marisol Calleja, and Francisco Navacerrada
- Subjects
Male ,Risk ,medicine.medical_specialty ,Genotyping Techniques ,NOS1 ,Single-nucleotide polymorphism ,Nitric Oxide Synthase Type I ,Biology ,Polymorphism, Single Nucleotide ,Cohort Studies ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,Restless Legs Syndrome ,mental disorders ,Genotype ,medicine ,Humans ,Genetic Predisposition to Disease ,Restless legs syndrome ,Allele frequency ,Biological Psychiatry ,Middle Aged ,medicine.disease ,Genotype frequency ,Psychiatry and Mental health ,Endocrinology ,Neurology ,Female ,Neurology (clinical) - Abstract
Several biochemical, neuropathological, and experimental data suggest a possible role of nitric oxide (NO) in the pathophysiology of restless legs syndrome (RLS). Two single nucleotide polymorphisms (SNPs) neuronal nitric oxide synthase (nNOS or NOS1) gene (rs7977109 and rs693534) have been found to be associated with the risk for RLS in Germans, although only one of them (rs7977109) remained as significant after multiple comparison tests. The aim of our study was to replicate the possible association between these SNPs and risk for RLS in the Spanish population. We studied the allelic and genotype frequencies of the SNPs rs7977109 and rs693534 in 205 patients with RLS and 328 healthy controls using TaqMan genotyping. The rs7977109 and rs693534 genotypes and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, ferritin levels, and response to dopaminergic or gabaergic agents. The rs7999109GA genotype was overrepresented in RLS patients with positive family history of RLS, and in patients with symptomatic response to clonazepam. The results of our study suggest that these two NOS1 SNPs are not related to the overall risk for RLS in the Spanish population.
- Published
- 2014
53. Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma
- Author
-
García-Sanz, Pablo, primary, Triviño, Juan Carlos, additional, Mota, Alba, additional, Pérez López, María, additional, Colás, Eva, additional, Rojo-Sebastián, Alejandro, additional, García, Ángel, additional, Gatius, Sonia, additional, Ruiz, María, additional, Prat, Jaime, additional, López-López, Rafael, additional, Abal, Miguel, additional, Gil-Moreno, Antonio, additional, Reventós, Jaume, additional, Matias-Guiu, Xavier, additional, and Moreno-Bueno, Gema, additional
- Published
- 2017
- Full Text
- View/download PDF
54. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome
- Author
-
Jiménez-Jiménez, Félix Javier, primary, García-Martín, Elena, additional, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán-Pascual, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Ortega-Cubero, Sara, additional, Pastor, Pau, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Albea, Esteban, additional, and Agúndez, José A. G., additional
- Published
- 2016
- Full Text
- View/download PDF
55. The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients
- Author
-
Gahete, Manuel D., primary, Rincón-Fernández, David, additional, Durán-Prado, Mario, additional, Hergueta-Redondo, Marta, additional, Ibáñez-Costa, Alejandro, additional, Rojo-Sebastián, Alejandro, additional, Gracia-Navarro, Francisco, additional, Culler, Michael D., additional, Casanovas, Oriol, additional, Moreno-Bueno, Gema, additional, Luque, Raúl M., additional, and Castaño, Justo P., additional
- Published
- 2016
- Full Text
- View/download PDF
56. Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
- Author
-
Hergueta-Redondo, Marta, primary, Sarrio, David, additional, Molina-Crespo, Ángela, additional, Vicario, Rocío, additional, Bernadó-Morales, Cristina, additional, Martínez, Lidia, additional, Rojo-Sebastián, Alejandro, additional, Serra-Musach, Jordi, additional, Mota, Alba, additional, Martínez-Ramírez, Ángel, additional, Castilla, Maria Ángeles, additional, González-Martin, Antonio, additional, Pernas, Sonia, additional, Cano, Amparo, additional, Cortes, Javier, additional, Nuciforo, Paolo G., additional, Peg, Vicente, additional, Palacios, José, additional, Pujana, Miguel Ángel, additional, Arribas, Joaquín, additional, and Moreno-Bueno, Gema, additional
- Published
- 2016
- Full Text
- View/download PDF
57. Supraclavicular Metastasis in Prostate Cancer Detected With 18F-Fluorocholine PET/CT Scan
- Author
-
Núñez Miller, R., Viera, J.C., Jover Díaz, R., Rojo Sebastián, A., Pozo, M.A., and Alfonso Alfonso, J.M.
- Published
- 2012
- Full Text
- View/download PDF
58. Discrepancies in reporting the CAG repeat lengths for Huntington's disease
- Author
-
Quarrell, Ow, Handley, O, O'Donovan, K, Dumoulin, C, Ramos Arroyo, M, Biunno, I, Bauer, P, Kline, M, Landwehrmeyer, Gb, Barth, K, Correia Guedes, L, Maria Finisterra, A, Bascuñana Garde, M, Bos, R, Ecker, D, Held, C, Koppers, K, Laurà, M, Martínez Descals, A, Mclean, T, Mestre, T, Minster, S, Monza, D, Townhill, J, Orth, M, Padieu, H, Paterski, L, Peppa, N, Koivisto, Sp, Rialland, A, Røren, N, Šašinková, P, Cubillo, Pt, van Walsem MR, Witjes Ané MN, Yudina, E, Zielonka, D, Zielonka, E, Zinzi, P, Bachoud Lévi AC, Bentivoglio, Ar, Bonelli, R, Burgunder, Jm, Dunnett, Sb, Ferreira, Jj, Handley, Oj, Heiberg, A, Illmann, T, Levey, J, Nielsen, Je, Päivärinta, M, Roos, Ra, Rojo Sebastián, A, Tabrizi, Sj, Vandenberghe, W, Verellen Dumoulin, C, Zaremba, J, Uhrova, T, Wahlström, J, Bonelli, Rm, Herranhof, B, Holl, A, Kapfhammer, Hp, Koppitz, M, Magnet, M, Otti, D, Painold, A, Reisinger, K, Scheibl, M, Hecht, K, Lilek, S, Müller, N, Schöggl, H, Ullah, J, Brugger, F, Hepperger, C, Hotter, A, Mahlknecht, P, Nocker, M, Seppi, K, Wenning, G, Buratti, L, Hametner, Em, Holas, C, Hussl, A, Mair, K, Poewe, W, Wolf, E, Zangerl, A, Braunwarth, Em, Ribaï, P, Flamez, A, Morez, V, de Raedt, S, Boogaerts, A, van Reijen, D, Klempíř, J, Kucharík, M, Roth, J, Hjermind, Le, Jakobsen, O, Stokholm, J, Hasholt, L, Nørremølle, A, Sørensen, Sa, Hiivola, H, Martikainen, K, Tuuha, K, Peippo, M, Sipponen, M, Kosinski, Cm, Milkereit, E, Probst, D, Sass, C, Schiefer, J, Schlangen, C, Werner, Cj, Gelderblom, H, Priller, J, Prüss, H, Spruth, Ej, Andrich, J, Hoffmann, R, Kraus, Ph, Muth, S, Prehn, C, Saft, C, Salmen, S, Stamm, C, Steiner, T, Strassburger, K, Lange, H, Friedrich, A, Hunger, U, Löhle, M, Schmidt, S, Storch, A, Wolz, A, Wolz, M, Lambeck, J, Zucker, B, Boelmans, K, Ganos, C, Hidding, U, Lewerenz, J, Münchau, A, Schmalfeld, J, Stubbe, L, Zittel, S, Heinicke, W, Longinus, B, Uni, M, Bürk, K, Möller, Jc, Rissling, I, Peinemann, A, Städtler, M, Weindl, A, Bechtel, N, Beckmann, H, Bohlen, S, Hölzner, E, Reilmann, R, Rohm, S, Rumpf, S, Schepers, S, Beister, A, Dose, M, Hammer, K, Kieni, J, Leythaeuser, G, Marquard, R, Raab, T, Richter, S, Selimbegovic Turkovic, A, Schrenk, C, Schuierer, M, Wiedemann, A, Buck, A, Connemann, J, Eschenbach, C, Landwehrmeyer, B, Lezius, F, Nepper, S, Niess, A, Süssmuth, S, Trautmann, S, Weydt, P, Cormio, C, Difruscolo, O, Sciruicchio, V, Serpino, C, de Tommaso, M, Capellari, S, Cortelli, P, Gallassi, R, Poda, R, Rizzo, G, Scaglione, C, Bertini, E, Ghelli, E, Ginestroni, A, Massaro, F, Mechi, C, Paganini, M, Piacentini, S, Pradella, S, Romoli, Am, Sorbi, S, Abbruzzese, G, Bandettini di Poggio, M, Di Maria, E, Ferrandes, G, Mandich, P, Marchese, R, Albanese, A, Di Bella, D, Di Donato, S, Gellera, C, Genitrini, S, Mariotti, C, Nanetti, L, Paridi, D, Soliveri, P, Tomasello, C, De Michele, G, Di Maio, L, Rinaldi, C, Valeria Russo, C, Salvatore, E, Tucci, T, Cannella, M, Codella, V, De Gregorio, F, De Nicola, N, Martino, T, Simonelli, M, Squitieri, F, Catalli, C, Di Giacopo, R, Fasano, A, Frontali, M, Guidubaldi, A, Ialongo, T, Jacopini, G, Loria, G, Modoni, A, Piano, C, Piccininni, C, Quaranta, D, Romano, Silvia, Soleti, F, Spadaro, M, van Hout MS, van Vugt JP, Marit de Weert, A, Bolwijn, Jj, Dekker, M, Leenders, Kl, van Oostrom JC, Dumas, Em, Jurgens, Ck, van den Bogaard SJ, 't Hart EP, Kremer, B, Verstappen, Cc, Aaserud, O, Wehus, R, Bjørgo, K, Fannemel, M, Gørvell, P, Retterstøl, L, Overland, T, Stokke, B, Bjørnevoll, I, Sando, Sb, Sitek, E, Slawek, J, Soltan, W, Boczarska Jedynak, M, Jasinska Myga, B, Opala, G, Kodowska Duda, G, Banaszkiewicz, K, Szczudlik, A, Rudziñska, M, Wójcik, M, Dec, M, Krawczyk, M, Bryl, A, Ciesielska, A, Klimberg, A, Marcinkowski, J, Sempoowicz, J, Samara, H, Janik, P, Kalbarczyk, A, Kwiecinski, H, Jamrozik, Z, Antczak, J, Jachinska, K, Rakowicz, M, Richter, P, Ryglewicz, D, Witkowski, G, Zdzienicka, E, Suek, A, Krysa, W, Guedes, L, Coelho, M, Mendes, T, Valadas, A, Cavaco, S, Damásio, J, Magalhães, M, Gago, M, Garrett, C, Guerra, Mr, Barrero, F, Morales, B, Cubo, E, Mariscal, N, Sánchez, J, Alonso Frech, F, Rabasa Perez, M, Fenollar, M, García, R, Quiroga, Pp, Vázquez Rivera, S, Villanueva, C, Bascuñana, M, Fatás Ventura, M, García Ribas, G, García de Yébenes, J, López Sendón Moreno JL, García Ruíz PJ, José Saiz Artiga, M, Sánchez, V, Noguera Perea, F, Lorenza, F, Torres, Mm, Reinante, G, Vivancos Moreau, L, Barbera, Ma, Badenes Guia, D, Hernanz, Lc, Catena, Jl, Ferrer, Pq, Tome Carruesco, G, Bas, J, Busquets, N, Calopa, M, Dalmau Elorza, M, Díez, C, López, A, Durán, S, Terol, S, Floriach Robert, M, Garzón Ruíz, B, González Casado, A, Haro Martínez, I, Viladrich, Cm, Càrdenas R, Pons i., Roca, E, Llesoy, Jr, Ruiz Idiago JM, Ruíz Vergara, M, Soriano García, S, Villa Riballo, A, Gorospe, A, Legarda, I, Arques, Pn, Torres Rodríguez MJ, Vives, B, Gaston, I, Bosca, M, Burguera, Ja, Garcia, Ac, Pålhagen, Se, Paucar, M, Svenningsson, P, Walldén Reza Soltani, T, Höglund, A, Sandström, B, Høsterey Ugander, U, Fredlund, G, Constantinescu, R, Neleborn Lingefjärd, L, Tedroff, J, Esmaeilzadeh, M, Winnberg, E, Burgunder, Y, Stebler, Y, Kaelin, A, Romero, I, Schüpbach, M, Zaugg, Sw, Jack, R, Matheson, K, Miedzybrodzka, Z, Rae, D, Simpson, S, Summers, F, Ure, A, Crooks, J, Curtis, A, de Souza, J, Rickards, H, Wright, J, Barker, Ra, Di Pietro, A, Fisher, K, Goodman, A, Hill, S, Kershaw, A, Mason, S, Paterson, N, Raymond, L, Bisson, J, Busse, M, Clenaghan, C, Ellison Rose, L, Hunt, S, Price, K, Rosser, A, Edwards, M, Hughes, T, Mcgill, M, Pearson, P, Porteous, M, Smith, P, Zeman, A, Causley, A, Harrower, T, Howcroft, D, Lambord, N, Rankin, J, Brockie, P, Foster, J, Johns, N, Mckenzie, S, Rothery, J, Thomas, G, Yates, S, Miller, J, Ritchie, S, Burrows, L, Fletcher, A, Harding, A, Laver, F, Silva, M, Thomson, A, Barnes, K, Chu, C, Hobson, E, Jamieson, S, Markova, I, Thomson, J, Toscano, J, Wild, S, Yardumian, P, Bourne, C, Clayton, C, Dipple, H, Clapton, J, Grant, J, Gross, D, Hallam, C, Middleton, J, Murch, A, Patino, D, Andrews, T, Dougherty, A, Kavalier, F, Golding, C, Lashwood, A, Robertson, D, Ruddy, D, Whaite, A, Patton, M, Peterson, M, Rose, S, Bruno, S, Chu, E, Doherty, K, Henley, S, Lahiri, N, Novak, M, Patel, A, Read, J, Rosser, E, Say, M, Tabrizi, S, Taylor, R, Warner, T, Wild, E, Arran, N, Callaghan, J, Craufurd, D, Fullam, R, Howard, L, Huson, S, Oughton, E, Partington Jones, L, Snowden, J, Sollom, A, Stopford, C, Thompson, J, Trender Gerhad, I, Verstraelen, N, Westmoreland, L, Nemeth, Ah, Suida, G, Harrison, D, Hughes, M, Parkinson, A, Soltysiak, B, Bandmann, O, Bradbury, A, Gill, P, Fairtlough, H, Fillingham, K, Foustanos, I, Tidswell, K., Kaelin, André, Quarrel O.W., Handley O., O'Donovan K., Dumoulin C., Ramos-Arroyo M., Biunno I., Bauer P., Kline M., Capellari S., Cortelli P., Gallassi R., Landwehrmeyer G.B., European Huntington's Disease Network., Neurology, Clinical sciences, Neuroprotection & Neuromodulation, Quarrell, Ow, Handley, O, O'Donovan, K, Dumoulin, C, Ramos Arroyo, M, Biunno, I, Bauer, P, Kline, M, Landwehrmeyer, Gb, European Huntington's Disease, Network, European Huntington's Disease, N. e. t. w. o. r. k., Rinaldi, Carlo, Salvatore, Elena, and DE MICHELE, Giuseppe
- Subjects
medicine.medical_specialty ,Concordance ,International Cooperation ,Diagnostic Errors/statistics & numerical data ,Nerve Tissue Proteins ,Guidelines as Topic ,Bioinformatics ,Sensitivity and Specificity ,Article ,Huntingtin Gene ,Huntington's disease ,Trinucleotide Repeats ,Internal medicine ,External quality assessment ,Genetics ,medicine ,Humans ,Nerve Tissue Proteins/genetics ,Diagnostic laboratory ,Genetic Testing ,Genetic Testing/methods/standards ,Allele ,Diagnostic Errors ,standard reference material ,Genetics (clinical) ,Alleles ,Huntingtin Protein ,ddc:618 ,business.industry ,international cooperation ,Nuclear Proteins ,Reproducibility of Results ,Reference Standards ,medicine.disease ,CAG repeat length ,Nuclear Proteins/genetics ,Huntington Disease ,Huntington Disease/diagnosis ,Mutation ,Medical genetics ,reproducibility of results ,mutation ,business ,Trinucleotide repeat expansion ,Huntington Disease/diagnosis/genetics ,Genetic Testing/methods - Abstract
Huntington's disease results from a CAG repeat expansion within the Huntingtin gene; this is measured routinely in diagnostic laboratories. The European Huntington's Disease Network REGISTRY project centrally measures CAG repeat lengths on fresh samples; these were compared with the original results from 121 laboratories across 15 countries. We report on 1326 duplicate results; a discrepancy in reporting the upper allele occurred in 51% of cases, this reduced to 13.3% and 9.7% when we applied acceptable measurement errors proposed by the American College of Medical Genetics and the Draft European Best Practice Guidelines, respectively. Duplicate results were available for 1250 lower alleles; discrepancies occurred in 40% of cases. Clinically significant discrepancies occurred in 4.0% of cases with a potential unexplained misdiagnosis rate of 0.3%. There was considerable variation in the discrepancy rate among 10 of the countries participating in this study. Out of 1326 samples, 348 were re-analysed by an accredited diagnostic laboratory, based in Germany, with concordance rates of 93% and 94% for the upper and lower alleles, respectively. This became 100% if the acceptable measurement errors were applied. The central laboratory correctly reported allele sizes for six standard reference samples, blind to the known result. Our study differs from external quality assessment (EQA) schemes in that these are duplicate results obtained from a large sample of patients across the whole diagnostic range. We strongly recommend that laboratories state an error rate for their measurement on the report, participate in EQA schemes and use reference materials regularly to adjust their own internal standards.
- Published
- 2012
59. Supraclavicular metastasis in prostate cancer detected with 18F-fluorocholine PET/CT
- Author
-
R, Núñez Miller, J C, Viera, R, Jover Díaz, A, Rojo Sebastián, M A, Pozo, and J M, Alfonso Alfonso
- Subjects
Male ,Fluorine Radioisotopes ,Lymphatic Metastasis ,Positron-Emission Tomography ,Humans ,Prostatic Neoplasms ,Adenocarcinoma ,Tomography, X-Ray Computed ,Clavicle ,Multimodal Imaging ,Aged ,Choline - Published
- 2011
60. Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population
- Author
-
Jiménez-Jiménez, Félix Javier, primary, García-Martín, Elena, additional, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán-Pascual, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Ortega-Cubero, Sara, additional, Pastor, Pau, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-De-La-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Albea, Esteban, additional, and Agúndez, José A.G., additional
- Published
- 2015
- Full Text
- View/download PDF
61. Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome
- Author
-
García-Martín, Elena, primary, Jiménez-Jiménez, Félix Javier, additional, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán-Pascual, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Ortega-Cubero, Sara, additional, Pastor, Pau, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Albea, Esteban, additional, and Agúndez, José A.G., additional
- Published
- 2015
- Full Text
- View/download PDF
62. Surgical Approach to a Large Left Adrenocortical Mass with Associated Tumour Thrombosis of the Left Renal Vein: Preservation of the Ipsilateral Kidney
- Author
-
Carlos Nuñez Mora, José M. García Mediero, Manuel Pérez Utrilla, Pedro M. Cabrera Castillo, and Alejandro Rojo Sebastián
- Subjects
Cisplatin ,Kidney ,medicine.medical_specialty ,business.industry ,Urology ,Adrenalectomy ,medicine.medical_treatment ,Obstetrics and Gynecology ,Left renal vein ,Case Report ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,Inferior vena cava ,Thrombosis ,Surgery ,Nephrotoxicity ,medicine.anatomical_structure ,medicine.vein ,medicine ,cardiovascular system ,Elective surgery ,business ,medicine.drug - Abstract
A sixty-years-old male with diagnosis of a left adrenal mass ( 1 4 6 × 9 9 × 1 2 6 mm) with associated tumour thrombosis of the left renal vein with no clear signs of thrombosis of the inferior vena cava was admitted for elective surgery Finally an adrenalectomy and excision of tumour thrombus preserving the ipsilateral kidney was made. Despite of the complex vascular management, this kind of approaches allow to preserve normal renal function in patients with future nephrotoxic treatment like cisplatin.
- Published
- 2009
63. Novel chemotherapy approaches in chemoradiation protocols
- Author
-
A. Rojo Sebastián, L. Chiva de Agustín, N. Carballo, V. Corraliza, J.F. García García, Lucía González-Cortijo, Ramon Colomer, Javier Hornedo, F. Lapuente Sastre, and Antonio González-Martín
- Subjects
Oncology ,Cisplatin ,Sorafenib ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Obstetrics and Gynecology ,Uterine Cervical Neoplasms ,Combined Modality Therapy ,Gemcitabine ,Carboplatin ,Radiation therapy ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Topotecan ,Female ,Erlotinib ,business ,medicine.drug - Abstract
Locally advanced cervical carcinoma had been treated with radiation therapy until 1999, when five different large clinical trials showed an overall survival benefit when chemotherapy was administered concomitantly with radiotherapy. The chemotherapy agents used in these trials were cisplatin, cisplatin combined with fluorouracil or hydroxyurea. Weekly cisplatin (40 mg/m 2 ) achieved the best responses, even when compared with the combination with fluorouracil. These results led the United States National Cancer Institute (NCI) to recommend platinum-based chemotherapy for the treatment of locally advanced cervical carcinoma. Other cytotoxic agents have been tried in combination with radiotherapy for the management of the disease, including carboplatin, paclitaxel, gemcitabine and even topotecan. Gemcitabine has shown promising results and the combination of paclitaxel and carboplatin has proved safe and effective. However, to date, there has been no agent or combination of agents to have shown superiority over weekly cisplatin. Biologic agents such as bevacizumab, cetuximab, sorafenib and erlotinib are currently being tried in different trials in combination with radiotherapy and cisplatin. Celecoxib, a COX-2 inhibitor was evaluated in an RTOG study in combination with cisplatin and flourouracil with radiation therapy with no apparent effect on DFS and poor rates of locoregional control. Chemoradiation is the current standard therapy in locally advanced cervical carcinoma. The integration of novel agents will be established by the ongoing clinical trials.
- Published
- 2008
64. Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome
- Author
-
Martín Zurdo, Sara Ortega-Cubero, Teresa Adeva-Bartolomé, Esther Cubo, Elena García-Martín, Lluisa Rubio, Margarita Arroyo-Solera, Hortensia Alonso-Navarro, Francisco Navacerrada, Marisol Calleja, Félix Javier Jiménez-Jiménez, Laura Turpín-Fenoll, Jorge Millán-Pascual, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Carmen Martínez, Pau Pastor, Esteban García-Albea, Ana Rojo-Sebastián, and José A. G. Agúndez
- Subjects
Adult ,Male ,medicine.medical_specialty ,HMOX1 ,Adolescent ,HMOX2 ,Observational Study ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Young Adult ,Risk Factors ,Restless Legs Syndrome ,Internal medicine ,mental disorders ,Genotype ,medicine ,Humans ,Copy-number variation ,Restless legs syndrome ,Allele ,Aged ,Aged, 80 and over ,biology ,business.industry ,Genetic Variation ,General Medicine ,Middle Aged ,medicine.disease ,Heme oxygenase ,Endocrinology ,biology.protein ,Female ,business ,Heme Oxygenase-1 ,Research Article - Abstract
Several neurochemical, neuropathological, neuroimaging, and experimental data, suggest that iron deficiency plays an important role in the pathophysiology of restless legs syndrome (RLS). Heme-oxygenases (HMOX) are an important defensive mechanism against oxidative stress, mainly through the degradation of heme to biliverdin, free iron, and carbon monoxide. We analyzed whether HMOX1 and HMOX2 genes are related with the risk to develop RLS. We analyzed the distribution of genotypes and allelic frequencies of the HMOX1 rs2071746, HMOX1 rs2071747, HMOX2 rs2270363, and HMOX2 rs1051308 SNPs, as well as the presence of Copy number variations (CNVs) of these genes in 205 subjects RLS and 445 healthy controls. The frequencies of rs2071746TT genotype and rs2071746T allelic variant were significantly lower in RLS patients than that in controls, although the other 3 studied SNPs did not differ between RLS patients and controls. None of the studied polymorphisms influenced the disease onset, severity of RLS, family history of RLS, serum ferritin levels, or response to dopaminergic agonist, clonazepam or GABAergic drugs. The present study suggests a weak association between HMOX1 rs2071746 polymorphism and the risk to develop RLS in the Spanish population.
- Published
- 2015
- Full Text
- View/download PDF
65. Controversial origin of Pseudomyxoma peritonei
- Author
-
Jerónimo Forteza Vila, Jose Farré Alegre, Francisco José Fernández Morejón, Antonio Brugarolas Masllorens, Pedro Bretcha Boix, and Alejandro Rojo Sebastián
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Abdominal cavity ,Appendix ,Diagnosis, Differential ,medicine ,Pseudomyxoma peritonei ,Humans ,Peritoneal Neoplasms ,Site of origin ,Aged ,Ovarian Neoplasms ,business.industry ,Ovary ,General Medicine ,medicine.disease ,Prognosis ,Pseudomyxoma Peritonei ,Adenocarcinoma, Mucinous ,medicine.anatomical_structure ,Oncology ,Appendiceal Neoplasms ,Clinicopathological features ,Female ,Peritoneum ,business - Abstract
Pseudomyxoma peritonei describes the accumulation of mucinous material in the abdominal cavity. The main diagnostic problem appears when the primary site of origin could be appendix or ovary. In this paper describe clinicopathological features and biological markers that support appendiceal origin.
- Published
- 2006
66. Neuronal nitric oxide synthase (nNOS, NOS1) rs693534 and rs7977109 variants and risk for restless legs syndrome
- Author
-
Jiménez-Jiménez, Félix Javier, primary, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán-Pascual, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Albea, Esteban, additional, García-Martín, Elena, additional, and Agúndez, José A. G., additional
- Published
- 2014
- Full Text
- View/download PDF
67. Gamma-aminobutyric acid (GABA)receptors genes polymorphisms and risk for restless legs syndrome
- Author
-
Jiménez-Jiménez, Félix, Esguevillas, Gara, Alonso-Navarro, Hortensia, Zurdo, Martín, Turpín-Fenoll, Laura, Millán-Pascual, Jorge, Adeva-Bartolomé, Teresa, Cubo, Esther, Navacerrada, Francisco, Amo, Gemma, Rojo-Sebastián, Ana, Rubio, Lluisa, Díez-Fairén, Mónica, Pastor, Pau, Calleja, Marisol, Plaza-Nieto, José, Pilo-de-la-Fuente, Belén, Arroyo-Solera, Margarita, García-Albea, Esteban, Agúndez, José, and García-Martín, Elena
- Abstract
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptors(GABR) genes rho1, 2, and 3(GABRR1, GABRR2, GABRR3), alpha4(GABRA4), epsilon(GABRE), and theta(GABRQ) with the risk of developing RLS. We studied the genotype and allelic variant frequencies of the most common SNPs in the GABRR1(rs12200969, rs1186902), GABRR2(rs282129), GABRR3(rs832032), GABRA4(rs2229940), GABRE(rs1139916), and GABRQ(rs3810651) genes in 205 RLS patients and 230 age- and gender-matched healthy controls using specific TaqMan assays. The frequencies of the GABRR3rs832032TT genotype and the allelic variant GABRR3rs832032T were significantly higher in RLS patients than in controls (odds ratio [95% confidence intervals] 7.08[1.48–46.44] and 1.66[1.16–2.37], respectively), although only the higher frequency of the rs832032T allele remained as significant after multiple comparison analysis, both in the whole series and in the female gender. The frequencies of the other genotypes of allelic variants did not differ significantly between RLS patients and controls. RLS patients carrying the GABRA4rs2229940TT genotype showed a significantly younger age at onset of RLS symptoms than those with the other two genotypes. These results suggest association between GABRR3rs832032 polymorphism and the risk for RLS, and a modifier effect of GABRA4rs2229940 on the age of onset of RLS.
- Published
- 2018
- Full Text
- View/download PDF
68. Terapias neurotróficas en modelos de parkinsonismo en oredores y primates no humanos
- Author
-
Rojo Sebastián, Ana and García de Yébenes, Justo
- Subjects
Neurociencias - Published
- 2001
69. [Comparative clinico-radiological study of lacunar infarcts of the cerebral hemispheres and brain stem in 110 cases]
- Author
-
A, Rojo-Sebastián, J L, González-Gutiérrez, J A, Egido-Herrero, and C, Fernández-Pérez
- Subjects
Cerebral Cortex ,Risk Factors ,Dysarthria ,Humans ,Cerebral Infarction ,Psychomotor Disorders ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging ,Severity of Illness Index ,Functional Laterality ,Brain Stem ,Retrospective Studies - Abstract
Lacunar infarcts (LI) are small deep infarcts due to occlusion of perforating branches.Our objective was to outline the clinical and epidemiological characteristics which differentiate hemispherical lacunar infarcts (HLI) from those of the brain stem (SLI).We present 110 cases of LI (80 HLI, 30 SLI) analysing risk factors, clinical syndromes, findings on neurological examination (dysarthria, gravity, distribution and proportional paresia), form of clinical presentation, evolution whilst in hospital, site and results of carotid duplex. Diagnosis was made in 72 patients using magnetic resonance (MR) and in 38 patients using computerized axial tomography (CT).The commonest characteristics of SLI, as compared with HLI, with statistical significance (p0.05) was the appearance of supranuclear facial paresia (OR = 2.68), severe motor involvement (OR = 4.23), form of presentation with previous TIA (OR = 6.33), fluctuating evolution of the symptoms (OR = 5.78) and progression of the paresia (OR = 6.41). Also, in the pontine LI there was significant correlation between site and gravity: the lower the site of the lesion, the more serious was the paresia. Patients with multiple LI presented with no previous risk factors significantly more frequently than those with a single LI.The different clinical profiles may help to establish the subgroups of IL, according to where they occur.
- Published
- 1999
70. The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome
- Author
-
Jiménez-Jiménez, Félix Javier, primary, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán-Pascual, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Martín, Elena, additional, and Agúndez, José A.G., additional
- Published
- 2014
- Full Text
- View/download PDF
71. Marcaje de metástasis hepática antes de quimioterapia neoadyuvante para su posterior localización y resección mediante hepatectomía no anatómica
- Author
-
Alonso Casado, Oscar, primary, González Moreno, Santiago, additional, Encinas García, Sara, additional, Rojo Sebastián, Alejandro, additional, and Olavarría Delgado, Andreina, additional
- Published
- 2013
- Full Text
- View/download PDF
72. Hepatic Metastasis Marking Before Neoadjuvant Chemotherapy for Their Subsequent Location and Resection Using Non-anatomical Hepatectomy
- Author
-
Alonso Casado, Oscar, primary, González Moreno, Santiago, additional, Encinas García, Sara, additional, Rojo Sebastián, Alejandro, additional, and Olavarría Delgado, Andreina, additional
- Published
- 2013
- Full Text
- View/download PDF
73. Dopamine receptor D3 (DRD3) gene rs6280 variant and risk for restless legs syndrome
- Author
-
Jiménez-Jiménez, Félix Javier, primary, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Agúndez, José A.G., additional, and García-Martín, Elena, additional
- Published
- 2013
- Full Text
- View/download PDF
74. Terapias neurotróficas en modelos de parkinsonismo en oredores y primates no humanos
- Author
-
García de Yébenes, Justo, Rojo Sebastián, Ana, García de Yébenes, Justo, and Rojo Sebastián, Ana
- Published
- 2006
75. MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome
- Author
-
Roco, Angela, primary, Jiménez-Jiménez, Félix Javier, additional, Alonso-Navarro, Hortensia, additional, Martínez, Carmen, additional, Zurdo, Martín, additional, Turpín-Fenoll, Laura, additional, Millán, Jorge, additional, Adeva-Bartolomé, Teresa, additional, Cubo, Esther, additional, Navacerrada, Francisco, additional, Rojo-Sebastián, Ana, additional, Rubio, Lluisa, additional, Calleja, Marisol, additional, Plaza-Nieto, José Francisco, additional, Pilo-de-la-Fuente, Belén, additional, Arroyo-Solera, Margarita, additional, García-Martín, Elena, additional, and Agúndez, José A. G., additional
- Published
- 2012
- Full Text
- View/download PDF
76. Metástasis supraclavicular en cáncer de próstata detectada con 18F-fluorocolina PET/TAC
- Author
-
Núñez Miller, R., primary, Viera, J.C., additional, Jover Díaz, R., additional, Rojo Sebastián, A., additional, Pozo, M.A., additional, and Alfonso Alfonso, J.M., additional
- Published
- 2012
- Full Text
- View/download PDF
77. Levodopa en el tratamiento de la enfermedad de Parkinson: mitos y realidades
- Author
-
Luquin Piudo, Mª Rosario, primary, García Ruiz-Espiga, Pedro José, additional, Martí, Maria Jose, additional, Rojo Sebastián, Ana, additional, Vela Desojo, Lydia, additional, Grandas Pérez, Francisco Javier, additional, Bravo Utrera, Mariano, additional, Burguera Hernández, Juan Andrés, additional, Chacón Peña, José Rafael, additional, Campos Arillo, Víctor M., additional, Durán Herrera, Carmen, additional, Fernández García, José Manuel, additional, García-Ramos García, Rocío, additional, Gómez Esteban, Juan Carlos, additional, Gutiérrez, Javier, additional, Juni Sanahuja, Juan, additional, Mata Álvarez-Santullano, Marina, additional, Martínez Castrillo, Juan Carlos, additional, Olivares Romero, Jesús, additional, Ribacoba Montero, Renée, additional, Santos García, Diego, additional, Sierra, María, additional, and Valero Merino, Caridad, additional
- Published
- 2012
- Full Text
- View/download PDF
78. Diagnóstico clínico de la enfermedad de Parkinson. ¿Cuándo pedir un estudio genético y qué hacer con esa información?
- Author
-
Rojo Sebastián, Ana, primary
- Published
- 2010
- Full Text
- View/download PDF
79. Surgical Approach to a Large Left Adrenocortical Mass with Associated Tumour Thrombosis of the Left Renal Vein: Preservation of the Ipsilateral Kidney
- Author
-
Pérez Utrilla, Manuel, primary, Nuñez Mora, Carlos, additional, Rojo Sebastián, Alejandro, additional, Cabrera Castillo, Pedro M., additional, and García Mediero, José M., additional
- Published
- 2009
- Full Text
- View/download PDF
80. Utilidad de los estudios genéticos y de neuroimagen en el diagnóstico diferencial de la enfermedad de Parkinson
- Author
-
Rojo Sebastián, Ana, primary and Corbella Sala, Cristina, additional
- Published
- 2009
- Full Text
- View/download PDF
81. Diagnóstico clínico de la enfermedad de Parkinson. ¿Cuándo pedir un estudio genético y qué hacer con esa información?
- Author
-
Ana Rojo Sebastián
- Subjects
Neurology (clinical) ,General Medicine - Published
- 2010
- Full Text
- View/download PDF
82. Creación y protocolo de seguimiento longitudinal de una cohorte multipropósito de pacientes con enfermedad de Parkinson de reciente diagnóstico: proyecto VIP
- Author
-
Linazasoro Cristóbal, Gurutz, primary, Martínez Martín, Pablo, additional, Kulisevsky Bojarsky, Jaume, additional, Aguilar Barberà, Miquel, additional, Valldeoriola Serra, Francesc, additional, Rojo Sebastián, Ana, additional, Van Blercom, Nadege, additional, Vela Desojo, Lydia, additional, Bergaretxe, AA.VV., additional, Luquin Piudo, Mª Rosario, additional, Castro García, Alfonso, additional, Sesar Ignacio, Ángel, additional, Menéndez Guisasola, Luis, additional, Salvador Aguiar, Carlos, additional, Blázquez Estrada, Marta, additional, González, S., additional, Fernández, J.M., additional, López del Val, Luis Javier, additional, Miquel Rodríguez, Francesc, additional, Bayés Rusiñol, Mª. Angels, additional, Burguera Hernández, Juan Andrés, additional, Chacón Peña, José Rafael, additional, Durán Herrera, Carmen, additional, Martínez Castrillo, Juan Carlos, additional, García Ruiz-Espiga, Pedro José, additional, Duarte García-Luis, Jacinto, additional, Mendoza, AA.VV., additional, Rodriguez, AA.VV., additional, Vivancos Matellano, Francisco, additional, Pondal, Margarita, additional, Vaamonde Gamo, Julia, additional, Benito León, Julián, additional, Campos Arillo, Víctor M., additional, García Muñozguren, Susana, additional, Catalán Alonso, Mª José, additional, Palomino García, Alfredo, additional, Mir Rivera, Pablo, additional, Carballo Cordero, Manuel, additional, Mínguez Castellanos, Adolfo, additional, Ortega Moreno, Ángel, additional, Leiva Santana, Carlos, additional, Álvarez Saúco, María, additional, Posada Rodríguez, Ignacio Javier, additional, Balseiro Gómez, José Jesús, additional, Cubo Delgado, Esther, additional, Frades Payo, Belén, additional, Forjaz, Maria Joao, additional, and Arroyo Velasco, Susana, additional
- Published
- 2006
- Full Text
- View/download PDF
83. Estudio piloto sobre una medida específica para los trastornos del sueño de la enfermedad de Parkinson: SCOPA-Sueño
- Author
-
Martínez Martín, Pablo, primary, Cubo Delgado, Esther, additional, Aguilar Barberà, Miquel, additional, Bergareche, Alberto, additional, Escalante Arroyo, Sonia, additional, Rojo Sebastián, Ana, additional, Campdelacreu, Jaume, additional, Frades Payo, Belén, additional, Arroyo Velasco, Susana, additional, Menéndez Guisasola, Luis, additional, Grupo ELEP, AA.VV., additional, Salvador Aguiar, Carlos, additional, González González, S., additional, Bayés Rusiñol, Mª. Angels, additional, Valldeoriola Serra, Francesc, additional, Vela Desojo, Lydia, additional, Benito León, Julián, additional, Vivancos Matellano, Francisco, additional, Catalán Alonso, Mª José, additional, García Muñozguren, Susana, additional, Durán Herrera, Carmen, additional, Duarte García-Luis, Jacinto, additional, Martínez Castrillo, Juan Carlos, additional, Mendoza Rodríguez, Amelia, additional, Rodríguez Sanz, Mª Fernanda, additional, López del Val, Luis Javier, additional, Chacón Peña, José Rafael, additional, Carballo Cordero, Manuel, additional, Fernández García, José Manuel, additional, Campos Arillo, Víctor M., additional, Álvarez Saúco, María, additional, Leiva Santana, Carlos, additional, Castro García, Alfonso, additional, Sesar Ignacio, Ángel, additional, Ortega Moreno, Ángel, additional, and Luquin Piudo, Mª Rosario, additional
- Published
- 2006
- Full Text
- View/download PDF
84. Estudio longitudinal de pacientes con enfermedad de Parkinson (ELEP): objetivos y metodología
- Author
-
Grupo ELEP, AA.VV., primary, Martínez Martín, Pablo, additional, Linazasoro Cristóbal, Gurutz, additional, Kulisevsky Bojarsky, Jaume, additional, Aguilar Barberà, Miquel, additional, de Pedro Cuesta, Jesús, additional, Cubo Delgado, Esther, additional, Forjaz, Maria Joao, additional, Bergareche, Alberto, additional, Martínez Castrillo, Juan Carlos, additional, Blázquez Estrada, Marta, additional, Menéndez Guisasola, Luis, additional, Salvador Aguiar, Carlos, additional, González González, S., additional, Bayés Rusiñol, Mª. Angels, additional, Vela Desojo, Lydia, additional, Balseiro Gómez, José Jesús, additional, Ortega Moreno, Ángel, additional, García Muñozguren, Susana, additional, Frades Payo, Belén, additional, Arroyo Velasco, Susana, additional, Durán Herrera, Carmen, additional, Duarte García-Luis, Jacinto, additional, Mendoza Rodríguez, Amelia, additional, Rodríguez Sanz, Mª Fernanda, additional, López del Val, Luis Javier, additional, Chacón Peña, José Rafael, additional, Fernández García, José Manuel, additional, Benito León, Julián, additional, Campos Arillo, Víctor M., additional, Vivancos Matellano, Francisco, additional, Rojo Sebastián, Ana, additional, Álvarez Saúco, María, additional, Leiva Santana, Carlos, additional, Mir Rivera, Pablo, additional, Carballo Cordero, Manuel, additional, Palomino García, Alfredo, additional, Burguera Hernández, Juan Andrés, additional, Catalán Alonso, Mª José, additional, and Luquin Piudo, Mª Rosario, additional
- Published
- 2006
- Full Text
- View/download PDF
85. Estudio longitudinal de pacientes con enfermedad de Parkinson (ELEP): objetivos y metodología
- Author
-
Pablo Martínez Martín, Lydia Vela Desojo, Luis Javier López del Val, Mª Rosario Luquin Piudo, Jacinto Duarte García-Luis, Mª José Catalán Alonso, Miquel Aguilar Barberá, María Álvarez Sauco, Amelia Mendoza Rodríguez, S. González González, Francisco Vivancos Matellano, Víctor Campos Arillo, Aa.Vv. Grupo Elep, José Manuel Fernández García, Susana García Muñozguren, Carmen Durán Herrera, Mª. Angels Bayés Rusiñol, Jaume Kulisevsky Bojarsky, Esther Cubo Delgado, Gurutz Linazasoro Cristobal, Ana Rojo Sebastián, Luis Menéndez Guisasola, Mª Fernanda Rodríguez Sanz, Jesús de Pedro Cuesta, Maria João Forjaz, Angel Ortega Moreno, Juan Carlos Martínez Castrillo, Belén Frades Payo, Alberto Bergareche, Alfredo Palomino García, Manuel Carballo Cordero, José Jesús Balseiro Gómez, Marta Blázquez Estrada, José Rafael Chacón Peña, Carlos Leiva Santana, Julián Benito León, Pablo Mir Rivera, Juan Andrés Burguera Hernández, Susana Arroyo Velasco, and Carlos Salvador Aguiar
- Subjects
Health related quality of life ,Selection bias ,medicine.medical_specialty ,Longitudinal study ,business.industry ,media_common.quotation_subject ,General Medicine ,Disease ,Physical medicine and rehabilitation ,Progressive disorder ,medicine ,Neurology (clinical) ,business ,media_common - Abstract
Introduction and development. Parkinson's disease (PD) is a chronic and progressive disorder. It produces a significant burden not only for patients, but also for their family and caregivers, with a major socio-economic impact on society. Current knowledge on PD is characterized by scarce information about the evolutionary course of: 1) the non-motor PD features; 2) impact of non-motor PD features on disability and health related quality of life (HRQL) impairment; 3) factors related to disability and HRQL determinants; 4) factors that speed or slow the progression of PD; 5) differential long-term effect of available PD therapeutic schedules and their relationships with disability, complications, and HRQL; and 6) impact of the disease on patients' caregivers. In addition, heterogeneity in the metric quality of the applied measures and selection bias are frequently found. Conclusion. Due to the aforementioned limitations and from a multidimensional perspective, a new longitudinal study in PD is deemed necessary. The longitudinal study of PD patients (ELEP) includes a long-term follow-up of never before sistematically assessed aspects, will allow to increase the global knowledge about PD.
- Published
- 2006
- Full Text
- View/download PDF
86. Estudio piloto sobre una medida específica para los trastornos del sueño de la enfermedad de Parkinson: SCOPA-Sueño
- Author
-
Pablo Martínez Martín, Esther Cubo Delgado, Miquel Aguilar Barberà, Alberto Bergareche, Sonia Escalante Arroyo, Ana Rojo Sebastián, Jaume Campdelacreu, Belén Frades Payo, Susana Arroyo Velasco, Luis Menéndez Guisasola, AA.VV. Grupo ELEP, Carlos Salvador Aguiar, S. González González, Mª. Angels Bayés Rusiñol, Francesc Valldeoriola Serra, Lydia Vela Desojo, Julián Benito León, Francisco Vivancos Matellano, Mª José Catalán Alonso, Susana García Muñozguren, Carmen Durán Herrera, Jacinto Duarte García-Luis, Juan Carlos Martínez Castrillo, Amelia Mendoza Rodríguez, Mª Fernanda Rodríguez Sanz, Luis Javier López del Val, José Rafael Chacón Peña, Manuel Carballo Cordero, José Manuel Fernández García, Víctor M. Campos Arillo, María Álvarez Saúco, Carlos Leiva Santana, Alfonso Castro García, Ángel Sesar Ignacio, Ángel Ortega Moreno, and Mª Rosario Luquin Piudo
- Subjects
Gynecology ,medicine.medical_specialty ,Multicenter study ,business.industry ,Medicine ,Neurology (clinical) ,General Medicine ,Scopa ,business - Abstract
Introduccion. En la enfermedad de Parkinson (EP) existe una alta prevalencia de trastornos del sueno. Objetivos. Comprobar los atributos metricos basicos de la escala SCOPA-sueno para pacientes con EP; objetivo secundario: analizar el impacto del trastorno del sueno en la calidad de vida relacionada con la salud (CVRS) del paciente y de su cuidador principal. Sujetos y metodos. 68 pacientes con EP y sus cuidadores principales. Se aplicaron: Hoehn y Yahr, SCOPA-motor, impresion clinica de gravedad (CISI-PD), escala PDSS, Hospital Anxiety and Depression Scale, SCOPA-psicosocial y EuroQoL. El cuidador cumplimento un cuestionario PDSS sobre el sueno del paciente y las medidas de la CVRS (SF-36, EuroQoL). Se analizaron la aceptabilidad, las asunciones escalares, la consistencia interna, la validez de constructo y la precision de la SCOPA-sueno. Resultados. La SCOPA-sueno mostro aceptabilidad satisfactoria y asunciones escalares. La subescala sueno nocturno (SC-Sn) presento leve efecto techo (22,1%), y la subescala somnolencia diurna (SC-Sd), defectuosa validez convergente del item 6; la consistencia interna de ambas resulto satisfactoria (alfa = 0,84 y 0,75, respectivamente). SC-Sn correlaciono significativamente con la PDSS (rS = ?0,70) y con el cuestionario PDSS cumplimentado por el cuidador (rS = ?0,53), y fueron menores los valores respectivos para la SC-Sd (rS = ?0,41 y ?0,50). Error estandar de la medida: SC-Sn, 1,45; SC-Sd, 1,76. La CVRS del paciente y la del cuidador mostraron una escasa correlacion con las medidas de sueno. Conclusiones. La escala SCOPA-sueno es viable, consistente y util para evaluar el trastorno del sueno en pacientes con EP. La relacion entre la CVRS y la alteracion del sueno fue debil.
- Published
- 2006
- Full Text
- View/download PDF
87. Creación y protocolo de seguimiento longitudinal de una cohorte multipropósito de pacientes con enfermedad de Parkinson de reciente diagnóstico: proyecto VIP
- Author
-
Gurutz Linazasoro Cristóbal, Pablo Martínez Martín, Jaume Kulisevsky Bojarsky, Miquel Aguilar Barberà, Francesc Valldeoriola Serra, Ana Rojo Sebastián, Nadege Van Blercom, Lydia Vela Desojo, AA.VV. Bergaretxe, Mª Rosario Luquin Piudo, Alfonso Castro García, Ángel Sesar Ignacio, Luis Menéndez Guisasola, Carlos Salvador Aguiar, Marta Blázquez Estrada, S. González, J.M. Fernández, Luis Javier López del Val, Francesc Miquel Rodríguez, Mª. Angels Bayés Rusiñol, Juan Andrés Burguera Hernández, José Rafael Chacón Peña, Carmen Durán Herrera, Juan Carlos Martínez Castrillo, Pedro José García Ruiz-Espiga, Jacinto Duarte García-Luis, AA.VV. Mendoza, AA.VV. Rodriguez, Francisco Vivancos Matellano, Margarita Pondal, Julia Vaamonde Gamo, Julián Benito León, Víctor M. Campos Arillo, Susana García Muñozguren, Mª José Catalán Alonso, Alfredo Palomino García, Pablo Mir Rivera, Manuel Carballo Cordero, Adolfo Mínguez Castellanos, Ángel Ortega Moreno, Carlos Leiva Santana, María Álvarez Saúco, Ignacio Javier Posada Rodríguez, José Jesús Balseiro Gómez, Esther Cubo Delgado, Belén Frades Payo, Maria Joao Forjaz, and Susana Arroyo Velasco
- Subjects
Neurology (clinical) ,General Medicine - Abstract
Introduccion. La enfermedad de Parkinson (EP) es una enfermedad neurodegenerativa muy heterogenea desde el punto de vista etiologico, clinico y terapeutico, lo que dificulta la interpretacion de resultados de estudios transversales. Son necesarios los registros de pacientes y los estudios longitudinales de cohortes bien caracterizadas desde el punto de vista clinico y terapeutico. Objetivo. Creacion de una cohorte multiproposito compuesta de 300 pacientes con EP de reciente diagnostico y no tratados, para su evaluacion y tratamiento de un modo uniforme y protocolizado. Esta cohorte se seguira de manera longitudinal y el proyecto finalizara con la donacion del cerebro. Desarrollo. Se trata de un proyecto non-hypothesis driven cuyos pasos inmediatos son: a) Inclusion de pacientes con EP de reciente diagnostico y no tratados; b) Protocolizacion de las evaluaciones (clinicas y pruebas complementarias) y recomendaciones de tratamiento; c) Obtencion y conservacion de muestras biologicas; d) Elaboracion de una base de datos e implementacion en la red; e) Diseno y puesta en marcha de diferentes estudios de modo simultaneo; y f) Donacion de cerebro. El proyecto sera llevado a cabo por el Consorcio Parkinson en todo el pais. Los estudios a realizar en el futuro, de manera prospectiva y retrospectiva, son de diversa indole (clinicos, geneticos, de neuroimagen, moleculares...).
- Published
- 2006
- Full Text
- View/download PDF
88. El medio condicionado de glía protege de la toxicidad inducida in vivo con 6-OH-dopamina
- Author
-
Rojo Sebastián, Ana, primary, Mena Gómez, Mª Ángeles, additional, Blázquez, A., additional, Casarejos Fernández, M. J., additional, Fontán Barreiro, A., additional, and García de Yébenes Prous, Justo, additional
- Published
- 2002
- Full Text
- View/download PDF
89. Estudio clinicorradiológico comparativo entre infartos lacunares hemisféricos y de tronco cerebral en 110 casos
- Author
-
Rojo Sebastián, Ana, primary, González Gutiérrez, José Luis, additional, Egido Herrero, José Antonio, additional, and Fernández Pérez, Cristina, additional
- Published
- 1999
- Full Text
- View/download PDF
90. Neuroimagen en la hipoglucemia
- Author
-
Cubo Delgado, Esther, primary, Andrés del Barrio, María del Templo, additional, Rojo Sebastián, Ana, additional, Guerrero Solá, Antonio, additional, Urra, D.G., additional, and Méndez, R., additional
- Published
- 1998
- Full Text
- View/download PDF
91. Estudio clinicorradiológico comparativo entre infartos lacunares hemisféricos y de tronco cerebral en 110 casos
- Author
-
Fernández-Pérez C, Egido-Herrero Ja, Rojo-Sebastián A, and González-Gutiérrez Jl
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Neurological examination ,Magnetic resonance imaging ,General Medicine ,Lesion ,Dysarthria ,Statistical significance ,Radiological weapon ,Epidemiology ,Occlusion ,medicine ,Neurology (clinical) ,Radiology ,medicine.symptom ,business - Abstract
INTRODUCTION Lacunar infarcts (LI) are small deep infarcts due to occlusion of perforating branches. OBJECTIVE Our objective was to outline the clinical and epidemiological characteristics which differentiate hemispherical lacunar infarcts (HLI) from those of the brain stem (SLI). PATIENTS AND METHODS We present 110 cases of LI (80 HLI, 30 SLI) analysing risk factors, clinical syndromes, findings on neurological examination (dysarthria, gravity, distribution and proportional paresia), form of clinical presentation, evolution whilst in hospital, site and results of carotid duplex. Diagnosis was made in 72 patients using magnetic resonance (MR) and in 38 patients using computerized axial tomography (CT). RESULTS The commonest characteristics of SLI, as compared with HLI, with statistical significance (p < 0.05) was the appearance of supranuclear facial paresia (OR = 2.68), severe motor involvement (OR = 4.23), form of presentation with previous TIA (OR = 6.33), fluctuating evolution of the symptoms (OR = 5.78) and progression of the paresia (OR = 6.41). Also, in the pontine LI there was significant correlation between site and gravity: the lower the site of the lesion, the more serious was the paresia. Patients with multiple LI presented with no previous risk factors significantly more frequently than those with a single LI. CONCLUSION The different clinical profiles may help to establish the subgroups of IL, according to where they occur.
- Published
- 1999
- Full Text
- View/download PDF
92. Surgical approach to a large left adrenocortical mass with associated tumour thrombosis of the left renal vein: preservation of the ipsilateral kidney.
- Author
-
Utrilla, Manuel Pérez, Mora, Carlos Nuñez, Sebastián, Alejandro Rojo, Castillo, Pedro M. Cabrera, Castillo, Jose M. Cabrera, Mediero, José M. García, Pérez Utrilla, Manuel, Nuñez Mora, Carlos, Rojo Sebastián, Alejandro, Cabrera Castillo, Pedro M, and García Mediero, José M
- Subjects
KIDNEY tumors ,THROMBOSIS ,VENA cava inferior ,ELECTIVE surgery ,ADRENALECTOMY ,SURGICAL excision ,CISPLATIN ,ALKALINE phosphatase ,THROMBOSIS surgery ,KIDNEYS ,MAGNETIC resonance imaging - Abstract
A sixty-years-old male with diagnosis of a left adrenal mass (146 x 99 x 126 mm) with associated tumour thrombosis of the left renal vein with no clear signs of thrombosis of the inferior vena cava was admitted for elective surgery Finally an adrenalectomy and excision of tumour thrombus preserving the ipsilateral kidney was made. Despite of the complex vascular management, this kind of approaches allow to preserve normal renal function in patients with future nephrotoxic treatment like cisplatin. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
93. Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome
- Author
-
Fj, Jiménez-Jiménez, García-Martín E, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Jf, Plaza-Nieto, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, and José Agundez
94. Controversial origin of Pseudomyxoma peritonei.
- Author
-
Rojo Sebastián A, Fernández Morejón FJ, Bretcha Boix P, Farré Alegre J, Forteza Vila J, and Brugarolas Masllorens A
- Subjects
- Adenocarcinoma, Mucinous diagnosis, Adenocarcinoma, Mucinous surgery, Aged, Appendiceal Neoplasms diagnosis, Appendiceal Neoplasms surgery, Appendix pathology, Diagnosis, Differential, Female, Humans, Ovarian Neoplasms diagnosis, Ovarian Neoplasms surgery, Ovary pathology, Peritoneal Neoplasms diagnosis, Peritoneal Neoplasms pathology, Peritoneal Neoplasms surgery, Peritoneum pathology, Prognosis, Pseudomyxoma Peritonei diagnosis, Pseudomyxoma Peritonei pathology, Pseudomyxoma Peritonei surgery, Adenocarcinoma, Mucinous pathology, Appendiceal Neoplasms pathology, Ovarian Neoplasms pathology, Peritoneal Neoplasms etiology, Pseudomyxoma Peritonei etiology
- Abstract
Pseudomyxoma peritonei describes the accumulation of mucinous material in the abdominal cavity. The main diagnostic problem appears when the primary site of origin could be appendix or ovary. In this paper describe clinicopathological features and biological markers that support appendiceal origin.
- Published
- 2006
- Full Text
- View/download PDF
95. [Comparative clinico-radiological study of lacunar infarcts of the cerebral hemispheres and brain stem in 110 cases].
- Author
-
Rojo-Sebastián A, González-Gutiérrez JL, Egido-Herrero JA, and Fernández-Pérez C
- Subjects
- Brain Stem blood supply, Cerebral Cortex blood supply, Cerebral Infarction complications, Dysarthria etiology, Humans, Magnetic Resonance Imaging, Psychomotor Disorders etiology, Retrospective Studies, Risk Factors, Severity of Illness Index, Tomography, X-Ray Computed, Brain Stem diagnostic imaging, Brain Stem pathology, Cerebral Cortex diagnostic imaging, Cerebral Cortex pathology, Cerebral Infarction diagnosis, Functional Laterality
- Abstract
Introduction: Lacunar infarcts (LI) are small deep infarcts due to occlusion of perforating branches., Objective: Our objective was to outline the clinical and epidemiological characteristics which differentiate hemispherical lacunar infarcts (HLI) from those of the brain stem (SLI)., Patients and Methods: We present 110 cases of LI (80 HLI, 30 SLI) analysing risk factors, clinical syndromes, findings on neurological examination (dysarthria, gravity, distribution and proportional paresia), form of clinical presentation, evolution whilst in hospital, site and results of carotid duplex. Diagnosis was made in 72 patients using magnetic resonance (MR) and in 38 patients using computerized axial tomography (CT)., Results: The commonest characteristics of SLI, as compared with HLI, with statistical significance (p < 0.05) was the appearance of supranuclear facial paresia (OR = 2.68), severe motor involvement (OR = 4.23), form of presentation with previous TIA (OR = 6.33), fluctuating evolution of the symptoms (OR = 5.78) and progression of the paresia (OR = 6.41). Also, in the pontine LI there was significant correlation between site and gravity: the lower the site of the lesion, the more serious was the paresia. Patients with multiple LI presented with no previous risk factors significantly more frequently than those with a single LI., Conclusion: The different clinical profiles may help to establish the subgroups of IL, according to where they occur.
- Published
- 1999
96. [Anticoagulation in auricular fibrillation].
- Author
-
Rojo Sebastián A, Egido Herrero JA, González Gutiérrez JL, and Andrés del Barrio MT
- Subjects
- Aged, Clinical Protocols, Humans, Anticoagulants therapeutic use, Atrial Fibrillation drug therapy
- Published
- 1995
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.