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BackgroundLimited digital literacy is a barrier for vulnerable patients accessing health care. ObjectiveThe Stanford Technology Access Resource Team (START), a service-learning course created to bridge the telehealth digital divide, trained undergraduate and graduate students to provide hands-on patient support to improve access to electronic medical records (EMRs) and video visits while learning about social determinants of health. MethodsSTART students reached out to 1185 patients (n=711, 60% from primary care clinics of a large academic medical center and n=474, 40% from a federally qualified health center). Registries consisted of patients without an EMR account (at primary care clinics) or patients with a scheduled telehealth visit (at a federally qualified health center). Patient outcomes were evaluated by successful EMR enrollments and video visit setups. Student outcomes were assessed by reflections coded for thematic content. ResultsOver 6 academic quarters, 57 students reached out to 1185 registry patients. Of the 229 patients contacted, 141 desired technical support. START students successfully established EMR accounts and set up video visits for 78.7% (111/141) of patients. After program completion, we reached out to 13.5% (19/141) of patients to collect perspectives on program utility. The majority (18/19, 94.7%) reported that START students were helpful, and 73.7% (14/19) reported that they had successfully connected with their health care provider in a digital visit. Inability to establish access included a lack of Wi-Fi or device access, the absence of an interpreter, and a disability that precluded the use of video visits. Qualitative analysis of student reflections showed an impact on future career goals and improved awareness of health disparities of technology access. ConclusionsOf the patients who desired telehealth access, START improved access for 78.7% (111/141) of patients. Students found that START broadened their understanding of health disparities and social determinants of health and influenced their future career goals.

Riset ini bertujuan buat mendeskripsikan keefektivan metode suku kata terhadap siswa kelas rendah yang bersumber pada kenyataan dilapangan masih banyak siswa yang membaca mengeja. Oleh sebab itu, 2 pelaksanaan tata cara suku kata ini efisien digunakan buat siswa supaya membaca mudah tanpa mengeja. Riset ini memakai tata cara riset kualitatif dengan tipe riset studi literatur. Hasil dari riset ini merupakan metode suku kata bisa tingkatkan keahlian membaca spesialnya membaca permulaan pada siswa kelas rendah. Perihal tersebut bisa dilihat dari kenaikan keahlian membaca siswa. Perihal tersebut pula tidak terlepas dari kedudukan orang tua di rumah yang wajib senantiasa mendampingi anaknya buat belajar membaca. Ada kelebihan serta kekurangan pada pelaksanaan tata cara suku kata dalam pendidikan membaca permulaan. Kelebihan dari tata cara suku kata ini merupakan siswa bisa membaca dengan mudah tanpa wajib mengeja terlebih dulu, perihal ini sangat menolong siswa terlebih pada dikala pendidikan di kelas. Sebaliknya kekurangan pada tata cara ini merupakan siswa belum mudah membaca ataupun kesusahan bila membaca teks yang terdapat huruf tunggal di akhir ataupun“ ng”. Supaya tata cara suku kata ini tercapai cocok yang diharapkan lebih baik guru memetakan keahlian membaca dini siswa setelah itu guru pula mengkomunikasikan dengan orang tua, perihal ini diharapkan apa yang telah dibelajarkan di sekolah bisa dilanjutkan di rumah guna tingkatkan pendidikan membaca permulaan siswa.

This study aims to analyze the use of conceptual metaphors in a collection of Acehnese folk song lyrics using a cognitive semantic approach. Employing a qualitative method, the research focuses on cognitive semantic analysis to explore and understand the meanings embedded in Acehnese folk song lyrics with depth and precision. The sample collection involves selecting a diverse set of Acehnese folk song lyrics performed by Rafli Kande, including Aneuk Yatim, Wasiet Keu Aneuk, and Jasa Poma, which represent a variety of themes, genres, and time periods. The technique employed is text analysis, which examines song lyrics in depth to identify conceptual metaphors based on their types, such as ontological, structural, or orientational metaphors. The study identifies key metaphors in Acehnese folk songs, reflecting cultural values like familial bonds, social hierarchies, and spiritual beliefs. These metaphors illustrate the interconnectedness of nature and human life, emphasizing reverence for the environment and the cyclical nature of existence. Overall, Acehnese folk songs serve to preserve cultural heritage, reinforce collective identity, and provide moral guidance, showcasing their significance in Acehnese society.

Sumatera Barat yang merupakan salah satu Provinsi di Indonesia yang memiliki potensi kekayaan budaya dan pemandangan alam yang indah, juga memiliki sektor pertanian yang memberikan kontribusi besar terhadap Pendapatan Domestik Regional Bruto daerah termasuk Kabupaten Solok Selatan dengan Kawasan Seribu Rumah Gadang sebagai ikon pariwisata daerahnya. Kawasan konservasi Danau Bontak merupakan satu-satunya Danau yang ada di Kabupaten Solok Selatan yang terletak di wilayah konservasi Taman Nasional Kerinci Seblat (TNKS) yang merupakan salah satu gerbang pendakian Gunung Kerinci. Kelompok masyarakat Konservasi Mandiri (KKM) Bangun Rejo telah melakukan upaya pengelolaan agroekowisata dengan membentuk kelompok sadar wisata (Pokdarwis) dan kelompok tani yang memiliki bentuk usaha berupa perkebunan, pertanian, dan peternakan yang terintegrasi dengan wisata alam Danau Bontak. Tujuan dilakukannya kegiatan pemberdayaan terhadap kelompok masyarakat ini dilaksanakan sebagai bentuk upaya pengembangan agroekowisata berkelanjutan di Kabupaten Solok Selatan. Untuk mendukung pengembangan wisata ke kawasan ini, pemberdayaan masyarakat dilakukan dengan metode kegiatan Focus Group Discussion (FGD) untuk mengidentifikasi potensi pengembangan agroekowisata danau bontak. Dari hasil kegiatan ini diperoleh gambaran pengembangan dengan konsep agroeduwisata, dibuatnya akun media sosial sebagai media promosi serta pembersihan dan pemasangan jalur tracking petunjuk aktivitas wisata pada Kawasan Danau Bontak. Selain itu dilakukan juga edukasi terkait dengan pelaksanaan wisata yang mengutamakan pelestarian keanekaragaman hayati yang ada dalam kawasan konservasi untuk menunjang keberlanjutan pengetahuan terhadap keanekaragaman lingkungan di sekitar kawasan Danau Bontak. Dengan demikian diharapkan kawasan ini dapat menarik bagi wisatawan lokal tetapi juga bagi wisatawan asing, khususnya para mahasiswa dan peneliti yang tertarik untuk mengeksplorasi potensi flora dan fauna dengan konsep agroeduwisata.

β-Casomorphin-7 (BCM), a breakdown product of milk β-casein, exhibits opioid activity. Opioids are known to affect the immune system, but the effects of BCM on ulcerative colitis (UC) are not clear. We examined the effects of BCM on mucosal immunity using a mouse dextran sulfate sodium-induced colitis model and an in vitro CD8+ T cell activation model. Human UC patients were examined to reveal the relationship between CD10 and mucosal immunity. Combined treatment of the colitis model with thiorphan (TOP) inhibited BCM degradation by suppressing CD10 in the intestinal mucosa, activating mouse mucosal CD8, and suppressing CD4 and Treg. In the CD8+ T cell in vitro activation assay using mouse splenocytes, BCM inhibited the oxidative phosphorylation (OXPHOS) of CD8+ T cells and induced the glycolytic pathway, promoting their activation. Conversely, in a culture system, BCM suppressed OXPHOS and decreased defensin α production in IEC6 mouse intestinal epithelial cells. In the mouse model, BCM reduced defensin α and butyrate levels in the colonic mucosa. During the active phase of human ulcerative colitis, the downward regulation of ileal CD10 expression by CpG methylation of the gene promoter was observed, resulting in increased CD8 activation and decreased defensin α and butyrate levels. BCM is a potential aggravating factor for UC and should be considered in the design of dietary therapy. In addition, decreased CD10 expression may serve as an indicator of UC activity and recurrence, but further clinical studies are needed.

Smoking behavior is a significant risk factor causing heart and blood vessel disorders and resulting in high mortality rates. It is essential to stop this behavior as an effort to prevent and control risk factors, break the chain of nicotine addiction, and reduce the prevalence of heart and blood vessel disease. This study aimed to improve the knowledge and attitudes of smoking cessation in active smokers. The coaching clinic using smoking effect video learning for nine active smokers in RT 02 RW 06 Pasar Ambacang, Padang, West Sumatra, Indonesia. A smoking cessation questionnaire was used to measure attitudes of respondents. The results found a significant increase in smoking cessation scores from 18 to 22 after participating in education. Video-based education is effective for increasing knowledge and motivating smokers to want to stop smoking. Continuous education and assistance are needed to increase the implementation of smoking cessation in the community.

Blended learning is learning that is a mixture of online and offline in class that must improve with innovation. Blended learning can be implemented using various learning tools that are integrated with learning models, one of which is the case-based learning model. This research aims to develop student worksheets for blended learning (SW-Blend) based on the case-based learning model. The method used in this research is research and development (R&D) with an approach using the ADDIE development stages. The implementation of this research will be in future research. The results of this research are that according to the results of the initial analysis, 90% of respondents have used a learning management system, 38.57% have not used problem-based student worksheets, and 42.57% still rarely use case-based learning. The validation results of the SW-Blend that have been developed are categorized as very valid so they are suitable for use in learning. Learning using blended learning is very important to be implemented using learning tools, in this case, SW-Blend based on case-based learning to improve students' critical thinking skills.

Orchid flowers are believed to be an antioxidant source, however, the antioxidant activity of the Cymbidium Golden Boy (CGB) orchid has not been identified. The antioxidant potential can be applied to flower leather products, and a main reason behind the idea is the valorization of agricultural waste. The aim of this research is to study phenol content and antioxidant capacity of ethanol extracts of CGB orchid petals. Additionally, this study aimed to determine the best formulation for flower leather products with a combination of carrageenan and gum arabic based on organoleptic acceptance. This research was conducted by extracting CGB orchid flowers using ethanol, and total phenol and antioxidant activity of the extracts were determined. Moreover, the flower leather products were mad from CGB orchid flowers as the raw material, accroding to a Factorial Randomized Block Design using two factors as follows: carrageenan concentration (0, 0.3, 0.5, and 0.7%) and gum arabic concentration (0.9, 1.2, and 1.5%). Flower leather samples were analyzed for moisture content, tensile strength, total dissolved solid, color intensity, and sensory. The ethanol extract of CGB orchid flowers showed antioxidant capacity up to 23.88 ppm and high phenolic content which is equal to 15.32 mg GAE/g. The differences between carrageenan and arabic gum concentration showed significant effect on water content and dissolve solid, but they did not affect on tensile strength and color intensity. The best treatment of flower leather according to panelist evaluation was those prepared from carrageenan 0.5% and arabic gum 0.9%, reaching tensile strength 4.86 N, brightness level (L) 40.1, (a+) +5.7, (+b) 23.7, water content 19.18%, aroma score 3.76 (slight flowery), taste 4.84 (pleasant), and texture 4.56 (approaching chewiness).

Abstract Aim Behavioral psychological symptoms of dementia (BPSD) are sometimes difficult to treat due to severe psychiatric symptoms such as delusions of poisoning and violent behavior. Moreover, in cases of parental neglect, the management of these psychiatric symptoms becomes more difficult. Therefore, home‐visiting doctors sometimes have to manage patients with BPSD and severe psychiatric symptoms, and a new approach is needed. In this case report, the effect of blonanserin transdermal patch on these patients is to be highlighted. Methods The patient is a 91‐year‐old woman diagnosed with Alzheimer's disease. She had severe BPSD such as delusion of robbery and violent behavior, and refused oral medications including memantine and yokukansan. Then she was treated with blonanserin transdermal patch (20 mg/day). The severity of psychiatric symptoms of BPSD was assessed over time using the Neuropsychiatric Inventory (NPI) score. Moreover, the patient's cognitive function was also assessed over time by Mini‐Mental State Examination (MMSE). Results After the introduction of blonanserin patch, the patient's psychiatric symptoms were stabilized markedly, and both NPI and MMSE scores improved. The patient was able to stay at home calmly and was mentally well stabilized to the extent that she did not require hospitalization. No apparent side effects were admitted. Conclusions The blonanserin transdermal patch may be able to manage BPSD at home and is effective in patients who refuse oral medications. Home‐visiting doctors may consider the use of blonanserin patches at home for patients with severe BPSD, manifesting as delusions of poisoning and refusing oral drugs.

We report 3 patients with recurrences after stent-graft placement for arterio-visceral/arterio-luminal fistulas in long-term follow-up. Two patients had ureteroarterial fistulas and the other had a tracheo-innominate artery fistula. All 3 patients had hemorrhage on initial presentation and underwent a stent-graft placement for an arterio-visceral/arterio-luminal fistula. Recurrences occurred over a period of 8-26 months and were diagnosed by contrast-enhanced computed tomography; pseudoaneurysms were found in contrast-enhanced computed tomography images in all cases. Pseudoaneurysms may be noted on contrast-enhanced computed tomography as the only finding of recurrences during long-term follow-up after stent-graft placement for arterio-visceral/arterio-luminal fistulas.

Research aims: This study aims to examine how gender will differentiate the effect of cost information and management control system adoption during the New Product Development (NPD) process. The importance of such research lies in the suggested development of gender-diverse teams to achieve optimum performance. Design/Methodology/Approach: An experimental design was employed to test proposed hypotheses. Data from 117 Accounting undergraduate students as surrogates of professional NPD designers were analyzed using Analysis of Covariance (ANCOVA). Research findings: Results revealed that female designers, due to comprehensive processing and stereotype threat, achieved more cost-effective designs with specific information and diagnostic control systems. In comparison, males would achieve better performance using relative information and designing in interactive control since they tended to be heuristic and free from stereotyping. Theoretical contribution/Originality: This research confirms gender differences in NPD. The explanation using the selectivity hypothesis and task bind mechanism contributes to the literature by supporting clear causal relationships in gender-related NPD contexts. Practitioner/Policy implication: In NPD, management should consider the proper presentation of information across specific users, including across teams with gender variability. Further, the design of the management control system should consider variability once the gender-diverse team has been developed. Research limitation/Implication: The causal relationship in this study was limited to a specific experimental setting, which did not reflect all complexities in practice. However, the interplay between variables under study leads to the avenue for future research to broaden the test into different metrics of NPD performance, types of information, and possible designer variability.

Background: Most of the incidence of hypoglycemia in hospital (11.29%) is caused by administering insulin therapy as a therapeutic modality in diabetes mellitus patients during hospitalization. The bond between albumin and insulin using the help of fatty acids makes insulin control the body's glycemic levels. Aim: The purpose of this study was to determine and analyze the correlation between albumin levels and glucose levels in hypoglycemia patients after the administration of insulin therapy at the Ratu Zalecha General Hospital. Methods: This study was an analytic observational study with a cross-sectional approach. A total of 32 samples were obtained by purposive sampling Results: The patient's mean glucose level was 48.95 ± 11.5 mg/dL and the patient's mean albumin level was 2.4 ± 0.6 g/dL. Bivariate analysis using Pearson's correlation test showed a correlation between albumin levels and glucose levels (p = 0.045

Tingginya jumlah penduduk telah menyebabkan perubahan lahan pertanian menjadi lahan non-pertanian. Solusi inovatif untuk mengatasi keterbatasan lahan yaitu urban agriculture, khususnya hidroponik. Namun, kondisi nutrisi pada air hidroponik sering kali dalam kondisi buruk sehingga perlu dimonitoring dan dideteksi tingkat kualitasnya untuk menjaga kondisi air nutrisi dalam bak hidroponik dalam keadaan baik. Kondisi air nutrisi yang baik akan mengoptimalkan proses penyerapan akar dan pertumbuhan tanaman. Parameter kualitas air nutrisi dapat dideteksi melalui suhu air nutrisi, kadar TDS (Total Dissolved Solids) di dalam nutrisi, dan tingkat keasamaan atau pH dari air nutrisi di dalam bak hidroponik. Metode fuzzy logic classification memungkinkan dalam mengolah kondisi aktual nutrisi dari ketiga parameter tersebut menjadi sebuah keputusan level kualitas air nutrisi tanaman dalam kondisi baik, sedang, buruk, ataupun sangat buruk. Penelitian ini menggunakan sensor suhu air, TDS, dan pH dalam pengukuran masing-masing parameter yang kemudian ditampilkan pada website. Hasil pengukuran parameter nutrisi mencapai error rendah yaitu ±5%. Hasil klasifikasi kualitas dari kondisi air nutrisi tanaman yang diputuskan dengan fuzzy logic sudah sesuai dengan yang diinginkan oleh petani dan berhasil 100% ditampilkan pada website pengguna. Sistem ini memudahkan pengguna dalam memantau, mengevaluasi, dan meningkatkan kondisi dan kualitas nutrisi tanaman dari jarak jauh.

Abstract The hemibiotrophic Basidiomycete pathogen Ganoderma boninense (Gb) is the dominant causal agent of oil palm basal stem rot disease. Here, we report a complete chromosomal genome map of Gb using a combination of short-read Illumina and long-read Pacific Biosciences (PacBio) sequencing platforms combined with chromatin conformation capture data from the Chicago and Hi-C platforms. The genome was 55.87 Mb in length and assembled to a high contiguity (N50: 304.34 kb) of 12 chromosomes built from 112 scaffolds, with a total of only 4.34 Mb (~ 7.77%) remaining unplaced. The final assemblies were evaluated for completeness of the genome by using Benchmarking Universal Single Copy Orthologs (BUSCO) v4.1.4, and based on 4464 total BUSCO polyporales group searches, the assemblies yielded 4264 (95.52%) of the conserved orthologs as complete and only a few fragmented BUSCO of 42 (0.94%) as well as a missing BUSCO of 158 (3.53%). Genome annotation predicted a total of 21,074 coding genes, with a GC content ratio of 59.2%. The genome features were analyzed with different databases, which revealed 2471 Gene Ontology/GO (11.72%), 5418 KEGG (Kyoto Encyclopedia of Genes and Genomes) Orthologous/KO (25.71%), 13,913 Cluster of Orthologous Groups of proteins/COG (66.02%), 60 ABC transporter (0.28%), 1049 Carbohydrate-Active Enzymes/CAZy (4.98%), 4005 pathogen–host interactions/PHI (19%), and 515 fungal transcription factor/FTFD (2.44%) genes. The results obtained in this study provide deep insight for further studies in the future.

Character is the "soul" of education as a whole, encompassing all phases of planning, carrying out, supervising, and evaluating instruction. In order to raise the standard of instruction at SDN 2 Rimo, this study tries to explain how curriculum management based on strengthening character education (PPK) is implemented. This study combines a case study methodology with a qualitative approach. While documentation studies were used to gather secondary data, interviews and observation were used to collect primary research data. The study's findings indicate that SD Negeri 2 Rimo's curriculum management program has a significant positive impact on character education that is delivered in the classroom, in the school's culture, and in the community. This is evident from the classroom activities, which include the students' behavior in adhering to the rules and the teacher's increased attention to detail when presenting the lesson plan. Additionally, children have demonstrated excellent attitudes and character in extracurricular activities and are able to interact cordially with peers and parents. Therefore, enhancing character education has a significant impact on raising learning standards.

Abstract Phosphorus plays a crucial role in controlling biological productivity, but geological estimates of phosphate concentrations in the Precambrian ocean, during life’s origin and early evolution, vary over several orders of magnitude. While reduced phosphorus species may have served as alternative substrates to phosphate, their bioavailability on the early Earth remains unknown. Here, we reconstruct the phylogenomic record of life on Earth and find that phosphate transporting genes (pnas) evolved in the Paleoarchean (ca. 3.6-3.2 Ga) and are consistent with phosphate concentrations above modern levels ( > 3 µM). The first gene optimized for low phosphate levels (pstS;

High-reliability diagnostic equipment efficiently supported by a computer-based diagnostics system. For instance, a computational approach establishes a model that can diagnose diseases. Artificial intelligence has been applied to aid in the field of medical imaging. Classification, prediction, and localisation of lesions or dental caries greatly minimise the load and difficulties for clinical practitioners. In this study, U-Net architectures are simplified to propose the feature reduction of the decoder layers. This simplification of U-Net architectures is utilised for segmented dental caries images. This paper simplified the U-Net decoder layers into the level of blocks Half-UNet () and Half-UNet (). The Half-UNet structural model surpasses the U-shaped structural model in terms of efficiency and segmentation capabilities. The simplification of the UNet architecture outperformed using Half-UNet 0.83% of the dice coefficient. The Half-UNet design is able to preserve model performance in segmenting actual images and ground truth against expected ground truth.

HIGHLIGHTS • This study unveils a dose-dependent relationship between Moringa leaf extract and increased Graafian follicle size in female mice. • The significant positive effect of Moringa leaf extract on Graafian follicles suggests promising implications for fertility interventions, offering hope for individuals seeking natural treatment to address infertility challenges. ABSTRACT Objective: This study aimed to determine the effect of Moringa leaf extract (Moringa oleifera Lam.) on the diameter of Graafian follicles in female mice (Mus musculus). Materials and Methods: This study used experimental design, employing a cohort of 24 female mice of 20-25 grams in weight, aged between 2-3 months, and in good health. These subjects were divided into three treatment groups and subjected to oral doses of Moringa leaf extract at 300 mg/kg BW, 400 mg/kg BW, and 500 mg/kg BW over a 14-day period. The study procedures involved the preparation of the experimental animals, preparation of Moringa leaf extract, treatments administration, and the preparation of histological specimens. Subsequently, the diameters of Graafian follicles within each treatment group were measured. Data analysis were performed using the ANOVA test (p

Purpose This article aimed to explore the Muslim mothers' understanding of breastfeeding verses, the factors of the role of ulama, community organizations, and the impact of understanding verses on breastfeeding practices. Method The study was qualitative research employing a descriptive case study design. It involved Muslim preachers and mothers as the key informants in Yogyakarta. Intensive observation and interview were done to get the intended data. The collected data and information were qualitatively analyzed to unveil Muslim mothers’ understanding of breastfeeding in Islam. Results/findings The study' showed those who believed that the Quran obligated breastfeeding did it as an attempt to fulfill the obligations without understanding the benefits that come with it. This was a consequence of the absence of socialization of the breastfeeding-related Quranic verses' content. Conclusion The study concluded that Muslim preachers had not reached Muslim mothers in Yogyakarta with breastfeeding verses.

Penelitian ini dilatarbelakangi oleh adanya anak yang masih sulit melafalkan, membedakan dan mengetahui huruf hijaiyah dengan baik. Pentingnya pemahaman orang tua dalam memberikan stimulasi di rumah menjadi faktor mempengaruhi ketercapaian anak dalam pengenalan huruf hijaiyah. Pengenalan ini bertujuan mengatasi permasalahan huruf hijaiyah anak dengan memilih metode pembelajaran Al-Qur’an. Metode tilawati dapat dipilih karena menggabungkan lagu rost yang unik dengan pendekatan pembelajaran yang berbeda, sesuai untuk anak. Penelitian ini menggunakan metode deskriptif kualitatif melalui teknik pengumpulan data observasi, wawancara dan dokumentasi. Guru kelas sekaligus pengajar metode tilawati kelas b menjadi informan dalam penelitian ini. Teknik analisis dengan mereduksi data, penyajian data, verifikasi data. Hasil penelitian menunjukkan anak mampu mengetahui dan menyebutkan dengan urut huruf hijaiyah, namun anak belum mampu melafalkan, membedakan huruf karena banyak kesamaan dan dianggap sama bentuknya oleh anak. Orang tua perlu memberikan dukungan dengan melakukan pengulangan huruf hijaiyah dirumah untuk mengatasi kesulitan anak dalam pelafalan, sebagai pelengkap dari pembelajaran di sekolah.

The major royal jelly protein 2 (mrjp2) gene is one of the molecular markers that can discriminate between Apis cerana Fabricius and A. mellifera Linnaeus. Due to the lack of mrjp2 gene sequences registered in GenBank for Indonesian A. cerana and A. mellifera, DNA characterization and bioinformatics analysis were needed. This research aimed to characterize the exon-intron organization of mrjp2 genes for both Indonesian bee species and analyze the phylogenetic relationship with other mrjp family genes. DNA samples of Apis cerana and A. mellifera, collected from Bogor, were amplified using MF-MR primer at annealing temperatures of 47 oC and 50 oC, respectively. The length of A. cerana and A. mellifera DNA sequences were 579 and 597 bp, respectively. The DNA sequences of both species were comprised of partial exons 1, introns 1, exons 2, introns 2, and partial exon 3. The number of putative amino acids of A. cerana and A. mellifera mrjp2 genes were 111 and 123, respectively. We confirmed that the partial MRJP2 putative amino acids of both honey bees belong to the MRJP family and contained the peptide signal in the 14 first amino acid sites. Nucleotide variation of the mrjp2 gene in A. cerana was higher than A. mellifera. Phylogenetic tree construction showed that A. cerana and A. mellifera form a monophyletic clade with the A. mellifera mrjp7 gene and another mrjp family gene clustered as reported in a previous study.

Banana peel is one of the wastes that can be explored for various applications. Cavendish is among the most highly consumed bananas in the world, which implies a high amount of banana peel waste. Our study evaluated the potential of Cavendish banana peels as the source of antioxidant and anti-aging agents. Antioxidant was extracted using three different solvents, i.e., water, ethyl acetate, and methanol. Each extract was then assayed for antioxidant activity in vitro using a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The antioxidant and anti-aging activity of the extracts were further evaluated at the cellular level using the yeast Schizosaccharomyces pombe as a model. Our data indicated that the methanol extract of banana peel showed the highest antioxidant activity with an IC50 value of 253.8 µg mL-1 compared to ethyl acetate and water, yet it was considered weak. Interestingly, the methanol extract (600 ppm) showed antioxidant and anti-aging activities at cellular levels in yeast S. pombe. Therefore, this research reveals the potential for developing banana peel methanol extract as a component of pharmaceutical or cosmetic products with antioxidant and anti-aging properties.

Abstract The motor neuroscience literature suggests that the central nervous system may encode some motor commands in terms of velocity. In this work, we tackle the question: what consequences would velocity commands produce at the behavioral level? Considering the ubiquitous presence of noise in the neuromusculoskeletal system, we predict that velocity commands affected by stationary noise would produce “random walks”, also known as Brownian processes, in position. Brownian motions are distinctively characterized by a linearly growing variance and a power spectral density that declines in inverse proportion to frequency. This work first shows that these Brownian processes are indeed observed in unbounded motion tasks e.g., rotating a crank. We further predict that such growing variance would still be present, but bounded, in tasks requiring a constant posture e.g., maintaining a static hand position or quietly standing. This hypothesis was also confirmed by experimental observations. A series of descriptive models are investigated to justify the observed behavior. Interestingly, one of the models capable of accounting for all the experimental results must feature forward-path velocity commands corrupted by stationary noise. The results of this work provide behavioral support for the hypothesis that humans plan the motion components of their actions in terms of velocity.

Abstract Background The use of simulated patients (SPs) to assess medical students’ clinical performance is gaining prominence, underscored by patient safety perspective. However, few reports have investigated the validity of such assessment. Here, we examined the validity and reliability of an assessment tool that serves as a standardized tool for SPs to assess medical students’ medical interview. Methods This longitudinal survey was conducted at Keio University School of Medicine in Japan from 2014 to 2021. To establish content validity, the simulated patient assessment tool (SPAT) was developed by several medical education specialists from 2008 to 2013. A cohort of 36 SPs assessed the performance of 831 medical students in clinical practice medical interview sessions from April 2014 to December 2021. The assessment’s internal structure was analyzed using descriptive statistics (maximum, minimum, median, mean, and standard deviation) for the SPAT’s 13 item total scores. Structural validity was examined with exploratory factor analysis, and internal consistency with Cronbach’s alpha coefficients. The mean SPAT total scores across different SPs and scenarios were compared using one way analysis of variance (ANOVA). Convergent validity was determined by correlating SPAT with the post-clinical clerkship obstructive structured clinical examination (post-CC OSCE) total scores using Pearson’s correlation coefficient. Results Of the 831 assessment sheets, 36 with missing values were excluded, leaving 795 for analysis. Thirty-five SPs, excluding one SP who quit in 2014, completed 795 assessments, for a response rate of 95.6%. Exploratory factor analysis revealed two factors, communication and physician performance. The overall Cronbach’s alpha coefficient was 0.929. Significant differences in SPAT total scores were observed across SPs and scenarios via one-way ANOVA. A moderate correlation (r =.212, p

Abstract Background Malaria is known to be the main cause of death in malaria-endemic areas. The authors report a case of severe malaria in an adult with no history of travel from an endemic area with good outcomes after hospitalization. Case presentation A 46-year-old man was brought to the Emergency Room (ER) because of fever and chills for 6 days. Complaints were accompanied by nausea and vomiting three times a day. The patient also experienced headaches, weakness, coughing, and a runny nose after two days of admission. The patient had no history of traveling from a malaria-endemic area. The patient was transferred from the Emergency Department (ED) to the High Care Unit (HCU), and during 1 day of intensive care at the HCU, there was a clinical deterioration characterized by dyspnea, icteric sclerae, acral edema, tenderness in both calves, and rash in the abdominal area. Due to worsening respiratory function, the patient was placed on a ventilator. During intensive treatment, the patient continued to show deterioration. The clinical findings suggested a possible feature of Weil’s disease or fulminant hepatitis, and although the patient was in intensive care, there was no clinically significant improvement. Furthermore, microscopic blood smear examination and rapid diagnostic tests (RDTs) for malaria were carried out on the 4th day of treatment with negative results. As there was no clinically significant improvement, it was decided to take a blood smear and repeat RDT on the twelfth day, which showed a positive result for falciparum malaria. Subsequently, artesunate was administered intravenously, and the patient’s condition began to improve with a negative parasite count the following day. The patient was discharged in good clinical condition on day 25 of treatment. Conclusion Good quality malaria diagnostic techniques are essential to diagnose malaria. A timely diagnosis of malaria has the potential to save the patient. Because Jakarta is not a malaria endemic area, it was concluded that this case was an introduced malaria case.

Magnetite, a widely synthesized compound utilized as an adsorbent in various processes, exhibits reduced adsorption efficiency due to aggregation in aqueous solutions. Addressing this limitation, modification of magnetite is necessary to mitigate agglomeration and enhance adsorption capacity. Herein, we propose the utilization of gaharu leaf extract for magnetite modification, leveraging its abundance as a byproduct of essential oil production and rich secondary metabolite content, which serves as a stabilizing agent in synthesis processes. Magnetite (M) and gaharu leaf extract-modified magnetite (MEDG) were synthesized and evaluated as adsorbents for methyl orange (MO) textile dyes. Characterization via FTIR, PSA, SEM-EDX, XRD, and VSM revealed distinctive features of MEDG, including vibrational peaks corresponding to organic functional groups derived from the secondary metabolites present in the gaharu leaf extract. These functional groups actively participate in the adsorption process and prevent magnetite aggregation. MEDG exhibited a particle size of 4408.7 nm, compared to 4625 nm for M, with both exhibiting face-centered cubic (fcc) crystal structures. Additionally, MEDG demonstrated a crystallinity percentage of 92.49 % and saturation magnetization of 34.43 emu/g, attributed to the incorporation of gaharu leaf extract. Adsorption studies demonstrated that MEDG and gaharu leaf simplicia (SDG) achieved maximal adsorption of MO at pH 3 for 60 min and pH 4 for 70 min, respectively, with an adsorption efficiency of 95–99 % for a 5 ppm MO solution. The adsorption kinetics followed Ho’s pseudo-second-order model, and the isotherm conformed to Freundlich’s model. Furthermore, M and MEDG exhibited high reusability, with up to 5 cycles of reuse, while SDG demonstrated 3 cycles. However, the adsorption efficiency decreased to 87 % for MEDG and 85.19 % for SDG upon the fifth repetition. In conclusion, modification of magnetite with gaharu leaf extract enhances its adsorption capacity, offering economic advantages over pure magnetite due to increased surface area and active sites.

A 43-year-old woman, with a history of uterine fibroids and multiple myomectomy, presented with acute lower abdominal pain. Computed tomography revealed multiple tumors, including a high-density mass in the left lower abdomen indicative of a parasitic leiomyoma undergoing red degeneration. This uncommon condition is due to acute occlusion, often caused by peripheral venous thrombosis at the fibroid edge. The diagnosis was corroborated by distinctive findings on magnetic resonance imaging and computed tomography. Notably, high signal intensity on T1-weighted images (T1WI) suggested methemoglobin presence due to hemorrhagic infarction, whereas low signal intensity on T2-weighted images (T2WI) indicated deoxyhemoglobin. Symptom improvement followed treatment with analgesics. This case underscores the significance of considering parasitic myomas in the differential diagnosis of intraperitoneal tumors after myomectomy and proposes that vascular torsion from mechanical stress on the mobile mesentery may contribute to red degeneration in such tumors. In this report, we detail the imaging characteristics and clinical progression of red degeneration in a parasitic leiomyoma, emphasizing the importance of this diagnosis in patients with a history of uterine surgery.

The global production of commercial aquatic plants, which includes macroalgae, has reached 31.2 million. To unlock the vast potential of brown algae as abundant sources of diverse bioactive compounds, efficient extraction methods aligned with sustainability goals are crucial. This comprehensive review delves into the paradigm shift towards green extraction techniques tailored for brown algae. The bioactive compounds present in brown algae hold substantial industrial value, extending across pharmaceuticals, cosmetics, food, and agriculture. However, conventional methods like solvent extraction and hydro distillation face challenges related to environmental impact and efficiency. The review emphasizes the principles of green extraction and thoroughly examines advanced methods such as supercritical fluid extraction (SFE), microwave-assisted extraction (MAE), and subcritical water extraction (SWE), providing insights into their mechanisms, advantages, and applications. This review gathers information from articles published in English between 2004 and 2023. While recognizing the obstacles in implementing green methods, the review also outlines future directions for sustainable extraction of bioactive compounds from brown algae. By embracing eco-friendly techniques, both researchers and industries can effectively harness bioactive compounds while contributing to environmental well-being.

Hydroponics is a method of cultivation that does not use soil as a medium, allowing it to be applied in limited spaces such as urban households. One of the vegetable plants that can be grown using hydroponics is pak choy (Brassica rapa subsp. chinensis). To produce healthy pak choy plants that can efficiently absorb nutrients in a hydroponic system, several factors need to be considered, such as the level of Total Dissolved Solids (TDS) in the nutrient solution, nutrient solution temperature, and air humidity in the hydroponic environment. The ideal nutrient solution temperature for hydroponic plants falls within the range of 25-27°C. In this system, a monitoring and control system will be designed to optimize the growth of pak choy plants in a Deep Flow Technique (DFT) hydroponic system. In this system, the nutrient solution temperature will be controlled with a set point of 25°C using an on/off control for a peltier device. To maintain the TDS level at a set point of 1200 ppm in the nutrient solution, fuzzy logic control will be employed, generating timer-based control signals for the nutrient pump A, nutrient pump B, and water pump. The monitoring system will be displayed on an Internet of Things (IoT) dashboard platform, such as ThingSpeak.

Kejujuran merupakan salah satu nilai moral yang penting untuk ditanamkan sejak dini. Salah satu pendekatan yang dapat digunakan untuk mengajarkan nilai atau karakter kejujuran adalah melalui media permainan edukatif. Artikel ini menguraikan kegiatan Pengabdian Masyarakat dengan tema “Jujur itu Asyik Jujur itu Keren yang dilakukan di Taman Baca Inklusi Sentra Terpadu Pangudi Luhur yang ada di wilayah Bekasi Timur Jawa Barat, dengan menggunakan game “Semai” sebagai alat untuk menanamkan kejujuran pada anak-anak. Game ini dirancang untuk mengedukasi tentang kejujuran dalam interaksi sosial di antara para pemain. Kegiatan ini melibatkan metode partisipatif dengan melibatkan anak-anak dalam permainan serta refleksi setelah bermain untuk menanamkan nilai-nilai kejujuran. Hasil kegiatan menunjukkan adanya peningkatan pemahaman anak-anak tentang pentingnya bersikap jujur dalam kehidupan sehari-hari.

Dalam dunia bisnis yang semakin kompetitif, Madu Silvia menghadapi tantangan untuk terus berkembang dan mempertahankan posisinya di pasar. Untuk mencapai pertumbuhan yang berkelanjutan, optimalisasi dalam manajemen usaha menjadi kunci yang sangat penting. Madu Silvia merupakan Unit usaha perorangan dibidang peternakan lebah madu hingga produk siap untuk dipasarkan. Permasalahan yang dihadapi yaitu kurangnya manajemen usaha lebah madu pasca panen. Oleh karena itu, dilakukan pelatihan pembukuan dan manajemen yang tepat guna meningkatkan efisiensi operasional Madu Silvia, serta peran strategis branding dalam memperkuat identitas produk di mata konsumen. Dengan penerapan pembukuan yang akurat, Madu Silvia dapat memonitor keuangan secara lebih baik, membuat keputusan bisnis yang tepat, dan mengurangi risiko kesalahan. Di sisi lain, pendampingan branding memberikan panduan untuk menciptakan citra yang kuat dan autentik, yang akan membantu produk Madu Silvia lebih dikenal, dipercaya, dan diminati di pasar. Hasil dari kegiatan pengabdian ini menunjukkan adanya peningkatan pemahaman pemilik usaha Madu Silvia terhadap pentingnya pembukuan dan manajemen yang baik serta strategi branding yang efektif. Pemilik kini lebih mampu mengelola keuangan usaha secara mandiri, dan mengimplementasikan strategi branding yang sesuai dengan karakteristik produk mereka. Dengan kombinasi yang tepat antara pembukuan, manajemen, dan branding, Madu Silvia diharapkan dapat mencapai pertumbuhan yang lebih cepat dan berkelanjutan.

This study examines the influence of the marketing mix and brand image on consumer satisfaction and repurchase intention in Kampung Pempek 26 Ilir, a designated center for purchasing pempek and souvenirs in Palembang. The research aims to identify key factors that drive repeat visits and improve sales for this tourism and culinary destination. A quantitative approach with descriptive analysis was utilized, targeting residents of Palembang who have visited Kampung Pempek 26 Ilir. A total of 210 respondents were selected using accidental sampling. Data analysis measured the direct and mediated effects of the marketing mix and brand image on consumer satisfaction and repurchase intention. The marketing mix showed a positive and significant influence on repurchase intentions and consumer satisfaction. When mediated by consumer satisfaction, the marketing mix had an additional positive effect on repurchase intention. Brand image also significantly influenced repurchase intention and consumer satisfaction. Findings suggest that both the marketing mix and brand image are crucial in enhancing consumer satisfaction and encouraging repeat visits to Kampung Pempek 26 Ilir. The positive mediation effects of consumer satisfaction indicate its role as an essential bridge between marketing strategies and consumer loyalty. The study concludes that improving both the marketing mix and brand image can substantially enhance consumer satisfaction and repurchase intention. Specifically, consumer satisfaction is a pivotal factor in increasing consumer loyalty and the likelihood of repeat purchases. The recommendation for Kampung Pempek 26 Ilir is to invest in optimizing its marketing strategies and brand image to enhance consumer satisfaction. Further studies could explore additional factors that influence consumer loyalty in similar cultural and culinary tourism centers.

Mauritius raspberry (Rubus rosifolius) is an exotic plant cultivated in Indonesia. Studies showed that the productivity of exotic plants is reducing due to a lack of pollination agent for their origin region. Several methods could be applied to overcome this problem. The study aimed to find the most effective method for pollinating this plant among four pollination regimes: Self-pollination, wild insects, stingless bees (Tetragonula laeviceps), and hand-pollination. The observation was conducted on the insect pollinators' activities (visitation rate, flower constancy, and flower handling time), pollination efficiency, and quality of the fruits produced (fruit volume). The results showed a higher visitation rate (10 to 70 per hour), higher flower constancy (visited from 07.00 to 16.00), and longer flower handling time (13.6 s) of T. laeviceps on raspberry flowers than other insects. High activities related to better raspberry pollination success (96%) and bigger fruits produced. Based on this study, applying stingless bees as pollination agents for exotic plants was the best and potentially applicable to other exotic crops.

Pembelajaran biologi yang mempelajari tentang makhluk hidup mempunyai daya tarik tersendiri yang menarik minat dan perhatian peserta didik saat belajar. Namun banyak siswa yang menganggap biologi adalah mata pelajaran yang sulit dan membosankan. Oleh karena itu, sangat penting bagi guru untuk berperan aktif dalam mengelola pembelajaran di kelas, mengubah persepsi siswa dan meningkatkan hasil belajar siswa. Tujuan penelitian ini adalah untuk mengetahui peningkatan hasil belajar siswa dengan menerapkan model learning cycle dalam pembelajaran IPA. Penelitian ini merupakan penelitian Tindakan kelas (PTK) atau Classroom Action Research. Penelitian dengan menggunakan model Learning cycle ini dilakukan sebanyak 2 Siklus yaitu Siklus I dan Siklus II dimana setip siklusnya terdiri dari 3 kali pertemuan. Penelitian ini telah dilaksanakan pada bulan Mei di MTsS Darul Istiqamah Tahun Ajaran 2023/2024. Sample dalam penelitian ini adalah Siswa Kelas VIII yang terdiri dari 19 Siswa. Dalam penelitian PTK dengan menggunakan model Learning Cycle ini dilakukan beberapa Tahapan yakni Perencanaan, pelaksanaan tindakan, observasi atau pengamatan, evaluasi dan refleksi. Hasil penelitian yang telah dilakukan dengan menerapkan Model Learning Cycle terjadi peningkatan ketuntasan belajar pada siklus I sebanyak 47,37% ke siklus II sebanyak 100%. Pada siklus I dalam implementasi model Learning Cycle dimana siswa belum mampu menerapkan konsep yang akan dipelajari dan masih kurang peduli dengan materi yang diberikan oleh Guru yang menyebabkan siswa kurang memperhatikan penjelasan dari Guru. Pada Siklus II Guru juga sudah menguasai kelas dan menyampaikan materi dengan baik sehingga hasil belajar siswa pada siklus II semuanya Tuntas.

Dog owners are greatly concerned about tick infestations in their pets. The prevalence and dispersion of ticks and their disease-causing microorganisms have been limited from the viewpoint of dog owners in Vietnam. This study investigated the presence of tick infestation and the pathogens associated with it in canines that were brought to veterinary hospitals in Vietnam. In the survey, 1,423 dogs participated from February to October 2022. Molecular and morphological methods were utilized to identify ticks and the associated pathogens. In addition,risk variables linked to tick infestation were documented and analyzed using statistical methods. The total exposure to the brown dog tick (Rhipicephalus sanguineus sensu lato) was 29.01%. Nam Dinh has the highest tick prevalence among the research areas. Tick infestation reached its highest point between June and September in the northern region of the country, with distinct seasons showing a strong correlation with tick infestation in dogs. Out of 177 tick pools examined, 146(82.49%) tested positive for at least one infection. Mycoplasma spp. (78.53%) was the most common, followed by Anaplasma spp. (37.29%), Rickettsia felis (5.08%), Babesia vogeli, and Hepatozoon canis (2.82%). In the current study, there was a statistically significant link between tick infestation and characteristics such as age, breed, body size, lifestyle, and bathing frequency. Understanding the seasonal behavior of vector ticks is crucial for identifying individuals or animals susceptible to tick-borne diseases. Studying the distribution of ticks and their ability to carry and disseminate zoonotic germs in specific places could assist veterinarians and policymakers in implementing effective strategies to manage zoonotic infections.

Okra (Abelmochus esculentus L. Moench) has a fairly high nutritional content; every 10 gr of young okra fruit contains 33 calories, 7 gs of carbohydrates, 3.2 gs of fiber, and 81 mg calcium. Okra fruit contains a lot of mucilage due to its high fiber content. This study aimed to determine the effect of rock phosphate doses and types of mycorrhizae and the interaction between these two factors on the growth and yield of okra in saline soil. The research results showed that the dose of mycorrhiza had a very significant effect on the growth and yield of okra plants. The best dose of mycorrhiza was 10 g/plant, and the best type was Acauluspora. It showed that a dose of 10 g/plant with the Acauluspora type on okra yields on Ultiisol soil had given the best results in the vegetative phase, which could be seen in plant height parameters 15 and 30 ADP. The dose of rock phosphate is 150 g, which can be seen in the 300 g planting parameter and in almost all the observed variables. Hyphae in the soil can spread widely, which helps absorb more water. The best yields of okra plants were found by applying a mycorrhizal dose of 10 g on fruit weight variables of plants' mycorrhizal colonization on vase vegetative roots and mycorrhizal colonization on plant roots in the generative phase. Keywords: biological agents, fertilizer, mycorrhiza, rock phosphate

In the child and youth care sector, protecting vulnerable children is a key priority, one that requires a skilled workforce capable of meeting diverse and complex needs. Starting with an acknowledgement of the field’s struggle for identity, this article briefly recounts highlights of our journey to achieving recognition as a profession, with an emphasis on the South African context. The profession’s early phase is described along with the key developments that have shaped the scope of practice, leading to a discussion of current matters that have the potential to transform the field, and ideas regarding priorities that may need to be considered for a longer-term agenda. Reflections on a journey that builds on lessons from South Africa as they connect to a wider global context are shared. The initiatives shared within this journey reflect a resilient sector that has contributed to the creation of employment opportunities for child carers. They also provide some milestones for the formalising of a sector that requires regulation because of the vulnerable population it serves. From the emerging priorities, pointers for the next steps in the profession’s journey are offered.

Callosobruchus maculatus merupakan salah satu hama pascapenan pada biji kacang hijau. Aktivitas makan dari hama ini menyebabkan menurunnya kualitas dan kuantitas biji kacang hijau. Pengendalian dengan fumigant insektisida nabati dapat menyebabkan residu pada biji kacang hijau dan menghambat perkecambahan biji kacang hijau pada saat tanam. Oleh karena diperlukan teknologi pengendalian yang ramah lingkungan, salah satunya adalah menggunakan insektisida nabati dari biji Annona muricata dan Schleicera oleosa. Kandidat insektisida nabati dari dua tumbuhan asal Pulau Timor belum pernah diuji. Oleh karena itu perlu dilakukan penelitian dengan tujuan untuk mengetahui pengaruh ektrak biji A. muricata dan S. oleosa terhadap mortalitas imago C. maculatus. Penelitian ini dilaksanakan di Laboratorium Hama Tumbuhan. Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL). Perlakuan menggunakan metode kontak yaitu residu pada permukaan cawan. Setiap perlakuan terdiri dari lima konsentrasi yaitu 0,06%; 0,125%, 0,25%; 0,5%; 1 %; dan kontrol. Setiap perlakuan diulang tiga kali. Pada setiap ulangan diinfestasi dengan 10 pasang imago C. maculatus. Varieable pengamatan adalah mortalitas dan gejala kematian. Data mortalitas dihitung 24 Jam Setelah Perlakuan (JPS) sampai dengan 72 JPS. Data mortalitas dianalisis menggunakan program POLO PC. Ekstrak biji A. muricata dan S. oleosa menyebabkan kematian imago C. maculatus. Kematian imago C. maculatus yang diberi dengan ekstrak biji sirsak sebesar 96,66% pada konsentrasi tertinggi (1%). Sedangkan pada ekstrak biji kusambi pada konsentrasi yang sama mortalitas sebesar 88,33%. Hasil analisis probit menunjukan bahwa nilai LC50 dan LC95 ekstrak biji sirsak terhadap imago C. maculatus sebesar 0,10% dan 0,81%,sedangkan untuk esktrak biji kusambi LC50 dan LC95 sebesar 0,12% dan 1,50%. Dengan demikian ekstrak biji A. muricata dan S. oleosa asal daerah lahan kering di Pulau Timor memiliki potensi untuk dikembangakan sebagai insektisida nabati

A validated instrument is crucial for assessing oncology nursing care in Indonesia. This study focused on translating, adapting, and validating the QONCS among Indonesian cancer patients and families. Initial feedback from nursing academicians and pilot participants guided the adaptation process. Validation involved distributing the instrument via Google Forms to 8 cancer referral hospitals, gathering responses from 148 individuals. Confirmatory factor analysis (CFA) assessed validity, while Cronbach's alpha measured internal consistency. Synonyms and examples were added to enhance item clarity. Eight items were removed due to poor construct validity, resulting in improved statistics (r statistic: 0.653-0.818; average variance extracted: 0.742). The revised instrument demonstrated high reliability (Cronbach's alpha: 0.967). This study confirms the Indonesian QONCS version as a valid and reliable tool for evaluating oncology nursing care. It is recommended for oncology nurses to utilize the QONCS to enhance the quality of care provided.

The purpose of this research is to improve clothing marketing at Irma Collection with Bootstrap 3 because Irma Collection does not have a means or system to spread its products. Customers must come directly to the store, this causes customers to ask first about detailed information about the product so that it is less effective because there is no facility that helps customers to find out information about the product. Irma Collection really needs improvement, namely the construction of a system in order to provide good service and satisfy customer interest and make it easier for owners to recap reports on goods sold. With the Customer Relationship Management (CRM) system, it is expected that Irma Collection will be easier to attract many customers and maintain customer interest to become regular customers at Irma Collection.

Broccoli is abundant in fiber, vitamins, and minerals and is useful as a complement to main dishes. However, the use of broccoli during baking is still limited. Therefore, an experiment was conducted to explore the use of broccoli as a substitute in the recipe of a traditional cake, Kue Lumpur, as a traditional Indonesian snack for various events. This study aimed to determine how to make green broccoli puree, the process of making Kue Lumpur with green broccoli puree substitution, the response of panelists, and the nutritional content of Kue Lumpur from green broccoli puree substitution. The experimental design research was conducted at Makassar State University from December 2021 to February 2022. The participants were 16 trained panelists. Data collection was carried out using documentation and questionnaires (Scoresheet). The process of making broccoli puree involves separation, blanching, steaming, and mashing in four formulations: F1 (10%), F2 (20%), F3 (30%), and F4 (40%). Data were analyzed using ANOVA and Duncan's t-test. The organoleptic Kue Lumpur with green broccoli puree substitution had significant acceptability (p

Latar Belakang: Luka bakar merupakan trauma yang sering terjadi dalam kehidupan sehari - hari, dengan angka morbiditas dan mortalitas yang cukup tinggi. Kasus luka bakar pada korban hidup maupun meninggal memiliki arti penting dalam investigasi forensik. Objektif: Untuk mengetahui gambaran kasus luka bakar di Departemen Forensik RSUP Dr. M. Djamil Padang pada tahun 2010 - 2020. Metode: Penelitian deskriptif dengan desain cross-sectional, menggunakan data Rekam Medis Forensik terhadap 131 kasus luka bakar dengan teknik total sampling. Hasil: Ditemukan 131 kasus luka bakar yang memenuhi kriteria inklusi dan eksklusi. Karakteristik korban luka bakar meliputi; terbanyak pada laki - laki (76,3%), rentang usia 18 - 39 tahun (51,1%), penyebab karena api (57,3%), derajat II (58,9%), rentang luas luka 0 - 20% (45,8%), lokasi di ekstremitas atas (19,7%), dan tempat kejadian di rumah korban (40,5%). Mayoritas kasus luka bakar diakibatkan kecelakaan (96,2%), dengan kelompok terbanyak ditemukan pada korban hidup (91,6%). Mayoritas kasus luka bakar termasuk derajat luka sedang (74,2%). Kesimpulan: Kasus luka bakar ditemukan terbanyak pada laki -laki, pada kelompok usia 18 - 39 tahun, penyebab karena api, derajat II, dengan rentang luas luka 0 - 20%, lokasi di ekstremitas atas, dan tempat kejadian di rumah korban. Mayoritas kasus luka bakar diakibatkan kecelakaan, dengan kelompok terbanyak ditemukan pada korban hidup, dan termasuk derajat luka sedang. Kata Kunci: luka bakar, forensik

Peripheral Arterial Disease (PAD) is the third leading cause of atheroskeric vascular morbidity in coronary heart disease. The ankle-brachial index (ABI) is one way to assess peripheral arteries. This activity aims to identify people who are at risk or suffer from PAD. The method used is a medical examination, which includes ABI values, blood pressure, cholesterol levels, blood sugar, and uric acid. This medical examination was conducted on 41 people in RT 02 RW 06 Pasar Ambacang, Padang City. The screening results found that 17.07% of respondents had ABI values higher than 1.3 (severely calcified vessel), and 14.62% had ABI values in the range of 0.71-0.9 (mild obstruction). This activity also found respondents with first-stage hypertension (29.26%), second-stage hypertension (2.44%), high cholesterol levels (56.09%), high blood sugar levels (7.31%), and uric acid levels exceeding normal limits (7.31%). Screening efforts can be a preventive measure.

Long non-coding RNA (lncRNA) plays an important role in the regulation of gene expression in normal and cancer cells. We previously discovered a novel tumor-suppressive lncRNA, DRAIC, in prostate cancer cells. Subsequent studies have demonstrated that DRAIC is dysregulated in various malignancies and exhibits a tumor-suppressive or pro-oncogenic function. However, details regarding its expression pattern in normal and cancerous tissues remain largely unknown. In this study, we performed chromogenic in situ hybridization (CISH) using RNAscope technology to assess DRAIC expression in formalin-fixed paraffin-embedded (FFPE) specimens. In the neuroendocrine-differentiated cancer cell line VMRC-LCD, CISH revealed a diffuse localization of DRAIC in the cytoplasm as well as specific accumulation in the nuclear compartment. DRAIC expression was comprehensively analyzed using tissue microarrays containing 89 normal and 155 tumor tissue samples. DRAIC was weakly expressed in normal epithelial cells of the colon, bronchiole, kidney, prostate, and testis. Conversely, DRAIC was moderately to highly expressed in some cancer tissues, including prostate adenocarcinoma, invasive ductal carcinoma of the breast, neuroendocrine carcinoma of the esophagus, lung adenocarcinoma, and small cell lung carcinoma. While DRAIC knockdown did not affect VMRC-LCD cellular viability and invasive ability, gene expression related to the neuroendocrine and cancer-related pathways was altered. Our expression analysis revealed the specific expression pattern of DRAIC in normal and cancerous FFPE tissues. The results presented here may lead to the elucidation of additional novel functions of DRAIC.

Ownership structure and interest rates are important factors affecting a bank's performance. Previous studies have found the effect of ownership structure and interest rates on company performance, but no one has specifically examined differences in Banking performance in ownership structure and interest rates. This study aims to compare the performance of Islamic and conventional banking in ownership structure and interest rates. In study, the author used quantitative methods that emphasize the analysis of numerical data processed using Stata 16. Based on the unstructured data panel, there are 13 Islamic banking and 107 conventional banking, the total banks used as objects are 120 banks with 1110 observations. The results are local ownership did not affect the performance of Islamic banks, compared to conventional banking on the contrary. Foreign ownership in Islamic banking affects Banking performance, while conventional banking has no effect. Furthermore, government ownership affects the performance of Islamic banks, but does not affect the performance of conventional banking. Based on the results of the study, it can be proven that government and foreign interference in the ownership of Islamic banking plays a role in improving the bank's performance. Whereas conventional banking has performed well under local ownership.

The art of Islamic calligraphy developed along with the development of Islam brought by the Prophet Muhammad SAW. Until now, calligraphy has grown rapidly and become a popular work of art among the general public to various Islamic institutions. Especially in Islamic boarding schools in various regions, both traditional and modern. Researchers made the Wali Songo modern boarding school as an object of research. The purpose of conducting this research is so that researchers can find out the concept of calligraphy learning at the Wali Songo modern boarding school. Researchers used descriptive qualitative methods in conducting research, using a literature review approach to collect similar data, and conducting interviews with respondents who had a relationship with the Wali Songo modern boarding school. The results obtained from this research are that the Wali Songo modern boarding school uses modern media in the learning process such as blackboards, markers, blackboard rulers, notebooks, reference books, calligraphy special pens, and liquid ink. The students get special guidance from teachers who are competent in the field of calligraphy.

Strawberry generation, internet addiction disorder, consumerism, identity diffusion, and promiscuity are phenomena that affect adolescents today. One of the triggers of these things is the maturity of the amygdala first as the center of emotion control compared to the prefrontal cortex as the logical mind controller. Efforts are needed so that adolescents are not trapped in acts of delinquency or juvenile crime. Adult guidance in training social-emotional skills can be one of the efforts. Social-emotional skills are a process to hone the competence to recognize self-identity, recognize and manage emotions, be responsible in making decisions, be assertive, and apply effectively to various social demands. The curriculum design in this study was developed by adapting backward design with the stages of setting goals in the form of competencies expected to be attached to students, then determining activities or evidence to test the achievement of goals, and lastly, designing learning experiences. This research uses literature studies to find the theoretical basis of the phenomena that occur and design solutions to these phenomena. Social-emotional skills have a high level of urgency to be implemented because they can prevent delinquency and crime in adolescents and improve student academic achievement. Abstrak Generasi strawberry, gangguan kecanduan internet, konsumerisme, difusi identitas, dan pergaulan bebas adalah fenomena yang terjadi di remaja saat ini. Salah satu pemicu dari hal-hal tersebut adalah matangnya amigdala terlebih dahulu sebagai pusat pengendali emosi dibandingkan korteks prefrontal sebagai pengendali pikiran logis. Diperlukan upaya agar remaja tidak terjebak dalam tindakan kenakalan atau kejahatan remaja. Bimbingan orang dewasa dalam melatih keterampilan sosial-emosional dapat menjadi salah satu upaya. Keterampilan sosial-emosional merupakan suatu proses untuk mengasah kompetensi mengenali identitas diri, mengenali dan mengelola emosi, bertanggung jawab dalam mengambil keputusan, bersikap asertif, dan berlaku efektif terhadap berbagai tuntutan sosial. Desain kurikulum dalam penelitian ini dikembangkan dengan mengadaptasi backward design dengan tahapan menetapkan tujuan berupa kompetensi yang diharapkan melekat pada diri siswa, kemudian menentukan kegiatan atau bukti untuk menguji ketercapaian tujuan, dan yang terakhir adalah mendesain pengalaman belajar. Penelitian ini menggunakan studi literatur untuk mencari landasan teori dari fenomena yang terjadi dan merancang solusi untuk fenomena tersebut. Keterampilan sosial emosional memiliki tingkat urgensi yang tinggi untuk diimplementasikan karena tidak hanya dapat mencegah kenakalan dan kriminalitas pada remaja, tetapi juga dapat meningkatkan prestasi akademik siswa. Kata Kunci: Desain backward; desain kurikulum; keterampilan sosial emosional

Introduction: The research aimed to investigate the correlation between health literacy levels, medication adherence, and quality of life among hemodialysis patients with chronic kidney disease. Methods: The research employed a cross-sectional design. A random sample of 164 hemodialysis patients from two hemodialysis facilities in Padang, Indonesia, was collected between May and June 2023. Inclusion criteria were patients undergoing hemodialysis twice a week and aged over 18 years. Patients who experienced a decrease in consciousness and memory disorders such as dementia were excluded from this study. The questionnaires used to measure variables in this study were the demographic data questionnaire, the HLS-EU-Q16 health literacy questionnaire, the MMAS-8 medication adherence questionnaire, and the KDQOL-36 quality of life questionnaire for chronic kidney disease patients. Results: The high health literacy group (N = 73) exhibited a markedly superior quality of life compared to those in the mid-level (N = 48) and low-level (N = 43) health literacy groups. Multiple regression analysis revealed that, of the three components of health literacy, health promotion has the greatest influence on patients' quality of life, contributing 25.1%, while the aspect of healthcare has the greatest influence on medication adherence, contributing 43.3%. Conclusions: Health literacy is essential in improving medication adherence and the patient's quality of life in a more optimal direction. Healthcare professionals should create plans for tailored and customized health information with the goal of providing patients with the knowledge about critical components they need to manage chronic kidney disease.

Abstract Background This study reports the first cases of scleritis following intravitreal brolucizumab (IVBr) injection for nAMD, emphasizing the need to be aware of the possibility of scleritis following IVBr injections. Case presentation Case 1. A 74-year-old Japanese man with nAMD complained of conjunctivitis and decreased vision in the right eye 8 days after his eighth IVBr injection. Examination revealed scleritis without anterior inflammation. Topical 0.1% betamethasone and 0.3% gatifloxacin eye drops were started. The scleritis worsened in the following 2 weeks and became painful. He underwent sub-Tenon’s capsule triamcinolone acetonide (STTA) injection. Two days later, he returned with a complaint of severe vision loss. Fundus examination revealed retinal artery occlusion, vasculitis, and vitreous opacity in the right eye. Vitreous surgery was performed. Case 2. An 85-year-old Japanese woman with nAMD in the right eye complained of reddening of the eye 27 days after her fifth IVBr injection. Examination showed conjunctivitis and scleritis without anterior inflammation in the right eye. She was started on 0.1% fluorometholone and 0.5% levofloxacin hydrate eye drops. The scleritis worsened in the following 3 weeks. Her treatment was switched to 0.1% betamethasone eye drops. One month later, the scleritis had improved and a sixth IVBr injection was administered. There was no worsening of the scleritis at that time. However, 1 month after a seventh IVBr injection, she complained of severe hyperemia and decreased vision. Fundus examination revealed vitreous opacification. She underwent STTA, and the vitreous opacity improved in 24 days. Case 3. A 57-year-old Japanese man with nAMD complained of pain and decreased vision in the right eye 21 days after a fourth IVBr injection. Examination revealed scleritis with high intraocular pressure but no anterior chamber or fundus inflammation. STTA and topical eye drops were performed. One month later, scleritis improved but visual acuity didn’t due to progression of nAMD. Conclusions Intraocular inflammation following IVBr injection may progress to the posterior segment. Scleritis can occur after IVBr injection, and topical eye drops alone may not be sufficient for initial treatment. Clinicians should consider the possibility of scleritis in patients with worsening inflammation after IVBr injection.