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77 results on '"Richard S. Egan"'

51. ChemInform Abstract: THE DEOXYDATIVE SUBSTITUTION OF PYRIDINE N-OXIDES. PART XVI. CARBON-13 SPECTRA OF SOME TETRAHYDROPYRIDINES. THE STRUCTURE OF THE TETRAHYDROPYRIDINES FROM 3,5-LUTIDINE 1-OXIDE AND MERCAPTANS IN ACETIC ANHYDRIDE

Author

Richard S. Egan, J. M. Kokosa, I. Chu, and Ludwig Bauer

Subjects
Acetic anhydride, chemistry.chemical_compound, chemistry, Pyridine, Carbon-13, Substitution (logic), Polymer chemistry, Oxide, Organic chemistry, General Medicine, Spectral line
Published
1979
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52. Minor lankamycin-related antibiotics from Streptomyces violaceoniger

Author

Ruth S. Stanaszek, Jerry R. Martin, Walter Keller-Schierlein, Richard S. Egan, Jack Tadanier, and Alma W. Goldstein

Subjects
Jones oxidation, Magnetic Resonance Spectroscopy, Streptomyces violaceoniger, Chemistry, medicine.drug_class, Organic Chemistry, Antibiotics, Lankamycin, Biochemistry, Catalysis, Streptomyces, Anti-Bacterial Agents, Erythromycin, Inorganic Chemistry, Drug Discovery, medicine, Fermentation, Physical and Theoretical Chemistry
Abstract

Several previously undescribed metabolites related to lankamycin have been isolated from fermentation broths of the lankamycin-producing organism Streptomyces violaceoniger. Two of these metabolites, of weak antibacterical activity, have been characterized as 15-O-(α-L-4-O-acetyl-arcanosyl)-lankamycin and 15-deoxy-15-oxo-lankamycin. The latter antibiotic is prepared in high yield by Jones oxidation of lankamycin.

Published
1977

53. A new antibiotic XK-62-2. III The structure of XK-62-2, a new gentamicin C complex antibiotic

Author

Sandra L. Mueller, Richard S. Egan, Arthur C. Sinclair, Milton I. Levenberg, Ruth S. Stanaszek, and R. Larry Devault

Subjects
Pharmacology, Crystallography, Chemistry, Materials science, Chemical Phenomena, Computational chemistry, Drug Discovery, Chromatography, Thin Layer, Gentamicins, Methylation, Chemical decomposition, Mass Spectrometry
Abstract

The structure of XK-62-2 has been firmly established to be 6'-N-methylgentamicin C1a (3) by application of spectroscopic methods in conjunction with chemical degradation. The data obtained in every case are completely consistent with the proposed structure.

Published
1975

54. Spectinomycin modification. II. 7-EPI-sectinomycin

Author

Momir Cirovic, Toshinari Nishinaga, Richard S. Egan, Kenichi Mochida, William Rosenbrook, Yasuki Mori, Ruth S. Stanaszek, and Ronald E. Carney

Subjects
Pharmacology, Chemistry, Spectinomycin, Magnetic Resonance Spectroscopy, Chemical Phenomena, Stereochemistry, Drug Discovery, medicine, Proton magnetic resonance, medicine.drug
Abstract

7-Epi-spectinomycin (9) and 7-epi-4(R)-dihydrospectinomycin (10) have been prepared and their structures firmly established by proton magnetic resonance. Both of these spectinomycin analogs are devoid of antibiotic activity.

Published
1975

55. Letter: 8,8a-Deoxyoleandolide: elaborated by a blocked mutant of the erythromycin-producing organism Streptomyces erythreus

Author

Jerry R. Martin, Alma W. Goldstein, Esther. Hirner, Ruth S. Stanaszek, Sandra L. Mueller, and Richard S. Egan

Subjects
Pharmacology, Magnetic Resonance Spectroscopy, biology, Chemical Phenomena, Chemistry, Mutant, Erythromycin, biology.organism_classification, Streptomyces, Mass Spectrometry, Microbiology, Lactones, Drug Discovery, Mutation, medicine, Organism, medicine.drug, Oleandomycin
Published
1974

56. ChemInform Abstract: MINOR LANKAMYCIN-RELATED ANTIBIOTICS FROM STREPTOMYCES VIOLACEONIGER

Author

Jack Tadanier, Jerry R. Martin, Richard S. Egan, Ruth S. Stanaszek, Walter Keller-Schierlein, and Alma W. Goldstein

Subjects
Jones oxidation, Streptomyces violaceoniger, Biochemistry, Chemistry, medicine.drug_class, Yield (chemistry), Antibiotics, medicine, Lankamycin, Fermentation, General Medicine
Abstract

Several previously undescribed metabolites related to lankamycin have been isolated from fermentation broths of the lankamycin-producing organism Streptomyces violaceoniger. Two of these metabolites, of weak antibacterical activity, have been characterized as 15-O-(α-L-4-O-acetyl-arcanosyl)-lankamycin and 15-deoxy-15-oxo-lankamycin. The latter antibiotic is prepared in high yield by Jones oxidation of lankamycin.

Published
1978
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57. ChemInform Abstract: CHEMISTRY OF CHELOCARDIN. V. CONDENSATION WITH AMINO REAGENTS

Author

Ruth S. Stanaszek, David Lyon Garmaise, Stuart Nicholas Huckin, Daniel T. W. Chu, Edith Bernstein, and Richard S. Egan

Subjects
Chemistry, Reagent, Condensation, Organic chemistry, General Medicine, Chelocardin
Abstract

The nature of the products obtained from the reaction of chelocardin (1) and the model compound 2-acetyldimedone (5) with a variety of amines was investigated. It was observed that amines react wit...

Published
1981
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58. 4-N-Aminoacylfortimicins E

Author

Dave Grampovnik, Richard S. Egan, Daniel A. Dunnigan, Paulette Johnson, Paul Kurath, Preston Hill, Ruth S. Stanaszek, William H. Washburn, James E. Leonard, Momir Cirovic, Jerry R. Martin, Jack Tadanier, and Alma W. Goldstein

Subjects
Pharmacology, Magnetic Resonance Spectroscopy, biology, Bacteria, Chemical Phenomena, Metabolite, Microorganism, Antimicrobial, biology.organism_classification, Fortimicin B, Microbiology, Fortimicin A, Anti-Bacterial Agents, chemistry.chemical_compound, Chemistry, Aminoglycosides, Biochemistry, chemistry, Drug Discovery, Fermentation, Micromonospora
Abstract

The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacylfortimicins E was accomplished. The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several Gram-negative and Gram-positive microorganisms.

Published
1979

61. C(8) Epimeric 8-hydroxy-erythromycins-B

Author

Paul Kurath, Jerry R. Martin, Jack Tadanier, Alma W. Goldstein, Richard S. Egan, and Daniel A. Dunnigan

Subjects
Magnetic Resonance Spectroscopy, Organic Chemistry, Molecular Conformation, Stereoisomerism, Biochemistry, Catalysis, Erythromycin, Inorganic Chemistry, Lactones, Acetals, Ethers, Cyclic, Alcohols, Drug Discovery, Physical and Theoretical Chemistry
Published
1973

68. The conformation of erythromycin aglycones

Author

Thomas J. Perun and Richard S. Egan

Subjects
chemistry.chemical_classification, Magnetic Resonance Spectroscopy, Chemical Phenomena, Chemistry, Organic Chemistry, Erythromycin, Glycoside, Nuclear magnetic resonance spectroscopy, Biochemistry, Drug Discovery, medicine, Organic chemistry, Glycosides, medicine.drug
Published
1969

71. Structure of chelocardin, a novel tetracycline antibiotic

Author

Jay R. Schenck, William W. Andres, Richard S. Egan, Janardan V. Juvarkar, William Rosenbrook, and Lester A. Mitscher

Subjects
Magnetic Resonance Spectroscopy, Chemical Phenomena, medicine.drug_class, Chemistry, Spectrum Analysis, Circular Dichroism, Tetracycline antibiotics, General Chemistry, Naphthalenes, Tetracycline, Biochemistry, Catalysis, Microbiology, Anti-Bacterial Agents, Methylamines, Colloid and Surface Chemistry, medicine, Chelocardin
Published
1970

72. Nuclear magnetic resonance study of the conformation of 2-substituted 1,3-dithiolane-1,1,3,3-tetraoxides

Author

Louis C. Martinelli, Larry A. Sternson, and Richard S. Egan

Subjects
Relaxometry, Electron nuclear double resonance, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, Solid-state nuclear magnetic resonance, Organic Chemistry, Spin echo, Ferromagnetic resonance, Two-dimensional nuclear magnetic resonance spectroscopy, Nuclear magnetic resonance decoupling, Dithiolane
Abstract

Zur NMR-spektroskopischen Untersuchung der Konformationen werden aus den 1,3- Dithiolanen (I) mit m-Chlorperbenzoesaure die Tetroxide (II) hergestellt.

Published
1974
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73. Antibiotic glycosides. VII. 10,11-Dihydropicromycin: Another metabolite of MStreptomyces venezuelae

Author

James B. McAlpine, John Corcoran, Jaroslav Majer, and Richard S. Egan

Subjects
Pharmacology, Streptomyces venezuelae, chemistry.chemical_classification, Chemical Phenomena, biology, medicine.drug_class, Metabolite, Antibiotics, Glycoside, Drug Resistance, Microbial, biology.organism_classification, Streptomyces, Anti-Bacterial Agents, Microbiology, Chemistry, chemistry.chemical_compound, chemistry, Isotope Labeling, Drug Discovery, medicine, Dihydropicromycin, Glycosides, Bacillus subtilis
Published
1976
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75. Structure of lankamycin

Author

Richard S. Egan and Jerry R. Martin

Subjects
Magnetic Resonance Spectroscopy, Colloid and Surface Chemistry, Stereochemistry, Chemistry, Lankamycin, General Chemistry, Biochemistry, Streptomyces, Catalysis, Anti-Bacterial Agents
Published
1970
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77. Solution conformation of (+)-tubocurarine chloride

Author

Ruth S. Stanaszek, David E. Williamson, and Richard S. Egan

Subjects
Crystallography, Chemistry, Inorganic chemistry, medicine, Rotation, Chloride, Tubocurarine chloride, medicine.drug
Abstract

N.m.r. studies have determined the solution conformation of (+)-tubocurarine chloride (2). The conformation is not rigid and variable temperature n.m.r. spectra have disclosed hindered phenyl rotation.

Published
1973
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